Jhaleh Amirian

Affiliation(s):
Trinity College Dublin;

Department:
Obstetrics and Gynaecology

Research interests:
Thrombosis, gynaecological cancer, coagulation, hormones, pregnancy

PubMed Profile
https://pubmed.ncbi.nlm.nih.gov/?term=Jhaleh+Amirian

ORCID Profile
https://orcid.org/0000-0002-8504-6707

Biography

Dr Jhaleh Amirian is a Research Fellow in Biomedical Engineering at Trinity College Dublin, working at the interface of biomaterials, tissue engineering, regenerative medicine, and medical device development.

She has a multidisciplinary background in biomaterials engineering and has more than eight years of post-PhD research experience in the design and characterisation of advanced biomaterials for soft-tissue repair and regeneration. Her research combines material design, mechanical characterisation, tissue biomechanics, and translational medical device development.

Her current work includes the development of biomimetic and regenerative materials for pelvic-floor applications, with a particular focus on stress urinary incontinence and the development of next-generation alternatives to permanent synthetic mesh. She is currently contributing to the Smart-Sling programme, which aims to develop an adjustable and biologically compatible sling platform with improved mechanical performance and tissue integration.

Her broader research interests include understanding how material mechanics, degradation, tissue biomechanics, and biological responses can be integrated to develop patient-specific regenerative therapies. She also has experience in designing mechanically representative soft-tissue models for medical device testing and in collaborating with clinical, academic, patient and industry partners.

She brings to the Centre expertise in biomaterials, regenerative medicine, biomechanics and translational engineering, with a strong interest in developing new technologies for women’s health and pelvic-floor disorders.

Publications

1. Amirian J, Wychowaniec JK, D’Este M, Vernengo AJ, Metlova A, Sizovs A, Brangule A, Bandere D. Preparation and Characterization of Photo-Cross-Linkable Methacrylated Silk Fibroin and Methacrylated Hyaluronic Acid Composite Hydrogels. Biomacromolecules. 2024;25(11):7078–7097.
    https://doi.org/10.1021/acs.biomac.4c00319

2. Amirian J, Wychowaniec JK, Amel Zendehdel E, Sharma G, Brangule A, Bandere D. Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications. Biomacromolecules. 2023;24(7):2957–2981.
    https://doi.org/10.1021/acs.biomac.3c00098

3. Amirian J, Tran Thi Tuong Van, Bae SH, Jung HI, Choi HJ, Cho HD, Lee BT. Examination of In Vitro and In Vivo Biocompatibility of Alginate–Hyaluronic Acid Microbeads as a Promising Method in Cell Delivery for Kidney Regeneration. International Journal of Biological Macromolecules. 2017;105:143–153.
    https://doi.org/10.1016/j.ijbiomac.2017.07.019

4. Amirian J, Sultana T, Joo GJ, Park C, Lee BT. In Vitro Endothelial Differentiation Evaluation on Polycaprolactone–Methoxy Polyethylene Glycol Electrospun Membrane and Fabrication of Multilayered Small-Diameter Hybrid Vascular Graft. Journal of Biomaterials Applications. 2020;34(10):1395–1408.
    https://doi.org/10.1177/0885328220907775

5. Amirian J, Lee SY, Lee BT. Designing of Combined Nano and Microfiber Network by Immobilization of Oxidized Cellulose Nanofiber on Polycaprolactone Fibrous Scaffold. Journal of Biomedical Nanotechnology. 2016;12(10):1864–1875.
    https://doi.org/10.1166/jbn.2016.2308