Professor John O'Leary
Professor Consultant, Histopathology
Professor Consultant, Molecular Medicine Ireland
Publications and Further Research Outputs
Peer-Reviewed Publications
Miles, Mark A. and Huttmann, Thomas D. and Liong, Stella and Liong, Felicia and Oâ Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, Exploring the Contribution of TLR7 to Sex-Based Disparities in Respiratory Syncytial Virus (RSV)-Induced Inflammation and Immunity, Viruses, 17, (3), 2025
Miles, Mark A. and Jayawardena, Sahan and Liong, Stella and Liong, Felicia and Trollope, Gemma S. and Oâ Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, TLR7 deficiency enhances inflammation in the URT but reduces LRT immunity following influenza A infection, Scientific Reports, 15, (1), 2025
LEWIS, F., WARD, M. P., SAADEH, F. A., O'GORMAN, C., MAGUIRE, P. J., BEIRNE, J. P., KAMRAN, W., IBRAHIM, E., NORRIS, L., KELLY, T., HURLEY, S., HENDERSON, B., KANJUGA, M., O'DRISCOLL, L., GATELY, K., ONER, E., SAINI, V. M., CADOO, K., MARTIN, C., O'LEARY, J. J. & O'TOOLE, S. A., A pilot study evaluating the feasibility of enriching and detecting circulating tumour cells from peripheral and ovarian veins in rare epithelial ovarian carcinomas, European Journal of Surgical Oncology, 2025
Hindes MT, McElligott AM, Best OG, Ward MP, Selemidis S, Miles MA, Nturubika BD, Gregory PA, Anderson PH, Logan JM, Butler LM, Waugh DJ, O'Leary JJ, Hickey SM, Thurgood LA, Brooks DA., Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer., Cancer letters, 611, 2025, p217441
Flore, Ornella and Rafii, Shahin and Ely, Scott and O'Leary, John J. and Hyjek, Elizabeth M. and Cesarman, Ethel, Erratum: Editorial Expression of Concern: Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus (Nature), Nature, 643, (8071), 2025, pE13
Tang, Jingying and Lam, Giang T. and Brooks, Robert D. and Miles, Mark and Useckaite, Zivile and Johnson, Ian RD. and Ung, Ben S.-Y. and Martini, Carmela and Karageorgos, Litsa and Hickey, Shane M. and Selemidis, Stavros and Hopkins, Ashley M. and Rowland, Andrew and Vather, Ryash and O'Leary, John J. and Brooks, Douglas A. and Caruso, Maria C. and Logan, Jessica M., Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system, Cancer Letters, 585, 2024
White, Christine and Reynolds, Stephen and Murphy, Katherine and Keegan, Helen and Naik, Padma and O'Brien, Roisin and Pilkington, Loretto and Sharkey Ochoa, Imogen and Glesson, Grainne and Russell, Noirin and Nuttall, David and Tewari, Prerna and Wright, Fiona and O'Toole, Sharon and Sharp, Linda and Flannelly, Grainne and O'Leary, John J. and Martin, Cara M., Performance of the HPV E6/E7 mRNA Aptima HPV assay combined with partial genotyping compared with the HPV DNA Cobas 4800 HPV test for use in primary screening: Results from the CERVIVA HPV primary screening study in Ireland, International Journal of Cancer, 154, (1), 2024, p53 â" 64
Ward MP, Ibrahim EM, O'Toole SA, Marchocki Z, O'Leary JJ, Saadeh FA, Norris LA., Chemotherapy alters thrombomodulin and factor VIIIc expression resulting in acquired activated protein C resistance and enhanced thrombin generation in cancer associated thrombosis., Thrombosis research, 246, 2024, p109251
Giubbi, Chiara and Martinelli, Marianna and Latsuzbaia, Ardashel and Cuschieri, Kate and Elasifer, Hana and Iacobone, Anna Daniela and Bottari, Fabio and Piana, Andrea Fausto and Pietri, Roberto and Tisi, Giancarlo and Odicino, Franco and Arbyn, Marc and Cocuzza, Clementina Elvezia and Perdoni, Federica and Landoni, Fabio and Martella, Silvia and Preti, Eleonora Petra and Guerrieri, Maria Elena and Passerini, Rita and Ghi, Maria Eugenia and Bagella, Maria Paola and Marrazzu, Adriano and Muresu, Narcisa and Sechi, Illari and Dettori, Arianna and Rio, Arcadia Del and Njoku, Ruth Chinyere and Moncur, Sharon and Anthony, Geraldine Breda and McPherson, Sharon and Salinaro, Federica and Gozzini, Elisa and Gargiulo, Franco and Sartori, Enrico and Ferrari, Federico and Caruso, Arnaldo and Caccuri, Francesca and Martin, Cara and Ibrahim, Ola and O'Leary, John, Clinical Performance of OncoPredict HPV Screening Assay on Self-Collected Vaginal and Urine Specimens Within the VALHUDES Framework, Journal of Medical Virology, 96, (11), 2024
Miles, Mark A. and Luong, Raymond and To, Eunice E. and Erlich, Jonathan R. and Liong, Stella and Liong, Felicia and Logan, Jessica M. and Oâ Leary, John and Brooks, Doug A. and Selemidis, Stavros, TLR9 Monotherapy in Immune-Competent Mice Suppresses Orthotopic Prostate Tumor Development, Cells, 13, (1), 2024
M Saini, Volga, Oner, Ezgi, Ward, Mark P., Hurley, Sinead, Henderson, Brian David, Lewis, Faye, Finn, Stephen P., Fitzmaurice, Gerard J., O'Leary, John J., O'Toole, Sharon, O'Driscoll, Lorraine, Gately, Kathy, A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer, Molecular Oncology, 2024
LEWIS, F., BEIRNE, J., HENDERSON, B., NORRIS, L., CADOO, K., KELLY, T., MARTIN, C., HURLEY, S., KANJUGA, M., O'DRISCOLL, L., GATELY, K., ONER, E., SAINI, V. M., BROOKS, D., SELEMIDIS, S., KAMRAN, W., HAUGHEY, N., MAGUIRE, P., O'GORMAN, C., SAADEH, F. A., WARD, M. P., O'LEARY, J. J. & O'TOOLE, S. A., Unravelling the biological and clinical challenges of circulating tumour cells in epithelial ovarian carcinoma, Cancer Letters, 2024
Coward-Smith, Madison and Liong, Stella and Oseghale, Osezua and Erlich, Jonathan R. and Miles, Mark A. and Liong, Felicia and Brassington, Kurt and Bozinovski, Steven and Vlahos, Ross and Brooks, Robert D. and Brooks, Doug A. and Oâ Leary, John J. and Selemidis, Stavros, Low dose aspirin prevents endothelial dysfunction in the aorta and foetal loss in pregnant mice infected with influenza A virus, Frontiers in Immunology, 15, 2024
Ward, Mark P., O'Toole, Sharon A., O'Leary, John J., Potential role of the CD39-CD73 ATP-adenosine pathway in platelet mediated dissemination of circulating tumour cells, British Journal of Cancer, 2024
Nturubika BD, Logan J, Johnson IRD, Moore C, Li KL, Tang J, Lam G, Parkinson-Lawrence E, Williams DB, Chakiris J, Hindes M, Brooks RD, Miles MA, Selemidis S, Gregory P, Weigert R, Butler L, Ward MP, Waugh DJJ, O'Leary JJ, Brooks DA., Components of the Endosome-Lysosome Vesicular Machinery as Drivers of the Metastatic Cascade in Prostate Cancer., Cancers, 17, (1), 2024, p43
Jessica K. Heatlie, Joanna "a"niewska, Courtney R. Moore, I. R. Johnson, Bukuru D. Nturubika, Ruth Williams, Mark P. Ward, John O"Leary, Lisa M. Butler, Doug A. Brooks, Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication, Biomolecules, 15, (1), 2024, p23 - 23, p23-23
Oseghale, Osezua and Quinn, Kylie M. and Coward-Smith, Madison and Liong, Felicia and Miles, Mark A. and Brooks, Robert D. and Vlahos, Ross and Oâ Leary, John J. and Brooks, Doug A. and Liong, Stella and Selemidis, Stavros, Gestational influenza A virus infection elicits nonresolving vascular dysfunction and T-cell accumulation in the aorta of mice, American Journal of Physiology - Heart and Circulatory Physiology, 327, (4), 2024, pH967 â" H977
Martini, Carmela and Logan, Jessica M. and Sorvina, Alexandra and Prabhakaran, Sarita and Ung, Benjamin S Y. and Johnson, Ian R. D. and Hickey, Shane M. and Brooks, Robert D. and Caruso, Maria C. and Klebe, Sonja and Karageorgos, Litsa and Oâ Leary, John J. and Delahunt, Brett and Samaratunga, Hemamali and Brooks, Douglas A, Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer, Virchows Archiv, 485, (4), 2024, p723 â" 728
Logan, Jessica M. and Martini, Carmela and Sorvina, Alexandra and Johnson, Ian R. D. and Brooks, Robert D. and Caruso, Maria C. and Huzzell, Chelsea and Moore, Courtney R. and Karageorgos, Litsa and Butler, Lisa M. and Tewari, Prerna and Prabhakaran, Sarita and Hickey, Shane M. and Klebe, Sonja and Samaratunga, Hemamali and Delahunt, Brett and Moretti, Kim and Oâ Leary, John J. and Brooks, Douglas A. and Ung, Ben S.-Y., Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers, Scientific Data, 11, (1), 2024
BATES, M., MOHAMED, B. M., LEWIS, F., O"TOOLE, S. & O"LEARY, J. J., Biomarkers in high grade serous ovarian cancer, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2024
Miles, Mark A. and Liong, Stella and Liong, Felicia and Trollope, Gemma S. and Wang, Hao and Brooks, Robert D. and Bozinovski, Steven and Oâ Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, TLR7 Promotes Acute Inflammatory-Driven Lung Dysfunction in Influenza-Infected Mice but Prevents Late Airway Hyperresponsiveness, International Journal of Molecular Sciences, 25, (24), 2024
Bates M, Mullen D, Lee E, Costigan D, Heron EA, Kernan N, Barry-OCrowley J, Martin C, Keegan H, Malone, V, Brooks R, Brooks D, Logan, JM, Martini, C, Selemidis S, McFadden J, ORiain C, Spillane CD, Gallagher MF, McCann A, OToole S, OLeary JJ, P53 and TLR4 expression are prognostic markers informing progression free survival of advanced stage high grade serous ovarian cancer, Pathology - Research and Practice, 2024
Nturubika, Bukuru D. and Guardia, Carlos M. and Gershlick, David C. and Logan, Jessica M. and Martini, Carmela and Heatlie, Jessica K. and Lazniewska, Joanna and Moore, Courtney and Lam, Giang T. and Li, Ka L. and Ung, Ben S-Y and Brooks, Robert D. and Hickey, Shane M. and Bert, Andrew G. and Gregory, Philip A. and Butler, Lisa M. and Oâ Leary, John J. and Brooks, Douglas A. and Johnson, Ian R. D., Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression, British Journal of Cancer, 131, (8), 2024, p1263 â" 1278
Lam, Giang T. and Sorvina, Alexandra and Martini, Carmela and Prabhakaran, Sarita and Ung, Ben S.-Y. and Lazniewska, Joanna and Moore, Courtney R. and Beck, Andrew R. and Hopkins, Ashley M. and Johnson, Ian R.D. and Caruso, Maria C. and Hickey, Shane M. and Brooks, Robert D. and Jackett, Louise and Karageorgos, Litsa and Foster-Smith, Erwin J. and Malone, Victoria and Klebe, Sonja and O'Leary, John J. and Brooks, Douglas A. and Logan, Jessica M., Altered endosomal-lysosomal biogenesis in melanoma, Neoplasia (United States), 43, 2023
Lazniewska J, Li KL, Johnson IRD, Sorvina A, Logan JM, Martini C, Moore C, Ung BS, Karageorgos L, Hickey SM, Prabhakaran S, Heatlie JK, Brooks RD, Huzzell C, Warnock NI, Ward MP, Mohammed B, Tewari P, Martin C, O'Toole S, Edgerton LB, Bates M, Moretti P, Pitson SM, Selemidis S, Butler LM, O'Leary JJ, Brooks DA., Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression., Scientific reports, 13, (1), 2023, p13489
Miles, Mark A. and Liong, Stella and Liong, Felicia and Coward-Smith, Madison and Trollope, Gemma S. and Oseghale, Osezua and Erlich, Jonathan R. and Brooks, Robert D. and Logan, Jessica M. and Hickey, Shane and Wang, Hao and Bozinovski, Steven and Oâ Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, TLR7 promotes chronic airway disease in RSV-infected mice, Frontiers in Immunology, 14, 2023
Alharbi B, Qanash H, Binsaleh NK, Alharthi S, Elasbali AM, Gharekhan CH, Mahmoud M, Lioudakis E, O'Leary JJ, Doherty DG, Mohamed BM, Gray SG., Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition, Scientific Reports, 13, 2023, p7462-
