Dr. Rachel Mary Mc Loughlin
Professor in Immunology, Biochemistry

Vozza EG, Daly CM, O'Rourke SA, Fitzgerald HK, Dunne A, McLoughlin RM., Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival., mBio : Duplicate, marked for deletion, 15, (1), 2024, pe0257123 Journal Article, 2024 DOI

McCarthy KN, Hone S, McLoughlin RM, Mills KHG., IL-17 and IFN-"-producing respiratory tissue resident memory CD4"T cells persist for decades in adults immunized as children with whole cell pertussis vaccines., The Journal of infectious diseases, 2024, pjiae034 Journal Article, 2024 DOI

Ultán P. Doherty, Rachel McLoughlin, Tracey Claxton, Arthur White, gateTree: A user-informed tree algorithm for population identification in flow cytometry, International Workshop on Statistical Modelling 2024, Durham, United Kingdom, 14 to 19 July 2024, edited by Jochen Einbeck, Reza Drikvandi, Georgios Karagiannis, Konstantinos Perrakis, Qing Zhang , 2024, pp108 - 113 Conference Paper, 2024 URL

Vozza, E.G. and Kelly, A.M. and Daly, C.M. and O†Rourke, S.A. and Carlile, S.R. and Morris, B. and Dunne, A. and McLoughlin, R.M., Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis, Cell Death Discovery, 10, (1), 2024 Journal Article, 2024 DOI

Kelly AM, McCarthy KN, Claxton TJ, Carlile SR, O'Brien EC, Vozza EG, Mills KH, McLoughlin RM., IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection., JCI insight, 9, (13), 2024, pe178216 Journal Article, 2024 DOI

Clowry Juliann, Dempsey Daniel J, Claxton Tracey J, Towell Aisling M, Turley Mary B, Sutton Marti, Geoghegan Joan A, Kezic Sanj, Jakasa Ivon, White Arthu, Irvine Alan D, McLoughlin Rachel M, Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis, 9, (9), 2024, p1-19 Journal Article, 2024 DOI URL

Baran, M. and Feriotti, C. and McGinley, A. and Carlile, S.R. and Jiang, Z. and Calderon-Gonzalez, R. and Dumigan, A. and Sá-Pessoa, J. and Sutton, C.E. and Kearney, J. and McLoughlin, R.M. and Mills, K.H.G. and Fitzgerald, K.A. and Bengeochea, J.A. and Bowie, A.G., PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection, Cell Reports, 42, (4), 2023 Journal Article, 2023 DOI TARA - Full Text

Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and Brien, E.C.O. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and Donnell, J.S.O. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and Neill, L.A.J.O., Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon, Nature Communications, 14, (1), 2023 Journal Article, 2023 TARA - Full Text DOI

Curham, L.M. and Mannion, J.M. and Daly, C.M. and Wilk, M.M. and Borkner, L. and Lalor, S.J. and McLoughlin, R.M. and Mills, K.H.G., Bystander activation of Bordetella pertussis-induced nasal tissue-resident memory CD4 T cells confers heterologous immunity to Klebsiella pneumoniae, European Journal of Immunology, 2023 Journal Article, 2023 DOI TARA - Full Text

Ryan, T.A.J. and Hooftman, A. and Rehill, A.M. and Johansen, M.D. and O†Brien, E.C. and Toller-Kawahisa, J.E. and Wilk, M.M. and Day, E.A. and Weiss, H.J. and Sarvari, P. and Vozza, E.G. and Schramm, F. and Peace, C.G. and Zotta, A. and Miemczyk, S. and Nalkurthi, C. and Hansbro, N.G. and McManus, G. and O†Doherty, L. and Gargan, S. and Long, A. and Dunne, J. and Cheallaigh, C.N. and Conlon, N. and Carty, M. and Fallon, P.G. and Mills, K.H.G. and Creagh, E.M. and O†Donnell, J.S. and Hertzog, P.J. and Hansbro, P.M. and McLoughlin, R.M. and Wygrecka, M. and Preston, R.J.S. and ZasÅ'ona, Z. and O†Neill, L.A.J., Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon (Nature Communications, (2023), 14, 1, (3513), 10.1038/s41467-023-39174-1), Nature Communications, 14, (1), 2023 Journal Article, 2023 TARA - Full Text DOI

