Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search

You are here People

Dr. Sinead Smith
Ussher Assistant Professor, Clinical Medicine
Ussher Assistant Professor, Pharmacy

Publications and Further Research Outputs

Peer-Reviewed Publications

Zhang X, Smith S, Wang X, Zhao B, Wu L, Hu X., Three paralogous clusters of miR-17~92 family microRNAs restrain IL-12-mediated immune defense, Cellular & Molecular Immunology, 18, (7), 2021, p1751 - 1760 Journal Article, 2021 DOI

Purification of Total RNA from Stomach Tissue Biopsies. in, Methods Mol Biol. 2283, 2021, pp51 - 59, [FitzGerald R, Devapal M, Hickey JJ, McNamara D, Kelleher D, Smith SM.] Book Chapter, 2021 DOI

Megraud F, Bruyndonckx R, Coenen S, Wittkop L, Huang TD, Hoebeke M, Bénéjat L, Lehours P, Goossens H, Glupczynski Y; European Helicobacter pylori Antimicrobial Susceptibility Testing Working Group., Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community, Gut, Apr 9, (gutjnl-2021-324032), 2021 Journal Article, 2021 DOI

Zaslona Z, Flis E, Nulty C, Kearney J, Fitzgerald R, Douglas AR, McNamara D, Smith S, O'Neill LAJ, Creagh EM., Caspase-4: A Therapeutic Target for Peptic Ulcer Disease, Immunohorizons, 4, (10), 2021, p627 - 633 Journal Article, 2021 DOI

Alavifard H, Mirzaei N, Yadegar A, Baghaei K, Smith SM, Sadeghi A, Zali MR, Investigation of Clarithromycin Resistance-Associated Mutations and Virulence Genotypes of Helicobacter pylori Isolated from Iranian Population: A Cross-Sectional Study, Current Microbiology, 78, 2021, p244 - 254 Journal Article, 2021 DOI

Nyssen OP, Perez-Aisa A, Tepes B, Castro-Fernandez M, Kupcinskas J, Jonaitis L, Bujanda L, Lucendo A, Jurecic NB, Perez-Lasala J, Shvets O, Fadeenko G, Huguet JM, Kikec Z, Bordin D, Voynovan I, Leja M, Machado JC, Areia M, Fernandez-Salazar L, Rodrigo L, Alekseenko S, Barrio J, Ortuño J, Perona M, Vologzhanina L, Romero PM, Zaytsev O, Rokkas T, Georgopoulos S, Pellicano R, Buzas GM, Modolell I, Gomez Rodriguez BJ, Simsek I, Simsek C, Lafuente MR, Ilchishina T, Camarero JG, Dominguez-Cajal M, Ntouli V, Dekhnich NN, Phull P, Nuñez O, Lerang F, Venerito M, Heluwaert F, Tonkic A, Caldas M, Puig I, Megraud F, O'Morain C, Gisbert JP; Hp-EuReg Investigators., Adverse Event Profile During the Treatment of Helicobacter pylori: A Real-World Experience of 22,000 Patients From the European Registry on H. pylori Management (Hp-EuReg)., American Journal of Gastroenterology, 116, (6), 2021, p1220 - 1229 Journal Article, 2021 DOI

Molecular Detection of Antibiotic-Resistant Helicobacter pylori. in, Methods Mol Biol. 2283, 2021, pp29 - 36, [Brennan D, O'Morain C, McNamara D, Smith SM.] Book Chapter, 2021 DOI

Sinead Smith, Helicobacter pylori, Springer Nature , 2021 Book, 2021 URL DOI

Nyssen OP, Bordin D, Tepes B, Pérez-Aisa Á, Vaira D, Caldas M, Bujanda L, Castro-Fernandez M, Lerang F, Leja M, Rodrigo L, Rokkas T, Kupcinskas L, Pérez-Lasala J, Jonaitis L, Shvets O, Gasbarrini A, Simsek H, Axon ATR, Buzás G, Machado JC, Niv Y, Boyanova L, Goldis A, Lamy V, Tonkic A, Przytulski K, Beglinger C, Venerito M, Bytzer P, Capelle L, Milosavljević T, Milivojevic V, Veijola L, Molina-Infante J, Vologzhanina L, Fadeenko G, Ariño I, Fiorini G, Garre A, Garrido J, F Pérez C, Puig I, Heluwaert F, Megraud F, O'Morain C, Gisbert JP; Hp-EuReg Investigators, European Registry on Helicobacter pylori management (Hp-EuReg): patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21,533 patients, Gut, 70, (1), 2021, p40 - 54 Journal Article, 2021 DOI

