Publications and Further Research Outputs
Peer-Reviewed Publications
Jerome Fakhry and David H. Grayson, One-pot synthesis of α-phenylsulfinyl ketones by reaction of phenyl benzenethiosulfinate with enolate anions, and synthesis of sulfoxides and sulfides by its reaction with Grignard reagents., Tetrahedron, 74, (5), 2018, p556 - 563
Synthesis of guanidines and some of their biological applications in, editor(s)Philipp Selig , Topics in Heterocyclic Chemistry: Guanidines as Reagents and Catalysts, Switzerland, Springer, 2017, pp1 - 52, [J. W. Shaw, D. H. Grayson, I. Rozas]
Shaw J.W, Barbance L, Grayson D.H, Rozas I, Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines, Tetrahedron Letters, 56, (35), 2015, p4990 - 4992
Gallagher E.T, Grayson D.H, Reactions of aldehydes with organozinc reagents derived from (E)-3-bromo- And ( E)-3-iodo-1-phenylsulfonylprop-1-ene, Arkivoc, 2014, (5), 2014, p420 - 429
J. Shaw, I. Rozas, D.H. Grayson, Synthesis of cyclic guanidines: 2-arylamino-1,4,5,6-tetrahydropyrimidines, Arkivoc, ii, 2014, p161-174
Eichler M.C, Grayson D.H, Huddleston J, O'Neill J.P, Stobbe-like condensation reactions of the anion of diethyl (2-carboethoxy)benzylphosphonate with some aromatic and heterocyclic aldehydes, 2014, -
Lewis F.W, Grayson D.H, An improved synthesis of 10-isobornylsultone, Tetrahedron Asymmetry, 25, (15), 2014, p1150 - 1152
Eichler M.C, Grayson D.H, Ozonolysis of some 8-alkoxyquinolines, and synthesis of a precursor to the non-sedating antihistamine Claritin, Arkivoc, 2014, (6), 2014, p38 - 53
Shaw, J.W. Grayson, D.H. Rozas, I., Cleavage of 2-(Arylamino)-4,6-dimethoxypyrimidines to yield arylguanidines, European Journal of Organic Chemistry, 2014, (17), 2014, p3565 - 3569
Frank W. Lewis and David H. Grayson, The diastereoselective Meth-Cohn epoxidation of camphor-derived vinyl sulfones, Tetrahedron: Asymmetry, 23, (9), 2012, p643 - 649
Frank W. Lewis, Thomas C. McCabe, David H. Grayson, Preliminary investigations on novel camphor-derived chiral sulfones: completely stereoselective formation of tricyclic β-hydroxysulfones from 8- and 10- functionalized camphor derivatives, Tetrahedron, 67, (39), 2011, p7517-7528
A.J. Shaw, T.G. Harrison, S.J. Croker, M. Medley, L. Sellou, K.L. Shallcross, S.J Williams, D.H. Grayson, D.E. Shallcross, University-School Partnerships: on the impact on students of Summer Schools (for school students aged 17-18) run by Bristol ChemLabS, Acta Didactica Napocensia, 3, (4), 2010, p35-48
David P. Power, Olivier Lozach, Laurent Meijer, David H. Grayson, Stephen J. Connon, Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones, Bioorganic & Medicinal Chemistry Letters, 20, (16), 2010, 4940-4944
F. W. Lewis, G. Egron and D. H. Grayson, Unexpected formaiton of 10-iodo- and 10-chlorocamphor under halosulfonylation conditions, and convenient routes to 10-chloro- and 10-bromocamphor, Tetrahedron: Asymmetry, (20), 2009, p1531 - 1535
F. W. Lewis, M. C. Eichler and D. H. Grayson, Synthesis of b-amino alcohols via the reduction of lactamides derived from ethyl (2S)-lactate with borane-methyl sulfide, Synlett, (12), 2009, p1923 - 1928
R. D. Gunning, M. Venkatesan, D. H. Grayson and J. M. D. Coey, Magnetic propertiers of CNX whiskers, Carbon, 44, 2006, p3213 - 3217
