Professor Cliona O'Farrelly
Chair in Comparative Immunology, Biochemistry
Chair in Comparative Immunology, Clinical Medicine
Publications and Further Research Outputs
Peer-Reviewed Publications
Ridge, Katie and Moran, Barry and Alvarado-Vazquez, P. Abigail and Hallgren, Jenny and Little, Mark A. and Irvine, Alan D. and O'Farrelly, Cliona and Dunne, Jean and co-senior). Finlay, Conor M (co-corresponding & and Conlon, Niall, Lin-CD117+CD34+FceRI+ progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti-IgE therapy, Allergy, In Press, 2024
Bertrand A, Sugrue J, Lou T, Bourke N.M, Quintana-Murci L, Saint-André V, O'Farrelly C, Duffy D, Impact of socioeconomic status on healthy immune responses in humans, Immunology and Cell Biology, 2024
Sularea V.M, Sugrue J.A, O'Farrelly C, Innate antiviral immunity and immunometabolism in hepatocytes, Current Opinion in Immunology, 80, 2023
Villain E, Chanson A, Mainka M, Kampschulte N, Le Faouder P, Bertrand-Michel J, Brandolini-Bulon M, Charbit B, Musvosvi M, Bilek N, Scriba T.J, Quintana-Murci L, Schebb N.H, Duffy D, Gladine C, Abel L, Alcover A, Aschard H, Bousso P, Bourke N, Brodin P, Bruhns P, Cerf-Bensussan N, Cumano A, D'Enfert C, Deriano L, Dillies M.-A, Di Santo J, Eberl G, Enninga J, Fellay J, Gomperts-Boneca I, Hasan M, Hedestam G.K, Hercberg S, Ingersoll M.A, Lantz O, Kenny R.A, Ménager M, Mouquet H, O'Farrelly C, Patin E, Pellegrini S, Rausell A, Rieux-Laucat F, Rogge L, Fontes M, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Tangy F, Toubert A, Touvier M, Ungeheuer M.-N, Zimmer C, Albert M.L, Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks, iScience, 26, (8), 2023
Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Emily Killeen, Conal Gallagher, Naomi Davey, Eimear Connolly, Shane Lyons, Conor Young, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Nollaig M Bourke, Aoife Fallon, Sean O'Dowd, Sean P Kennelly, Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration, BMJ Open, 2023
Ahmed O, Xu M, Zhou F, Wein A.N, Upadhya G, Ye L, Wong B.W, Lin Y, O'Farrelly C, Chapman W.C, NRF2 assessment in discarded liver allografts: A role in allograft function and salvage, American Journal of Transplantation, 22, (1), 2022, p58 - 70
Crosby D.A, Glover L.E, Downey P, Mooney E.E, McAuliffe F.M, O'Farrelly C, Brennan D.J, Wingfield M, Mid-luteal uterine artery Doppler indices in the prediction of pregnancy outcome in nulliparous women undergoing assisted reproduction, Human Fertility, 25, (4), 2022, p670 - 676
Sugrue JA, Posseme C, Tan Z, Pou C, Charbit B, Bondet V, Bourke NM, Brodin P, Duffy D, O'Farrelly C, Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort., Cell reports. Medicine, 2022
Posseme, Celine and Llibre, Alba and Charbit, Bruno and Bondet, Vincent and Rouilly, Vincent and Saint-André, Violaine and Boussier, Jeremy and Bergstedt, Jacob and Smith, Nikaïa and Townsend, Liam and Sugrue, Jamie A and Nà Cheallaigh, ClÃona and Conlon, Niall and Rotival, Maxime and Kobor, Michael S and Mottez, Estelle and Pol, Stanislas and Patin, Etienne and Albert, Matthew L and Quintana-Murci, Lluis and Duffy, Darragh and {Milieu Intérieur Consortium, Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation, Cell reports, 39, (13), 2022, p110989
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236
Carroll H.K, Duffy A.G, O'Farrelly C, Liver Immunology, Immunotherapy, and Liver Cancers: Time for a Rethink?, Seminars in Liver Disease, 42, (2), 2022, p212 - 224
Dyer AH, Noonan C, McElheron M, Batten I, Reddy C, Connolly E, Pierpoint R, Murray C, Leonard A, Higgins C, Reilly P, Boran G, Phelan T, McCormack W, O'Neill D, Fallon A, Brady G, O'Farrelly C, Bourke NM, Kennelly SP., Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents, Journal of the American Medical Directors Association, 2022
Dyer AH, Fallon A, Noonan C, Dolphin H, O'Farrelly C, Bourke NM, O'Neill D, Kennelly SP, Managing The Impact Of COVID-19 in Nursing Homes and Long-Term Care Facilities: An Update, Journal of the American Medical Directors Association, 2022
Kelly, P. and Meade, K.G. and O'Farrelly, C., Non-canonical inflammasome-mediated IL-1β production by primary endometrial epithelial and stromal fibroblast cells is NLRP3 and caspase-4 dependent, Frontiers in Immunology, 10, (FEB), 2019, p1--
Meade, K.G. and O'Farrelly, C., Î'-Defensins: Farming the microbiome for homeostasis and health, Frontiers in Immunology, 10, (JAN), 2019
Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346
*Galvin KC, *Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J., Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma., Cancer Letters, 418, 2018, p230-238
Glover, L.E. and Crosby, D. and Thiruchelvam, U. and Harmon, C. and Chorcora, C.N. and Wingfield, M.B. and O'Farrelly, C., Uterine natural killer cell progenitor populations predict successful implantation in women with endometriosis-associated infertility, American Journal of Reproductive Immunology, 2018, pe12817-
Roche, J., Davis, N., Chaikovsky, M., O'Boyle, S., & O'Farrelly, C., European Researchers' Night as a Learning Environment, The International Journal of Interdisciplinary Educational Studies, 13, (1), 2018, p1 - 9
Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216
Adnane, M. and Kelly, P. and Chapwanya, A. and Meade, K.G. and O'Farrelly, C., Improved detection of biomarkers in cervico-vaginal mucus (CVM) from postpartum cattle, BMC Veterinary Research, 14, (1), 2018
Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764
Adnane, M. and Chapwanya, A. and Kaidi, R. and Meade, K.G. and O'Farrelly, C., Profiling inflammatory biomarkers in cervico-vaginal mucus (CVM) postpartum: Potential early indicators of bovine clinical endometritis?, Theriogenology, 103, 2017, p117-122
Hall, T.J. and McQuillan, C. and Finlay, E.K. and O'Farrelly, C. and Fair, S. and Meade, K.G., Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome, BMC Genomics, 18, (1), 2017, p278-
Whiston, R. and Finlay, E.K. and McCabe, M.S. and Cormican, P. and Flynn, P. and Cromie, A. and Hansen, P.J. and Lyons, A. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., A dual targeted β-defensin and exome sequencing approach to identify, validate and functionally characterise genes associated with bull fertility, Scientific Reports, 7, (1), 2017, p12287 -
Kennelly, K.P. and Holmes, T.M. and Wallace, D.M. and Oâ Farrelly, C. and Keegan, D.J., Early subretinal allograft rejection is characterized by innate immune activity, Cell Transplantation, 26, (6), 2017, p983-1000
Garvey, P. and Murphy, N. and Flanagan, P. and Brennan, A. and Courtney, G. and Crosbie, O. and Crowe, J. and Hegarty, J. and Lee, J. and McIver, M. and McNulty, C. and Murray, F. and Nolan, N. and O'Farrelly, C. and Stewart, S. and Tait, M. and Norris, S. and Thornton, L., Disease outcomes in a cohort of women in Ireland infected by hepatitis C-contaminated anti-D immunoglobulin during 1970s, Journal of Hepatology, 67, (6), 2017, p1140-1147
Fischer J, Weber A.N.R, Bohm S, Dickhöfer S, El Maadidi S, Deichsel D, Knop V, Klinker H, Möller B, Rasenack J, Wang L, Sharma M, Hinrichsen H, Spengler U, Buggisch P, Sarrazin C, Pawlita M, Waterboer T, Wiese M, Probst-MÃ"ller E, Malinverni R, Bochud P.-Y, Gardiner C, O'Farrelly C, Berg T, Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection, Gut, 2016
Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan D.D, Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance?, American Journal of Transplantation, 16, (3), 2016, p751 - 757
Conroy M.J, Fitzgerald V, Doyle S.L, Channon S, Useckaite Z, Gilmartin N, Oâ Farrelly C, Ravi N, Reynolds J.V, Lysaght J, The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function, Journal of Leukocyte Biology, 100, (6), 2016, p1435 - 1442
Coughlan A.M, Harmon C, Whelan S, O'Brien E.C, O'Reilly V.P, Crotty P, Kelly P, Ryan M, Hickey F.B, O'Farrelly C, Little M.A, Myeloid engraftment in humanized mice: Impact of granulocyte-colony stimulating factor treatment and transgenic mouse strain, Stem Cells and Development, 25, (7), 2016, p530 - 541
Johnson G.P, Lloyd A.T, O'Farrelly C, Meade K.G, Fair S, Comparative genomic identification and expression profiling of a novel β-defensin gene cluster in the equine reproductive tract, Reproduction, Fertility and Development, 28, (10), 2016, p1499 - 1508
Doherty R, Whiston R, Cormican P, Finlay E.K, Couldrey C, Brady C, O'Farrelly C, Meade K.G, The CD4 + T cell methylome contributes to a distinct CD4 + T cell transcriptional signature in Mycobacterium bovis-infected cattle, Scientific Reports, 6, 2016, p31014
Kelly A, Robinson M.W, Roche G, Biron C.A, O'Farrelly C, Ryan E.J, Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway, Journal of Interferon and Cytokine Research, 36, (12), 2016, p671 - 680
Harmon C, Robinson M.W, Fahey R, Whelan S, Houlihan D.D, Geoghegan J, O'Farrelly C, Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver, European Journal of Immunology, 46, (9), 2016, p2111 - 2120
Robinson M.W, Harmon C, O'Farrelly C, Liver immunology and its role in inflammation and homeostasis, Cellular and Molecular Immunology, 13, (3), 2016, p267 - 276
Thiruchelvam U, Wingfield M, O'Farrelly C, Increased uNK Progenitor Cells in Women With Endometriosis and Infertility are Associated With Low Levels of Endometrial Stem Cell Factor, American Journal of Reproductive Immunology, 75, (4), 2016, p493 - 502
Fernandez-Fuertes, B. and Narciandi, F. and O'Farrelly, C. and Kelly, A.K. and Fair, S. and Meade, K.G. and Lonergan, P., Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle, Biology of Reproduction, 95, (6), 2016, p1-12
Rush G, O'Donovan A, Nagle L, Conway C, McCrohan A, O'Farrelly C, Lucey J.V, Malone K.M, Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy, Journal of Affective Disorders, 205, 2016, p60 - 68
Narciandi, F. and Fernandez-Fuertes, B. and Khairulzaman, I. and Jahns, H. and King, D. and Finlay, E.K. and Mok, K.H. and Fair, S. and Lonergan, P. and O'Farrelly, C. and Meade, K.G., Sperm-coating beta-defensin 126 is a dissociation-resistant dimer produced by epididymal epithelium in the bovine reproductive tract, Biology of Reproduction, 95, (6), 2016, p1-9
Conroy M.J, Galvin K.C, Kavanagh M.E, Mongan A.M, Doyle S.L, Gilmartin N, O'Farrelly C, Reynolds J.V, Lysaght J, CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer, Immunology and Cell Biology, 94, (6), 2016, p531 - 537
Murphy, T.M. O'Donovan, A. Mullins, N. O'Farrelly, C. McCann, A. Malone, K., Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes, Psychiatric Genetics, 25, (2), 2015, p71 - 78
Foley C, Chapwanya A, Callanan JJ, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer WG, Lynn DJ, O' Farrelly C, Meade KG, Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis., BMC genomics, 16, 2015, p811
Foley C, Chapwanya A, Callanan J.J, Whiston R, Miranda-CasoLuengo R, Lu J, Meijer W.G, Lynn D.J, O'Farrelly C, Meade K.G, Erratum to: 'Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis'[BMC Genomics. 2015;16:811.], 2015, -
Thiruchelvam U, Wingfield M, O'Farrelly C, Natural Killer Cells: Key Players in Endometriosis, American Journal of Reproductive Immunology, 74, (4), 2015, 291-301
Fitzmaurice K, Hurst J, Dring M, Rauch A, McLaren P.J, GÌnthard H.F, Gardiner C, Klenerman P, Courtney G, Crosbie O, Crowe J, Fanning L, Hegarty J, Kelleher D, Lawlor E, Lee J, McKiernan S, Murray F, Norris S, O'Farrelly C, Thornton L, Aubert V, Battegay M, Bernasconi E, Böni J, Bucher H.C, Burton-Jeangros C, Calmy A, Cavassini M, Egger M, Elzi L, Fehr J, Fellay J, Furrer H, Fux C.A, Gorgievski M, Haerry D, Hasse B, Hirsch H.H, Hösli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kouyos R, Kovari H, Ledergerber B, Martinetti G, Martinez De Tejada B, Metzner K, MÌller N, Nadal D, Pantaleo G, Regenass S, Rickenbach M, Rudin C, Schöni-Affolter F, Schmid P, Schultze D, SchÌpbach J, Speck R, Tarr P, Telenti A, Trkola A, Vernazza P, Weber R, Yerly S, Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection, Gut, 64, (5), 2014, p813 - 819
Kelly, A., Fahey, R., Fletcher, J.M., Keogh, C., Carroll, A.G., Siddachari, R., Geoghegan, J., Hegarty, J.E., Ryan, E.J., O'Farrelly, C., CD141+ myeloid dendritic cells are enriched in healthy human liver, Journal of Hepatology, 60, (1), 2014, p135-142
Meade, K.G., Cormican, P., Narciandi, F., Lloyd, A., O'Farrelly, C., Bovine β-defensin gene family: Opportunities to improve animal health?, Physiological Genomics, 46, (1), 2014, p17-28
Collins, A.S. Ahmed, S. Napoletano, S. Schroeder, M. Johnston, J.A. Hegarty, J.E. O'Farrelly, C. Stevenson, N.J., Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-- responses, Journal of Leukocyte Biology, 96, (2), 2014, p255 - 263
Morrison, M.H., Keane, C., Quinn, L.M., (...), Bergin, C., Gardiner, C.M., IFNL cytokines do not modulate human or murine NK cell functions, Human Immunology, 75, (9), 2014, p996-1000
Kelly, Aoife Ryan, Elizabeth J. O'Farrelly, Cliona, Reply to: "Dendritic cell subset composition in the human liver is more complex than it seems", Journal of Hepatology, 60, (5), 2014, p1098-1099
Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204-
Kelly, A, Fahey, R, Fletcher, JM, Keogh, C, Carroll, AG, Siddachari, R, Geoghegan, J, Hegarty, JE, Ryan, EJ, O'Farrelly, C, CD141(+) myeloid dendritic cells are enriched in healthy human liver, JOURNAL OF HEPATOLOGY, 60, (1), 2014, p135-142
Lawless, N., Reinhardt, T.A., Bryan, K., (...), Lippolis, J., Lynn, D.J., Microrna regulation of bovine monocyte inflammatory and metabolic networks in an in Vivo infection model, G3: Genes, Genomes, Genetics, 4, (6), 2014, p957-971
Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050
Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63
Lawless, N. Vegh, P. O'Farrelly, C. Lynn, D.J., The role of microRNAs in bovine infection and immunity, Front. Immunol., 5, (NOV), 2014, p611-
McLoughlin KE, Nalpas NC, Rue-Albrecht K, Browne JA, Magee DA, Killick KE, Park SD, Hokamp K, Meade KG, O'Farrelly C, Gormley E, Gordon SV, MacHugh DE, RNA-seq Transcriptional Profiling of Peripheral Blood Leukocytes from Cattle Infected with Mycobacterium bovis., Frontiers in immunology, 5, 2014, p396
Whelehan, CJ, Barry-Reidy, A, Meade, KG, Eckersall, PD, Chapwanya, A, Narciandi, F, Lloyd, AT, O'Farrelly, C, Characterisation and expression profile of the bovine cathelicidin gene repertoire in mammary tissue, BMC GENOMICS, 15, 2014, p128-
Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050
Killick, K.E., Ní Cheallaigh, C., O'Farrelly, C., (...), Machugh, D.E., Harris, J., Receptor-mediated recognition of mycobacterial pathogens, Cellular Microbiology, 15, (9), 2013, p1484-1495