Helicobacter pylori Virulence Factor Genotyping. in, Methods Mol Biol. 2283, 2021, pp93 - 106, [FitzGerald R, Sinha C, Yadegar A, Smith SM.] Book Chapter, 2021 DOI

Bujanda L, Nyssen OP, Vaira D, Saracino IM, Fiorini G, Lerang F, Georgopoulos S, Tepes B, Heluwaert F, Gasbarrini A, Rokkas T, Bordin D, Smith S, Lamy V, Caldas M, Resina E, Muñoz R, Cosme A, Puig I, Megraud F, O'Morain C, Gisbert JP and on behalf of the Hp-EuReg Investigators. , Antibiotic Resistance Prevalence and Trends in Patients Infected with Helicobacter pylori in the Period 2013-2020: Results of the European Registry on H. pylori Management (Hp-EuReg), Antibiotics, 10, (9), 2021, p1058- Journal Article, 2021 DOI

An Overview of Helicobacter pylori Infection. in, Methods Mol Biol. 2283, 2021, pp1 - 14, [FitzGerald R, Smith SM.] Book Chapter, 2021 DOI

Douglas AR, Holleran G, Smith SM, McNamara D., Shared changes in angiogenic factors across gastrointestinal vascular conditions: a pilot study., World Journal of Gastrointestinal Pharmacology & Therapeutics., 11, (3), 2020, p40 - 47 Journal Article, 2020

Kang L, Zhang X, Ji L, Kou T, Smith S, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X., The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens, Journal of Experimental Medicine, 217, (4), 2020, pe20190762 Journal Article, 2020 DOI

Farzi N, Yadegar A, Sadeghi A, Aghdaei HA, Smith SM, Raymond J, Suzuki H, MR Zali., High Prevalence of Antibiotic Resistance in Iranian Helicobacter pylori Isolates: Importance of Functional and Mutational Analysis of Resistance Genes and Virulence Genotyping, Journal of Clinical Medicine, 8, (11), 2019, pE2004- Journal Article, 2019 TARA - Full Text DOI

Smith SM, O'Morain C, McNamara D, Helicobacter pylori resistance to current therapies., Current Opinion in Gastroenterology, 35, (1), 2019, p6 - 13 Journal Article, 2019 DOI

Berthenet E, Yahara K, Thorell K, Pascoe B, Meric G, Mikhail JM, Engstrand L, Enroth H, Burette A, Megraud F, Varon C, Atherton JC, Smith S, Wilkinson TS, Hitchings MD, Falush D, Sheppard SK., A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk., BMC Biology, 16, (1), 2018, p84- Journal Article, 2018 DOI

Brennan D, Dowd C, O'Morain C, McNamara D*, Smith SM*, Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?, World Journal of Gastroenterology, 24, (9), 2018, p971 - 981 Journal Article, 2018 TARA - Full Text DOI

Smith S,Boyle B, Brennan D, Buckley M, Crotty P, Doyle M, Farrell R, Hussey M, Kevans D, Malfertheiner P, Megraud F, Nugent S, O'Connor A, O'Morain C, Weston S, McNamara D, The Irish Helicobacter pylori Working Group consensus for the diagnosis and treatment of H. pylori infection in adult patients in Ireland., European Journal of Gastroenterology & Hepatology, 27, (5), 2017, p552 - 559 Journal Article, 2017 DOI

Holleran G, Hussey M, Smith S, McNamara D., Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia., World Journal of Gastrointestinal Pathophysiology, 8, (3), 2017, p127 - 132 Journal Article, 2017 DOI

Tighe D, Hall B, Jeyarajah SK, Smith S, Breslin N, Ryan B, McNamara D., One-Year Clinical Outcomes in an IBD Cohort Who Have Previously Had Anti-TNFa Trough and Antibody Levels Assessed., Inflammatory Bowel Diseases, 23, (7), 2017, p1154 - 1159 Journal Article, 2017 DOI

Smith SM, Strategies for the purification of membrane proteins, Methods in Molecular Biology, 1485, 2017, p389 - 400 Journal Article, 2017 DOI TARA - Full Text

Smith SM, Freeley M, Moynagh P, Kelleher D, Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins., Helicobacter, 22, (1), 2017, pdoi: 10.1111/hel.12325 Journal Article, 2017 DOI TARA - Full Text

Tighe D, Smith S, O'Connor A, Breslin N, Ryan B, McNamara D , Positive relationship between infliximab and adalimumab trough levels at completion of induction therapy with clinical response rates, at a tertiary referral center, JGH Open, 1, (1), 2017, p4 - 10 Journal Article, 2017 DOI

