Dr. Tomas Ryan
Associate Professor, Biochemistry
Associate Professor, Trinity Inst. of Neurosciences (TCIN)
Publications and Further Research Outputs
Peer-Reviewed Publications
Pignatelli, M. and Ryan, T.J. and Roy, D.S. and Lovett, C. and Smith, L.M. and Muralidhar, S. and Tonegawa, S., Engram Cell Excitability State Determines the Efficacy of Memory Retrieval, Neuron, 101, (2), 2019, p274-284.e5
Ortega-de San Luis, C. and Ryan, T.J., United states of amnesia: rescuing memory loss from diverse conditions, Disease models & mechanisms, 11, (5), 2018
McKay, S. and Ryan, T.J. and McQueen, J. and Indersmitten, T. and Marwick, K.F.M. and Hasel, P. and Kopanitsa, M.V. and Baxter, P.S. and Martel, M.-A. and Kind, P.C. and Wyllie, D.J.A. and O'Dell, T.J. and Grant, S.G.N. and Hardingham, G.E. and Komiyama, N.H., The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences, Cell Reports, 25, (4), 2018, p841-851.e4
De San Luis, C.O. and Ryan, T.J., United States of amnesia: rescuing memory loss from diverse conditions, DMM Disease Models and Mechanisms, 11, (5), 2018
Queenan BN, Ryan TJ, Gazzaniga MS, Gallistel CR, On the research of time past: the hunt for the substrate of memory., Annals of the New York Academy of Sciences, 2017
McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Hardingham GE, Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1., eLife, 2017
Ryan TJ, Tonegawa S., Rehebbilitating Memory., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41, (1), 2016, p370-371
Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S., Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease., Nature, 531, (7595), 2016, p508-512
Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C., What is memory? The present state of the engram., BMC biology, 14, 2016, p40
Frank RA, Komiyama NH, Ryan TJ, Zhu F, O'Dell TJ, Grant SG., NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation., Nature communications, 7, 2016, p11264
Ryan, T.J. and Tonegawa, S., Erratum: Rehebbilitating Memory (Neuropsychopharmacology (2016) 41 (370-371) DOI: 10.1038/npp.2015.264), Neuropsychopharmacology, 41, (5), 2016, p1437
Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S., Memory. Engram cells retain memory under retrograde amnesia., Science (New York, N.Y.), 348, (6238), 2015, p1007-1013
Ryan, T.J. and Roy, D.S. and Pignatelli, M. and Arons, A. and Tonegawa, S., Engram cells retain memory under retrograde amnesia, Science, 348, (6238), 2015, p1007-1013
Tonegawa S, Pignatelli M, Roy DS, Ryan TJ., Memory engram storage and retrieval., Current opinion in neurobiology, 35, 2015, p101-109
Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R.L., Ryan, T.J., Tonegawa, S., Creating a false memory in the hippocampus, 341, (6144), 2013, p387-391
Ryan, T.J. and Kopanitsa, M.V. and Indersmitten, T. and Nithianantharajah, J. and Afinowi, N.O. and Pettit, C. and Stanford, L.E. and Sprengel, R. and Saksida, L.M. and Bussey, T.J. and O'dell, T.J. and Grant, S.G.N. and Komiyama, N.H., Erratum: Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior (Nature Neuroscience (2013) 16 (25-32)), Nature Neuroscience, 16, (12), 2013, p1908
Ryan, T.J., Kopanitsa, M.V., Indersmitten, T., Nithianantharajah, J., Afinowi, N.O., Pettit, C., Stanford, L.E., Sprengel, R., Saksida, L.M., Bussey, T.J., O'Dell, T.J., Grant, S.G.N., Komiyama, N.H., Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior, 16, (1), 2013, p25-32
Martel, M.-A., Ryan, T., Bell, K., Fowler, J., McMahon, A., Al-Mubarak, B., Komiyama, N., Horsburgh, K., Kind, P., Grant, S., Wyllie, D., Hardingham, G., The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults, 74, (3), 2012, p543-556
Ryan, T.J., Grant, S.G.N., The origin and evolution of synapses, 10, (10), 2009, p701-712
Ryan, T.J. and Grant, S.G.N., Erratum: The origin and evolution of synapses (Nature Reviews Neuroscience (2009) 10 (701-712)), Nature Reviews Neuroscience, 10, (11), 2009, p829
Ryan, T.J., Emes, R.D., Grant, S.G.N., Komiyama, N.H., Evolution of NMDA receptor cytoplasmic interaction domains: Implications for organisation of synaptic signalling complexes, 9, 2008
Research Expertise
Recognition
Awards and Honours
European Research Council (ERC) Staring Grant
Science Foundation Ireland - President of Ireland Young Researcher Award (PIYRA)
Jacobs Foundation Research Fellowship
National Health & Medical Research Council (NHMRC) Project Grant
Junior Research Fellowship, Wolfson College, University of Cambridge, UK
Wellcome Trust PhD Studentship (4 years)
Memberships
Society for Neuroscience (USA)