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Dr. Sharon O'Toole
Snr Experimental Officer, Obstetrics
Senior Research Fellow, Histopathology

Biography

Sharon O'Toole is a senior research fellow in Trinity College Dublin working in the area of ovarian cancer. She qualified with a BSc Hons in UCG in 1994 and then completed an MSc Biotechnology in 1996. Having worked in industry she then returned to research and completed a PhD in Trinity College in 2003. She has gained enormous experience in the area of ovarian cancer and has played a major role in the development of studies in gynaecological cancer. She was instrumental in establishing the DISCOVARY consortium which is a multidisciplinary and trans- institutional consortium dedicated to addressing the problems of ovarian and uterine cancer. The consortium manages the largest ovarian cancer bioresource in the country. The consortium has now merged to form INNOVATION- the Irish National Network for Ovarian Cancer Collaboration which has brought together the medical, research and charity organisations involved in ovarian cancer in Ireland. Her research interests centre around diagnostic and prognostic biomarkers and understanding the fundamental biology of the metastatic cascade and circulating tumour cells. She has been successful in identifying diagnostic and prognostic biomarkers for ovarian cancer and her ultimate aim is to translate these into the clinic. She has presented at both national and international conferences and published in peer-reviewed journals. She works closely with the 3 ovarian cancer charities in Ireland whose mission is to improve outcomes for ovarian cancer in Ireland. She was part of the organising committee of the first World Ovarian Cancer Day on May 8th in 2013 and this has now become an annual event.

Publications and Further Research Outputs

Peer-Reviewed Publications

Ffrench B, Kashdan E, Huang Y, Spillane CD, Cocchiglia S, Charmsaz S, Varešlija D, O'Brien C, Scholz D, Martin C, Gallagher M, Brooks DA, Brooks RD, Selemidis S, Gleeson N, AbuSaadeh F, O'Riain C, Kamran W, Flavin R, Young L, O'Toole SA, O'Leary JJ., CTC-5: A novel digital pathology approach to characterise circulating tumour cell biodiversity., Heliyon, 9, (1), 2023, pe13044 Journal Article, 2023 DOI

Bates M, Mohamed BM, Ward MP, Kelly TE, O'Connor R, Malone V, Brooks R, Brooks D, Selemidis S, Martin C, O'Toole S, O'Leary JJ., Circulating tumour cells: The Good, the Bad and the Ugly., Biochim Biophys Acta Rev Cancer, 1878, (2), 2023, p188863 Journal Article, 2023 TARA - Full Text DOI

Mohamed BM, Ward MP, Bates M, Spillane CD, Kelly T, Martin C, Gallagher M, Heffernan S, Norris L, Kennedy J, Saadeh FA, Gleeson N, Brooks DA, Brooks RD, Selemidis S, O'Toole S, O'Leary JJ., Ex vivo expansion of circulating tumour cells (CTCs)., Scientific reports, 13, (1), 2023, p3704 - 3704 Journal Article, 2023 DOI

Martini C, Logan JM, Sorvina A, Gordon C, Beck AR, S-Y Ung B, Caruso MC, Moore C, Hocking A, Johnson IRD, Li KL, Karageorgos L, Hopkins AM, Esterman AJ, Huzzell C, Brooks RD, Lazniewska J, Hickey SM, Bader C, Parkinson-Lawrence E, Weigert R, Sorich MJ, Tewari P, Martin C, O'Toole S, Bates M, Ward M, Mohammed B, Keegan H, Watson W, Prendergast S, Heffernan S, NiMhaolcatha S, O'Connor R, Malone V, Carter M, Ryan K, Brady N, Clarke A, Sokol F, Prabhakaran S, Stahl J, Klebe S, Samaratunga H, Delahunt B, Selemidis S, Moretti KL, Butler LM, O'Leary JJ, Brooks DA., Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer., Pathology, 2022, pS0031-3025(22)00226-4 Journal Article, 2022 DOI

Oseghale O, Liong S, Coward-Smith M, To EE, Erlich JR, Luong R, Liong F, Miles M, Norouzi S, Martin C, O'Toole S, Brooks RD, Bozinovski S, Vlahos R, O'Leary JJ, Brooks DA, Selemidis S., Influenza A virus elicits peri-vascular adipose tissue inflammation and vascular dysfunction of the aorta in pregnant mice., PLoS pathogens, 18, (8), 2022, pe1010703 Journal Article, 2022 DOI

Sharkey Ochoa I, O'Regan E, Toner M, Kay E, Faul P, O'Keane C, O'Connor R, Mullen D, Nur M, O'Murchu E, Barry-O'Crowley J, Kernan N, Tewari P, Keegan H, O'Toole S, Woods R, Kennedy S, Feeley K, Sharp L, Gheit T, Tommasino M, O'Leary JJ, Martin CM., The Role of HPV in Determining Treatment, Survival, and Prognosis of Head and Neck Squamous Cell Carcinoma., Cancers, 14, (17), 2022, p4321 Journal Article, 2022 DOI