Douglas EJA, Palk N, Brignoli T, Altwiley D, Boura M, Laabei M, Recker M, Cheung GYC, Liu R, Hsieh RC, Otto M, O'Brien E, McLoughlin RM, Massey RC., Extensive remodelling of the cell wall during the development of Staphylococcus aureus bacteraemia., eLife, 12, 2023, pRP87026 Journal Article, 2023 DOI

Ward J, Zhang S, Sikora A, Michalski R, Yin Y, D'Alessio A, McLoughlin RM, Jaquet V, Fieschi F, Knaus UG., VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity., Redox biology, 67, 2023, p102905 Journal Article, 2023 DOI

Mannion JM, Segal BM, McLoughlin RM, Lalor SJ., Respiratory tract Moraxella catarrhalis and Klebsiella pneumoniae can promote pathogenicity of myelin-reactive Th17 cells., Mucosal immunology, 16, (4), 2023, p399-407 Journal Article, 2023 DOI

Cooper AJR, Clegg J, Cassidy FC, Hogan AE, McLoughlin RM., Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity., Microorganisms, 10, (1), 2022 Journal Article, 2022 DOI

Mannion JM, McLoughlin RM, Lalor SJ, The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease, Clinical Reviews in Allergy & Immunology,, March 11, 2022 Journal Article, 2022 DOI

Stevens E.J., Morse D.J., Bonini D., Duggan S., Brignoli T., Recker M., Lees J.A., Croucher N.J., Bentley S., Wilson D.J., Earle S.G., Dixon R., Nobbs A., Jenkinson H., van Opijnen T., Thibault D., Wilkinson O.J., Dillingham M.S., Carlile S., McLoughlin R.M., Massey R.C., Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae, Microbial Genomics, 8, (4), 2022 Journal Article, 2022 DOI

Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236 Journal Article, 2022

Kelly, A.M. and Leech, J.M. and Doyle, S.L. and McLoughlin, R.M., Staphylococcus aureus-induced immunosuppression mediated by IL-10 and IL-27 facilitates nasal colonisation, PLoS Pathogens, 18, (7), 2022 Journal Article, 2022 DOI

Fox PG, Schiavetti F, Rappuoli R, McLoughlin RM, Bagnoli F, Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins., mBio, 2021 Journal Article, 2021

O'Brien MB, McLoughlin RM, Roche C, Nelson CD, Meade KG, Effect of IL-8 haplotype on temporal profile in circulating concentrations of interleukin 8 and 25(OH) vitamin D in Holstein-Friesian calves., Veterinary immunology and immunopathology, 2021 Journal Article, 2021

Vozza EG, Mulcahy ME, McLoughlin RM, Making the Most of the Host; Targeting the Autophagy Pathway Facilitates Staphylococcus aureus Intracellular Survival in Neutrophils., Frontiers in immunology, 2021 Journal Article, 2021

Clegg J, Soldaini E, McLoughlin RM, Rittenhouse S, Bagnoli F, Phogat S, Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies., Frontiers in immunology, 2021 Journal Article, 2021

Megan B. O"Brien, Charlotte L. Beynon, Rachel M. McLoughlin, Kieran G. Meade, The immune response in bovine primary dermal fibroblasts is influenced by Interleukin 8 promoter haplotype and vitamin D, Veterinary Immunology and Immunopathology, 238, 2021, p110291 Journal Article, 2021

Duggan S, Laabei M, Alnahari AA, O'Brien EC, Lacey KA, Bacon L, Heesom K, Fu CL, Otto M, Skaar E, McLoughlin RM, Massey RC, A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus., Infection and immunity, 2020 Journal Article, 2020

Clegg J, Soldaini E, Bagnoli F, McLoughlin RM, Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections., Trends in immunology, 2020 Journal Article, 2020

Kelly AM, McLoughlin RM, Target the Host, Kill the Bug; Targeting Host Respiratory Immunosuppressive Responses as a Novel Strategy to Improve Bacterial Clearance During Lung Infection., Frontiers in immunology, 2020 Journal Article, 2020

