Professor Feras Abu Saadeh
Clinical Associate Professor, Obstetrics
Biography
Feras obtained his medical degree (MB ChB) in Sebha Medical University in 2000. He then completed 5 years of post graduate training in obstetrics and gynaecology in Maqased Hospital, Jerusalem, before arriving in Ireland in 2005.
Since 2006 he is a member of the Royal College of Obstetrician and Gynaecologist (UK), Royal College of Physician (Ireland) and member of the British Society of Colposcopy and Cervical Pathology (BSCCP). In 2008, he was appointed as lecturer at Cork University Maternity Hospital where he played a significant role in undergraduate teaching and was involved in the establishment and first year of operation of the first Robotic theatre in the country. Feras joined St. James's hospital in 2009 and was instrumental in transforming the gynaecology services from open traditional surgery to minimal access surgery.
His research lab located in the Institute of Molecular Medicine/ Trinity College focus on biomarker for ovarian cancer and cancer associated thrombosis. His research was published in international peer reviewed journals. Feras has an MD from Trinity College Dublin and he is an RCOG accredited subspecialist in Gynaecology Oncology. Since 2013, he is working as a Consultant Gynaecological Oncologist at St. James's hospital, Dublin and is a senior clinical lecturer for Trinity College Dublin.
Publications and Further Research Outputs
Peer-Reviewed Publications
Kelly TE, Spillane CL, Ward MP, Hokamp K, Huang Y, Tewari P, Martin CM, Norris LA, Mohamed BM, Bates M, Brooks R, Selemidis S, Brooks DA, Kamran W, Saadeh FA, O'Toole SA, O'Leary JJ., Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy., Frontiers in cell and developmental biology, 11, 2023, p1150991
Mohamed BM, Ward MP, Bates M, Spillane CD, Kelly T, Martin C, Gallagher M, Heffernan S, Norris L, Kennedy J, Saadeh FA, Gleeson N, Brooks DA, Brooks RD, Selemidis S, O'Toole S, O'Leary JJ., Ex vivo expansion of circulating tumour cells (CTCs)., Scientific reports, 13, (1), 2023, p3704 - 3704
Ffrench B, Kashdan E, Huang Y, Spillane CD, Cocchiglia S, Charmsaz S, Varešlija D, O'Brien C, Scholz D, Martin C, Gallagher M, Brooks DA, Brooks RD, Selemidis S, Gleeson N, AbuSaadeh F, O'Riain C, Kamran W, Flavin R, Young L, O'Toole SA, O'Leary JJ., CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity., Heliyon, 9, (1), 2023, pe13044
Lucy A. Norris, Feras Abu Saadeh, "Risk of venous thromboembolism and bleeding after major surgery for ovarian cancer: standard in-hospital versus extended duration of thromboprophylaxis": Comment, Journal of Thrombosis and Haemostasis, 21, (6), 2023, p1681--1683
Wiktoria Irena Batog, Ciarán Ó Riain, Feras Abu Saadeh, The dilemma of managing thyroid gland after incidental diagnosis of malignant struma Ovarii. Is radical thyroidectomy and radioactive iodine Necessary? A case report and literature review, Gynecologic Oncology Reports, 47, 2023, p101189
Ward MP, O'Toole SA, Abu Saadeh F, Marchocki Z, Ibrahim EM, Martin F, Gleeon N, O'leary JJ, Norris LA, Mechanisms of cancer associated thrombosis in gynaecological cancer patients- tumour or treatment effect?, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, London, July 2022, 6, (Supplement 2), Wiley, 2022, ppPB0752 - PB0752
Batog, WI, Maguire P, O'Toole SA, Norris L, Abu Saadeh F, Identification of groin node metastasis in squamous vulval cancer using pre-operative [18F] FDG-PET/CT. Can unnecessary lymphadectomy be prevented?, International Journal of Gynaecological Cancer, European Society for Gynaecological Oncology, Berlin, October 2022, 32, (Supplement 2), 2022, pp1590 - 1590
Vergote I, Gonzalez-Martin A, Lorusso D, Gourley C, Mirza MR, Kurtz JE, Okamoto A, Moore K, Kridelka F, McNeish I, Reuss A, Votan B, du Bois A, Mahner S, Ray-Coquard I, Kohn EC, Berek JS, Tan DSP, Colombo N, Zang R, Concin N, O'Donnell D, Rauh-Hain A, Herrington CS, Marth C, Poveda A, Fujiwara K, Stuart GCE, Oza AM, Bookman MA, participants of the 6th Gynecologic Cancer InterGroup (GCIG) Ovarian Cancer Consensus Conference on Clinical Research., Clinical research in ovarian cancer: consensus recommendations from the Gynecologic Cancer InterGroup., The Lancet. Oncology, 23, (8), 2022, pe374-e384
Ward MP, Lochrin SE, Ovarere C, O'Gorman C, Kane LE, Mohamed BM, Bates M, Kelly TE, O'Connor R, Kennedy J, Cadoo K, Kamran W, Beirne J, Abu Saadeh F, Martin CM, Norris LA, O'Toole SA, O'leary JJ, Platelets and immune call cloaking of circulating tumour cells in breast and ovarian cancer, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, London, July 2022, 6, ((supplement 2)), Wiley, 2022, ppPB0931 - PB0931
