Dr. Friedrich Wetterling
Assistant Professor, Electronic & Elect. Engineering
Biography
Assistant Professor for Biomedical Circuits and Systems at Trinity College and head of The MediCAS Lab, a position anchored at the Department of Electronic and Electrical Engineering within the School of Engineering. He led the radio-frequency and system development of an innovative implantable device for congestive heart failure monitoring at FIRE1 (2016-2024). He was a Marie-Curie Research Fellow at Trinity College where he developed a novel monitoring method for cardiac function using inductively coupled resonators, i.e. radio-frequency cardiography (2013-2015). Prior to that he led the Magnetic Resonance Methods and Imaging group at the Chair for Computer Assisted Clinical Medicine, Heidelberg University (2009-2012) where his team captured the first whole body tomographic image set solely based upon the local sodium concentration in a human. In 2010, he was awarded the Siemens Prize for establishing Sodium-23 Magnetic Resonance Imaging for stroke tissue viability assessment at the annual meeting of the German Medical Physics Association (DGMP) in Freiburg, Germany. He is a member of the International Society for Magnetic Resonance in Medicine (ISMRM). He has authored and co-authored over 40 publications in peer-reviewed scientific journals and conferences papers. And he has authored more than 30 patent applications. Dr. Friedrich Wetterling is head of the Medical Circuits and Systems Lab (MediCAS) at the department of Electronics and Electrical Engineering where he and his team are researching and developing: - #accessible devices that are remotely deployable using portable, wearable, and implantable circuits - #sustainable systems that reduce the need of finite resources such as helium - #meaningful solutions offering physiologically-relevant and accurate measurements to monitor and to manage chronic health conditions
Publications and Further Research Outputs
Peer-Reviewed Publications
Leah Su Whelan, Ilaria Facchi, Isaac Tobin, Shane Hunt, Conor Conway, Dhanya Krishnakumar, Marat Fudim, Friedrich Wetterling, Influence of Dielectric Loading on the Resonant Response of an Implantable LC Pulmonary Artery Pressure Sensor, IEEE Xplore, Engineering in Medicine and Biology Society, 2026, p1 - 7
Conor Conway, Isaac Tobin, Shane Hunt, Leah Su Whelan, Friedrich Wetterling, Design and Implementation of a Three-Axis Gradient System for Earth's Field Magnetic Resonance Imaging of Cardiac Tissue in the City-Centre of Dublin, IEEE Xplore, Engineering in Medicine and Biology Society, 2026, p1 - 7
Grace Whelan, Kate Connor, Friedrich Wetterling, Pre-clinical low-field MRI at 0.55T: signal enhancement through gadolinium and manga- nese contrast agents for ex vivo mouse brain imaging, British and Irish Chapter of the International Society for Magnetic Resonance in Medicine, London, UK, September 2026, 2026, pp50 - 51
Ilaria Facchi, AnaFlavia de Aleida Barreto, Isaac Tobin, Shane Hunt, Thomas D. O'Sullivan, Friedrich Wetterling, Passive Optical Sensing using a Zero-Biased Photodiode in a Resonant Circuit for Implantable Vascular Applications, IEEE Explore, Engineering in Medicine and Biology Society, 2026, p1 - 6
Facchi, Ilaria; Yameen, Nabhan; Barreto, Ana; O'Sullivan, Thomas; Wetterling, Friedrich, Enhancing Deep-Tissue Power Transfer through Expandable Nitinol Antenna for Vascular Implants, 2026 20th European Conference on Antennas and Propagation (EuCAP), Dublin, Ireland, 2026, p1 - 5
Friedrich Wetterling; Nagesh Shanbhag; Lothar Schilling, A Simple, but Variable Transformer-Matched Resonance Circuit for High Resolution Sodium-23 Magnetic Resonance Imaging of an In Vivo Stroke Model at 9.4T, IEEE Xplore, A Simple, but Variable Transformer-Matched Resonance Circuit for High Resolution Sodium-23 Magnetic Resonance Imaging of an In Vivo Stroke Model at 9.4T, Copenhagen, Denmark, July 2025, edited by IEEE Explore , 2025, pp1 - 5
Wetterling F, Fryc B, Facchi I, Okabe T, Heist EK, Fudim M., Subcutaneous sensors for monitoring congestion and to reduce heart failure hospitalizations-a viable middle ground between deep implantable intravascular monitoring devices and wearable technologies?, Heart Failure Reviews, 30, (5), 2025, p1113 - 1122