Edwards, S.C. and Sutton, C.E. and Ladell, K. and Grant, E.J. and McLaren, J.E. and Roche, F. and Dash, P. and Apiwattanakul, N. and Awad, W. and Miners, K.L. and Lalor, S.J. and Ribot, J.C. and Baik, S. and Moran, B. and McGinley, A. and Pivorunas, V. and Dowding, L. and Macoritto, M. and Paez-Cortez, J. and Slavin, A. and Anderson, G. and Silva-Santos, B. and Hokamp, K. and Price, D.A. and Thomas, P.G. and McLoughlin, R.M. and Mills, K.H.G., A population of proinflammatory T cells coexpresses αβ and γΎ T cell receptors in mice and humans, Journal of Experimental Medicine, 217, (5), 2020 Journal Article, 2020 DOI TARA - Full Text

Mulcahy ME, O'Brien EC, O'Keeffe KM, Vozza EG, Leddy N, McLoughlin RM, Manipulation of Autophagy and Apoptosis Facilitates Intracellular Survival of Staphylococcus aureus in Human Neutrophils., Frontiers in immunology, 2020 Journal Article, 2020

O'Brien MB, McLoughlin RM, Meade KG, Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle., Veterinary immunology and immunopathology, 2020 Journal Article, 2020

Cooper AJR, Lalor SJ, McLoughlin RM, Activation of Human V"2⁺ "" T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity., Journal of immunology (Baltimore, Md. : 1950), 2020 Journal Article, 2020

Clowry, J., Irvine, A.D., McLoughlin, R.M., Next-generation anti"Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?, Journal of Allergy and Clinical Immunology, 143, (1), 2019, p78-81 Journal Article, 2019 TARA - Full Text DOI

Lacey K.A, Mulcahy M.E, Towell A.M, Geoghegan J.A, McLoughlin R.M, Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target, PLoS pathogens, 15, (4), 2019, pe1007713- Journal Article, 2019 TARA - Full Text URL DOI

O'Brien E.C, McLoughlin R.M, Considering the â€~Alternatives†for Next-Generation Anti-Staphylococcus aureus Vaccine Development, Trends in Molecular Medicine, 25, (3), 2019, p171 - 184 Journal Article, 2019 DOI URL

Connolly R, Denton M.D, Humphreys H, McLoughlin R.M, Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?, Kidney International, 95, (3), 2019, p518 - 525 Journal Article, 2019 TARA - Full Text DOI URL

Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM., The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen., Infection and immunity, 85, (12), 2017, pe00549-17- Journal Article, 2017 TARA - Full Text DOI

Rudkin, J.K. and McLoughlin, R.M. and Preston, A. and Massey, R.C., Bacterial toxins: Offensive, defensive, or something else altogether?, PLoS Pathogens, 13, (9), 2017, e1006452.- Journal Article, 2017 DOI TARA - Full Text

Stojkovic B, Mullen M.P, Donofrio G, McLoughlin R.M, Meade K.G, Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle, Veterinary Immunology and Immunopathology, 184, 2017, p18 - 28 Journal Article, 2017 DOI URL

Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 - Journal Article, 2017 DOI

Zaslona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LA., The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma., American Journal of Physiology Lung Cellular and Molecular Physiology, 2017, pL855-L860 Journal Article, 2017 DOI

Leech JM, Lacey KA, Mulcahy ME, Medina E, McLoughlin RM, IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections., 198, (6), 2017, p2352-2365 Journal Article, 2017 DOI TARA - Full Text

Lacey KA, Geoghegan JA, McLoughlin RM, The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens., Pathogens (Basel, Switzerland), 5, (1), 2016, p22- Journal Article, 2016 DOI TARA - Full Text

Stojkovic B, McLoughlin R.M, Meade K.G, In vivo relevance of polymorphic Interleukin 8 promoter haplotype for the systemic immune response to LPS in Holstein-Friesian calves, Veterinary Immunology and Immunopathology, 182, 2016, p1 - 10 Journal Article, 2016 URL DOI

Mulcahy M.E, McLoughlin R.M, Staphylococcus aureus and influenza a virus: Partners in coinfection, mBio, 7, (6), 2016, e02068-16 Journal Article, 2016 DOI TARA - Full Text URL