Elzahra Ibrahim, Lucy Norris, Feras Abu Saadeh, Does the use of long-term Aspirin reduce risk of post operative VTE in Gynaecological cancer patients, International Journal of Gynecologic Cancer, 23rd ESGO, Berlin, Oct 2022, 32, 2022
Farrell RA, Maguire PJ, Ovaere C, Khamayseh I, Saadeh FA., Loop colostomy formation with a skin bridge technique in a gynecological oncology center., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2022, pijgc-2022-003507
Safavi D, Subramaniam VS, Obeidi N, Egan M, Abu Saadeh F., Post-operative ureteral injury after cytoreductive surgery for ovarian cancer managed by primary repair through minimally invasive approach., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2022, pijgc-2022-003963
Wiktoria Irena Batog, 2 Patrick J Maguire, 1 Sharon O Toole, 1 Lucy Norris, 1,2Feras Abu Saadeh. 1, IDENTIFICATION OF GROIN NODE METASTASIS IN SQUAMOUS VULVAL CANCER USING PREOPERATIVE [18F] FDGPET/CT. CAN UNNECESSARY LYMPHADENECTOMY BE PREVENTED?, International Journal of Gynecologic Cancer, 23rd ESGO, Berlin, 32, 2022
Farrell RA, Maguire PJ, Freyne A, Siddiki S, Saadeh FA., Use of an artificial mammary implant in total pelvic exenteration., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2021
Floyd R, Hunter S, Abu Saadeh F, McDonnell C, McCormick P., Pelvic actinomycosis., QJM : monthly journal of the Association of Physicians, 114, (8), 2021, p587-588
Ward, Mark P., Saadeh, Feras Abu, O'Toole, Sharon A., O'Leary, John J., Gleeson, Noreen, Norris, Lucy A., Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway, Thrombosis Research, 200, 2021, p91 - 98
O'Toole SA, Huang Y, Norris L, Power Foley M, Shireen R, McDonald S, Kamran W, Ibrahim N, Ward M, Thompson C, Murphy C, D'Arcy T, Farah N, Heron E, O'Leary JJ, Abu Saadeh F, Gleeson N., HE4 and CA125 as preoperative risk stratifiers for lymph node metastasis in endometrioid carcinoma of the endometrium: A retrospective study in a cohort with histological proof of lymph node status., Gynecologic oncology, 2021
Kate McKendry Stephen Duff Yanmei Huang Mostafa Redha Áine Scanlon Feras Abu Saadeh Noreen Gleeson John O'Leary Lucy Norris Sharon O'Toole, The value of human epididymis 4, D‐dimer, and fibrinogen compared with CA 125 alone in triaging women presenting with pelvic masses: a retrospective cohort study, Acta Obstetricia et Gynecologica Scandinavica, 2021
McKendry, Kate, Duff, Stephen, Huang, Yanmei, Redha, Mostafa, Scanlon, Áine, Abu Saadeh, Feras, Gleeson, Noreen, O"Leary, John, Norris, Lucy, O"Toole, Sharon, The value of HE4, D"dimer, and fibrinogen compared to CA125 alone in triaging women presenting with pelvic masses: a retrospective cohort study, Acta Obstetricia et Gynecologica Scandinavica, 2021
Abu Saadeh F, Marchocki Z, O'Toole SA, Ibrahim N, Gleeson N, Norris LA., Extended thromboprophylaxis post gynaecological cancer surgery; the effect of weight adjusted and fixed dose LMWH (Tinzaparin)., Thrombosis Research, 207, 2021, p25 - 32
Norris LA, Ward MP, O'Toole SA, Marchocki Z, Ibrahim N, Khashan AS, Abu Saadeh F, Gleeson N., A risk score for prediction of venous thromboembolism in gynecologic cancer: The Thrombogyn score., Res Pract Thromb Haemost, 4, (5), 2020, p848-859
Daly N, DeMaio A, Daly R, Saadeh FA, Laparoscopic Boari flap formation in advanced ovarian carcinoma., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2020
Marchocki, Z., Norris, L.A., Abu Saadeh, F., Gleeson, N., Recurrence of venous thromboembolism in patients with gynaecological malignancies: Incidence, risk factors, and impact on survival, European Journal of Gynaecological Oncology, 40, (3), 2019, p413-419
Marchocki Z, Norris L, O'Toole S, Gleeson N, Abu Saadeh F, Patients' experience and compliance with extended low molecular weight heparin prophylaxis post-surgery for gynaecological cancer. A prospective observational study, International Journal of Gynaecological Cancer. , 2019
Sarah Petch 1 , Aleksandra Sobota 2 , Feras Abu Saadeh , Sister Mary Joseph nodule: an unusual site for endometrioid cancer metastasis, BMJ Case Reports, 2019
Z. Marchocki, L.N. Norris, S.A. O'Toole, N. Gleeson, F. Abu Saadeh S235, Patients experience and compliance with extended LMWH prophylaxis post-surgery for gynaecological cancer, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2018, 164, (Supplement 1), Elsevier, 2018, ppS235 - S235
Ward MP, Abu Saadeh, F, O'Toole S, Marchocki Z, Gleeson N, Norris LA, Optimisation of Thrombin Generation as a Predictive Biomarker for Venous Thromboembolism in Gynaecological Malignancies, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, Dublin, July 2018, 2, (Supplement 1), Wiley, 2018, ppPB518 - PB518
