Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



Dr. Aisling O'Halloran
Senior Research Fellow, Medical Gerontology

Biography

Dr. O'Halloran is a Senior Research Fellow and Biobank Manager with The Irish Longitudinal StuDy on Ageing (TILDA) within the academic unit of Medical Gerontology at Trinity College Dublin and Mercer's Institute for Successful Ageing (MISA) at St. James's Hospital, Dublin. She has been the research lead on both the Frailty and Biomarker Working Groups within TILDA and also manages the TILDA Biobank, the largest of its kind in the Rep. of Ireland. Dr. O'Halloran holds a PhD in the genetic epidemiology of cardiovascular disease from the Royal College of Surgeons in Ireland and a B.A. (Mod) in Natural Science, specializing in Genetics, from Trinity College Dublin. For over fourteen years, Dr. O'Halloran has conducted research on studies of ageing, health epidemiology, immunology and genetics. Her research interests are in the area of frailty and ageing biology in older adults, including related risk factors (biomarkers) and patterns of service use. She has secured a combined peer-reviewed grant portfolio of €1.7 million, including a NIH, SFI and HRB sponsored awards. She has published >30 peer-reviewed articles in international journals. Dr. O'Halloran is also a member of the Executive Committee of the Irish Gerontological Society (IGS) and Associate Editor with the international open access journal BMC Geriatrics.

Publications and Further Research Outputs

Peer-Reviewed Publications

Fiorito, G., Polidoro, S. Dugue, P.A., Kivimaki, M., Ponzi, E., Matullo, G., Guarrera, S., Assummaa, M.B. Georgiadis, P., Kyrtopoulos, S.O. Krogh, V. Palli, D., Panico, S., Sacerdote, C. Tumino, R., Chadeau-Hyam, M., Stringhini, S., Severi, G., Hodge, A.M., Giles, G.G., Marioni, R., Linnér, R.K. O'Halloran, A., Kenny, R.A., Layte, R., McCrory, C., Baglietto, L., Milne, R.L., Vineis, P. (2017)., Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation., Scientific Reports, 7, (1), 2017, p16391 - 16395 Journal Article, 2017 URL TARA - Full Text DOI

Moran R, Beatty S, Stack J, O'Halloran AM, Feeney J, Akuffo KO, Peto T, Kenny RA, Nolan JM., The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample., Current eye research, 2017, p383-390 Journal Article, 2017 DOI TARA - Full Text

Roe LD, Normand C, Wren MA, Browne J, O'Halloran AM., The impact of frailty on healthcare utilisation in Ireland: evidence from the Irish Longitudinal Study on Ageing. , BMC Geriatrics, 17, (203), 2017 Journal Article, 2017 DOI

Feeney J, O'Leary N, Moran R, O'Halloran AM, Nolan JM, Beatty S, Young IS, Kenny RA. , Plasma Lutein and Zeaxanthin Are Associated With Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults: Findings from The Irish Longitudinal Study on Aging., The journals of gerontology. Series A, Biological sciences and medical sciences, Jan, 2017, p1-6 Journal Article, 2017 URL DOI

Moran R, Nolan J.M, Stack J, O'Halloran A.M, Feeney J, Akuffo K.O, Kenny R.A, Beatty S, Non-dietary correlates and determinants of plasma lutein and zeaxanthin concentrations in the Irish population, The journal of nutrition, health & aging, 21, (3), 2017, p254 - 261 Journal Article, 2017 URL DOI

Murphy C, Shelley E, O Halloran AM, Fahey T, Kenny RA. , Failure to control hypercholesterolaemia in the Irish adult population: Cross-sectional analysis of the baseline wave of The Irish Longitudinal Study on Ageing (TILDA). , Irish Journal of Medical Science, 2017, p1-9 Journal Article, 2017 DOI URL TARA - Full Text

Leahy S, O' Halloran AM, O' Leary N, Healy M, McCormack M, Kenny RA, O' Connell J., Prevalence and correlates of diagnosed and undiagnosed type 2 diabetes mellitus and pre-diabetes in older adults: Findings from the Irish Longitudinal Study on Ageing (TILDA)., Diabetes research and clinical practice., 110, (3), 2015, p241 - 249 Journal Article, 2015 URL DOI

