Veronica Campbell
Bursar/Director of Strategic Initiative, Provost's Office
Professor, Trinity Inst. of Neurosciences (TCIN)
Professor, Physiology

Biography

Dr Campbell is a Pharmacology graduate (1991; University of Edinburgh) and was awarded her PhD in Neuropharmacology in 1995 (University of London). She took up an HRB post-doctoral fellowship in 1996, and was appointed to the Department of Physiology TCD in 1998.

Publications and Further Research Outputs

Peer-Reviewed Publications

Xue, F. Lennon, A.B. McKayed, K.K. Campbell, V.A. Prendergast, P.J., Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells, Computer Methods in Biomechanics and Biomedical Engineering, 18, (5), 2015, p468 - 476 Journal Article, 2015 URL DOI TARA - Full Text

Endocannabinoids and Alzheimer's Disease in, editor(s)Liana Fattore , Cannabinoids in Neurologic and Mental Disease, Elsevier Academic Press, 2015, ppChapter 2 - [SG Fagan, VA Campbell] Book Chapter, 2015

Fagan SG, Campbell VA., The influence of cannabinoids on generic traits of neurodegeneration, British Journal of Pharmacology, 171, (6), 2014, p1347 - 1360 Journal Article, 2014

Gowran A, McKayed K, Campbell VA, The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health., Stem cells international, 2013, 2013, p796715 Journal Article, 2013 DOI TARA - Full Text

Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA, The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-ß and in the cortex of aged rats., The Journal of biological chemistry, 287, (41), 2012, p34709-21 Journal Article, 2012 DOI

Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation., Journal of neuroinflammation, 9, 2012, p79 Journal Article, 2012 DOI TARA - Full Text

Tanveer R, Gowran A, Noonan J, Keating SE, Bowie AG, Campbell VA, The endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged rats., Journal of Biological Chemistry, 287(41), (41), 2012, p34709 - 34721 Journal Article, 2012 DOI

Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation, Journal of Neuroinflammation, 9, (79), 2012 Journal Article, 2012 DOI

Gowran, A., Murphy, C.E., Campbell, V.A., Corrigendum to "Δ9-Tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain" [FEBS Lett. 583 (2009) 3412-3418] (DOI:10.1016/j.febslet.2009.09.056), 2010, - 239 Miscellaneous, 2010 DOI

Campbell VA, O'Connell B, Cellular and molecular biomechanics., Technology and health care , 18, (3), 2010, p233-243 Journal Article, 2010 DOI

Fogarty, M.P., McCormack, R.M., Noonan, J., Murphy, D., Gowran, A., Campbell, V.A. , A role for p53 in the â-amyloid-mediated regulation of the lysosomal system , Neurobiology of Aging , 31, (10), 2010, p1774-1786 Journal Article, 2010 DOI

Cellular & Molecular Biomechanics. in, editor(s)T. Clive Lee, Peter F. Niederer , Engineering for Medics and Biologists - An ESEM Primer: Studies in health technology and informatics, Online, IOP Press Online, 2010, pp202-213 , [Campbell VA, O'Connell B] Book Chapter, 2010 URL

Noonan J, Tanveer R, Klompas A, Gowran A, McKiernan J, Campbell VA., Endocannabinoids prevent β-amyloid-mediated lysosomal destabilization in cultured neurons., Journal of Biological Chemistry, 285, (49), 2010, p38543 - 38554 Journal Article, 2010 DOI

Thorpe, S. D., Buckley, C. T., Vinardel, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , The response of bone marrow derived mesenchymal stem cells to dynamic compression following TGF-â3 induced chondrogenic differentiation, Annals of Biomedical Engineering , 38, (9), 2010, p2896-2909 Journal Article, 2010 DOI

Downer, EJ & Campbell VA, Phytocannabinoids, CNS cells and development; a dead issue?, Drug & Alcohol Review, 29, (1), 2010, p91 - 98 Journal Article, 2010 DOI

Aoife Gowran, Katey McKayed, Manoj Kanichai, Cillian White, Nissrin Hammadi and Veronica Campbell, Tissue Engineering of Cartilage; Can Cannabinoids Help?, Pharmaceuticals, 3, (9), 2010, p2970-2985 Journal Article, 2010 TARA - Full Text

Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic Compression Post TGF-â3 Induced Differentiation Augments Chondrogenesis of Mesenchymal Stem Cells., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010 Poster, 2010

Kearney EM, Farrell E, Prendergast PJ, Campbell VA, Tensile strain as a regulator of mesenchymal stem cell osteogenesis., Annals of Biomedical Engineering, 38, (5), 2010, p1767-1779 Journal Article, 2010 DOI

Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic compression of mesenchymal stem cells following cytokine induced differentiation augments glycosaminoglycan synthesis., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April, 2010 Poster, 2010

Fogarty MP, McCormack, RM, Noonan J, Murphy D, Gowran A, Campbell VA, A role for p53 in the ß-amyloid-mediated regulation of the lysosomal system, Neurobiology of Ageing, 583, (21), 2009, p3412-3418 Journal Article, 2009 DOI

McMahon, L.A., Campbell, V.A., Prendergast, P.J., Involvement of stretch-activated ion channels in strain-regulated glycosaminoglycan synthesis in mesenchymal stem cell-seeded 3D scaffolds , Journal of Biomechanics, 41, (9), 2008, p2055-2059 Journal Article, 2008 DOI

J.G. McGarry, P. Maguire, P.J. Prendergast, V.A. Campbell, B.C. O'Connell and S.P. Jarvis, Stimulating Nitric Oxide response in single osteoblasts using atomic force microscopy', Journal of Orthopaedic Research, 26, (4), 2008, p513-520 Journal Article, 2008 DOI URL

Cannabinoids and Neuroprotection in, editor(s)Attila Kofalvi , Cannabinoids and the Brain, Springer, 2008, pp317 - 330, [Veronica Campbell, Eric Downer] Book Chapter, 2008

Thorpe, S. D., Buckley, C. T., Vinardell, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 337, (2), 2008, p458-462 Journal Article, 2008 TARA - Full Text DOI URL

McMahon, L.A. , Prendergast, P.J. , Campbell, V.A., A comparison of the involvement of p38, ERK1/2 and PI3K in growth factor-induced chondrogenic differentiation of mesenchymal stem cells, Biochemical and Biophysical Research Communications , 368, (4), 2008, p990 - 995 Journal Article, 2008 DOI URL

Gowran A, Campbell VA., A role for p53 in the regulation of lysosomal permeability by Delta(9)-tetrahydrocannabinol in rat cortical neurones; implications for neurodegeneration., Journal of Neurochemistry, 105, (4), 2008, p1513 - 1524 Journal Article, 2008 DOI

Byrne, E.M., Farrell, E., McMahon, L.A., Haugh, M.G., O'Brien, F.J., Campbell, V.A., Prendergast, P.J., O'Connell, B.C., Gene expression by marrow stromal cells in a porous collagen- glycosaminoglycan scaffold is affected by pore size and mechanical stimulation , Journal of Materials Science: Materials in Medicine, 19, (11-12), 2008, p3455-3463 Journal Article, 2008 DOI

Kearney M, Prendergast PJ, Campbell VA, Mechanisms of strain-mediated mesenchymal stem cell apoptosis, Journal of Biomechanical Engineering, 130, (6), 2008, pArticle number 061004 Journal Article, 2008 DOI

McMahon, L.A., Reid, A.J., Campbell, V.A. & Prendergast, P.J. , Regulatory Effects of Mechanical Strain on the Chondrogenic Differentiation of MSCs in a Collagen-GAG Scaffold: Experimental and Computational Analysis , Annals of Biomedical Engineering, 36, (2), 2008, p185-194 Journal Article, 2008 URL DOI

Kanichai M, Ferguson D, Prendergast PJ, Campbell VA, Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxia-inducible factor (HIF)-1, Journal of Cellular Physiology, 216, (3), 2008, p708 - 715 Journal Article, 2008 DOI

McGarry, JG, Maguire, P, Prendergast, PJ, Campbell, VA, O'Connell, BC, Jarvis, SP, Stimulation of nitric oxide mechanotransduction in single osteoblasts using atomic force microscopy, Journal of Orthopaedic Research, 26, (4), 2008, p513 - 521 Journal Article, 2008 DOI URL

