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Dr. John Southern
Assistant Professor, Chemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

McDonnell, C.M. and Ghanim, M. and Mike Southern, J. and Kelly, V.P. and Connon, S.J., De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P, Bioorganic and Medicinal Chemistry Letters, 59, (128545), 2022 Journal Article, 2022 DOI

Fergus C, Al-Qasem M, Cotter M, McDonnell CM, Sorrentino E, Chevot F, Hokamp K, Senge MO, Southern JM, Connon SJ, Kelly VP, The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity., Nucleic acids research, 2021, p4877-4890 Journal Article, 2021 TARA - Full Text DOI

Introduction to Aromatic Chemistry in, editor(s)Chris Rostron, Jill Barber , Pharmaceutical Chemistry, Second Edition, Oxford University Press, 2021, pp208 - 243, [Mike Southern] Book Chapter, 2021

Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon and Vincent P. Kelly, The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi-bi mechanism, Chemical communications, 56, 2020, p3915 - 3918 Journal Article, 2020 DOI TARA - Full Text

S.J. Connon and J.M. Southern, 'Substituted Pyrimidine Derivatives useful in the Treatment of Autoimmune Diseases', Rouse, WO2016050804 (A1), 2020 Patent, 2020 URL

Mangan D., Mcnabola N., Clark E.H., Bermudez I., Wonnacott S., Southern J.M., Ethyl-for-methyl substitution enhances the subtype specificity of mecamylamine analogues, Organic and Biomolecular Chemistry, 17, (46), 2019, p9892 - 9905 Journal Article, 2019 DOI

Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP. , In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis, Nucleic Acid Research, 45, (4), 2017, p2029 - 2039 Journal Article, 2017 URL

David Mangan, Neasa McNabola, Emily H. Clark, Isabel Bermudez, Susan Wonnacott and J. Mike Southern, A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties, Organic and Biomolecular Chemistry, 14, 2016, p10787 - 10798 Journal Article, 2016 URL

Neasa McNabola, Cornelius J. O'Connor, Mark D. Roydhouse, Michael D. Wall, J. Mike Southern, A one-pot synthesis of 3-nitrothiophene and 3-nitro-2-substituted thiophenes, Tetrahedron, 71, (28), 2015, p4598 - 4603 Journal Article, 2015 URL

Michael Southern and David Mangan, 'Derivatives of mecamylamine', Tomkins, 2013 Patent, 2013 URL

Introduction to Aromatic Chemistry in, editor(s)Chris Rostron Jill Barber , Pharmaceutical Chemistry (Integrated Foundations of Pharmacy), Oxford University Press, 2013, [Mike Southern] Book Chapter, 2013

O'Connor, CJ, Roydhouse, MD, Przybyl, AM, Wall, MD, Southern, JM, Facile Synthesis of 3-Nitro-2-substituted Thiophenes, JOURNAL OF ORGANIC CHEMISTRY, 75, (8), 2010, p2534-2538 Journal Article, 2010 DOI

Southern, J. Mike; O'Neil, Ian A.; Kearns, Peter, A concise synthesis of highly functionalised 4-thiosugar derivatives, Synlett, 14, 2008, p2158 - 2160 Journal Article, 2008

Preparation and reactions of iminophosphoranes and their synthetic applications in the aza-Wittig reaction. in, editor(s)P.J. Murphy , Organophosphorus Reagents A Practical Approach in Chemistry, Oxford University Press, 2004, pp151 - [J.Mike Southern and Ian A. O'Neil] Book Chapter, 2004

Ian A. O'Neil, J. Mike Southern, J. Chris Woolley and Heather Hobbs, The Synthesis of b-N-Tosylaminohydroxylamines via the Ring Opening of N-Tosylaziridines and Their Use in Reverse-Cope Cyclisations, Tetrahedron Letters, 42, 2001, p8243- Journal Article, 2001

Ian A. O'Neil, Ed Cleator, J. Mike Southern and David J. Tapolczay, The Stereospecific Addition of Hydroxylamines to a,b-Unsaturated Sulfones, Nitriles and Nitro compounds, Tetrahedron Letters, 42, 2001, p8251- Journal Article, 2001

Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Polyhydroxylated Pyrrolidines Using a Reverse-Cope Cyclisation., Synlett, 2000, p1408- Journal Article, 2000

Ian. A. O'Neil, Ed Cleator, J. Mike Southern, Neal Hone, David J. Tapolczay, The Synthesis of Chiral Functionalised Piperidines Using a Reverse-Cope Cyclisation: The Effect of Solvent on Diastereoselectivity, Synlett, 2000, p695- Journal Article, 2000

Ian A. O'Neil, Andrew J. Potter, J. Mike Southern, Alexander Steiner and James V. Barkley, Conformationally Defined Piperazine bis(N-Oxides) Bearing Amino Acid Side Chains., Chemical Communications, 1998, p2511- Journal Article, 1998

Ian A. O'Neil and J. Mike Southern, The Synthesis of Functionalised b-Hydroxyhydroxylamines via the Ring Opening of Epoxides and Their Use in Reverse-Cope Cyclisations., Tetrahedron Letters, 39, 1998, p9089- Journal Article, 1998

Ian A. O'Neil and J. Mike Southern, A New Tin Mediated Pummerer Synthesis of Vinyl Stannanes., Synlett, 1997, p1165- Journal Article, 1997

I. E. Markó, J. M. Southern and H. Adams, Towards the Total Synthesis of Manzamines. Rapid and Efficient Assembly of a Middle Core Model, Tetrahedron Letters, 33, 1992, p4657- Journal Article, 1992

I. E. Markó, J. M. Southern and M. L. Kantam, Stoichiometric C-C Bond Formation Using Triorganothallium Reagents., Synlett, 1991, p235- Journal Article, 1991

I. E. Markó and J. M. Southern, Triorganothallium Reagents in Organic Chemistry. 1. A Simple, Efficient and Versatile Preparation of Ketones from Acid Chlorides, Journal of Organic Chemistry, 55, 1991, p3368- Journal Article, 1991

Non-Peer-Reviewed Publications

J.M. Southern, Commercialisation of research, 1st year medicinal chemistry external lecture series, DIT, 2019 Invited Talk, 2019

Recognition

Representations

Reviewer of Dublin City University's Periodic Programme Review - a review of the BSc in Chemical and Pharmacuetical Sciences. 2020

Awards and Honours

Visiting Professor, Louvain-la-Neuve University, Belgium Jan-Apr 2006

Memberships

Chartered Chemist and Member of the Royal Society of Chemistry