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Professor Seamus Martin
Smurfit Professor of Medical Genetics, Genetics


My lab works on the central mechanisms of apoptosis and how this programmed cell death process becomes dysregulated in disease states such as cancer and inflammation.

Our work is highly cited (>12,000 citations to date) and, based upon independent citation analyses conducted by the Institute for Scientific Information in Boston, USA, our lab ranks within the top 10 labs working in the Apoptosis/Cell Death field worldwide (receiving approx. 150 cites per paper on average).

We have published our research in Cell, EMBO J, Science, Nature, J. Exp. Med, JBC, Nature Medicine, as well as many other quality journals.

I am currently a Principal Investigator with Science Foundation Ireland (funded by a €5 million award in 2001) and our work is also supported by The Wellcome Trust (UK) as well as several other funding agencies.

My post-doctoral work was carried out with Dr. Doug Green (La Jolla Institute for Allergy & Immunology, San Diego, USA) and Prof. Ivan Roitt (University College London, UK). My PhD work was carried out with Prof. Tom Cotter, then at NUI Maytooth (now at UCC).

Publications and Further Research Outputs

Peer-Reviewed Publications

Boeltz S, Amini P, Anders H.-J, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy D.M, Desai J, Dumych T, Dwivedi N, Gordon R.A, Hahn J, Hidalgo A, Hoffmann M.H, Kaplan M.J, Knight J.S, Kolaczkowska E, Kubes P, Leppkes M, Manfredi A.A, Martin S.J, Maueröder C, Maugeri N, Mitroulis I, Munoz L.E, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic M.Z, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik M.J, Simon H.-U, Skendros P, Stojkov D, Vandenabeele P, Berghe T.V, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M, To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps, Cell Death and Differentiation, 26, (3), 2019, p395 - 408 Journal Article, 2019 DOI URL TARA - Full Text

Martin S.J, The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled, FEBS Journal, 286, (1), 2019, p4 - 7 Journal Article, 2019 DOI URL

Gemayel R, Martin S.J, How to prepare and deliver a great talk, FEBS Journal, 286, (1), 2019, p39 - 45 Journal Article, 2019 DOI URL TARA - Full Text

Sullivan, G.P. and Davidovich, P.B. and Sura-Trueba, S. and Belotcerkovskaya, E. and Henry, C.M. and Clancy, D.M. and Zinoveva, A. and Mametnabiev, T. and Garabadzhiu, A.V. and Martin, S.J., Identification of small-molecule elastase inhibitors as antagonists of IL-36 cytokine activation, FEBS Open Bio, 8, (5), 2018, p751-763 Journal Article, 2018 TARA - Full Text DOI

Martin S.J, A Guide to â€~A Guide to
.†articles, some thoughts on impact, and why you really should publish with The FEBS Journal, FEBS Journal, 285, (13), 2018, p2364 - 2366 Journal Article, 2018 DOI URL

Feltham, R. and Jamal, K. and Tenev, T. and Liccardi, G. and Jaco, I. and Domingues, C.M. and Morris, O. and John, S.W. and Annibaldi, A. and Widya, M. and Kearney, C.J. and Clancy, D. and Elliott, P.R. and Glatter, T. and Qiao, Q. and Thompson, A.J. and Nesvizhskii, A. and Schmidt, A. and Komander, D. and Wu, H. and Martin, S. and Meier, P., Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential, Cell Reports, 23, (2), 2018, p470-484 Journal Article, 2018 TARA - Full Text DOI

Sullivan G.P, Henry C.M, Clancy D.M, Mametnabiev T, Belotcerkovskaya E, Davidovich P, Sura-Trueba S, Garabadzhiu A.V, Martin S.J, Suppressing IL-36-driven inflammation using peptide pseudosubstrates for neutrophil proteases, Cell Death and Disease, 9, (3), 2018 Journal Article, 2018 URL DOI

Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin S.J, Steinberg F, Strisovsky K, Adrain C, ITap, a novel irhom interactor, controls TNF secretion by policing the stability of iRhom/TACE, eLife, 7, 2018 Journal Article, 2018 DOI TARA - Full Text URL

Clancy, D.M. and Sullivan, G.P. and Moran, H.B.T. and Henry, C.M. and Reeves, E.P. and McElvaney, N.G. and Lavelle, E.C. and Martin, S.J., Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing, Cell Reports, 22, (11), 2018, p2809-2817 Journal Article, 2018 TARA - Full Text DOI

Martin, S.J., The FEBS Journal in 2018 â€" putting a bit of color in your life, and your figures, FEBS Journal, 285, (1), 2018, p4-7 Journal Article, 2018 DOI