Z. Marchocki, N. Gleeson, F. Abu Saadeh, M.P. Ward, S.A. O'Toole, L.A. Norris, Fibrinogen, D-Dimers and thrombin generation assays as predictors of the risk of recurrent VTE in patients with gynaecological malignancies, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2018, 164, (Supplement 1), 2018, pp200 - 200
LA Norris, F Abu Saadeh, M Ward, SA O'Toole, Z Marchocki, N. Ibrahim, N Gleeson, Development and validation of a risk model for prediction of venous thromboembolism in gynaecological cancer patients, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2018, 164, (Supplement 1), Elsevier, 2018, ppS183 - S184
Saadeh Feras Abu, Riain Ciaran O, Mc Cormack Ciara, Gleeson Noreen, Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? , Irish Journal of Medical Science , 2018
Cathy Spillane, Brendan Ffrench, Anthony Cooney, Carmel Ruttle, Anna Bogdanska, Noreen Gleeson, Feras Abu Saadeh, Waseem Kamran, Ciaran O'Riain, Ricahrd Flavin, Michael Gallagher, Cara M Martin, Orla Sheils, Sharon O'Toole, John J O'Leary, A Digital Pathology Method to Identify All Forms of CTC, LABORATORY INVESTIGATION, USCAP, 97, Nature Publishing Group, 2017, pp463 - 463
Marchocki Z, Riain CO', Thompson C, Abu Saadeh F, CANCER-RELATED SEVERE HYPERCALCEMIA IN OVARIAN ADENOSARCOMA-A CASE REPORT , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2017, pp1589 - 1589
Marchocki Z, Abu Saadeh F, MESONEPHRIC LIKE ENDOMETRIOID UTERINE CARCINOMA-A CASE REPORT. , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2017, pp1151 - 1151
C. Spourquet1, M.P. Ward1, F.A. Saadeh2, J.J. O'Leary3, N. Gleeson1,2, S.A. O'Toole1,3, L.A. Norris1, Expression of Coagulation Proteases from the Activated Protein C Pathway in Ovarian Tumours, ISTH, Berlin, 2017
Marchocki Z, McDonnell S, Thompson C, Kamran W, Abu Saadeh F, SQUAMOUS CELL CARCINOMA ARISING IN A MATURE CYSTIC TERATOMA-TWO CASE REPORTS , 19th International Meeting of the European Society of Gynaecological Oncology, Nov 2017, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2017, pp1588 - 1588
Katie Field, Lucy Norris, Feras Abu Saadeh, Mark Ward,Hugh O'Connor & Noreen Gleeson, miRNA, a possible solution to the search in Biomarkers for Endometriosis?, 13th World congress on Endometriosis , Vancouver, 2017
Dr. Sarah Petch, Dr. Aleksandra Sobota, Dr. Claire Thompson, Dr. Ciaran O'riain, Dr. Dr Feras Abu Saadah, Sister Mary Joseph Nodule- An Unusual Site For Endometrioid Cancer Metastasis. A Case Report., Fourth Irish Congress of Obstetrics, Gynaecology & Perinatal Medicine, Ireland, 2017
Katie Field, Lucy Norris, Feras Abu Saadeh, Mark Ward,Hugh O'Connor & Noreen Gleeson, The role of IL-6, MMP-2 and MMP-9 as Biomarkers for Endometriosis, 13th World congress on Endometriosis , Vancouver, 2017, 2017
Thompson C, O'Riain C, Abu Saadeh F, A CASE OF MALIGNANT STRUMA OVARII CONFINED TO THE OVARY WITH SYNCHRONOUS PAPILLARY THYROID CARCINOMA DETECTED FOLLOWING THYROIDECTOMY , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2017, pp1691 - 1691
M.P. Ward1, F.A. Saadeh2, J.J. O'Leary3, N. Gleeson1,4, S.A. O'Toole1,3, L.A. Norris1, The Effect of Neoadjuvant Chemotherapy on the Activated Protein C (aPC) Pathway in High Grade Serous Ovarian Cancer Patients, ISTH , Berlin, 2017, 2017
Marchocki Z, O'Riain C, Kamran W, Abu Saadeh F, HIGH GRADE ENDOMETRIAL STROMAL SARCOMA ASSOCIATED WITH YWHAE-FAM22 REARRANGEMENT-TWO CASE REPORTS. , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2017, pp1150 - 1150
Marchocki Z, Saadeh F Abu, Gleeson N, Norris L, P-077: Risk of recurrence of venous thromboembolism in patients with gynaecological cancer , The 6th International Symposium on Women's Health Issues in Thrombosis and Haemostasis (WITH), Spain , 151 , 2017, ppS133 -
Marchocki Z, Abu Saadeh F, Gleeson N, Norris L, Risk of recurrence of venous thromboembolism in patients with gynaecological cancer, Thrombosis Research, Womens Issues in Thrombosis and Haemostasis, Barcelona, March 2017, 151, (Supplement 1), 2017, ppS133 - S133
Thompson C, Abu Saadeh F, AN ALTERNATIVE ROLE FOR A BREAST IMPLANT FOLLOWING TOTAL PELVIC EXENTERATION , 19th International Meeting of the European Society of Gynaecological Oncology, Vienna, Austria , 2017, 27 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2017, pp1387 - 1387
Abu Saadeh, F, Langhe R, Galvin DM, O Toole SA, O'Donnell DM, Gleeson N, Norris LA, Procoagulant activity in gynaecological cancer patients; the effect of surgery and chemotherapy. , Thrombosis Research, 139, 2016, p135 - 141