O'Donovan, A., Rush, G., Hoatam, G., Hughes, B.M., McCrohan, A., Kelleher, C., O'Farrelly, C., Malone, K.M., Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder, Depression and Anxiety , 30, (4), 2013, p307-314
Lawless N, Foroushani AB, McCabe MS, O'Farrelly C, Lynn DJ, Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection., PloS one, 8, (3), 2013, pe57543
Connell, S, Meade, KG, Allan, B, Lloyd, AT, Downing, T, O'Farrelly, C, Bradley, DG, Genome-Wide Association Analysis of Avian Resistance to Campylobacter jejuni Colonization Identifies Risk Locus Spanning the CDH13 Gene, G3-GENES GENOMES GENETICS, 3, (5), 2013, p881-890
Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578
Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090
Doherty, R., O'Farrelly, C., Meade, K.G., Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC), Veterinary Immunology and Immunopathology, 154, (3-4), 2013, p102-110
Klintmalm, G., O'Farrelly, C., Taking the rap: Multiple effects of blocking mammalian target of rapamycin, Hepatology, 57, (1), 2013, p1-3
Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial epithelial cells are potent producers of tracheal antimicrobial peptide and serum amyloid A3 gene expression in response to E. coli stimulation, Veterinary Immunology and Immunopathology , 151, (1-2), 2013, p157-162
Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ, miR-19a: An Effective Regulator of SOCS3 and Enhancer of JAK-STAT Signalling., PloS one, 8, (7), 2013, pe69090
Narciandi F, Lloyd A, Meade KG, O'Farrelly C, A novel subclass of bovine ?-defensins links reproduction and immunology., Reproduction, fertility, and development, 2013
Lawless, N., Foroushani, A.B.K., McCabe, M.S., O'Farrelly, C., Lynn, D.J., Next Generation Sequencing Reveals the Expression of a Unique miRNA Profile in Response to a Gram-Positive Bacterial Infection, PLoS ONE, 8, (3), 2013, part. no. e57543
Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ, Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection., Cytokine, 60, (2), 2012, p328-33
Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J, Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy., American journal of reproductive immunology (New York, N.Y. : 1989), 67, (1), 2012, p9-16
Chapwanya A, Meade KG, Foley C, Narciandi F, Evans AC, Doherty ML, Callanan JJ, O'Farrelly C, The postpartum endometrial inflammatory response: a normal physiological event with potential implications for bovine fertility., Reproduction, fertility, and development, 24, (8), 2012, p1028-1039
Connell S, Meade KG, Allan B, Lloyd AT, Kenny E, Cormican P, Morris DW, Bradley DG, O'Farrelly C, Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing., PloS one, 7, (8), 2012, pe40409
McMenamin M, Lysakova-Devine T, Wingfield M, O'Herlihy C, O'Farrelly C, Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells., Reproductive biomedicine online, 25, (3), 2012, p322-328
Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG, Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows., BMC genomics, 13, (1), 2012, p489
Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production., Immunity, 37, (3), 2012, p574-87
Sarwar S, Ryan EJ, Iqbal M, McCormick PA, O'Farrelly C, Hegarty J, Rapid, early and sustained virological responses in a cohort of Irish patients treated with pegylated interferon and ribavirin for chronic hepatitis C virus infection., Irish journal of medical science, 181, (1), 2012, p53-58
Meade KG, O'Gorman GM, Narciandi F, Machugh DE, O'Farrelly C, Functional characterisation of bovine interleukin 8 promoter haplotypes in vitro., Molecular immunology, 50, (1-2), 2012, p108-116
Ronan G. Shaughnessy, Kieran G. Meade, Beatrice A. McGivney, Brenda Allan, Cliona O' Farrelly, Global gene expression analysis of chicken caecal response to Campylobacter jejuni, Veterinary Immunology and Immunopathology, 142, (1-2), 2011, p64-71
Cormac J. Whelehan, Kieran G. Meade, P. David Eckersall, Fiona J. Young, Cliona O'Farrelly, EXPERIMENTAL STAPHYLOCOCCUS AUREUS INFECTION OF THE MAMMARY GLAND INDUCES REGION-SPECIFIC CHANGES IN INNATE IMMUNE GENE EXPRESSION, Veterinary Immunology and Immunopathology, 140, (3-4), 2011, p181-189
Ceara E. Walsh, Elizabeth J. Ryan, Cliona O'Farrelly, Lucy Golden-Mason, Oliver FitzGerald, Douglas J. Veale, Barry Bresnihan, Ursula Fearon, Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease, PLoS One, 6, (11, e27182), 2011
Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866
Kate E Killick, John A Browne, Stephen DE Park, David A Magee, Irene Martin, Kieran G Meade, Stephen V Gordon, Eamonn Gormley, Cliona O'Farrelly, Karsten Hokamp and David E MacHugh, Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes, BMC Genomics , 12, (611), 2011
Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R, O'Farrelly C, Gardiner CM, Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection., PNAS, 108, (14), 2011, p5736-41
Ryan, E.J., Stevenson, N.J., Hegarty, J.E., O'Farrelly, C., Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation, Journal of Viral Hepatitis , 18, (12), 2011, p840-851
Narciandi F, Lloyd AT, Chapwanya A, O' Farrelly C, Meade KG, Reproductive tissue-specific expression profiling and genetic variation across a 19 gene bovine ß-defensin cluster., Immunogenetics, 63, (10), 2011, p641-651
Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207
Petrovic D., Stamataki Z., Dempsey E., Golden-Mason L., Freeley M., Doherty D., Prichard D., Keogh C., Conroy J., Mitchell S., Volkov Y., McKeating J.A., O'Farrelly C., Kelleher D., Long A., Hepatitis C virus targets the Tcell secretory machinery as a mechanism of immune evasion, Hepatology, 53, (6), 2011, p1846 - 1853
Foley, C., O'Farrelly, C., Meade, K.G, Technical note: Comparative analyses of the quality and yield of genomic DNA from invasive and noninvasive, automated and manual extraction methods, Journal of Dairy Science, 94, (6), 2011, p3159-3165ds
Kevin P. Kennelly, Deborah M. Wallace, Toby M. Holmes, Deborah J. Hankey, Timothy S. Grant, Cliona O'Farrelly, David J. Keegan , Preparation of Pre-Confluent Retinal Cells Increases Graft Viability In Vitro and In Vivo: A Mouse Model, PLoS One, 6, (6, e21365), 2011
Ryan, E.J., O'Farrelly, C., The affect of chronic hepatitis C infection on dendritic cell function: A summary of the experimental evidence, Journal of Viral Hepatitis, 18, (9), 2011, p601-607
Tobin, A.M., Lynch, L., Kirby, B., O'Farrelly, C., Natural killer cells in psoriasis, Journal of Innate Immunity , 3, (4), 2011, 403-410
O'Donovan, A., Hughes, B.M., Slavich, G.M., Lynch, L., Cronin, M.-T., O'Farrelly, C., Malone, K.M, Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships, Brain, Behavior, and Immunity, 24, (7), 2010, p1074-1077
O'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE , 5, (4), 2010, part. no. e9997
Ryan, E.J., Dring, M., Ryan, C.M., McNulty, C., Stevenson, N.J., Lawless, M.W., Crowe, J., Nolan, N., Hegarty, J.E., O'Farrelly, C., Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832
Downing T, Lloyd AT, O'Farrelly C, Bradley DG, The differential evolutionary dynamics of avian cytokine and TLR gene classes., Journal of immunology (Baltimore, Md. : 1950), 184, (12), 2010, p6993-7000