Theou O, O'Connell MDL, King-Kallimanis BL, O'Halloran AM, Rockwood K, Kenny RA., Measuring Frailty using Self-report and Test-based Health Measures., Age and Aging, 44, (3), 2015, p471-7 Journal Article, 2015 DOI TARA - Full Text

Peklar J, O'Halloran AM, Maidment ID, Henman MC, Kenny RA, Kos M. , Sedative load and frailty among community-dwelling population aged ≥65 years. , Journal of the American Medical Directors Association, 16, (4), 2014, p282 - 289 Journal Article, 2014 DOI

Owusu Akuffo K, Nolan J, Stack J,Moran R, Feeney J,Kenny RA, Peto T, Dooley C, O'Halloran AM, Cronin C, and Beatty S. , Prevalence of age-related macular degeneration in the Republic of Ireland. , British Journal of Ophthalmology, 99, 2015, p1037-1044 Journal Article, 2015 DOI TARA - Full Text

Greene BR, Doheny EP, O'Halloran AM, Kenny RA., Frailty status can be accurately assessed using inertial sensors and the TUG test. , Age and Ageing, 43, (3), 2014, p406 - 411 Journal Article, 2014 TARA - Full Text URL DOI

O'Halloran AM, Finucane C, Savva GM, Robertson IH, Kenny RA., Sustained Attention and Frailty in the Older Adult Population., Journals of Gerontology B Psychological Sciences and Social Sciences. , 69, (2), 2014, p147 - 155 Journal Article, 2014 DOI

O'Halloran AM, Kenny, RA, King-Kallimanis BL. , The latent factors of depression from the short forms of the CES-D are consistent, reliable and valid in community-living older adults. , European Geriatric Medicine, 5, (2), 2014, 97-102 Journal Article, 2014 DOI TARA - Full Text

O'Halloran AM, Fan CW, Kenny RA, Pénard N, Galli A, Robertson IH., Variability in sustained attention and risk of frailty., Journal of the American Geriatric Society, 59, (12), 2011, p2390 - 2392 Journal Article, 2011 DOI URL

O'Halloran AM, Pénard N, Galli A, Fan CW, Robertson IH, Kenny RA, Falls and falls efficacy: the role of sustained attention in older adults., BMC geriatrics, 11, (85), 2011, p10 Journal Article, 2011 URL TARA - Full Text DOI

Ryan MT, O'Halloran AM, Hamill, RM, Davey, GC, Gil M, Southwood OI, Sweeney T. , Polymorphisms in the regulatory region of the porcine MYLPF gene are related to meat 3 quality traits in the Large White breed., Meat Science, 113, 2016, p104 - 106 Journal Article, 2016 URL DOI

Sweeney T, O'Halloran AM, Hamill RM, Davey GC, Gil M, Southwood OI, Ryan MT., . Novel variation in the FABP3 promoter and its association with fatness traits in pigs., Meat Science, (100), 2014, p32 - 40 Journal Article, 2014 DOI

Ryan MT, Hamill RM, O'Halloran AM, Davey GC, McBryan J, Mullen AM, McGee C, Gispert M, Southwood OI, Sweeney T, SNP variation in the promoter of the PRKAG3 gene and association with meat quality traits in pig., BMC Genetics, 13, (66), 2012, p17 Journal Article, 2012 TARA - Full Text DOI URL

O'Halloran AM, Patterson CC, Horan P, Maree A, Curtin R, Stanton A, McKeown PP, Shields DC., Genetic polymorphisms in platelet-related proteins and coronary artery disease: investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2)., Journal of Thrombosis and Thrombolysis, 27, (2), 2009, p175 - 184 Journal Article, 2009 URL DOI

O'Halloran AM, Curtin R, O'Connor F, Dooley M, Fitzgerald A, O'Brien JK, Fitzgerald DJ, Shields DC., The impact of genetic variation in the region of the GPIIIa gene, on Pl expression bias and GPIIb/IIIa receptor density in platelets., British Journal of Haematology, 132, (4), 2006, p494 - 502 Journal Article, 2006 DOI URL

O'Halloran AM, Stanton A, O'Brien E, Shields DC., The impact on coronary artery disease of common polymorphisms known to modulate responses to pathogens., Annals of Human Genetics, 70, (6), 2006, p934 - 945 Journal Article, 2006 URL DOI