Ward MP, O'Toole SA, Abu Saadeh F, Marchocki Z, Ibrahim EM, Martin F, Gleeon N, O'leary JJ, Norris LA, Mechanisms of cancer associated thrombosis in gynaecological cancer patients- tumour or treatment effect?, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, London, July 2022, 6, (Supplement 2), Wiley, 2022, ppPB0752 - PB0752 Conference Paper, 2022 URL

Spillane CD, Cooke NM, Ward MP, Kenny D, Blackshields G, Kelly T, Bates M, Huang Y, Martin C, Skehan S, Canney A, Gallagher M, Smyth P, Brady N, Clarke A, Mohamed B, Norris L, Brooks DA, Brooks RD, Heatlie JK, Selemidis S, Hanniffy S, Dixon E, Sheils O, O'Toole SA, O'Leary JJ., The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon., Translational oncology, 14, (12), 2021, p101229 Journal Article, 2021 DOI

Ward, M.P., Kane, L.E., Norris, L.A et al. , Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?, Molecular Cancer, 20, 2021, p59- Journal Article, 2021 DOI

Abu Saadeh F, Marchocki Z, O'Toole SA, Ibrahim N, Gleeson N, Norris LA., Extended thromboprophylaxis post gynaecological cancer surgery; the effect of weight adjusted and fixed dose LMWH (Tinzaparin)., Thrombosis Research, 207, 2021, p25 - 32 Journal Article, 2021 DOI

Tewari P, Banka P, Kernan N, Reynolds S, White C, Pilkington L, O'Toole S, Sharp L, D'Arcy T, Murphy C, Comiskey C, Martin CM, O'Leary JJ., Prevalence and concordance of oral HPV infections with cervical HPV infections in women referred to colposcopy with abnormal cytology., Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 50, (7), 2021, p692-699 Journal Article, 2021 DOI

Di Fiore R, Suleiman S, Ellul B, O'Toole SA, Savona-Ventura C, Felix A, Napolioni V, Conlon NT, Kahramanoglu I, Azzopardi MJ, Dalmas M, Calleja N, Brincat MR, Muscat-Baron Y, Sabol M, Dimitrievska V, Dimitrievska V, Yordanov A, Vasileva-Slaveva M, von Brockdorff K, Micallef RA, Kubelac P, Achima"-Cadariu P, Vlad C, Tzortzatou O, Poka R, Giordano A, Felice A, Reed N, Herrington CS, Faraggi D, Faraggi D, Calleja-Agius J., GYNOCARE Update: Modern Strategies to Improve Diagnosis and Treatment of Rare Gynecologic Tumors"Current Challenges and Future Directions , Cancers, 13, (3), 2021, p493 Journal Article, 2021 DOI

Kate McKendry Stephen Duff Yanmei Huang Mostafa Redha Áine Scanlon Feras Abu Saadeh Noreen Gleeson John O'Leary Lucy Norris Sharon O'Toole, The value of human epididymis 4, D‐dimer, and fibrinogen compared with CA 125 alone in triaging women presenting with pelvic masses: a retrospective cohort study, Acta Obstetricia et Gynecologica Scandinavica, 2021 Journal Article, 2021 URL

O'Sullivan L, Carroll TP, Clarke N, Cooper S, Cullen A, Gorman L, McCann B, Mee B, Miller N, Murphy V, Murray M, O'Leary J, O'Toole S, Snapes E, Bracken S., Harmonising the human biobanking consent process: an Irish experience. , HRB Open Res, 4, 2021, p96 Journal Article, 2021 DOI

Riccardo Di Fiore, Sherif Suleiman, Ana Felix, Sharon A O'Toole, John J O'Leary, Mark P Ward, James Beirne, Maja Sabol, Petar Ozretić, Angel Yordanov, Mariela Vasileva-Slaveva, Stoyan Kostov, Margarita Nikolova, Ian Said-Huntingford, Duncan Ayers, Bridget Ellul, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius, An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma, International Journal of Molecular Sciences, 22, 2021 Journal Article, 2021

Di Fiore R, Suleiman S, Pentimalli F, O'Toole SA, O'Leary JJ, Ward MP, Conlon NT, Sabol M, Ozreti" P, Erson-Bensan AE, Reed N, Giordano A, Herrington CS, Calleja-Agius J., Could MicroRNAs Be Useful Tools to Improve the Diagnosis and Treatment of Rare Gynecological Cancers? A Brief Overview., International journal of molecular sciences, 22, (8), 2021 Journal Article, 2021 DOI

Pisani D, Calleja-Agius J, Di Fiore R, O'Leary JJ, Beirne JP, O'Toole SA, Felix A, Said-Huntingford I., Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab., Current oncology (Toronto, Ont.), 28, (6), 2021, p5346-5355 Journal Article, 2021 DOI

O'Toole SA, Huang Y, Norris L, Power Foley M, Shireen R, McDonald S, Kamran W, Ibrahim N, Ward M, Thompson C, Murphy C, D'Arcy T, Farah N, Heron E, O'Leary JJ, Abu Saadeh F, Gleeson N., HE4 and CA125 as preoperative risk stratifiers for lymph node metastasis in endometrioid carcinoma of the endometrium: A retrospective study in a cohort with histological proof of lymph node status., Gynecologic oncology, 2021 Journal Article, 2021 DOI