Tajuddin, T., Ryan, E.J., Norris, S., Hegarty, J.E., O'Farrelly, C., Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist, Journal of Gastroenterology and Hepatology, 25, (12), 2010, p1883-1890
Smith, KJ, Norris, S, O'Dwyer, AM & O'Mara, SM. , Risk factors for the development of depression in patients with Hepatitis C taking Interferon-alpha., Neuropsychiatric Disease and Treatment, 2010, p1-18
Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474
Downing, T., O'Farrelly, C., Bhuiyan, A.K., Silva, P., Naqvi, A.N., Sanfo, R., Sow, R.-S., (...), Bradley, D.G.., Variation in chicken populations may affect the enzymatic activity of lysozyme, Animal Genetics, 41, (2), 2010, p213-217
Chapwanya, A., Meade, K.G., Narciandi, F., Stanley, P., Mee, J.F., Doherty, M.L., Callanan, J.J., O'Farrelly, C., Endometrial biopsy: a valuable clinical and research tool in bovine reproduction, Theriogenology, 73, (7), 2010, p988-994
Elizabeth J. Ryan, Megan Dring, Cliona M. Ryan, Carol McNulty, Nigel J. Stevenson, Matthew W. Lawless, John Crowe, Niamh Nolan, John E. Hegarty and Cliona O'Farrelly, A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832
O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. , OAS1: a multiple sclerosis susceptibility gene that influences disease severity., Neurology, 75, (5), 2010, p411 - 418
O'Shea, D., Cawood, T.J., O'Farrelly, C., Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke., PloS one, 5, (1), 2010, e8660
Downing, T., Lynn, D.J., Connell, S., Lloyd, A.T., Bhuiyan, A.K.F.H., Silva, P., Naqvi, A.N., (...), Bradley, D.G. , Erratum: Contrasting evolution of diversity at two disease-associated chicken genes (Immunogenetics DOI: 10.1007/s00251-009-0359-x), 2009, - 421-422
Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH, CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis., Journal of Immunology , 183, (11), 2009, p7602-7610
Meade, K.G., Narciandi, F., Cahalane, S., Reiman, C., Allan, B., O'Farrelly, C., Comparative in vivo infection models yield insights on early host immune response to Campylobacter in chickens, Immunogenetics, 61, (2), 2009, p101-110
Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901
Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT, Evidence of the adaptive evolution of immune genes in chicken, BMC Research Notes, 2, (254), 2009, part. no. 254
MacHugh, D.E., Gormley, E., Park, S.D.E., Browne, J.A., Taraktsoglou, M., O'Farrelly, C., Meade, K.G., Gene expression profiling of the host response to mycobacterium bovis infection in cattle, Transboundary and Emerging Diseases , 56, (6-7), 2009, p204-214
Chapwanya, A., Meade, K.G., Doherty, M.L., Callanan, John.J., Mee, J.F., O'Farrelly, C, Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: Toward an improved understanding of uterine innate immunity, Theriogenology, 71, (9), 2009, p1396-1407
Ronan G. Shaughnessy, Kieran G. Meade, Sarah Cahalane, Brenda Allan, Carla Reiman, John J. Callanan and Cliona O' Farrelly, Innate immune gene expression differentiates the early avian intestinal response between Salmonella and Campylobacter, Veterinary Immunology and Immunopathology, 132, (2-4), 2009, p191-198
Meade, K.G., O'Gorman, G.M., Hill, E.W., Narciandi, F., Agaba, M., Kemp, S.J., O'Farrelly, C., MacHugh, D.E., Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle, Molecular Immunology, 47, (2-3), 2009, p196-204
Nemeth, E., Baird, A.W., O'Farrelly, C., Microanatomy of the liver immune system, Seminars in Immunopathology, 31, (3), 2009, p333-343
Kieran G. Meade, Rowan Higgs, Andrew T. Lloyd, Seamus Giles and Cliona O'Farrelly, Differential antimicrobial peptide gene expression patterns during early chicken embryological development , Developmental & Comparative Immunology, 33, (4), 2009, p516-524
Lynch, L.A., O'Connell, J.M., Kwasnik, A.K., Cawood, T.J., O'Farrelly, C., O'Shea, D.B., Are natural killer cells protecting the metabolically healthy obese patient?, Obesity, 17, (3), 2009, p601-605
Downing T, Lynn DJ, Connell S, Lloyd AT, Bhuiyan AK, Silva P, Naqvi AN, Sanfo R, Sow RS, Podisi B, Hanotte O, O'Farrelly C, Bradley DG, Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus., BMC Evolutionary Biology, 9, 2009, part. no. 136
O'Neill, L.A.J., O'Farrelly, C., The immune system as an invisible, silent Grand Fugue, Nature Immunology, 10, (10), 2009, p1043-1045
Cormican P, Lloyd AT, Downing T, Connell SJ, Bradley D, O'Farrelly C, The avian Toll-Like receptor pathway--subtle differences amidst general conformity., Developmental and comparative immunology, 33, (9), 2009, p967-73
Mcgrath, E., Ryan, E.J., Lynch, L., Golden-Mason, L., Mooney, E., Eogan, M., O'herlihy, C., O'Farrelly, C., Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility, American Journal of Reproductive Immunology, 61, (4), 2009, p265-276
Downing, T, Lynn, DJ, Connell, S, Lloyd, AT, Bhuiyan, AF, Silva, P, Naqvi, AN, Sanfo, R, Sow, RS, Podisi, B, O'Farrelly, C, Hanotte, O, Bradley, DG, Contrasting evolution of diversity at two disease-associated chicken genes., Immunogenetics, 61, (1), 2009, p303 - 314
Nanda, K.S., Ryan, E.J., Murray, B.F., Brady, J.J., McKenna, M.J., Nolan, N., O'Farrelly, C., Hegarty, J.E., Effect of Chronic Hepatitis C Virus Infection on Bone Disease in Postmenopausal Women, Clinical Gastroenterology and Hepatology, 7, (8), 2009, p894-899
Meade, KG, Gormley, E, O'Farrelly, C, Park, SD, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC genomics, 9, (447), 2008
Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8
Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40
Meade, KG, Cahalane, S, Narciandi, F, Cormican, P, Lloyd, AT, O'Farrelly, C, Directed alteration of a novel bovine beta-defensin to improve antimicrobial efficacy against methicillin-resistant Staphylococcus aureus (MRSA)., International journal of antimicrobial agents, 32, (5), 2008, p392-397
Cormican, P, Meade, KG, Cahalane, S, Narciandi, F, Chapwanya, A, Lloyd, AT, O'Farrelly, C, Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins., Immunogenetics, 60, (3-4), 2008, p147-156
Davies D, Meade KG, Herath S, Eckersall PD, Gonzalez D, White JO, Conlan RS, O'Farrelly C, Sheldon IM, Toll-like receptor and antimicrobial peptide expression in the bovine endometrium., Reproductive biology and endocrinology : RB&E, 6, 2008, p53
Meade KG, Gormley E, O'Farrelly C, Park SD, Costello E, Keane J, Zhao Y, Machugh DE., Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program., BMC Genomics, 29, (9), 2008, p447-
Golden-Mason, L, Castelblanco, N, O'Farrelly, C, Rosen, HR, Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection., Journal of virology, 81, (17), 2007, p9292-9298
Zaman, MB, Leonard, MO, Ryan, EJ, Nolan, NP, Hoti, E, Maguire, D, Mulcahy, H, Traynor, O, Taylor, CT, Hegarty, JE, Geoghegan, JG, O'Farrelly, C, Lower expression of Nrf2 mRNA in older donor livers: a possible contributor to increased ischemia-reperfusion injury?, Transplantation, 84, (10), 2007, p1272-8
Lynch, L, Golden-Mason, L, Eogan, M, O';Herlihy, C, O'Farrelly, C, Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?, Human reproduction (Oxford, England), 22, (4), 2007, p919-26
Meade, KG, Gormley, E, Doyle, MB, Fitzsimons, T, O'Farrelly, C, Costello, E, Keane, J, Zhao, Y, MacHugh, DE, Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease., BMC genomics, 8, 2007, p400
Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72
Cawood, TJ, Moriarty, P, O'Farrelly, C, O'Shea, D, The effects of tumour necrosis factor-alpha and interleukin1 on an in vitro model of thyroid-associated ophthalmopathy; contrasting effects on adipogenesis., European journal of endocrinology / European Federation of Endocrine Societies, 155, (3), 2006, p395-403
Volkov, Y, Long, A, Freeley, M, Golden-Mason, L, O'Farrelly, C, Murphy, A, Kelleher, D, The hepatitis C envelope 2 protein inhibits LFA-1-transduced protein kinase C signaling for T-lymphocyte migration., Gastroenterology, 130, (2), 2006, p482-92
Canny, G, Drudy, D, Macmathuna, P, O'Farrelly, C, Baird, AW, Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical., Life Sciences, 78, (9), 2006, p920-5
Leonard, MO, Kieran, NE, Howell, K, Burne, MJ, Varadarajan, R, Dhakshinamoorthy, S, Porter, AG, O'Farrelly, C, Rabb, H, Taylor, CT, Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006
Higgs, R, Cormican, P, Cahalane, S, Allan, B, Lloyd, AT, Meade, K, James, T, Lynn, DJ, Babiuk, LA, O'farrelly, C, Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection., Infection and immunity, 74, (3), 2006, p1692-
Kelly, AM, Golden-Mason, L, Traynor, O, Geoghegan, J, McEntee, G, Hegarty, JE, O'Farrelly, C, Changes in hepatic immunoregulatory cytokines in patients with metastatic colorectal carcinoma: implications for hepatic anti-tumour immunity., Cytokine, 35, (3-4), 2006, p171-9
Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204
Dean, J, McCarthy, D, Golden-Mason, L, O'Farrelly, C, Trephine biopsies are enriched for activated T/NK cells and cytotoxic T cells., Immunology letters, 99, (1), 2005, p94-102
Higgs, R, Lynn, DJ, Gaines, S, McMahon, J, Tierney, J, James, T, Lloyd, AT, Mulcahy, G, O'Farrelly, C, The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens., Immunogenetics, 57, (1-2), 2005, p90-8
Dean, J, McCarthy, D, Lawler, M, Doherty, DG, O'Farrelly, C, Golden-Mason, L, Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical immunology (Orlando, Fla.), 114, (1), 2005, p42-51
Golden-Mason, L, Kelly, AM, Doherty, DG, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development., Clinical and experimental immunology, 138, (1), 2004, p94-101
Kenna, T, Golden-Mason, L, Norris, S, Hegarty, JE, O'Farrelly, C, Doherty, DG, Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver., Clinical immunology (Orlando, Fla.), 113, (1), 2004, p56-63
Varadarajan, R, Golden-Mason, L, Young, L, McLoughlin, P, Nolan, N, McEntee, G, Traynor, O, Geoghegan, J, Hegarty, JE, O'Farrelly, C, Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation., Transplantation, 78, (2), 2004, p250-6
Carton, J, Byrne, B, Madrigal-Estebas, L, O'Donoghue, DP, O'Farrelly, C, CD4+CD8+ human small intestinal T cells are decreased in coeliac patients, with CD8 expression downregulated on intra-epithelial T cells in the active disease., European journal of gastroenterology & hepatology, 16, (10), 2004, p961-8
Kelly, AM, Golden-Mason, L, McEntee, G, Traynor, O, Doherty, DG, Hegarty, JE, O'Farrelly, C, Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo., Cytokine, 25, (6), 2004, p273-282
O'Keeffe, J, Doherty, DG, Kenna, T, Sheahan, K, O'Donoghue, DP, Hyland, JM, O'Farrelly, C, Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer., European journal of immunology, 34, (8), 2004, p2110 - 2119
Lynn, DJ, Lloyd, AT, Fares, MA, O'Farrelly, C, Evidence of positively selected sites in mammalian alpha-defensins., Molecular biology and evolution, 21, (5), 2004, p819-827
O'Farrelly, C, Immunoregulation in the liver and its extrahepatic relevance., Journal of pediatric gastroenterology and nutrition, 39 Suppl 3, 2004, pS727-S728
Golden-Mason, L, Douek, DC, Koup, RA, Kelly, J, Hegarty, JE, O'Farrelly, C, Adult human liver contains CD8pos T cells with naive phenotype, but is not a site for conventional alpha beta T cell development., Journal of immunology (Baltimore, Md. : 1950), 172, (10), 2004, p5980-5
Lynn, DJ, Higgs, R, Gaines, S, Tierney, J, James, T, Lloyd, AT, Fares, MA, Mulcahy, G, O'Farrelly, C, Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken., Immunogenetics, 56, (3), 2004, p170-177
Lynn, DJ, Lloyd, AT, O'Farrelly, C, Bioinformatics: implications for medical research and clinical practice., Clinical and investigative medicine. Médecine clinique et experimentale, 26, (2), 2003, p70-4
Hayden, PJ, O'Brien, M, Collins, B, O'Farrelly, C, Murphy, K, Inherited thrombotic tendency in a pedigree with antithrombin La Rochelle (N405K) and factor V Leiden., Clinical and laboratory haematology, 25, (3), 2003, p191 - 193
Kenna, T, Golden-Mason, L, Porcelli, SA, Koezuka, Y, Hegarty, JE, O'Farrelly, C, Doherty, DG, Mason, LG, NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells., Journal of immunology (Baltimore, Md. : 1950), 171, (4), 2003, p1775-1779
D. Brady, N. Lowe, S. Gaines L. Fenelon, J. McPartlin, C. O'Farrelly, Inhibition of S. mutans growth by hen egg derived fatty acids., J Food Sci, 68, (4), 2003, p1433-1437
Norris, S, Doherty, DG, Curry, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy., Cancer immunology, immunotherapy : CII, 52, (1), 2003, p53-8
Curry, MP, Golden-Mason, L, Doherty, DG, Deignan, T, Norris, S, Duffy, M, Nolan, N, Hall, W, Hegarty, JE, O'Farrelly, C, Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver., Journal of Hepatology, 38, (5), 2003, p642-50
Garland, M, Doherty, D, Golden-Mason, L, Fitzpatrick, P, Walsh, N, O'Farrelly, C, Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer., Anticancer research, 23, (3B), 2003, p2531 - 2535
Gaines, S, James, TC, Folan, M, Baird, AW, O'Farrelly, C, A novel spectrofluorometric microassay for Streptococcus mutans adherence to hydroxylapatite., Journal of microbiological methods, 54, (3), 2003, p315-23
Smith, F, Golden-Mason, L, Deignan, T, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, J, O'Farrelly, C, Localization of T and B lymphocytes in histologically normal adult human donor liver., Hepato-gastroenterology, 50, (53), 2003, p1311-5
Lynn, DJ, Lloyd, AT, O'Farrelly, C, In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs)., Veterinary immunology and immunopathology, 93, (3-4), 2003, p177-84
Madrigal-Estebas, L, Doherty, DG, O'Donoghue, DP, Feighery, C, O'Farrelly, C, Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells., Mediators of inflammation, 11, (5), 2002, p313-319
Deignan, T, Curry, MP, Doherty, DG, Golden-Mason, L, Volkov, Y, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection., Journal of Hepatology, 37, (1), 2002, p101-8
Byrne, B, Madrigal-Estebas, L, McEvoy, A, Carton, J, Doherty, DG, Whelan, A, Feighery, C, O'Donoghue, DP, O'Farrelly, C, Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules., Human immunology, 63, (11), 2002, p977-86
D. Brady, S. Gaines, L. Fenelon, J. Mc Partlin, C. O'Farrelly, A lipoprotein derived antimicrobial factor from hen egg yolk is active against Streptococcus species, J Food Sci , 67, (8), 2002, p3096-3103
Golden-Mason, L, O'Farrelly, C, Having it all? Stem cells, haematopoiesis and lymphopoiesis in adult human liver., Immunology and cell biology, 80, (1), 2002, p45-51