Downer EJ, Gowran A, Campbell VA., A comparison of the apoptotic effect of Delta(9)-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex., Brain Research, 1175, (1), 2007, p39 - 47 Journal Article, 2007 DOI

Farrell, E, Byrne, EM, Fischer, J, O'Brien, FJ, O'Connell, BC, Prendergast, PJ, Campbell, VA, A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds., Technology and Healthcare, 15, (1), 2007, p19 - 31 Journal Article, 2007 URL TARA - Full Text

Downer EJ, Gowran A, Murphy AC, Campbell VA., The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Delta(9)-tetrahydrocannabinol in cultured cortical neurons, European Journal of Pharmacology , 564, (1-3), 2007, p57 - 65 Journal Article, 2007 DOI

Campbell VA, Gowran A., Alzheimer's disease; taking the edge off with cannabinoids?, British Journal Pharmacology, 152, (5), 2007, p655 - 662 Journal Article, 2007 DOI

Maguire P, Kilpatrick JI, Kelly G, Prendergast PJ, Campbell VA, O'Connell BC, Jarvis SP, Direct mechanical measurement of geodesic structures in rat meseenchymal stem cells, Human Frontiers Science Program Journal, 1, (3), 2007, p181 - 191 Journal Article, 2007 DOI URL

P. Maguire, J.I. Kilpatrick, G. Kelly, P.J. Prendergast, V.A. Campbell, B.C. O'Connell and S.P. Jarvis, Direct mechanical measurement of geodesic structures in rat mesenchymal stem cells', Human Frontiers Science Program Journal, 1, (3), 2007, 181-191 Journal Article, 2007 URL DOI

Gowran AM, Campbell VA, Molecular mechanisms of cannabinoid-induced neurotoxicity in rat cortical neurons, European Neuropsychopharmacology, 16, (Suppl. 1), 2006, pS26 - S27 Journal Article, 2006

Prendergast, P.J., Kelly, D.J., McMahon, L.A., Campbell, V.A. , A computational optimization of scaffolds for tissue engineering of cartilage., Tissue Engineering, Abstracts of 8th TESI Annual Meeting 2005, Shanghai, China, October 22-25, 12, 2006, pp1024 Meeting Abstract, 2006

Prina-Mello A, Farrell E, Prendergast PJ, Campbell V, Coey JMD , Influence of strong static magnetic fields on primary cortical neurons , Bioelectromechanics, 27, 1, (Jan), 2006, p35 - 42 Journal Article, 2006

Prendergast PJ, Kelly DJ, McMahon LA, Campbell VA, A computational optimisation of scaffolds for tissue engineering of cartilage, Tissue Engineering, 12, (4), 2006, p1024 - 1024 Journal Article, 2006 DOI

E. Farrell., F.J. O'Brien., P. Doyle., J. Fischer., I. Yannas., B. O'Connell., P.J. Prendergast & V.A. Campbell , A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes., Tissue Engineering, 12, (3), 2006, p459 - 468 Journal Article, 2006 URL DOI

Prina-Mello A., Farrell E., Prendergast P.J., Campbell V., Coey J.M.D. , Influence of Strong Static Magnetic Fields on Primary Cortical Neurons, Bioelectromagnetics, 27, (1), 2006, p35 - 42 Journal Article, 2006 DOI URL

Prina_Mello, A, Farrell, E, Prendergast, PJ, Campbell, V, Coey, JMD, Effects of static magnetic fields on Primary cortical neurons, Physica Scripta, T118, 2005, p205 - 207 Journal Article, 2005 DOI URL

Nolan Y, Campbell VA, Bolton AE, Lynch MA, Evidence of an anti-inflammatory role for Vasogen's immune modulation therapy, Neuroimmunomodulation, 12, (2), 2005, p113 - 116 Journal Article, 2005 DOI URL

Prina_Mello A. , Campbell V., and Coey J.M.D. , Static magnetic field effect in cells. A possible roa to cell differentiation., NSTI Nanotech 2005 , Anaheim, CA, May 2005, edited by NSTI , NSTI, 2005 Conference Paper, 2005