Galluzzi, L. and Vitale, I. and Aaronson, S.A. and Abrams, J.M. and Adam, D. and Agostinis, P. and Alnemri, E.S. and Altucci, L. and Amelio, I. and Andrews, D.W. and Annicchiarico-Petruzzelli, M. and Antonov, A.V. and Arama, E. and Baehrecke, E.H. and Barlev, N.A. and Bazan, N.G. and Bernassola, F. and Bertrand, M.J.M. and Bianchi, K. and Blagosklonny, M.V. and Blomgren, K. and Borner, C. and Boya, P. and Brenner, C. and Campanella, M. and Candi, E. and Carmona-Gutierrez, D. and Cecconi, F. and Chan, F.K.-M. and Chandel, N.S. and Cheng, E.H. and Chipuk, J.E. and Cidlowski, J.A. and Ciechanover, A. and Cohen, G.M. and Conrad, M. and Cubillos-Ruiz, J.R. and Czabotar, P.E. and D†Angiolella, V. and Dawson, T.M. and Dawson, V.L. and de Laurenzi, V. and de Maria, R. and Debatin, K.-M. and DeBerardinis, R.J. and Deshmukh, M. and Di Daniele, N. and Di Virgilio, F. and Dixit, V.M. and Dixon, S.J. and Duckett, C.S. and Dynlacht, B.D. and El-Deiry, W.S. and Elrod, J.W. and Fimia, G.M. and Fulda, S. and García-Sáez, A.J. and Garg, A.D. and Garrido, C. and Gavathiotis, E. and Golstein, P. and Gottlieb, E. and Green, D.R. and Greene, L.A. and Gronemeyer, H. and Gross, A. and Hajnoczky, G. and Hardwick, J.M. and Harris, I.S. and Hengartner, M.O. and Hetz, C. and Ichijo, H. and JÀÀttelÀ, M. and Joseph, B. and Jost, P.J. and Juin, P.P. and Kaiser, W.J. and Karin, M. and Kaufmann, T. and Kepp, O. and Kimchi, A. and Kitsis, R.N. and Klionsky, D.J. and Knight, R.A. and Kumar, S. and Lee, S.W. and Lemasters, J.J. and Levine, B. and Linkermann, A. and Lipton, S.A. and Lockshin, R.A. and López-Otín, C. and Lowe, S.W. and Luedde, T. and Lugli, E. and MacFarlane, M. and Madeo, F. and Malewicz, M. and Malorni, W. and Manic, G. and Marine, J.-C. and Martin, S.J. and Martinou, J.-C. and Medema, J.P. and Mehlen, P. and Meier, P. and Melino, S. and Miao, E.A. and Molkentin, J.D. and Moll, U.M. and Muñoz-Pinedo, C. and Nagata, S. and Nuñez, G. and Oberst, A. and Oren, M. and Overholtzer, M. and Pagano, M. and Panaretakis, T. and Pasparakis, M. and Penninger, J.M. and Pereira, D.M. and Pervaiz, S. and Peter, M.E. and Piacentini, M. and Pinton, P. and Prehn, J.H.M. and Puthalakath, H. and Rabinovich, G.A. and Rehm, M. and Rizzuto, R. and Rodrigues, C.M.P. and Rubinsztein, D.C. and Rudel, T. and Ryan, K.M. and Sayan, E. and Scorrano, L. and Shao, F. and Shi, Y. and Silke, J. and Simon, H.-U. and Sistigu, A. and Stockwell, B.R. and Strasser, A. and Szabadkai, G. and Tait, S.W.G. and Tang, D. and Tavernarakis, N. and Thorburn, A. and Tsujimoto, Y. and Turk, B. and Vanden Berghe, T. and Vandenabeele, P. and Vander Heiden, M.G. and Villunger, A. and Virgin, H.W. and Vousden, K.H. and Vucic, D. and Wagner, E.F. and Walczak, H. and Wallach, D. and Wang, Y. and Wells, J.A. and Wood, W. and Yuan, J. and Zakeri, Z. and Zhivotovsky, B. and Zitvogel, L. and Melino, G. and Kroemer, G., Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death and Differentiation, 2018, p1-56 Journal Article, 2018 TARA - Full Text DOI

Chenette, E.J. and Martin, S.J., 50 years of The FEBS Journal: looking back as well as ahead, FEBS Journal, 284, (24), 2017, p4162-4171 Journal Article, 2017 DOI

Gemayel, R. and Martin, S.J., Writing a successful fellowship or grant application, FEBS Journal, 284, (22), 2017, p3771-3777 Journal Article, 2017 DOI

Clancy, D.M. and Henry, C.M. and Sullivan, G.P. and Martin, S.J., Neutrophil extracellular traps can serve as platforms for processing and activation of IL-1 family cytokines, FEBS Journal, 284, (11), 2017, p1712-1725 Journal Article, 2017 DOI

Henry, C.M. and Martin, S.J., Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory †FADDosome†Complex upon TRAIL Stimulation, Molecular Cell, 65, (4), 2017, p715-729.e5 Journal Article, 2017 DOI

Iurlaro, R. and PÃ"schel, F. and León-Annicchiarico, C.L. and O'Connor, H. and Martin, S.J. and Palou-Gramón, D. and Lucendo, E. and Muñoz-Pinedo, C., Glucose deprivation induces ATF4-mediated apoptosis through TRAIL death receptors, Molecular and Cellular Biology, 37, (10), 2017, e00479-16 Journal Article, 2017 TARA - Full Text DOI

Martin, S.J., The FEBS Journal in 2017: quality is its own reward, FEBS Journal, 284, (1), 2017, p4-6 Journal Article, 2017 DOI