Dolan C, O'Halloran A, Bradley DG, Croke DT, Evans A, O'Brien JK, Dicker P, Shields DC., Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish population., European Journal of Human Genetics, 13, (7), 2005, p798 - 806 Journal Article, 2005 DOI

Shields DC, O'Halloran AM., Integrating genotypic data with transcriptomic and proteomic data., Comparative and Functional Genomics, 3, (1), 2002, p22 - 27 Review Article, 2002 TARA - Full Text DOI URL

O'Halloran AM, Laird EA, Healy M, Moran R, Nolan J et al, CIRCULATING BIOMARKERS PREDICT INCIDENT FRAILTY: THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA) , Innovation in Aging, 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, San Fransisco, 23-27 July 2017, 1, (1 supplemental), Oxford Academic, 2017, pp23 - 23 Published Abstract, 2017 DOI

Donoghue O, Setti A, O'Leary N, O'Halloran AM, Kenny R., SELF-REPORTED UNSTEADINESS PREDICTS FEAR-RELATED ACTIVITY RESTRICTION AT TWO YEARS FOLLOW-UP , Innovation in Aging, 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, San Fransisco, 23-27 July 2017, 1, (1 supplemental), Oxford Academic, 2017, pp927 - 928 Published Abstract, 2017 DOI

Roe LD, O'Halloran AM, Kenny R, Normand C., SUPPORTING OLDER PEOPLE TO AGE IN PLACE IN IRELAND: FRAILTY-RELATED HEALTH CARE USE AND OUTCOMES , Innovation in Aging, 21st International Association of Gerontology and Geriatrics (IAGG) World Congress, San Fransisco, 23-27 July 2017, 1, (1 supplemental), Oxford Academic, 2017, pp1056 - 1056 Published Abstract, 2017 DOI

O'Halloran AM, Laird E, Healy M, Moran R, Beatty S, Nolan J, Molloy AM, Kenny RA. , Circulating Blood Biomarkers In Older Adults With Frailty: The Irish Longitudinal Study on Ageing (TILDA)., Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii13 - ii56 Published Abstract, 2016 DOI URL

O'Halloran AM, Laird E, Healy M, Moran R, Beatty S, Nolan J, Molloy AM, Kenny RA., Prevalence Of Micronutrient, Inflammatory Stress, Metabolic And Renal Conditions In Frail Older Adults: The Irish Longitudinal Study on Ageing (TILDA). , Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii13 - ii56 Published Abstract, 2016 URL DOI

Moran R, Nolan J, Stack J, O'Halloran AM, Feeney J, Akuffo KO, Kenny RA, Beatty S. , Relationship Between Prevalence (And Awareness)Of Age-Related Macular Degeneration And Plasma Concentrations Of Lutein And Zeaxanthin In An Older Population., Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii13 - ii56 Published Abstract, 2016 DOI URL

Roe L, O'Halloran AM, Normand C., The Evaluation of the Older People Remaining At Home (Oprah) Project: A Mixed Methods Study., Age and Ageing, Irish Gerontological Society (IGS) 64th Annual Scientific Meeting, Killarney, Kerry, Ireland, 29 Sept - 1st Oct, 45, (S2), Oxford University Press, 2016, ppii1 - ii12 Published Abstract, 2016 URL DOI

O'Halloran AM, Roe L, Kenny RA and Normand C., The impact of different measures of frailty on rates of health service use among the community dwelling elderly., Journal of Frailty and Aging, 3rd International Congress of Frailty and Sarcopenia Research (ICFSR), Boston, USA, 23-25 April, 4, (S1), 2015, pp46- Published Abstract, 2015

O'Halloran AM, Bressan J, King-Kallimanis BL, O'Connell MDL, Fagan J, Keenan E, Barry J, Kenny RA. , Frailty Is A Marker of Premature Biological Ageing: Preliminary Evidence from The Irish Longitudinal Study of Ageing and a Community-based Methadone Treatment Program., Journal of Frailty and Aging, 3rd International Congress of Frailty and Sarcopenia Research (ICFSR), Boston, USA, 23-25 April, 4, (S1), 2015, pp79- Published Abstract, 2015

O'Halloran AM, King-Kallimanis BL, O'Connell MDL, Robertson IH, and Kenny RA., Sustained attention correlates with two models of frailty At baseline and follow-up: the irish longitudinal study of ageing., Journal of Frailty and Aging, International Conference of Frailty and Sarcopenia Research, Barcelona, Spain, March 12-14, edited by Cesari M , 3, (1), Serdi Edition, 2014, pp34 - 34 Published Abstract, 2014 URL TARA - Full Text

