Dr. Rachel Mary Mc Loughlin
Professor in Immunology, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Mannion JM, McLoughlin RM, Lalor SJ, The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease, Clinical Reviews in Allergy & Immunology,, March 11, 2022
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236
Cooper AJR, Clegg J, Cassidy FC, Hogan AE, McLoughlin RM., Human MAIT Cells Respond to Staphylococcus aureus with Enhanced Anti-Bacterial Activity., Microorganisms, 10, (1), 2022
Fox PG, Schiavetti F, Rappuoli R, McLoughlin RM, Bagnoli F, Staphylococcal Protein A Induces Leukocyte Necrosis by Complexing with Human Immunoglobulins., mBio, 2021
Clegg J, Soldaini E, McLoughlin RM, Rittenhouse S, Bagnoli F, Phogat S, Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies., Frontiers in immunology, 2021
O'Brien MB, McLoughlin RM, Roche C, Nelson CD, Meade KG, Effect of IL-8 haplotype on temporal profile in circulating concentrations of interleukin 8 and 25(OH) vitamin D in Holstein-Friesian calves., Veterinary immunology and immunopathology, 2021
Vozza EG, Mulcahy ME, McLoughlin RM, Making the Most of the Host; Targeting the Autophagy Pathway Facilitates Staphylococcus aureus Intracellular Survival in Neutrophils., Frontiers in immunology, 2021
Douglas E, Brignoli T, Recker M, O"Brien E, McLoughlin RM, Massey RC, Self-sensitisation of Staphylococcus aureus to the antimicrobial factors found in human blood, 2021
Megan B. O"Brien, Charlotte L. Beynon, Rachel M. McLoughlin, Kieran G. Meade, The immune response in bovine primary dermal fibroblasts is influenced by Interleukin 8 promoter haplotype and vitamin D, Veterinary Immunology and Immunopathology, 238, 2021, p110291
O'Brien MB, McLoughlin RM, Meade KG, Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle., Veterinary immunology and immunopathology, 2020
Duggan S, Laabei M, Alnahari AA, O'Brien EC, Lacey KA, Bacon L, Heesom K, Fu CL, Otto M, Skaar E, McLoughlin RM, Massey RC, A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus., Infection and immunity, 2020
Mulcahy ME, O'Brien EC, O'Keeffe KM, Vozza EG, Leddy N, McLoughlin RM, Manipulation of Autophagy and Apoptosis Facilitates Intracellular Survival of Staphylococcus aureus in Human Neutrophils., Frontiers in immunology, 2020
Cooper AJR, Lalor SJ, McLoughlin RM, Activation of Human V"2+ "" T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity., Journal of immunology (Baltimore, Md. : 1950), 2020
Clegg J, Soldaini E, Bagnoli F, McLoughlin RM, Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections., Trends in immunology, 2020
Kelly AM, McLoughlin RM, Target the Host, Kill the Bug; Targeting Host Respiratory Immunosuppressive Responses as a Novel Strategy to Improve Bacterial Clearance During Lung Infection., Frontiers in immunology, 2020
O'Brien E.C, McLoughlin R.M, Considering the â~Alternativesâ for Next-Generation Anti-Staphylococcus aureus Vaccine Development, Trends in Molecular Medicine, 25, (3), 2019, p171 - 184
Keenan A. Lacey, Alice Prince, Michelle E. Mulcahy, Aisling M. Towell, Joan A. Geoghegan, Rachel M. McLoughlin, Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target, PLOS Pathogens, 15, (4), 2019, pe1007713
Lacey K.A, Mulcahy M.E, Towell A.M, Geoghegan J.A, McLoughlin R.M, Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target, PLoS pathogens, 15, (4), 2019, pe1007713-
Clowry, J., Irvine, A.D., McLoughlin, R.M., Next-generation anti"Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?, Journal of Allergy and Clinical Immunology, 143, (1), 2019, p78-81
Connolly R, Denton M.D, Humphreys H, McLoughlin R.M, Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?, Kidney International, 95, (3), 2019, p518 - 525
Leech JM, Lacey KA, Mulcahy ME, Medina E, McLoughlin RM, IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections., 198, (6), 2017, p2352-2365
Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 -
Zaslona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LA., The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma., American Journal of Physiology Lung Cellular and Molecular Physiology, 2017, pL855-L860
Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM., The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen., Infection and immunity, 85, (12), 2017, pe00549-17 -
Stojkovic B, Mullen M.P, Donofrio G, McLoughlin R.M, Meade K.G, Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle, Veterinary Immunology and Immunopathology, 184, 2017, p18 - 28
Rudkin, J.K. and McLoughlin, R.M. and Preston, A. and Massey, R.C., Bacterial toxins: Offensive, defensive, or something else altogether?, PLoS Pathogens, 13, (9), 2017, e1006452.-
Mulcahy M.E, McLoughlin R.M, Hostâ"Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization, Trends in Microbiology, 24, (11), 2016, p872 - 886
Mulcahy M.E, McLoughlin R.M, Staphylococcus aureus and influenza a virus: Partners in coinfection, mBio, 7, (6), 2016, e02068-16