Hussey M, Holleran G, Smith S, Sherlock M, McNamara D, The Role and Regulation of the 11 Beta-Hydroxysteroid Dehydrogenase Enzyme System in Patients with Inflammatory Bowel Disease., Digestive Diseases and Sciences, 62, (12), 2017, p3385 - 3390 Journal Article, 2017 DOI

O'Morain C, Smith S, Heliocbacter pylori treatment failure: the rationale for alternative antibiotics, Digestion, 93, (4), 2016, p309 - 310 Journal Article, 2016 TARA - Full Text DOI

Verma NK, Fazil MH, Ong ST, Chalasani ML, Low JH, Kottaiswamy A, P P, Kizhakeyil A, Kumar S, Panda AK, Freeley M, Smith SM, Boehm BO, Kelleher D., LFA-1/ICAM-1 Ligation in human T Cells promotes Th1 polarization through a GSK3β signaling-dependent Notch pathway. , Journal of Immunology, 197, (1), 2016, p108 - 118 Journal Article, 2016 DOI

Shang Y*, Smith S*, Hu X., Role of Notch signaling in regulating innate immunity and inflammation in health and disease, Protein & Cell, 7, (3), 2016, p159 - 174 Journal Article, 2016 TARA - Full Text DOI

Brennan DE, Omorogbe J, Hussey M, Tighe D, Holleran G, O'Morain C, Smith SM*, McNamara D*., Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples, World Journal of Gastroenterology, 7, (22), 2016, p9214 - 9221 Journal Article, 2016 DOI TARA - Full Text

Miller CH, Smith SM, Elguindy M, Zhang T, Xiang JZ, Hu X, Ivashkiv L, Zhao B., RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis, Journal of Immunology, 196, (12), 2016, p4977 - 4986 Journal Article, 2016 DOI

Non-invasive molecular tests for H. pylori in, Hospital Healthcare Europe 2016, London, Cogoro, 2016, pp197 - 199, [Brennan DE, McNamara D, Smith SM] Book Chapter, 2016 TARA - Full Text URL

Smith SM, An update on the treatment of Helicobacter pylori infection, EMJ Gastroenterology, 4, (1), 2015, p101 - 107 Journal Article, 2015 TARA - Full Text URL

Haider RB, Brennan DE, Omorogbe J, Holleran G, Hall B, O'Morain C, Breslin N, O'Connor HJ, Smith SM*, McNamara D*., A randomized-controlled study to compare the efficacy of sequential therapy with standard triple therapy for Helicobacter pylori eradication in an Irish population., European Journal of Gastroenterology & Hepatology, 27, (11), 2015, p1265 - 1269 Journal Article, 2015 DOI

Raftery T, Merrick M, Healy M, Mahmud N, O'Morain C, Smith S, McNamara D, O'Sullivan M., Vitamin D Status Is Associated with Intestinal Inflammation as Measured by Fecal Calprotectin in Crohn's Disease in Clinical Remission., Digestive Diseases and Sciences, 60, (8), 2015, p2427 - 2435 Journal Article, 2015 DOI

Holleran G, Hall B, O'Regan M, Smith S, McNamara D., Expression of Angiogenic Factors in Patients With Sporadic Small Bowel Angiodysplasia., Journal of Clinical Gastroenterology, 49, (10), 2015, p831 - 836 Journal Article, 2015 DOI

Smith SM, Haider RB, O'Connor H, McNamara D, O'Morain C., Practical treatment of Helicobacter pylori: a balanced view in changing times., European Journal of Gastroenterology & Hepatology, 26, (8), 2014, p819 - 825 Journal Article, 2014 DOI

microRNA Profiling: An Overview of Current Technologies and Applications in, editor(s)García-Cañas V, Cifuentes A, Simó C. , Applications of Advanced Omics Technologies: From Genes to Metabolites, Elsevier, 2014, pp23 - 46, [Smith SM, Murray DW] Book Chapter, 2014 TARA - Full Text

Hall B, Holleran G, Chin JL, Smith S, Ryan B, Mahmud N, McNamara D., A prospective 52 week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy., Journal of Crohn's & Colitis, S1873-9946, (14), 2014, p286-4- Journal Article, 2014 DOI

Smith SM, O'Morain C, McNamara D, Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance, World Journal of Gastroenterology, 20, (29), 2014, p9912 - 9921 Journal Article, 2014 DOI

Hall BJ, Holleran GE, Smith SM, Mahmud N, McNamara DA., A prospective 12-week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy., European Journal of Gastroenterology & Hepatology, 26, (11), 2014, p1253 - 1259 Journal Article, 2014 DOI

Smith, SM, Role of Toll-like receptors in Helicobacter pylori infection and immunity., World Journal of Gastrointestinal Pathophysiology, 5, (3), 2014, p133 - 146 Journal Article, 2014

