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Professor Jacintha O'Sullivan
Professor Of, Surgery

Publications and Further Research Outputs

Peer-Reviewed Publications

Fiona O"Connell, Eimear Mylod, Noel E. Donlon, Maria Davern, Christine Butler, Niamh O"Connor, Meghana Menon, Claire L. Donohoe, Narayanasamy Ravi, Derek G. Doherty, Margaret R. Dunne, John V. Reynolds, Helen M. Roche, Jacintha O"Sullivan, Adipose tissue from oesophageal adenocarcinoma patients is differentially affected by chemotherapy and chemoradiotherapy regimens altering immune cell phenotype and cancer cell metabolism, Translational Oncology, 53, 2025, p102302 - 102302, p102302-102302 Journal Article, 2025 DOI

Tao Zhang, Kit Chan, Abdulilah ECE, Robin Daly, Aoife Cannon, Neil Frankish, Jacintha O'Sullivan, Padraig Fallon, Helen Sheridan, Bioactive Indanes: Design, Synthesis and Bioactivity Investigation of 2,2-Substituted Indane Derivatives, a New Bioactive Indane Scaffold, Bioorganic Chemistry, 2025 Journal Article, 2025

R Corcoran, Finbarr O"Connell, N Schellenberg, Jacintha O"Sullivan, David Kevans, P0084 Secreted inflammatory protein profiles of human inflammatory bowel disease explants following treatment ex-vivo with licenced biologic therapies and patients" in-vivo response, Journal of Crohn s and Colitis, 19, (Supplement_1), 2025, pi449 - i449, pi449-i449 Journal Article, 2025 DOI

Sharma, S., Carey, N., McConnell, D. Lowery, M., O'Sulliavan, J., McCullagh, L. for the HEALED Consortium, Systematic Review of Economic Evaluations of Systemic Treatments for Advanced and Metastatic Gastric Cancer, PharmacoEconomics, 2024 Journal Article, 2024

Bennett, A.E., O'Neill, L., Doyle, S.L., Guinan, E.M., O'Sullivan, J., Reynolds, J.V., Hussey, J., Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery, Nutrition and Cancer, 2024, p1-10 Journal Article, 2024 DOI URL

O†Sullivan, Niall J. and Temperley, Hugo C. and Kyle, Eimear T. and Sweeney, Kevin J. and O†Neill, Maeve and Gilham, Charles and O†Sullivan, Jacintha and O†Kane, Grainne and Mehigan, Brian and O†Toole, Sharon and Larkin, John and Gallagher, David and McCormick, Paul and Kelly, Michael E., Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis, International Journal of Colorectal Disease, 39, (1), 2024 Journal Article, 2024 DOI

Kathleen A. J. Mitchelson, Fiona O"Connell, Jacintha O"Sullivan, Helen M. Roche, Obesity, Dietary Fats, and Gastrointestinal Cancer Risk-Potential Mechanisms Relating to Lipid Metabolism and Inflammation, Metabolites, 14, (1), 2024, p42 - 42, p42-42 Journal Article, 2024 DOI

C McShane, Fiona O"Connell, R Corcoran, Croí E. Buckley, Niamh Lynam"Lennon, David Kevans, Jacintha O"Sullivan, P066 Serum amyloid A " A Novel Biomarker of Ulcerative Colitis Disease Activity, Journal of Crohn s and Colitis, 18, (Supplement_1), 2024, pi336 - i336, pi336-i336 Journal Article, 2024 DOI

Murphy DM, Walsh A, Stein L, Petrasca A, Cox DJ, Brown K, Duffin E, Jameson G, Connolly SA, O'Connell F, O'Sullivan J, Basdeo SA, Keane J, Phelan JJ., Human Macrophages Activate Bystander Neutrophils' Metabolism and Effector Functions When Challenged with Mycobacterium tuberculosis., International journal of molecular sciences, 25, (5), 2024, p2898 Journal Article, 2024 DOI

Laura Kane, Brian Flood, Joan Manils, Donna E McSkeane, Aoife P. Smith, Miriam Tosetto, Fatema Alalawi, Joanna Fay, Elaine W. Kay, Cara Dunne, Stephen McQuaid, Maurice B. Loughrey, Jacintha O"Sullivan, Elizabeth J. Ryan, Kieran Sheahan, Glen Doherty, Emma M. Creagh, Caspase-4 has potential utility as a colorectal tissue biomarker for dysplasia and early-stage cancer, Gastro Hep Advances, 4, (2), 2024, p100552 - 100552, p100552-100552 Journal Article, 2024 DOI

O'Brien, R.M. and Meltzer, S. and Buckley, C.E. and Heeran, A.B. and Nugent, T.S. and Donlon, N.E. and Reynolds, J.V. and Ree, A.H. and Redalen, K.R. and Hafeez, A. and O'Ríordáin, D.S. and Hannon, R.A. and Neary, P. and Kalbassi, R. and Mehigan, B.J. and McCormick, P.H. and Dunne, C. and Kelly, M.E. and Larkin, J.O. and O'Sullivan, J. and Lysaght, J. and Lynam-Lennon, N., Complement is increased in treatment resistant rectal cancer and modulates radioresistance, Cancer Letters, 604, (217253), 2024 Journal Article, 2024 DOI

Simone Marcone, Jolanda Spadavecchia, Memona Khan, Gabriele Vella, Fiona O"Connell, Marzia Pendino, Meghana Menon, Claire Donohoe, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Niamh Lynam"Lennon, Breandán N. Kennedy, Adriele Prina"Mello, Jacintha O"Sullivan, Targeting Radiation Resistance in Oesophageal Adenocarcinoma with Pyrazinib-Functionalised Gold Nanoparticles, Cancers, 16, (23), 2024, p4007 - 4007, p4007-4007 Journal Article, 2024 DOI

Maitiú Ó Murchú, Xuehua Lin, Melissa Anne Tutty, Christina Cahill, Ian S. Miller, Lasse Jensen, Adriele Prina"Mello, Niamh Lynam"Lennon, Stephen G. Maher, Helena Kelly, Jacintha O"Sullivan, Enhancing cancer radiotherapy efficacy using NanOx, a novel oxygenating perfluorocarbon nanoemulsion that reverses tumour hypoxia., Cancer Letters, 2024, p217406 - 217406, p217406-217406 Journal Article, 2024 DOI