Dunne, J, Lynch, S, O'Farrelly, C, Todryk, S, Hegarty, JE, Feighery, C, Doherty, DG, Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15., Journal of immunology (Baltimore, Md. : 1950), 167, (6), 2001, p3129-38
Doherty, D.G., O'Farrelly, C., Dendritic cells: Regulators of hepatic immunity or tolerance?, Journal of Hepatology, 34, (1), 2001, p156-160
Golden-Mason, L, Kelly, AM, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Expression of interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: implications for extrathymic T cell development., Cytokine, 14, (3), 2001, p143-51
Dunne J, Lynch S, O'Farrelly C, Hegarty JE, Feighery C, Doherty DG., Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. , Journal of Immunology, 167, (6), 2001, p3129-3138
T.Deignan, A. Alwan, L. Malone, J. Kelly, C. O'Farrelly. , Hen egg yolk prevents bacterial adherence: a novel function for a familiar food. , J Food Sci , 66, 2001, p158-161
Drudy, D, O'Donoghue, DP, Baird, A, Fenelon, L, O'Farrelly, C, Flow cytometric analysis of Clostridium difficile adherence to human intestinal epithelial cells., Journal of medical microbiology, 50, (6), 2001, p526-34
Golden-Mason, L, Curry, MP, Nolan, N, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor-bearing adult human liver., Hepatology (Baltimore, Md.), 31, (6), 2000, p1251-6
Curry, MP, Norris, S, Golden-Mason, L, Doherty, DG, Deignan, T, Collins, C, Traynor, O, McEntee, GP, Hegarty, JE, O'Farrelly, C, Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization., Journal of Immunological Methods, 242, (1-2), 2000, p21-31
T. Deignan, J. Kelly, A. Alwan, C. O'Farrelly. , Comparative analysis of methods of purification of egg yolk immunoglobin (IgY). , Food Agric Immunol, 12, 2000, p77-85
Flynn, L, Byrne, B, Carton, J, Kelehan, P, O'Herlihy, C, O'Farrelly, C, Menstrual cycle dependent fluctuations in NK and T-lymphocyte subsets from non-pregnant human endometrium., American journal of reproductive immunology (New York, N.Y. : 1989), 43, (4), 2000, p209-17
Deignan, T, Alwan, A, Kelly, J, McNair, J, Warren, T, O'Farrelly, C, Serum haptoglobin: an objective indicator of experimentally-induced Salmonella infection in calves., Research in veterinary science, 69, (2), 2000, p153-8
Doherty, D.G., O'Farrelly, C., Innate and adaptive lymphoid cells in the human liver , Immunological Reviews, 174, (1), 2000, p5-20
Curry, MP, Golden-Mason, L, Nolan, N, Parfrey, NA, Hegarty, JE, O'Farrelly, C, Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection., Journal of Hepatology, 32, (1), 2000, p121-5
O'Farrelly, C, Is villous atrophy always and only the result of gluten sensitive disease of the intestine?, European journal of Gastroenterology & Hepatology, 12, (6), 2000, p605-8
Costello, P, Bresnihan, B, O'Farrelly, C, FitzGerald, O, Predominance of CD8+ T lymphocytes in psoriatic arthritis., The Journal of rheumatology, 26, (5), 1999, p1117-24.
Abuzakouk, M, Feighery, C, Kelleher, D, O'Briain, DS, Jones, E, Weir, D, Casey, E, O'Farrelly, C, Increased HLA-DR and CD44 antigen expression in the gut: evidence of extraarticular immunological activity in rheumatoid arthritis., The Journal of Rheumatology, 26, (9), 1999, p1869-76
Norris, S, Doherty, DG, Collins, C, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells., Human immunology, 60, (1), 1999, p20-31
Doherty, DG, Norris, S, Madrigal-Estebas, L, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns., Journal of immunology (Baltimore, Md. : 1950), 163, (4), 1999, p2314-21
Flynn, L, Carton, J, Byrne, B, Kelehan, P, O'Herlihy, C, O'Farrelly, C, Optimisation of a technique for isolating lymphocyte subsets from human endometrium., Immunological investigations, 28, (4), 1999, p235-46
Crosbie, OM, Reynolds, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, In vitro evidence for the presence of hematopoietic stem cells in the adult human liver., Hepatology (Baltimore, Md.), 29, (4), 1999, p1193-8
E. Healy, M. Leonard, L. Madrigal-Estebas, C. O'Farrelly, A. Watson, M. Ryan, Factors produced by activated leukocytes alter renal epithelial cell differentiation., Kidney International , 56, 1999, p1266-1269
Levelt, CN, de Jong, YP, Mizoguchi, E, O'Farrelly, C, Bhan, AK, Tonegawa, S, Terhorst, C, Simpson, SJ, High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes., Proceedings of the National Academy of Sciences of the United States of America, 96, (10), 1999, p5628-33.
Abuzakouk, M, Carton, J, Feighery, C, O'Donoghue, DP, Weir, DG, O'Farrelly, C, CD4+ CD8+ and CD8alpha+ beta- T lymphocytes in human small intestinal lamina propria., European journal of gastroenterology & hepatology, 10, (4), 1998, p325-9
Crosbie, OM, Norris, S, Hegarty, JE, O'Farrelly, C, T lymphocyte subsets and activation status in patients following liver transplantation., Immunological investigations, 27, (4-5), 1998, p237-41
Srinivasan, U, Weir, DG, Feighery, C, O'Farrelly, C, Emergence of classic enteropathy after longstanding gluten sensitive oral ulceration., BMJ (Clinical research ed.), 316, (7126), 1998, p206-7
A. Alwan, T. Deignan, M. O'Sullivan, J. Kelly, C. O'Farrelly, Quantitative assay of Salmonella adherence to intestinal epithelial cells: a new method for assessing novel intervention products., J Microbiological Methods, 33, (1), 1998, p163-170.
Feighery, C, Weir, DG, Whelan, A, Willoughby, R, Youngprapakorn, S, Lynch, S, O'Moráin, C, McEneany, P, O'Farrelly, C, Diagnosis of gluten-sensitive enteropathy: is exclusive reliance on histology appropriate?, European journal of gastroenterology & hepatology, 10, (11), 1998, p919-25
Crosbie, OM, Costello, PJ, O'Farrelly, C , Hegarty, JEC, Changes in peripheral blood double-negative T-lymphocyte (CD3+ CD4- CD8-) populations associated with acute cellular rejection after liver transplantation., Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 4, (2), 1998, p141-5
O'Farrelly C, Just how inflamed is the normal gut?, Gut, 42, (5), 1998, p603-4
Norris, S, Collins, C, Doherty, DG, Smith, F, McEntee, G, Traynor, O, Nolan, N, Hegarty, J, O'Farrelly, C, Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes., Journal of hepatology, 28, (1), 1998, p84 - 90
L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90
Norris, S, Lawler, M, McCann, S, Hegarty, J, O'Farrelly, C, Donor type microchimerism is an infrequent event following liver transplantation and is not associated with graft acceptance., Hepatology (Baltimore, Md.), 26, (4), 1997, p848-52
Srinivasan, U, Leonard, N, Jones, E, Kasarda, DD, Weir, DG, O'Farrelly, C, Feighery, C, Absence of oats toxicity in adult coeliac disease., BMJ (Clinical research ed.), 313, (7068), 1996, p1300-1
Reynolds, JV, O'Farrelly, C, Feighery, C, Murchan, P, Leonard, N, Fulton, G, O'Morain, C, Keane, FB, Tanner, WA, Impaired gut barrier function in malnourished patients., The British journal of surgery, 83, (9), 1996, p1288-1291
Abuzakouk, M, Kelleher, D, Feighery, C, O'Farrelly, C, Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?, Gut, 39, (3), 1996, p396-400
Collins, C, Norris, S, McEntee, G, Traynor, O, Bruno, L, von Boehmer, H, Hegarty, J, O'Farrelly, C, RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation., European journal of immunology, 26, (12), 1996
Abuzakouk, M, Feighery, C, O'Farrelly, C, Collagenase and Dispase enzymes disrupt lymphocyte surface molecules., Journal of immunological methods, 194, (2), 1996, p211-6.