Ffrench B, Kashdan E, Huang Y, Spillane CD, Cocchiglia S, Charmsaz S, Varešlija D, O'Brien C, Scholz D, Martin C, Gallagher M, Brooks DA, Brooks RD, Selemidis S, Gleeson N, AbuSaadeh F, O'Riain C, Kamran W, Flavin R, Young L, O'Toole SA, O'Leary JJ., CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity., Heliyon, 9, (1), 2023, pe13044
Sorvina, Alexandra and Martini, Carmela and Prabhakaran, Sarita and Logan, Jessica M. and S-Y. Ung, Benjamin and Moore, Courtney and Johnson, Ian R.D. and Lazniewska, Joanna and Tewari, Prerna and Malone, Victoria and Brooks, Robert D. and Hickey, Shane M. and Caruso, Maria C. and Klebe, Sonja and Karageorgos, Litsa and O'Leary, John J. and Delahunt, Brett and Samaratunga, Hemamali and Brooks, Doug A., Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread, Pathology, 55, (6), 2023, p792 â" 799
Martini, Carmela and Logan, Jessica M. and Sorvina, Alexandra and Prabhakaran, Sarita and Ung, Benjamin S-Y. and Johnson, Ian R. D. and Hickey, Shane M. and Brooks, Robert D. and Caruso, Maria C. and Klebe, Sonja and Karageorgos, Litsa and Oâ Leary, John J. and Delahunt, Brett and Samaratunga, Hemamali and Brooks, Douglas A., Publisher Correction to: Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer (Virchows Archiv, (2023), 10.1007/s00428-023-03643-1), Virchows Archiv, 2023
Bates M, Mohamed BM, Ward MP, Kelly TE, O'Connor R, Malone V, Brooks R, Brooks D, Selemidis S, Martin C, O'Toole S, O'Leary JJ., Circulating tumour cells: The Good, the Bad and the Ugly., Biochim Biophys Acta Rev Cancer, 1878, (2), 2023, p188863
Kelly TE, Spillane CL, Ward MP, Hokamp K, Huang Y, Tewari P, Martin CM, Norris LA, Mohamed BM, Bates M, Brooks R, Selemidis S, Brooks DA, Kamran W, Saadeh FA, O'Toole SA, O'Leary JJ., Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy., Frontiers in cell and developmental biology, 11, 2023, p1150991
Lam, Giang T. and Martini, Carmela and Brooks, Tiffany and Prabhakaran, Sarita and Hopkins, Ashley M. and Ung, Ben S.-Y. and Tang, Jingying and Caruso, Maria C. and Brooks, Robert D. and Johnson, Ian R. D. and Sorvina, Alexandra and Hickey, Shane M. and Karageorgos, Litsa and Klebe, Sonja and Oâ Leary, John J. and Brooks, Douglas A. and Logan, Jessica M., Insights into Melanoma Clinical Practice: A Perspective for Future Research, Cancers, 15, (18), 2023
Mohamed BM, Ward MP, Bates M, Spillane CD, Kelly T, Martin C, Gallagher M, Heffernan S, Norris L, Kennedy J, Saadeh FA, Gleeson N, Brooks DA, Brooks RD, Selemidis S, O'Toole S, O'Leary JJ., Ex vivo expansion of circulating tumour cells (CTCs)., Scientific reports, 13, (1), 2023, p3704 - 3704
Nuttall, David S. and Anderson, Wilma J. and Savage, Amanda J. and Denton, Karin and Martin, Cara M. and Oâ Leary, John J., Calibration of the Becton Dickinson FocalPoint GS slide profiler is essential for optimal performance: Avoiding the algorithm supersaturation cascade effect pitfall, Cancer Cytopathology, 131, (6), 2023, p383 â" 391
Logan JM, Hopkins AM, Martini C, Sorvina A, Tewari P, Prabhakaran S, Huzzell C, Johnson IRD, Hickey SM, Ung BS, Lazniewska J, Brooks RD, Moore CR, Caruso MC, Karageorgos L, Martin CM, O'Toole S, Bogue Edgerton L, Ward MP, Bates M, Selemidis S, Esterman A, Heffernan S, Keegan H, Ní Mhaolcatha S, O'Connor R, Malone V, Carter M, Ryan K, Clarke A, Brady N, Klebe S, Samaratunga H, Delahunt B, Sorich MJ, Moretti K, Butler LM, O'Leary JJ, Brooks DA., Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1., Cancers, 15, (12), 2023, p3215
Sheill G, L Brady, B Hayes, AM Baird, E Guinan, R Vishwakarma, C Brophy, T Vlajnic, O Casey, V Murphy, J Greene, E Allott, J Hussey, F Cahill, M Van Hemelrijck, N Peat, L Mucci, M Cunningham, L Grogan, T Lynch, RP Manecksha, J McCaffrey, D O'Donnell, O Sheils, J O'Leary, S Rudman, R McDermott, S Finn, ExPeCT: a randomised trial examining the impact of exercise on quality of life in men with metastatic prostate cancer, Supportive Care in Cancer, 31, 2023, p292-
O'Donovan B., Mooney T., Rimmer B., Fitzpatrick P., Flannelly G., Doherty L., Russell N., Martin C.M., O'Leary J.J., Sharp L., O'Connor M., Trust and cancer screening: Effects of a screening controversy on women's perceptions of cervical cancer screening, Preventive Medicine Reports, 25, 2022
To, Eunice E. and Erlich, Jonathan R. and Liong, Felicia and Liong, Stella and Luong, Raymond and Oseghale, Osezua and Miles, Mark A. and Papagianis, Paris C. and Quinn, Kylie M. and Bozinovski, Steven and Vlahos, Ross and Brooks, Robert D. and Oâ Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, Therapeutic Targeting of Endosome and Mitochondrial Reactive Oxygen Species Protects Mice From Influenza Virus Morbidity, Frontiers in Pharmacology, 13, 2022
Martini C, Logan JM, Sorvina A, Gordon C, Beck AR, S-Y Ung B, Caruso MC, Moore C, Hocking A, Johnson IRD, Li KL, Karageorgos L, Hopkins AM, Esterman AJ, Huzzell C, Brooks RD, Lazniewska J, Hickey SM, Bader C, Parkinson-Lawrence E, Weigert R, Sorich MJ, Tewari P, Martin C, O'Toole S, Bates M, Ward M, Mohammed B, Keegan H, Watson W, Prendergast S, Heffernan S, NiMhaolcatha S, O'Connor R, Malone V, Carter M, Ryan K, Brady N, Clarke A, Sokol F, Prabhakaran S, Stahl J, Klebe S, Samaratunga H, Delahunt B, Selemidis S, Moretti KL, Butler LM, O'Leary JJ, Brooks DA., Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer., Pathology, 2022, pS0031-3025(22)00226-4
O'Donovan B., Mooney T., Rimmer B., Fitzpatrick P., Flannelly G., Doherty L., Russell N., Martin C.M., O'Leary J.J., Sharp L., O'Connor M., Corrigendum to "Trust and cancer screening: Effects of a screening controversy on women's perceptions of cervical cancer screening" [Prev. Med. Rep. 25 (2022) 101684] (Preventive Medicine Reports (2022) 25, (S2211335521003752), (10.1016/j.pmedr.2021.101684)), Preventive Medicine Reports, 27, 2022
Lazniewska J., Bader C., Hickey S.M., Selemidis S., O'Leary J., Simpson P.V., Stagni S., Plush S.E., Massi M., Brooks D., Rhenium ( I ) conjugates as tools for tracking cholesterol in cells, Metallomics, 14, (8), 2022
Oseghale, Osezua and Vlahos, Ross and Oâ Leary, John J. and Brooks, Robert D. and Brooks, Doug A. and Liong, Stella and Selemidis, Stavros, Influenza Virus Infection during Pregnancy as a Trigger of Acute and Chronic Complications, Viruses, 14, (12), 2022
Traynor D, Duraipandian S, Bhatia R, Cuschieri K, Tewari P, Kearney P, D'Arcy T, O'Leary JJ, Martin CM, Lyng FM., Development and Validation of a Raman Spectroscopic Classification Model for Cervical Intraepithelial Neoplasia (CIN). , Cancers, 14, (7), 2022, p1836
Oseghale O, Liong S, Coward-Smith M, To EE, Erlich JR, Luong R, Liong F, Miles M, Norouzi S, Martin C, O'Toole S, Brooks RD, Bozinovski S, Vlahos R, O'Leary JJ, Brooks DA, Selemidis S., Influenza A virus elicits peri-vascular adipose tissue inflammation and vascular dysfunction of the aorta in pregnant mice., PLoS pathogens, 18, (8), 2022, pe1010703
Sharkey Ochoa I, O'Regan E, Toner M, Kay E, Faul P, O'Keane C, O'Connor R, Mullen D, Nur M, O'Murchu E, Barry-O'Crowley J, Kernan N, Tewari P, Keegan H, O'Toole S, Woods R, Kennedy S, Feeley K, Sharp L, Gheit T, Tommasino M, O'Leary JJ, Martin CM., The Role of HPV in Determining Treatment, Survival, and Prognosis of Head and Neck Squamous Cell Carcinoma., Cancers, 14, (17), 2022, p4321
Hendricks, Keshia S. and To, Eunice E. and Luong, Raymond and Liong, Felicia and Erlich, Jonathan R. and Shah, Ajay M. and Liong, Stella and Oâ Leary, John J. and Brooks, Doug A. and Vlahos, Ross and Selemidis, Stavros, Endothelial NOX4 Oxidase Negatively Regulates Inflammation and Improves Morbidity During Influenza A Virus Lung Infection in Mice, Frontiers in Cellular and Infection Microbiology, 12, 2022
Erlich, Jonathan R. and To, Eunice E. and Luong, Raymond and Liong, Felicia and Liong, Stella and Oseghale, Osezua and Miles, Mark A. and Bozinovski, Steven and Brooks, Robert D. and Vlahos, Ross and Chan, Stanley and Oâ Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages, Antioxidants, 11, (8), 2022
Traynor D, Martin CM, White C, Reynolds S, D'Arcy T, O'Leary JJ, Lyng FM., Raman Spectroscopy of Liquid-Based Cervical Smear Samples as a Triage to Stratify Women Who Are HPV-Positive on Screening., Cancers, 13, (9), 2021
O'Toole SA, Huang Y, Norris L, Power Foley M, Shireen R, McDonald S, Kamran W, Ibrahim N, Ward M, Thompson C, Murphy C, D'Arcy T, Farah N, Heron E, O'Leary JJ, Abu Saadeh F, Gleeson N., HE4 and CA125 as preoperative risk stratifiers for lymph node metastasis in endometrioid carcinoma of the endometrium: A retrospective study in a cohort with histological proof of lymph node status., Gynecologic oncology, 2021
Kate McKendry Stephen Duff Yanmei Huang Mostafa Redha Áine Scanlon Feras Abu Saadeh Noreen Gleeson John O'Leary Lucy Norris Sharon O'Toole, The value of human epididymis 4, D‐dimer, and fibrinogen compared with CA 125 alone in triaging women presenting with pelvic masses: a retrospective cohort study, Acta Obstetricia et Gynecologica Scandinavica, 2021
Tewari P, Kashdan E, Walsh C, Martin CM, Parnell AC, O'Leary JJ., Estimating the conditional probability of developing human papilloma virus related oropharyngeal cancer by combining machine learning and inverse Bayesian modelling., PLoS computational biology, 17, (8), 2021, pe1009289
Di Fiore, Riccardo and Suleiman, Sherif and Felix, Ana and Oâ toole, Sharon A. and Oâ leary, John J. and Ward, Mark P. and Beirne, James and Sabol, Maja and OzretiÄ , Petar and Yordanov, Angel and Vasileva-Slaveva, Mariela and Kostov, Stoyan and Nikolova, Margarita and Said-Huntingford, Ian and Ayers, Duncan and Ellul, Bridget and Pentimalli, Francesca and Giordano, Antonio and Calleja-Agius, Jean, An overview of the role of long non-coding RNAs in human choriocarcinoma, International Journal of Molecular Sciences, 22, (12), 2021
Pisani D, Calleja-Agius J, Di Fiore R, O'Leary JJ, Beirne JP, O'Toole SA, Felix A, Said-Huntingford I., Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab., Current oncology (Toronto, Ont.), 28, (6), 2021, p5346-5355
O'Connor M, McSherry LA, Dombrowski SU, Francis JJ, Martin CM, O'Leary JJ, Sharp L., Identifying ways to maximise cervical screening uptake: a qualitative study of GPs' and practice nurses' cervical cancer screening-related behaviours., HRB Open Res, 4, 2021, p44
Di Fiore, Riccardo and Suleiman, Sherif and Drago-Ferrante, Rosa and Felix, Ana and Oâ toole, Sharon A. and Oâ leary, John J. and Ward, Mark P. and Beirne, James and Yordanov, Angel and Vasileva-Slaveva, Mariela and Subbannayya, Yashwanth and Pentimalli, Francesca and Giordano, Antonio and Calleja-Agius, Jean, Lncrna mort (Znf667-as1) in cancerâ"is there a possible role in gynecological malignancies?, International Journal of Molecular Sciences, 22, (15), 2021
O'Donovan B, Mooney T, Rimmer B, Fitzpatrick P, Flannelly G, Doherty L, Martin C, O'Leary J, O'Connor M, Sharp L., Advancing understanding of influences on cervical screening (non)-participation among younger and older women: A qualitative study using the theoretical domains framework and the COM-B model., Health expectations : an international journal of public participation in health care and health policy, 2021