Husvinee Sundaramurthi, Valentina Tonelotto, Kieran Wynne, Fiona O"Connell, Eve O"Reilly, Marcel Costa-García, Csenger Kovácsházi, Ágnes Kittel, Simone Marcone, Alfonso Blanco, Éva Pállinger, Szabolcs Hambalkó, J.M. Piulats Rodriguez, Péter Ferdinandy, Jacintha O"Sullivan, David Matallanas, Lasse D. Jensen, Zoltán Giricz, Breandán N. Kennedy, Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes, Open Research Europe, 3, 2023, p88 - 88, p88-88 Journal Article, 2023 DOI

Croí E. Buckley, Xiaofei Yin, Sebastian Meltzer, Anne Hansen Ree, Kathrine Røe Redalen, Lorraine Brennan, Jacintha O"Sullivan, Niamh Lynam"Lennon, Energy Metabolism Is Altered in Radioresistant Rectal Cancer, International Journal of Molecular Sciences, 24, (8), 2023, p7082 - 7082, p7082-7082 Journal Article, 2023 DOI

Moran J, Mylod E, Kane LE, Marion C, Keenan E, Mekhaeil M, Lysaght J, Dev KK, O'Sullivan J, Conroy MJ., Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses, Pharmaceutics, 2023 Journal Article, 2023 DOI TARA - Full Text

O†Connell, F. and Mylod, E. and Donlon, N.E. and Heeran, A.B. and Butler, C. and Bhardwaj, A. and Ramjit, S. and Durand, M. and Lambe, G. and Tansey, P. and Welartne, I. and Sheahan, K.P. and Yin, X. and Donohoe, C.L. and Ravi, N. and Dunne, M.R. and Brennan, L. and Reynolds, J.V. and Roche, H.M. and O†Sullivan, J., Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients with Oesophageal Adenocarcinoma, Cancers, 15, (6), 2023 Journal Article, 2023 DOI

Sarah Elizabeth Lochrin, Oana Deac, Jacintha O"Sullivan, Moya Cunningham, Narayanasamy Ravi, Claire Donohoe, Grainne M. O"Kane, John V. Reynolds, Maeve A. Lowery, Clinicopathologic features of early-onset (EO) esophageal and gastric cancers., Journal of Clinical Oncology, 41, (4_suppl), 2023, p472 - 472, p472-472 Journal Article, 2023 DOI

Buckley, C.E. and O†Brien, R.M. and Nugent, T.S. and Donlon, N.E. and O†Connell, F. and Reynolds, J.V. and Hafeez, A. and O†Ríordáin, D.S. and Hannon, R.A. and Neary, P. and Kalbassi, R. and Mehigan, B.J. and McCormick, P.H. and Dunne, C. and Kelly, M.E. and Larkin, J.O. and O†Sullivan, J. and Lynam-Lennon, N., Metformin is a metabolic modulator and radiosensitiser in rectal cancer, Frontiers in Oncology, 13, (1216911), 2023 Journal Article, 2023 DOI

Kimberly A. Luddy, Jeffery West, Mark Robertson"Tessi, Bina Desai, Taylor M. Bursell, Sarah Barrett, Joel S. Brown, Jacintha O"Sullivan, Robert A. Gatenby, Laure Marignol, Alexander R.A. Anderson, Cliona O"Farrelly, Abstract 2858: Radiotherapy and NK cell-based immunotherapy: An evolutionary double-bind, Cancer Research, 83, (7_Supplement), 2023, p2858 - 2858, p2858-2858 Journal Article, 2023 DOI

Darragh O"Dowd, Jacintha O"Sullivan, Simone Marcone, Prognostic, Diagnostic and Predictive Biomarkers in the Barrett"s Oesophagus-Adenocarcinoma Disease Sequence, Cancers, 14, (14), 2022, p3427 - 3427, p3427-3427 Journal Article, 2022 DOI

R Corcoran, Finbarr O"Connell, Jacintha O"Sullivan, David Kevans, P078 Vedolizumab Treatment of ex-vivo Human Ulcerative Colitis (UC) Explants Results in Altered Inflammatory Protein Secretion Profiles, Journal of Crohn s and Colitis, 16, (Supplement_1), 2022, pi180 - i181, pi180-i181 Journal Article, 2022 DOI

J E A O'Connell, Finbarr O"Connell, Jacintha O"Sullivan, David Kevans, P102 Changes in serum immune protein profiles following vedolizumab therapy in Inflammatory Bowel Disease, Journal of Crohn s and Colitis, 16, (Supplement_1), 2022, pi198 - i199, pi198-i199 Journal Article, 2022 DOI

R Corcoran, Finbarr O"Connell, Jacintha O"Sullivan, David Kevans, P084 Secreted inflammatory protein profiles following treatment of ex-vivo human Ulcerative Colitis and Crohn"s Disease explants with licenced biologic therapies, Journal of Crohn s and Colitis, 16, (Supplement_1), 2022, pi184 - i184, pi184-i184 Journal Article, 2022 DOI

Guo, N. and Minas, G. and Synowsky, S.A. and Dunne, M.R. and Ahmed, H. and McShane, R. and Bhardwaj, A. and Donlon, N.E. and Lorton, C. and O'Sullivan, J. and Reynolds, J.V. and Caie, P.D. and Shirran, S.L. and Lynch, A.G. and Stewart, A.J. and Arya, S., Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS, Journal of Proteomics, 266, (104684), 2022 Journal Article, 2022 DOI

Brennan, L., Sadeghi, F., O'Neill, L., Guinan, E., Smyth, L. Sheill, G., Smyth, E., Doyle, S.L., Timon, C., Connolly, D., O'Sullivan, J., Reynolds, J.V., and Hussey, J., Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study, Cancers, 2022 Journal Article, 2022 DOI

Naimimohasses S, O'Gorman P, Wright C, Ni Fhloinn D, Holden D, Conlon N, Monaghan A, Kennedy M, Gormley J, Beddy P, Finn SP, Lysaght J, O'Sullivan J, Dunne MR, Norris S, Moore JB., Differential Effects of Dietary versus Exercise Intervention on Intrahepatic MAIT Cells and Histological Features of NAFLD, Nutrients, 14, (11), 2022, p2198 Journal Article, 2022 URL

Fiona O"Connell, Eimear Mylod, Ailsing B. Heeran, Noel E. Donlon, Maria Davern, Christine Butler, Anshul Bhardwaj, Claire L. Donohoe, Narayanasamy Ravi, John V. Renyolds, Margaret R. Dunne, Helen M. Roche, Jacintha O"Sullivan, Abstract 1990: Exploring the immune-metabolic mechanisms of adipose tissue in oesophageal adenocarcinoma, Cancer Research, 82, (12_Supplement), 2022, p1990 - 1990, p1990-1990 Journal Article, 2022 DOI