Friedrich Wetterling, Can Sensor Implantation Alone Reduce Heart Failure Hospitalizations Without Need for Structured Management Based on its Data?, JACC Heart Failure, 13, (12), 2025, p102721 - 102721, p102721-102721
Stephanie Gardner, Kate Connor, Jeffrey Glennon, Friedrich Wetterling, High-resolution T1-weighted magnetic resonance imaging of myelinated fibre tracts in the caudate putamen of an ex vivo murine model at 9.4T, British and Irish Chapter of the International Society for Magnetic Resonance in Medicine, Brighton, UK, September 2025, 2025, pp42 - 43
Bartlomiej Fryc, Ilaria Facchi, Maja Cikes, Ante Anic, Petr Neuzil, Vivek Reddy, Marat Fudim, Deb Kridner, Jaeson Bang, and Friedrich Wetterling, Visualizing Cardiac Motion Using Subcutaneously Measured Electrocardiography and Three-Axis Acceleration: Day-to-Day Comparability and Event-Related Changes in Congestive Heart Failure Patients, IEEE Xplore, 7th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Copenhagen, Denmark,, July 2025, edited by IEEE Xplore , 2025, pp1 - 4
Wetterling Friedrich, Conway Conor, Hunt Shane, Bokde Arun, and Kokaram Anil, Ultra-low field Magnetic Resonance Imaging of the human forearm in the Earth"s Magnetic Field of Dublin, Ireland., British and Irish Chapter of the International Society for Magnetic Resonance in Medicine, Nottingham, UK, 11-13 September 2024, 2024, pp98 - 99
Aristokleous N, Collopy D , Wetterling F., Sweeney F., O'Cearbhaill E., O"Rourke M., IN SILICO MODELLING OF FLOW-INDUCED COLLAPSE OF BLOOD VESSELS: A COMPARATIVE STUDY OF VOLUME STATUSES, 29th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (BinI 2024), Belfast, Northern Ireland, 26-27 January 2024, 2024
Wetterling Friedrich, Kittipibul Veraprapas, Fudim Marat, Measurement inaccuracy reported via the Manufacturer and User Facility Device Experience database for an implantable pulmonary artery pressure sensor: recalibration direction and magnitude results, European Heart Journal, European Society of Cardiology, London, 31 August 2024, 45, (Supplement 2), 2024, pp2
Wetterling F, Sheridan WS, Testani JM, Borlaug BA, Fudim M, Damman K, Gray A, Gaines P, Poloczek M, Madden S, Tucker J, Buxo T, Gaul R, Corcoran L, Sweeney F, Burkhoff D., Safety and performance of a novel implantable sensor in the inferior vena cava under acute and chronic intravascular volume modulation., European journal of heart failure, 25, (5), 2023, p754-763
Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, HOW INFERIOR VENA CAVA COLLAPSIBILITY INDEX FROM A NOVEL IMPLANTABLE SENSOR CORRELATES WITH ESTIMATED PLASMA VOLUME AND NT-PROBNP: A STUDY IN PATIENTS WITH CHRONIC HEART FAILURE, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1
Málek F, Došká" P, Wetterling F, Marešová Z, Reddy V, Neužil P, MONITORING OF VOLUME STATUS USING A NOVEL SENSOR FOR THE ASSESSMENT OF INFERIOR VENA CAVA AREA AND COLLAPSIBILITY IN A PATIENT WITH HFREF RECEIVING ADVANCED HEART FAILURE THERAPIES, Czech Cardiovascular Research and Innovation Days 2023, Prague, Czech Republic, 20-21 November 2023, 2023, pp1
Ivey-Miranda JB, Wetterling F, Gaul R, Sheridan S, Asher JL, Rao VS, Maulion C, Mahoney D, Mebazaa A, Gray AP, Burkhoff D, Cowie MR, Cox ZL, Butler J, Fudim M, McDonald K, Damman K, Borlaug BA, Testani JM., Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone., European journal of heart failure, 24, (3), 2022, p455-462
Wacker M, Wetterling F, Feczko T, Arkelius K, Arnou A, Lellouche J, Ansar S, Advanced theranostic nanocarrier-mediated delivery of NGF in a combination therapy trigger enhanced recovery after stroke, Journal of Cerebral Blood Flow & Metabolism, BRAIN and BRAIN-PET 2022, Glasgow, Scotland, 28 May - 1 June 2022, 42, (1S), 2022, pp263 - 264
Raikhelkar J, Kebed K, Narang A, Kruse E, Weatherford S, Imamura T., Wetterling F, Nguyen A, Sayer G, Lang R., Uriel N., Inferior Vena Cava Collapsibility Index Assessed by 3D Echocardiography: A Novel Tool for the Assessment of Right Atrial Pressure in Heart Failure Patients, Journal of the American Society of Echocardiography, 32, (6), 2019, pp130 - 131