Martin F, Long JC, O'Toole SA, O'Leary JJ, Abu Saadeh F, Gleeson N, Norris LA, Tumour expression of coagulation proteases of the aPC pathway - a role in the pathogenesis of gynaecological cancers?, Thrombosis Research, International Congress on Thrombosis and Haemostasis Issues in Cancer, Bergamo, April 2016, 140, (Supplement 1), 2016, ppS181 - S181
Field K, Ryan MJ, Saadeh FA, Kamran W, Brennan V, Gillham C, Gleeson N, Selective arterial embolisation for intractable vaginal haemorrhage in genital tract malignancies , Eur J Gynaecol Oncol , 37 , (03 ), 2016, p736 - 740
Norris LA, Martin FA, O'Toole SA, Saadeh FA, Gleeson N, PO-24 - Determinants of thrombin generation in gynaecological malignancies., 2016
Wahab NAA, Saadeh FA, Wong A, Gleeson N, Negative pressure wound treatment (NPWT) in vulva and groin wounds in gynaecologic oncology. , European journal of gynaecological oncology , 37 , (5 ), 2016, p632 - 637
Martin F, Long JC, O'Toole SA, O'Leary JJ, Abu Saadeh F, Gleeson N, Norris LA., PO-14 - Tumour expression of coagulation proteases of the aPC pathway - a role in the pathogenesis of gynaecological cancers?, Thrombosis research, 140 Suppl 1, 2016, pS181
Petch S, Norris L, O'Toole S, Gleeson N, Abu Saadeh F. , Peri operative venous thromboembolism prophylaxis in gynaecological cancer patients. A survey of current practice., Thrombosis Research, 145, 2016, p126 - 128
Spillane C, Ffrench B, Cooney A, Ruttle C, Bogdanska A, Gleeson N, Abu Saadeh F, Waseem K, O'Riain C, Flavin R, A NOVEL DIGITIAL PATHOLOGY APPROACH TO DEFINITIVELY IDENTIFY OVARIAN CANCER CTCS , 2016, 26 , LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, 2016, pp796 - 796
Petch S, Norris LA, O'Toole SA, Gleeson N, Saadeh FA, OC-12 - Peri operative venous thromboembolism prophylaxis in gynaecological cancer patients. A survey of current practice., 2016
Abu Saadeh F , Galvin D, Alsharbaty M J, Gleeson N, Paravaginal aggressive angiomyxoma , British Medical Journal Case Reports, PMID:25833906, 2015
Martin F, O'toole SA, Long JC, O'leary JJ, Gleeson N, Saadeh FA, Norris LA, expression of coagulation proteases from the Apc pathway in tumours from gynaecological cancer patients with and without venous thrombosis: Or360 , 13 , 2015, pp233 - 234
Saadeh Feras Abu, Galvin Daniel, Alsharbaty Mohammed J, Gleeson Noreen, Case Report: Paravaginal aggressive angiomyxoma , BMJ case reports , 2015 , 2015
Saadeh FA, Cheema I, McCormick P, Gleeson N, Co-operative radical pelvic surgery: a role for the gynecologist in vaginal reconstruction using a uterine myoserosal flap in urological and anorectal cancer surgery., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2015
O'Gorman C, Burke N, Norris L, Gleeson N, Abu Saadeh F, Reducing venous thromboembolic events associated with ovarian cancer: are we winning the battle? , THROMBOSIS RESEARCH, 2015, 135 , PERGAMON-ELSEVIER SCIENCE LTD THE BOULEVARD, LANGFORD LANE, KIDLINGTONÂ â" , 2015, ppS66 - S66
Langhe R, Norris L, Saadeh FA, Blackshields G, Varley R, Harrison A, Gleeson N, Spillane C, Martin C, O'Donnell DM, D'Arcy T, O'Leary J, O'Toole S, A novel serum microRNA panel to discriminate benign from malignant ovarian disease., Cancer letters, 356, (2 Pt B), 2015, p628-36
Saadeh FA, Cheema I, McCormick P, Gleeson N, Co-Operative Radical Pelvic Surgery: A Role for the Gynecologist in Vaginal Reconstruction Using a Uterine Myoserosal Flap in Urological and Anorectal Cancer Surgery., International Journal of Gynecological Cancer, 25, (5), 2015, p931 - 936
Shireen R, Norris L, Cullen M, Zainulabdin A, Long JC, McKendry K, Martin F, Cooney A, Ripollone S, Ibrahim N, CAN HUMAN EPIDIDYMIS PROTEIN 4 (HE4) IDENTIFY OCCULT ENDOMETRIAL CARCINOMA IN WOMEN WITH ATYPICAL HYPERPLASIA? , 2015, 25 , (9 ), LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2015, pp1143 - 1143
Obeidi Nedaa, Tchrakian Nairi, Saadeh Feras Abu, Mocanu Edgar, Case Report: Suspected ovarian molar pregnancy after assisted reproductive technology conception: a diagnostic challenge , BMJ case reports , 2015 , 2015
Wahab Nor Azlia Abdul, Saadeh Feras Abu, Lavelle Mairr, Gleeson Noreen, Could sentinel node mapping of the groin cause extranodal metastasis in vulva cancer? , Gynecologic and obstetric investigation , 79 , (4 ), 2015, p280 - 284
Horan M, Demaio A, Abu Saadeh F, O'Riain C, Gleeson N, GLASSY CELL CARCINOMA OF THE CERVIX: A CASE SERIES , 2015, 25 , (9 ), LIPPINCOTT WILLIAMS & WILKINS TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIAÂ â" , 2015, pp820 - 820
Saadeh Feras Abu, Collins Vicki, Al-Saadi Maimuna, Gleeson Noreen, Case Report: An unusual relapse in acute myeloid leukaemia , BMJ CASE REPORTS , 2015 , 2015
