Professor Tríona Lally
Professor in BioEngineering, Mechanical, Manuf & Biomedical Eng
Biography
Dr. Caitríona Lally received her BEng (Mechanical Engineering) and MEng (Biomedical Engineering) degrees from University of Limerick and later obtained a PhD from Trinity College Dublin in the area of arterial biomechanics and cardiovascular stenting. In March 2004 she took up a lecturing position in the School of Mechanical & Manufacturing Engineering at Dublin City University, and was appointed senior lecturer in 2014. In 2015, she joined the Department of Mechanical & Manufacturing Engineering in Trinity College Dublin as a Professor in Bioengineering where she continues to carry out research focused on arterial tissue mechanics, vascular imaging, vascular mechanobiology and tissue engineering. She has secured considerable research funding from SFI, Enterprise Ireland and the IRC and was awarded an ERC starting grant in 2014.
Publications and Further Research Outputs
Peer-Reviewed Publications
Tornifoglio B., Johnston R.D., Stone A.J., Kerskens C., Lally C., Microstructural and mechanical insight into atherosclerotic plaques: an ex vivo DTI study to better assess plaque vulnerability, Biomechanics and Modeling in Mechanobiology, 2023
Johnston, Robert D., Ghasemi, Milad, Lally, Caitríona, Inverse material parameter estimation of patient"specific finite element models at the carotid bifurcation: The impact of excluding the zero"pressure configuration and residual stress, International Journal for Numerical Methods in Biomedical Engineering, 39, (1), 2023
Tornifoglio B., Stone A.J., Kerskens C., Lally C., Ex Vivo Study Using Diffusion Tensor Imaging to Identify Biomarkers of Atherosclerotic Disease in Human Cadaveric Carotid Arteries, Arteriosclerosis, Thrombosis, and Vascular Biology, 42, (11), 2022, p1398 - 1412, p1398-1412
Ghasemi M., Nolan D.R., Lally C., Assessment of mechanical indicators of carotid plaque vulnerability: Geometrical curvature metric, plaque stresses and damage in tissue fibres, Journal of the Mechanical Behavior of Biomedical Materials, 103, 2020
Brooke Tornifoglio, Alan J. Stone, Robert D. Johnston, Salmon S. Shahid, Christian Kerskens, Caitriona Lally, Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography, Scientific Reports, 2020
Mathieu P.S., Fitzpatrick E., Di Luca M., Cahill P.A., Lally C., Resident multipotent vascular stem cells exhibit amplitude dependent strain avoidance similar to that of vascular smooth muscle cells, Biochemical and Biophysical Research Communications, 521, (3), 2020, p762 - 768, p762-768
Alix Whelan, Elizabeth Williams, David Nolan, Bruce Murphy, Paul Gunning, David O'Reilly, Caitríona Lally, Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue , Annals of Biomedical Engineering, 2020
Schipani, R. and Nolan, D.R. and Lally, C. and Kelly, D.J., Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering, Connective Tissue Research, 2019
Alix Whelan, Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium, Journal of the Mechanical Behavior of Biomedical Materials, 90, 2019, p54 - 60
Clarkin O.M., Wu B., Cahill P.A., Brougham D.F., Banerjee D., Brady S.A., Fox E.K., Lally C., Novel injectable gallium-based self-setting glass-alginate hydrogel composite for cardiovascular tissue engineering, Carbohydrate Polymers, 217, 2019, p152 - 159, p152-159
Robert Gaul, David Nolan, Tomasso Ristori, Carlijn Bouten, Sandra Loerakker, Caitriona Lally, Strain Mediated Arterial Degradation is Critically Influenced by Matrix Content and Collagen Crimp, Proceedings of the 24th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Meath, Ireland, 2018
Robert Gaul, David Nolan, Tomasso Ristori, Carlijn Bouten, Sandra Loerakker, Caitriona Lally, Strain mediated Enzymatic Degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp, Acta Biomaterialia, 2018
Robert Gaul, David Nolan, Tomasso Ristori, Carlijn Bouten, Sandra Loerakker, Caitriona Lally, Degradation of arterial collagen with applied strain: critical influence of matrix content and collagen crimp, 8th World Congress of Biomechanics, Dublin, Ireland, 8-12 July, 2018
Milad Ghasemi, David Nolan, Caitríona Lally , An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development, Biomechanics and Modeling in Mechanobiology, 2018
Robert Gaul, David Nolan, Caitríona Lally, The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo , Journal of Biomechanics, 2018
