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Dr. Lydia Lynch
Associate Professor in Immunology, Biochemistry

Biography

My lab is interested in understanding the cross-talk between the innate immune system and the metabolic system, and the key molecules involved. A major focus is to understand the cellular metabolic decisions controlling the effector fate of leukocytes that may ultimately open doors to manipulate the immune system in metabolic disorders. This also extends to other situations of altered metabolism, such as in the tumor microenvironment. The goal is to integrate the two aspects of immunometabolism (systemic and intrinsic bioenergetics) to enable us to find metabolic targets for immune cell modulation and ultimately manipulate them in human disease.

Publications and Further Research Outputs

Peer-Reviewed Publications

Kohlgruber A.C, Gal-Oz S.T, LaMarche N.M, Shimazaki M, Duquette D, Koay H.-F, Nguyen H.N, Mina A.I, Paras T, Tavakkoli A, von Andrian U, Uldrich A.P, Godfrey D.I, Banks A.S, Shay T, Brenner M.B, Lynch L, Erratum to: γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis (Nature Immunology, (2018), 19, 5, (464-474), 10.1038/s41590-018-0094-2), Nature Immunology, 20, (3), 2019, p373- Journal Article, 2019 URL DOI

Harmon C, Robinson M.W, Hand F, Almuaili D, Mentor K, Houlihan D.D, Hoti E, Lynch L, Geoghegan J, O'Farrelly C, Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis, Cancer immunology research, 7, (2), 2019, p335 - 346 Journal Article, 2019 DOI URL

Dyck, L. and Lynch, L., Cancer, obesity and immunometabolism â€" Connecting the dots, Cancer Letters, 417, 2018, p11-20 Journal Article, 2018 DOI

Dyck, L. and Lynch, L., New Job for NK Cells: Architects of the Tumor Microenvironment, Immunity, 48, (1), 2018, p9-11 Journal Article, 2018 DOI

Michelet, X. and Dyck, L. and Hogan, A. and Loftus, R.M. and Duquette, D. and Wei, K. and Beyaz, S. and Tavakkoli, A. and Foley, C. and Donnelly, R. and O†Farrelly, C. and Raverdeau, M. and Vernon, A. and Pettee, W. and O†Shea, D. and Nikolajczyk, B.S. and Mills, K.H.G. and Brenner, M.B. and Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nature Immunology, 19, (12), 2018, p1330-1340 Journal Article, 2018 DOI

Wu D, Hu D, Chen H, Shi G, Fetahu I.S, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian C.G, Murphy G.F, Adler G.K, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi Y.G, Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer, Nature, 559, (7715), 2018, p637 - 641 Journal Article, 2018 URL DOI

LaMarche, N.M. and Lynch, L., Adipose Dendritic Cells Come Out of Hiding, Cell Metabolism, 27, (3), 2018, p485-486 Journal Article, 2018 DOI

Kohlgruber, A.C. and Gal-Oz, S.T. and Lamarche, N.M. and Shimazaki, M. and Duquette, D. and Nguyen, H.N. and Mina, A.I. and Paras, T. and Tavakkoli, A. and Von Andrian, U. and Banks, A.S. and Shay, T. and Brenner, M.B. and Lynch, L., γΎ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis /631/250/256 /631/250/2504 article, Nature Immunology, 19, (5), 2018, p464-474 Journal Article, 2018 DOI

Hong, S. and Song, W. and Zushin, P.-J.H. and Liu, B. and Jedrychowski, M.P. and Mina, A.I. and Deng, Z. and Cabarkapa, D. and Hall, J.A. and Palmer, C.J. and Aliakbarian, H. and Szpyt, J. and Gygi, S.P. and Tavakkoli, A. and Lynch, L. and Perrimon, N. and Banks, A.S., Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes, Molecular Metabolism, 12, 2018, p25-38 Journal Article, 2018 DOI TARA - Full Text