McCarthy H., Stanley J., Piech R., Wetterling F., Skokauskas N., Mulligan A., Donohoe G., Mullins D., Kelly J., Johnson K., Fagan A., Gill M., Meaney J., Frodl T., Childhood-Diagnosed ADHD, Symptom Progression, and Reversal Learning in Adulthood, Journal of Attention Disorders, 22, (6), 2018, 561, p570
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S., Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging., Acta physiologica (Oxford, England), 223, (1), 2018, pe12985
McGroarty M., Meldrum D., Giblin S., French H.,Wetterling F., Variations in knee flexion measurements for overhead squat as measured with marker-based and markerless motion capture systems, Gait & Posture, 49, (S), 2016, p89 - 90
McGroarty M., Giblin S., Meldrum D., Wetterling F., ACCURACY OF A LOW-COST NOVEL COMPUTER-VISION DYNAMIC MOVEMENT ASSESSMENT: POTENTIAL LIMITATIONS AND FUTURE DIRECTIONS, Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci., XL-5, (W8), 2016, p1 - 5
Giblin, S., Meldrum D., McGroarty M., O'Brien S., Rand S., Smith S., Grogan K., Wetterling F., Bone length calibration can significantly improve the measurement accuracy of knee flexion angle when using a marker-less system to capture the motion of countermovement jump, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, 2016, p392-397
Wetterling F, Chatzikonstantinou E, Tritschler L, Meairs S, Fatar M, Schad LR, Ansar S., Investigating potentially salvageable penumbra tissue in an in vivo model of transient ischemic stroke using sodium, diffusion, and perfusion magnetic resonance imaging., BMC neuroscience, 17, (1), 2016, p82
Weinberger O., Winter L., Dieringer M. A., Els A., Oezerdem C., Rieger J., Kuehne A., Cassara A. M., Pfeiffer H., Wetterling F., Niendorf T., Local Multi-Channel RF Surface Coil versus Body RF Coil Transmission for Cardiac Magnetic Resonance at 3 Tesla: Which Configuration Is Winning the Game?, PLoS ONE, 11, (9), 2016, p23
Tozzi L., Carballedo A., Wetterling F., McCarthy H., O'Keane V., Gill M., Morris D., Fahey C., Meaney J., Frodl T., Single Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression., Neuropsychopharmacology, 41, 2016, p487-497
Gobbo, O.L., Wetterling, F., Vaes, P., Teughels, S., Markos, F., Edge, D., Shortt, C. M., Crosbie-Staunton, K., Radomski, M.W., Volkov, Y., Prina-Mello, A, Biodistribution and pharmacokinetic studies of SPION using particle Electron Paramagnetic Resonance, MRI and ICP-MS, Nanomedicine (Lond.), 10, 2015, p1751 - 1760
Wetterling, F., McCarthy, H., Tozzi, L., Skokauskas, N., O'Doherty J. P., Mulligan, A., Meaney, J., Fagan, A. J., Gill, M., Frodl, T., Impaired Reward Processing in the Human Prefrontal Cortex Distinguishes Between Persistent and Remittent Attention Deficit Hyperactivity Disorder, HUMAN BRAIN MAPPING, 36, (1), 2015, p4648-4663
Giblin S.,Smith M., Smith S., O'Brien S., McMorrow J. P., Meaney J., Wetterling F., Whole-Body Magnetic Resonance Imaging Enables Assessing Spatial Accuracy and Precision of Skeletal Joint Locations Inferred from Motion Capture Systems, 6th International Conference on 3D Body Scanning Technologies, Lugano, Switzerland, 27-28 October 2015, 2015, pp98 - 105
Gobbo O., Wetterling F., Vaes P., Teughels S., Markos F., Edge D., Shortt C., Crosbie-Staunton K., Radomski M., Volkov Y., Prina-Mello A., Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS, Nanomedicine, 10, (11), 2015, p1751-1760
Andreas Graessl, Anjuli Ruehle, Helmar Waiczies, Ana Resetar, Stefan H Hoffmann, Jan Rieger, Friedrich Wetterling, Lukas Winter, Armin M Nagel, Thoralf Niendorf, Sodium MRI of the human heart at 7.0 T: preliminary results, NMR in Biomedicine, 2015
Friedrich Wetterling, Lindsay Gallagher, Jim Mullin, William M Holmes, Chris McCabe, I Mhairi Macrae and Andrew J Fagan, Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time, Journal of Cerebral Blood Flow and Metabolism, 35, (1), 2015, p103 - 110
Sebastian Weingärtner, Friedrich Wetterling, Simon Konstandin, Marc Fatar, Eva Neumaier-Probst, Lothar Schad, Scan time reduction in 23Na-magnetic resonance imaging using the chemical shift imaging sequence: Evaluation of an iterative reconstruction method, ZETUNG FÜR MEDIZINISCHE PHYSIK, 2014, p1 - 11
Wetterling F, Fox EK, Brougham DF and Gobbo OL (, Earth-field magnetic resonance imaging- investigating magnetic nanoparticle contrast in ex-vivo liver, ISMRM, 2014