Lynch AM, Walsh C, Delaney A, Nolan Y, Campbell VA, Lynch MA , Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?, Journal of Neurochemistry, 88, (3), 2004, p635 - 646 Journal Article, 2004 URL DOI

Boland, B. and Campbell, V. , Aß-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L., Neurobiology of Aging , 25, (1), 2004, p83 - 91 Journal Article, 2004 DOI

Farrell, E., O'Brien, F., Prendergast, P. J., Campbell, V. A., Mesenchymal stem cells and bioengineering, Journal of Anatomy, 205, (6), 2004, p504 - 536 Journal Article, 2004 URL

Nolan, Y., Martin, D.S.D., Campbell, V.A., and Lynch, M.A., Evidence of a protective effect of phosphatidylserine on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus, J. Neuroimmunol., 151, (Issues 1-2,), 2004, p12-23 Journal Article, 2004 DOI URL

McCormack, R. M., Fogarty, M. P., Campbell, V. A., Beta-amyloid modulates the lysosomal system in rat cortical neurons in vitro in a p53-dependent manner, Journal of Anatomy, 205, (6), 2004, p531-532 Journal Article, 2004 URL

Scaffolds and cells: preliminary biomechanical analysis and results for the use of a collagen-GAG scaffold for bone tissue engineering in, editor(s)P.J Prendergast & P.E McHugh , Topics in Bio-Mechanical Engineering, Dublin, TCBE & NCBES, 2004, pp167 - 183, [F.J. O'Brien, E. Farrell, M.A. Waller, I. Connell, D. O'Mahoney, J.P. McGarry, B.P. Murphy, P.E. McHugh, V.A. Campbell, P.J. Prendergast ] Book Chapter, 2004

Marie P. Fogarty, Eric J. Downer and Veronica Campbell, A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the b-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons, Biochemical Journal, 371, 2003, p789-798 Journal Article, 2003 DOI

Fogarty, M.P., Downer, E. and Campbell, V. , Characterisation of the role of JNK isoforms in ß-amyloid-mediated p53 activation and apoptosis. , Biochemical Journal , 371, 2003, p779 - 789 Journal Article, 2003

Boland, B and Campbell, V, beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase., Neurobiology of Aging , 24, (1), 2003, p179 - 186 Journal Article, 2003 URL

Downer E., Fogarty M.P. and Campbell, V.A , Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons , British Journal of Pharmacology , 140, (3), 2003, p547 - 557 Journal Article, 2003 URL

Minogue, A.M., Schmid, A.W., Fogarty, M.F., Moore, A.C., Campbell, V.A. and Herron, C.E., Activation of the JNK signalling cascade mediates the effect of A beta on LTP and cell death in hippocampus: a role for IL-1 beta, J. Biol. Chem., 278, (30), 2003, p27971 - 27980 Journal Article, 2003 URL DOI

Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch, Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's immune modulation therapy, Neuroimmunomodulation, 10, (1), 2002, p40 - 46 Journal Article, 2002 URL DOI

Darren S. D. Martin, Peter E. Lonergan, Barry Boland, Marie P. Fogarty, Marcella Brady, David F. Horrobin, Veronica A. Campbell, and Marina A. Lynch, Apoptotic changes in the aged brain are triggered by interleukin-1 beta-induced activation of P38 and reversed by treatment with eicosapentaenoic acid, Journal of Biological Chemistry, 277, (37), 2002, p34239 - 34246 Journal Article, 2002 DOI URL

Campbell, V.A., Tetrahydrocannabinol-induced apoptosis in cultured cortical neurons is associated with cytochrome c release and caspase-3 activation, Neuropharmacology , 40, (5), 2001, p702 - 709 Journal Article, 2001 URL DOI

Veronica Campbell and Marina A. Lynch , The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1beta in rat cortical synaptosomes, Cytokine, 12, (5), 2000, p487 - 490 Journal Article, 2000 URL DOI

Campbell, V., Beddy, P., Foley, A., Bakhle, Y.S. and Bell, C, Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK1 receptor number. , European Journal of Pharmacology , 401, (1), 2000, p109 - 114 Journal Article, 2000 DOI