O'toole P Sa, Rizmee S, Norris L, Cullen M, Zainulabdin A, Long JC, Martin F, Cooney A, Ripollone S, Ibrahim N, utility of Serum He4 in Diagnosis and Prognosis of Endometrial Cancer , 237 , 2015, ppS15 -
Abu Saadeh F, Collins V, Al-Saadi M, Gleeson N, An unusual relapse in acute myeloid leukaemia., BMJ case reports, 2015
Obeidi N, Tchrakian N, Abu Saadeh F, Mocanu E, Suspected ovarian molar pregnancy after assisted reproductive technology conception: a diagnostic challenge., BMJ case reports, 2015
Ibrahim. N, Norris. L, O'Toole. S, McHugh, T. Abu Saadeh. F, Gleeson. N. , Does the extended thromboprophylaxix help to reduce the incidence of venous thromboembolism in gynaecological cancer patients ?, THROMBOSIS RESEARCH, THROMBOSIS RESEARCH, 133, (S244), 2014
Kamran MW, O'Toole F, Meghen K, Wahab AN , Abu Saadeh F, Gleeson N, Whole-body [18F]fluoro-2-deoxyglucose positron emission tomography scan as combined PET-CT staging prior to planned radical vulvectomy and inguinofemoral lymphadenectomy for squamous vulval cancer: A correlation with groin node metastasis , European Journal of Gynaecological Oncology, 35, (3), 2014, p230 - 235
Abu Saadeh Feras, Wahab Nor, Gleeson N, An unusual presentation of endometriosis, British Medical Journal Case Reports , doi:10.11/bcr-2014-2, 2014
Abu Saadeh F, O'Toole S, Gleeson N, Norris L, Peak ant-Xa levels following LMWH (tinzaparin) prophylaxis in gynaecological cancer patients post surgery, Thrombosis Research, 7th Internation Conference on Thrombosis & Hemostatis Issues in Cancer, , Bergamot Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014
Wahab N Abdul, Abu Saadeh F, Lavelle M, Gleeson N, COULD SENTINEL NODE MAPPING OF GROIN LYMPH NODES CAUSE EXTRANODAL METASTASES IN VULVA CANCER? , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013
Langhe R, Norris L, Petzold M, Abu Saadeh F, Kamran W, Ibrahim N, Nassan M, Gleeson N, O'Leary JJ, O'Toole S, ROMA INDEX IMPROVES SPECIFICITY OF OVARIAN CANCER DIAGNOSIS COMPARED TO CA125 ALONE , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013
Feras Abu Saadeh, Hypercoagulability in Ovarian Cancer, TCD, 2013
Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103
Abu Saadeh F, Norris L, O'Toole S, Gleeson N, Venous thromboembolism in ovarian cancer: Incidence, risk factors and impact on survival., European Journal of Obstetrics & Gynecology and Reproductive Biology , 170, (1), 2013, p214 - 218
O'Toole F, Meghan K, Wahab A, Abu Saadeh F, Gleeson N, FDG PET-CT IN PRE-OPERATIVE ASSESSMENT OF VULVAL CARCINOMA. A SINGLE INSTITUTION'S EXPERIENCE OVER FOUR YEARS , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013
O'Malley Eimer, Saadeh Feras Abu, Nor Azlia, DIVERSE PRESENTATIONS OF TUBERCULOSIS IN OBSTETRICS AND GYNAECOLOGY , 2013, 2013, pp68 -
Meghan K, O'Toole F, Wahab A, Kamran W, Gleeson N, Abu Saadeh F, NEGATIVE PREDICTIVE VALUE OF PET-CT NODAL STATUS IN WOMEN WITH OPERABLE CERVIX CANCER , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013
Abu Saadeh F, Cheema I, Gleeson N, VAGINAL AND VESTIBULAR RECONSTRUCTION FOLLOWING RADICAL CYSTECTOMY AND URETHRECTOMY: A NEW TECHNIQUE , 2013, 23 , (8 ), LIPPINCOTT WILLIAMS & WILKINS 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA , 2013
Kamran MW, Vaughan D, Crosby D, Wahab NA, Saadeh FA, Gleeson N, Opportunistic and interventional salpingectomy in women at risk: a strategy for preventing pelvic serous cancer (PSC)., European journal of obstetrics, gynecology, and reproductive biology, 170, (1), 2013, p251-4
Abu Saadeh, Norris L, O'Toole S, Mohamed BM, Langhe R, O'Leary J, Gleeson N, Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer- relationship with venous thrombosis risk., Thrombosis Research, 132, 2013, p627 - 634
Abu Saadeh F, Norris L, O'Toole S, Langhe R, O'Leary JJ, Gleeson N., Does tissue factor and tissue factor pathway inhibitor over-expression play a role in the development of venous thromboembolism in ovarian cancer patients?, Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, ((Suppl 1)), Elsevier, 2012, pp170-
Abu Saadeh F, Norris L, O'Toole S, Langhe R, Gleeson N., Procoagulant activity in patients with gynecological malignancies and the effect of neoadjuvant chemotherapy , Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, (Suppl 1), Elsevier, 2012
O'Brien Y, O'Neill A, Abu Saadeh F, Gleeson N, PERIPARTUM CARDIOMYOPATHY , 2011, 180 , SPRINGER LONDON LTD 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND , 2011, pp132 - 132
Abu Saadeh F, Norris L, OToole S, Gleeson N, P. 86 The role of tissue factor and tissue factor pathway inhibitor in ovarian cancer , 127 , (3 ), 2011, pp1 -