Campion EM, Hakimjavadi R, Loughran ST, Phelan S, Smith SM, D'Souza BN, Tierney RJ, Bell AI, Cahill PA, Walls D, Repression of the pro-apoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonises TGF-β1-induced B-cell apoptosis, Journal of Virology, 88, (9), 2014, p5001 - 5013 Journal Article, 2014

An overview of microRNA methods: expression profiling and target identification in, editor(s)Virginia Espina & Lance Liotta , Methods in Molecular Biology, Springer, 2012, pp119 - 138, [Smith SM, Murray DW.] Book Chapter, 2012 URL

Xu H*, Zhu J*, Smith S*, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X., Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization., Nature Immunology, 13, (7), 2012, p642 - 650 Journal Article, 2012 TARA - Full Text URL

Smith SM, Moran AP, Duggan S, Ahmed SE, Mohamed AS, Windle HJ, O'Neill L, and Kelleher D., Tribbles 3: A Novel Regulator of TLR2-Mediated Signaling in Response to Helicobacter pylori Lipopolysaccharide , Journal of Immunology, 186, (4), 2011, p2462 - 2471 Journal Article, 2011 URL

Strategies for the purification of membrane proteins in, editor(s)Dermot Walls & Sinead Loughran , Methods in Molecular Biology, Springer, 2011, pp485 - 496, [Smith SM] Book Chapter, 2011 URL TARA - Full Text

Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, O'Brien J, Ní Eidhin D, O'Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O'Neill LA, Kelleher D, Loscher CE., A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins., PLOS: Pathogens, 7, (6), 2011, pe1002076- Journal Article, 2011 URL TARA - Full Text

Loughran ST, Campion EM, D'Souza BN, Smith SM, Vrzalikova K, Wen K, Murray PG, Walls D., Bfl-1 is a crucial pro-survival nuclear factor-κB target gene in Hodgkin/Reed-Sternberg cells., International Journal of Cancer, 129, (12), 2011, p2787 - 2796 Journal Article, 2011

Duggan SP, Behan FM, Kirca M, Smith S, Reynolds JV, Long A, Kelleher D, An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, down regulated in Barrett's oesophagus, which regulates NF-kB activation and cytokine levels., Carcinogenesis, 5, 2010, p936 - 945 Journal Article, 2010 DOI URL

Mullaney E, Brown PA, Smith SM, Botting CH, Yamaoka YY, Terres AM, Kelleher DP, Windle HJ, Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori, Proteomics Clinical Applications, 3, 2009, p785 - 796 Journal Article, 2009

Malizia AP, Keating DT, Smith SM, Walls D, Doran PP, Egan JJ., Alveolar Epithelial Cell Injury with Epstein Barr Virus Upregulates TGF{beta}1 Expression., American Journal of Physiology-Lung Cellular and Molecular Physiology, 295, (3), 2008, pL451 - L460 Journal Article, 2008 URL

Pegman PM, Smith SM, D'Souza BN, Loughran ST, Maier S, Kempkes B, Cahill PA, Simmons MJ, Gélinas C, Walls D., Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway., Journal of Virology, 80, (16), 2006, p8133 - 8144 Journal Article, 2006 URL

Keating DT, Sadlier DM, Patricelli A, Smith SM, Walls D, Egan JJ, Doran PP., Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells., Respiratory Research, 1, (7), 2006, p114 - 129 Journal Article, 2006 URL TARA - Full Text

D'Souza BN, Edelstein LC, Pegman PM, Smith SM, Loughran ST, Clarke A, Mehl A, Rowe M, Gélinas C, Walls D., Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor., Journal of Virology, 78, (4), 2004, p1800 - 1816 Journal Article, 2004 URL

Research Expertise


ANTIBIOTIC RESISTANCE; Bacteriology and bacterial pathogenesis; Biology; Biomedical sciences; Chronic inflamation; DNA transcription and translation; Gene transcription in human cancer; H Pylori and peptic ulcer; Host, Pathogen interactions; Immune system; Infectious diseases; Innate immunology; Molecular Biology; Molecular Genetics; Mucosal immunology; NOTCH; NUCLEAR FACTOR KAPPA B; Regulatory methods of gene expression; TOLL-LIKE RECEPTOR; Virology and viral pathogenesis



National Coordinator of the European Registry on Helicobacter pylori management (Hp-EuReg) 2020-present

Frontiers in Immunology Editorial Board Member 2020-present

National Coordinator of the European Helicobacter pylori Antimicrobial Susceptibility Testing Working Group 2018-present

Coordinator of the Irish Helicobacter pylori Working Group 2015-present

World Journal of Gastroenterology Editorial Board Member 2014-present