Lalor S.J, McLoughlin R.M, Memory γÎ" T Cellsâ"Newly Appreciated Protagonists in Infection and Immunity, Trends in Immunology, 37, (10), 2016, p690 - 702
Immune Response to Staphylococcus aureus in, Staphylococcus: Genetics and Physiology., Caister Academic Press , 2016, pp335--388 , [Aisling F. Brown, Rachel M. McLoughlin]
Lacey KA, Geoghegan JA, McLoughlin RM, The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens., Pathogens (Basel, Switzerland), 5, (1), 2016, p22-
Mulcahy M.E, Leech J.M, Renauld J.-C, Mills K.H.G, McLoughlin R.M, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunology, 9, (6), 2016, p1429 - 1441
Stojkovic B, McLoughlin R.M, Meade K.G, In vivo relevance of polymorphic Interleukin 8 promoter haplotype for the systemic immune response to LPS in Holstein-Friesian calves, Veterinary Immunology and Immunopathology, 182, 2016, p1 - 10
Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM, Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection., PLoS pathogens, 11, (11), 2015, pe1005226
O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM, Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection., Infection and immunity, 83, (9), 2015, p3445-
The importance of cell mediated immunity for bacterial vaccines in, Vaccine Design: Innovative Approaches and Novel Strategies, Caister Academic Press, 2015, pp220 - 249, [Alison G.Murphy & Rachel M. McLoughlin]
Alison G. Murphy and Rachel M. McLoughlin, The Importance of Cell Mediated Immunity for Bacterial Vaccines, Advanced Vaccine Research Methods for the Decade of Vaccines, 2015, p219--250
Murphy A.G, O'Keeffe K.M, Lalor S.J, Maher B.M, Mills K.H.G, McLoughlin R.M, Staphylococcus aureus infection of mice expands a population of memory γΎ T cells that are protective against subsequent infection (Journal of Immunology (2014) 192 (3697-3708)), Journal of Immunology, 194, (9), 2015, p4588-
Murphy, AG, O'Keeffe, KM, Lalor, SJ, Maher, BM, Mills, KHG, McLoughlin, RM, Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection, JOURNAL OF IMMUNOLOGY, 192, (8), 2014, p3697-3708
Misstear, K., Mcneela, E.A., Murphy, A.G., (...), Mcloughlin, R.M., Lavelle, E.C. , Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus, Journal of Infectious Diseases, 209, (9), 2014, p1479-1484
Stack, J., Doyle, S.L., Connolly, D.J., (...), Paludan, S.R., Bowie, A.G. , TRAM is required for TLR2 endosomal signaling to type I IFN induction, Journal of Immunology, 193, (12), 2014, p6090-6102
Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design., Frontiers in immunology, 4, 2014, p507
Stack J, Doyle SL, Connolly DJ, Reinert LS, O'Keeffe KM, McLoughlin RM, Paludan SR, Bowie AG, TRAM is required for TLR2 endosomal signaling to type I IFN induction., Journal of immunology (Baltimore, Md. : 1950), 193, (12), 2014, p6090-102
Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC, Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus., The Journal of infectious diseases, 209, (9), 2014, p1479-1484
Brown AF, Leech JM, Rogers TR, McLoughlin RM, Staphylococcus aureus colonization: modulation of host immune response and impact on vaccine design, Frontiers in Immunology, 4, 2014, p507-
Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA, Interleukin-6 signaling drives fibrosis in unresolved inflammation., Immunity, 40, (1), 2014, p40-50
Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH, Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine., PLoS pathogens, 9, (4), 2013, pe1003264
Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM, Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection., Infection and immunity, 81, (12), 2013, p4478-4489
McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR, Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 42, (3), 2012, p392-404
Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM, Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin., PLoS Pathogens, 8, (12), 2012, pe1003092
Cohen-Poradosu R, McLoughlin RM, Lee JC, Kasper DL, Bacteroides fragilis-stimulated interleukin-10 contains expanding disease., The Journal of infectious diseases, 204, (3), 2011, p363-71
Chi A, Wildfire J, McLoughlin R, Wood RA, Bloomberg GR, Kattan M, Gergen P, Gold DR, Witter F, Chen T, Holick M, Visness C, Gern J, O'Connor GT, Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 41, (6), 2011, p842-50
McLoughlin RM, Topley, N, Switching on EMT in the peritoneal membrane: considering the evidence. , Nephrology Dialysis and Transplant, 26, (1), 2011, p12 - 15
McLoughlin, R.M., Mills, K.H.G., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma, Journal of Allergy and Clinical Immunology, 127, (5), 2011, p1097-1107
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA, Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells., Journal of immunology (Baltimore, Md. : 1950), 184, (4), 2010, p2130-9