Peklar, J, O'Halloran AM, Kos M, Henman MC, Maidment I, Kenny RA, Frailty syndrome and sedative load of drugs, Journal of Frailty and Aging, International Conference on Frailty and Sarcopenia Research, Barcelona, Spain, March 12-14, edited by Cesari M , 3, (1), Serdi Edition, 2014, pp54 - 54 Published Abstract, 2014 URL TARA - Full Text

O'Halloran, A.M., Kenny, R.A., King-Kallimanis, B.L., The Factor Structure of the Long and Short Forms of the CES-D Scale and the Validity of Positive Affect in Older Irish Adults., Age and Ageing, British Geriatric Society (BGS), Spring Meeting, Belfast, UK, April 18-19, 2013, edited by Stott, DJ , 45, (S3), Oxford Journals, 2013, ppii27- Published Abstract, 2013 TARA - Full Text URL URL

O'Halloran, A.M., Kallimanis, B.L., Kenny, R.A. , The Impact of Positive Affect on Falls and Fear of Falling in the Older Adult Population. , Age and Ageing, British Geriatric Society (BGS), Annual Meeting, Harrogate, UK, November 28-30, 2012, edited by Stott, DJ , 42, (S2), Oxford Journals, 2013, ppii20- Published Abstract, 2013 TARA - Full Text URL

O'Halloran, A.M., O'Connell, M.D.L., Finucane, C., Savva, G.M., Robertson, I.H., Kenny, R.A. , The Relationships Between Executive Function, Cognitive Processing Speed And Two Models of Frailty Are Mediated By Sustained Attention In The Older Adult Population. , European Geriatric Medicine, 8th Congress of the European Union Geriatric Medicine Society (EUGMS), Venice, Italy, October 2-4, edited by Michel, J-P , 4, (S1), Elsevier, 2013, ppS70- Published Abstract, 2013 TARA - Full Text URL

O'Halloran, A.M., Treacy, K., Cunningham, C., Crosby, L., Walsh, C., Fan, C.W., Kenny, R.A. , The Impact of Positive Affect on Falls Efficacy in the Older Adult Population. , European Geriatric Medicine, 8th Congress of the European Union Geriatric Medicine Society (EUGMS), Brussels, Belgium, September 26-28, edited by Michel, J-P , 3, (S1), Serdi Edition, 2012, ppS137- Published Abstract, 2012 URL TARA - Full Text URL

O'Halloran, A.M., Finucane, C., Savva, G.M., Robertson, I.H., Kenny, R.A. , Sustained Attention Is Associated With Frailty In The Older Adult Population. , European Geriatric Medicine, 8th Congress of the European Union Geriatric Medicine Society (EUGMS), Brussels, Belgium, September 26-28, edited by Michel, J-P , 3, (S1), Serdi Edition, 2012, ppS16- Published Abstract, 2012 URL TARA - Full Text

Laird, E. and O'Halloran, A.M. and Carey, D. and Healy, M. and O'Connor, D. and Moore, P. and Shannon, T. and Molloy, A.M. and Kenny, R.A., The Prevalence of Vitamin D Deficiency and the Determinants of 25(OH)D Concentration in Older Irish Adults: Data from the Irish Longitudinal Study on Ageing (TILDA), Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73, (4), 2018, p519-525 Journal Article, 2018 DOI

Connolly E, Rhatigan M, O'Halloran AM, Muldrew KA, Chakravarthy U, Cahill M, Kenny RA, Doyle SL., Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population, British Journal of Ophthalmology, 102, (12), 2018, p1691 - 1695 Journal Article, 2018 DOI URL

Wong TY, Massa MS, O'Halloran AM, Kenny RA, Clarke R., Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention., Age and ageing, 47, (5), 2018, p714-720 Journal Article, 2018 TARA - Full Text DOI

Laird EJ, O'Halloran AM, Carey D, O'Connor D, Kenny RA, Molloy AM, Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA)., The British journal of nutrition, 2018, p111 - 120 Journal Article, 2018 TARA - Full Text

