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Dr. Eva Palsson Mcdermott
Research Fellow, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379 Journal Article, 2016 URL TARA - Full Text

Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 Journal Article, 2016 DOI URL TARA - Full Text

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80 Journal Article, 2015 DOI TARA - Full Text

Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347 Miscellaneous, 2015 DOI

Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 Journal Article, 2014 DOI TARA - Full Text

Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ Journal Article, 2013 DOI TARA - Full Text

Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nature Immunology, 11, (2), 2010, p141-147 Journal Article, 2010 DOI

Palsson-McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock , Espevik T and O'Neill LAJ, TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling, Nature Immunology, 10, 2009, p579 - 586 Journal Article, 2009 DOI

McCoy CE, Carpenter S, Palsson-McDermott EM, Gearing J, O'Neill, LA, Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like, The Journal of Biological Chemistry, 283, 2008, p14277-14285 Journal Article, 2008 TARA - Full Text DOI

Pålsson-McDermott EM, O'Neill LA., The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60 Journal Article, 2007 URL DOI

Palsson-McDermott EM, O'Neill, LA. , Building an immune system from nine domains., Biochem Soc Trans., 35, (6), 2007, p1437-44 Review, 2007 URL

Palsson-McDermott EM, O'Neill LA. , The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60 Review, 2007 DOI URL

Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377 Journal Article, 2007 DOI TARA - Full Text

McGettrick, A, Brint EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay NJ, Fitzgerald, KA and O'Neill LA, Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling, Proceedings of the National Academy of Sciences , 103, (24), 2006, p9196 - 9201 Journal Article, 2006 TARA - Full Text DOI

Palsson-McDermott EM and O'Neill LA, Signal transduction by the lipopolysacchride receptor Toll-like receptor-4, Immunology, 113, (2), 2004, p153 - 162 Journal Article, 2004

E. M. Palsson-McDermott and L. A. O'Neill, Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4, Immunology, 113, (2), 2004, p153-62 Journal Article, 2004 DOI TARA - Full Text

Eva Palsson-McDermott and Luke A.J. O'Neill, Ras participates in the activation of p38 MAPK by Interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1, The Journal of Biological Chemistry, 277, (10), 2002, p7808 - 7815 Journal Article, 2002 URL

Fitzgerald KA, Palsson-McDermott EM, et al, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78 - 83 Journal Article, 2001

K. A. Fitzgerald, E. M. Palsson-McDermott, A. G. Bowie, C. A. Jefferies, A. S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, M. T. Harte, D. McMurray, D. E. Smith, J. E. Sims, T. A. Bird and L. A. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78-83 Journal Article, 2001 DOI URL URL

Eva M Palsson,Michael Popoff, Monica Thelestam,Luke O'Neill, Divergent Roles for Ras and Rap in the Activation of p38 MAPK by Interleukin-1, The Journal of Biological Chemistry, 275, (11), 2000, p7818 - 7825 Journal Article, 2000 URL

E. M. Palsson, M. Popoff, M. Thelestam and L. A. O'Neill, Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1, The Journal of Biological Chemistry, 275, (11), 2000, p7818-7825 Journal Article, 2000 URL TARA - Full Text

O'Neill LA, Matthews JS, Pålsson E, Jeffries C, Brennan P, Cantrell DA., Interleukin 1 signalling: synergy with Rac1 and Pi3 kinase., Biochemical Society Transactions, 25, (4), 1998, pS578 - S578 Journal Article, 1998

O'Neill LA, Matthews JS, Palsson EM, Jeffries C, Brennan P, Cantrell DA, Interleukin1 signalling: synergy with Rac1 and Pi3 kinase, Biochem Soc Trans, Nov, (25), 1997, pS578- Journal Article, 1997