Dr. Barry Moran
Snr Experimental Officer, Biochemistry
Publications and Further Research Outputs
Peer-Reviewed Publications
Katie Ridge, Barry Moran, Mark A. Little, Cliona O"Farrelly, Jean Dunne, Julianne Clowry, Clodagh Loftus, Conor M. Finlay, Alan D. Irvine, Niall Conlon, Myeloid and Mast Cell Progenitors Are Elevated in Atopic Dermatitis, JID Innovations, 5, (5), 2025, p100390 - 100390, p100390-100390
O'Neill, Eoin and Curham, Lucy and NÃ Chasaide, CaitlÃn and O'Brien, SÃofra and McManus, Gavin and Moran, Barry and Rubin, Keith and Glazer, Steven and Lynch, Marina A. and Mills, Kingston H.G., Neonatal infection with Bordetella pertussis promotes autism-like phenotypes in mice, iScience, 28, (1), 2025
Ryan KM, O'Rourke A, Sheridan C, Balcells Quintana M, Moran B, Fletcher JM, McLoughlin DM, Harkin A., Flow-cytometric analysis of immune cell populations in patients with depression: relationship with depression severity and electroconvulsive therapy therapeutic outcomes., Frontiers in cellular neuroscience, 19, 2025, p1693999
Vasile Mihai Sularea, Liam Townsend, Cian Reid, Andreea V Atanasescu, Adam H. Dyer, Federica Giangrazi, Roman Rocha Lawrence, Manoj Sivan, Barry Moran, Derek G. Doherty, Niall Conlon, Aideen Long, Cliona O"Farrelly, Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential, Open Forum Infectious Diseases, 12, (11), 2025, pofaf447 - ofaf447, pofaf447-ofaf447
Nà Chasaide, CaitlÃn and Schmitt, Pauline and Diallo, Béré K. and Borkner, Lisa and Leane, Charlotte M. and Jazayeri, Seyed Davoud and Udayan, Sreeram and O'Neill, Eoin and Curham, Lucy M. and Moran, Barry and Wilk, Mieszko M. and Mills, Kingston H. G., Acellular Pertussis Vaccines Induce CD8+ and CD4+ Regulatory T Cells That Suppress Protective Tissue-Resident Memory CD4+ T Cells, in Part via IL-10, European Journal of Immunology, 55, (7), 2025
Katie Ridge, Rizwan Ahmad, Barry Moran, Cliona O"Farrelly, Jean Dunne, Conor M. Finlay, Alan D. Irvine, Niall Conlon, Towards Personalised Therapy in Chronic Spontaneous Urticaria: Advancing From Endotype to Clinical Response, Clinical & Experimental Allergy, 55, (11), 2025, p1070 - 1082, p1070-1082
Megan M. Hanlo, Conor M. Smith, Mary Canavan , Nuno G. B. Neto , Qingxuan Song, Myles J. Lewis , Aoife M. O"Rourke, Orla Tynan, Brianne E. Barker, Phil Gallagher, Ronan Mullan, Conor Hurson, Barry Moran , Michael G. Monaghan, Costantino Pitzalis, Jean M. Fletcher, Sunil Nagpal, Douglas J. Veale, and Ursula Fearon, Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset, Science Advances, 2024
Leane, C.M. and Sutton, C.E. and Moran, B. and Mills, K.H.G., PD-1 regulation of pathogenic IL-17-secreting γΎ T cells in experimental autoimmune encephalomyelitis, European Journal of Immunology, 2024
Katie Ridge, Barry Moran, Mark A. Little, Cliona O"Farrelly, Jean Dunne, Julianne Clowry, Clodagh Loftus, Conor M. Finlay, Alan D. Irvine, Niall Conlon, Lin-CD117+CD34+FceRI+ progenitor cells are elevated in atopic dermatitis, 2024
Ridge, K., Moran, B., Alvarado-Vazquez, P.A., Hallgren, J., Little, M.A., Irvine, A.D., O'Farrelly, C., Dunne, J., Finlay, C.M., Conlon, N., Lin"CD117+CD34+Fc"RI+ progenitor cells are increased in chronic spontaneous urticaria and predict clinical responsiveness to anti-IgE therapy, Allergy: European Journal of Allergy and Clinical Immunology, 2024
Leacy EJ, Teh JW, O'Rourke AM, Brady G, Gargan S, Conlon N, Scott J, Dunne J, Phelan T, Griffin MD, Power J, Mooney A, Naughton A, Kiersey R, Gardiner M, O'Brien C, Mullan R, Flood R, Clarkson M, Townsend L, O'Shaughnessy M, Dyer AH, Moran B, Fletcher JM, Zgaga L, Little MA, RITA Ireland Vasculitis Biobank., Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination., International journal of molecular sciences, 25, (10), 2024, p5239