Briggs R, McCarroll K, O'Halloran A, Healy M, Kenny RA, Laird E, Vitamin D Deficiency Is Associated With an Increased Likelihood of Incident Depression in Community-Dwelling Older Adults., Journal of the American Medical Directors Association, 20, (5), 2019, p517 - 523 Journal Article, 2019 URL DOI

Briggs R, Carey D, O'Halloran A, Kenny RA, Kennelly SP, Validation of the 8-item Centre for Epidemiological Studies Depression Scale in a cohort of community-dwelling older people: data from The Irish Longitudinal Study on Ageing (TILDA) , European Geriatric Medicine, 9, (1), 2018, p121-126 Journal Article, 2018 URL DOI

O'Halloran AM, Laird EJ, Feeney J, Healy M, Moran R, Beatty S, Nolan FM, Molloy AM, Kenny RA. , Circulating micronutrient biomarkers are associated with three measures of frailty: Evidence from The Irish Longitudinal Study on Ageing (TILDA). , JAMDA, 2019 Journal Article, 2019 DOI TARA - Full Text

Feeney JC, O'Halloran AM, Kenny RA., The Association Between Hair Cortisol, Hair Cortisone, and Cognitive Function in a Population-Based Cohort of Older Adults: Results From The Irish Longitudinal Study on Ageing., The journals of gerontology. Series A, Biological sciences and medical sciences, 75, (2), 2020, p257-265 Journal Article, 2020 DOI

Laird EJ, McNicholas T, O'Halloran AM, Healy M, Molloy AM, Carey D, O'Connor D, McCarroll K, Kenny RA., Vitamin D Status Is Not Associated With Orthostatic Hypotension in Older Adults., Hypertension (Dallas, Tex. : 1979), 74, (3), 2019, p639-644 Journal Article, 2019 DOI

Romero-Ortuno R, Scarlett S, O'Halloran AM, Kenny RA., Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in TILDA., Age and ageing, 2019 Journal Article, 2019 DOI TARA - Full Text

Laird E, O'Halloran AM, Fedorowski A, Melander O, Hever A, Sjögren M, Carey D, Kenny RA., Orthostatic hypotension and novel blood pressure associated gene variants in older adults: data from the TILDA Study., The journals of gerontology. Series A, Biological sciences and medical sciences, 2019 Journal Article, 2019 DOI TARA - Full Text

McCrory C, McLoughlin S, O'Halloran AM, Socio-Economic Position Under the Microscope: Getting 'Under the Skin' and into the Cells, Current Epidemiology Reports, 6, (4), 2019, p403 - 411 Journal Article, 2019 DOI URL

BMC Geriatrics, Springer Nature, [Associate Editor.], 2018-2020 Editorial Board, 2018

O'Connor DMA, Laird EJ, Carey D, O'Halloran AM, Clarke R, Kenny RA, Molloy AM., Plasma concentrations of vitamin B12 and folate and global cognitive function in an older population: Cross-sectional findings from The Irish Longitudinal Study on Ageing (TILDA)., The British journal of nutrition, 2020, p1-25 Journal Article, 2020 DOI

Ward, M; Turner, N; Briggs, R; O'Halloran, A M; Kenny, R A, Resilience does not mediate the association between Adverse Childhood Experiences and later life depression. Findings from The Irish Longitudinal Study on Ageing (TILDA), Journal of Affective Disorders, 2020 Journal Article, 2020 DOI

McCrory C, Fiorito G, Hernandez B, Polidoro S, O'Halloran AM, Hever A, Ni Cheallaigh C, Lu AT, Horvath S, Vineis P, Kenny RA., GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality., The Journals of Gerontology. Series A, Biological sciences and medical sciences, 76, (5), 2021, p741 - 749 Journal Article, 2021 DOI

Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Deirdre O'Connor, Román Romero Ortuño, Rose Anne Kenny, An examination of the prevalence of metabolic syndrome in older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing (TILDA), PLOS ONE, 2022 Journal Article, 2022 DOI

Caoileann H. Murphy, Eoin Duggan, James Davis, Aisling M. O'Halloran, Silvin P. Knight, Rose Anne Kenny, Sinead N. McCarthy, Roman Romero-Ortuno, Plasma lutein and zeaxanthin concentrations associated with musculoskeletal health and incident frailty in The Irish Longitudinal Study on Ageing (TILDA), Experimental Gerontology, 2022 Journal Article, 2022 TARA - Full Text DOI