Boulenouar, S. and Michelet, X. and Duquette, D. and Alvarez, D. and Hogan, A.E. and Dold, C. and O'Connor, D. and Stutte, S. and Tavakkoli, A. and Winters, D. and Exley, M.A. and O'Shea, D. and Brenner, M.B. and von Andrian, U. and Lynch, L., Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity, Immunity, 46, (2), 2017, p273-286 Journal Article, 2017 DOI

Chang, S.K. and Kohlgruber, A.C. and Mizoguchi, F. and Michelet, X. and Wolf, B.J. and Wei, K. and Lee, P.Y. and Lynch, L. and Duquette, D. and Ceperuelo-Mallafré, V. and Banks, A.S. and Brenner, M.B., Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes, Journal of Clinical Investigation, 127, (9), 2017, p3300-3312 Journal Article, 2017 DOI

Nadine Assmann, Katie L. O'Brien, Raymond P. Donnelly, Lydia Dyck, Vanessa Zaiatz-Bittencourt, Róisín M. Loftus, Paul Heinrich, Peter J. Oefner, Lydia Lynch, Clair M. Gardiner, Katja Dettmer & David K. Finlay, Srebp-controlled glucose metabolism is essential for NK cell functional responses, Nature Immunology, 18, (11), 2017, p1197 - 1206 Journal Article, 2017 DOI URL

PrÃŒss, H. and Tedeschi, A. and Thiriot, A. and Lynch, L. and Loughhead, S.M. and Stutte, S. and Mazo, I.B. and Kopp, M.A. and Brommer, B. and Blex, C. and Geurtz, L.-C. and Liebscher, T. and Niedeggen, A. and Dirnagl, U. and Bradke, F. and Volz, M.S. and DeVivo, M.J. and Chen, Y. and Von Andrian, U.H. and Schwab, J.M., Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex, Nature Neuroscience, 20, (11), 2017, p1549-1559 Journal Article, 2017 DOI

Kohlgruber, A.C. and LaMarche, N.M. and Lynch, L., Adipose tissue at the nexus of systemic and cellular immunometabolism, Seminars in Immunology, 28, (5), 2016, p431-440 Journal Article, 2016 DOI

Lynch, L. and Hogan, A.E. and Duquette, D. and Lester, C. and Banks, A. and LeClair, K. and Cohen, D.E. and Ghosh, A. and Lu, B. and Corrigan, M. and Stevanovic, D. and Maratos-Flier, E. and Drucker, D.J. and O'Shea, D. and Brenner, M., iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy, Cell Metabolism, 24, (3), 2016, p510-519 Journal Article, 2016 TARA - Full Text DOI

Lynch, L. and Michelet, X. and Zhang, S. and Brennan, P.J. and Moseman, A. and Lester, C. and Besra, G. and Vomhof-Dekrey, E.E. and Tighe, M. and Koay, H.-F. and Godfrey, D.I. and Leadbetter, E.A. and Sant'Angelo, D.B. and Von Andrian, U. and Brenner, M.B., Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T reg cells and macrophages in adipose tissue, Nature Immunology, 16, (1), 2015, p85-95 Journal Article, 2015 DOI

Kohlgruber, A. and Lynch, L., Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes, Current Diabetes Reports, 15, (11), 2015 Journal Article, 2015 DOI

Carolan E, Tobin L.M, Mangan B.A, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter D.C, Doherty D.G, Lynch L, O'Shea D, Hogan A.E, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, Journal of Immunology, 194, (12), 2015, p5775 - 5780 Journal Article, 2015 DOI URL

Kim, E.Y. and Lynch, L. and Brennan, P.J. and Cohen, N.R. and Brenner, M.B., The transcriptional programs of iNKT cells, Seminars in Immunology, 27, (1), 2015, p26-32 Journal Article, 2015 DOI

Hogan, A.E. and Gaoatswe, G. and Lynch, L. and Corrigan, M.A. and Woods, C. and O'Connell, J. and O'Shea, D., Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus, Diabetologia, 57, (4), 2014, p781-784 Journal Article, 2014 DOI