Immune Response to Staphylococcus aureus in, Staphylococcus: Genetics and Physiology., Caister Academic Press, 2016, pp335--388 , [Aisling F. Brown, Rachel M. McLoughlin] Book Chapter, 2016

Mulcahy M.E, McLoughlin R.M, Hostâ€"Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization, Trends in Microbiology, 24, (11), 2016, p872 - 886 Journal Article, 2016 DOI URL

Lalor S.J, McLoughlin R.M, Memory γÎ" T Cellsâ€"Newly Appreciated Protagonists in Infection and Immunity, Trends in Immunology, 37, (10), 2016, p690 - 702 Journal Article, 2016 DOI URL

Mulcahy M.E, Leech J.M, Renauld J.-C, Mills K.H.G, McLoughlin R.M, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunology, 9, (6), 2016, p1429 - 1441 Journal Article, 2016 TARA - Full Text URL DOI

O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM, Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection., Infection and immunity, 83, (9), 2015, p3445- Journal Article, 2015 DOI TARA - Full Text

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226 Journal Article, 2015 TARA - Full Text DOI

The importance of cell mediated immunity for bacterial vaccines in, Vaccine Design: Innovative Approaches and Novel Strategies, Caister Academic Press, 2015, pp220 - 249, [Alison G.Murphy & Rachel M. McLoughlin] Book Chapter, 2015 DOI

Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design., Frontiers in immunology, 4, 2014, p507 Journal Article, 2014 DOI TARA - Full Text

Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG, TRAM is required for TLR2 endosomal signaling to type I IFN induction., Journal of immunology (Baltimore, Md. : 1950), 193, (12), 2014, p6090-102 Journal Article, 2014 TARA - Full Text DOI

Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus colonization: modulation of host immune response and impact on vaccine design, Frontiers in Immunology, 4, 2014, p507- Journal Article, 2014 TARA - Full Text

Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, (9), 2014, p1479-1484 Journal Article, 2014 TARA - Full Text DOI

Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA, Interleukin-6 signaling drives fibrosis in unresolved inflammation., Immunity, 40, (1), 2014, p40-50 Journal Article, 2014 DOI

Murphy, AG, O'Keeffe, KM, Lalor, SJ, Maher, BM, Mills, KHG, McLoughlin, RM, Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection, JOURNAL OF IMMUNOLOGY, 192, (8), 2014, p3697-3708 Journal Article, 2014 DOI TARA - Full Text

Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection., Infection and immunity, 81, (12), 2013, p4478-4489 Journal Article, 2013 DOI

Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH, Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine., PLoS pathogens, 9, (4), 2013, pe1003264 Journal Article, 2013 DOI TARA - Full Text

Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM, Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin., PLoS Pathogens, 8, (12), 2012, pe1003092 Journal Article, 2012 TARA - Full Text DOI

McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR, Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 42, (3), 2012, p392-404 Journal Article, 2012 DOI

Chi A, Wildfire J, McLoughlin R, Wood RA, Bloomberg GR, Kattan M, Gergen P, Gold DR, Witter F, Chen T, Holick M, Visness C, Gern J, O'Connor GT, Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 41, (6), 2011, p842-50 Journal Article, 2011

Cohen-Poradosu R, McLoughlin RM, Lee JC, Kasper DL, Bacteroides fragilis-stimulated interleukin-10 contains expanding disease., The Journal of infectious diseases, 204, (3), 2011, p363-71 Journal Article, 2011 DOI

McLoughlin, R.M., Mills, K.H.G., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma, Journal of Allergy and Clinical Immunology, 127, (5), 2011, p1097-1107 Journal Article, 2011 DOI

McLoughlin RM, Topley, N, Switching on EMT in the peritoneal membrane: considering the evidence., Nephrology Dialysis and Transplant, 26, (1), 2011, p12 - 15 Journal Article, 2011

Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA, Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells., Journal of immunology (Baltimore, Md. : 1950), 184, (4), 2010, p2130-9 Journal Article, 2010

Weidenmaier C, McLoughlin R.M, Lee J.C, The Zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism, PLoS ONE, 5, (10), 2010 Journal Article, 2010 DOI URL