Sack M, Wetterling F, Sartorius A, Ende G, Weber-Fahr W, Signal-to-noise ratio of a mouse brain (13) C CryoProbe system in comparison with room temperature coils: spectroscopic phantom and in vivo results., NMR in biomedicine, 27, (6), 2014, p709-15
Danisch, Kalayciyan, Wetterling, Schad, Bilateral 23Na MR imaging of the breast and quantification of sodium concentration, ZEITUNG FUER MEDIZINISCHE PHYSIK, 24, (1), 2014, p65-72
Danisch M, Kalayciyan R, Wetterling F, Schad LR, [Bilateral 23Na MR imaging of the breast and quantification of sodium concentration]., Zeitschrift fur medizinische Physik, 2013
Gobbo OL, Wetterling F, Crosbie-Staunton K, Vaes P, Teughels S, Markos F, Radomski MW, Prina-Mello A and Volkov Y, Pharmacokinetics and biodistribution of superparamagnetic nanoparticles using pEPR in the mouse: an in vivo, in vitro and ex vivo validation, ISMRM, 2013
Wetterling, Mok, McGoldrick, Basu, Non-Destructive Investigation of Glass Fiber Reinforced Composites via Magnetic Resonance Imaging, Key Engineering Materials, 569-570, 2013, p126 - 131
Kalayciyan, Wetterling, Neudecker et al., Bilateral kidney sodium-MRI: Enabling accurate quantification of renal sodium concentration through a two-element phased array system, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2013
Wetterling et al., The design of a double-tuned two-port surface resonator and its application to in vivo hydrogen- and sodium-mri, Journal of Magnetic Resonance, 217, 2012, p10 - 18
Hausmann, Konstandin, Wetterling et al., Apparent diffusion coefficient and sodium concentration measurements in human prostate tissue via hydrogen-1 and sodium-23 mri in a clinical setting at 3T, INVESTIGATIVE RADIOLOGY, 47, (12), 2012, p677 - 682
Wetterling et al., Whole-body sodium-mri at 3 T using an asymmetric birdcage resonator and short echo time sequence: first images of a male volunteer , PHYSICS IN MEDICINE AND BIOLOGY, 57, 2012, p4555 - 4567
Hausmann D, Konstandin S, Wetterling F, Haneder S, Nagel AM, Dinter DJ, Schönberg SO, Zöllner FG, Schad LR, Apparent diffusion coefficient and sodium concentration measurements in human prostate tissue via hydrogen-1 and sodium-23 magnetic resonance imaging in a clinical setting at 3T., Investigative radiology, 2012
El-Abyad, Kalayciyan, Schad, Wetterling, Enhancing the detector sensitivity of a radio-frequency surface resonator for potassium-39 mri at 18.7 mhz: probing different geometries at various temperatures, IEEE XPLORE, 42nd European Microwave Conference, Amsterdam, 29 Oct - 1 Nov, 2012, pp444 - 7
Wetterling, Ansar, Handwerker, Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems, PHYSICS IN MEDICINE AND BIOLOGY, 57, (21), 2012, p6929-46
Wetterling, F., Gallagher, L., Macrae, I. M., Junge, S. and Fagan, A. J., Regional and temporal variations in tissue sodium concentration during the acute stroke phase, Magnetic Resonance in Medicine, 67, (3), 2012, p740 - 749
Wetterling et al., A dual resonator system for whole-body sodium-mri at 3T, 19th ANNUAL MEETING OF THE INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, Montreal, Canada, 2011, pp471
Heiler, Langhauser, Wetterling et al., Chemical shift sodium imaging in a mouse model of thromboembolic stroke at 9.4 T, JOURNAL OF MAGNETIC RESONANCE IMAGING, 34, 2011, p935 - 940
Wetterling, F., Gallagher, W. Holmes, L., Macrae, I. M., and Fagan, A. J., Temporal water mobility and sodium intensity measurements in penumbra and core tissue during acute stroke, International Society for Magnetic Resonance in Medicine, Montreal, Canada, 2011, pp470-
Wetterling et al., A double-tuned hydrogen-1/sodium-23 dual resonator system for tissue sodium concentration measurements in the rat brain via sodium mri, PHYSICS IN MEDICINE AND BIOLOGY, 55, 2010, p7681 - 7695
F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, The Quantification of Tissue Sodium Concentration using 23Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, pp5173-
F. Wetterling, M. Tabbert, S Junge, L. Gallagher, I.M. Macrae, A.J. Fagan, A double-tuned 1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI, Physics in Medicine and Biology, 55, 2010, p7681 - 7695