Di Fiore R, Suleiman S, Drago-Ferrante R, Felix A, O'Toole SA, O'Leary JJ, Ward MP, Beirne J, Yordanov A, Vasileva-Slaveva M, Subbannayya Y, Pentimalli F, Giordano A, Calleja-Agius J., LncRNA MORT (ZNF667-AS1) in Cancer-Is There a Possible Role in Gynecological Malignancies?, International journal of molecular sciences, 22, (15), 2021 Journal Article, 2021 DOI

Kalachand RD, O'Riain C, Toomey S, Carr A, Timms KM, O'Toole S, Madden S, Bates M, O'Leary JJ, Gleeson N, O'Donnell D, Grogan L, Breathnach O, Farrelly A, Stordal B, Hennessy BT., Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer., Obstetrics & gynecology science, 63, (5), 2020, p643-654 Journal Article, 2020 DOI

Ali A, Zhang F, Maguire A, Byrne T, Weiner-Gorzel K, Bridgett S, O'Toole S, O'Leary J, Beggan C, Fitzpatrick P, McCann A, Furlong F., HDAC6 Degradation Inhibits the Growth of High-Grade Serous Ovarian Cancer Cells. , Cancers, 12, (12), 2020, pE3734 Journal Article, 2020 DOI

Liong S, Oseghale O, To EE, Brassington K, Erlich JR, Luong R, Liong F, Brooks R, Martin C, O'Toole S, Vinh A, O'Neill LAJ, Bozinovski S, Vlahos R, Papagianis PC, O'Leary JJ, Brooks DA, Selemidis S., Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice., Proceedings of the National Academy of Sciences of the United States of America, 2020 Journal Article, 2020 DOI TARA - Full Text

Norris LA, Ward MP, O'Toole SA, Marchocki Z, Ibrahim N, Khashan AS, Abu Saadeh F, Gleeson N., A risk score for prediction of venous thromboembolism in gynecologic cancer: The Thrombogyn score., Res Pract Thromb Haemost, 4, (5), 2020, p848-859 Journal Article, 2020 DOI

White, Christine M., Bakhiet, Salih, Bates, Mark, Ruttle, Carmel, Pilkington, Loretto J., Keegan, Helen, O"Toole, Sharon A., Sharp, Linda, O"Kelly, Ruth, Tewari, Prerna, Flannelly, Grainne, Martin, Cara M., O"Leary, John J., Exposure to tobacco smoke measured by urinary nicotine metabolites increases risk of p16/Ki-67 co-expression and high-grade cervical neoplasia in HPV positive women: A two year prospective study, Cancer Epidemiology, 68, 2020, p101793 Journal Article, 2020 DOI

O'Toole SA, Spillane C, Huang Y, Fitzgerald MC, Ffrench B, Mohamed B, Ward M, Gallagher M, Kelly T, O'Brien C, Ruttle C, Bogdanska A, Martin C, Mullen D, Connolly E, McGarrigle SA, Kennedy J, O'Leary JJ., Circulating tumour cell enumeration does not correlate with Miller-Payne grade in a cohort of breast cancer patients undergoing neoadjuvant chemotherapy., Breast cancer research and treatment, 181, (3), 2020, p571-580 Journal Article, 2020 DOI

Bates M, Spillane CD, Gallagher MF, McCann A, Martin C, Blackshields G, Keegan H, Gubbins L, Brooks R, Brooks D, Selemidis S, O'Toole S, O'Leary JJ., The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer., PloS one, 15, (12), 2020, pe0243715 Journal Article, 2020 DOI

Bates Mar, Furlong Fion, Gallagher Michael F, Spillane Cathy D, McCann Amand, O'Toole Sharo, O'Leary John J, Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer, 469, 2020, p11 - 21 Journal Article, 2020 URL DOI

Kalachand RD, Stordal B, Madden S, Chandler B, Cunningham J, Goode EL, Ruscito I, Braicu EI, Sehouli J, Ignatov A, Yu H, Katsaros D, Mills GB, Lu KH, Carey MS, Timms KM, Kupryjanczyk J, Rzepecka IK, Podgorska A, McAlpine JN, Swisher EM, Bernards SS, O'Riain C, O'Toole S, O'Leary JJ, Bowtell DD, Thomas DM, Prieske K, Joosse SA, Woelber L, Chaudhry P, Häfner N, Runnebaum IB, Hennessy BT., BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis., Journal of the National Cancer Institute, 2020 Journal Article, 2020 DOI

Jose, B. and Vijayaraghavan, R.K. and Kent, L. and O'Toole, S. and O'Leary, J. and Forster, R.J., Tunable metallic nanostructures using 3D printed nanosphere templates, Electrochemistry Communications, 98, 2019, p106-109 Journal Article, 2019 DOI

Annett Stephani, Moore Gillia, Short Am, Marshall Andre, McCrudden Cia, Yakkundi Anit, Das Sudipt, McCluggage W Glen, Nelson Laur, Harley Ia, Moustafa Nermee, Kennedy Catherine , deFazio Ann, Brand Aliso, Sharma Raghw, Brennan Dona, O†Toole Sharo, O†Leary Joh, Bates Mar, O†Riain Ciará, O†Connor Darra, Furlong Fion, McCarthy Hele, Kissenpfennig Adrie, McClements Lan, Robson Trac, FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer, 2019 Journal Article, 2019 URL DOI