MacDonagh L, Gallagher MF, Ffrench B, Gasch C, Gray SG, Reidy M, Nicholson S, Leonard N, Ryan R, Young V, O'Leary JJ, Cuffe S, Finn SP, O'Byrne KJ, Barr MP., MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer., Translational lung cancer research, 10, (4), 2021, p1773-1791
Spillane CD, Cooke NM, Ward MP, Kenny D, Blackshields G, Kelly T, Bates M, Huang Y, Martin C, Skehan S, Canney A, Gallagher M, Smyth P, Brady N, Clarke A, Mohamed B, Norris L, Brooks DA, Brooks RD, Heatlie JK, Selemidis S, Hanniffy S, Dixon E, Sheils O, O'Toole SA, O'Leary JJ., The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon., Translational oncology, 14, (12), 2021, p101229
Tewari P, Banka P, Kernan N, Reynolds S, White C, Pilkington L, O'Toole S, Sharp L, D'Arcy T, Murphy C, Comiskey C, Martin CM, O'Leary JJ., Prevalence and concordance of oral HPV infections with cervical HPV infections in women referred to colposcopy with abnormal cytology., Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 50, (7), 2021, p692-699
Ward, Mark P., Saadeh, Feras Abu, O'Toole, Sharon A., O'Leary, John J., Gleeson, Noreen, Norris, Lucy A., Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway, Thrombosis Research, 200, 2021, p91 - 98
Traynor D, Behl I, O'Dea D, Bonnier F, Nicholson S, O'Connell F, Maguire A, Flint S, Galvin S, Healy CM, Martin CM, O'Leary JJ, Malkin A, Byrne HJ, Lyng FM., Raman spectral cytopathology for cancer diagnostic applications., Nature protocols, 16, (7), 2021, p3716-3735
Di Fiore R, Suleiman S, Pentimalli F, O'Toole SA, O'Leary JJ, Ward MP, Conlon NT, Sabol M, Ozreti" P, Erson-Bensan AE, Reed N, Giordano A, Herrington CS, Calleja-Agius J., Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers? A Brief Overview., International journal of molecular sciences, 22, (8), 2021
Oâ Connor, M. and Céilleachair, A.Ã". and Oâ Brien, K. and Oâ Leary, J. and Martin, C. and Dâ Arcy, T. and Flannelly, G. and McRae, J. and Prendiville, W. and Ruttle, C. and White, C. and Pilkington, L. and Sharp, L., Health-related quality of life in women after colposcopy: results from a longitudinal patient survey, Quality of Life Research, 30, (9), 2021, p2509 â" 2520
Hayes B, Brady l, Sheill G, Baird AM, Guinan E, Stanfill B, Dunne J, Holden D, Vlajni T, Casey O, Murphy V, Greene J, Allott WH, Hussey J, Cahill F, Van Hemelrijck M, Peat N, Mucci L, Cunningham M, Grogan L, Lynch T, Manecksha RP, Mc Caffrey J, O'Donnell D, Sheils O, O'Leary J, Rudman S, Mc Dermott R, Finn S, Circulating tumour cell numbers correlate with platelet count and circulating lymphocyte subsets in men with advanced prostate cancer: Data from the ExPeCT clinical trial (CTRIAL-IE 15-21), Cancers, 13, (8), 2021, p4690-
O'Connor, M. and O'Donovan, B. and Waller, J. and Ã" Céilleachair, A. and Gallagher, P. and Martin, C.M. and O'Leary, J. and Sharp, L., Communicating about HPV in the context of head and neck cancer: A systematic review of quantitative studies, Patient Education and Counseling, 103, (3), 2020, p462 â" 472
Kalachand RD, Stordal B, Madden S, Chandler B, Cunningham J, Goode EL, Ruscito I, Braicu EI, Sehouli J, Ignatov A, Yu H, Katsaros D, Mills GB, Lu KH, Carey MS, Timms KM, Kupryjanczyk J, Rzepecka IK, Podgorska A, McAlpine JN, Swisher EM, Bernards SS, O'Riain C, O'Toole S, O'Leary JJ, Bowtell DD, Thomas DM, Prieske K, Joosse SA, Woelber L, Chaudhry P, Häfner N, Runnebaum IB, Hennessy BT., BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis., Journal of the National Cancer Institute, 2020
Bates M, Spillane CD, Gallagher MF, McCann A, Martin C, Blackshields G, Keegan H, Gubbins L, Brooks R, Brooks D, Selemidis S, O'Toole S, O'Leary JJ., The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer., PloS one, 15, (12), 2020, pe0243715
Erlich, Jonathan R. and To, Eunice E. and Liong, Stella and Brooks, Robert and Vlahos, Ross and O'Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, Targeting Evolutionary Conserved Oxidative Stress and Immunometabolic Pathways for the Treatment of Respiratory Infectious Diseases, Antioxidants and Redox Signaling, 32, (13), 2020, p993 â" 1013
Liong S, Oseghale O, To EE, Brassington K, Erlich JR, Luong R, Liong F, Brooks R, Martin C, O'Toole S, Vinh A, O'Neill LAJ, Bozinovski S, Vlahos R, Papagianis PC, O'Leary JJ, Brooks DA, Selemidis S., Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2020
Kalachand RD, O'Riain C, Toomey S, Carr A, Timms KM, O'Toole S, Madden S, Bates M, O'Leary JJ, Gleeson N, O'Donnell D, Grogan L, Breathnach O, Farrelly A, Stordal B, Hennessy BT., Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer., Obstetrics & gynecology science, 63, (5), 2020, p643-654
Ali, Ahlam and Zhang, Fengyu and Maguire, Aaron and Byrne, Tara and Weiner-Gorzel, Karolina and Bridgett, Stephen and Oâ toole, Sharon and Oâ leary, John and Beggan, Caitlin and Fitzpatrick, Patricia and McCann, Amanda and Furlong, Fiona, Hdac6 degradation inhibits the growth of high-grade serous ovarian cancer cells, Cancers, 12, (12), 2020, p1 â" 20
M.O'Connor, J.Waller, P.Gallagher, B.O'Donovan, N.Clarke, I.Keogh, D.MacCarthy, E.O'Sullivan, C.Timon, C.Martin, J.O'Leary, L.Sharp, Barriers and facilitators to discussing HPV with head and neck cancer patients: a qualitative study using the Theoretical Domains Framework, Patient Education and Counseling, 103, (12), 2020, p2451 - 2459
O'Connor M, O'Donovan B, Waller J, Céilleachair AÓ, Gallagher P, Martin C, O'Leary J, Sharp L., The role of healthcare professionals in HPV communication with head and neck cancer patients: A narrative synthesis of qualitative studies., European journal of cancer care, 29, (4), 2020, pe13241
Barr, Martin P. and Gray, Steven G. and Hoffmann, Andreas C. and Hilger, Ralf A. and Thomale, Juergen and Oâ Flaherty, John D. and Fennell, Dean A. and Richard, Derek and Oâ Leary, John J. and Oâ Byrne, Kenneth J., Erratum: Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature (PLoS ONE (2013) 8:1 (e54193) DOI: 10.1371/journal.pone.0054193), PLoS ONE, 15, (5), 2020
To, Eunice E. and Erlich, Jonathan R. and Liong, Felicia and Luong, Raymond and Liong, Stella and Esaq, Farisha and Oseghale, Osezua and Anthony, Desiree and McQualter, Jonathan and Bozinovski, Steven and Vlahos, Ross and O'Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, Mitochondrial Reactive Oxygen Species Contribute to Pathological Inflammation during Influenza A Virus Infection in Mice, Antioxidants and Redox Signaling, 32, (13), 2020, p929 â" 942
Brady L, Hayes B, Sheill G, Baird AM, Guinan E, Stanfill B, Vlajnic T, Casey O, Murphy V, Greene J, Allott EH, Hussey J, Cahill F, Van Hemelrijck M, Peat N, Mucci L, Cunningham M, Grogan L, Lynch T, Manecksha RP, McCaffrey J, O'Donnell D, Sheils O, O'Leary J, Rudman S, McDermott R, Finn S., Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial., PloS one, 15, (12), 2020, pe0243928
Bates Mar, Furlong Fion, Gallagher Michael F, Spillane Cathy D, McCann Amand, O'Toole Sharo, O'Leary John J, Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer, 469, 2020, p11 - 21
To, E.E. and O'Leary, J.J. and O'Neill, L.A.J. and Vlahos, R. and Bozinovski, S. and Porter, C.J.H. and Brooks, R.D. and Brooks, D.A. and Selemidis, S., Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses, Antioxidants and Redox Signaling, 32, (13), 2020, p982-992
Flynn L*, Barr MP*, Baird AM*, Smyth P, Casey OM, Blackshields G, Greene J, Pennington SR, Hams E, Fallon PG, O'Leary JJ, Sheils O, Finn SP. , Prostate cancer-derived holoclones: a novel and effective model for evaluating cancer stemness., Scientific Reports, 10, (1), 2020, p11329-
White, Christine M., Bakhiet, Salih, Bates, Mark, Ruttle, Carmel, Pilkington, Loretto J., Keegan, Helen, O"Toole, Sharon A., Sharp, Linda, O"Kelly, Ruth, Tewari, Prerna, Flannelly, Grainne, Martin, Cara M., O"Leary, John J., Exposure to tobacco smoke measured by urinary nicotine metabolites increases risk of p16/Ki-67 co-expression and high-grade cervical neoplasia in HPV positive women: A two year prospective study, Cancer Epidemiology, 68, 2020, p101793
O'Toole SA, Spillane C, Huang Y, Fitzgerald MC, Ffrench B, Mohamed B, Ward M, Gallagher M, Kelly T, O'Brien C, Ruttle C, Bogdanska A, Martin C, Mullen D, Connolly E, McGarrigle SA, Kennedy J, O'Leary JJ., Circulating tumour cell enumeration does not correlate with Miller-Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy., Breast cancer research and treatment, 181, (3), 2020, p571-580
Cluxton, C.D. and Spillane, C. and Oâ Toole, S.A. and Sheils, O. and Gardiner, C.M. and Oâ Leary, J.J., Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade, PLoS ONE, 14, (3), 2019
Traynor D, Duraipandian S, Bhatia R, Cuschieri K, Martin CM, O'Leary JJ, Lyng FM., The potential of biobanked liquid based cytology samples for cervical cancer screening using Raman spectroscopy. , J of Biophotonics, 2019
Nuttall DS, Hillier S, Clayton HR, Savage AJ, Martin CM, O'Leary JJ. , A retrospective validation of the FocalPoint GS slide profiler NFR technology by analysis of interval disease outcomes compared with manual cytology. , Cancer Cytopathology, 127, (4), 2019, p240 - 246
To, Eunice E. and Erlich, Jonathan and Liong, Felicia and Luong, Raymond and Liong, Stella and Bozinovski, Steven and Seow, Huei Jiunn and Oâ Leary, John J. and Brooks, Doug A. and Vlahos, Ross and Selemidis, Stavros, Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice, Scientific Reports, 9, (1), 2019
Annett Stephani, Moore Gillia, Short Am, Marshall Andre, McCrudden Cia, Yakkundi Anit, Das Sudipt, McCluggage W Glen, Nelson Laur, Harley Ia, Moustafa Nermee, Kennedy Catherine , deFazio Ann, Brand Aliso, Sharma Raghw, Brennan Dona, Oâ Toole Sharo, Oâ Leary Joh, Bates Mar, Oâ Riain Ciará, Oâ Connor Darra, Furlong Fion, McCarthy Hele, Kissenpfennig Adrie, McClements Lan, Robson Trac, FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer, 2019
Jose, B. and Vijayaraghavan, R.K. and Kent, L. and O'Toole, S. and O'Leary, J. and Forster, R.J., Tunable metallic nanostructures using 3D printed nanosphere templates, Electrochemistry Communications, 98, 2019, p106-109
Johnson, Ian R D. and Sorvina, Alexandra and Logan, Jessica M. and Moore, Courtney R. and Heatlie, Jessica K. and Parkinson-Lawrence, Emma J. and Selemidis, Stavros and Oâ leary, John J. and Butler, Lisa M. and Brooks, Douglas A., A paradigm in immunochemistry, revealed by monoclonal antibodies to spatially distinct epitopes on syntenin-1, International Journal of Molecular Sciences, 20, (23), 2019
Clarke, L., Adduri, R.S., Smyth, P., Quinn, F., Jeffers, M., Dunne, B., O'Leary, J., McKiernan, S., Vandenberghe, E., Pyne, S., Bashyam, M.D., Sheils, O., Flavin, R., Potentially important miRNAs in enteropathy-associated T-cell lymphoma pathogenesis: A pilot study, Leukemia Research Reports, 10, 2018, p52-54
Traynor D, Kearney P, Ramos I, Martin CM, O'Leary JJ, Lyng FM., A study of hormonal effects in cervical smear samples using Raman spectroscopy., Journal of biophotonics, 2018, pe201700240-
O'Connor M, O'Leary E, Waller J, Gallagher P, Martin CM, O'Leary JJ, Sharp L, Irish Cervical Screening Research Consortium (CERVIVA)., Socio-economic variations in anticipated adverse reactions to testing HPV positive: Implications for the introduction of primary HPV-based cervical screening., Preventive medicine, 115, 2018, p90-96