Campbell, V. and Lynch, M.A , The role of ceramide in the interleukin-1ß-mediated modulation of [Ca2+]i in rat cortical synaptosomes., Cytokine, 12, (5), 2000, p487 - 490 Journal Article, 2000 DOI

MacManus A., Ramsden, M., Murray M., Pearson H.A and Campbell V , ) Enhancement of 45Ca2+ influx and voltage-dependent Ca2+ channel activity by ß-amyloid(1-40) in rat cortical synaptosomes and cultured cortical neurones: modulation by the proinflammatory cytokine interleukin-1ß, Journal of Biological Chemistry , 275, 2000, p4713 - 4718 Journal Article, 2000 URL

Vereker E, Campbell V, Roche E, McEntee E, Lynch MA., Lipoplysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1, Journal of Biological Chemistry, 275, (34), 2000, p26252 - 26258 Journal Article, 2000 URL DOI

Campbell, Veronica; Lynch, Marina A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1[beta] in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, NEUROREPORT, 9, (9), 1998, p1923 - 1927 Journal Article, 1998 URL

Campbell, V. and Lynch, M.A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1ß in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, Neuroreport , 9, (9), 1998, p1923 - 1927 Journal Article, 1998 URL

V. A. Campbell, R. Segurado and M. A. Lynch, Regulation of intracellular Ca2+ concentration by interleukin-1â in rat cortical synaptosomes: an age-related study , Neurobiology of Aging, 19, (6), 1998, p575 - 579 Journal Article, 1998 DOI URL

Brice, N.L., Berrow, N.S., Campbell, V., Page, K.M., Tedder, I. and Dolphin, A.C , Importance of the different beta subunits in the membrane expression of the alpha1A and alpha2 calcium channel subunits: studies using a depolarization-sensitive alpha1A antibody., European Journal of Neuroscience , 9, (4), 1997, p749 - 759 Journal Article, 1997

Wyatt, C.N., Campbell, V., Page, K.M., Berrow, N.S., Terracciano, C.M., Naqvi, N., MacLeod, K.T. and Dolphin A.C, Voltage-dependent binding and calcium channel current inhibition by an anti-?1D subunit antibody in rat dorsal root ganglion neurones and guinea-pig myocytes, Journal of Physiology, 502, (2), 1997, p307 - 320 Journal Article, 1997 DOI

Campbell, V., Berrow, N.S., Brickley, K,. Page, K.M., Wade, R. and Dolphin, A.C , Voltage-dependent calcium channel ß-subunits, in combination with ?1-subunits, have a GTPase activating effect to promote the hydrolysis of GTP by G?o in rat frontal cortex., FEBS Letters , 370, (1-2), 1995, p135 - 140 Journal Article, 1995 DOI

Campbell, V., Berrow, N.S., Fitzgerald, E., Brickley, K. and Dolphin, A., Inhibition of the interaction of G protein Go with calcium channels by the calcium channel ß-subunit in rat sensory neurones., Journal of Physiology , 485, (2), 1995, p365 - 372 Journal Article, 1995 DOI

Berrow, N.S., Campbell, V., Fitzgerald, E.M., Brickley, K. and Dolphin, A.C , Antisense depletion of the ß-subunits modulates the biophysical and pharmacological properties of neuronal calcium channels., Journal of Physiology , 482, (3), 1995, p481 - 491 Journal Article, 1995 URL

Brickley, K., Campbell, V., Berrow, N., Leach, R., Norman, R.I., Wray, D. and Dolphin, A.C. , Use of site-directed antibodies to probe the topology of the ?2-subunit of the voltage-dependent Ca2+ channel. , FEBS Letters , 364, (2), 1995, p129 - 133 Journal Article, 1995 DOI

Modulation of voltage-dependent calcium channels by GABA receptors and G-proteins in cultured rat dorsal root ganglion neurons: relevance to transmitter release and its modulation. in, editor(s)Urban, L , Cellular Mechanisms of Sensory Transmission, Berlin, Springer-Verlag, 1994, pp47 - 61, [Dolphin, A.C., Menon-Johansson, A. Campbell, V., Berrow, N.and Sweeney, M.I ] Book Chapter, 1994

