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You are here Research > Groups > Neurodegeneration and CNS Inflammation > Publications

Selected Publications

DHJ Davis, G Muniz Terrera, H Keage, BCM Stephan, J Fleming, PG Ince, FE Matthews, C Cunningham, EW Ely, AMJ MacLullich and C Brayne, (2017) Delirium accelerates cognitive decline in late life: a neuropathological study in 987 individuals from three population-based cohort studies. JAMA Psychiatry (In press).

Edel Hennessy, Shane Gormley, Ana Belen Lopez-Rodriguez, Caoimhe Murray, Carol Murray and Colm Cunningham (2017) Systemic TNF-a produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration. Brain Behavior & Immunity. Jan;59:233-244 (doi:10.1016/j.bbi.2016.09.011)

Varghese, Sreeja, Cotter, Michelle, Chevot, Franciane, Fergus, Claire, Cunningham, Colm, Mills, Kingston, Connon, Stephen, Southern, John, Kelly, Vincent (2016) In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis. Nucleic acids research (In press;

Carroll EC, Jin EL, Mori A, Munoz-Wolf, Oleszycka E, Moran B, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC (2016). The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-Dependent induction of type I Interferons. Immunity 44(3): 597-608 doi 10.1016/j.immunol.2016.02.004

Edel Hennessy, Eadaoin. W. Griffin, Colm Cunningham (2015) Astrocytes are primed by chronic neurodegeneration to produce exaggerated chemokine and cell infiltration responses to acute stimulation with the cytokines IL-1β and TNF-a. Journal of Neuroscience. Jun 3;35(22):8411-22 (DOI:10.1523/JNEUROSCI.2745-14.2015)

Carol Murray, Eadaoin W. Griffin, Elaine O’Loughlin, Aoife Lyons, Eoin Sherwin, Suaad Ahmed, Nigel J Stevenson, Andrew Harkin, Colm Cunningham (2015) Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behavior responses to systemic poly I:C. Brain, Behavior and Immunity. 48:274-86 (doi: 10.1016/j.bbi.2015.04.009)

Renata Reis, Edel Hennessy, Caoimhe Murray, Éadaoin W. Griffin and Colm Cunningham (2015) At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei. Neuropathology and Applied Neurobiology. 41(6):780-797. doi: 10.1111/nan.12232.

Cunningham, C and Hennessy E (2015) Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research. Alzheimer’s Research and Therapy. Mar 7(1): 33. doi 10.1186/s13195-015-0117-2.

Cox DJ, Field, RH, Williams DG, Baran M, Bowie AG, Cunningham C and Dunne A. (2015) DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease. GLIA. May 63(5): 812-825.

Daniel H.J. Davis, Donal T. Skelly, Carol Murray, Edel Hennessy, Jordan Bowen, Samuel Norton, Carol Brayne, Terhi Rahkonen, Raimo Sulkava, David J. Sanderson, J. Nicholas Rawlins, David M. Bannerman, Alasdair M.J. MacLullich and Colm Cunningham (2015) Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. Am J Geriatric Psychiatry. Apr 23(4): 403-415

Eleanor Cape, Roanna J Hall, Barbara C van Munster, Annick de Vries, Sarah EM Howie, Andrew Pearson, Scott D Middleton, Fiona Gillies, Ian R Armstrong, Tim O White, Colm Cunningham, Sophia E de Rooij, Alasdair MJ MacLullich (2014) Cerebrospinal Fluid Markers of Neuroinflammation in Delirium: a role for Interleukin-1β in delirium after hip fracture. J. Psychosom. Res. Sep 77(3): 219-225.

Carol L. Murray, Pauline Obiang, David Bannerman, Colm Cunningham (2013). Endogenous IL-1 in cognitive function and anxiety: A study in IL-1RI-/- mice. PLoS One, Oct 8(10); e78385.

MacLullich, AM, Anand A, Davis DH, Jackson T, Barugh AJ, Hall RJ, Ferguson KJ, Meagher DJ, Cunningham C (2013) New horizons in the pathogenesis, assessment and management of delirium, Age Ageing, Nov; 42(6):667-74.

Éadaoin W. Griffin, Donal T. Skelly, Carol L. Murray, Colm Cunningham (2013) Cyclooxygenase-1 dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction. J. Neurosci, 33(38): 15248-15258

Colm Cunningham (2013). Experimental models of critical illness brain dysfunction. In Brain dysfunction in critical illness. Eds. Ely, Sharshar and Stevens. Cambridge University press, Cambridge, UK.

Skelly DT, Hennessy E, Dansereau MA, Cunningham C. (2013) A systematic analysis of the peripheral and CNS effect of systemic LPS, IL-1 beta, TNF-alpha, and IL-6 in C57BL6 mice. PLoS One, Jul 1;8(7): e69123.