Ward M, Briggs R, McGarrigle CA, De Looze C, O'Halloran AM, Kenny RA., The bi-directional association between loneliness and depression among older adults from before to during the COVID-19 pandemic., International journal of geriatric psychiatry, 38, (1), 2023, pe5856 Journal Article, 2023 DOI

Eoin Duggan, Caoileann H. Murphy, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing, Journal of Gerontology: Medical Sciences, 2022 Journal Article, 2022 DOI TARA - Full Text

Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Román Romero Ortuño, Rose Anne Kenny, Association between metabolic syndrome and risk of both prevalent and incident frailty in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA), Experimental Gerontology, 2022 Journal Article, 2022 DOI

O'Connor D., Molloy A.M., Laird E., Kenny R.A., O'Halloran A.M., Sustaining an ageing population: The role of micronutrients in frailty and cognitive impairment, Proceedings of the Nutrition Society, 2023 Journal Article, 2023 DOI

Peter Hartley, Faye Forsyth, Aisling O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, Eight-year longitudinal falls trajectories and associations with modifiable risk factors: evidence from The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2023 Journal Article, 2023 DOI TARA - Full Text

Nowak N, De Looze C, O'Halloran A, Kenny RA, Sexton DJ., The association between kidney function, cognitive function, and structural brain abnormalities in community-dwelling individuals aged 50"+"is mediated by age and biomarkers of cardiovascular disease., Cardiovascular research, 2023, pcvad060 Journal Article, 2023 DOI

Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023 Journal Article, 2023

McCrory, C., McLoughlin, S., Layte, R., Ni Cheallaigh, C., O'Halloran, A.M, Barros, H., Berkman, L.F., Bochud, M., Crimmins, E., Farrell, M., Fraga, S., GrundyE., Kelly-Irving, M., Petrovic, D., Seeman, T., Stringhini, S., Vollenveider, P., Kenny, R.A, Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD ) meta-analysis, Psychoneuroendocrinology, 2023 Journal Article, 2023

Laird Eamon, O'Halloran Aisling M, Molloy Anne M, Healy Martin, Bourke Nollaig, Kenny Rose Anne, Vitamin D status & associations with inflammation in older adults , PloS one , 18 , (6 ), 2023, pe0287169 - Journal Article, 2023 DOI URL

McCarthy K, O'Halloran AM, Fallon P, Kenny RA, McCrory C., Metabolic syndrome accelerates epigenetic ageing in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA)., Experimental gerontology, 183, 2023, p112314 Journal Article, 2023 DOI TARA - Full Text

Chenhuichen, C. and O†Halloran, A.M. and Lang, D. and Kenny, R.A. and Romero-Ortuno, R., The lived experience of frailty: beyond classification and towards a holistic understanding of health, European Geriatric Medicine, 2024 Journal Article, 2024 DOI

Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O"Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA), Sensors, 2024 Journal Article, 2024 URL TARA - Full Text DOI

De Looze C, McCrory C, O'Halloran A, Polidoro S, Anne Kenny R, Feeney J., Mind versus body: Perceived stress and biological stress are independently related to cognitive decline. , Brain, behavior, and immunity, 2023, pS0889-1591(23)00322-7 Journal Article, 2023 DOI

Laura Orlandini, Enrica Patrizio, Aisling M O'Halloran, Christine A McGarrigle, Roman Romero Ortuno, Rose Anne Kenny, Marco Proietti, Matteo Cesari, Social vulnerability, frailty and self-perceived health: findings from The Irish Longitudinal Study on Ageing (TILDA), The Journal of Frailty & Aging, 2024 Journal Article, 2024 DOI

O'Halloran A.M., Cremers J., Vrangbaek K., Roe L., Bourke R., Mortensen L.H., Westendorp R.G.J., Kenny R.A., Cardiovascular disease and the risk of incident falls and mortality among adults aged " 65 years presenting to the emergency department: a cohort study from national registry data in Denmark, BMC Geriatrics, 24, (1), 2024 Journal Article, 2024 DOI

Kim D.J., Massa M.S., Clarke R, Scarlett S, and O'Halloran A.M., Kenny R.A., and Bennett, D, Variability and agreement of frailty measures and risk of falls, hospital admissions and mortality in TILDA, Scientific Reports, 12, (1), 2022 Journal Article, 2022 DOI TARA - Full Text