Lynch, L., Adipose invariant natural killer T cells, Immunology, 142, (3), 2014, p337-346 Journal Article, 2014 DOI

Tynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, (6), 2014, p2037-2050 Journal Article, 2014 TARA - Full Text DOI

Exley, M.A. and Hand, L. and O'Shea, D. and Lynch, L., Interplay between the immune system and adipose tissue in obesity, Journal of Endocrinology, 223, (2), 2014, pR41-R48 Journal Article, 2014 DOI

Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production., Immunity, 37, (3), 2012, p574-87 Journal Article, 2012 TARA - Full Text DOI

Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J, Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy., American journal of reproductive immunology (New York, N.Y. : 1989), 67, (1), 2012, p9-16 Journal Article, 2012 DOI

Exley, M.A. and Lynch, L. and Nowak, M., NKT cells of cancer patients and how models can inform therapeutic plans, 2012, 129-151pp Book, 2012 DOI

Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D, Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses., Clinical immunology (Orlando, Fla.), 140, (3), 2011, p229-35 Journal Article, 2011

Tobin, A.M., Lynch, L., Kirby, B., O'Farrelly, C., Natural killer cells in psoriasis, Journal of Innate Immunity , 3, (4), 2011, 403-410 Journal Article, 2011 DOI

O'Connell, J. and Lynch, L. and Hogan, A. and Cawood, T.J. and O'Shea, D., Preadipocyte factor-1 is associated with metabolic profile in severe obesity, Journal of Clinical Endocrinology and Metabolism, 96, (4), 2011, pE680-E684 Journal Article, 2011 DOI

Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D, Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis., Diabetologia, 2011 Journal Article, 2011 DOI TARA - Full Text

Exley, M.A. and Lynch, L. and Varghese, B. and Nowak, M. and Alatrakchi, N. and Balk, S.P., Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: Reversing tumor-induced defects, Clinical Immunology, 140, (2), 2011, p184-195 Journal Article, 2011 DOI

O'Connell, J., Lynch, L., Cawood, T.J., Kwasnik, A., Nolan, N., Geoghegan, J., McCormick, A., (...), O'Shea, D., The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity, PLoS ONE , 5, (4), 2010, part. no. e9997 Journal Article, 2010 DOI TARA - Full Text

O'Donovan, A., Hughes, B.M., Slavich, G.M., Lynch, L., Cronin, M.-T., O'Farrelly, C., Malone, K.M, Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships, Brain, Behavior, and Immunity, 24, (7), 2010, p1074-1077 Journal Article, 2010 TARA - Full Text DOI

Nowak, M. and Lynch, L. and Yue, S. and Ohta, A. and Sitkovsky, M. and Balk, S.P. and Exley, M.A., The A2aR adenosine receptor controls cytokine production in iNKT cells, European Journal of Immunology, 40, (3), 2010, p682-687 Journal Article, 2010 DOI

O'Shea, D., Cawood, T.J., O'Farrelly, C., Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke., PloS one, 5, (1), 2010, e8660 Journal Article, 2010 TARA - Full Text DOI

Mcgrath, E., Ryan, E.J., Lynch, L., Golden-Mason, L., Mooney, E., Eogan, M., O'herlihy, C., O'Farrelly, C., Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility, American Journal of Reproductive Immunology, 61, (4), 2009, p265-276 Journal Article, 2009 DOI

Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901 Journal Article, 2009 DOI

Lynch, L.A., O'Connell, J.M., Kwasnik, A.K., Cawood, T.J., O'Farrelly, C., O'Shea, D.B., Are natural killer cells protecting the metabolically healthy obese patient?, Obesity, 17, (3), 2009, p601-605 Journal Article, 2009 DOI

Lynch, L, Golden-Mason, L, Eogan, M, O';Herlihy, C, O'Farrelly, C, Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?, Human reproduction (Oxford, England), 22, (4), 2007, p919-26 Journal Article, 2007 TARA - Full Text DOI URL

Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204 Journal Article, 2006 URL