Marchocki Z, Norris L, O'Toole S, Gleeson N, Abu Saadeh F, Patients' experience and compliance with extended low molecular weight heparin prophylaxis post-surgery for gynaecological cancer. A prospective observational study, International Journal of Gynaecological Cancer. , 2019 Journal Article, 2019 DOI

Cluxton, C.D. and Spillane, C. and O†Toole, S.A. and Sheils, O. and Gardiner, C.M. and O†Leary, J.J., Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade, PLoS ONE, 14, (3), 2019 Journal Article, 2019 TARA - Full Text DOI

Ward MP, Abu Saadeh, F, O'Toole S, Marchocki Z, Gleeson N, Norris LA, Optimisation of Thrombin Generation as a Predictive Biomarker for Venous Thromboembolism in Gynaecological Malignancies, Research Practice in Thrombosis and Haemostasis, International Society for Thrombosis and Haemostasis, Dublin, July 2018, 2, (Supplement 1), Wiley, 2018, ppPB518 - PB518 Published Abstract, 2018 DOI

Thompson C, Kamran W, Dockrell L, Khalid S, Kumari M, Ibrahim N, OʼLeary J, Norris L, Petzold M, OʼToole S, Gleeson N, The Clearance of Serum Human Epididymis Protein 4 Following Primary Cytoreductive Surgery for Ovarian Carcinoma, International Journal of Gynaecological Cancer, 28, (6), 2018, p1066 - 1072 Journal Article, 2018 DOI

B Jose, S O'Toole, R Forster, JJ O'Leary. , Smart Nanomotors: Towards in-vivo Sensing., Laboratory Investigation , USCAP, 97, ((S1)), 2017, pp530A- Published Abstract, 2017

Arts, Florence A and Keogh, Lisa and Smyth, Paul and O'Toole, Sharon and Ta, Robert and Gleeson, Noreen and O'Leary, John J and Flavin, Richard and Sheils, Orla, miR-223 potentially targets SWI/SNF complex protein SMARCD1 in atypical proliferative serous tumor and high-grade ovarian serous carcinoma, Human pathology, 70, 2017, p98 - 104 Journal Article, 2017 DOI

Sulaiman, G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blacksheilds G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee M, Campbell EL, Moynagh P, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ and Gallagher MF. , MyD88 is an essential component of retinoic acid induced differentiation in human pluripotent embryonal carcinoma cells. , Cell Death & Differentiation , 24, (11), 2017, p1975 - 1986 Journal Article, 2017

Ffrench B, Gasch, Hokamp K, Spillane C, Blackshields G, Mahgoub TM, Bates M, Kehoe L, Mooney A, Doyle R, Doyle B, O'Donnell D, Gleeson N, Hennessy BT, Stordal B, O'Riain C, Lambkin H, O'Toole S, O'Leary JJ, and Gallagher MF., CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell network. Cell Death & Disease , Cell Death and Disease, 8, (10), 2017, e3128 Journal Article, 2017 TARA - Full Text

Petch S, Norris L, O'Toole S, Gleeson N, Abu Saadeh F. , Peri operative venous thromboembolism prophylaxis in gynaecological cancer patients. A survey of current practice., Thrombosis Research, 145, 2016, p126 - 128 Journal Article, 2016 DOI

White C, Bakhiet S, Bates M, Keegan H, Pilkington L, Ruttle C, Sharp L, O' Toole S, Fitzpatrick M, Flannelly G, O' Leary JJ, Martin CM. , Triage of LSIL/ASC-US with p16/Ki-67 dual staining and human papillomavirus testing: a 2-year prospective study. , Cytopathology, 27, (4), 2016, p269 - 276 Journal Article, 2016 DOI

Abu Saadeh, F, Langhe R, Galvin DM, O Toole SA, O'Donnell DM, Gleeson N, Norris LA, Procoagulant activity in gynaecological cancer patients; the effect of surgery and chemotherapy. , Thrombosis Research, 139, 2016, p135 - 141 Journal Article, 2016 DOI

McEvoy LM, O'Toole SA, Spillane CD, Martin CM, Gallagher MF, Stordal B, Blackshields G, Sheils O, O'Leary JJ, Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer., BMC cancer, 15, 2015, p547 Journal Article, 2015

Martin CM, Astbury K, Kehoe L, O'Crowley JB, O'Toole S, O'Leary JJ. , The Use of MYBL2 as a Novel Candidate Biomarker of Cervical Cancer. , Methods Mol Biol, 1249, 2015, p241 - 251 Journal Article, 2015

Busschots S, O'Toole S, O'Leary JJ, Stordal B, Non-invasive and non-destructive measurements of confluence in cultured adherent cell lines., MethodsX, 2, 2015, p8-13 Journal Article, 2015

