Dr. Alastair Fleming
Associate Professor, Microbiology
Publications and Further Research Outputs
Peer-Reviewed Publications
Patrícia Alves de Castro , Camila Figueiredo Pinzan , Thaila Fernanda Dos Reis , Clara Valero , Norman Van Rhijn , Carla Menegatti , Ivan Lucas de Freitas Migliorini , Michael Bromley , Alastair B Fleming , Aimee M Traynor , Özlem Sarikaya-Bayram , Özgür Bayram , Iran Malavazi , Frank Ebel , Júlio César Jerônimo Barbosa , Taícia Fill , Monica Tallarico Pupo , Gustavo H Goldman, Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection, Nature Communications, 15, (1), 2024, p1 - 18
Lee B, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB., The influence of flocculation upon global gene transcription in a yeast CYC8 mutant, Microbial Genomics, 10, (1), 2024, p1 - 17
Brenda Lee, Distinct phenotypes and transcriptomes of tup1 and cyc8 mutants suggest novel roles for TUP1 and CYC8 in Saccharomyces cerevisiae, Trinity College Dublin, 2023
Karahoda B, Pfannenstiel BT, Sarikaya-Bayram Ö, Dong Z, Ho Wong K, Fleming AB, Keller NP, Bayram Ö., The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus., Fungal genetics and biology : FG & B, 169, 2023, p103836
Lee B, Church M, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB., Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex., PLoS genetics, 19, (8), 2023, pe1010876
Karahoda, B. and Pardeshi, L. and Ulas, M. and Dong, Z. and Shirgaonkar, N. and Guo, S. and Wang, F. and Tan, K. and Sarikaya-Bayram, Ã-. and Bauer, I. and Dowling, P. and Fleming, A.B. and Pfannenstiel, B.T. and Luciano-Rosario, D. and Berger, H. and Graessle, S. and Alhussain, M.M. and Strauss, J. and Keller, N.P. and Wong, K.H. and Bayram, Ã-., The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis, Nucleic acids research, 50, (17), 2022, p9797-9813
Pranay Agarwal, Investigating Tup1-Cyc8 complex function in Saccharomyces cerevisiae following the confirmation and characterization of a TUP1 conditional mutant, Trinity College Dublin, 2022
Nicole Byrne, Investigating the interplay between the Tup1-Cyc8 and Swi-Snf chromatin remodelling complexes in Saccharomyces cerevisiae, University of Dublin, Trinity College Dublin, 2021
Silva LP, Frawley D, Assis LJ, Tierney C, Fleming AB, Bayram O, Goldman GH, Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources., mSphere, 5, (5), 2020, p1-14
Frawley D, Greco C, Oakley B, Alhussain MM, Fleming AB, Keller NP, Bayram Ö.Cell , The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus., Cellular Microbiology, 22, (6), 2020, p1-14
Mohamed Alhussain, Investigating chromatin remodelling by the Tup1-Cyc8 and Swi-Snf complexes in Saccharomyces cerevisiae, University of Dublin, Trinity College Dublin, 2020
Frawley D, Stroe MC, Oakley BR, Heinekamp T, Straßburger M, Fleming AB, Brakhage AA, Bayram Ö, The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus., Frontiers in Microbiology, 11, (811), 2020, p10.3389/fmicb.2020.00811
Kröger C, Schauer K, Clerkin S, Maertlbauer E and Fleming AB, Draft Genome Sequence and Annotation of Acinetobacter junii MHI21018, Isolated from Bovine Colostrum, Microbiology Resource Announcements, 2019
Church MC, Fleming AB, A role for histone acetylation in regulating transcription elongation., Transcription, 2018
Young, Conor P and Hillyer, Cory and Hokamp, Karsten and Fitzpatrick, Darren J and Konstantinov, Nikifor K and Welty, Jacqueline S and Ness, Scott A and Werner-Washburne, Margaret and Fleming, Alastair B and Osley, Mary Ann, Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast, BMC genomics, 18, (1), 2017, p107
Church M, Smith KC, Alhussain MM, Pennings S, Fleming AB., Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene, Nucleic Acids Research, 45, (8), 2017, p4413 - 4430
Conor Young, Investigating transcription and the histone methylation landscape in quiescent cells of Saccharomyces cerevisiae, Trinity College Dublin, 2015
Michael Church, Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Trinity College Dublin, 2015
Haran J, Boyle H, Hokamp K, Yeomans T, Liu Z, Church M, Fleming AB, Anderson MZ, Berman J, Myers LC, Sullivan DJ, Moran GP, Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits., PLoS genetics, 10, (10), 2014, pe1004658
Fleming, AB, Beggs S, Church M, Tsukihashi Y, Pennings S., The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene., Biochim Biophys Acta - Gene regulatory Mechanisms, 1839, (11), 2014, p1242 - 1255