Petrasca Andreea, Hambly R, Molloy O, Kearns S, Moran B, Smith CM, Hughes R, O'Donnell M, Zaborowski A, Winter D, Fletcher JM, Kirby B, Malara A., Innate lymphoid cell (ILC) subsets are enriched in the skin of patients with hidradenitis suppurativa., PloS one, 18, (2), 2023, pe0281688
Gaynor N, Blanco A, Madden SF, Moran B, Fletcher JM, Kaukonen D, Ramírez JS, Eustace AJ, McDermott MSJ, Canonici A, Toomey S, Teiserskiene A, Hennessy BT, O'Donovan N, Crown J, Collins DM., Alterations in immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients receiving HER2-targeted neo-adjuvant therapy., British journal of cancer, 129, (6), 2023, p1022-1031
Moran B, Smith CM, Zaborowski A, Ryan M, Karman J, Dunstan RW, Smith KM, Hambly R, Musilova J, Petrasca A, Fabre A, O'Donnell M, Hokamp K, Mills KHG, Housley WJ, Winter DC, Kirby B, Fletcher JM (, Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin, British Journal of Dermatology, 189, (4), 2023, p447-458
M. Hanlon, Mary Canavan, Nuno Neto, Qingxuan Song, P. Gallagher, Ronan Mullan, Conor Hurson, Barry Moran, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon, OP0013 LOSS OF SYNOVIAL TISSUE MACROPHAGE HOMEOSTASIS PRECEDES RHEUMATOID ARTHRITIS CLINICAL ONSET, Annals of the Rheumatic Diseases, 81, (Suppl 1), 2022, p8.1 - 8, p8.1-8
Sulaimani Jamal, Cluxton Deborah, Clowry J, Petrasca Andreea, Molloy OE, Moran B, Sweeney CM, Malara A, McNicholas N, McGuigan C, Kirby Brian, Fletcher Jean M., Dimethyl fumarate modulates the Treg-Th17 cell axis in patients with psoriasis., The British journal of dermatology, 2021
Borkner L, Curham LM, Wilk MM, Moran B, Mills KHG., IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils., Mucosal immunology, 2021
Anindya Mukhopadhya, Jessie Santoro, Barry Moran, Zivile Useckaite, Lorraine O'Driscoll , Optimisation and comparison of orthogonal methods for separation and characterisation of extracellular vesicles to investigate how representative infant milk formula is of milk, Food Chemistry, 353, 2021, p129309-
Nicola Gaynor, Alfonso Blanco, Alexandra Canonici, Alex J. Eustace, Martina S.J. McDermott, Barry Moran, Jean M. Fletcher, Norma O"Donovan, John Crown, Denis M. Collins, Abstract 951: The effect of neo-adjuvant chemotherapy on immune cell phenotype and cytotoxic capacity in HER2+ breast cancer patients, Cancer Research, 80, (16_Supplement), 2020, p951 - 951, p951-951
Fletcher JM, Moran B, Petrasca A, Smith CM., IL-17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa., Clinical and experimental immunology, 201, (2), 2020, p121-134
Floudas A, Neto N, Marzaioli V, Murray K, Moran B, Monaghan MG, Low C, Mullan RH, Rao N, Krishna V, Nagpal S, Veale DJ, Fearon U., Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint., JCI insight, 5, (21), 2020
Lecordier L, Uzureau S, Vanwalleghem G, Deleu M, Crowet JM, Barry P, Moran B, Voorheis P, Dumitru AC, Yamaryo-Botté Y, Dieu M, Tebabi P, Vanhollebeke B, Lins L, Botté CY, Alsteens D, Dufrêne Y, Pérez-Morga D, Nolan DP, Pays E., The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity., iScience, 23, (9), 2020, p101476
Useckaite Z, Mukhopadhya A, Moran B, O'Driscoll L., Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation., Scientific reports, 10, (1), 2020, p19020
Anindya Mukhopadhya, Jessie Santoro, Barry Moran, Zivile Useckaite, Lorraine O"Driscoll, Optimisation and comparison of orthogonal methods for separation and characterisation of extracellular vesicles to investigate how representative infant milk formula is of milk, 2020
Edwards, S.C. and Sutton, C.E. and Ladell, K. and Grant, E.J. and McLaren, J.E. and Roche, F. and Dash, P. and Apiwattanakul, N. and Awad, W. and Miners, K.L. and Lalor, S.J. and Ribot, J.C. and Baik, S. and Moran, B. and McGinley, A. and Pivorunas, V. and Dowding, L. and Macoritto, M. and Paez-Cortez, J. and Slavin, A. and Anderson, G. and Silva-Santos, B. and Hokamp, K. and Price, D.A. and Thomas, P.G. and McLoughlin, R.M. and Mills, K.H.G., A population of proinflammatory T cells coexpresses αβ and γΎ T cell receptors in mice and humans, Journal of Experimental Medicine, 217, (5), 2020