O'Brien Y, Abu Saadeh F, O'Donnell D, Gleeson N, PARANEOPLASTIC SENSORY NEUROPATHY IN OVARIAN CANCER , 2011, 180 , SPRINGER LONDON LTD 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND , 2011, pp133 - 133
Field K, Saadeh F, Hewitt M, O'Reilly B, Keogh J, Improving the maternal experience: watching your baby being delivered during caesarean section , 95 , (Suppl 1 ), 2010, ppFa66 - Fa66
Nikhil Purandare, Irfan Ahmed, Seiglinde Muller, Firas Saadeh, Mother to Child Transmission of HIV; Are We Doing Enough? , Journal of South Asian Federation of Obstetrics and Gynecology , 1 , (3 ), 2009, p29 - 32
Saadeh F Abu, Hickey Mr, Should cold coagulation be the new gold standard treatment for treating Cin in young women: Fc2. 07 , 115 , 2008, pp39 -
Non-Peer-Reviewed Publications
Feras Abu Saadeh, HPV-NEGATIVE VULVAR SQUAMOUS CELL CARCINOMA IN A 21-YEAR-OLD PATIENT, by Ferreira, Dânia; Almeida, Amélia; Patrício, Vanda; Petiz, Almerinda , BMJ Case Reports, 2019
Feras Abu Saadeh, PALB2, ATM and Ovarian Cancer, Review of PALB2, ATM and Ovarian Cancer, by arbajal Mamani, Semiramis; Markham, Merry; Castagno, Jacqueline; Cardenas Goicoechea, Joel , BMJ CASE REPORTS , 2019
Feras Abu Saadeh, The bidirectional association among female hormone-related cancers: breast, ovary, and uterine corpus" for Cancer Medicine., Review of The bidirectional association among female hormone-related cancers: breast, ovary, and uterine corpus" for Cancer Medicine., by Min‐Chi Chen Kuan‐Der Lee Chang‐Hsien Lu Ting‐Yao Wang Shih‐Hao Huang Chao‐Yu Chen , cancer Medicine, 2018
Feras Abu Saadeh, Intravenous leiomyomatosis with skip metastasis, Review of Intravenous leiomyomatosis with skip metastasis, by Yunzhu Li; Qi Miao; Ninghai Cheng; Guotao Ma , World Journal of Surgical Oncology, 2018
Feras Abu Saadeh, Benign Metastasizing Leiomyoma to the lungs: a rare cause of pulmonary nodules, Review of Benign Metastasizing Leiomyoma to the lungs: a rare cause of pulmonary nodules, by Campanha, Rafaela; Malheiro, Mariana; Rosa, Rita; Barata, Catarina , BMJ CASE REPORTS , 2018
Feras Abu Saadeh, Cancer and thrombosis, Real life experience, Joint National Haematology /Obstetrics Study day, Cork, 2018
Feras Abu Saadeh, The 7th international Symposium on Women's Health Issues in Thrombosis and Haemostasis , 2017, Spain
Feras Abu Saadeh, Creation of risk index for premalignant changes of portio vaginalis uteri, Review of Creation of risk index for premalignant changes of portio vaginalis uteri, by LIDIJA DRAGOLJUB TASIC, PROF; LJILJANA GOJKO ANTIC, DR; ALEKSANDAR ILIJA JURISIC, ASS PROF; SVETLANA DIMITRIJE JANKOVIC, ASS PROF; DRAGAN ZIVORAD ANTIC, DR; AMIRA SAHIB EGIC, PROF; NATASA TRIFUN KARADZOV, ASS; NEBOJSA BORIVOJE ZECEVIC, ASS; SLADJANA JOVICA MIHAJLOVIC, DR , BMC Women's Health, 2017
Feras Abu Saadeh, An integrated approach for identifying genes associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer, Review of An integrated approach for identifying genes associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer, Ahmed Hossain, Gias Uddin Ahsan, Hayatun Nabi , Advances in Modern Oncology Research, 2017
Feras Abu Saadeh, A complete hydatidiform mole in a perimenopausal woman, Review of A complete hydatidiform mole in a perimenopausal woman, by Dockx, Sofie; Peeters, Frederik; Buytaert, Guy; Jacquemyn, Yves , BMJ CASE REPORTS , 2017
Feras Abu Saadeh, Institute Spring Meeting, Joint meeting of IOG and the Irish Society of Interventional Radiology, 2017
Feras Abu Saadeh, LMWH for women with cancer and VTE, how long and what dose, Expert meeting, Thrombosis in women and cancer , Spain , 2017
Feras Abu Saadeh, Specificity and predictive value of biomarkers for the risk of thrombosis in pancreatic adenocarcinoma, Review of Specificity and predictive value of biomarkers for the risk of thrombosis in pancreatic adenocarcinoma, by Faille, Dorothée; Bourrienne, Marie-Charlotte; de RAUCOURT, Emmanuelle; De Chaisemartin, Luc; Granger, Vanessa; Lacroix, Romaric; Panicot-Dubois, Laurence; Hammel, Pascal; Lévy, Philippe; Ruszniewski, Philippe; Ajzenberg, Nadine; Rebours, Vinciane , Thrombosis and Haemostasis,, 2017
Feras Abu Saadeh, Bowel Injury in Laparoscopic Gynaecology Cancer, GLOS course, Dublin, 2017, RCSI
Feras Abu Saadeh, Cancer, Women & Thrombosis. The Unanswered Questions, World thrombosis day, Ireland, 2016
Feras Abu Saadeh, Comparisons of the survival time of patients with ovarian cancer adopting post-operative chemotherapy by use of paclitaxel combined with carboplatin or nedaplatin, Review of Comparisons of the survival time of patients with ovarian cancer adopting post-operative chemotherapy by use of paclitaxel combined with carboplatin or nedaplatin, by Yimin Han; Hongfei Gao; Lijun Yuan , World Journal of Surgical Oncology, 2016