Coupled Finite Element-Agent Based Models for the Simulation of Vascular Growth and Remodeling in, editor(s)Miguel Cerrolaza Sandra J. Shefelbine Diego Garzon-Alvarado , Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes, Elsevier, 2017, pp283 - 298, [David Nolan, Caitriona Lally]
Robert Gaul, Caitriona Lally, Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design, Summer Biomechanics, Bioengineering and Biotransport Conference 2017, Arizona, USA, June 2017, 2017
Robert Gaul, David Nolan, Caitriona Lally, Collagen fibre characterisation in arterial tissue under load using SALS, Journal of the Mechanical Behavior of Biomedical Materials, 75, 2017, p359 - 368
David Nolan; Caitríona Lally, An in-silico investigation into the influence of endothelial denudation on the progression on in-stent restenosis, European Society of Biomechanics, Seville, 2017
Shahid, Syed Salman, Christian, Kerskens, Caitriona, Lally, Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall, Bioengineering in Ireland, Belfast, 20-10-2017, 2017
Syed salman Shahid, Christian Kerskens, Robert Gaul, Caitriona Lally, Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging, European Molecular Imaging Meeting, Germany, 5-04-2017, 2017
Syed Salman Shahid, Robert Gaul, Christian Kerskens, Vittoria Flamini, Caitriona Lally, Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging - Comparison of intact vs. open cut tissue , Physics in Medicine and Biology, 62, (23), 2017, p8850 - 8868
David Nolan, Assessment of a Clinically Relevant Geometric Measure for Identifying Vulnerable Carotid Plaques, Bioengineering in Ireland, Belfast, 2017
David R. Nolan, Caitríona Lally, An Investigation of Damage Mechanisms in Mechanobiological Models of In-Stent Restenosis, Journal of Computational Science, 2017
David Nolan, Caitriona Lally, A Mechanobiological Framework for the Prediction of In-Stent Restenosis; Insights into the role of load induced damage in restenotic growth, The Virtual Physiological Human Conference, Amsterdam, 26/09/2016, edited by Alfons Hoekstra , 2016
Syed Salman Shahid, Christian Kerskens, Robert Gaul, Vittoria Flamini, Caitriona Lally, Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging, European Society for Magnetic Resonance in Medicine and Biology , Vienna, Austria, 29-09-2017, 2016
McCartney, W.T., Galvin, E., Cummins, C., Lally, C., Mac Donald, B.J., Use of a biodegradable magnesium implant for Osseous fixation in four cases, International Journal of Applied Research in Veterinary Medicine, 13, (3), 2015, p171-174
Flamini V, Creane A.P, Kerskens C.M, Lally C, Imaging and finite element analysis: A methodology for non-invasive characterization of aortic tissue, Medical Engineering and Physics, 37, (1), 2015, p48 - 54
Robert Gaul, Thomas Sinnott, Caitriona Lally, The automated characterisation of collagen fibre orientation in arteries using small angle light scattering, UK Society for Biomaterials, Belfast, Ireland, 2015
Zahedmanesh, H., Van Oosterwyck, H., Lally, C., A multi-scale mechanobiological model of in-stent restenosis: deciphering the role of matrix metalloproteinase and extracellular matrix changes, Computer Methods in Biomechanics and Biomedical Engineering, 17, (8), 2014, p813-828
Colombo, A., Guha, S., Mackle, J.N., Cahill, P.A., Lally, C., Cyclic strain amplitude dictates the growth response of vascular smooth muscle cells in vitro: Role in in-stent restenosis and inhibition with a sirolimus drug-eluting stent, Biomechanics and Modeling in Mechanobiology, 12, (4), 2013, p671-683
Galvin, E., Morshed, M.M., Cummins, C., Daniels, S., Lally, C., MacDonald, B., Surface modification of absorbable magnesium stents by reactive ion etching, Plasma Chemistry and Plasma Processing, 33, (6), 2013, p1137-1152
Flamini V, Kerskens C, Moerman K, Simms CK and Lally C, Fibre orientation of fresh and frozen porcine aorta determined non-invasively, Medical Engineering and Physics, 35, (6), 2013, 765-776
Eoghan Maher, Arthur Creane, Caitríona Lally, Daniel J. Kelly, An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue, Journal of the Mechanical Behavior of Biomedical Materials, 12, 2012, p9-19
Brackmann, C., Dahlberg, J.-O., Vrana, N.E., Lally, C., Gatenholm, P., Enejder, A., Non-linear microscopy of smooth muscle cells in artificial extracellular matrices made of cellulose, Journal of Biophotonics, 5, (5-6), 2012, p404-414
