Dr. James Phelan
Research Fellow, Trinity Translational Medicine Institute
Publications and Further Research Outputs
Peer-Reviewed Publications
Noel E Donlon, Maria Davern, Fiona O'Connell, Andrew Sheppard, Aisling Heeran, Anshul Bhardwaj, Christine Butler, Ravi Narayanasamy, Claire Donohoe, James J Phelan, Niamh Lynam-Lennon, Margaret R Dunne, Stephen Maher, Jacintha O'Sullivan, John V Reynolds and Joanne Lysaght, The impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma, World Journal of Gastroenterology, 2022
Cilian Ó Maoldomhnaigh, Donal J Cox, James J Phelan, Fergal D Malone, Joseph Keane, Sharee A Basdeo, The Warburg Effect Occurs Rapidly in Stimulated Human Adult but Not Umbilical Cord Blood Derived Macrophages, Frontiers in Immunology, 2021
Phelan JJ, O'Leary S, Keane J., Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy, The Journal of Clinical Investigation, 2021
Abigail Keogan, Thi Nguyet Que Nguyen, James J. Phelan, Niamh Lynam-Lennon, C. Muldoon, A. A. Maguire, D. O'Toole, John V. Reynolds, Jacintha O'Sullivan, Aidan D Meade., Chemical imaging and machine learning for sub-classification of oesophageal tissue histology, Translational Biophotonics, 2021
Cahill, C. and Oâ connell, F. and Gogan, K.M. and Cox, D.J. and Basdeo, S.A. and Oâ sullivan, J. and Gordon, S.V. and Keane, J. and Phelan, J.J., The iron chelator desferrioxamine increases the efficacy of bedaquiline in primary human macrophages infected with bcg, International Journal of Molecular Sciences, 22, (6), 2021, p1-15
Christina Cahill, Fiona O'Connell, Karl M Gogan, Donal J Cox, Sharee A Basdeo, Jacintha O'Sullivan, Stephen V Gordon , Joseph Keane, James J Phelan, The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG, International Journal of Molecular Sciences, 2021
Cahill, C. and Cox, D.J. and Oâ connell, F. and Basdeo, S.A. and Gogan, K.M. and Ã"â maoldomhnaigh, C. and Oâ sullivan, J. and Keane, J. and Phelan, J.J., The effect of tuberculosis antimicrobials on the immunometabolic profiles of primary human macrophages stimulated with mycobacterium tuberculosis, International Journal of Molecular Sciences, 22, (22), 2021
Christina Cahill, Dónal J. Cox, Fiona O'Connell, Sharee A. Basdeo, Karl M. Gogan, Cilian Ó'Maoldomhnaigh, Jacintha O'Sullivan, Joseph Keane and James J. Phelan., The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis, International Journal of Molecular Sciences, 2021
James J. Phelan and Frederick J. Sheedy., Phagocyte metabolism: neutrophils have their cake but don't eat it., Trends in Immunology, 2021
Donlon, N.E. and Davern, M. and Sheppard, A. and Power, R. and Oâ connell, F. and Heeran, A.B. and King, R. and Hayes, C. and Bhardwaj, A. and Phelan, J.J. and Dunne, M.R. and Ravi, N. and Donohoe, C.L. and Oâ sullivan, J. and Reynolds, J.V. and Lysaght, J., The prognostic value of the lymph node in oesophageal adenocarcinoma; incorporating clinicopathological and immunological profiling, Cancers, 13, (16), 2021
Noel E Donlon, Maria Davern, Andrew Sheppard, Robert Power, Fiona O'Connell, Aisling B Heeran, Ross King, Conall Hayes, Anshul Bhardwaj, James J Phelan, Margaret R Dunne, Narayanasamy Ravi, Claire L Donohoe, Jacintha O'Sullivan, John V Reynolds, Joanne Lysaght., The Prognostic Value of the Lymph Node in Oesophageal Adenocarcinoma; Incorporating Clinicopathological and Immunological Profiling, Cancers, 2021
Cilian Ó Maoldomhnaigh, Donal J Cox, James Joseph Phelan, Karl M. Gogan, Kate McQuaid, Amy Martina Coleman, Sharee Ann Basdeo and Joseph Keane., Lactate alters metabolism in human macrophages and improves their ability to kill Mycobacterium tuberculosis, Frontiers in Immunology, 2021
Cox, D.J., Coleman, A.M., Gogan, K.M., Phelan, J.J., Maoldomhnaigh, C., Dunne, P.J., Basdeo, S.A. and Keane, J., Inhibiting histone deacetylases in human macrophages promotes glycolysis, IL-1β and T helper cell responses to Mycobacterium tuberculosis, Frontiers in Immunology, 2020
Cahill, C.*, Phelan, J.J.* and Keane, J, Understanding and exploiting the effect of tuberculosis antimicrobials on host mitochondrial function and bioenergetics, Frontiers in Cellular and Infection Microbiology, 2020
Phelan J.J., McQuaid, K., Kenny C., Gogan K.M., Cox D.J., Basdeo S.A., O'Leary S., Tazoll S.C., Ó Maoldomhnaigh C., O'Sullivan M.P., O'Neill LA, O'Sullivan M.J. & Keane J., Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis, Frontiers in Immunology, 2020
