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School of Biochemistry and Immunology

You are here Research > Groups > Inflammation Research > Publications

Selected Publications

  1. O'Neill LA. Biochemistry: succinate strikes. (2014) Nature. 20;515(7527):350-1.

  2. Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH. (2015) A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis. Mucosal Immunol. 8(5):982-92.

  3. Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA. (2015) Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. Jan 6;21(1):65-80.

  4. Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 21(3):248-55

  5. O'Neill LA. (2015) A broken krebs cycle in macrophages. Immunity.42(3):393-4

  6. Haneklaus M, O'Neill LA. (2015) NLRP3 at the interface of metabolism and inflammation. Immunol Rev. 265(1):53-62

  7. Menon D, Coll R, O'Neill LA, Board PG (2015) GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway. J Cell Sci. 128(10):1982-90.

  8. Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA (2015) Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci U S A. 112(23):7231-6.

  9. Kelly B, O'Neill LA. (2015) Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res. 25(7):771-84

  10. Netea MG, Latz E, Mills KH, O'Neill LA. (2015) Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol. 16(7):675-9

  11. Kelly B, Tannahill GM, Murphy MP, O'Neill LA. (2015) Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages. (2015) J Biol Chem. 290(33):20348-59

  12. Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O'Neill LA, Marelli-Berg FM. The Cellular and Molecular Basis of Translational Immunometabolism. Immunity. 2015 Sep 15;43(3):421-34. doi: 10.1016/j.immuni.2015.08.023. Review.

  13. Kelly B, Tannahill GM, Murphy MP, O'Neill LA. Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages. J Biol Chem. 2015 Aug 14;290(33):20348-59. doi: 10.1074/jbc.M115.662114. Epub 2015 Jul 7.

  14. Netea MG, Latz E, Mills KH, O'Neill LA. Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol. 2015 Jul;16(7):675-9. doi: 10.1038/ni.3178

  15. Mills EL, O'Neill LA. Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal. Eur J Immunol. 2016 Jan;46(1):13-21. doi: 10.1002/eji.201445427.

  16. O'Neill LA. How Low Cholesterol Is Good for Anti-viral Immunity. Cell. 2015 Dec 17;163(7):1572-4. doi: 10.1016/j.cell.2015.12.004.

  17. O'Neill LA, Pearce EJ. Immunometabolism governs dendritic cell and macrophage function. J Exp Med. 2016 Jan 11;213(1):15-23. doi: 10.1084/jem.20151570. Epub 2015 Dec 22. Review.

  18. Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J. Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication. J Immunol. 2016 Mar 15;196(6):2444-9. doi: 10.4049/jimmunol.1501612. Epub 2016 Feb 12.

  19. Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J. A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling. Immunity. 2016 Feb 16;44(2):368-79.

  20. Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ. Trained immunity: A program of innate immune memory in health and disease. Science. 2016 Apr 22;352(6284):aaf1098. doi: 10.1126/science.aaf1098. Epub 2016 Apr 21. Review.

  21. The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.
    Haneklaus M, O'Neil JD, Clark AR, Masters SL, O'Neill LAJ.J Biol Chem. 2017 Apr 28;292(17):6869-6881. doi: 10.1074/jbc.M116.772947. Epub 2017 Mar 16.PMID: 28302726 Free PMC article.

  22. Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.
    Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KHG, O'Neill LA.Front Immunol. 2017 Oct 13;8:1300. doi: 10.3389/fimmu.2017.01300. eCollection 2017.PMID: 29081778 Free PMC article.

  23. The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.
    Zasłona Z, Pålsson-McDermott EM, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran SE, Peters-Golden M, O'Neill LAJ.J Immunol. 2017 May 1;198(9):3558-3564. doi: 10.4049/jimmunol.1602072. Epub 2017 Mar 15.PMID: 28298525 Free article.

  24. An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation.
    Carroll RG, Zasłona Z, Galván-Peña S, Koppe EL, Sévin DC, Angiari S, Triantafilou M, Triantafilou K, Modis LK, O'Neill LA.J Biol Chem. 2018 Apr 13;293(15):5509-5521. doi: 10.1074/jbc.RA118.001921. Epub 2018 Feb 20.PMID: 29463677 Free PMC article.

  25. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
    Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.PMID: 29590092 Free PMC article.

  26. Coupling Krebs cycle metabolites to signalling in immunity and cancer.
    Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.Nat Metab. 2019 Jan;1:16-33. doi: 10.1038/s42255-018-0014-7.PMID: 31032474 Free PMC article.

  27. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
    Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ.Cell Rep. 2019 Oct 1;29(1):151-161.e5. doi: 10.1016/j.celrep.2019.08.072.PMID: 31577945 Free article.

  28. Caspase-11 promotes allergic airway inflammation.
    Zasłona Z, Flis E, Wilk MM, Carroll RG, Palsson-McDermott EM, Hughes MM, Diskin C, Banahan K, Ryan DG, Hooftman A, Misiak A, Kearney J, Lochnit G, Bertrams W, Greulich T, Schmeck B, McElvaney OJ, Mills KHG, Lavelle EC, Wygrecka M, Creagh EM, O'Neill LAJ.Nat Commun. 2020 Feb 26;11(1):1055. doi: 10.1038/s41467-020-14945-2.PMID: 32103022 Free PMC article.

  29. Targeting immunometabolism as an anti-inflammatory strategy.Pålsson-McDermott EM, O'Neill LAJ.Cell Res. 2020 Apr;30(4):300-314. doi: 10.1038/s41422-020-0291-z. Epub 2020 Mar 4.PMID: 32132672 Free PMC article

  30. Krebs Cycle Reborn in Macrophage Immunometabolism.
    Ryan DG, O'Neill LAJ.Annu Rev Immunol. 2020 Apr 26;38:289-313. doi: 10.1146/annurev-immunol-081619-104850. Epub 2020 Jan 27.PMID: 31986069

  31. Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity.
    Angiari S, Runtsch MC, Sutton CE, Palsson-McDermott EM, Kelly B, Rana N, Kane H, Papadopoulou G, Pearce EL, Mills KHG, O'Neill LAJ.Cell Metab. 2020 Feb 4;31(2):391-405.e8. doi: 10.1016/j.cmet.2019.10.015. Epub 2019 Nov 21.PMID: 31761564 Free PMC article.

  32. BCG-induced trained immunity: can it offer protection against COVID-19?
    O'Neill LAJ, Netea MG.Nat Rev Immunol. 2020 Jun;20(6):335-337. doi: 10.1038/s41577-020-0337-y.PMID: 32393823 Free PMC article.

  33. Cytokine-like Roles for Metabolites in Immunity.
    Zasłona Z, O'Neill LAJ.Mol Cell. 2020 Jun 4;78(5):814-823. doi: 10.1016/j.molcel.2020.04.002. Epub 2020 Apr 24.PMID: 32333837 Review.

  34. The Role of HIF in Immunity and Inflammation.
    McGettrick AF, O'Neill LAJ.Cell Metab. 2020 Aug 19:S1550-4131(20)30415-0. doi: 10.1016/j.cmet.2020.08.002. Online ahead of print.PMID: 32853548 Review

  35. The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
    Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ.Cell Metab. 2020 Sep 1;32(3):468-478.e7. doi: 10.1016/j.cmet.2020.07.016. Epub 2020 Aug 12.PMID: 32791101 Free PMC article.