J E A O'Connell, Jayne Doherty, Amy M. Buckley, David Cormican, Cara Dunne, Karen Hartery, John O. Larkin, F MacCarthy, Paul McCormick, Susan McKiernan, Brian Mehigan, Cian Muldoon, Ciara Ryan, Jacintha O"Sullivan, David Kevans, Colonic oncostatin M expression evaluated by immunohistochemistry and infliximab therapy outcome in corticosteroid-refractory acute severe ulcerative colitis, Intestinal Research, 20, (3), 2022, p381 - 385, p381-385 Journal Article, 2022 DOI

Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O'Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O'Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds and Joanne Lysaght, The Impact of Esophageal Oncological Surgery on Perioperative Immune Function; Implications for Adjuvant Immune Checkpoint Inhibition, Frontiers in Immunology, 2022 Journal Article, 2022 URL

R Corcoran, P. MacDonagh, Fiona O"Connell, Maria E. Morrissey, Margaret R. Dunne, Ruth Argue, Jacintha O"Sullivan, David Kevans, Association Between Ex Vivo Human Ulcerative Colitis Explant Protein Secretion Profiles and Disease Behaviour, Digestive Diseases and Sciences, 67, (12), 2022, p5540 - 5550, p5540-5550 Journal Article, 2022 DOI

Maryam Mukhtar, Niall Ashfield, "udmila Vodi"ková, Veronika Vymetalková, Miroslav Levý, Václav Liška, Jan Br"ha, Petra Bendová, Jacintha O"Sullivan, Glen Doherty, Kieran Sheahan, Bláthnaid Nolan, Pavel Vodi"ka, David J. Hughes, The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case"Control Studies in Irish and Czech Populations, Nutrients, 14, (13), 2022, p2718 - 2718, p2718-2718 Journal Article, 2022 DOI

E. Flis, G. Barber, C. Nulty, B. Keogh, P. McGuirk, A. Anand, J. O'Sullivan, M. Quante, E.M. Creagh. , Identification of TLR2 signalling mechanisms which Contribute to Barrett's and Oesophageal Adenocarcinoma Disease Progression, Cancers (Basel) , 13, (9), 2021, p2065 - 2081 Journal Article, 2021 DOI

Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E., Boland, L., Doyle, S., O'Sullivan, J., Reynolds, J.V., Hussey, J., Perspectives of Esophageal Cancer Survivors on Diagnosis, Treatment, and Recovery., Cancers, 13, (1), 2021, p1-12 Journal Article, 2021 DOI URL

Kennedy, S.A., Annett, S.L., Dunne, M.R., Boland, F., O'Neill, L.M., Guinan, E.M., Doyle, S.L., Foley, E.K., Elliott, J.A., Murphy, C.F., Bennett, A.E., Carey, M., Hillary, D., Robson, T., Reynolds, J.V., Hussey, J., O'Sullivan, J.N., Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors, Frontiers in Oncology, 11, (669078), 2021, p1-11 Journal Article, 2021 DOI

G. Barber, A. Anand, K. Oficjalska, J.J. Phelan, A. B. Heeran, E. Flis, N. E. Clarke, J. A. Watson, J. Strangmann, B. Flood, H. O'Neill, D. O'Toole, F. MacCarthy, N. Ravi, J. V. Reynolds, E.W. Kay, M. Quante, J. O'Sullivan, E.M. Creagh., Characterizing caspase-1 involvement during esophageal disease progression. , Cancer Immunology Immunotherapy, 69, (12), 2020, p2635 - 2649 Journal Article, 2020 TARA - Full Text DOI

O'NEILL L., GUINAN E., DOYLE S., CONNOLLY D., O'SULLIVAN J., BENNETT A., SHEILL G., SEGURADO R., KNAPP P., FAIRMAN C., NORMAND C., GEOGHEGAN J., CONLON K., REYNOLDS JV., HUSSEY J., Rehabilitation strategies following oesophagogastric and hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomised controlled trial, BMC Cancer, 20, 2020, p1 - 20 Journal Article, 2020 DOI

O'Neill L., Guinan E., Doyle S., O'Connor L., Sheill G., Smyth E., Fairman C., Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol, HRB Open Research, 2020 Journal Article, 2020 DOI

Cannon, A. and Clarke, N. and MacCarthy, F. and Dunne, C. and Kevans, D. and Mahmud, N. and Lysaght, J. and O'Sullivan, J., Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue, JGH Open, 4, (6), 2020, p1191-1198 Journal Article, 2020 DOI TARA - Full Text

Azizah M. Malebari, Darren Fayne, Seema M. Nathwani, Fiona O'Connell, Sara Noorani, Brendan Twamley, Niamh M. O'Boyle, Jacintha O'Sullivan, Daniela M. Zisterer, Mary J. Meegan, Beta-lactams with antiproliferative and antiapoptotic activity in breast and chemoresistant colon cancer cells, European Journal of Medicinal Chemistry, 189, 2020, p112050- Journal Article, 2020 DOI URL

Buckley AM, Dunne MR, Morrissey ME, Kennedy SA, Nolan A, Davern M, Foley EK, Clarke N, Lysaght J, Ravi N, O'Toole D, MacCarthy F, Reynolds JV, Kennedy BN, O'Sullivan J., Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib., Scientific reports, 10, (1), 2020, p12105 Journal Article, 2020 DOI TARA - Full Text

Guinan, E.M., Bennett, A.E., Doyle, S.L., O'Neill, L, Gannon, J., Foley, G., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study, BMC Cancer, 19, (682), 2019 Journal Article, 2019 TARA - Full Text URL DOI

O'Neill L., Knapp P., Doyle SL., Guinan E., Parker A.,Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, 'Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT) [version 1; peer review: awaiting peer review]', 2019, - Protocol or guideline, 2019 DOI

Melo, Ashanty M., O'Brien, Aisling M., Phelan, James J., Kennedy, Susan A., Wood, Nicole A. W., Veerapen, Natacha, Besra, Gurdyal S., Clarke, Niamh E., Foley, Emma K., Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V., Conroy, Melissa J., Hogan, Andrew E., O'Sullivan, Jacintha, Dunne, Margaret R., Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma, Frontiers in Immunology, 10, 2019 Journal Article, 2019 TARA - Full Text DOI