Palina Piankova, Roman Romero-Ortuno, Aisling M O'Halloran, Biomarker Signatures of Two Phenotypical Pre-Frailty Types in The Irish Longitudinal Study on Ageing, Geriatrics (Basel), 2022 Journal Article, 2022 TARA - Full Text URL DOI

O'Donoghue, P. and O'Halloran, A.M. and Kenny, R.A. and Romero-Ortuno, R., Do the frail experience more adverse events from intensive blood pressure control? A 2-year prospective study in the Irish Longitudinal Study on Ageing (TILDA), eClinicalMedicine, 45, (101304), 2022 Journal Article, 2022 DOI

Georgia Richard, Aisling O'Halloran, Paul Doody, Joseph Harbison, Rose Anne Kenny, Roman Romero-Ortuno, Atrial Fibrillation and Acceleration of Frailty: Findings from The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2021 Journal Article, 2021 DOI

O'Connor DMA, Scarlett S, De Looze C, O'Halloran AM, Laird E, Molloy AM, Clarke R, McGarrigle CA, Kenny RA., Low folate predicts accelerated cognitive decline: 8-year follow-up of 3140 older adults in Ireland., European journal of clinical nutrition, 76, (7), 2022, p950 - 957 Journal Article, 2022 DOI

McCrory C, Fiorito G, O'Halloran AM, Polidoro S, Vineis P, Kenny RA., Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks., Psychoneuroendocrinology, 137, 2021, p105643 Journal Article, 2021 DOI

Non-Peer-Reviewed Publications

O'Halloran, AM, Recognising Frailty: Insights from The Irish Longitudinal Study on Ageing (TILDA)., : Integrated Care Approach for Frailty in the Older Person Conference. , Galway, Ireland, March 8th , 2017, Health Service Executive and Saolta Hospital Group, 1pp Invited Talk, 2017

Daniel Carey, Orna Donoghue, Sarah Gibney, Joanne Feeney, Rose Anne Kenny, Eamon Laird, Christine McGarrigle, Sinead McLoughlin, Triona McNicholas, Irene Mosca, Charles Normand, Aisling O'Halloran, Mary O'Shea, Lorna Roe, Siobhan Scarlett, Katie Tobin, Stephen Thomas, Dominic Trepel, Niall Turner, Mark Ward, Wellbeing And Health In Ireland's Over 50s 2009-2016. , Dublin, Ireland, The Irish Longitudinal Study on Ageing 2018, November, 2018 Report, 2018 URL

Roe L, O'Halloran AM, Normand C, Murphy C., The impact of frailty on public health nurse service utilisation. Findings from The Irish Longitudinal Study on Ageing (TILDA). , Dublin, Ireland, The Irish Longitudinal Study on Ageing., September, 2016, 1-28 Report, 2016 URL

Aisling M. O'Halloran, Falls and Frailty in Ireland - Evidence from the Irish Longitudinal Study on Ageing (TILDA), AGM of Chartered Physiotherapists of Ireland in Neurology and Gerontology, Dublin, Ireland, May 17, 2014, Chartered Physiotherapists of Ireland Invited Talk, 2014

Aisling O'Halloran, Mature Matters: Ageing, 2012, - 1 Miscellaneous, 2012 URL TARA - Full Text

O'Halloran AM, Frailty and Falls in Ireland North and South: Preliminary Evidence from TILDA and NICOLA. , Joint Public Health Conference. , Belfast, UK, 8th November, 2018, Public Health Agency Northern Ireland and Health Service Executive Invited Talk, 2018

O'Halloran AM, Targeting Frailty to Prevent Disability: Insights from The Irish Longitudinal Study on Ageing (TILDA). , National Disability Authority Annual Conference, Dublin, Ireland, 25th September, 2018, National Disability Authority Invited Talk, 2018

Tools for Assessing Frailty in Older People: General Concepts. in, editor(s)Nicola Veronese , Frailty and Cardiovascular Diseases, Switzerland, Springer, Cham, 2020, pp9 - 19, [Martin FC, O'Halloran AM.] Book Chapter, 2020 DOI URL

O'Halloran AM, Frailty in Ireland - A developing landscape, Paul Wagstaff Commemorative Lecture, Dublin, Ireland, 9th September , 2019, Irish Society of Chartered Physiotherapists Invited Talk, 2019

Research Expertise

Description

Her current research interest is in the biology of ageing, including frailty, falls, resilience and well-being. She has a particular interest in characterizing biomarkers (genes, proteins, metabolites, processes) implicated in these age-related disorders. The goal of her research is to identify early biomarkers for use in screening and intervention in the progression of frailty and investigate patterns of health care use. This work will inform frailty detection/prevention/intervention, frailty-related health service use and provision and raise public awareness of frailty on the island of Ireland.