S. S. Kelly, P. M. Glynn, S. J. Madden and D. H. Grayson, Impurities in a morphine sulfate drug product identified as 5-(hydroxymethyl)-2-furfural, 10-hydroxymorphine and 10-oxomorphine, J. Pharm. Sci., 92, 2003, p451 - 459
D. H. Grayson and S. H. O?Donnell, Addition of nucleophiles to (E)-3-phenylsulfonylprop-2-enenitrile: a route to b-substituted a,b-unsaturated nitriles and to acetals of cyanoacetaldehyde, ARKIVOC, 2003, p4 - 14
D. H. Grayson, U. McCarthy and E. D. Roycroft, Intramolecular acylative ring-switching reactions of 3-(tetrahydro-2?-furyl)propanoic acid derivatives to give butanolides: mechanism and scope, Org. Biomol. Chem., 1, 2003, p1930 - 1937
D. Cunningham, D. H. Grayson, P. McArdle and J. Walsh, The bromination of (?)-camphorquinone, Tetrahedron: Asymmetry, 14, 2003, p1197 - 1200
E. T. Gallagher and D. H. Grayson, Reactions of lithiated (E)-3-halo-1-phenylsulfonylprop-1-enes and of (Z)-1-halo-3-phenylsulfonylprop-1-enes with aldehydes, Org. Biomol. Chem., 1, 2003, p1374 - 1381
W. Cocker, D. H. Grayson and P. V. R. Shannon, Hydrocyanation of some a,b-unsaturated ketones, and the synthesis of some unusual isoxazoles., J. Chem. Soc., Perkin Trans. 1, 1995, p1153 - 1162
D. H. Grayson and E. D. Roycroft, Synthesis of butanolides via intramolecular acylative ring-opening reactions of 3-(tetrahydro-2-furyl)propanoic acid derivatives, J. Chem. Soc., Chem. Commun., 1992, p1296-
M. S. Carson and D. H. Grayson, Monoterpenoids, Nat. Prod. Rep., 3, 1986, p251-
P. McWilliam, Y. McKeown, M. Newell, S.Thompson, P. Lohman, B. Enger-Valk, P. Pouwels and D. H. Grayson, Molecular interaction of the aromatic carcinogen 2-nitrosofluorene with DNA., Proc. EC Contractor?s Meeting, Athens, 1985., 1985
D. H. Grayson, J. M. Kelly, E. M. Moran, W. A. Nevin, C. M. O?Connell, M. M. O?Kane, D. C. Pepper, J. G. Vos and A. Yague-Ferrer, Polymer-bound Porphyrins and Polymer-bound Coordination Compounds as Converters of Solar Energy into Chemical Fuels., Second EC Solar Energy R and D Programme, Project D, Final Report, 1984., 1984
D. H. Grayson, Regiospecific formation of a p-menthenone from (+)-a-3,4-epoxycarane., Proc. Roy. Irish Acad., 83B, 1983, p85-
W. Cocker and D. H. Grayson, The Chemistry of Terpenes. Part 23. Reaction of (+)-carane-3b,4a-diol with sulphuric acid., J. Chem. Soc., Perkin Trans. 1, 1978, p155-
W. Cocker, D. H. Grayson and N. W. A. Geraghty, The Chemistry of Terpenes. Part 25. A synthesis of car-2 - car-3- and car-3(10)-ene., J. Chem. Soc., Perkin Trans. 1, 1978, p1370-
P. H. Boyle, W. Cocker, D. H. Grayson and P. V. R. Shannon, The Chemistry of Terpenes. Part XIV. Syntheses of (±)- and (+)-fenchone, and of (+)-cis-2,2,5-trimethyl-3-vinylcyclopentanone, a photoisomer of (-)-cis-caran-4-one, J. Chem. Soc., C, 1971, p2136-
W. Cocker and D. H. Grayson, A convenient preparation of (?)-b-3,4-epoxycarane., Tetrahedron Lett., 1969, p4451-
Research Expertise
Description
Development of new methods for organic synthesis; synthesis of complex natural products, especially medium-ring and macrocyclic lactones; cycloaddition chemistry of vinylic sulfones; chemistry of sulfonyl-stabilised anions; chiral auxiliaries and reagents derived from monoterpenoids; heterocyclic chemistry, especially the chemistry of 4-dimethylaminopyridine N-oxide and some homochiral derivatives.Projects
- Title
- · Synthesis of macrocyclic lactones (Lawrence Cook)
Recognition
Memberships
CChem FRSC