Aisling Ui Mhaonaigh, Alice M. Coughlan, Amrita Dwivedi, Aisling Morrin, Vincent O"Reilly, Fionnuala B. Hickey, Barry Moran, Joana Cabral, Mark A. Little, 054."LOW DENSITY GRANULOCYTES IN ANCA VASCULITIS: PHENOTYPE AND FUNCTION, Lara D. Veeken, 58, (Supplement_2), 2019
Moran B, Gallagher C, Tobin AM, Fletcher JM., Enrichment of polyfunctional IL-17 producing T cells in paradoxical psoriasis skin lesions., The Journal of investigative dermatology, 2019
J. Musilova, B. Moran, C.M. Sweeney, A. Malara, A. Zaborowski, R. Hughes, D.C. Winter, J.M. Fletcher, B. Kirby, Enrichment of Plasma Cells in the Peripheral Blood and Skin of Patients with Hidradenitis Suppurativa, Journal of Investigative Dermatology, 2019
Ui Mhaonaigh, A. and Coughlan, A.M. and Dwivedi, A. and Hartnett, J. and Cabral, J. and Moran, B. and Brennan, K. and Doyle, S.L. and Hughes, K. and Lucey, R. and Floudas, A. and Fearon, U. and McGrath, S. and Cormican, S. and De Bhailis, A. and Molloy, E.J. and Brady, G. and Little, M.A., Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies, Frontiers in Immunology, 10, (2603), 2019
Cluxton D, Petrasca A, Moran B, Fletcher JM, Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis, Frontiers in Immunology, 10, 2019, p115-
Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U, Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis., JCI Insight, 3, (23), 2018, p95228-
Barry Moran, Cheryl M. Sweeney, Rosalind Hughes, Anna Malara, Shivashini Kirthi, Anne-Marie Tobin, Brian Kirby, Jean M. Fletcher, Hidradenitis Suppurativa Is Characterized by Dysregulation of the Th17:Treg Cell Axis, Which Is Corrected by Anti-TNF Therapy, Journal of Investigative Dermatology, 137, (11), 2017, p2389--2395
Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells., J immunology, 198 , (2), 2017, p2249 - 2259
Mary Canavan, Trudy McGarry, Kate E. Killick, Barry Moran, Deborah Cluxton, Carl Orr, Siobhan Wade, Hannah Convery, S Wade, Ronan Mullan, Jean M. Fletcher, Douglas J. Veale, Ursula Fearon, 01.04"Enrichment of activated cd141+ dendritic cells in inflammatory arthritis, Annals of the Rheumatic Diseases, 76, 2017, pA2 - A2, pA2-A2
Mary Canavan, Trudy McGarry, Kate E. Killick, Barry Moran, Deborah Cluxton, C. Orr, Hannah Convery, S Wade, S Wade, Ronan Mullan, Jean M. Fletcher, Douglas J. Veale, Ursula Fearon, SAT0013"The pathogenic role of myeloid CD141+ dendritic cells in inflammatory arthritis, Annals of the Rheumatic Diseases, 76, 2017, p773 - 773, p773-773
Leila Smith, Barry Moran, Helen Rea, Mathilde Raverdeau, Ian A. McDonald, Kingston H. G. Mills, Martin Steinhoff, 268 Expression of Interleukin-33 by resident and immune cells in the skin of patients with atopic dermatitis, Journal of Investigative Dermatology, 136, (9), 2016, pS207 - S207, pS207-S207
Basdeo, S.A., Moran, B., Cluxton, D., (...), Fearon, U., Fletcher, J.M., Polyfunctional, pathogenic CD161+ Th17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity, Journal of Immunology, 195, (2), 2015, p528-540
Mothiram U, Brennan PC, Lewis SJ, Moran B, Robinson J, Digital radiography exposure indices: A review., Journal of medical radiation sciences, 61, (2), 2014, p112-8
Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80
Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282
Marie Yang, Kevin Flavin, Ilona Kopf, Gábor Radics, Claire H. Hearnden, Gavin McManus, Barry Moran, Adrián Villalta"Cerdas, Luís Echegoyen, Silvia Giordani, Ed C. Lavelle, Carbon Nanotubes: Functionalization of Carbon Nanoparticles Modulates Inflammatory Cell Recruitment and NLRP3 Inflammasome Activation (Small 24/2013), Small, 9, (24), 2013, p4280 - 4280, p4280-4280