Projects

  • Title
    • Frailty-related Outcomes and health Care USe (FOCUS)
  • Funding Agency
    • Health Service Executive (HSE)
  • Date From
    • February 2016
  • Date To
    • July 2017
  • Title
    • Frailty in Ireland North and South
  • Summary
    • The unprecedented global increase in life expectancy over the past century has lead to a rapidly expanding ageing population, placing ever higher demands on publicly-funded healthcare resources in Ireland, North and South. Current trajectories indicate that such demands are unsustainable. Early identifiers of declining health will be central to measuring health risk. The European Innovation Partnership on Active and Healthy Ageing has highlighted frailty as key to seeking a two year increase in healthy life years by 2020. Resilience and frailty represent opposite ends of a spectrum of decline from robust health to profound functional dependence. Frailty is a driver of functional and cognitive decline, predicting multi-morbidity, disability, increased health care utilisation and mortality (Fried et al, 2001, 2004). However, frailty can be ameliorated by early detection and intervention. Data from The Irish Longitudinal Study of Ageing (TILDA) will be used to track transitions along the frailty spectrum and investigate how frailty-related biomarker profiles of physical, cognitive and psychological health at baseline (Wave 1) change and predict frailty during follow-up (Waves 2 and 3). North-South comparisons between the prevalence and characteristics of frailty using Wave 3 of TILDA and Phase 1 of the Northern Ireland Cohort for Longitudinal Ageing (NICOLA), which coincide during 2014. Will be performed. Elucidating frailty-related risk factors and resource demands in the ageing population will help to identify: (1) new evidence-based targets for pre-clinical frailty detection and intervention, and (2) specific needs that will be vital in delivering efficient, effective healthcare services and increasing healthy life-years into the future
  • Funding Agency
    • CARDI - Centre for Ageing Research in Ireland
  • Date From
    • March 2014
  • Date To
    • February 2017
  • Title
    • The Irish Longitudinal Ageing Study (TILDA) Nutritional Biomarker Database Enhancement Initiative (BIO-TILDA)
  • Funding Agency
    • Dept. of Agriculture, Food and Marine (DARM)
  • Date From
    • January 2014
  • Date To
    • January 2016

Keywords

AFFECT; Age related diseases; Ageing; Ageing, memory and other cognitive processes; Ageing, stroke, dementia; Aging/Gerontology; Brain; Cardiovascular Diseases; Cardiovascular System; Elderly Health; Emotional/Mental Health--Geriatric; Epidemiology; Falls; Frailty & Resilience; Gerontology; Positive Ageing; Psychology of Aging; Quantitative genetics and genetics of complex traits

Recognition

Awards and Honours

Best Abstract Award at Falls Frailty and Bone Health Europe Conference, Dublin. 10/11/2017

Best Presentation Medal at Irish Gerontological Society Annual Scientific Meeting, Kilarney 01/10/2016

CARDI Ageing Research Leadership March 2014

Department of Agriculture Fisheries and the Marine (DAFM) FIRM/RSF/CoFoRD 2013 Research Award December 2013

Best Research Presentation. Medical Gerontology Annual Research Meeting, Trinity College, Dublin March 2012

Commendation Award for Scientific Presentation at Irish Gerontological Society Annual (IGS) Scientific Meeting, Dublin September 2011

America-Ireland Fund Undergraduate Scholarship Award, Smurfit Institute of Genetics, Trinity College Dublin and School of Medicine, Washington University, St. Louis, Missouri, USA May 1998

Memberships

Irish Gerontological Society Member of Executive Committee (2016 - present) 2010- – present

Irish Frailty Network (IFN) - Founding Member 2019 – present

British Geriatrics Society (BGS) 2012-

European Union Geriatric Medicine Society (EUGMS) 2012-

National Institute of Ageing (NIA) Biomarker Network. 2013-

Irish Society of Immunology 2012-

Gerontological Society of America (GSA) 2016