Thompson C, Kamran W, Dockrell L, Khalid S, Kumari M, Ibrahim N, OʼLeary J, Norris L, Petzold M, OʼToole S, Gleeson N, The Clearance of Serum Human Epididymis Protein 4 Following Primary Cytoreductive Surgery for Ovarian Carcinoma, International Journal of Gynaecological Cancer, 28, (6), 2018, p1066 - 1072
McSherry LA, O'Leary E, Dombrowski SU, Francis JJ, Martin CM, O'Leary JJ, Sharp L, Which primary care practitioners have poor human papillomavirus (HPV) knowledge? A step towards informing the development of professional education initiatives., Plos One, 13, (12), 2018
Tewari P, White C, Kelly L, Pilkington L, Keegan H, D'Arcy T, Toole SO, Sharp L, O'Leary JJ, Martin CM., Clinical performance of the Cobas 4800 HPV test and the Aptima HPV assay in the management of women referred to colposcopy with minor cytological abnormalities., Diagnostic cytopathology, 46, (12), 2018, p987-992
Duraipandian S, Traynor D, Kearney P, Martin C, O'Leary JJ, Lyng FM., Raman spectroscopic detection of high-grade cervical cytology: Using morphologically normal appearing cells., Scientific reports, 8, (1), 2018, p15048
Harrison, Ian P. and Vinh, Antony and Johnson, Ian R.D. and Luong, Raymond and Drummond, Grant R. and Sobey, Christopher G. and Tiganis, Tony and Williams, Elizabeth D. and O'Leary, John J. and Brooks, Doug A. and Selemidis, Stavros, NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development, Oncotarget, 9, (83), 2018, p35378 â" 35393
Traynor D, Duraipandian S, Martin CM, O'Leary JJ, Lyng FM. , Improved removal of blood contamination from ThinPrep cervical cytology samples for Raman spectroscopic analysis, J Biomed Opt, 23, (5), 2018
Murphy K, Murphy BT, Boyce S, Flynn L, Gilgunn S, O'Rourke CJ, Rooney C, Stöckmann H, Walsh AL, Finn S, O'Kennedy RJ, O'Leary J, Pennington SR, Perry AS, Rudd PM, Saldova R, Sheils O, Shields DC, Watson RW., Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer., Molecular oncology, 2018
O'Connor M, O'Brien K, Waller J, Gallagher P, D'Arcy T, Flannelly G, Martin CM, McRae J, Prendiville W, Ruttle C, White C, Pilkington L, O'Leary JJ, Sharp L, Irish Cervical Screening Research Consortium (CERVIVA)., Physical after-effects of colposcopy and related procedures, and their inter-relationship with psychological distress: a longitudinal survey., BJOG : an international journal of obstetrics and gynaecology, 124, (9), 2017, p1402-1410
Sheill, Gráinne and Brady, Lauren and Guinan, Emer and Hayes, Brian and Casey, Orla and Greene, John and Vlajnic, Tatjana and Cahill, Fidelma and Van Hemelrijck, Mieke and Peat, Nicola and Rudman, Sarah and Hussey, Juliette and Cunningham, Moya and Grogan, Liam and Lynch, Thomas and Manecksha, Rustom P and McCaffrey, John and Mucci, Lorelei and Sheils, Orla and O'Leary, John and O'Donnell, Dearbhaile M and McDermott, Ray and Finn, Stephen, The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial, Trials, 18, (1), 2017, p456
Lynam-Lennon N, Heavey S, Sommerville G, Bibby BA, Ffrench B, Quinn J, Gasch C, O'Leary JJ, Gallagher MF, Reynolds JV, Maher SG, MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype, Oncotarget, 8, (7), 2017, p11400 - 11413
To, E.E. and Vlahos, R. and Luong, R. and Halls, M.L. and Reading, P.C. and King, P.T. and Chan, C. and Drummond, G.R. and Sobey, C.G. and Broughton, B.R.S. and Starkey, M.R. and Van Der Sluis, R. and Lewin, S.R. and Bozinovski, S. and O'Neill, L.A.J. and Quach, T. and Porter, C.J.H. and Brooks, D.A. and O'Leary, J.J. and Selemidis, S., Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy, Nature Communications, 8, (1), 2017
Sulaiman, G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blacksheilds G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee M, Campbell EL, Moynagh P, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ and Gallagher MF. , MyD88 is an essential component of retinoic acid induced differentiation in human pluripotent embryonal carcinoma cells. , Cell Death & Differentiation , 24, (11), 2017, p1975 - 1986
Woods RSR, Keegan H, White C, Tewari P, Toner M, Kennedy S, O'Regan EM, Martin CM, Timon CVI, O'Leary JJ., Cytokeratin 7 in Oropharyngeal Squamous Cell Carcinoma: A Junctional Biomarker for Human Papillomavirus-Related Tumors., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 26, (5), 2017, p702-710
Varga N, Mózes J, Keegan H, White C, Kelly L, Pilkington L, Benczik M, Zsuzsanna S, Sobel G, Koiss R, Babarczi E, Nyíri M, Kovács L, Attila S, Kaltenecker B, Géresi A, Kocsis A, O'Leary J, Martin CM, Jeney C., The Value of a Novel Panel of Cervical Cancer Biomarkers for Triage of HPV Positive Patients and for Detecting Disease Progression., Pathology oncology research : POR, 23, (2), 2017, p295-305
Kearney P, Traynor D, Bonnier F, Lyng FM, O'Leary JJ, Martin CM., Raman spectral signatures of cervical exfoliated cells from liquid-based cytology samples., Journal of biomedical optics, 22, (10), 2017, p1-10
Arts, Florence A and Keogh, Lisa and Smyth, Paul and O'Toole, Sharon and Ta, Robert and Gleeson, Noreen and O'Leary, John J and Flavin, Richard and Sheils, Orla, miR-223 potentially targets SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinoma, Human pathology, 70, 2017, p98 - 104
Ffrench B, Gasch C, Hokamp K, Spillane C, Blackshields G, Mahgoub TM, Bates M, Kehoe L, Mooney A, Doyle R, Doyle B, O'Donnell D, Gleeson N, Hennessy BT, Stordal B, O'Riain C, Lambkin H, O'Toole S, O'Leary JJ, Gallagher MF., CD10(-)/ALDH(-) cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy., Cell Death Disease, 19, (8), 2017, pe3128-
Staunton Lisa, Tonry Claire, Lis Rosina, Espina Virginia, Liotta Lance, Inzitari Rosanna, Bowden Michaela, Fabre Aurelie, O'Leary John, Finn Stephen P, Loda Massimo, Pennington Stephen R, Pathology-Driven Comprehensive Proteomic Profiling of the Prostate Cancer Tumor Microenvironment , Molecular cancer research : MCR , 15 , (3 ), 2017, p281 - 293
MacDonagh Lauren, Gallagher Michael F, Ffrench Brendan, Gasch Claudia, Breen Eamon, Gray Steven G, Nicholson Siobhan, Leonard Niamh, Ryan Ronan, Young Vincent, O'Leary John J, Cuffe Sinead, Finn Stephen P, O'Byrne Kenneth J, Barr Martin P, Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC , Oncotarget , 8 , (42 ), 2017, p72544 - 72563
Ó Céilleachair A, O'Mahony JF, O'Connor M, O'Leary J, Normand C, Martin C, Sharp L., Health-related quality of life as measured by the EQ-5D in the prevention, screening and management of cervical disease: A systematic review., Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 26, (11), 2017, p2885-2897
Gasch, C. and Ffrench, B. and O'Leary, J.J. and Gallagher, M.F., Catching moving targets: Cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention, Molecular Cancer, 16, (1), 2017, p43-
O'Connor M, Gallagher P, Waller J, Martin CM, O'Leary JJ, Sharp L, Irish Cervical Screening Research Consortium (CERVIVA)., Adverse psychological outcomes following colposcopy and related procedures: a systematic review., BJOG : an international journal of obstetrics and gynaecology, 123, (1), 2016, p24-38
O'Connor M, O'Leary E, Waller J, Gallagher P, D'Arcy T, Flannelly G, Martin C.M, McRae J, Prendiville W, Ruttle C, White C, Pilkington L, O'Leary J.J, Sharp L, Trends in, and predictors of, anxiety and specific worries following colposcopy: A 12-month longitudinal study, Psycho-Oncology, 25, (5), 2016, p597 - 604
Aherne, S.T., Smyth, P., Freeley, M., Smith, L., Spillane, C., O'Leary, J., Sheils, O., Altered expression of MIR-222 and MIR-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression, International Journal of Molecular Medicine, 38, (2), 2016, p433-445
Emma R Dorris, Gordon Blackshields, Gary Sommerville, Mohsen Alhashemi, Andrew Dias, Victoria McEneaney, Paul Smyth, John J O'Leary, Orla Sheils, Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines, Cancer biology & therapy, 17, (5), 2016, p526 - 542
Staunton, L., Tonry, C., Lis, R., Finn, S., O'Leary, J., Loda, M., Bowden, M., Pennington, S.R., Profiling the tumor microenvironment proteome in prostate cancer using laser capture microdissection coupled to LC-MS-A technical report, EuPA Open Proteomics, 10, 2016, p19-23
Cooke, N.M., Spillane, C.D., Sheils, O., O'Leary, J., Kenny, D., Aspirin and P2Y
Langhe R, Norris L, Saadeh FA, Blackshields G, Varley R, Harrison A, Gleeson N, Spillane C, Martin C, O'Donnell DM, D'Arcy T, O'Leary J, O'Toole S, A novel serum microRNA panel to discriminate benign from malignant ovarian disease, Cancer Letters, 356, ((2ptB)), 2015, p628-636-
Holl K, Nowakowski A.M, Powell N, McCluggage W.G, Pirog E.C, Collas De Souza S, Tjalma W.A, Rosenlund M, Fiander A, Castro Sánchez M, Damaskou V, Joura E.A, Kirschner B, Koiss R, O'Leary J, Quint W, Reich O, Torné A, Wells M, Rob L, Kolomiets L, Molijn A, Savicheva A, Shipitsyna E, Rosillon D, Jenkins D, Human papillomavirus prevalence and type-distribution in cervical glandular neoplasias: Results from a European multinational epidemiological study, International Journal of Cancer, 137, (12), 2015, p2858 - 2868
O'Connor M, Costello L, Murphy J, Prendiville W, Martin CM, O'Leary JJ, Sharp L, Influences on human papillomavirus (HPV)-related information needs among women having HPV tests for follow-up of abnormal cervical cytology., The journal of family planning and reproductive health care / Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists, 41, (2), 2015, p134-141
Busschots,Steven S., O'Toole,Sharon A. S.A., O'Leary,John James J.J., Stordal,Britta K. B.K., Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines, MethodsX, 2, 2015, p8-13
O'Connor M, Waller J, Gallagher P, Martin C.M, O'Leary J.J, D'Arcy , Prendiville W, Flannelly G, Sharp L, Understanding Women's Differing Experiences of Distress after Colposcopy: A Qualitative Interview Study, Women's Health Issues, 25, (5), 2015, p528 - 534
Langhe R, Norris L, Saadeh FA, Blackshields G, Varley R, Harrison A, Gleeson N, Spillane C, Martin C, O'Donnell DM, D'Arcy T, O'Leary J, O'Toole S, A novel serum microRNA panel to discriminate benign from malignant ovarian disease., Cancer letters, 356, (2 Pt B), 2015, p628-36
Czilwik, G., Messinger, T., Strohmeier, O., Wadle, S., Von Stetten, F., Paust, N., Roth, G., Zengerle, R., Saarinen, P., Niittymäki, J., McAllister, K., Sheils, O., O'Leary, J., Mark, D., Rapid and fully automated bacterial pathogen detection on a centrifugal-microfluidic LabDisk using highly sensitive nested PCR with integrated sample preparation, Lab on a Chip - Miniaturisation for Chemistry and Biology, 15, (18), 2015, p3749-3759
Ffrench, Brendan and O'Leary, John J. and Gallagher, Michael F., Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells, 2015, 639 â" 664pp
O'Mahony JF, Naber SK, Normand C, Sharp L, O'Leary JJ, de Kok IM, Beware of Kinked Frontiers: A Systematic Review of the Choice of Comparator Strategies in Cost-Effectiveness Analyses of Human Papillomavirus Testing in Cervical Screening., Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 18, (8), 2015, p1138-51
