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Spotlight On... Andrew Bowie
The innate immune system is activated as a protective mechanism when cells sense the presence of strangers such as bacteria and viruses, or of dangers such as tissue injury. This leads to inflammation, which must be controlled in order to prevent disease. One way cell activation causes inflammation is by the formation of inflammasomes inside cells. Andrew’s team have shown that a protein called SARM can regulate inflammation by fine-tuning the response of a cell after inflammasome activation.