Butler, C.T. and Kennedy, S.A. and Buckley, A. and Doyle, R. and Conroy, E. and Gallagher, W.M. and O'Sullivan, J. and Kennedy, B.N., 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours, Oncotarget, 10, (38), 2019, p3725-3744 Journal Article, 2019 DOI TARA - Full Text

Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J., Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma., Cancer letters, 447, 2019, p115-129 Journal Article, 2019 DOI

Guinan, E.M., Doyle, S.L., Bennett, A.E., O'Neill, L, Gannon, J., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Sarcopenia during neoadjuvant therapy for oesophageal cancer: characterising the impact on muscle strength and physical performance, Supportive Care in Cancer, 26, (5), 2018, p1569 - 1576 Journal Article, 2018 URL DOI

Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E.M., Boland, L., Doyle, S.L., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer, Supportive Care in Cancer, 26, (8), 2018, p2615 - 2623 Journal Article, 2018 DOI URL

Buckley AM, Lynam-Lennon N, Kennedy SA, Dunne MR, Aird JJ, Foley EK, Clarke N, Ravi N, O'Toole D, Reynolds JV, Kennedy BN, O'Sullivan J., Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma., Oncotarget, 9, (72), 2018, p33634-33647 Journal Article, 2018 TARA - Full Text DOI

James J. Phelan, Finbar MacCarthy, Dermot O'Toole, Narayanasamy Ravi, John V. Reynolds and Jacintha O'Sullivan, The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus, International Journal of Molecular Sciences, 19, (11), 2018 Journal Article, 2018 DOI URL TARA - Full Text

O'Neill, L.M., Guinan, E., Doyle, S.L., Bennett, A.E., Murphy, C., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., Hussey, J., The RESTORE Randomized Controlled Trial: Impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship, Annals of Surgery, 268, (5), 2018, p747 - 755 Journal Article, 2018 DOI URL

Sinead A. Noonan*, Maria E. Morrissey*, Petra Martin, Monika Biniecka, Shane Ó'Meachair, Aoife Maguire, Miriam Tosetto, Blathnaid Nolan, John Hyland, Kieran Sheahan, Diarmuid O'Donoghue, Hugh Mulcahy, David Fennelly, Jacintha O'Sullivan, Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment, Oncotarget, 9, 2018, p10536 - 10548 Journal Article, 2018 DOI URL TARA - Full Text

Donohoe C.L, Lysaght J, O'Sullivan J, Reynolds J.V, Emerging Concepts Linking Obesity with the Hallmarks of Cancer, Trends in Endocrinology and Metabolism, 28, (1), 2017, p46 - 62 Journal Article, 2017 URL DOI

Prichard David O, Byrne Anne Marie, Murphy James O, Reynolds John V, O'Sullivan Jacintha, Feighery Ronan, Doyle Brendan, Eldin Osama Sharaf, Finn Stephen P, Maguire Aoife, Duff Deirdre, Kelleher Dermot P, Long Aideen, Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-αv trafficking , Journal of cellular and molecular medicine , 21 , (12 ), 2017, p3612 - 3625 Journal Article, 2017 TARA - Full Text DOI URL

Butler C.T, Reynolds A.L, Tosetto M, Dillon E.T, Guiry P.J, Cagney G, O'Sullivan J, Kennedy B.N, A quininib analogue and cysteinyl leukotriene receptor antagonist inhibits vascular endothelial growth factor (VEGF)-independent angiogenesis and exerts an additive antiangiogenic response with bevacizumab, Journal of Biological Chemistry, 292, (9), 2017, p3552 - 3567 Journal Article, 2017 DOI URL

Linda O'Neill, Emer Guinan, Suzanne L Doyle, Jessie A. Elliott, Jacintha O'Sullivan, John V. Reynolds, Juliette Hussey, Rehabilitation Strategies following esophageal cancer (the ReStOre trial): a feasibility study, Diseases of the Esophagus, 30, (5), 2017, p1 - 8 Journal Article, 2017 DOI

Phelan JJ, Feighery R, Eldin OS, Meachair SÓ, Cannon A, Byrne R, MacCarthy F, O'Toole D, Reynolds JV, O'Sullivan J, Examining the connectivity between different cellular processes in the Barrett tissue microenvironment., Cancer letters, 371, (2), 2016, p334-46 Journal Article, 2016 DOI

Kavanagh ME, Conroy MJ, Clarke NE, Gilmartin NT, O'Sullivan KE, Feighery R, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J, Lysaght J, Impact of the inflammatory microenvironment on T-cell phenotype in the progression from reflux oesophagitis to Barrett oesophagus and oesophageal adenocarcinoma., Cancer letters, 370, (1), 2016, p117-24 Journal Article, 2016 DOI

Clare T. Butler, Breandán N. Kennedy, William M. Gallagher, Jacintha O"Sullivan, Abstract 3058: Phenotype-based discovery and development of novel therapies for the treatment of colorectal cancer, Cancer Research, 76, (14_Supplement), 2016, p3058 - 3058, p3058-3058 Journal Article, 2016 DOI

Lorraine Burke, Clare T. Butler, Adrian Murphy, Bruce Moran, William M. Gallagher, Jacintha O"Sullivan, Breandán N. Kennedy, Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer, Frontiers in Cell and Developmental Biology, 4, 2016 Journal Article, 2016 DOI

Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397 Journal Article, 2016 DOI

Dowling C, Phelan J, Cathcart M, Mehigan B, McCormick P, Dalton T, Coffey C, Newton A, O'Sullivan J and Kiely P., Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival, Oncotarget, 7, 2016, p20919-20933 Journal Article, 2016 DOI TARA - Full Text

Moriarity A, O'Sullivan J, Kennedy J, Mehigan B, McCormick P, Current targeted therapies in the treatment of advanced colorectal cancer: A review, Therapeutic Advances in Medical Oncology, 8, (4), 2016, p276 - 293 Journal Article, 2016 DOI URL

Catríona M. Dowling, James J. Phelan, Julia A. Callender, Mary Clare Cathcart, Brian Mehigan, Paul McCormick, Tara Dalton, John Calvin Coffey, Alexandra C. Newton, Jacintha O"Sullivan, Patrick A. Kiely, Abstract 1888: Protein kinase C beta II suppresses colorectal cancer by regulating IGF1 mediated cell survival, Cancer Research, 76, (14_Supplement), 2016, p1888 - 1888, p1888-1888 Journal Article, 2016 DOI