Johnson IR, Parkinson-Lawrence EJ, Keegan H, Spillane CD, Barry-O'Crowley J, Watson WR, Selemidis S, Butler LM, O'Leary JJ, Brooks DA, Endosomal gene expression: a new indicator for prostate cancer patient prognosis?, Oncotarget, 6, (35), 2015, p37919-29
Gallagher, M.F., Salley, Y., Spillane, C.D., Ffrench, B., Baruni, S.E., Blacksheilds, G., Smyth, P., Martin, C., Sheils, O., Watson, W., O'Leary, J.J., Enhanced regulation of cell cycle and suppression of osteoblast differentiation molecular signatures by prostate cancer stem-like holoclones, Journal of Clinical Pathology, 68, (9), 2015, p692-702
McEvoy, L.M., O'Toole, S.A., Spillane, C.D., Martin, C.M., Gallagher, M.F., Stordal, B., Blackshields, G., Sheils, O., O'Leary, J.J., Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer, BMC Cancer, 15, (1), 2015, p547-
Glynn M, Kirby D, Nwankire C, Kinahan D, Spillane C, Shiels O, O'Leary J, Ducrée J, Staging the clinical status from blood of cancer patients by chip-based cell enumeration following targetted removal of normal cells, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 2014, 2014, pp461 - 463
d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816-
O'Connor, M. Murphy, J. Martin, C. O'Leary, J. Sharp, L., Motivators for women to attend cervical screening: The influential role of GPs, Family Practice, 31, (4), 2014, p475-482
McRae, J. Martin, C. O'Leary, J. Sharp, L., "If you can't treat HPV, why test for it?" Women's attitudes to the changing face of cervical cancer prevention: A focus group study, BMC Women's Health, 14, (1), 2014, p64-
O'Brien CP, Taylor SE, O'Leary JJ, Finn SP, Molecular testing in oncology: Problems, pitfalls and progress., Lung cancer (Amsterdam, Netherlands), 2014
O'Brien CP, Langabeer SE, O'Byrne KJ, O'Leary JJ, Finn SP, Predictive values for molecular diagnostics: converting unknown unknowns to known unknowns., Molecular diagnosis & therapy, 18, (1), 2014, p1-4
Rashid N, Nawaz H, Poon KW, Bonnier F, Bakhiet S, Martin C, O'Leary JJ, Byrne HJ, Lyng FM, Raman microspectroscopy for the early detection of pre-malignant changes in cervical tissue., Experimental and molecular pathology, 97, (3), 2014, p554-64
Lawlor, D. Martin, P. Busschots, S. Thery, J. O'Leary, J.J. Hennessy, B.T. Stordal, B., PARP inhibitors as p-glyoprotein substrates, Journal of Pharmaceutical Sciences, 103, (6), 2014, p1913 - 1920
Keegan Helen, Pilkington Loretto, McInerney Jamie, Jeney Csaba, Benczik Márta, Cleary Sinead, von Bunau Gunther, Turner Michael, D'Arcy Tom, O' Toole Sharon, Borbála Pal-Szenthe, Borbála Kaltenecker, Johanna Mózes, Anettc Kovács, Agnes Solt, Bolger Noel, O'Leary John, Martin Cara., Human papillomavirus detection and genotyping, by HC2, Full-Spectrum HPV and Molecular Beacon Real-Time HPV assay in an Irish colposcopy clinic, Journal of Virological Methods, 2014
Doherty B, Lawlor D, Gillet JP, Gottesman M, O'Leary JJ, Stordal B, Collateral Sensitivity to Cisplatin in KB-8-5-11 Drug-resistant Cancer Cells., Anticancer research, 34, (1), 2014, p503-7
Sadlier C, Rowley D, Morley D, Surah S, O'Dea S, Delamere S, O'Leary J, Smyth P, Clarke S, Sheils O, Bergin C, Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act., HIV medicine, 15, (8), 2014, p499-504
Kelly LA, Seidlova-Wuttke D, Wuttke W, O'Leary JJ, Norris LA, Estrogen receptor alpha augments changes in hemostatic gene expression in HepG2 cells treated with estradiol and phytoestrogens. , Phytomedicine , 21, (2), 2014, p155 - 158
Vencken SF, Sethupathy P, Blackshields G, Spillane C, Elbaruni S, Sheils O, Gallagher MF, O'Leary JJ, An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines., BMC genomics, 15, 2014, p711
O'Connor M, Costello L, Murphy J, Prendiville W, Martin C.M, O'Leary J.J, Sharp L, 'I don't care whether it's HPV or ABC, i just want to know if i have cancer.' Factors influencing women's emotional responses to undergoing human papillomavirus testing in routine management in cervical screening: A qualitative study, BJOG: An International Journal of Obstetrics and Gynaecology, 121, (11), 2014, p1421 - 1429
Ffrench B, Gasch C, O'Leary JJ, Gallagher MF, Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention., Molecular cancer, 13, 2014, p262
Loy A, McInerney J, Pilkington L, Keegan H, Delamere S, Martin CM, Sheils O, O'Leary JJ, Mulcahy F., Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population., International Journal of Sexually Transmitted Diseases and AIDS, 2014
d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ, The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer., PloS one, 9, (6), 2014, pe100816
Keegan H, Pilkington L, McInerney J, Jeney C, Benczik M, Cleary S, von Bunau G, Turner M, D'Arcy T, O' Toole S, Pal-Szenthe B, Kaltenecker B, Mózes J, Kovács A, Solt A, Bolger N, O'Leary J, Martin C, Human papillomavirus detection and genotyping, by HC2, full-spectrum HPV and molecular beacon real-time HPV assay in an Irish colposcopy clinic., Journal of virological methods, 201, 2014, p93-100
Bonnier,F, Traynor, D, Kearney, P, Clarke,C, Peter Knief, P Martin, C, O'Leary,J, Byrne HJ and Lyng, F, Processing ThinPrep Cervical Cytological Samples for Raman Spectroscopic Analysis., Analytical Methods, 6, (19), 2014, p7831 - 7841
Noninvasive Biomarkers in Ovarian Cancer in, editor(s)Debmalya Barh, Angelo Carpi, Mukesh Verma, Mehmet Gunduz , Cancer Biomarkers: Minimal and Noninvasive Early Diagnosis and Prognosis , CRC press, 2014, [O'Toole, SA, Ancuta, E, Langhe, R, Cahill, DJ, Murphy, M, Martin, C, McEvoy, L, Spillane, C, Sheils, O, Petricoin, E, Liotta, L, O'Leary JJ]
Busschots S, O'Toole S, O'Leary JJ, Stordal B. , Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells, Experimental Cell Research, 2014, p1 - 14
White C, Keegan H, Pilkington L, Ruttle C, Kerr P, Sharp L, O'Toole S, Turner M, Prendiville W, D'Arcy T, Fitzpatrick M, Lenehan P, Flannelly G, O'Leary JJ, Martin CM, Evaluation of the clinical performance of the cobas 4800 HPV test in patients referred for colposcopy., Journal of clinical microbiology, 51, (10), 2013, p3415-7
Stordal B, Timms K, Farrelly A, Gallagher D, Busschots S, Renaud M, Thery J, Williams D, Potter J, Tran T, Korpanty G, Cremona M, Carey M, Li J, Li Y, Aslan O, O'Leary JJ, Mills GB, Hennessy BT., BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation., Molecular Oncology, 7, (3), 2013, p567 - 579
Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103
Abu Saadeh, Norris L, O'Toole S, Mohamed BM, Langhe R, O'Leary J, Gleeson N, Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer- relationship with venous thrombosis risk., Thrombosis Research, 132, 2013, p627 - 634
Tjalma WA, Fiander A, Reich O, Powell N, Nowakowski AM, Kirschner B, Koiss R, O'Leary J, Joura EA, Rosenlund M, Colau B, Schledermann D, Kukk K, Damaskou V, Repanti M, Vladareanu R, Kolomiets L, Savicheva A, Shipitsyna E, Ordi J, Molijn A, Quint W, Raillard A, Rosillon D, De Souza SC, Jenkins D, Holl K, Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe., International journal of cancer. Journal international du cancer, 132, (4), 2013, p854-67
Brosnan JF, Sheppard BL, Kelly LA, O'Leary JJ, Norris LA, Norethisterone acetate alters coagulation gene expression in vitro in human cell culture., Thrombosis research, 131, (1), 2013, p72 - 77
Cooke, Niamh M. and Egan, Karl and Mcfadden, Siobhan and Grogan, Liam and Breathnach, Oscar S. and O'Leary, John and Hennessy, Bryan T. and Kenny, Dermot, Increased platelet reactivity in patients with late-stage metastatic cancer, Cancer Medicine, 2, (4), 2013, p564 â" 570
Barr MP, Gray SG, Hoffmann AC, Hilger RA, Thomale J, O'Flaherty JD, Fennell DA, Richard D, O'Leary JJ, O'Byrne KJ., Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature., PloS one, 8, (1), 2013, pe54193
Abu Saadeh F, Norris L, O'Toole S, Langhe R, O'Leary JJ, Gleeson N., Does tissue factor and tissue factor pathway inhibitor over-expression play a role in the development of venous thromboembolism in ovarian cancer patients?, Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, ((Suppl 1)), Elsevier, 2012, pp170-
Abu Saadeh F, Norris L, O'Toole S, Langhe R, Gleeson N., Procoagulant activity in patients with gynecological malignancies and the effect of neoadjuvant chemotherapy , Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, (Suppl 1), Elsevier, 2012
Murphy MA, O'Connell DJ, O'Kane SL, O'Brien JK, O'Toole S, Martin C, Sheils O, O'Leary JJ, Cahill DJ, Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays, Journal of Proteomics, 75, (15), 2012, p4668 - 4675
McSherry LA, Dombrowski SU, Francis JJ, Murphy J, Martin CM, O'Leary JJ, Sharp L, Group A, 'It's a can of worms': understanding primary care practitioners' behaviours in relation to HPV using the theoretical domains framework., Implementation science : IS, 7, (1), 2012, p73
O'Flaherty JD, Gray S, Richard D, Fennell D, O'Leary JJ, Blackhall FH, O'Byrne KJ, Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer., Lung cancer (Amsterdam, Netherlands), 76, (1), 2012, p19-25
Logan C, Habington A, Lennon G, Grogan J, Byrne M, O'Leary J, O'Sullivan N, Genetic relatedness of Pseudomonas aeruginosa isolates among a paediatric cystic fibrosis patient cohort in Ireland., Journal of medical microbiology, 61, (Pt 1), 2012, p64-70
McSherry, Lisa A. and Dombrowski, Stephan U. and Francis, Jill J. and Murphy, Judith and Martin, Cara M. and O'Leary, John J. and Sharp, Linda, 'It's a can of worms': Understanding primary care practitioners' behaviours in relation to HPV using the theoretical domains framework, Implementation Science, 7, (1), 2012
Flavin R, Finn SP, Choueiri TK, Ingoldsby H, Ring M, Barrett C, Rogers M, Smyth P, O'Regan E, Gaffney E, O'Leary JJ, Loda M, Signoretti S, Sheils O, RET protein expression in papillary renal cell carcinoma., Urologic oncology, 30, (6), 2012, p900-5
Abu Saadeh. F, Norris. L, O' Toole. S, Langhe. R, O' Leary. J, Gleeson. N. , Why is venous thromboembolism is a common complication of ovarian cancer? , International Journal of Gynecological Cancer , 14th Biennial Meeting of the International Gynecological Cancer Society. , Vancouver, Canada, October 2012, 22, (Suppl 3), 2012, ppE247-
Gulliksen A, Keegan H, Martin C, O'Leary J, Solli LA, Falang IM, Grønn P, Karlgård A, Mielnik MM, Johansen IR, Tofteberg TR, Baier T, Gransee R, Drese K, Hansen-Hagge T, Riegger L, Koltay P, Zengerle R, Karlsen F, Ausen D, Furuberg L, Towards a "Sample-In, Answer-Out" Point-of-Care Platform for Nucleic Acid Extraction and Amplification: Using an HPV E6/E7 mRNA Model System., Journal of oncology, 2012, 2012, p905024
Stordal, B., Hamon, M., McEneaney, V., Roche, S., Gillet, J-P., O'Leary, J.J, Gottesman, M. and Clynes, M., Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein, PLoS One, 7, (7), 2012, pe40717-
Kirby, D., Siegrist, J., Kijanka, G., Zavattoni, L., Sheils, O., O'Leary, J., Burger, R., Ducrée, J., Centrifugo-magnetophoretic particle separation, Microfluidics and Nanofluidics, 13, (6), 2012, p899-908
Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012