Maher E, Early M, Creane A, Lally C, Kelly DJ, Site specific inelasticity of arterial tissue., Journal of biomechanics, 45, (8), 2012, p1393-1399
Patient Specific Computational Modeling in Cardiovascular Mechanics in, Patient-Specific Computational Modeling, 2012, pp61-79 , [A Creane, DJ Kelly, C Lally. ]
Zahedmanesh, H., Lally, C., A multiscale mechanobiological modelling framework using agent-based models and finite element analysis: Application to vascular tissue engineering, Biomechanics and Modeling in Mechanobiology, 11, (3-4), 2012, p363-377
Redmond, E.M., Lally, C., Cahill, P.A., Hemodynamic control of vascular smooth muscle function, Muscle, 2, 2012, p1231-1242
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations., Biomechanics and Modeling in Mechanobiology, 11, (6), 2012, p869-882
Campbell, E.M., Cahill, P.A., Lally, C., Investigation of a small-diameter decellularised artery as a potential scaffold for vascular tissue engineering; biomechanical evaluation and preliminary cell seeding, Journal of the Mechanical Behavior of Biomedical Materials, 14, 2012, p130-142
Guha, S., Cullen, J.P., Morrow, D., Colombo, A., Lally, C., Walls, D., Redmond, E.M., Cahill, P.A., Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: Role in cell proliferation and survival, Basic Research in Cardiology, 106, (5), 2011, p773-785
Zahedmanesh, H., MacKle, J.N., Sellborn, A., Drotz, K., Bodin, A., Gatenholm, P., Lally, C., Bacterial cellulose as a potential vascular graft: Mechanical characterization and constitutive model development, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 97 B, (1), 2011, p105-113
Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J., Inelasticity of Human Carotid Atherosclerotic Plaque. , Annals of Biomedical Engineering, 39, (9), 2011, p2445-2455
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Nagel, T., Kelly, D.J., Prediction of fibre architecture and adaptation in diseased carotid bifurcations. , Biomechanics and Modeling in Mechanobiology , 10, (6), 2011, p831-843
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. , Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography., Computers in Biology and Medicine, 40, (4), 2010, p419-429
Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents., Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, (1921), 2010, p2919-35
Zahedmanesh, H., Kelly, D.J., Lally, C. , Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy, Journal of Biomechanics, 43, (11), 2010, p2126-2132
Flamini V, Kerskens C, Moerman K, Simms C and Lally C, Imaging arterial fibres using diffusion tensor imaging - feasibility study & preliminary results, EURASIP Journal on Advances in Signal Processing, 2010, 2010, pArticle ID 904091
Colombo, A., Zahedmanesh, H., Toner, D.M., Cahill, P.A., Lally, C., A method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments, Journal of the Mechanical Behavior of Biomedical Materials, 3, (6), 2010, p470-477
Vittoria Flamini, Christian Kerskens, Kevin Mattheus Moerman, Ciaran Simms and Caitríona Lally , Imaging Arterial Fibres Using Diffusion Tensor Imaging-Feasibility Study and Preliminary Results, EURASIP Journal on Advances in Signal Processing, 2010, (904091), 2010
Moerman, KM ; Kerskens, CM ; Lally, C ; Flamini, V ; Simms, CK , Evaluation of a Validation Method for MR Imaging-Based Motion Tracking Using Image Simulation, EURASIP Journal on Advances in Signal Processing, 2010, 2010, p942131
Boyle, C.J., Lally, C., Prendergast, P.J, Injury driven biological model of restenotic lesion development predicts the effects of stent geometry on restenosis, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, 11th ASME Summer Bioengineering Conference, SBC2009, Lake Tahoe, edited by 17-21 June , PART B, ASME, 2009, pp1055-1056
Zahedmanesh, H., Gatenholm, P., Lally, C., Bacterial cellulose: A potential vascular graft and tissue engineering scaffold, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p519-520
Michael Early; Catriona Lally; Patrick J. Prendergast; Daniel J. Kelly, Stresses in peripheral arteries following stent placement: a finite element analysis, Computer Methods in Biomechanics and Biomedical Engineering, 12, (1), 2009, p25 - 33
Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Patient specific finite element modelling of the carotid bifurcation, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p529-530