O'Farrell N.J, Feighery R, Picardo S.L, Lynam-Lennon N, Biniecka M, McGarrigle S.A, Phelan J.J, MacCarthy F, O'Toole D, Fox E.J, Ravi N, Reynolds J.V, O'Sullivan J, Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence, BMC Cancer, 16, (1), 2016, p497- Journal Article, 2016 DOI TARA - Full Text URL

Murphy A.G, Casey R, Maguire A, Tosetto M, Butler C.T, Conroy E, Reynolds A.L, Sheahan K, O'Donoghue D, Gallagher W.M, Fennelly D, Kennedy B.N, O'Sullivan J, Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer, Scientific Reports, 6, 2016 Journal Article, 2016 DOI TARA - Full Text URL

Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200 Journal Article, 2016 DOI

Grainne M. O"Kane, Sarah A. McGarrigle, Nadia Rehill, Michael Farrell, Jacintha O"Sullivan, Cian Muldoon, Padraic Mac Mathúna, Desmond N. Carney, David Gallagher, Levels of oxidative stress and telomeres in Lynch syndrome-associated malignancies., Journal of Clinical Oncology, 34, (4_suppl), 2016, p582 - 582, p582-582 Journal Article, 2016 DOI

Picardo SL, O'Brien MP, Feighery R, O'Toole D, Ravi N, O'Farrell NJ, O'Sullivan JN, Reynolds JV, A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia., Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E, 28, (2), 2015, p121-126 Journal Article, 2015 TARA - Full Text DOI

Catríona M. Dowling, James J. Phelan, Mary Clare Cathcart, Brian Mehigan, Paul McCormick, Tara Dalton, John Calvin Coffey, Jacintha O"Sullivan, Patrick A. Kiely, Abstract 2136: Correlating the expression of protein kinase C isozymes with the transformed phenotype in colorectal cancer, Cancer Research, 75, (15_Supplement), 2015, p2136 - 2136, p2136-2136 Journal Article, 2015 DOI

James J. Phelan, Ciara O"Hanlon, John V. Reynolds, Jacintha O"Sullivan, The Role of Energy Metabolism in Driving Disease Progression in Inflammatory, Hypoxic and Angiogenic Microenvironments, Gastro - Open Journal, 1, (2), 2015, p44 - 58, p44-58 Journal Article, 2015 DOI

Clare T. Butler, Adrian Murphy, William M. Gallagher, Jacintha O"Sullivan, Breandán N. Kennedy, Abstract 1383: Phenotype-based development of novel therapies for the treatment of colorectal cancer, Cancer Research, 75, (15_Supplement), 2015, p1383 - 1383, p1383-1383 Journal Article, 2015 DOI

Karolina Weiner"Gorzel, Eugene Dempsey, Ma"gorzata Milewska, Aloysius McGoldrick, Valerie Toh, Aoibheann Walsh, Sinéad Lindsay, Luke Gubbins, Aoife Cannon, Daniel Sharpe, Jacintha O"Sullivan, Madeline Murphy, Stephen F. Madden, Malcolm R. Kell, Amanda McCann, Fiona Furlong, Resistance to chemotherapy in ovarian cancer is miRrored by the microRNA miR-433-dependent dysregulation of the cell cycle., 2015 Journal Article, 2015

El-Mashed S., O'Donovan T., Kay E., Abdallah A., Cathcart M., O'Sullivan J., O'Grady A., Reynolds J., O'Reilly S., O'Sullivan G., McKenna S., LC3B globular structures correlate with survival in esophageal adenocarcinoma, BMC Cancer, 15, (1), 2015, p582- Journal Article, 2015 TARA - Full Text DOI

Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M, McCann A, Furlong F, Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells., Cancer medicine, 4, (5), 2015, p745-58 Journal Article, 2015

Phelan JJ, O'Hanlon C, Reynolds JV and O'Sullivan J, The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments, Gastro., 1, (2), 2015, p44 - 58 Journal Article, 2015 TARA - Full Text

Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J, Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus., Gastroenterology, 148, (2), 2015, p367-78 Journal Article, 2015 DOI TARA - Full Text

O'Sullivan KE, Reynolds JV, O'Hanlon C, O'Sullivan JN, Lysaght J, Could signal transducer and activator of transcription 3 be a therapeutic target in obesity-related gastrointestinal malignancy?, Journal of gastrointestinal cancer, 45, (1), 2014, p1-11 Journal Article, 2014 DOI

O'Sullivan KE, Phelan JJ, O'Hanlon C, Lysaght J, O'Sullivan JN, Reynolds JV., The role of inflammation in cancer of the esophagus., Expert Reviews Gastroenterology Hepatology, 8, (7), 2014, p749 - 760 Journal Article, 2014 DOI TARA - Full Text

Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J, Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer., BMC cancer, 14, 2014, p887 Journal Article, 2014 TARA - Full Text DOI

Sheridan, J., Walsh, P., Kevans, D., (...), Mulcahy, H., Doherty, G. , Determinants of short- and long-term survival from colorectal cancer in very elderly patients, Journal of Geriatric Oncology , 5, (4), 2014, p376-83 Journal Article, 2014 TARA - Full Text DOI

Sarah A. McGarrigle, Emer Guinan, Juliette Hussey, Jacintha O"Sullivan, Michael J. Kennedy, David Gallagher, Elizabeth Connolly, Prospective evaluation of the potential to reduce breast cancer risk, through lifestyle modifications in BRCA-mutation carriers., Journal of Clinical Oncology, 32, (15_suppl), 2014, pe12506 - e12506, pe12506-e12506 Journal Article, 2014 DOI

Kavanagh, M.E., O'Sullivan, K.E., O'Hanlon, C., (...), Lysaght, J., Reynolds, J.V., The esophagitis to adenocarcinoma sequence; the role of inflammation, Cancer Letters, 345, (2), 2014, p182-189 Journal Article, 2014 DOI

Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J, Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC cancer, 14, 2014, p907 Journal Article, 2014 TARA - Full Text DOI

Phelan JJ, MacCarthy F, Feighery R, O'Farrell NJ, Lynam-Lennon N, Doyle B, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J, Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus., Cancer letters, 354, (1), 2014, p122-31 Journal Article, 2014 DOI TARA - Full Text

Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J, Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma., PloS one, 9, (6), 2014, pe100738 Journal Article, 2014 DOI TARA - Full Text

O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ, Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive., British journal of cancer, 111, (5), 2014, p927-32 Journal Article, 2014 DOI