Furlong F, Fitzpatrick P, O'Toole S, Phelan S, McGrogan B, Maguire A, O'Grady A, Gallagher M, Prencipe M, McGoldrick A, McGettigan P, Brennan D, Sheils O, Martin C, W Kay E, O'Leary J, McCann A, Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer., The Journal of pathology, 226, (5), 2012, p746-55
O'Flaherty JD, Barr M, Fennell D, Richard D, Reynolds J, O'Leary J, O'Byrne K, The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 7, (12), 2012, p1880-90
Abu Saadeh. F, Norris. L, O' Toole. S, Langhe. R, Gleeson. N, Endogenous thrombin potential as a marker for venous thrombosis in ovarian cancer., International Journal of Gynecological Cancer , 14th Biennial Meeting of the International Gynecological Cancer Society., Vancouver, Canada, October 2012, 22, (Suppl 3), 2012, ppE248-
Dorris ER, Smyth P, O'Leary JJ, Sheils O, MIR141 Expression Differentiates Hashimoto Thyroiditis from PTC and Benign Thyrocytes in Irish Archival Thyroid Tissues., Frontiers in endocrinology, 3, 2012, p102
Murphy MA, O'Leary JJ, Cahill DJ, Assessment of the humoral immune response to cancer., Journal of proteomics, 75, (15), 2012, p4573-9
Gallagher MF, Heffron CC, Laios A, O'Toole SA, Ffrench B, Smyth PC, Flavin RJ, Elbaruni SA, Spillane CD, Martin CM, Sheils OM, O'Leary JJ, Suppression of cancer stemness p21-regulating mRNA and microRNA signatures in recurrent ovarian cancer patient samples., Journal of ovarian research, 5, (1), 2012, p2
Martin CM, O'Leary JJ, Histology of cervical intraepithelial neoplasia and the role of biomarkers., Best practice & research. Clinical obstetrics & gynaecology, 25, (5), 2011, p605-15
Oon SF, Watson RW, O'Leary JJ, Fitzpatrick JM, Epstein criteria for insignificant prostate cancer., BJU international, 2011
Astbury K, McEvoy L, Brian H, Spillane C, Sheils O, Martin C, O'Leary JJ, MYBL2 (B-MYB) in cervical cancer: putative biomarker., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 21, (2), 2011, p206-12
O'Hurley G, Perry AS, O'Grady A, Loftus B, Smyth P, O'Leary JJ, Sheils O, Fitzpatrick JM, Hewitt SM, Lawler M, Kay EW, The role of secreted frizzled-related protein 2 expression in prostate cancer., Histopathology, 59, (6), 2011, p1240-1248
Ostrowska KM, Garcia A, Meade AD, Malkin A, Okewumi I, O'Leary JJ, Martin C, Byrne HJ, Lyng FM, Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells., The Analyst, 136, (7), 2011, p1365-73
Egan K, Crowley D, Smyth P, O'Toole S, Spillane C, Martin C, Gallagher M, Canney A, Norris L, Conlon N, McEvoy L, Ffrench B, Stordal B, Keegan H, Finn S, McEneaney V, Laios A, Ducrée J, Dunne E, Smith L, Berndt M, Sheils O, Kenny D, O'Leary J, Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells., PloS one, 6, (10), 2011, pe26125
Egan K, Crowley D, Smyth P, O'Toole S, Spillane C, Martin C, Gallagher M, Canney A, Norris L, Conlon N, McEvoy L, Ffrench B, Stordal B, Keegan H, Finn S, McEneaney V, Laios A, Ducrée J, Dunne E, Smith L, Berndt M, Sheils O, Kenny D, O'Leary J, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLoS ONE, 6, (10, e26125), 2011
Grogan JA, Logan C, O'Leary J, Rush R, O'Sullivan N, Real-time PCR-based detection of Bordetella pertussis and Bordetella parapertussis in an Irish paediatric population., Journal of medical microbiology, 60, (Pt 6), 2011, p722-9
Yusof A, Keegan H, Spillane CD, Sheils OM, Martin CM, O'Leary JJ, Zengerle R, Koltay P, Inkjet-like printing of single-cells., Lab on a chip, 11, (14), 2011, p2447-54
Cantwell-Dorris ER, O'Leary JJ, Sheils OM, BRAFV600E: implications for carcinogenesis and molecular therapy., Molecular cancer therapeutics, 10, (3), 2011, p385-94
Ostrowska KM, Malkin A, Meade A, O'Leary J, Martin C, Spillane C, Byrne HJ, Lyng FM., Investigation of the influence of high-risk human papillomavirus on the biochemical composition of cervical cancer cells using vibrational spectroscopy., Analyst., (Oct 21), 2010
Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nature Immunology, 11, (2), 2010, p141-147
Wakefield, A.J. and Anthony, A. and Murch, S.H. and Thomson, M. and Montgomery, S.M. and Davies, S. and O'Leary, J.J. and Berelowitz, M. and Walker-Smith, J.A., Erratum: Enterocolitis in children with developmental disorders (American Journal of Gastroenterol (2000) 95 (2285-2295)), American Journal of Gastroenterology, 105, (5), 2010, p1214
Mocanu E, Shattock R, Barton D, Rogers M, Conroy R, Sheils O, Collins C, Martin C, Harrison R, O'Leary J, All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection., Fertility and sterility, 2010
Kelly JG, Cheung KT, Martin C, O'Leary JJ, Prendiville W, Martin-Hirsch PL, Martin FL, A spectral phenotype of oncogenic human papillomavirus-infected exfoliative cervical cytology distinguishes women based on age., Clinica chimica acta; international journal of clinical chemistry, 411, (15-16), 2010, p1027-1033
O'Hurley G, O'Grady A, Smyth P, Byrne J, O'Leary JJ, Sheils O, Watson RW, Kay EW, Evaluation of Zinc-alpha-2-Glycoprotein and Proteasome Subunit beta-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, 2010
Kelly LA, O'Leary JJ, Seidlova-Wuttke D, Wuttke W, Norris LA, Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens, Thrombosis and Haemostasis, 104, (6), 2010, p1083-1289
Baier T, Hansen-Hagge TE, Gransee R, Crombé A, Schmahl S, Paulus C, Drese KS, Keegan H, Martin C, O'Leary JJ, Furuberg L, Solli L, Grønn P, Falang IM, Karlgård A, Gulliksen A, Karlsen F, Hands-free sample preparation platform for nucleic acid analysis., Lab on a chip, 9, (23), 2009, p3399-405
Flavin, R., Smyth, P., Barrett, C., Russell, S., Wen, H., Wei, J., Laios, A., O'Toole, S., Ring, M., Denning, K., Li, J., Aherne, S., Sammarae, D., Aziz, N.A., Alhadi, A., Finn, S.P., Loda, M., Sheppard, B., Sheils, O., O'Leary, J.J., MiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma, International Journal of Gynecological Cancer, 19, (4), 2009, p641-647
Flavin, R.J., Smyth, P.C., Laios, A., O'Toole, S.A., Barrett, C., Finn, S.P., Russell, S., (...), O'Leary, J.J. , Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma, Modern Pathology , 22, (2), 2009, p197-205
Keegan, H., Mc Inerney, J., Pilkington, L., Grønn, P., Silva, I., Karlsen, F., Bolger, N., (...), Martin, C. , Comparison of HPV detection technologies: Hybrid capture 2, PreTect HPV-Proofer and analysis of HPV DNA viral load in HPV16, HPV18 and HPV33 E6/E7 mRNA positive specimens, Journal of Virological Methods , 155, (1), 2009, p61-66
Flavin R, Smyth P, Barrett C, Russell S, Wen H, Wei J, Laios A, O'Toole S, Ring M, Denning K, Li J, Aherne S, Sammarae D, Aziz NA, Alhadi A, Finn SP, Loda M, B S, Sheils O, O'Leary JJ, miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19, (4), 2009, p641-7
Flavin R, Jackl G, Finn S, Smyth P, Ring M, O'Regan E, Cahill S, Unger K, Denning K, Jinghuan Li Aherne S, Tallini G, Gaffney E, O'Leary JJ, Zitzelsberger H, Sheils O, RET/PTC rearrangement occurring in primary peritoneal carcinoma., International journal of surgical pathology, 17, (3), 2009, p187-97
Martin, C.M., Astbury, K., McEvoy, L., O'Toole, S., Sheils, O., O'Leary, J.J., Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy., Methods in molecular biology (Clifton, N.J.), 511, 2009, p333-359
Gallagher MF, Flavin RJ, Elbaruni SA, McInerney JK, Smyth PC, Salley YM, Vencken SF, O'Toole SA, Laios A, Lee MY, Denning K, Li J, Aherne ST, Lao KQ, Martin CM, Sheils OM, O'Leary JJ, Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients., Journal of ovarian research, 2, 2009, p19
Field JK, Liloglou T, Niaz A, Bryan J, Gosney JR, Giles T, Brambilla C, Brambilla E, Vesin A, Timsit JF, Hainaut P, Martinet Y, Vignaud JM, Thunnissen FB, Prinsen C, Snijders PJ, Smit EF, Sozzi G, Roz L, Risch A, Becker HD, Elborn JS, Magee ND, Montuenga LM, Pajares MJ, Lozano MD, O'Byrne KJ, Harrison DJ, Niklinski J, Cassidy A, EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration., The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, 34, (6), 2009, p1477-86
O'Regan, E.M., Toner, M.E., Finn, S.P., Fan, C.Y., Ring, M., Hagmar, B., Timon, C., Smyth, P., Cahill, S., Flavin, R., Sheils, O.M., O'Leary, J.J., p16INK4A genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas, Human Pathology, 39, (3), 2008, p452-458
Li J, Smyth P, Cahill S, Denning K, Flavin R, Aherne S, Pirotta M, Guenther SM, O'Leary JJ, Sheils O, Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials., BMC biotechnology, 8, 2008, p10
Denning K, Smyth P, Cahill S, Li J, Flavin R, Aherne S, O' Leary JJ, Sheils O, ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells., Molecular cancer, 7, 2008, p44
Flavin RJ, Smyth PC, Finn SP, Laios A, O'Toole SA, Barrett C, Ring M, Denning KM, Li J, Aherne ST, Aziz NA, Alhadi A, Sheppard BL, Loda M, Martin C, Sheils OM, O'Leary JJ., Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients., Modern Pathology, 21, (6), 2008, p676 - 684
Laios, A., O'Toole, S.A., Flavin, R., Martin, C., Ring, M., Gleeson, N., D'Arcy, T., (...), O' Leary, J.J. , An integrative model for recurrence in ovarian cancer , Molecular Cancer, 7, 2008
Aherne ST, Smyth PC, Flavin RJ, Russell SM, Denning KM, Li JH, Guenther SM, O'Leary JJ, Sheils OM., Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling., Molecular Cancer, 7, 2008, particle no, 89
Hornig, M., Briese, T., Buie, T., Bauman, M.L., Lauwers, G., Siemetzki, U., Hummel, K., (...), Lipkin, W.I. , Lack of association between measles virus vaccine and autism with enteropathy: A case-control study , PLoS ONE, 3, (9), 2008, part. no. e3140
Laios, A., O'Toole, S., Flavin, R., Martin, C., Kelly, L., Ring, M., Finn, S.P., (...), O'Leary, J. , Potential role of miR-9 and miR-223 in recurrent ovarian cancer , Molecular Cancer, 7, 2008, part. no. 35
Murphy AJ, Hughes CA, Barrett C, Magee H, Loftus B, O'Leary JJ, Sheils O, Low Level TOP2A Amplification in Prostate Cancer is associated with HER2 Duplication, Androgen Resistance and Decreased Survival, Cancer Research , 67, (6), 2007, p2893 - 2898
Crowley A, Martin C, Fitzpatrick P, Sheils O, O'Herlihy C, O'Leary JJ, Byrne BM, Free fetal DNA is not increased before 20 weeks in intrauterine growth, Prenat Diagn., 27, (2), 2007, p174 - 179
R. Flavin, P.Symth, S. Finn, P. Crotty, M Ring, S Cahill, E.M. O'Regan,, BRAF T1799A mutation occurring in a case of malignant struma ovarii, Int J Surg Pathology, 2007
Murphy AJ, Hughes CA, Lannigan G, Sheils O, O'Leary J, Loftus B, Heterogeneous expression of alpha-methylacyl-CoA racemase in prostatic cancer correlates with Gleason score, Histopathology, 50, (2), 2007, p243 - 251
Denning KM, Smyth PC, Cahill SF, Finn SP, Conlon E, Li J, Flavin RJ, Aherne ST, Guenther SM, Ferlinz A, O'Leary JJ, Sheils OM, A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20, (10), 2007, p1095-102
Logan, C., O'Leary, J.J., O'Sullivan, N. , Real-time reverse transcription PCR detection of norovirus, sapovirus and astrovirus as causative agents of acute viral gastroenteritis , Journal of Virological Methods, 146, (1-2), 2007, p36-44
Li J, Smyth P, Flavin R, Cahill S, Denning K, Aherne S, Guenther SM, O'Leary JJ, Sheils O, Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells., BMC biotechnology, 7, 2007, p36
Cahill S, Smyth P, Denning K, Flavin R, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ, Sheils O, Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model., Molecular cancer, 6, 2007, p21