Cunningham C, MacLullich AM. (2013) At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour responses. Brain, Behavior and Immunity, 28: 1-13. doi: 10.1016/j.bbi.2012.07.012.

Cunningham, C (2013) Microglia and neurodegeneration: The role of systemic inflammation. Glia, 61: 71-90. doi: 10.1002/glia.22350.

Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, Maclullich AM, Brayne C (2012) Delirium is a strong risk factor for dementia in the oldest old. Brain, 135(9):2809-16.

Field, Robert H., Gossen, Anna and Cunningham, Colm. (2012) Prior pathology in the basal forebrain cholinergic system predisposes to inflammation induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J. Neurosci. 32(12):6288-6294. doi: 10.1523/JNEUROSCI.4673-11.2012.

Colm Cunningham and Donal T. Skelly (2012) Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium? Journal of Neuroimmune Pharmacology 7(1) 60-73 (doi: 10.1007/s11481-011-9312-5).

Carol L Murray, Donal T Skelly and Colm Cunningham (2011) Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1b and IL-6. Journal of Neuroinflammation. May 17;8:50. (doi:10.1186/1742-2094-8-50).

Alasdair M.J. MacLullich, Benjamin T. Edelshain, Roanna J Hall, Annick de Vries, Sarah E.M. Howie, Andrew Pearson, Scott D Middleton, Fiona Gillies, Ian R Armstrong, Tim O. White, Colm Cunningham, Sophia E.J.A. de Rooij, Barbara C. van Munster, MD, PhD (2011) Cerebrospinal fluid interleukin-8 levels are higher in hip fracture patients with peri-operative delirium versus controls. Journal of the Amercian Geriatric Society 59(6) 1151-1153 (doi: 10.1111/j.1532-5415.2011.03428.x.)

Clive Holmes, Colm Cunningham, Elina Zotova, David Culliford, and Victor Hugh Perry (2011) Pro-inflammatory cytokines, sickness behavior and Alzheimer's disease. Neurology Jul 19;77(3):212-8.

Colm Cunningham (2011) Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem. Soc. Trans. Aug 1;39(4):945-53.

Martina M. Hughes, Robert H. Field, V. Hugh Perry Carol L Murray and Colm Cunningham. (2010) Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation GLIA 58(16) 2017-2030.

DG Diniz; CA Foro; CM Rego,; DA Gloria; FR Rendeiro de Oliveira; JM Papaléo-Paes; AA de Sousa; T Tokuhashi; LS Trindade; MC Pereira Turiel; EG Vasconcelos; JB Torres, C Cunningham; VH Perry, PF Vasconcelos and CW Picanço-Diniz (2010) Environmental impoverishment and aging alter object recognition, spatial learning and dentate gyrus astrocytes. European Journal of Neuroscience 32(3):509-19

Carol Murray, David Sanderson, Chris Barkus, R.M.J. Deacon, J.N.P. Rawlins, David Bannerman and Colm Cunningham. (2012) Systemic inflammation induces acute working memory deficits in the primed brain; relevance for delirium during dementia. Neurobiology of Aging 33(3) 603-616 (doi:10.1016/j.neurobiolaging.2010.04.002)

Robert Field, Suzanne Campion, Colleen Warren, Carol Murray and Colm Cunningham. (2010) Activation of the systemic anti-viral response by poly I:C exacerbates chronic neurodegeneration: microglial priming and amplified IFNb and IL-1b responses Brain Behavior and Immunity 24(6):996-1007. (doi:10.1016/j.bbi.2010.04.004)

J.L. Teeling, C. Cunningham, T.A. Newman and V.H. Perry. (2009) The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1. Brain, Behavior and Immunity 24(3):409-19 (doi:10.1016/j.bbi.2009.11.006)

Clive Holmes, Colm Cunningham, Elina Zotova, Jan Woolford, Christine Dean, Sara Kerr, David Culliford, and Hugh Perry (2009) Systemic inflammation and disease progression in Alzheimer's disease Neurology 73(10):768-74.

Orla Cunningham, Suzanne Campion, Carol Murray, V. Hugh Perry, Nicolai Sidenius, Fabian Docagne and Colm Cunningham. (2009) Microglia and the urokinase plasminogen activator receptor (uPAR) / uPA system in innate brain inflammation. GLIA 57(16):1802-1814.

Cunningham, C., Campion, S., Lunnon, K., Deacon, R.M.J, Rawlins, J.N.P. and Perry, V.H. (2009) Systemic inflammation superimposed on chronic neurodegeneration induces acute behavioural and cognitive changes and accelerates neurological decline. Biological Psychiatry 65(4):304-12.

David J. Sanderson, Colm Cunningham, Robert, M.J. Deacon, David, M. Bannerman, V. Hugh Perry, & J. Nicholas P. Rawlins (2009) A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning. Behavioural Brain Research 201(1):103-111.