Langhe R, Norris L, Saadeh FA, Blackshields G, Varley R, Harrison A, Gleeson N, Spillane C, Martin C, O'Donnell DM, D'Arcy T, O'Leary J, O'Toole S, A novel serum microRNA panel to discriminate benign from malignant ovarian disease, Cancer Letters, 356, ((2ptB)), 2015, p628-636- Journal Article, 2015 DOI

d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816- Journal Article, 2014 DOI TARA - Full Text

Abu Saadeh F, O'Toole S, Gleeson N, Norris L, Peak ant-Xa levels following LMWH (tinzaparin) prophylaxis in gynaecological cancer patients post surgery, Thrombosis Research, 7th Internation Conference on Thrombosis & Hemostatis Issues in Cancer, , Bergamot Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014 Published Abstract, 2014

Keegan Helen, Pilkington Loretto, McInerney Jamie, Jeney Csaba, Benczik Márta, Cleary Sinead, von Bunau Gunther, Turner Michael, D'Arcy Tom, O' Toole Sharon, Borbála Pal-Szenthe, Borbála Kaltenecker, Johanna Mózes, Anettc Kovács, Agnes Solt, Bolger Noel, O'Leary John, Martin Cara., Human papillomavirus detection and genotyping, by HC2, Full-Spectrum HPV and Molecular Beacon Real-Time HPV assay in an Irish colposcopy clinic, Journal of Virological Methods, 2014 Journal Article, 2014 TARA - Full Text

Busschots S, O'Toole S, O'Leary JJ, Stordal B. , Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells, Experimental Cell Research, 2014, p1 - 14 Journal Article, 2014 TARA - Full Text DOI

Noninvasive Biomarkers in Ovarian Cancer in, editor(s)Debmalya Barh, Angelo Carpi, Mukesh Verma, Mehmet Gunduz , Cancer Biomarkers: Minimal and Noninvasive Early Diagnosis and Prognosis , CRC press, 2014, [O'Toole, SA, Ancuta, E, Langhe, R, Cahill, DJ, Murphy, M, Martin, C, McEvoy, L, Spillane, C, Sheils, O, Petricoin, E, Liotta, L, O'Leary JJ] Book Chapter, 2014

Abu Saadeh F, Norris L, O'Toole S, Gleeson N, Venous thromboembolism in ovarian cancer: Incidence, risk factors and impact on survival., European Journal of Obstetrics & Gynecology and Reproductive Biology , 170, (1), 2013, p214 - 218 Journal Article, 2013 Other

Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103 Journal Article, 2013 DOI TARA - Full Text

White C, Keegan H, Pilkington L, Ruttle C, Kerr P, Sharp L, O'Toole S, Turner M, Prendiville W, D'Arcy T, Fitzpatrick M, Lenehan P, Flannelly G, O'Leary JJ, Martin CM, Evaluation of the clinical performance of the cobas 4800 HPV test in patients referred for colposcopy., Journal of clinical microbiology, 51, (10), 2013, p3415-7 Journal Article, 2013 TARA - Full Text DOI

Abu Saadeh, Norris L, O'Toole S, Mohamed BM, Langhe R, O'Leary J, Gleeson N, Tumour expresion of tissue factor and tissue factor pathway inhibitor in ovarian cancer- relationship with venous thrombosis risk., Thrombosis Research, 132, 2013, p627 - 634 Journal Article, 2013 DOI

Abu Saadeh. F, Norris. L, O' Toole. S, Langhe. R, Gleeson. N., ETP as a marker for venous thromboembolism in gynaecologial cancer patients post surgery, International Journal of Gynecological Cancer, 14th Biennial Meeting of the International Gynecological Cancer Society., Vancouver, Canada, October 2012, 22, (Suppl 3), 2012, ppE249- Published Abstract, 2012

Abu Saadeh F, Norris L, O'Toole S, Langhe R, Gleeson N., Procoagulant activity in patients with gynecological malignancies and the effect of neoadjuvant chemotherapy , Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, (Suppl 1), Elsevier, 2012 Published Abstract, 2012 URL

Gallagher MF, Heffron CC, Laios A, O'Toole SA, Ffrench B, Smyth PC, Flavin RJ, Elbaruni SA, Spillane CD, Martin CM, Shelis OM, O'Leary JJ. , Suppression of Cancer Stemness p21-regulating mRNA and microRNA Signatures in Recurrent Ovarian Cancer Patient Samples. , Journal of Ovarian Research, 5, (1), 2012, p2- Journal Article, 2012 DOI

Abu Saadeh F, Norris L, O'Toole S, Langhe R, O'Leary JJ, Gleeson N., Does tissue factor and tissue factor pathway inhibitor over-expression play a role in the development of venous thromboembolism in ovarian cancer patients?, Thrombosis Research, 6th International Conference on Thrombosis & Hemostasis Issues in Cancer, Bergamo Italy, April 2012, edited by A Falanga, B. Brenner, F, Rickles , 129, ((Suppl 1)), Elsevier, 2012, pp170- Published Abstract, 2012 URL

Murphy MA, O'Connell DJ, O'Kane SL, O'Brien JK, O'Toole S, Martin C, Sheils O, O'Leary JJ, Cahill DJ, Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays, Journal of Proteomics, 75, (15), 2012, p4668 - 4675 Journal Article, 2012 TARA - Full Text