Lee JC, Greenwich JL, Zhanel GG, Han X, Cumming A, Saward L, McLoughlin RM, Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection., Infection and immunity, 78, (10), 2010, p4176-86 Journal Article, 2010

Ni J, McLoughlin RM, Brodovitch A, Moulin P, Brouckaert P, Casadei B, Feron O, Topley N, Balligand JL, Devuyst O, Nitric oxide synthase isoforms play distinct roles during acute peritonitis., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25, (1), 2010, p86-96 Journal Article, 2010

McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC, Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4., PLoS pathogens, 6, (11), 2010, pe1001191 Journal Article, 2010 URL DOI TARA - Full Text

Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE, Characterization of regulatory T cells in urban newborns., Clinical and molecular allergy : CMA, 7, 2009, p8 Journal Article, 2009

Immunomodulation by zwitterionic polysaccharides in, Microbial Glycobiology: Structure, Relevance and Applications, Elsevier, 2009, [McLoughlin RM, Kasper DL] Book Chapter, 2009

Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ, IL-6 regulates neutrophil trafficking during acute inflammation via STAT3., Journal of immunology (Baltimore, Md. : 1950), 181, (3), 2008, p2189-95 Journal Article, 2008

McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO, IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection., Journal of immunology (Baltimore, Md. : 1950), 181, (2), 2008, p1323-32 Journal Article, 2008

Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA, Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis., Arthritis and rheumatism, 54, (5), 2006, p1662-72 Journal Article, 2006

Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO, Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection., Antimicrobial agents and chemotherapy, 50, (11), 2006, p3856-60 Journal Article, 2006

Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL, A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2., The Journal of experimental medicine, 203, (13), 2006, p2853-63 Journal Article, 2006

McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC, CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections., Proceedings of the National Academy of Sciences of the United States of America, 103, (27), 2006, p10408-13 Journal Article, 2006

McLoughlin RM, Resolving peritoneal inflammation :Flicking the right "switches". , Peritoneal Dialysis International, 25, 2005, p223 - 229 Journal Article, 2005

Ni J, Cnops Y, McLoughlin RM, Topley N, Devuyst O, Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 25 Suppl 3, 2005, pS11-4 Journal Article, 2005

Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, Topley N, Jones SA, Viral IL-6 blocks neutrophil infiltration during acute inflammation., Journal of immunology (Baltimore, Md. : 1950), 175, (6), 2005, p4024-9 Journal Article, 2005

Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M, Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling., Nature medicine, 11, (8), 2005, p845-52 Journal Article, 2005

McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA, IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation., Proceedings of the National Academy of Sciences of the United States of America, 102, (27), 2005, p9589-94 Journal Article, 2005

McLoughlin RM, Hurst SM, Nowell MA, Harris DA, Horiuchi S, Morgan LW, Wilkinson TS, Yamamoto N, Topley N, Jones SA, Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms., Journal of immunology (Baltimore, Md. : 1950), 172, (9), 2004, p5676-83 Journal Article, 2004

McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N, Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation., The Journal of clinical investigation, 112, (4), 2003, p598-607 Journal Article, 2003

Mortier S, De Vriese AS, McLoughlin RM, Topley N, Schaub TP, Passlick-Deetjen J, Lameire NH, Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane., Journal of the American Society of Nephrology : JASN, 14, (5), 2003, p1296-306 Journal Article, 2003

Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA, Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells., Journal of immunology (Baltimore, Md. : 1950), 169, (9), 2002, p5244-51 Journal Article, 2002

Coles B, Bloodsworth A, Eiserich JP, Coffey MJ, McLoughlin RM, Giddings JC, Lewis MJ, Haslam RJ, Freeman BA, O'Donnell VB, Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP., The Journal of biological chemistry, 277, (8), 2002, p5832-40 Journal Article, 2002

Hurst S.M, Wilkinson T.S, McLoughlin R.M, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller G.M, Topley N, Jones S.A, IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation, Immunity, 14, (6), 2001, p705 - 714 Journal Article, 2001 URL DOI

Robson RL, McLoughlin RM, Witowski J, Loetscher P, Wilkinson TS, Jones SA, Topley N, Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo., Journal of immunology (Baltimore, Md. : 1950), 167, (2), 2001, p1028-38 Journal Article, 2001

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