F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, A Double-Tuned 1H/23Na Two Element Phased Array System for In Vivo 23Na Magnetic Resonance Microscopy at 7 T, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, pp5272
F. Wetterling, L. Gallagher, I.M. Macrae, S. Junge, A.J. Fagan, Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T, Proceedings of 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, 15th Scientific Meeting of International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, May, 2010, pp5255-
Friedrich Wetterling, Judith Kisubi, Eva Haardt, Simon Konstandin, Armin Nagel, Marc Fatar, Eva Neumaier-Probst, Lothar R. Schad, Quantitative 23Na-MRI: From Pre-Clinical to Clinical Practice, 41st annual meeting of the German Association for Medical Physics (DGMP), Freiburg, Germany, 41, 2010, pp1
Friedrich Wetterling, The Detection of Infarcted Stroke Tissue via Localised Sodium Concentration Measurements: A Non-Invasive Approach, Trinity College Dublin, 2009
F. Wetterling, S. Junge, A. Nauerth, I.M. Macrae, .A.J. Fagan, The Measurement of Spatially-Dependant Tissue Sodium Concentration Increase in a Rodent MCAO Stroke Model, ISMRM 17th Scientific Meeting, Honolulu, USA, 18-24th April , 2009
Wetterling et al., The localization of focal heart activity via body surface potential measurements: tests in a heterogeneous torso phantom, PHYSICS IN MEDICINE AND BIOLOGY, 54, 2009, p5395 - 5409
Andrew Fagan, Friedrich Wetterling, Development of sodium-MRI for stroke and tumour investigations in rodents, IRISH JOURNAL OF MEDICAL SCIENCE, Faculty of Radiologists Royal College of Surgeons in Ireland, Dublin, 25-27 September 2008, edited by Irish Journal of Medical Science , 177, (Supplement 8), Springer, 2008, ppS271 - S271
F. Wetterling, O. Gobbo, M. Tabbert, S. Junge, A.J. Fagan., Sodium MRI using a two-element phased array coil: A quantification accuracy study, Annual Scientific Meeting, ESMRMB, Valencia, Spain, 2-4th Oct, 2008
Wetterling F., Gobbo O.L., Tabbert M., Junge S., Fagan A.J., A variable inductively coupled two-element phased array coil for rat brain Na-MRI at 7T., European Society for Magnetic Resonance in Medecine and Biology, 2008
Non-Peer-Reviewed Publications
Almudena Moreno-Borrallo, Friedrich Wetterling, Binh T. Mai, Eduardo Ruiz-Hernandez and Oliviero Gobbo, Preclinical evaluation of a pH-responsive nanocomposite in a refined GL261 Glioblastoma resection model, INOS meeting 2026, 2026
Maher, Marcos, Development of an Electromagnetic System for Magneto-Mechanical Stimulation of Nanoparticles in Tissue, Trinity College Dublin, 2026
Ritajaa Manna, Friedrich Wetterling, Maria Jose Santos-Martinez, and Oliviero L. Gobbo, A NEW MAGNETO-MECHANICAL APPARATUS FOR THE TREATMENT OF GLIOBLASTOMA, INOS meeting 2026, 2026
Almudena Moreno-Borrallo, Binh T. Mai, Eduardo Ruiz-Hernandez, Friedrich Wetterling, Oliviero Gobbo, Preclinical evaluation of a pH-responsive nanocomposite in a refined GL261 Glioblastoma resection model, European Association of Neuro-Oncology (EANO) 2026, 2026
Maria Anna Metaxaki, Design and development of single- and multi-element radiofrequency sensors at 105.9MHz for Sodium Magnetic Resonance Spectroscopy at 9.4 Tesla using low noise and low input impedance preamplifiers, Department of Electronic and Electrical Engineering Trinity College Dublin, 2025
Xinyu Zhang, Earth"s Field Magnetic Resonance Imaging in Urban Environments Noise Suppression and Advanced Image Reconstruction Techniques, Trinity College Dublin, 2025
Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless resonant circuit and variable inductance vascular monitoring implants and anchoring structures therefore', USPTO, 2023, 26 March 2024, Foundry Innovation and Research 1 Ltd
Hanson S Gifford III, Conor M Hanley, Jessi Johnson, Pablo Martin, Shriram Raghunathan, Stephen Sheridan, Douglas S Sutton, Fiachra M Sweeney, Friedrich Wetterling, 'Wireless vascular monitoring implants', USPTO, 10806352, 2020, 24 March 2024, Foundry Innovation & Research1, Ltd.,Dublin(IE)
Research Expertise
Projects
- Title
- Development of a nuclear magnetic resonance imaging technique for the accurate detection and quantification of tissue sodium concentration in animal models of disease.