Lynch, S, Kelleher, D, McManus, R, O'Farrelly, C, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation., European journal of immunology, 25, (5), 1995, p1143-7
S. Lynch, D. Kelleher, R. McManus and C. O'Farrelly, RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation, European journal of immunology, 25, (5), 1995, p1143-1147
J. McDevitt, C. Feighery, C. O'Farrelly, G. Martin, D.G. Weir, D.K. Kelleher. , Effects of tumour necrosis factor on BrdU incorporation in cultured human enterocytes., The Journal of Biological Chemistry, 4, 1995, p31-37
J. McDevitt, C. O'Farrelly, D.G. Weir, M. Bishr Omary, C. Feighery, D. Kelleher, Proliferation-associated marker in the coeliac duodenum, Eur J Gastroenterol Hepatol, 6, (3), 1994, p223-228
Lawler M, Humphries P, O'Farrelly C, Hoey H, Sheils O, Jeffers M, O'Briain DS, Kelleher D., Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum., Gut. , 35, (9), 1994, p1226-1232
Kelleher, D, Murphy, A, Lynch, S, O'Farrelly, C, Adhesion molecules utilized in binding of intraepithelial lymphocytes to human enterocytes., European journal of immunology, 24, (4), 1994, p1013-6
S. Lynch, D. Kelleher, C. Feighery, D. Weir, C. O'Farrelly, Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8 Ñ Ñ+cells., Eur J Gastroenterol Hepatol , 5, 1993, p907-912
Madrigal, L, Lynch, S, Feighery, C, Weir, D, Kelleher, D, O'Farrelly, C, Flow cytometric analysis of surface major histocompatibility complex class II expression on human epithelial cells prepared from small intestinal biopsies., Journal of immunological methods, 158, (2), 1993, p207-14
O'Farrelly, C, Branton, D, Wanke, CA, Oral ingestion of egg yolk immunoglobulin from hens immunized with an enterotoxigenic Escherichia coli strain prevents diarrhea in rabbits challenged with the same strain., Infection and immunity, 60, (7), 1992, p2593-7
O'Farrelly, C, O'Mahony, C, Graeme-Cook, F, Feighery, C, McCartan, BE, Weir, DG, Gliadin antibodies identify gluten-sensitive oral ulceration in the absence of villous atrophy., Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 20, (10), 1991, p476-8
O'Farrelly, C, Price, R, McGillivray, AJ, Fernandes, L, IgA rheumatoid factor and IgG dietary protein antibodies are associated in rheumatoid arthritis., Immunological investigations, 18, (6), 1989, p753-64
O'Farrelly, C, Marten, D, Melcher, D, McDougall, B, Price, R, Goldstein, AJ, Sherwood, R, Fernandes, L, Association between villous atrophy in rheumatoid arthritis and a rheumatoid factor and gliadin-specific IgG., Lancet, 2, (8615), 1988, p819-22
McCormick, PA, Feighery, C, Dolan, C, O'Farrelly, C, Kelliher, P, Graeme-Cook, F, Finch, A, Ward, K, Fitzgerald, MX, O'Donoghue, DP, Altered gastrointestinal immune response in sarcoidosis., Gut, 29, (12), 1988, p1628-31
Kelly, J, O'Farrelly, C, Rees, JP, Feighery, C, Weir, DG, Humoral response to alpha gliadin as serological screening test for coeliac disease., Archives of disease in childhood, 62, (5), 1987, p469-73
Mealy, K, O'Farrelly, C, Stephens, R, Feighery, C, Impaired neutrophil function during anesthesia and surgery is due to serum factors., The Journal of surgical research, 43, (5), 1987, p393-7
O'Farrelly, C, Graeme-Cook, F, Hourihane, DO, Feighery, C, Weir, DG, Histological changes associated with wheat protein antibodies in the absence of villous atrophy., Journal of Clinical Pathology, 40, (10), 1987, p1228-30
Kelly, J, O'Farrelly, C, O'Mahony, C, Weir, DG, Feighery, C, Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel., Clinical and experimental immunology, 68, (1), 1987, p1228-30
Watson, RG, McMillan, SA, Dolan, C, O'Farrelly, C, Cuthbert, RJ, Haire, M, Weir, DG, Porter, KG, Gliadin antibody detection in gluten enteropathy., The Ulster medical journal, 55, (2), 1986, p160-4
O'Farrelly, C, Feighery, C, O'Briain, DS, Stevens, F, Connolly, CE, McCarthy, C, Weir, DG, Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma., British medical journal (Clinical research ed.), 293, (6552), 1986, p908-10
O'Farrelly, C, McKeever, U, Feighery, C, Weir, DG, Increased concanavalin A induced suppression in treated and untreated coeliac disease., Gut, 25, (6), 1984, p644-8
O'Farrelly, C, Whelan, CA, Feighery, CF, Weir, DG, Suppressor-cell activity in coeliac disease induced by alpha-gliadin, a dietary antigen., Lancet, 2, (8415), 1984, p1305-7
O'Farrelly, C, Kelly, J, Hekkens, W, Bradley, B, Thompson, A, Feighery, C, Weir, DG, Alpha gliadin antibody levels: a serological test for coeliac disease., British medical journal (Clinical research ed.), 286, (6383), 1983, p2007-10
O'Farrelly, C, Hekkens, WT, Feighery, C, Weir, DG, The specificity of wheat protein reactivity in coeliac disease., Scandinavian journal of gastroenterology, 18, (5), 1983, p603-7
O'Farrelly, C, Feighery, C, Greally, JF, Weir, DG, Cellular response to alpha-gliadin in untreated coeliac disease., Gut, 23, (1), 1982, p83-7
Non-Peer-Reviewed Publications
Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenso, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744
Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744
A short primer on fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp15-24 , [O'Farrelly C, Doherty DG. ]
Innate immune mechanisms in the liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp41-48 , [O'Farrelly C, Doherty DG. ]
Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.]
Research Expertise
Projects
- Title
- SFI Research Frontiers 2008 08/RFP/BMT1403
- Summary
- The role of Hepatitis C Virus in regulating Signal Transducer and Activator of Transcription (STAT) protein expression to evade anti-viral Interferon-á responses.