Furlong F, Fitzpatrick P, O'Toole S, Phelan S, McGrogan B, Maguire A, O'Grady A, Gallagher M, Prencipe M, McGoldrick A, McGettigan P, Brennan D, Sheils O, Martin C, W Kay E, O'Leary J, McCann A, Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer., The Journal of pathology, 226, (5), 2012, p746-55 Journal Article, 2012

Abu Saadeh. F, Norris. L, O' Toole, Gleeson. N., Assessing the risk and mortality of venous thromboembolism in ovarian cancer., International Journal of Gynecological Cancer, 14th Biennial Meeting of the International Gynecological Cancer Society., Vancouver, Canada, October 2012, 22, (Suppl 3), 2012, ppE246- Meeting Abstract, 2012

Abu Saadeh. F, Norris. L, O' Toole. S, Langhe. R, O' Leary. J, Gleeson. N. , Why is venous thromboembolism is a common complication of ovarian cancer? , International Journal of Gynecological Cancer , 14th Biennial Meeting of the International Gynecological Cancer Society. , Vancouver, Canada, October 2012, 22, (Suppl 3), 2012, ppE247- Published Abstract, 2012

Abu Saadeh. F, Norris. L, O' Toole. S, Langhe. R, Gleeson. N, Endogenous thrombin potential as a marker for venous thrombosis in ovarian cancer., International Journal of Gynecological Cancer , 14th Biennial Meeting of the International Gynecological Cancer Society., Vancouver, Canada, October 2012, 22, (Suppl 3), 2012, ppE248- Published Abstract, 2012

Egan K, Crowley D, Smyth P, O'Toole S, Spillane C, Martin C, Gallagher M, Canney A, Norris L, Conlon N, McEvoy L, Ffrench B, Stordal B, Keegan H, Finn S, McEneaney V, Laios A, Ducrée J, Dunne E, Smith L, Berndt M, Sheils O, Kenny D, O'Leary J, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLoS ONE, 6, (10, e26125), 2011 Journal Article, 2011 TARA - Full Text

Pilkington L, Keegan H, O'Toole S, Singh S, Cleary S, Prendiville W, Darcy T, Turner MJ,, Von Bunau G, Anglim M, O'Leary JJ, Martin CM. , The utility of HPV testing in predicting disease recurrence post colposcopic treatment for cervical intraepithelial neoplasia. , Modern Pathology/Laboratory Investigations, United Stated and Canadian Academy of Pathology, San Antonio, Texas, February 26-March 4, 91, (Supplement 1S), 2011, pp263A- Meeting Abstract, 2011

Ovarian Cancer Chemoresistance in, editor(s)Dr. rer. nat. Manfred Schwab , Encyclopedia of Cancer, SpringerReference, 2010, [O'Toole SA, O'Leary JJ] Book Chapter, 2010 URL

Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy in, Methods Mol Biol, 2009, pp333 - 359, [Martin CM, Astbury K, McEvoy L, O'Toole S, Sheils O, O'Leary JJ] Book Chapter, 2009 DOI

Flavin, R.J., Smyth, P.C., Laios, A., O'Toole, S.A., Barrett, C., Finn, S.P., Russell, S., (...), O'Leary, J.J. , Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma, Modern Pathology , 22, (2), 2009, p197-205 Journal Article, 2009 DOI

Gallagher MF, Flavin RJ, Elbaruni SA, McInerney JK, Smyth PC, Salley YM, Vencken SF, O'Toole SA, Laios A, Lee MY, Denning K, Li J, Aherne ST, Lao KQ, Martin CM, Sheils OM, O'Leary JJ, Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients., Journal of ovarian research, 2, 2009, p19 Journal Article, 2009 TARA - Full Text DOI

Flavin RJ, Smyth PC, Finn SP, Laios A, O'Toole SA, Barrett C, Ring M, Denning KM, Li J, Aherne ST, Aziz NA, Alhadi A, Sheppard BL, Loda M, Martin C, Sheils OM, O'Leary JJ., Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients., Modern Pathology, 21, (6), 2008, p676 - 684 Journal Article, 2008 URL

Laios, A., O'Toole, S.A., Flavin, R., Martin, C., Ring, M., Gleeson, N., D'Arcy, T., (...), O' Leary, J.J. , An integrative model for recurrence in ovarian cancer , Molecular Cancer, 7, 2008 Journal Article, 2008 DOI

Laios, A., O'Toole, S., Flavin, R., Martin, C., Kelly, L., Ring, M., Finn, S.P., (...), O'Leary, J. , Potential role of miR-9 and miR-223 in recurrent ovarian cancer , Molecular Cancer, 7, 2008, part. no. 35 Journal Article, 2008 TARA - Full Text DOI

O'Toole SA, Sheppard BL, Laios A, O'Leary JJ, McGuinness EP, D'Arcy T, Bonnar J., Potential predictors of chemotherapy response in ovarian cancer--how do we define chemosensitivity?, Gynecological Oncology, 104, (2), 2007, p345 - 351 Journal Article, 2007 URL

O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ., Genome wide analysis of DNA in endometrial cancer using comparative genomic hybridisation microarrays. , International Journal of Gynaecological Cancer , 16, (2), 2006, p834 - 842 Journal Article, 2006 URL

Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O and O'Leary JJ. , Molecular profiling of primary versus recurrent ovarian serous papillary adenocarcinomas. , Laboratory Investigation, United States and Canadian Society of Pathology, Atlanta, USA, Feb 2006, 86, (Suppl 1), Nature, 2006, pp185 - 185 Meeting Abstract, 2006

SA O'Toole, A Laios, BL Sheppard, NC Gleeson, T D'Arcy, EPJ McGuinness, J Bonnar, O Sheils and JJ O'Leary. , Potential predictors of chemotherapy response in ovarian cancer how do we define chemosensitivity?, Laboratory Investigation, United States and Canadian Society of Pathology, Atlanta, USA, Feb 2006, 86, (Suppl 1), Nature, 2006, pp190A Meeting Abstract, 2006

O'Toole SA, Dunn E, Sheppard BL, Sheils O, O'Leary JJ, Wuttke W, Seidlova-Wuttke, D, Oestrogen regulated gene expression in normal and malignant endometrial tissue. , Maturitas, 51, (2), 2005, p187 - 198 Journal Article, 2005 URL

O'Toole SA, Sheppard BL, Sheils O, O'Leary JJ, Spengler B, Christoffel V. , Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays., Planta Medica, 71, (5), 2005, p435 - 439 Journal Article, 2005 URL

(ed.), Predicting the response of gynaecological tumours to chemotherapy. , 24, (2A), 2004, 533 - 534 p Proceedings of a Conference, 2004

O'Toole SA, Sheppard BL, McGuinness EP, Gleeson NC, Yoneda M, Bonnar J, The MTS assay as an indicator of chemosensitivity/resistance in malignant gynaecological tumours. , Cancer Detection and Prevention , 27, (1), 2003, p47 - 54 Journal Article, 2003 URL

O'Toole SA, Sheppard BL, McGuinness E, Gleeson NC, Bonnar J., Serous papillary adenocarcinomas of the ovary display heterogeneity in their response to chemotherapy., International Journal of Gynaecological Cancer, 11, (5), 2001, p365 - 371 Journal Article, 2001 URL

O'Toole S, McGuinness E, Sheppard B, Bonnar J., Plasminogen activators and inhibitors in ovarian adenocarcinomas., International Journal of Gynaecological Cancer , 9, 1999, p61 - 66 Journal Article, 1999 URL

Non-Peer-Reviewed Publications

O'Leary JJ, White C, Spillane C, Naik, P, O'Brien, R, Reynolds, S, Pham, T, Pilkington, L, Sharkey Ochoa, I, Bolger, N, Barry O'Crowley, J, Tewari, P, O'Toole, S, Sweeney, M, Keegan, H, Normand, C, Sharp, L, Flannelly, G, Martin, CM. , Cervical screening: A new way forward (tests of risk and tests of disease) [version 1; referees: 1 approved, 1 approved with reservations]., HRB Open Research, 1, (3), 2018 Journal Article, 2018 DOI

Ibrahim N, Norris L, O'Toole S, McHugh T, Gleeson N, Does extended thromboprophylaxis help reduce the incidence of venous thromboembolism in gynaecological cancer patients?, Thrombosis Research, 7th Internation Conference onal Thrombosis & Hemostatis Issues in Cancer,, Bergamo Italy, May 2014, edited by A Falanga, B. Brenner, F, Rickles , 133, (Suppl 2), Elsevier, 2014 Published Abstract, 2014

Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, O'Leary JJ. (ed.), Irish Association for Cancer Research, Galway, Ireland, March 2006, 2006 Proceedings of a Conference, 2006

CM Martin, K Astbury, R Henfrey, O Sheils, M Gallagher, C Heffron, C Logan, SA O'Toole, JJ O'Leary, miRNA expression signatures in cervical cancer, Journal of RNAi and Gene Silencing, RNAi2006: Advances in RNA Interference Research, St Anne's College, Oxford, United Kingdom, March 2006, 2, (2), 2006 Meeting Abstract, 2006

Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, Smyth P, O'Leary JJ., Recurrent ovarian cancer cDNA signatures., Centenary Meeting of the Pathological Society of Great Britain and Ireland , Manchester, July 2006, 2006 Meeting Abstract, 2006

A Laios, SA O'Toole, B Sheppard, N Gleeson, T D'Arcy, E PJ McGuinness, M Ring, O Sheils and JJ O'Leary. , Transcriptome profiling of primary and recurrent ovarian cancers, Junior Obstetrics and Gynaecology Society, Dublin, Nov 2005, 2005 Meeting Abstract, 2005

O'Toole S, Laios A, Sheppard B, Smyth P, O'Regan E, Sheils O, O'Leary J. , Expression profiling of endometrial stromal cells treated with estradiol and phytoestrogens. , 20th European Congress of Pathology, Paris, Sept 2005, 2005 Meeting Abstract, 2005

O'Toole SA, Sheppard BL, D'Arcy T, Mc Guinness EPJ, Gleeson NC, Bonnar J, Sheils O, O'Leary JJ. , Angiogenesis in Ovarian Cancer does not predict response to chemotherapy., Irish Association for Cancer Research, Kilkenny, Ireland, March 2005, 2005 Meeting Abstract, 2005