Finn SP, Smyth P, Cahill S, Streck C, O'regan EM, Flavin R, Sherlock J,Howells D, Henfrey R, Cullen M, Toner M, Timon C, O'leary JJ, Sheils OM, Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy, Virchows Arch, 450, (3), 2007, p249 - 260
Martin CM, Kehoe L, Spillane CO, O'Leary JJ., Gene discovery in cervical cancer : towards diagnostic and therapeutic biomarkers., Molecular Diagnosis and Therapy , 11, (5), 2007, p277-90
Heffron, C.C.B.B., Gallagher, M.F., Guenther, S., Sherlock, J., Henfrey, R., Martin, C., Sheils, O., O'Leary, J.J. , Global mRNA analysis to determine a transcriptome profile of cancer stemness in a mouse model , Anticancer Research, 27, (3A), 2007, p1319-1324
O'Toole SA, Sheppard BL, Laios A, O'Leary JJ, McGuinness EP, D'Arcy T,Bonnar J, Potential predictors of chemotherapy response in ovarian cancer--how do we define chemosensitivity?, Gynecol Oncol., 104, (2), 2007, p345 - 351
Finn S, Smyth P, O'Regan E, Cahill S, Toner M, Timon C, Flavin R, O'Leary J,Sheils O, Low-level genomic instability is a feature of papillary thyroid carcinoma: an array comparative genomic hybridization study of laser capture microdissected papillary thyroid carcinoma tumors and clonal cell lines, Arch Pathol Lab Med., 13, (1), 2007, p65 - 73
Crowley, A., Martin, C., Fitzpatrick, P., Sheils, O., O'Herlihy, C., O'Leary, J.J., Byrne, B.M., Free fetal DNA is not increased before 20 weeks in intrauterine growth restriction or pre-eclampsia, Prenatal Diagnosis, 27, (2), 2007, p174-179
Furuberg, L., Mielnik, M., Johansen, I.-R., Voitel, J., Gulliksen, A., Solli, L., Karlsen, F., (...), Koltay, P. , The micro active project: Automatic detection of disease-related molecular cell activity , Proceedings of SPIE - The International Society for Optical Engineering, 6589, 2007, part. no. 65891B
Murphy, A.J., Hughes, C.A., Barrett, C., Magee, H., Loftus, B., O'Leary, J.J., Sheils, O., Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival, Cancer Research, 67, (6), 2007, p2893-2898
Logan C, O'Leary JJ, O'Sullivan N, Real-time reverse transcription-PCR for detection of rotavirus and adenovirus as causative agents of acute viral gastroenteritis in children, J Clin Microbiol., 44, (9), 2006, p3189 - 3195
Bolger, N., Heffron, C., Regan, I., Sweeney, M., Kinsella, S., McKeown, M., Creighton, G., (...), O'Leary, J. , Cervical cytology: Implementation and evaluation of a new automated interactive image analysis system , Acta Cytologica, 50 - (5), 2006, p483-491
O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ, Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays, International Journal of Gynecological Cancer , 16, (2), 2006, p834 - 842
Bolger N, Heffron C, Regan I, Sweeney M, Kinsella S, McKeown M, Creighton G,Russell J, O'Leary J, Implementation and evaluation of a new automated interactive image analysis system, Acta Cytol., 50, (5), 2006, p483 - 491
Leahy M, Farah N, Bolger N, O'Leary JJ, Turner MJ, Should cervical smears be taken at a postnatal visit?, Irish Medical Journal, 99, (8), 2006, p244 - 245
O'Regan EM, Toner ME, Smyth PC, Finn SP, Timon C, Cahill S, Flavin R, O'Leary JJ, Sheils O, Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients., Head & neck, 28, (4), 2006, p330-8
Cahill S, Smyth P, Finn SP, Denning K, Flavin R, O'Regan EM, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ, Sheils O, Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model., Molecular cancer, 5, 2006, p70
Martin CM, Astbury K, O'Leary JJ, Molecular profiling of cervical neoplasia, Expert Review of Molecular Diagnostics , 6, (2), 2006, p217 - 229
Hughes C, Murphy A, Martin C, Fox E, Ring M, Sheils O, Loftus B, O'Leary J, Topoisomerase II-alpha expression increases with increasing Gleason score and with hormone insensitivity in prostate carcinoma, Journal of Clinical Pathology, 59, (7), 2006, p721 - 724
Pathology 2026: The future of laboratory medicine and academic pathology in, editor(s)John Wiley & Sons , Understanding disease, John Wiley & Sons, 2006, pp217 - 231, [O'Leary JJ]
Astbury, K., Martin, C.M., Ring, M., Pilkington, L., Bolger, N., Sheils, O.M., O'Leary, J.J. , Future molecular aspects of cervical cytology , Current Diagnostic Pathology, 12, (2), 2006, p104-113
O'Regan EM, Timon C, Sheils O, Codd M, O'Leary JJ, Toner M, Squamous cell carcinoma of the head and neck in young Irish adults, British Journal of Oral and Maxillofacial Surgery , 44, (3), 2006, p203 - 206
Tumour markers in cervical cancer in, editor(s)Jordan JA, Singer A , The Cervix, Blackwell Publishing, 2006, pp399 - 413, [O'Leary JJ, Astbury K, Prendiville W]
CGH array analysis of human tissues in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp523 - 528, [O'Regan, E, Martin, C.M., Finn, S, Smyth, P., Flavin, R., O'Leary, J.J. Sheils, O.]
O'Toole SA, Sheppard BL, Sheils O, O'Leary JJ, Spengler B, Christoffel V, Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays, Planta Medica, 71, (5), 2005, p435 - 439
Murphy, N., Ring, M., Heffron, C.C.B.B., Martin, C.M., McGuinness, E., Sheils, O., O'Leary, J.J., Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix, Modern Pathology , 18, (6), 2005, p844-849
Laser capture microdissection in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp489 - 493, [Sheils, O., Smyth, P., O'Regan, E.M.,Finn, S., Flavin, R., O'Leary, J.J.]
O'Toole SA, Dunn E, Sheppard BL, Sheils O, O'Leary JJ, Wuttke W,, Oestrogen regulated gene expression in normal and malignant endometrial tissue, Maturitas, 51, (2), 2005, p187 - 198
Mocanu EV, Adala S, O'Leary JJ, Womb with a view, Human Fertility (Camb)., 8, (1), 2005, p35 - 40
Smyth, P., Finn, S., Cahill, S., O'Regan, E., Flavin, R., O'Leary, J.J., Sheils, O., Ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic irish cohort of papillary thyroid carcinoma, International Journal of Surgical Pathology, 13, (1), 2005, p1-8
High density SNP and cDNA array analysis in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp515 - 521, [Sheils, O., Smyth, P., Sherlock, J., Martin, C.M., Finn, S., O'Regan, E.M., O'Leary, J.J.]
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM,McGuinness E, Sheils O, O'Leary JJ, p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive, Journal of Clinical Pathology, 58, (5), 2005, p525 - 534
Smyth P, Finn S, Cahill S, O'Regan E, Flavin R, O'Leary JJ, Sheils O, ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma, International Journal of Surgical Pathology, 13, (1), 2005, p1 - 8
DNA Sequencing in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp531 - 539, [Martin, C.M., Picton, S.J. Sheils, O., O'Leary, J.J.]
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ. , p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. , Journal of Clinical Patholology, 58, (5), 2005, p525 - 534
Hughes C, Murphy A, Martin C, Sheils O, O'Leary J, Molecular pathology of prostate cancer, Journal of Clinical Pathology, 58, (7), 2005, p673 - 684
In-cell PCR in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp505 - 513, [O'Leary, J.J., Martin, C.M., Sheils, O.]
Real Time PCR gene analysis in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp495 - 504, [Martin, C.M., Sheils, O, O'Leary, J.J.]
Molecular markers in cervical dyskaryosis in, editor(s)Davies P.O.,Prendiville W , The Clinican's HPV handbook (vol 1), Parthenon Medical Publishing, 2005, pp73 - 88, [Murphy, N., Ring, M., Sheils, O., O'Leary, J.J.]
S. P. Finn, P. Smyth, E. O'Regan, S. Cahill, R. Flavin, J. O'Leary and O. Sheils, Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes, Virchows Arch, 445, (4), 2004, p396-404
Murphy, N., Heffron, C.C.B.B., King, B., Ganuguapati, U.G., Ring, M., McGuinness, E., Sheils, O., O'Leary, J.J., P16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: A potential diagnostic problem, Virchows Archiv, 445, (6), 2004, p610-615
Bofin, A.M., Ytterhus, B., Martin, C., O'Leary, J.J., Hagmar, B.M., Detection and quantitation of HER-2 gene amplification and protein expression in breast carcinoma , American Journal of Clinical Pathology, 122, (1), 2004, p110-119
D. Kane, M. Gogarty, J. O'Leary, I. Silva, N. Bermingham, B. Bresnihan and O. Fitzgerald, Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate, Arthritis and Rheumatism, 50, (10), 2004, p3286-3295
A. M. Cotter, C. M. Martin, J. O'Leary J and S. F. Daly, Increased fetal DNA in the maternal circulation in early pregnancy is associated with an increased risk of preeclampsia, American Journal of Obstetrics and Gynecology, 191, (2), 2004, p515-520
N. Murphy, C. C. Heffron, B. King, U. G. Ganuguapati, M. Ring, E. McGuinness, O. Sheils and J. J. O'Leary, P16(INK4A) positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem, Virchows Archiv, 445, (6), 2004, p610-615
The In-Situ Polymerase Chain Reaction. in, editor(s)Crocker, J., Murray, P.G. , Molecular Biology in Cellular Pathology , John Wiley & Sons, Ltd., 2003, [O'Leary, J.J., Martin, C., Sheils, O]
Sheils, O.M., Finn, S., O'Leary, J.J., Quality-control issues for PCR-based assays in the molecular laboratory , 9, (3), 2003, p165-172
Finn, S.P., Smyth, P., O'Leary, J., Sweeney, E.C., Sheils, O., Comment: Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma, Journal of Clinical Endocrinology and Metabolism, 88, (2), 2003, p938-941
Murphy N, Ring M, Killalea AG, Uhlmann V, O'Donovan M, Mulcahy F, Turner M, Mc Guinness E, Griffin M, Martin, C, Sheils O, O'Leary JJ., p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears, Journal of Clinical Pathology, 56, (1), 2003, p56-63
B. M. Byrne, A. Crowley, F. Taulo, J. Anthony, J. J. O'Leary and C. O'Herlihy, Fetal DNA quantitation in peripheral blood is not useful as a marker of disease severity in women with preeclampsia, Hypertension in pregnancy, 22, (2), 2003, p157-64
Turner, M.J., Martin, C.M., O'Leary, J.J., Letter to the Editor [2] , 2003, - 118
P. Smyth, S. Finn, J. O'Leary and O. Sheils, Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues, Diagnostic Molecular Pathology, 12, (1), 2003, p44-49
S. P. Finn, P. Smyth, J. O'Leary, E. C. Sweeney and O. Sheils, Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma, Journal of Clinical Endocrinology and Metabolism, 88, (2), 2003, p938-941
O'Leary, J.J., Potential viral pathogenic mechanism for new variant inflammatory bowel disease [1] , 2003, - 248
J. Skinner, K. Luettich, M. Ring, J. J. O'Leary and M. J. Turner, Analysis of fetal DNA in the maternal venous blood for abnormalities of chromosomes 13, 16, 18 and 21 in first-trimester spontaneous miscarriage, Journal of obstetrics and gynaecology, 23, (3), 2003, p228-232
Turner, M.J., Martin C.M., O'Leary, J.J. , Detection of fetal Rhesus D gene in whole blood of women booking for routine antenatal care, European journal of obstetrics, gynecology, and reproductive biology, 108, (1), 2003, p29-32
Sheils, O., Finn, S., O'Leary, J., Nucleic acid microarrays: An overview, 9, (3), 2003, pPages 155-158
TaqMan technology and real-time polymerase chain reaction in, editor(s)Crocker J., Murray PG. , Molecular Biology in Cellular Pathology, Wiley & Sons, 2003, pp251 - 268, [O'Leary JJ, Sheils O, Martin C, Crowley A.]