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/05/2006
- Date To
- 27/09/2009
- Title
- A non-invasive deep brain stimulation device
- Funding Agency
- Enterprise Ireland
- Date From
- 2013
- Date To
- 2014
- Title
- Unlocking the potential of ultrahigh field 23Na magnetic resonance to quantify tissue sodium content for probing viability of the heart: where physics, biology and medicine meet
- Funding Agency
- European Commission
- Date From
- 1 January 2018
- Date To
- 31 December 2019
- Title
- Smart and wireless optical sensors for intra-vascular monitoring of blood volume in congestive heart failure
- Funding Agency
- The Naughton Fellowship Committee
- Date From
- October 2024
- Date To
- September 2026
- Title
- Supply of a Benchtop Magnetic Resonance (MRI) Systems for Trinity College Dublin (TCD)
- Summary
- From Larmor"s Legacy to Cutting-Edge MRI " Expanding Research Access in Ireland In 1897, Irish physicist Joseph Larmor uncovered the link between magnetic field strength and resonance frequency " the principle that underpins every modern Magnetic Resonance Imaging (MRI) scanner. More than a century later, we"re proud to continue that legacy at Trinity College Dublin. Our Medical Circuits and Systems Laboratory (MediCAS-Lab) has just received two PureDevices 0.5 T table-top MRI scanners " compact yet powerful systems capable of imaging samples up to 10 mm in diameter. While Ireland already hosts large MRI scanners for clinical use, these table-top systems provide a far more accessible, research-focused platform. They enable rapid experimentation, reduce barriers to early-stage studies, and offer valuable training opportunities for students and researchers exploring the next generation of imaging methods. This initiative was made possible through funding from the Higher Education Authority (Stream 1 " HEREG) and Trinity"s commitment to research excellence through the Trinity Research Charter. Small in size but big in impact, these systems will help us pioneer new MRI methods, train the next generation of imaging researchers, and expand Ireland"s research capacity in magnetic resonance. A heartfelt thank you to the Higher Education Authority, the Trinity Research Development Office, and all colleagues who made this possible. #TrinityCollegeDublin #MediCASLab #MRI #ImagingScience #ResearchExcellence #HigherEducationAuthority #Engineering #Innovation #Collaboration #JosephLarmor #Accessibility
- Funding Agency
- Minister for Further and Higher Education, Research, Innovation and Science
- Date From
- January 2025
- Date To
- December 2025
- Title
- Ultraminiature battery-free bioelectronic circuits to sense neural activity and its accompanying hemodynamic response function: exploring the opportunities for transcatheter delivered intravascular deep-implantable sensor solutions.
- Summary
- Implantable devices in medicine are changing how we take care of our health. They can monitor our body signals and provide customized treatments. However, these devices are limited because they rely on large batteries that need surgery to be replaced. So, it is essential to find ways to power them without using batteries, making them even smaller and better. This thesis deals with this challenge by developing new ways to wirelessly power these deep-implanted devices. First, it explores how the energy travels between the transmitter outside the body and the implanted receiver so we can figure out the best way to power it. Then, it introduces unique techniques that use innovative algorithms to ensure we can power these devices efficiently and safely. For this, the thesis uses computer models and real-life cases to show how these new techniques work and how well they perform. These models are also used to compare this new technique to the standard methods. Then, it gives some practical advice on how to make it work in real life. In the end, this research helps develop battery-free medical devices that are efficient and can be adapted for different applications. It also ensures patient safety and gives guidelines on how to power the next generation of bioelectronics. Finally, it provides a perspective into the future of wireless powering technologies applied to implantable devices.