O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ. , Angiogenesis markers in ovarian cancer act as prognostic markers but not indicators of chemotherapy response, Pathological Society of Great Britain and Ireland, Newcastle, UK, July 2005, 2005 Meeting Abstract, 2005

O'Toole SA, Sheppard BL, D'Arcy T, Mc Guinness EPJ, Gleeson NC, Bonnar J, Sheils O, O'Leary JJ. , Multidrug resistance gene only plays a role in some ovarian cancers, Irish Association for Cancer Research, Kilkenny, Ireland, March 2005, 2005 Meeting Abstract, 2005

O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ. , Potential Predictors of Chemotherapy Response in Ovarian Cancer., Irish gynaecological oncology society, Belfast, 2005, 2005 Meeting Abstract, 2005

SA O'Toole, E Dunn, BL Sheppard, P Smyth, C Martin, O Sheils, JJ O'Leary, J. Bektic, H. Klocker. , Genome wide analysis of DNA in endometrial cancer using comparative genomic hybridisation microarrays. , 5th International Symposium on Women's Health and Menopause, Florence, Italy, Apr 2004, 2004 Meeting Abstract, 2004

O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ. , Genome wide analysis of DNA in endometrial cancer using comparative genomic hybridisation microarrays, Irish gynaecological oncology society,, Cork, Ireland, 2004 Meeting Abstract, 2004

SA O'Toole, E Dunn, BL Sheppard, O Sheils, JJ O' Leary, W Wuttke, D. Seidlova-Wuttke. , Oestrogen regulated gene expression in normal and malignant endometrial tissue. , 5th International Symposium on Women's Health and Menopause, Florence, Italy, Apr 2004, 2004 Meeting Abstract, 2004

SA O'Toole, BL Sheppard, P Smyth, C Martin, O Sheils, JJ O'Leary, B Spengler, V Christoffel, Genome wide analysis of DNA in endometrial cells treated with phytoestrogens using comparative genomic hybridisation microarrays, 5th International Symposium on Women's Health and Menopause, Florence, Italy, Apr 2004, 2004 Meeting Abstract, 2004

SA O'Toole, E Dunn, BL Sheppard, O Sheils, JJ O' Leary, W Wuttke, D. Seidlova-Wuttke. , Oestrogen regulated gene expression in normal and malignant endometrial tissue. , Irish gynaecological oncology society, Cork, Ireland, 2004 Meeting Abstract, 2004

O'Toole SA, Sheppard BL, Sheils O, Smyth P, Martin C, O'Leary JJ, Spengler B, Christoffel V. , Genome wide analysis of DNA sequence copy number in endometrial cells treated with phytoserms using comparative genomic hybridisation microarrays. , Irish Association for Cancer Research, Kilkenny, Ireland, Apr 2003, 2003 Meeting Abstract, 2003

O'Toole SA, Sheppard BL, McGuinness EPJ, Gleeson NC, Yoneda M, Bonnar J., Determining the response of gynaecological tumours to chemotherapy using an MTS cytotoxicity assay in combination with an explant culture technique, British Journal of Cancer , 86, (Suppl 1), 2002, pS46 - S46 Journal Article, 2002

O'Toole S, Sheppard B.L., Bonnar J, McGuinness E, Gleeson N, Cell Culture drug sensitivity/resistance testing of malignant gynaecological tumours. , British Journal of Obstetrics and Gynaecology , 107, (6), 2000, p818 - 819 Journal Article, 2000

O'Toole S, Sheppard B, Bonnar J, McGuinness E. , Fibrinolysis in Ovarian Carcinomas. , Joint IACR/ISMO Cancer Research Meeting, Belfast, 1999, 1999 Meeting Abstract, 1999

O'Toole S, Sheppard BL, Bonnar J, McGuinness E, Gleeson N, Cell Culture drug sensitivity/resistance testing of malignant gynaecological tumours., Irish Journal of Medical Science, 168, (Suppl 3), 1999, pp35 - 35 Meeting Abstract, 1999

O'Toole S, Chemosensitivity Testing of Gynaecological Tumours, 1st International Postgraduate Student Conference., Dublin, 1998, 1998 Meeting Abstract, 1998

Research Expertise

Description

-Early diagnostics in ovarian cancer -Chemoresistance in ovarian cancer Chemosensitivity/Resistance testing of malignant gynaecological tumours -Examination of Fibrinolytic systems of malignant gynaecological tumours -Examination of angiogenesis in ovarian cancers. -Examination of multidrug resistance genes in gynaecological tumours. -Estrogen regulated genes in endometrial cancer. -PhytoSERMs and Endometrial Cancer

Keywords

Gynaecology oncology; Obstetrics/Gynecology; Oestregens in age related urogenital diseases

Recognition

Memberships

Member of European Association for Cancer Research. Member of Irish Association for Cancer Research

-Co-ordinator of INNOVATION- the Irish National Network for Ovarian Cancer Collaboration.

-Executive Committee of the Irish Society of Gynaecological Oncology (ISGO)

-Member of the European Society for Gynaecological Oncology (ESGO)

-Member of Cancer Trials Ireland