Martin CM, Uhlmann V, Killalea A, Sheils O, O'Leary JJ. , Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder, Molecular psychiatry, 7 Suppl 2, 2002, pS47-s48
Wakefield, A.J. and Puleston, J.M. and Montgomery, S.M. and Anthony, A. and O'Leary, J.J. and Murch, S.H., Review article: The concept of entero-colonic encephalopathy, autism and opioid receptor ligands, Alimentary Pharmacology and Therapeutics, 16, (4), 2002, p663 â" 674
M. Ring, N. Bolger, M. O'Donnell, A. Malkin, N. Bermingham, E. Akpan, F. Mulcahy, M. J. Turner, M. Griffin and J. J. O'Leary, Evaluation of liquid-based cytology in cervical screening of high-risk populations: a split study of colposcopy and genito-urinary medicine populations, Cytopathology, 13, (3), 2002, p152-9
O. Sheils, P. Smyth, S. Finn, E. C. Sweeney and J. J. O'Leary, RET/PTC rearrangements in Hashimoto's thyroiditis, International Journal of Surgical Pathology, 10, (2), 2002, p167-8; author reply 168-9
Sheils, O., Smyth, P., Finn, S., Sweeney, E.C., O'Leary, J.J., Nikiforov, Y., RET/PTC rearrangements in Hashimoto's thyroiditis (multiple letters), International Journal of Surgical Pathology, 10, (2), 2002, p167-169
Uhlmann*, V., Martin*, C.M., Sheils, O., Pilkington, L., Silva, I., Killalea, A., Murch, S.B.,Walker-Smith, J., Thomson, M., Wakefield, A.J., O'Leary, J.J. , Potential viral pathogenic mechanism for new variant inflammatory bowel disease, Molecular pathology, 55, (2), 2002, p84-90
J. Skinner, K. Luettich, M. Ring, J. J. O'Leary and M. J. Turner, Fetal DNA in maternal circulation of first-trimester spontaneous abortions, Obstetrics and gynecology, 97, (3), 2001, p460-463
M. O'Donovan, I. Silva, V. Uhlmann, N. Bermingham, K. Luttich, C. Martin, O. Sheils, A. Killalea, C. Kenny, S. Pileri and J. J. O'Leary, Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma, Molecular pathology, 54, (2), 2001, p80-85
Smyth, P., Sheils, O., Finn, S., Martin, C., O 'Leary, J., Sweeney, E.C, Real time Quantitative Analysis of E-cadherin expression in ret/PTC-1-Activated Thyroid Neoplasms., International Journal of Surgical Pathology , 9, (4), 2001, p265-272
O'Leary J, Kennedy M, Howells D, Silva I, Uhlmann V, Luttich K, Biddolph S, Lucas S, Russell J, Bermingham N, O'Donovan M, Ring M, Kenny C, Sweeney M, Sheils O, Martin C, Picton S, Gatter K, Cellular localisation of HHV-8 in Castleman's disease: is there a link with lymph node vascularity?, Journal of Clinical Pathology - Molecular Pathology, 53, (2), 2000, p69-76
J. J. O'Leary, V. Uhlmann and A. J. Wakefield, Measles virus and autism, Lancet, 356, (9231), 2000, p772
Hackett, N.R., Sawy, T.B., Lee, L.Y., Silva, I., O'Leary, J., Rosengart, T.K., Crystal, R.G., Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo , Molecular Therapy, 2, (6), 2000, p649-656
Uhlmann, V., Prasad, M., Silva, I., Luettich, K., Grande, L., Alonso, L., Thisted, M., Pluzek, K.J., Gorst, J., Ring, M., Sweeney, M., Kenny, C., Martin, C., Russell, J., Bermingham, N., O'Donovan, M., Sheils, O., O'Leary, J.J, Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei, Molecular pathology, 53, (1), 2000, p48-50
Sheils, O.M., O'Leary, J.J., Sweeney, E.C., Differentiation of multicentric origin from intra-organ metastatic spread of hepatocellular carcinomas by comparative genomic hybridization, Journal of Pathology, 192, (1), 2000, p43-51
A. J. Wakefield, A. Anthony, S. H. Murch, M. Thomson, S. M. Montgomery, S. Davies, J. J. O'Leary, M. Berelowitz and J. A. Walker-Smith, Enterocolitis in children with developmental disorders, The American Journal of Gastroenterology, 95, (9), 2000, p2285-2295
O'Leary, J.J., Kennedy, M., Luttich, K., Uhlmann, V., Silva, I., Russell, J., Sheils, O., Ring, M., Sweeney, M., Kenny, C., Bermingham, N., Martin, C., O'Donovan, M., Howells, D., Picton, S., Lucas, S.B, Localisation of HHV-8 in AIDS related lymphadenopathy, Molecular Pathology, 53, (1), 2000, p43-47
O. M. Sheils, J. J. O'Leary and E. C. Sweeney, Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR, The Journal of Pathology, 192, (1), 2000, p32-36
O. M. Sheils, J. O'Eary J, V. Uhlmann, K. Lattich and E. C. Sweeney, ret/PTC-1 Activation in Hashimoto Thyroiditis, International Journal of Surgical Pathology, 8, (3), 2000, p185-189
Kennedy, M.M., Biddolph, S., Lucas, S.B., Howells, D.D., Picton, S., O'D McGee, J., O'Leary, J.J., CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma , Journal of Clinical Pathology - Molecular Pathology, 52, (1), 1999, p32-36
O'Leary, J.J., Shapiro, R.L., Ren, C.J., Chuang, N., Cohen, H.W., Potmesil, M., Antiangiogenic effects of camptothecin analogues 9-amino- 20(S)camptothecin, topotecan, and CPT-11 studied in the mouse cornea model , Clinical Cancer Research, 5, (1), 1999, p181-187
Prasad, M.L., Hyjek, E., Giri, D.D., Ying, L., O'Leary, J.J., Hoda, S.A., Double immunolabeling with cytokeratin and smooth-muscle actin in confirming early invasive carcinoma of breast , American Journal of Surgical Pathology, 23, (2), 1999, p176-181
Kennedy, M.M., Biddolph, S., Lucas, S.B., Howells, D.D., Picton, S., O'D McGee, J., Silva, I., (...), O'Leary, J.J., Cyclin D1 expression and HHV8 in Kaposi sarcoma , Journal of Clinical Pathology, 52, (8), 1999, p569-573
Ely, S.A., Powers, J., Lewis, D., Chang, S., Rubio, A., O'Leary, J., Knowles, D.M., Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma arising in the subarachnoid space, Human Pathology, 30, (8), 1999, p981-984
M. O'Donovan, J. M. Russell, J. J. O'Leary, J. A. Gillan, M. P. Lawler and E. F. Gaffney, Abl expression, tumour grade, and apoptosis in chondrosarcoma, Molecular Pathology, 52, (6), 1999, p341-4
O'Leary, J., Muggia, F.M., Camptothecins: A review of their development and schedules of administration, European Journal of Cancer , 34, (10), 1998, p1500-1508
Kennedy, M.M., Cooper, K., Howells, D.D., Picton, S., Biddolph, S., Lucas, S.B., McGee, J.O'D., O'Leary, J.J., Identification of HHV8 in early Kaposi's sarcoma: Implications for Kaposi's sarcoma pathogenesis , Journal of Clinical Pathology - Molecular Pathology, 51, (1), 1998, p14-20
O'Leary, J., Volm, M., Wasserheit, C., Muggia, F., Searching for Predictive Molecular Markers: Taxanes in Adjuvant and Neoadjuvant Therapies for Breast Cancer , Oncology Reports, 12, (1 SUPPL.1), 1998, p23-27
O'Leary, J.J., Landers, R.J., Crowley, M., Healy, I., O'Donovan, M., Healy, V., Kealy, W.F., (...), Doyle, C.T., Human papillomavirus and mixed epithelial tumors of the endometrium , Human Pathology, 29, (4), 1998, p383-389
O. Flore, S. Rafii, S. Ely, J. J. O'Leary, E. M. Hyjek and E. Cesarman, Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus, Nature, 394, (6693), 1998, p588-92
Uhlmann, V., Rolfs, A., Mix, E., Silva, I., Hully, J., Lu, L., Lohman, K., (...), O'Leary, J.J., A novel, rapid in cell RNA amplification technique for the detection of low copy mRNA transcripts, Journal of Clinical Pathology - Molecular Pathology, 51, (3), 1998, p160-163
O'Leary, J.J., Silva, I., Uhlmann, V., Prasad, M., Luttich, K., Maffei, A., Picton, S., HHV-8 in multiple myeloma: Is this the first paracrine model of human tumorigenesis and do Koch's postulates apply? , Journal of Clinical Pathology - Molecular Pathology, 51, (4), 1998, p201-203
Kennedy, M.M., O'Leary, J.J., Oates, J.L., Lucas, S.B., Howells, D.D., Picton, S., McGee, J.O'D., Human herpes virus 8 (HHV-8) in Kaposi's sarcoma: Lack of association with Bcl-2 and p53 protein expression , Journal of Clinical Pathology - Molecular Pathology, 51, (3), 1998, p155-159
Uhlmann, V., Silva, I., Luttich, K., Picton, S., O'Leary, J.J., In cell amplication , Journal of Clinical Pathology - Molecular Pathology, 51, (3), 1998, p119-130
O'Leary, J.J., Landers, R.J., Silva, I., Uhlmann, V., Crowley, M., Healy, I., Luttich, K., Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix , Journal of Clinical Pathology, 51, (8), 1998, p576-582
Ascani, S. and Piccioli, M. and Poggi, S. and Briskomatis, A. and Bolis, G.B. and Liberati, F. and Frongillo, R. and Caramatti, C. and Fraternali-Orcioni, G. and Gamberi, B. and Zinzani, P.L. and Lazzi, S. and Leoncini, L. and O'Leary, J. and Piccaluga, P.P. and Pileri, S.A., Pyothorax-associated lymphoma: Description of the first two cases detected in Italy, Annals of Oncology, 8, (11), 1997, p1133 â" 1138
O'Leary, J.J., Engels, K., Dada, M.A., The polymerase chain reaction in pathology , Journal of Clinical Pathology, 50, (10), 1997, p805-810
Kennedy, M.M., Lucas, S.B., Russell-Jones, R., Howells, D.D., Picton, S.J., Bardon, A., Comley, I.L., (...), O'Leary, J.J., HHV8 and female Kaposi's sarcoma , Journal of Pathology, 183, (4), 1997, p447-452
J. J. O'Leary, R. J. Landers, M. Crowley, I. Healy, W. F. Kealy, J. Hogan, C. Cullinane, P. Kelehan and C. T. Doyle, Genotypic mapping of HPV and assessment of EBV prevalence in endocervical lesions, Journal of Clinical Pathology, 50, (11), 1997, p904-910
O'Leary, J.J., Landers, R.J., Crowley, M., Healy, I., Kealy, W.F., Hogan, J., Doyle, C.T., Alterations in exon 1 of c-myc and expression of p62(c-myc) in cervical squamous cell carcinoma , Journal of Clinical Pathology , 50, (11), 1997, p896-903
Handley, J. and Hanks, E. and Armstrong, K. and Bingham, A. and Dinsmore, W. and Swann, A. and Evans, M.F. and McGee, J.O.D. and O'Leary, J., Common association of HPV 2 with anogenital warts in prepubertal children, Pediatric Dermatology, 14, (5), 1997, p339 â" 343
O'Leary, J.J., Landers, R.J., Chetty, R., In situ amplification in cytological preparations , Cytopathology, 8, (3), 1997, p148-160
O'Leary, J.J., Kaposi's sarcoma associated herpes virus (KSHV/HHV 8) : Epidemiology, molecular biology and tissue distribution , Journal of Clinical Pathology - Molecular Pathology , 50, (1), 1997, p4-8
Boshoff, C., Talbot, S., Kennedy, M., O'Leary, J., Schulz, T., Chang, Y., HHV8 and skin cancers in immunosuppressed patients. , Lancet, 348, (9020), 1996, p138
O'Leary, J.J., Seeking the cause of Kaposi's sarcoma , Nature Medicine, 2, (8), 1996, p862-863
Koreth, J., O'Leary, J.J., McGee, J.O., Microsatellites and PCR genomic analysis , Journal of Pathology, 178, (3), 1996, p239-248
O'Leary, J.J., Chetty, R., Graham, A.K., McGee, J.O'D., In situ PCR: Pathologist's dream or nightmare? , Journal of Pathology, 178, (1), 1996, p11-20
O'Leary, J.J. and Kennedy, M.M. and Landers, R.J. and O'D McGee, J., In situ amplification: Its application to diagnostic pathology, Current Diagnostic Pathology, 3, (4), 1996, p201 â" 210
Chetty, R., O'Leary, J.J., Biddolph, S.C., Gatter, K.C., Immunohistochemical detection of p53 and Bcl-2 proteins in Hashimoto's thyroiditis and primary thyroid lymphomas , Journal of Clinical Pathology, 48, (3), 1995, p239-241
C. Boshoff, T. F. Schulz, M. M. Kennedy, A. K. Graham, C. Fisher, A. Thomas, J. O. McGee, R. A. Weiss and J. J. O'Leary, Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells, Nature Medicine, 1, (12), 1995, p1274-1278
Chetty, R., Slavin, J.L., O'Leary, J.J., Ansari, N.A., Gatter, K.C., Primary Hodgkin's disease of the lung , Pathology, 27, (2), 1995, p111-114
O'Leary, J.J., Browne, G., Landers, R.J., Crowley, M., Healy, I.B., Street, J.T., Pollock, A.M., (...), Doyle, C.T., The importance of fixation procedures on DNA template and its suitability for solution-phase polymerase chain reaction and PCR in situ hybridization , Histochemical Journal , 26, (4), 1994, p337-346
O'Leary, J.J., Browne, G., Johnson, M.I., Landers, R.J., Crowley, M., Healy, I., Street, J.T., (...), Doyle, C.T., PCR in situ hybridisation detection of HPV 16 in fixed CaSki and fixed SiHa cell lines, Journal of Clinical Pathology, 47, (10), 1994, p933-938
O'Leary, J.J., Browne, G., Landers, R., Crowley, M., Healy, I., Johnson, M.I., Doyle, C.T., New nucleic acid amplification techniques in diagnostic pathology, Journal of the European Academy of Dermatology and Venereology, 3, (1), 1994, p78-86
Landers, R.J., O'Leary, J.J., Crowley, M., Healy, I., Annis, P., Burke, L., O'Brien, D., (...), Doyle, C.T., Epstein-Barr virus in normal, pre-malignant, and malignant lesions of the uterine cervix , Journal of Clinical Pathology, 46, (10), 1993, p931-935
Doyle, C.T., O'Leary, J.J., The search for the universal fixative or 'magic juice' , Journal of Pathology , 166, (4), 1992, p331-332
Research Expertise
Description
Biomarkers of disease. Cervical Cancer. Development of array technologies. Molecular pathology. Prostate cancer.Recognition
Representations
Member, DMMC Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes
Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms.
Member, Centre for Molecular Research in Cancer (Proposed), This consortium combines researchers with common interest in understanding cell cycle signaling and regulation with specific focus on two key cancer-related processes (cell cycle control, apoptosis) and/or three specific malignancy types (oesophageal, prostate and haematological).
Invitee, Breast Cancer Consortium (Proposed), Investigators to be invited to participate in Breast Cancer workshop with a view to establishing formal consortium and informal individual collaborations.Last updated : 19 November 2004. Extract from DMMC Research Database