Feras Abu Saadeh, VTE in gynaecological cancer - who is at risk and when?, The Irish Society of Gynaecological Oncology (ISGO) Annual Scientific Meeting Dublin, Ireland. December 2016, Ireland, 2016, 2016
Feras Abu Saadeh, Risk Factors for Venous Thromboembolism (VTE) in Cancer Patients Receiving Chemotherapy, Review of Risk Factors for Venous Thromboembolism (VTE) in Cancer Patients Receiving Chemotherapy, Journal of Community and Supportive Oncology, 2016
Feras Abu Saadeh, Preoperative Differentiation between Malignant and Benign Ovarian Masses in Patients with Normal CA-125 Levels, Review of Preoperative Differentiation between Malignant and Benign Ovarian Masses in Patients with Normal CA-125 Levels, International Journal of Cancer and Clinical Research, 2016
Feras Abu Saadeh, Hyperthermic Intraoperative Intraperitoneal Chemotherapy (HIPEC): its place in gynaecological oncology, Review of Hyperthermic Intraoperative Intraperitoneal Chemotherapy (HIPEC): its place in gynaecological oncology, o Journal of Cancer Biology & Research, 2016
Feras Abu Saadeh, Interactive session on cancer and thrombosis, Junior Obstetrics and Gynaecology Society Meeting , Ireland, 2016
Feras Abu Saadeh, Aggressive angiomyxoma of the pelvis: dramatic response to chemical ablation therapy, Review of Aggressive angiomyxoma of the pelvis: dramatic response to chemical ablation therapy, by Chuang He; Yang Li; Yun Liu; Li Yang; De-yu Guo; xuequan huang , BMC Women's Health, 2015
Feras Abu Saadeh, Elevated preoperative plasma D‑dimer levels show correlation with poor prognosis in serous ovarian cancer patients with absence of venous thromboembolism (VTE), Review of Elevated preoperative plasma D‑dimer levels show correlation with poor prognosis in serous ovarian cancer patients with absence of venous thromboembolism (VTE), Biomarkers, 2015
Feras Abu Saadeh, Make ureter your friend, 3rd Irish Congress of Obstetrics Gynaecology and perinatal medicine, Ireland, 2015
Feras Abu Saadeh, Role of surgery in ovarian cancer, Ovarian Cancer Patient Day, Ireland, 2015
Feras Abu Saadeh, Cancer and thrombosis, Gynaecological Traveller, Ireland, 2014
Feras Abu Saadeh, Venous thromboembolism Gynaecological Cancer - Risk, Pathogenesis and Clinical Significance" , Master class on thrombosis and cancer/ Trinity College Dublin , Ireland, 2013
Edward Barrett and Marie Redmond, Contextual Media, USA, MIT Press, 1997
Research Expertise
Projects
- Title
- A risk model for prediction of venous thromboembolism in gynaecological cancer patients post surgery
- Summary
- Venous thromboembolism (VTE) is a common cause of death in patients with solid tumours. Cancer itself causes a hypercoagulable state, in addition chemotherapy and surgery enhance the risk. Gynaecological cancers have been associated with high rates of VTE which is excacerbated by pelvic surgery and chemotherapy. A recent study in our centre showed that one third of VTE in ovarian cancer patients occurs within 5 days of surgery despite heparin prophylaxis. Recently, clinical risk models have been developed to predict VTE in patients undergoing chemotherapy, these models have been shown to be more powerful when combined with haemostatic biomarkers. Thrombus formation is complex in cancer and is thought to result from a release of procoagulant material from the tumour combined with damage to the endothelium as a result of chemotherapy and surgery. Global tests of hypercoagulability which capture these effects are therefore attractive as determinants of thrombotic risk. Calibrated automated thrombograpy (CAT) is a recently developed global test which measures thrombin generation in plasma. Increased thrombin generation is predictive of VTE in a variety of clinical settings. The overarching aim of this project is to develop and validate a specific risk scoring model for VTE risk in gynaecological cancer patients using a combination of easily available clinical and laboratory parameters and haemostatic biomarkers. In a large population of gynaecological cancer patients, we will identify the key risk factors for VTE and use them to derive a risk score model. Based on our pilot data, we believe that a thrombin generation test may be a useful biomarker for VTE in gynaecological cancer. By understanding the mechanisms by which gynaecological cancer increases procoagulant activity, we will optimise a specific thrombin generation assay which when combined with the derived risk score model will accurately identify gynaecological cancer patients at high risk of VTE.