- Funding Agency
- Research Ireland (formerly Irish Research Council - IRC)
- Date From
- 1/March/2026
- Date To
- 29/February/2028
- Title
- LOTUS: A Technology Breakthrough to Enable At Home Cancer Care in Oncology Patients
- Summary
- Current methods of delivering cancer treatment place a significant amount of time and financial burden on patients and on healthcare systems. Patients can spend up to 20% of their living days in clinics receiving cancer treatment (1). Meanwhile, the increasing incidence of cancer, coupled with an increase in the number of treatments per patient, is leading to a growing infusion clinic capacity crisis (2). At-home delivery of anti-cancer medication is an opportunity to meet this challenge by providing an alternative method of increasing patient throughput without drastic capital investment requirements for healthcare systems. At-home care can also dramatically reduce healthcare costs and improve quality of life for patients. This DTIF project aims to deliver on this opportunity through the development of the LOTUS home infusion delivery platform. LOTUS is a smart infusion system that gives patients easy and safe venous access through subcutaneous ports, subsequent taking of blood samples to track treatment progress, delivery of chemotherapy, and active monitoring of clinically important vital signs protecting against adverse events. Designed and manufactured in Ireland, LOTUS will provide more tolerable treatments and faster treatment access for patients, more cost-effective treatments for payors, and become the platform that accelerates the trend of community and home-based cancer care.
- Funding Agency
- Enterprise Ireland
- Date From
- 1/August/2025
- Date To
- 31/July/2028
- Title
- Living with a hereditary risk of sudden cardiac death: From patients to cells and psychology " Collaborate2Thrive
- Summary
- Sudden cardiac death (SCD) in young people is a devastating event that often occurs without warning. Many of these deaths are caused by inherited heart conditions that affect the electrical signals controlling the heartbeat. When a young person dies suddenly, the impact on families and communities is profound. Surviving relatives may discover that they too carry a genetic risk, leaving them to navigate fear, uncertainty, and difficult decisions about their health and lifestyle. This project aims to understand what it means to live with an inherited risk of SCD"not only from a medical perspective, but also from social, psychological, and cultural viewpoints. It brings together experts in cardiology, psychology, sociology, engineering, and medical imaging to build a complete picture of the condition and its impact across the lifecourse. The research has four main strands. First, we will speak directly with people who live with inherited cardiac risk through our Charity Partner (CRY) and establish a Patient and Public Involvement (PPI) committee, as well as their families and healthcare professionals, to understand their experiences, challenges, and support needs. Second, we will study how people think about their risk and what helps"or prevents"them from taking part in recommended health behaviours, such as regular check"ups or lifestyle changes. Third, we will develop new tools using artificial intelligence and advanced Magnetic Resonance Imaging (MRI) scanning to improve early diagnosis and identify who is most at risk. Finally, we will create laboratory models of the heart condition to better understand how it develops at the cellular level. By combining these different approaches, the project will generate new knowledge that can improve patient care, reduce uncertainty, and support people in making informed decisions about their health. It will also help healthcare systems use resources more efficiently by improving early detection and reducing unnecessary interventions. The project contributes to local and global sustainability goals by promoting equitable access to healthcare, reducing long"term disease burden, and supporting culturally sensitive approaches that respect the needs of diverse communities. It also trains four PhD researchers across social sciences, psychology, engineering, and medicine, helping to build future capacity for interdisciplinary health research. Ultimately, this work aims to improve the wellbeing and quality of life of individuals and families living with inherited cardiac risk, while contributing to safer, more inclusive, and more sustainable healthcare for all.
- Funding Agency
- Trinity College Dublin
- Date From
- 1/Spetember/2026
- Date To
- 31/July/2030
- Title
- Networked Distributed Neural Interfaces for Interference-Based Brain Stimulation
- Summary
- Invasive Deep Brain Stimulation (DBS) has become an important way to treat neurological diseases within the greying European society making a tether-less improvement desireable. The BRAINET team is convinced to have identified such an alternative in spatio-temporal Interference Stimulation (stIs). stIS avoids implantation into the brain and uses instead pairs of electrodes to precisely target activating beating rhythms in the depth of the brain at the therapeutic region, without requiring deep seated electrodes. In order to unleash this stimulation power in all regions of the brain, BRAINET sets out to develop skull implantable stimulation hubs which build a communication network and 3D targeting by self-organization, providing semantic information transfer and synchronization, and thus enabling virtual, self-adjusting pairs for therapeutic stIS. These stimulation hubs will be powered by novel magneto-electrical transducer stacks, driven by slowly alternating magnetic fields from the outside and will perform adjustable frequency stimulation by novel nano-modified, compliant electrodes only touching the brain. Network formation will be enabled by multiphysics approaches and ionic in-body communication instantiated in dedicated microelectronic hardware. Preclinical in-vitro and in-vivo testing of devices and methods will allow the community to make important steps towards subsequent clinical implementation of our «Wireless Transcalvarial Brain Stimulators". BRAINET will allow us to prepare the next generation of researchers, arming them with the knowledge, skills, and visionary insights necessary to drive neuro-technology to replace the present DBS into uncharted, but reliably safer and more flexible territories. BRAINET is an engine for excellence, interdisciplinary convergence, and innovation. Its dual mandate is to establish a training network and thus to lay the groundwork for emerging leaders.