Flamini, V., Kerskens, C., Lally, C., An anisotropic structural model of the aortic wall based on tensile tests and non-invasive 3D fibre analysis using diffusion tensor imaging, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p411-412
Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C., Kelly, D.J., Mechanical characterization of fresh human carotid atherosclerotic plaque, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART B), 2009, p1307-1308
Zahedmanesh, H., Lally, C., Determination of the influence of stent strut thickness using the finite element method: Implications for vascular injury and in-stent restenosis, Medical and Biological Engineering and Computing, 47, (4), 2009, p385-393
Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. , Tensile and compressive properties of fresh human carotid atherosclerotic plaques. , Journal of Biomechanics, 42, (16), 2009, p2760-2767
Pericevic, I., Lally, C., Toner, D., Kelly, D.J. , The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents, Medical Engineering and Physics , 31, (4), 2009, p428-433
Lally, C., Sellborn, A., Bodin, A., Bäckdahl, H., Gatenholm, P., Risberg, B., Mechanical characterization of bacterial cellulose tubes for vascular tissue engineering, 8th World Biomaterials Congress 2008, 2, 2008
Colombo, A., Cahill, P.A., Lally, C., An analysis of the strain field in biaxial Flexcell membranes for different waveforms and frequencies, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 222, (8), 2008, p1235-1245
Lally, C., Dolan, F., Prendergast, P.J., Erratum to "Cardiovascular stent design and vessel stresses: A finite element analysis". [Journal of Biomechanics 38 (2005) 1574-1581] (DOI:10.1016/j.jbiomech.2004.07.022), Journal of Biomechanics, 39, (9), 2006
Lally, C, Dolan, F, Prendergast, PJ, Cardiovascular stent design and blood vessel stress: a finite element analysis, Journal of Biomechanics, 38, (8), 2005, p1574 - 1581
Lally, C, Reid, AJ, Prendergast, PJ, Elastic behaviour of porcine coronary arteries under uniaxial and equibiaxial tension, Annals of Biomedical Engineering, 32, 2004, p1355 - 1364
Prendergast, PJ, Lally, C, Daly, S, Lee, TC, Quinn, D, Dolan, F, Analysis of prolapse in cardiovascular stents: a constitutive equation for vascular tissue and finite element modelling, Journal of Biomechanical Engineering , 125, 2003, p692-699
Non-Peer-Reviewed Publications
Alix Whelan, Robert Gaul, Paul Gunning, Caitriona Lally, Investigation of Collagen Fibre Orientation in Bovine Pericardium, Proceedings of the 23rd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Belfast, 20/01/17, 2017
Robert Gaul, Caitriona Lally, Strain mediated enzyme degradation of arterial tissue characterised by small angle light scattering, Proceedings of the 23rd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland., Belfast, Ireland, 2017
Robert Gaul, Caitriona Lally, Load induced changes in collagen fibre architecture in arteries characterised by small angle light scattering, Proceedings of the 22nd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2016
Robert Gaul, Caitriona Lally, The use of small angle light scattering for the characterisation of collagen fibre orientation in arteries, Proceedings of the 21st Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Kildare, Ireland, 2015
Simulation of in-stent restenosis for the design of cardiovascular stents in, G. Holzpafel & R. Ogden , Mechanics of Biological Tissue, Springer, 2006, pp255 - 267, [Lally, C, Prendergast, PJ]
Recognition
Representations
Research Committee Member
Awards and Honours
ERC Starting Grant
Senior author on research paper which was awarded 2nd prize for the Engineers Ireland - IMECHE Young Engineers Research Award
Career Start Grant (DCU)
Royal Society of Medicine in Ireland, 1st prize for best student paper
Royal Society of Medicine in Ireland, 2nd prize for best student paper
Bernard Crossland Symposium, 2nd prize for best student paper
Sylvestor O'Halloran Surgical Meeting, 1st prize in poster presentation
Memberships
Member of the Institution of Engineers of Ireland (MIEI) and member of the committee for the Biomedical Division of the IEI (2006-2009) Member of the Royal Academy of Medicine of Ireland (RAMI) and the European Society of Biomechanics. PI in the Trinity Centre for Bioengineering