Suzanne Slattery, Jillian P. Casey, Niamh Lynam"Lennon, Paul Gettigan, Jacintha O"Sullivan, Michael Mc Dermott, Karina Forde, Ina Knerr, Eileen P. Treacy, Ardeshir A. Monavari, Joanne Hughes, B. Bourke, Sean Ennis, Sally Ann Lynch, Melanie Cotter, Ellen Crushell, G86(P) Clinical Phenotype associated with recessive mutations in LARS gene, Archives of Disease in Childhood, 99, (Suppl 1), 2014, pA36 - A37, pA36-A37 Journal Article, 2014 DOI

Guinan, EM, Hussey, J, McGarrigle, SA, Healy, LA, O'Sullivan, JN, Bennett, K, Connolly, EM, A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers, BMC CANCER, 13, 2013, p138- Journal Article, 2013 TARA - Full Text DOI

Mary"Clare Cathcart, Jacintha O"Sullivan, Breandán N. Kennedy, John V. Reynolds, Graham P. Pidgeon, Abstract 5087: Thromboxane synthase and thromboxane receptor targeting have anti-angiogenic efficacy in-vivo and reduce angiogenic secretions from human colorectal tumor explants ex-vivo., Cancer Research, 73, (8_Supplement), 2013, p5087 - 5087, p5087-5087 Journal Article, 2013 DOI

Breandán N. Kennedy, Yolanda Álvarez, Miriam Tosetto, Temitope Sasore, Claire Kilty, Alan W. Stitt, Jacintha O"Sullivan, Alison Reynolds, Chemical Screens in Zebrafish Identify Novel Inhibitors of Retinal Neovascularisation in Mouse, Investigative Ophthalmology & Visual Science, 54, (15), 2013, p4617 - 4617, p4617-4617 Journal Article, 2013

Sheridan, J. Tosetto, M. Gorman, J. O'Donoghue, D. Sheahan, K. Hyland, J. Mulcahy, H. Gibbons, D. O'Sullivan, J., Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases, Journal of Gastrointestinal Cancer, 44, (1), 2013, p41 - 45 Journal Article, 2013 DOI URL

Niamh Lynam"Lennon, Stephen G. Maher, John V. Reynolds, Jacintha O"Sullivan, Abstract 1592: Mitochondrial dysfunction and radioresistance in esophageal cancer., Cancer Research, 73, (8_Supplement), 2013, p1592 - 1592, p1592-1592 Journal Article, 2013 DOI

Hu, J, Locasale, JW, Bielas, JH, O'Sullivan, J, Sheahan, K, Cantley, LC, Vander Heiden, MG, Vitkup, D, Heterogeneity of tumor-induced gene expression changes in the human metabolic network, NATURE BIOTECHNOLOGY, 31, (6), 2013, p522-U11 Journal Article, 2013 DOI

Doyle, B., Hagan, S., Al-Mulla, F., (...), O'Sullivan, J., Kolch, W. , Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients , Histopathology , 62, (3), 2013, p505-510 Journal Article, 2013 URL

Brendan Doyle, Suzanne Hagan, Fahd Al"Mulla, Lucy Scott, Sharon Harden, James Paul, Hugh Mulcahy, Graeme I. Murray, Kieran Sheahan, Jacintha O"Sullivan, Walter Kölch, Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients, Histopathology, 62, (3), 2012, p505 - 510, p505-510 Journal Article, 2012 DOI

Kevans D, Gorman S, Tosetto M, Sheahan K, O'Donoghue D, Mulcahy H and O'Sullivan J. , Clusterin and chemotherapy sensitivity under normoxic graded hypoxic conditions in colorectal cancer , Journal of Gastrointestinal Cancer , 43, (2), 2012, p305-313 Journal Article, 2012 DOI

Petra Martin, Sinéad Noonan, Bláthnaid Nolan, Caitríona Scaife, Giuliano Elia, Diarmuid P. O"Donoghue, D. Fennelly, Jacintha O"Sullivan, Characterization of serum proteome in patients with metastatic colorectal cancer responsive and nonresponsive to bevacizumab using 2 d-DIGE., Journal of Clinical Oncology, 30, (4_suppl), 2012, p484 - 484, p484-484 Journal Article, 2012 DOI

Mary-Clare Cathcart, Kenneth J. O'Byrne, John V. Reynolds, Jacintha O' Sullivan, Graham P. Pidgeon, COX-Derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1825, (1), 2012, p49-63 Journal Article, 2012 TARA - Full Text

Michielsen AJ, Ryan EJ, O'Sullivan JN, Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment., Oncoimmunology, 1, (8), 2012, p1445-1447 Journal Article, 2012 DOI TARA - Full Text URL

Canney, AL, Kevans, D, Wang, LM, Hyland, JMP, Mulcahy, HE, O'Donoghue, DP, O'Sullivan, J, Geraghty, R, Sheahan, K, Stage II colonic adenocarcinoma: a detailed study of pT4N0 with emphasis on peritoneal involvement and the role of tumour budding, HISTOPATHOLOGY, 61, (3), 2012, p488-496 Journal Article, 2012 DOI

Leonard C Harty, Monika Biniecka, Jacintha O'Sullivan, Edward Fox, Kevin Mulhall, Douglas J Veale, Ursula Fearon, Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis, Annals of the Rheumatic Diseases: The EULAR Journal, 71, (4), 2012, p582-588 Journal Article, 2012 DOI TARA - Full Text

Adrian Murphy, Rory Casey, D. Fennelly, Alison Reynolds, Miriam Tosetto, John Hyland, Kieran Sheahan, Diarmuid O"Donoghue, Hugh Mulcahy, Breandán N. Kennedy, Jacintha O"Sullivan, The effect of novel small molecule drugs in human explants across the disease sequence in colorectal cancer., Journal of Clinical Oncology, 30, (15_suppl), 2012, pe13570 - e13570, pe13570-e13570 Journal Article, 2012 DOI

Sinéad Noonan, Petra Martin, Aoife Maguire, Monika Biniecka, Miriam Tosetto, John Hyland, Kieran Sheahan, Diarmuid P. O"Donoghue, Hugh Mulcahy, D. Fennelly, Jacintha O"Sullivan, Correlation of markers of oxidative damage and circulating IL6 levels with survival following treatment with bevacizumab in metastatic colorectal cancer patients., Journal of Clinical Oncology, 30, (15_suppl), 2012, pe21024 - e21024, pe21024-e21024 Journal Article, 2012 DOI