Noel E. Donlon and Andrew Sheppard and Maria Davern and Fiona O'Connell and James J. Phelan and Robert Power and Timothy Nugent and Kate Dinneen and John Aird and John Greene and Paul Nevins Selvadurai and Anshul Bhardwaj and Emma K. Foley and Narayanasamy Ravi and Claire L. Donohoe and John V. Reynolds and Joanne Lysaght and Jacintha O'Sullivan and Margaret R. Dunne, Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma"An Emerging Role for Chemokines, Cancers, 12, (11), 2020, p3356
Dunne M.R.*, Phelan J.J.*, Michielsen A.J., Maguire A.A., Dunne C., Martin P., Noonan S., Tosetto M., Geraghty R., Fennelly D., Sheahan K., Ryan E.J., O'Sullivan J. (joint 1st author *), Characterising the prognostic potential of HLA-DR during colorectal cancer development., Cancer Immunology Immunotherapy, 2020
Gillian Barber, Akanksha Anand, Katarzyna Oficjalska, James J Phelan, Aisling B Heeran, Ewelina Flis, Niamh E Clarke, Jenny A Watson, Julia Strangmann, Brian Flood, Hazel O'Neill, Dermot O'Toole, Finbar MacCarthy, Narayanasamy Ravi, John V Reynolds, Elaine W Kay, Michael Quante, Jacintha O'Sullivan, Emma M Creagh, Characterizing caspase‑1 involvement during esophageal disease progressio, Cancer Immunology, Immunotherapy, 2020
Petrasca A, Phelan J.J., Ansboro S, Veale D.J., Fearon U., Fletcher J.M., Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis., Rheumatology, 2020
Naoimh J. O'Farrell, James J. Phelan, Ronan Feighery, Brendan Doyle, Sarah L. Picardo, Ravi Narayanasamy, Dermot O'Toole, John V. Reynolds, Jacintha O'Sullivan, Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett's esophagus compared to esophageal adenocarcinoma, International Journal of Molecular Sciences, 2019
Melo, Ashanty M., O'Brien, Aisling M., Phelan, James J., Kennedy, Susan A., Wood, Nicole A. W., Veerapen, Natacha, Besra, Gurdyal S., Clarke, Niamh E., Foley, Emma K., Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V., Conroy, Melissa J., Hogan, Andrew E., O'Sullivan, Jacintha, Dunne, Margaret R., Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma, Frontiers in Immunology, 10, 2019
Francesco Caiazza, Katarzyna Oficjalska, Miriam Tosetto, James J. Phelan, SinéadNoonan, Petra Martin, Kate Killick, Laura Breen, Fiona O'Neill, Blathnaid Nolan, Simon Furney, Robert Power, David Fennelly, Charles S. Craik, Jacintha O'Sullivan, Kieran Sheahan, Glen A. Doherty, Elizabeth J. Ryan, KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment, The American Journal of Pathology, 2019
Phelan JJ, Basdeo SA, Tazoll SC, McGivern S, Saborido JR and Keane J, Modulating Iron for Metabolic Support of TB Host Defense, Frontiers in Immunology, 2018
Phelan, J.J. and Maccarthy, F. and Oâ toole, D. and Ravi, N. and Reynolds, J.V. and Oâ sullivan, J., The mitochondrial genes BAK1, FIS1 and SFN are linked with alterations in mitochondrial membrane potential in Barrettâ s esophagus, International Journal of Molecular Sciences, 19, (11), 2018
James J. Phelan, Finbar MacCarthy, Dermot O'Toole, Narayanasamy Ravi, John V. Reynolds and Jacintha O'Sullivan, The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett's Esophagus, International Journal of Molecular Sciences, 19, (11), 2018
Widdowson, W.M., McGowan, A., Phelan, J.J., Boran, G., Reynolds, J.V., and Gibney, J., Vascular disease is associated with the expression of genes for intestinal cholesterol transport and metabolism, Journal of Clinical Endocrinology & Metabolism, 102, (1), 2017, p326-335
Dowling CM, Hayes SL, Phelan J.J., Cathcart MC, Finn SP, Mehigan B, McCormick P, Coffey JC, O'Sullivan J and Kiely PA, Expression of protein kinase C gamma promotes cell migration in colon cancer, Oncotarget, 8, (42), 2017, p72096-72107
O'Farrell NJ, Feighery R, Picardo SL, Lynam-Lennon, N., Biniecka, M., McGarrigle, S., Phelan J.J., MacCarthy, F., O'Toole, D., Fox EJ, Ravi, N., Reynolds JV, O'Sullivan JN., 'Changes in mitochondrial stability during the progression of the Barrett's esophagus sequence'., BMC Cancer, 2016
Dowling C, Phelan J, Cathcart M, Mehigan B, McCormick P, Dalton T, Coffey C, Newton A, O'Sullivan J and Kiely P., Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival, Oncotarget, 7, 2016, p20919-20933
Phelan JJ, Feighery R, Eldin OS, Meachair SÓ, Cannon A, Byrne R, MacCarthy F, O'Toole D, Reynolds JV, O'Sullivan J, Examining the connectivity between different cellular processes in the Barrett tissue microenvironment., Cancer letters, 371, (2), 2016, p334-46