Lee JC, Greenwich JL, Zhanel GG, Han X, Cumming A, Saward L, McLoughlin RM, Modulation of the local neutrophil response by a novel hyaluronic acid-binding peptide reduces bacterial burden during staphylococcal wound infection., Infection and immunity, 78, (10), 2010, p4176-86
Weidenmaier C, McLoughlin R.M, Lee J.C, The Zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism, PLoS ONE, 5, (10), 2010
Ni J, McLoughlin RM, Brodovitch A, Moulin P, Brouckaert P, Casadei B, Feron O, Topley N, Balligand JL, Devuyst O, Nitric oxide synthase isoforms play distinct roles during acute peritonitis., Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25, (1), 2010, p86-96
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC, Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4., PLoS pathogens, 6, (11), 2010, pe1001191
Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE, Characterization of regulatory T cells in urban newborns., Clinical and molecular allergy : CMA, 7, 2009, p8
Immunomodulation by zwitterionic polysaccharides in, Microbial Glycobiology: Structure, Relevance and Applications, Elsevier, 2009, [McLoughlin RM, Kasper DL]
Fielding CA, McLoughlin RM, McLeod L, Colmont CS, Najdovska M, Grail D, Ernst M, Jones SA, Topley N, Jenkins BJ, IL-6 regulates neutrophil trafficking during acute inflammation via STAT3., Journal of immunology (Baltimore, Md. : 1950), 181, (3), 2008, p2189-95
McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO, IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection., Journal of immunology (Baltimore, Md. : 1950), 181, (2), 2008, p1323-32
Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO, Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection., Antimicrobial agents and chemotherapy, 50, (11), 2006, p3856-60
McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC, CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections., Proceedings of the National Academy of Sciences of the United States of America, 103, (27), 2006, p10408-13
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA, Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis., Arthritis and rheumatism, 54, (5), 2006, p1662-72
Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL, A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2., The Journal of experimental medicine, 203, (13), 2006, p2853-63
McLoughlin RM, Resolving peritoneal inflammation :Flicking the right "switches". , Peritoneal Dialysis International, 25, 2005, p223 - 229
Ni J, Cnops Y, McLoughlin RM, Topley N, Devuyst O, Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis., Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 25 Suppl 3, 2005, pS11-4
Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, Topley N, Jones SA, Viral IL-6 blocks neutrophil infiltration during acute inflammation., Journal of immunology (Baltimore, Md. : 1950), 175, (6), 2005, p4024-9
McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA, IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation., Proceedings of the National Academy of Sciences of the United States of America, 102, (27), 2005, p9589-94
Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M, Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling., Nature medicine, 11, (8), 2005, p845-52
McLoughlin RM, Hurst SM, Nowell MA, Harris DA, Horiuchi S, Morgan LW, Wilkinson TS, Yamamoto N, Topley N, Jones SA, Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms., Journal of immunology (Baltimore, Md. : 1950), 172, (9), 2004, p5676-83
Mortier S, De Vriese AS, McLoughlin RM, Topley N, Schaub TP, Passlick-Deetjen J, Lameire NH, Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane., Journal of the American Society of Nephrology : JASN, 14, (5), 2003, p1296-306
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N, Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation., The Journal of clinical investigation, 112, (4), 2003, p598-607
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA, Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells., Journal of immunology (Baltimore, Md. : 1950), 169, (9), 2002, p5244-51
Coles B, Bloodsworth A, Eiserich JP, Coffey MJ, McLoughlin RM, Giddings JC, Lewis MJ, Haslam RJ, Freeman BA, O'Donnell VB, Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP., The Journal of biological chemistry, 277, (8), 2002, p5832-40
Hurst S.M, Wilkinson T.S, McLoughlin R.M, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller G.M, Topley N, Jones S.A, IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation, Immunity, 14, (6), 2001, p705 - 714
Robson RL, McLoughlin RM, Witowski J, Loetscher P, Wilkinson TS, Jones SA, Topley N, Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo., Journal of immunology (Baltimore, Md. : 1950), 167, (2), 2001, p1028-38
Davenport A, Li F, Robson R, Wilkinson TS, McLoughlin RM, Topley N. , Early Peritoneal Responses to Bacterial Invasion: Cellular Exudation, Sepsis, 3, (4), 1999, p303-
Research Expertise
Projects
- Title
- Skin delivery and tissue-resident T cell responses: implications for innovative vaccines
- Funding Agency