Michielsen, AJ, Noonan, S, Martin, P, Tosetto, M, Marry, J, Biniecka, M, Maguire, AA, Hyland, JM, Sheahan, KD, O'Donoghue, DP, Mulcahy, HE, Fennelly, D, Ryan, EJ, O'Sullivan, JN, Inhibition of Dendritic Cell Maturation by the Tumor Microenvironment Correlates with the Survival of Colorectal Cancer Patients following Bevacizumab Treatment, MOLECULAR CANCER THERAPEUTICS, 11, (8), 2012, p1829-1837 Journal Article, 2012 DOI

Picardo SL, Maher SG, O'Sullivan JN, Reynolds JV, Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer., Digestive surgery, 29, (3), 2012, p251-60 Journal Article, 2012 DOI

Ericson, NG, Kulawiec, M, Vermulst, M, Sheahan, K, O'Sullivan, J, Salk, JJ, Bielas, JH, Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer, PLOS GENETICS, 8, (6), 2012, pe1002689- Journal Article, 2012 DOI TARA - Full Text

Kirsha Naicker, Donal J. Brennan, Rut Klinger, Fredrik Pontén, Karin Jirström, Jacintha O"Sullivan, William M. Gallagher, Darran P. O"Connor, Abstract LB-444: SATB2 is a novel prognostic factor in colorectal cancer, Cancer Research, 72, (8_Supplement), 2012, pLB - 444, pLB-444 Journal Article, 2012 DOI

Kevans, D, Wang, LM, Sheahan, K, Hyland, J, O'Donoghue, D, Mulcahy, H, O'Sullivan, J, Epithelial-Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status, INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 19, (6), 2011, p751-760 Journal Article, 2011 DOI

Kennedy, A., Teck Ng, C., Cheng Chang, T., (...), Fearon, U., Veale, D.J., Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia, Arthritis and Rheumatism, 63, (4), 2011, p923-932 Journal Article, 2011 DOI

Kennedy RD, Bylesjo M, Kerr P, Davison T, Black JM, Kay EW, Holt RJ, Proutski V, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, McDyer F, Mulligan K, Mussen J, O'Brien E, Oliver G, Walker SM, Mulligan JM, Wilson C, Winter A, O'Donoghue D, Mulcahy H, O'Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe OF, Winqvist O, Manne U, Shanmugam C, Ramaswamy S, Leon EJ, Smith WI, McDermott U, Wilson RH, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG, Harkin DP, Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29, (35), 2011, p4620-6 Journal Article, 2011 DOI

Sapetto-Rebow, B., McLoughlin, S.C., O'Shea, L.C., (...), Hensey, C., Kennedy, B.N. , Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a -/- mutants, BMC Developmental Biology , 11, 2011, p71- Journal Article, 2011 TARA - Full Text DOI

Biniecka M, Fox E, Gao W, Ng CT, Veale DJ, Fearon U, O'Sullivan J, Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis., Arthritis and rheumatism, 63, (8), 2011, p2172-82 Journal Article, 2011

Biniecka M, Kennedy A, Ng CT, Chang TC, Balogh E, Fox E, Veale DJ, Fearon U, O'Sullivan JN., Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis, Arthritis Research & Therapy , 13, (4), 2011, pR121 Journal Article, 2011 DOI TARA - Full Text URL

Biniecka, M., Fox, E., Gao, W., (...), Fearon, U., O'Sullivan, J., Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis, Arthritis and Rheumatism, 63, (8), 2011, p2172-2182 Journal Article, 2011

Michielsen, AJ, Hogan, AE, Marry, J, Tosetto, M, Cox, F, Hyland, JM, Sheahan, KD, O'Donoghue, DP, Mulcahy, HE, Ryan, EJ, O'Sullivan, JN, Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer, PLOS ONE, 6, (11), 2011, pe27944- Journal Article, 2011 TARA - Full Text DOI

Doherty G, Walsh P, Sheridan J, Kevans D, Keegan D, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J and Mulchay H. , Clinical and Pathological Factors associated with colorectal cancer at the Upper extreme of life, Journal of the American Geriatrics Society, 58, (4), 2010 Journal Article, 2010

Byrne A, Foran E, Sharma R, Davis A, Mahon C, O'Sullivan J, O'Donoghue D, Kelleher D, Long A. , Opposing effects of Deoxycholic and Ursodeoxycholic acid on Golgi Structure: implications for colon cancer progression., Carcinogenesis, 31, (4), 2010, p737-44 Journal Article, 2010

Young O, Crotty T, O'Connell R, O'Sullivan J and Curran A. , Levels of oxidative damage and lipid peroxidation in thyroid neoplasia. , Head Neck, 32, (6), 2010, p750-756 Journal Article, 2010

Biniecka M, Kennedy A, T Ng C, Fearon U, Douglas J Veale, O'Sullivan J. , Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint, Annals of the Rheumatic Diseases, 69, (6), 2010 Journal Article, 2010

Adriana J. Michielsen, Jacintha O"Sullivan, Elizabeth J. Ryan, Recent Advances in the Development of Novel Therapeutics Targeting Dendritic Cells, Recent Patents on Endocrine Metabolic & Immune Drug Discovery, 4, (2), 2010, p146 - 152, p146-152 Journal Article, 2010 DOI

Byrne AM, Foran E, Sharma R, Davies A, Mahon C, O'Sullivan J, O'Donoghue D, Kelleher D, Long A, Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells., Carcinogenesis, 31, (4), 2010, p737-744 Journal Article, 2010 TARA - Full Text DOI

Gorman S, Fox E, O'Donoghue D, Sheahan K, Hyland J, Mulcahy H, Loeb L and O'Sullivan J., Mitochondrial mutagenesis induced by tumour specific radiation bystander effects , Journal of Molecular Medicine, 88, (7), 2010, p701 - 8 Journal Article, 2010

Bronner M, Skacel M, Crispin D, Hoff P, Emond M, Lai L, Tubbs R, O'Sullivan J, Rabinovitch P and Brentnall T., Array-based comparative genomic hybridization in ulcerative colitis neoplasia: single non dysplastic biopsies distinguish progressors from non progressors, Modern Pathology, 23, (12), 2010 Journal Article, 2010

Howe O, O' Sullivan J, Nolan B, Vaughan J, Clarke C, Gorman S, McClean B, Lyng F, Do radiation-induced bystander effects correlate to the intrinsic radiosensitivity of individuals and have clinical significance? , Radiation Research, 171, 2009, p521-529. Journal Article, 2009

