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Trinity College Dublin, The University of Dublin

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Dr. Anne Mc Gettrick-Dillon
Senior Research Fellow, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ., Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. , Nature, 2023, p32 Journal Article, 2023 TARA - Full Text DOI

McGettrick AF, O'Neill LA., Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite., Current opinion in immunology, 80, 2023, p102268 Journal Article, 2023 DOI

McGettrick, A.F. and O†Neill, L.A.J., The itaconate family of immunomodulators grows, Nature Metabolism, 4, (5), 2022, p499-500 Journal Article, 2022 DOI

Runtsch, M.C. and Angiari, S. and Hooftman, A. and Wadhwa, R. and Zhang, Y. and Zheng, Y. and Spina, J.S. and Ruzek, M.C. and Argiriadi, M.A. and McGettrick, A.F. and Mendez, R.S. and Zotta, A. and Peace, C.G. and Walsh, A. and Chirillo, R. and Hams, E. and Fallon, P.G. and Jayamaran, R. and Dua, K. and Brown, A.C. and Kim, R.Y. and Horvat, J.C. and Hansbro, P.M. and Wang, C. and O'Neill, L.A.J., Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages, Cell Metabolism, 34, (3), 2022, p487-501.e8 Journal Article, 2022 DOI

Diskin, C. and Corcoran, S.E. and Tyrrell, V.J. and McGettrick, A.F. and Zaslona, Z. and O'Donnell, V.B. and Nolan, D.P. and O'Neill, L.A.J., The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2, Journal of immunology (Baltimore, Md. : 1950), 207, (10), 2021, p2551-2560 Journal Article, 2021 DOI

McGettrick, A.F. and O'Neill, L.A.J., The Role of HIF in Immunity and Inflammation, Cell Metabolism, 32, (4), 2020, p524-536 Journal Article, 2020 DOI

Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E Corcoran, Marah C Runisch, Chris Ling, Melanie C Ruzek, Peter F Slivka, Anne F McGettrick, Kathy Banahan, Mark M Hughes, Alan D Irvine, Roman Fischer, Luke A J O'Neill, The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation, Cell Metabolism, 2020 Journal Article, 2020 DOI TARA - Full Text

Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 Journal Article, 2019 TARA - Full Text DOI

Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117 Journal Article, 2018 DOI

Hughes M.M, Mcgettrick A.F, O'Neill L.A.J, Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages, Microbiology Spectrum, 5, (1), 2017, p0044- Journal Article, 2017 DOI URL

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 Journal Article, 2016 DOI

Connolly DJ, O'Neill LA, McGettrick AF., The GOLD domain-containing protein TMED1 is involved in interleukin-33 signaling, Journal of Biological Chemistry, 288, (8), 2013, p5616 - 5623 Journal Article, 2013 URL

Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ Journal Article, 2013 DOI TARA - Full Text

McGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, (32), 2013, 22893-22898 Journal Article, 2013 TARA - Full Text DOI

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, , The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation, Nature communications, 3, 2012, p7 - 10 Journal Article, 2012 URL

McGettrick AF, O'Neill LA, Localisation and trafficking of Toll-like receptors: an important mode of regulation. , Current Opinion in Immunology, 22, (1), 2010, p20-27 Journal Article, 2010 DOI

Palsson-McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock , Espevik T and O'Neill LAJ, TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling, Nature Immunology, 10, 2009, p579 - 586 Journal Article, 2009 DOI

McGettrick AF, O'Neill LA., Toll-like receptors: key activatory of leucocytes and regulator of haematopoiesis, Br J Haematol., 139, (2), 2007, p185-93 Journal Article, 2007 URL DOI

McGettrick, A, Brint EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay NJ, Fitzgerald, KA and O'Neill LA, Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling, Proceedings of the National Academy of Sciences , 103, (24), 2006, p9196 - 9201 Journal Article, 2006 DOI TARA - Full Text

Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proceedings of the National Academy of Sciences , 103, (16), 2006, p6299 - 6304 Journal Article, 2006 DOI TARA - Full Text

A. F. McGettrick and L. A. O'Neill, The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction, Mol Immunol, 41, (6-7), 2004, p577-82 Journal Article, 2004 URL DOI

Hardy, M, McGettrick, A and O'Neill, LAJ , Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene., Biochemical Journal, 380, (1), 2004, p83 - 93 Journal Article, 2004 TARA - Full Text DOI

Hardy MP, McGettrick AF, O'Neill LAJ, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, Biochemical Journal, 380, (1), 2004, p83 - 93 Journal Article, 2004 URL