- Funding Agency
- European Commission
- Date From
- 1/July/2026
- Date To
- 30/June/2029
- Title
- AI-Powered Clinical Trial Monitoring Solution
- Summary
- This project addresses a key bottleneck in clinical trials: traditional on-site monitoring of trials is costly, inefficient, and difficult to scale. Travel and personnel costs for Clinical Research Associates (CRAs) can consume up to 40% of a trial"s budget. Monitoring visits are scheduled in advance rather than triggered by real-time risk, meaning protocol deviations, missing data, or delayed adverse event (AE) reports are often detected too late. Manual Source Data Verification (SDV) accounts for over 60% of CRA time, while human error, subjectivity, and compliance risks persist. As the number of patients and the data volume grow, the current human-based model becomes a bottleneck in global, decentralized trials. The project introduces an AI-driven monitoring platform designed to transform this process. The innovation lies in automating repetitive tasks and intelligently prioritizing risks. Using Natural Language Processing (NLP) and Machine Learning (ML), both structured trial data (e.g., eCRFs) and unstructured information (e.g., physician notes, PDFs) are analyzed. Algorithms detect anomalies, identify potential and impending AEs, and automatically compare source and reported data. Real-time risk scores guide site prioritization, and dashboards deliver instant alerts before issues escalate. The "human-in-the-loop" design ensures that CRAs retain final decision-making authority while benefiting from accelerated and more precise insights from high complexity data sources.
- Funding Agency
- Enterprise Ireland
- Date From
- 2/May/2026
- Date To
- 1/Nov/2026
- Title
- StomaVue: A non-invasive volume-sensing stoma output device for leak prevention, dehydration risk reduction and remote ostomy care
- Funding Agency
- Enterprise Ireland
- Date From
- 16/October/2026
- Date To
- 15/April/2027
Recognition
Awards and Honours
Best Paper Award at IEEE Engineering in Medicine and Biology Conference, Toronto
AI Ireland award for best use of robotic process automation and cognitive Artificial Intelligence (AI)
Intel Prize at DCU Hackathon for presenting a low cost MRI solution to assess beef quality (as part of the Bó Selecta team)
Enterprise Ireland Commercialization Feasibility Grant (15.000EUR): A non-invasive deep brain stimulation device
Poster Prize (Ultra High Field Symposium, Berlin), Multi-nuclear magnetic resonance imaging at ultra-high magnetic field strength: probing sodium-23, chlorine-35, potassium-39, and phosphorus-31 signals in tissue deprived of arterial blood supply
Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'In vivo Hydrogen-1, Sodium-23, Phosphorus-31, and Potassium-39 Magnetic Resonance Imaging after Middle Cerebral Artery Occlusion'
Summa Cum Laude Merit Award (International Society for Magnetic Resonance in Medicine), 'Temporally-resolved imaging of renal sodium-23 changes after furosemid injection'
Siemens Young Investigator Award (German Society for Medical Physics), 'Sodium Concentration as a Marker for Tissue Viability after Ischaemic Stroke'
Selected member (by research proposal) of the 4th excellence initiative for molecular and disease-related imaging; German Science Foundation (DFG), Aachen, Germany
Selected member (by research proposal) of the 4th excellence initiative "molecular and disease-related imaging" 2010 German research association (DFG), Aachen, Germany
AstraZeneca Award (British Chapter of the International Society for Magnetic Resonance Imaging) for 'outstanding, innovative research with potential utility in medicine or medical research'
Award for the best oral presentation from a young scientist (Association of Physical Scientists in Medicine), 'A Dual RF Resonator System for Sodium MRI'
Memberships
International Society for Magnetic Resonance in Medicine (ISMRM)
IEEE Engineering in Medicine and Biology Society
IEEE Sensors Council