Sullivan S, Tosetto M, Kevans D, Coss A, Wang L, O'Donoghue D, Hyland J, Fennelly D, Sheahan K, Mulcahy H & O'Sullivan J. , Localization of a nuclear Cathepsin L and its association with disease progression and poor outcome in colorectal cancer. , Int J Cancer, 1;125, (1), 2009, p54-61 Journal Article, 2009

Kevans D, Foley J, Tenniswood M, Sheahan K, Hyland J, O'Donoghue D, Mulchay H and O'Sullivan J. , High clusterin expression correlates with a poor outcome in Stage II T3NO colorectal cancer. , Cancer Epidemiology Biomarkers and Prevention, 18, (2), 2009, p393-399 Journal Article, 2009

Watson J, Watson C, McCrohan A, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O'Sullivan J, Murrell A, Watson W and McCann A. , Generation of an epigenetic signature by chronic hypoxia in prostate cells., Hum Mol Genet., 1;18, (19), 2009, p3594-604. Journal Article, 2009

Coss A, Tosetto M, Fox E, Sapetto-Rebow B, Gorman S, Kennedy B, Lloyd, Hyland J, O'Donoghue D, Sheahan K, Leahy D, Mulcahy H, O'Sullivan J. , Increased Topoisomerase IIα Expression in Colorectal Cancer is Associated with Pathologically Aggressive Disease and Leads to Chemotherapy Resistance via Inhibition of Apoptosis. , Cancer Lett., 276, (2), 2009, p228-238 Journal Article, 2009

Coss, A, Tosetto, M, Fox, EJ, Sapetto-Rebow, B, Gorman, S, Kennedy, BN, Lloyd, AT, Hyland, JM, O'Donoghue, DP, Sheahan, K, Leahy, DT, Mulcahy, HE, O'Sullivan, JN, Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis., Cancer letters, 276, (2), 2009 Journal Article, 2009 DOI

Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Furlong F, Harrison M, O'Sullivan J, McCann A. , Cellular senescence induced by abberant MAD2 levels impacts on paclitaxel responsiveness in vitro. , Br J Cancer. , 1:101, (11), 2009, p1900-8 Journal Article, 2009

Wang L, Kevans D, Mulcahy H, O'Sullivan J, Hyland J, O'Donoghue D and Sheahan K. , Tumour budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. , The American Journal of Surgical Pathology, 33, (1), 2009, p134-141 Journal Article, 2009

Gorman S, Tosetto M, Lyng F, Howe O, Sheahan K, O'Donoghue D, Hyland J, Mulcahy H and O'Sullivan J. , Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction. , Mutat Res. , 2, (669), 2009, p1-2 Journal Article, 2009

Sheridan J, Wang L, Tosetto M, Dave Kevans, Hyland J, Sheahan K, O'Donoghue D, Mulcahy H & O'Sullivan J. , High levels of 8-Hydroxyguanine, a marker of oxidative DNA Damage predicts overall survival in sporadic colorectal cancer, Br J Cancer., 100, (2), 2009, p381-388. Journal Article, 2009

O'Sullivan J, Sheridan J, Mulcahy H, Tenniswood M, Morrissey C, The effect of green tea on oxidative damage and tumour formation in Lobund-Wistar rats., European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 17, (6), 2008, p489-501 Journal Article, 2008

Bronner MP, O'Sullivan JN, Rabinovitch PS, Crispin DA, Chen L, Emond MJ, Rubin CE, Brentnall TA, Genomic biomarkers to improve ulcerative colitis neoplasia surveillance., The American journal of pathology, 173, (6), 2008, p1853-60 Journal Article, 2008

Lynch, L, O'Donoghue, D, Dean, J, O'Sullivan, J, O'Farrelly, C, Golden-Mason, L, Detection and characterization of hemopoietic stem cells in the adult human small intestine., Journal of immunology (Baltimore, Md. : 1950), 176, (9), 2006, p5199-204 Journal Article, 2006 URL

O'Sullivan J, Risques RA, Mandelson MT, Chen L, Brentnall TA, Bronner MP, Macmillan MP, Feng Z, Siebert JR, Potter JD, Rabinovitch PS, Telomere length in the colon declines with age: a relation to colorectal cancer?, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15, (3), 2006, p573-7 Journal Article, 2006

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Rabinovitch PS, Quantitative fluorescence in situ hybridization (QFISH) of telomere lengths in tissue and cells., Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.], Chapter 12, 2005, pUnit 12.6 Journal Article, 2005

O'Sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Moskovitz AH, Gryaznov S, Harley CB, Rabinovitch PS, Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms., Cytometry. Part A : the journal of the International Society for Analytical Cytology, 58, (2), 2004, p120-31 Journal Article, 2004

Zierau O, O'Sullivan J, Morrissey C, McDonald D, Wünsche W, Schneider MR, Tenniswood MP, Vollmer G, Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus., Endocrine-related cancer, 11, (4), 2004, p823-30 Journal Article, 2004

O'Sullivan J, Whyte L, Drake J, Tenniswood M, Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis., Cell death and differentiation, 10, (8), 2003, p914-27 Journal Article, 2003

Morrissey C, Buser A, Scolaro J, O'Sullivan J, Moquin A, Tenniswood M, Changes in hormone sensitivity in the ventral prostate of aging Sprague-Dawley rats., Journal of andrology, 23, (3), 2002, p341-51 Journal Article, 2002

O'Sullivan JN, Bronner MP, Brentnall TA, Finley JC, Shen WT, Emerson S, Emond MJ, Gollahon KA, Moskovitz AH, Crispin DA, Potter JD, Rabinovitch PS, Chromosomal instability in ulcerative colitis is related to telomere shortening., Nature genetics, 32, (2), 2002, p280-4 Journal Article, 2002

Tenniswood M, Wang Z, Lakins J, Morrissey C, O'Sullivan J, Tang H, Clusterin in the male reproductive tract., Journal of andrology, 19, (5), 1998, p508-16 Journal Article, 1998

Lakins J, Bennett SA, Chen JH, Arnold JM, Morrissey C, Wong P, O'Sullivan J, Tenniswood M, Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate., The Journal of biological chemistry, 273, (43), 1998, p27887-95 Journal Article, 1998

Non-Peer-Reviewed Publications

Alina Qaisar, Jacintha O'Sullivan, Niamh M. O'Boyle, P22: Synthesis and Physicochemical Properties of Amino Acid Prodrugs of the Radiosensitser Pyrazinib, 30th Annual GP2A Medicinal Chemistry Conference, Dublin, 24-26 August 2022, 2022 Poster, 2022