Biniecka, M., Canavan, M., McGarry, T., Gao, W., McCormick, J., Cregan, S., Gallagher, L., Smith T., Phelan, J.J., Ryan, J., O'Sullivan, J., Nq, C.T., Veale, D.J. and Fearon, U., 'Dysregulated bioenergetics: a key regulator of joint inflammation'., Annals of Rheumatic diseases., 75, (12), 2016, p2192-2200
Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200
O'Farrell N.J, Feighery R, Picardo S.L, Lynam-Lennon N, Biniecka M, McGarrigle S.A, Phelan J.J, MacCarthy F, O'Toole D, Fox E.J, Ravi N, Reynolds J.V, O'Sullivan J, Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence, BMC Cancer, 16, (1), 2016, p497-
Dowling, C.M., Phelan, J.J., Callender, J.A., Cathcart, M.C., Mehigan, B., McCormick, P., Dalton, T., Coffey, J.C. Newton A.C., O'Sullivan, J. and Kiely P.A., 'Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival'., Oncotarget, 7, (15), 2016, p20919 - 20933
Phelan, J.J., Feighery, R., Eldin, O.S., MacCarthy, F., O'Toole, D., Reynolds, J.V. and O'Sulllivan, J., 'Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity'., Cancer Letters, 371, (2), 2016, p334 - 346
Phelan JJ, O'Hanlon C, Reynolds JV, O'Sullivan J., 'The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'., Gastro Open Journal, 1, (2), 2015, p44-58
Lynam-Lennon, N., Maher, S.G., Maguire, A., (...), Reynolds, J.V., O'Sullivan, J., Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE , 9, (6), 2014, pe100738-
Phelan JJ, MacCarthy F, Feighery R, O'Farrell NJ, Lynam-Lennon N, Doyle B, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J., Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus'., Cancer Letters, 354, (1), 2014, p122 - 131
O'Sullivan KE, Phelan JJ, O'Hanlon C, Lysaght J, O'Sullivan JN, Reynolds JV., The role of inflammation in cancer of the esophagus. Expert review of gastroenterology & hepatology., Expert review of gastroenterology & hepatology, 8, (7), 2014, p749 - 760
O'Sullivan KE, Phelan JJ, O'Hanlon C, Lysaght J, O'Sullivan JN, Reynolds JV., The role of inflammation in cancer of the esophagus., Expert Reviews Gastroenterology Hepatology, 8, (7), 2014, p749 - 760
Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J., 'Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma'., PLOS ONE, 9, (6), 2014
Research Expertise
Projects
- Title
- Evaluating the immunometabolic potential of desferrioxamine to augment antibiotic treatment against Mycobacterium tuberculosis
- Summary
- Tuberculosis (TB) remains a global scourge causing more than one million deaths annually. TB therapy is characterised by a long duration of treatment and the administration of a number of antibiotic drugs to overcome drug resistance. The increasing prevalence of drug-resistant TB demonstrates that current treatments are inadequate and there is an urgent need for novel therapies. Research is now focused on the development of host-directed therapies (HDTs) which can be used in combination with existing antimicrobials, with a special focus on promoting host defense, particularly cellular metabolism. Immunometabolic reprogramming is integral to TB host defense and fundamental to eradicating TB infection. Moreover, TB pathophysiology is interconnected with iron metabolism. Iron is crucial for the survival of Mycobacterium tuberculosis (Mtb), the bacteria that causes TB disease. Iron chelation has therefore been suggested as a HDT. In addition to its direct effects on iron availability, it is hypothesised that iron chelators can also enhance immunometabolism through the stabilisation of HIF1α. We propose to evaluate the immunometabolic potential of anti-TB agents in combination with the iron chelator, desferrioxamine (DFX), to examine if such anti-TB/DFX combinatorial agents can augment antibiotic efficacy in human alveolar macrophages infected with clinical isolates of drug-resistant Mtb.
- Funding Agency
- Science Foundation Ireland
- Date From
- 1st April 2019
- Date To
- 31st March 2020
Recognition
Representations
I have presented six posters at international conferences including the BSI (2017, Brighton), the 7th & 9th National Barrett's Symposium (2013 &2015, London), Keystone's Tumor Metabolism Conference (2014, Canada), at the European Association of Cancer Research (EACR23) (2014, Munich) and at Abcam's Cancer and Metabolism Conference (2013, Amsterdam).
Awards and Honours
British Society for Immunology - Travel Award (£1000)
SFI/EI Technology Innovation Development Award (TIDA) (127,349.00)
Irish Research Council Government of Ireland Postdoctoral Fellowship (91,970.00)