- Funding Agency
- SFI
- Date From
- 2008
- Title
- HRB Project Grant 2007 RP/2007/278
- Summary
- Suppressor of Cytokine Signalling (SOCS) Protein Involvement in Chronic Hepatitis C Virus (HCV) Infection and Failure to Respond to Interferon Alpha Therapy
- Funding Agency
- HRB
- Date From
- 2007
- Title
- HRB Translational Research Award 2007 TRA/2007/14
- Summary
- (with Dr. Aideen Long TCD & Prof. Dermot Kelleher, TCD) Immune targeting strategies: improving the response rate to IFN-alpha/ribavirin therapy in chronic Hepatitis C Virus infection
- Funding Agency
- HRB
- Date From
- 2007
- Title
- Dept. Agriculture Research Stimulus Fund 2006 06/340
- Summary
- Structural and functional identification of candidate immune genes for resistance to mastitis and metritis
- Funding Agency
- Dept. Agriculture
- Date From
- 2006
- Title
- FIRM Grant 2006 06/RDD/486
- Summary
- Identification of genes responsible for natural host resistance to Campylobacter colonisation tools to identify and breed genetically resistant chickens
- Funding Agency
- FIRM Grant
- Date From
- 2006
- Title
- Enterprise Ireland Proof of Concept phase Winter Call 2005 PC/2005/242
- Summary
- Evolution based approaches to directed alteration of AMPs for improved efficacy against Propionibacterium acnes and MRSA
- Funding Agency
- Enterprise Ireland
- Date From
- 2005
- Title
- SFI Research Frontiers Programme 2005 05/RFP/BIC0012
- Summary
- Role of CD1d isoforms and reactive cells in regulating immune responses to malignancy
- Funding Agency
- SFI
- Date From
- 2005
- Title
- HRB Research Project Grants - General 2005 RP/2005/217
- Summary
- (with Dr. Clair Gardiner, T.C.D. & HCV Research Consortium) Investigation of KIR genotype in the resolution of HCV infection
- Date From
- 2005
- Title
- Liver Trust S.V.U.H.
- Summary
- Identification and characterisation of hepatic features prognostic of disease progress in transplant rejection and Hepatitis C
- Date From
- 2004
- Title
- FIRM Grant 2004 04/R&D/D/295
- Summary
- Functional immunogenomics in the chicken: relevance to avian influenza virus infection
- Funding Agency
- FIRM
- Date From
- 2004
- Title
- HRB Research Programme Grant 2003 BPRO/02/2003
- Summary
- Characterisation Hepatitis C Induced Immunological Subversion and its Implications for Treatment Response
- Funding Agency
- HRB
- Date From
- 2003
- Title
- Enterprise Ireland Basic Research Grant Programme 2003 SC/2003/567
- Summary
- Cytokine Milieu, Natural Killer Receptor Positive Cells, Haematopoietic Progenitors in Human Endometrium
- Funding Agency
- Enterprise Ireland
- Date From
- 2003
- Title
- HRB Research Project Grants General 2001RP141/2001
- Summary
- Adult Stem Cells: Development of T Cells in the Human Intestine
- Funding Agency
- HRB
- Date From
- 2001
- Title
- FIRM Programme Grant 200101/R&D/D/135
- Summary
- Antimicrobial activity in Hen Eggs, a Combined Bioinformatic, Biochemical and Molecular Biological Approach
- Funding Agency
- FIRM
- Date From
- 2001
- Title
- Enterprise Ireland/British Council 2000: (for promoting collaboration):
- Summary
- Adult Stem Cells in Human Liver (with Prof. A. Strain, Birmingham University)
- Funding Agency
- Enterprise Ireland/British Council
- Date From
- 2000
- Title
- HRB Project Grant 2000 RP86/2000
- Summary
- Quantification of Hepatitis C Viral load in lymphocyte subpopulations (with John Hegarty)
- Funding Agency
- HRB
- Date From
- 2000
- Title
- Enterprise Ireland Grant 1999 SC/1999/345
- Summary
- The effect of intestinal epithelial microenvironment on T cell activation (with Dr. D. O'Donoghue)
- Date From
- 1999
- Title
- Irish Cancer Society Grant 1999 CRAB 1999/2000
- Summary
- Natural T cells in human bone marrow and their role in haematopoietic malignancy (with Dr. D. McCarthy)
- Funding Agency
- Irish Cancer Society
- Date From
- 1999
- Title
- HRB (Project Grant) 1999 165/99
- Summary
- Streptococcus Mutans adherence to hydroxyapatite beads and its prevention (with Dr. L. Fenelon)
- Funding Agency
- HRB
- Date To
- 1999
- Title
- Enterprise Ireland Grant 1999 ST/1999/150
- Summary
- Characterisation of novel antimicrobial proteins for inclusion in oral healthcare products (with Mr. M. Folan)
- Funding Agency
- Enterprise Ireland
- Date From
- 1999
- Title
- HRB (Grant in aid) 1998
- Summary
- T Lymphocyte differentiation in adult human liver (with Dr. J. Hegarty)
- Funding Agency
- HRB
- Date From
- 1998
- Title
- Dept. Agriculture Functional Foods Programme
- Summary
- Novel Antibacterial factors from Hen Eggs
- Funding Agency
- Dept. Agriculture Functional Foods Programme
- Date From
- 1997
- Title
- H.R.B. (Grant-in-aid)
- Summary
- Prevention of C.difficile infection with egg (with Dr. L. Fenelon)
- Funding Agency
- HRB
- Date From
- 1997
- Title
- H.R.B. (Grant-in-aid)
- Summary
- T cell populations in the human uterus (with Prof. C.O'Herlihy)
- Funding Agency
- HRB
- Date From
- 1996
- Title
- FORBAIRT Basic Grant
- Summary
- Unconventional T lymphocytes in the intestine
- Funding Agency
- FORBAIRT
- Date From
- 1996
- Title
- H.R.B. (Grant-in-aid) 1995
- Summary
- Cytokine Elaboration by Intestinal Epithelial Cells
- Funding Agency
- HRB
- Date From
- 1995
- Title
- FORBAIRT Strategic Development Award
- Summary
- Prevention of neonatal scour using probiotic bacteria and hen egg antibodies (with Dr. M.O'Sullivan)
- Funding Agency
- FORBAIRT
- Date From
- 1994
- Title
- H.R.B. (Grant-in-aid)
- Summary
- The liver as a site of extrathymic T cell differentiation
- Funding Agency
- HRB
- Date From
- 1994
- Title
- EOLAS Higher Education Industry Co-operation grant 1994
- Summary
- EOLAS Higher Education Industry Co-operation grant 1994: Passive immunisation of pigs against scour (with Dr. J. Kelly)
- Funding Agency
- EOLAS Higher Education Industry Co-operation
- Date From
- 1994
- Title
- H.R.B. (Grant-in-aid)
- Summary
- The gastrointestinal tract: a site of extrathymic T cell differentiation
- Date From
- 1993
- Title
- EOLAS/British Council Research
- Summary
- EOLAS/British Council Research Exchange Scheme (with Dr. P. Bland) 1993
- Funding Agency
- EOLAS/British Council Research
- Date From
- 1993
- Title
- D.I.T. Strategic Research and Development Grant
- Summary
- (with Dr. J. Kelly): Passive oral immunisation of pigs against scour using specific egg immunoglobulin
- Funding Agency
- DIT
- Date From
- 1992
- Title
- H.R.B. (Fellowship)
- Summary
- Human GI epithelial cells and their role in extrathymic T lymphocyte differentiation
- Funding Agency
- HRB
- Date From
- 1991
- Title
- H.R.B. (Grant-in-aid)
- Summary
- Phenotype and functional analysis of intraepithelial lymphocytes from coeliac small intestinal biopsies
- Funding Agency
- HRB
- Date From
- 1991
- Title
- The Arthritis Foundation of Ireland,
- Summary
- Dietary Antigens and the Gut in Rheumatoid Arthritis
- Funding Agency
- The Arthritis Foundation of Ireland,
- Date From
- 1990
- Title
- H.R.B. (Grant-in-aid)
- Summary
- Antigen presentation by normal and coeliac small intestinal epithelial cells
- Funding Agency
- HRB
- Date From
- 1990
Recognition
Awards and Honours
Irish Society Immunology Public Lecture Award
Isla Haliday Memorial Lecture
Conway Lecturer and Medallist
President, Irish Society of Immunology
Thomas Davis Lecturer
Irish Research Scientists Association Gold Medal
Grave's Lecturer and Medallist
Fellow Royal Academy of Medicine of Ireland
Memberships
Irish Society of Immunology