Scientists pinpoint potential new target for regulating inflammation
6 May 2019
Scientists from Trinity have discovered a potential new target for regulating inflammation, which drives a range of diseases including diabetes, cancer and Alzheimer’s.
The potential target is an ancient immune protein – SARM – that has been conserved throughout evolution and thus is very similar in humans, other mammals, flies and worms.
The work, which was funded by Science Foundation Ireland, was conducted by scientists in Professor Andrew Bowie’s research group, in particular co-first authors Dr Michael Carty and Dr Jay Kearney. Other scientists involved include Professors Ed Lavelle and Padraic Fallon (TBSI).
Their work has been published in the prestigious journal Immunity: https://www.cell.com/immunity/fulltext/S1074-7613(19)30185-2