Alasdair MacLullich, Sophia de Rooij, Thomas Miller, Karen Ferguson and Colm Cunningham. (2008) Unravelling the pathophysiology of delirium: a focus on aberrant stress responses. Journal of Psychosomatic Research 65; 229-238.

Cunningham, C. and Sanderson, D. (2008) Malaise in the water Maze: untangling the effects of IL-1b and LPS on learning and memory. Brain, Behavior and Immunity 22; 1117-1127.

Ayodeji A Asuni, Colm Cunningham, Piranvhan Vigneswaran, Hugh V Perry and Vincent O'Connor.(2008) Unaltered SNARE complex formation in an in vivo model of Prion disease. Brain Research. 1233; 1-7.

Palin, P., Cunningham, C., Forse, P., V. Hugh Perry and Nick Platt. (2008) Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration. Neurobiology of Disease. 30: 19-29.

Watkins AJ, Wilkins A, Cunningham C, Perry VH, Seet MJ, Osmond C, Eckert JJ, Torrens C, Cagampang FR, Cleal J, Gray WP, Hanson MA, Fleming TP. (2008). Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. Journal of Physiology. 2008 Apr 15; 586(8):2231-44.

Perry, V.H., Cunningham, C. and Holmes, C. (2007) Systemic infections affect chronic neurodegeneration. Nature Reviews Immunology 7(2); 161-167

J.L. Teeling, L.M. Felton, R.M.J. Deacon, C. Cunningham, J.N.P. Rawlins and V.H. Perry (2007) Sub-pyrogenic systemic inflammation impacts of brain and behaviour independent of cytokines. Brain, Behavior and Immunity, 21(6) 836-850.

Colm Cunningham, Suzanne Campion, Jessica Teeling, Leigh Felton and V.H.Perry (2007) The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double stranded RNA (Poly I:C). Brain, Behavior and Immunity, 21(4) 490-502.

Delphine Boche, Colm Cunningham*, Fabian Docagne, Helen Scott and V. Hugh Perry. (2006) TGFb1 regulates the inflammatory response during chronic neurodegeneration. Neurobiology of Disease 22(3): 638-650. *Joint first authorship.

Cunningham, C., Wilcockson D.C., Campion, S., Lunnon K. and Perry, V.H.(2005) Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. Journal of Neuroscience 25(40) 9275-9284.

Felton, L., Cunningham, C. Rankine, E., Waters, S. and V. Hugh Perry. (2005) The role of monocyte chemoattractant protein-1 (MCP-1) in murine prion disease: separation of early behavioural dysfunction from overt clinical disease. Neurobiology of Disease, 20(2) 283-295

Cunningham C., Wilcockson, D.C., Boche, D. and Perry, V.H. (2005) A comparison of brain and peripheral organ cytokine and acute phase protein transcription in the ME7 model of prion disease.  Journal of Virology, 79(8); 5174-5184.

Cunningham, C., Deacon, R.M.J., Chan, K., Boche, D., Rawlins, J.N.P. and Perry, V.H. (2005) Neuropathologically distinct prion disease strains give rise to similar behavioural profiles. Neurobiology of Disease, 18; 258-269.

Picanço-Diniz, C.W., Boche, D., Gomes-Leal, W., Perry, V.H. and Cunningham, C. (2004) Neuropil and Neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease. Neuropathology and Applied Neurobiology 30; 292-303.

Perry V.H., Newman, T.A. Cunningham, C. (2003). The impact of systemic infection on the progression of neurodegenerative disease. Nature Reviews Neuroscience. 4, 103-112.

Boche, D., Cunningham, C., Gauldie, J. and Perry, V.H. (2003) Transforming Growth Factor-b1-mediated Neuroprotection Against Excitotoxic injury in Vivo. Journal of Cerebral Blood Flow and Metabolism. 23:1174-1182.

Cunningham, C., Deacon, R.M.J., Wells, H., Boche, D., Waters, S., Picano Diniz, C., Scott, H., Rawlins, J.N.P. and Perry V.H. (2003) Synaptic changes characterise early behavioural signs in the ME7 model of murine prion disease. European Journal of Neuroscience 17, 2147-2155.

Holmes, C., El-Oki, M., Williams, A.L., Cunningham, C., Wilcockson, D. and Perry, V.H. (2003) Systemic infection, interleukin-1b and cognitive decline in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry 74, 788-789.

Perry, V.H., Cunningham, C. and Boche, D. (2002) Atypical inflammation in the central nervous system in prion disease. Current Opinion in Neurology 15, 349-354.

Combrinck, M.I., Perry, V.H. and Cunningham C. (2002) Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease. Neuroscience. 112, 7-11.

Cunningham, C., Boche, D. and Perry, V.H. (2002) Transforming growth factor b1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix. Neuropathology Applied Neurobiology 28, 107-119.

Colm Cunningham, Keith F. Tipton and Henry B.F. Dixon (1998) Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress. Biochemical Journal 330, 939-945.