Pearson, H.A., Campbell, V., Berrow, N., Menon-Johansson, A. and Dolphin, A.C., Modulation of voltage dependent calcium channels in cultured neurons, Annals of the New York Academy of Sciences, 747, 1994, p325 - 335 Journal Article, 1994

Campbell, V., Berrow, N. S. and Dolphin, A.C., GABAB receptor modulation of Ca2+ currents in rat sensory neurones by the G protein Go: antisense oligonucleotide studies, Journal of Physiology , 470, 1993, p1 - 11 Journal Article, 1993 URL

Anderson, D.G., Campbell, V.A., Forsyth, G.A., Rankin, D.W.H., Determination of the molecular structures of bis(methylsilyl) sulphide and bis(dimethylsilyl) sulphide in the gas phase by electron diffraction, supported by molecular mechanics calculations, Journal of the Chemical Society, Dalton Transactions, 7, 1990, p2125-2130 Journal Article, 1990 DOI

Research Expertise

Description

Cannabinoid neuropharmacology; ß-amyloid; Neurodegeneration; Regulation of neuronal calcium homeostasis; Tissue engineering of bone and cartilage; Mesenchymal stem cells

Projects

  • Title
    • Do cannabinoids confer neuroprotection by stabilizing lysosomes?
  • Funding Agency
    • Health Research Board
  • Date From
    • 2009
  • Date To
    • 2011
  • Title
    • Cannabinoids and mesenchymal stem cell differentiation
  • Summary
    • The aim of this project is to examine the role of cannabinoid pathways in the control of bone and cartilage development.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • October 2007
  • Date To
    • September 2009
  • Title
    • Effect of hypoxia on tissue engineering of bone and cartilage
  • Summary
    • This interdisciplinary project aims to identify the optimal conditions for inducing differentiation of adult mesenchymal stem cells along the osteogenic and chondrogenic lineages. The study will identify the signal transduction pathways involved in these processes.
  • Funding Agency
    • Health Research Board
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Cannabinoids and neuronal fate
  • Summary
    • Marijuana is the most commonly used illegal drug of abuse in Ireland, particularly amongst the 14-16 year old age group. ?9-tetrahydrocannabinol (THC) is the psychoactive ingredient of marijuana and this project is concerned with furthering our understanding of the impact of THC on the brain.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2004
  • Date To
    • 2007
  • Title
    • Investigation into the role of lysosomes in neuronal cell death
  • Summary
    • Alzheimer's disease is a devastating neurodegenerative condition which is associated with cognitive decline and neuronal loss. A neuropathological hallmark of this disease is the deposition of ß-amyloid (Aß) protein around neurons, and Aß is thought to contribute to the disease process by inducing neuronal cell death. We have identified that Aß increases intracellular Ca2+ concentration in cortical neurons (MacManus et al., 2000), leading to activation of Ca2+-dependent proteases and subsequent cell death (Boland et al., 2003). Understanding how Aß influences intracellular Ca2+ homeostasis is one of our key research questions given that dysregulation of this ion provides the basis for the "calcium hypothesis of neurodegeneration". Lysosomes are relatively understudied organelles that serve as reservoirs for Ca2+. Our recent work has demonstrated that Aß impacts on the lysosomal system, causing lysosomes to become leaky and release lysosomal proteases which then contribute to the cell death cascade (Boland et al., 2004). Events which cause the lysosomal membrane to become leaky are likely to promote the release of lysosomal Ca2+, as well as proteolytic enzymes, and contribute to the increase in intracellular Ca2+ concentration which is associated with many forms of cell death. We are currently attempting to examine the influence of Aß on lysosomal Ca2+ homeostasis since this may contribute to the induction of apoptosis that we observe following exposure of neurons to Aß in vitro .
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2003
  • Date To
    • 2006

Keywords

Apoptosis; Biology; Biomedical sciences; Intra and intercellular signalling; Neurochemistry and neuropharmacology; Neurodegeneration; Neuropharmacology; Physiology

Recognition

Awards and Honours

Fellow of TCD 2004

Memberships

Secretary, Biomedical Sciences Section (Royal Academy Medicine in Ireland) 2004

Fellow, Royal Academy Medicine in Ireland

Member, Society for Neuroscience

Member, Physiological Society

Editor, British Journal of Pharmacology 2005