- Funding Agency
- HRB
- Date From
- 2013
- Date To
- 2017
- Title
- Towards increased awareness and understanding of the risk of thrombosis in gynaecological cancers
- Summary
- A recent survey of patients who suffered a thrombosis during their cancer journey showed that, generally, patients are not warned about the risk of clots during cancer and are not told what to look out for. In addition research by our group has shown that only 45% of gynaecologists in Europe are using the correct guidelines for thrombosis prevention. The aim of this project is to increase awareness among patients regarding thrombosis and to provide an opportunity for knowledge exchange between gynaecologist and scientists working in the area
- Funding Agency
- HRB
- Date From
- 2015
- Date To
- 2017
- Title
- Gynaecological cancer patients experience of extended LMWH prophylaxis post surgery.
- Summary
- Venous thromboembolism (VTE) is a common post-operative complication in cancer patients associated with high mortality rates. The presence of a gynaecological malignancy increases the rate of post operative VTE fourfold compared with patients with benign disease. Among cancer patients who develop a venous thromboembolism postoperatively, 40% will do so 21 days after surgery(1). Among endometrial cancer patients diagnosed with venous thromboembolism, a recent study of a large national quality database found that 73% of minimally invasive surgery and 43% of open surgery patients are diagnosed with a venous thromboembolism after hospital discharge (2). In line with these findings, the American College of Chest Physicians recommends the use of extended duration prophylaxis for patients with cancer undergoing abdomino-pelvic surgery (3). From May 2012, all patients undergoing surgery for a gynaecological malignancy in our centre receive 28 days extended LMWH prophylaxis post surgery. Studies in other centres have reported that translation of the guidelines for prophylaxis into clinical practice has been problematic (4). Introduction of extended prophylaxis is an additional burden on the cancer patient as they are responsible for purchasing, and in many cases, self-injecting the medication. Additional educational and support services are also required in the community for these patients. In other patient groups, lack of education and a negative opinion toward injection has affected compliance (5). The cancer patient may have additional difficulty as they are managing multiple symptoms and treatments. Among gynaecological cancer patients, the patient experience of extended prophylaxis has not been documented and compliance is largely unknown.
- Funding Agency
- LeoPharma
- Date From
- 2018
- Date To
- 2019
- Title
- A study to determine the effects of extended (28 days) LMWH prophylaxis on the incidence of venous thromboembolism in gynaecological cancer patients post surgery- 5 year review.
- Summary
- Gynaecological cancers, and in particular adenocarcinomas are associated with a very high risk of venous thromboembolism (VTE) with rates as high as 42% reported for clear cell cancer of the ovary . Patients are particularly at risk during the postoperative period where VTE occurs in 6-7% of patients despite LMWH prophylaxis. In addition, recent evidence has suggested that a substantial proportion of VTE occurs beyond hospital stay. Among gynaecological cancer patients who develop VTE, 40% occur > 21 days post surgery . Minimally invasive surgery is increasingly used for gynaecological cancer surgery, although this has significantly reduced the incidence of VTE, it has not eliminated this risk post surgery [4. Among patients who suffer a VTE following minimally invasive surgery for endometrial cancer, 73% were diagnosed with a VTE after discharge compared with 43% for open surgery patients. The mean time to VTE was 10 days for minimally invasive surgery and 14 days for open surgery patients. A randomised trial comparing 28 days prophylaxis with LMWH following major abdominal surgery for cancer with 7 days prophylaxis showed a 60% reduction in VTE in the extended prophylaxis group without any substantial risk of bleeding.
- Funding Agency
- LeoPharma
- Date From
- 2018
- Date To
- 2020
- Title
- Lymph node metastasis and thrombosis risk in Gynaecological cancer patients post surgery
- Summary
- Gynaecological cancer is associated with an increased incidence of venous thromboembolism (VTE) even with appropriate thromboprophylaxis. The risk is greatest following surgery and can persist for up to 6-12 months post surgery. The focus of our research group is to determine clinical and haemostatic biomarkers for VTE post surgery in order to identify high risk gynaecological cancer patients who may benefit from more tailored LMWH prophylaxis Lymph node dissection (LND) is a common procedure in gynaecological cancer surgery and increases the complications and complexity of the surgery. Reports in other cancers suggest an association between lymph node metastasis and post operative thrombo embolic complications. However there is very little data on gynaecological cancers. In addition, none of the current risk scores for thrombosis account for LND, The aim of our study is to investigate the role of lymph node metastasis in VTE following both open and laparoscopic surgery for gynaecological cancer.
- Funding Agency
- LeoPharma
- Date From
- 2019
- Date To
- 2021
Recognition
Representations
Editorial Board of Advances in Modern Oncology Research
Medical Advisory Board of OvaCare
Editorial Board of International Journal of Gynecology & Clinical Practice
National representative at ENYGO
Chair the session on women cancer and thrombosis of The 7th International Symposium on Women's Health Issues in Thrombosis and Haemostasis (WITH)
forum/dicussion group Expert meeting, Thrombosis in women with cancer
Member of the National Cancer Control Programme guideline group
Awards and Honours
1st Class honours, Medicine, Surgery, Paediatrics, Obstetrics and Gynaecology
Best oral presentation, ICOGPM
Best oral presentation, JOGS
Memberships
Member of Royal College of Obstetrician & Gynaecologist
National representative at European Network of Young Gynaecological Oncology
Member of Royal College of Physicians of Ireland
Member of Irish Medical Council "Full Registration"
Member of British Society of Colposcopy and Cervical Pathology
Member of International Society of Ultrasound in Obsetrics & Gynaecology
Member of European Society of Gynaecological Oncology
Member of Jordan Medical Association "Full Registration"
Member and Founder of Palestinian Society of Obstetrics & Gynaecology