- GlaxoSmithKline
- Date From
- 2021
- Date To
- 2025
- Title
- Characterisation and exploitation of skin resident memory CD4 T cells for novel vaccines for Staphylococcus aureus
- Funding Agency
- GlaxoSmithKline
- Date From
- 2019
- Date To
- 2024
- Title
- Vaccination:Knowledge is Power
- Funding Agency
- Health Research Board
- Date From
- 2018
- Date To
- 2022
- Title
- Delineating immune memory to Staphylococcus aureus
- Funding Agency
- Science Foundation Ireland
- Date From
- 2018
- Date To
- 2022
- Title
- Staphylococcus aureus induced immunosuppressive memory: consequences for bug and for host
- Summary
- 202846/Z/16/Z
- Funding Agency
- Wellcome Trust
- Date From
- 01/09/17
- Date To
- 31/08/21
- Title
- Profiling immune signatures predictive of outcome in Staphylococcus aureus infection: Advancing next-generation vaccine design
- Summary
- 15/IA/3041
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/09/16
- Date To
- 31/08/20
- Title
- Investigating the link between IL8 haplotype and susceptibility to bacterial and viral infection in calves
- Summary
- 201603
- Funding Agency
- Teagasc
- Date From
- 01/10/16
- Date To
- 30/09/20
- Title
- Characterisation of Staphylococcal protein A - Bcell interactions to facilitate its development as a vaccine antigen
- Funding Agency
- GSK
- Date From
- 01/10/15
- Date To
- 30/09/19
- Title
- Characterisation of epithelial surface immunity to Staphylococcus aureus: Targeting IL-22
- Summary
- GOIPD/2014/385
- Funding Agency
- Irish Research Council
- Date From
- 01/10/14
- Date To
- 30/09/16
- Title
- Immunomodulation by the pathobiont Staphylococcus aureus: benefits for bug or host
- Summary
- CS/2014/1150/E
- Funding Agency
- Enterprise Ireland
- Date From
- 01/12/14
- Date To
- 31/12/15
- Title
- Understanding cellular immunity to Staphylococcus aureus is required for novel anti-S.aureus vaccine design
- Summary
- 12/IP/1532
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/04/13
- Date To
- 31/03/17
- Title
- Targeting cellular immunity; the future for Staphylococcus aureus vaccine design
- Summary
- HRA_POR/2012/104
- Funding Agency
- Health Research Board
- Date From
- 01/10/12
- Date To
- 30/09/15
- Title
- Comparative analysis of blood, milk and uterine neutrophil function in primiparous and multiparous Holstein-Friesian cows with divergent immunity genotypes
- Summary
- GO1535
- Funding Agency
- Teagasc
- Date From
- 01/10/11
- Date To
- 30/09/15
- Title
- Conference grant to support Staph GBI
- Summary
- 13/CW/B2624
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/08/13
- Date To
- 31/01/14
- Title
- Regulation of the neutrophil response by T-cell derived cytokines impacts upon Staphylococcus aureus infection outcomes (WT086515MA)
- Summary
- This proposal investigates how T-cells activated in the context of acute S.aureus infection can modulate the local neutrophil response. A clinically relevant murine model of S. aureus wound infection will be employed in conjunction with knockout mice to establish if specific T-cell phenotypes present at sites of S.aureus infection and the cytokines they produce can control neutrophil trafficking, activation and survival. The major focus of this grant is the neutrophil response during S.aureus infection. In particular it will investigate the controversial concept that S.aureus can exploit the neutrophil response and survive intra-cellular within the neutrophil. The conditions that favor this phenomena and the mechanism involved will be determined e.g. rate of neutrophil apoptosis/necrosis, phagocytic activity, and authophagy. In particular we will investigate if T-cell derived cytokines can modulate these phenomena.
- Funding Agency
- Wellcome Trust
- Date From
- 17/01/10
- Date To
- 16/01/15
- Title
- " A role for the immunomodulatory capsular polysaccharide Sp1 expressed by Streptococcus pneumoniae in the treatment of Asthma (PIRG06-GA-2009-256378)
- Summary
- This proposal will investigate the immunomodulatory properties of a capsular polysaccharide molecule expressed by the organism Streptococcus pneumoniae, which is commonly found to colonise the nasopharynx. This molecule has been shown to possess a unique chemical structure that confers upon it the ability to activate immunomodulatroy T-cells to produce the anti-inflammatory cytokine Interleukin-10. We will now investigate the ability of this polysaccharide to induce IL-10 production and protect against experimental asthma.
- Funding Agency
- European Commission
- Date From
- 01/10/10
- Date To
- 30/9/14
Recognition
Representations
Member of the Welcome Immune System in Health and Disease Expert Review Group
Associate editor PLOS Pathogens.
Editorial board member Infection and Immunity
Awards and Honours
Elected to Fellowship Trinity College Dublin
Memberships
International Cytokine Society
British Society Immunology
American Association of Immunology
Infectious Diseases Society of America
American Association of Microbiology