Yang, M., Flavin, K., Kopf, I., Radics, G., Hearnden, C.H.A., McManus, G.J., Moran, B., Villalta-Cerdas, A., Echegoyen, L.A., Giordani, S., Lavelle, E.C., Functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation, Small, 9, (24), 2013, p4194-4206
Moran B, Blanco-Fernández A, Gardner R, Tigges J, Toxavidis V, Daley JF, Remote access technology offers tremendous possibilities to the cytometry community., Cytometry. Part A : the journal of the International Society for Analytical Cytology, 83, (12), 2013, p1062-5
Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424
Coleman, M.M., Finlay, C.M., Moran, B., Keane, J., Dunne, P.J., Mills, K.H., The immunoregulatory role of CD4 +FoxP3 +CD25 - regulatory T cells in lungs of mice infected with Bordetella pertussis, FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413-424
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC, Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4., PLoS pathogens, 6, (11), 2010, pe1001191
Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH, CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis., Journal of Immunology , 183, (11), 2009, p7602-7610
Dunne PJ, Moran B, Cummins RC and Mills KH , CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. , The Journal of Immunology, 183, 2009, p400 - 410
Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, Tubridy N and Mills KHG, CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis, Journal of Immunology, 183, 2009, p7602 - 7610
Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C and Mills KHG, Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta, Journal of Immunology, 181, (7), 2008, p4485 - 4494
Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky GA, Shattil SJ. , ADAP is required for normal {alpha}IIb{beta}3 activation by VWF/GP Ib-IX-V and other agonists., Blood , Vol 109, (3), 2007, p1018 - 1025
Soriani A, Moran B, De Virgilio M, Kawakami T, Altman A, Lowell C, Eto K and Shattil SJ, A role for PKCtheta in outside-in alphaIIb,beta3 signaling, Journal of Thrombosis and Haemostasis, 4, 2006, p648 - 655
Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, and Leavitt AD, Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function, Journal of Thrombosis and Haemostasis, 4, 2006, p436 - 442
Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, and Shattil SJ, PTP-1B is an essential positive regulator of platelet integrin signaling , Journal of Cell Biology, 170, (5), 2005, p837 - 845
Shields DC, Fitzgerald AP, O'Neill PA, Muckian C, Kenny D, Moran B, Cannon CP, Byrne CE, Fitzgerald DJ., The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists, Pharmacogenomics Journal, 2, (3), 2002, p182 - 190
Non-Peer-Reviewed Publications
Corrigan M, O'Rourke AM, Moran B, Fletcher JM, Harkin A., Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin., Neuronal Signal, 7, (2), 2023, pNS20220054-
Research Expertise
Description
Dr Barry Moran runs the Flow Cytometry Facility, within the Trinity Biomedical Sciences Institute. Flow cytometry is a complex technology used to interrogate the phenotype and function of cells in many areas of life science and biomedical research, including immunology and cancer. It involves sensitive, precision-based cellular analysis of multiple parameters on individual cells at incredibly high speeds. Millions of data points can be generated per second, requiring sophisticated analysis tools. Key infrastructure within TBSI's Flow Cytometry Facility include high-end platforms (high-speed cell sorter, imaging cytometer, high-dimensional spectral analyser) and four advanced cytometer analysers. Dr Moran has a particular interest in immune dysfunction in the skin, primarily in the disease hidradenitis suppurativa.Recognition
Memberships
International Society for Advancement of Cytometry
Royal Microscopical Society
Irish Society for Immunology
British Society for Immunology
Cytometry Society of Ireland