Shieh, G.S., Pan, C.-H., Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., (...), Kao, C.-F., H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast, BMC Genomics, 12, 2011, part. no. 627
Barski, A. and Chepelev, I. and Liko, D. and Cuddapah, S. and Fleming, A.B. and Birch, J. and Cui, K. and White, R.J. and Zhao, K., Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes, Nature Structural and Molecular Biology, 17, (5), 2010, p629-634
Artem Barski, Iouri Chepelev, Joanna Birch, Suresh Cuddapah, Alastair B. Fleming, Dritan Liko, Kairong Cui, Robert J. White and Keji Zhao, Pol II and its associated epigenetic marks co-localize throughout the genome with pol III-transcribed non-coding RNA genes, Nature Molecular & Structural Biology, 17, (5), 2010, p629-634
Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA., H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, Molecular Cell, 31, (1), 2008, p57 - 66
Alastair Fleming and Sari Pennings, Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene., Nucleic Acids Research, 35, (16), 2007, p5520 - 5531
Osley MA, Fleming AB, Kao CF., Histone ubiquitylation and the regulation of transcription., Results and Problems in Cell Differentiation, 41, (2006), 2007, p47 - 75
Tsukuda T, Fleming AB, Nickoloff JA, Osley MA., Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae., Nature, 438, (7066), 2005, p379 - 383
Fleming A, Osley MA., Silence of the rings., Cell, 119, (4), 2004, p449 - 451
Fleming, A.B. and Pennings, S. , Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation, EMBO Journal, 20, (18), 2001, p5219 - 5230
Fleming AB, Pennings S., Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation., Yeast, XXth YGM Conference, Prague, Czech Republic, August 26-31, 18, 2001, pp95 - 96
Tangney, M., Fleming, A.B., Jorgensen, and Priest, F.G, You have full text access to this OnlineOpen articleRegulation of maltose metabolism in stationary phase cultures of an asporogenous mutant of Bacillus licheniformis , Journal of Applied Microbiology, 84, (2), 1998, p201 - 206
Fleming AB, Tangney M, Jørgensen PL, Diderichsen B, Priest FG., Extracellular enzyme synthesis in a sporulation-deficient strain of Bacillus licheniformis., Applied and environmental microbiology, 61, (11), 1995, p3775 - 3780
Non-Peer-Reviewed Publications
Alastair Fleming, The epigenetic landscape of quiescent yeast cells. , University of Maynooth, 13 Feb, 2015
Alastair Fleming, Ursula Bond, Gary Moran and Derek Sullivan, Irish Fungal Society Meeting, 11-12 June , 2015, Trinity College Dublin
Alastair Fleming, The epigenetic landscape of quiscent yeast cells, Irish Fungal Society Meeting, 11-12 June, 2015
Suzanne Beggs and Alastair Fleming, Investigating nucleosome dynamics during transcription elongation in Saccharomyces cerevisiae, EMBO Gene Transcription in Yeast, Sant Feliu de Guíxols, Spain, 14-19 June, 2014
Michael Church and Alastair Fleming, Investigating FLO1 gene regulation by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae, Irish Fungal Society Meeting, NUI Galway, 19-20 June, 2014, Irish Fungal Society
Alastair Fleming, Conor Young, Cory Hillyer and Mary Ann Osley, The histone modification landscape of quiescent yeast cells formed during chronological aging, Keystone Conference in Cancer Epigenetics, Santa Fe, New Mexico, USA, 20-24 March, 2013
Alastair Fleming, Chromatin remodelling during yeast stationary phase, University of Cork, 2012
Cory Hillyer, Nikifor Konstantinov, Alastair B. Fleming, and Mary Ann Osley , Histone modification patterns during development of budding yeast stationary phase, Signalling to Chromatin, Cambridge, UK, 7th - 10th Sept 2010, edited by Wellcome Trust , 2010
Alastair Fleming, Interplay between H2B ubiquitylation and histone chaperones during transcription, Scottish Chromatin Group, MRC, Edinburgh, UK, 24 th October, 2007, Scottish Chromatin Group
Fleming, A.B., Kao, C.K., Hillier, C., Pickaart, M. and Osley, M. A, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, FASEB, Chromatin and transcription, Snowmass, Colorado, USA, July 7th - 12th, 2007
Alastair Fleming, Different roles for H2B ubiquitylation and H3 methylation during gene transcription in yeast, Edinburgh Systems Biology Group Meeting, University of Edinburgh, 1 November, 2007
Alastair Fleming, H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation, CMBS seminar series, University of St. Andrews, 10th September, 2007
Research Expertise
Recognition
Memberships
Microbiology Society