Kearney, C.J. and Martin, S.J., An Inflammatory Perspective on Necroptosis, Molecular Cell, 65, (6), 2017, p965-973 Journal Article, 2017 DOI

Clancy D.M, Martin S.J, Getting a gRIP on Flu by Casting the DAI, Cell Host and Microbe, 20, (5), 2016, p552 - 554 Journal Article, 2016 TARA - Full Text URL DOI

Chenette, E.J. and Martin, S.J., Words of Advice: for what it's worth, our tuppenceworth, FEBS Journal, 283, (21), 2016, p3856 Journal Article, 2016 DOI

Chipuk J.E, Martin S.J, Special Issue on Cell Death: Murder, mystery (and a little bit of mayhem) in Manhattan, FEBS Journal, 2016, p2565 - 2567 Journal Article, 2016 DOI URL

Clancy D.M, Henry C.M, Davidovich P.B, Sullivan G.P, Belotcerkovskaya E, Martin S.J, Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs, FEBS Open Bio, 6, (4), 2016, p338 - 348 Journal Article, 2016 DOI URL TARA - Full Text

Martin S.J, Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system, FEBS Journal, 2016, p2599 - 2615 Journal Article, 2016 URL DOI

Henry C.M, Sullivan G.P, Clancy D.M, Afonina I.S, Kulms D, Martin S.J, Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines, Cell Reports, 14, (4), 2016, p708 - 722 Journal Article, 2016 TARA - Full Text URL DOI

Cullen S.P, Kearney C.J, Clancy D.M, Martin S.J, Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis, Cell Reports, 11, (10), 2015, p1535 - 1548 Journal Article, 2015 URL DOI TARA - Full Text

Kearney CJ, Cullen SP, Tynan GA, Henry CM, Clancy D, Lavelle EC, Martin SJ, Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production., Cell death and differentiation, 22, 2015, p1313-1327 Journal Article, 2015 DOI

Galluzzi L, Pietrocola F, Bravo-San Pedro J.M, Amaravadi R.K, Baehrecke E.H, Cecconi F, Codogno P, Debnath J, Gewirtz D.A, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri M.C, Martin S.J, Penninger J, Piacentini M, Rubinsztein D.C, Simon H.-U, Simonsen A, Thorburn A.M, Velasco G, Ryan K.M, Kroemer G, Autophagy in malignant transformation and cancer progression, EMBO Journal, 34, (7), 2015, p856 - 880 Journal Article, 2015 URL DOI

Cullen SP, Martin SJ., Fas and TRAIL 'death receptors' as initiators of inflammation: Implications for cancer., Semin Cell Dev Biol., 39, 2015, p26-34 Journal Article, 2015 DOI

Afonina I.S, Müller C, Martin S.J, Beyaert R, Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme, Immunity, 42, (6), 2015, p991 - 1004 Journal Article, 2015 URL DOI

Martin S, Dudek-Peri- A.M, Maes H, Garg A.D, Gabrysiak M, Demirsoy S, Swinnen J.V, Agostinis P, Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells, Biochemical Pharmacology, 93, (3), 2015, p290 - 304 Journal Article, 2015 URL DOI

Martin S.J, The FEBS Journal in 2015: Onwards and upwards, FEBS Journal, 282, (1), 2015, p1 - 3 Journal Article, 2015 URL DOI

Kearney, C.J., Cullen,. S.P., Clancy, D., Martin, S. J., RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis, FEBS Journal, 281, (21), 2014, p4921-4934 Journal Article, 2014 TARA - Full Text DOI

Martin,Seamus J. S.J., The FEBS Journal: Passing the editorial baton, FEBS Journal, 281, (1), 2014, p1-2 Journal Article, 2014 DOI TARA - Full Text

C Muñoz-Pinedo and S J Martin, Autosis: A new addition to the cell death tower of babel, Cell Death and Disease, 5, (7), 2014, pe1319- Journal Article, 2014 TARA - Full Text DOI

Hollville,Ã milie E., Carroll,Richard G. R.G., Cullen,Sean P. S.P., Martin,Seamus J. S.J., Bcl-2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1-dependent mitophagy, Molecular Cell, 55, (3), 2014, p451-466 Journal Article, 2014 DOI TARA - Full Text

Galluzzi,Lorenzo L., Bravo-San Pedro,José Manuel Bravo San J.M.B.S., Vitale,Ilio I., Aaronson,S. A. S.A., Abrams,J. M. J.M., Adam,D. D., Alnemri,Emad S. E.S., Altucci,L. L., Andrews,David William A D.W.A., Annicchiarico-Petruzzelli,M. M., Baehrecke,Eric H. E.H., Bazán,Nicolás G. N.G., Bertrand,M. J. M.J., Bianchi,K. K., Blagosklonny,Mikhail V. M.V., Blomgren,K. K., Borner,Christoph M B C.M.B., Bredesen,Dale E. D.E., Brenner,C. C., Campanella,M. M., Candi,Eleonora E., Cecconi,F. F., Chan,F. K. F.K., Chandel,N. S. N.S., Cheng,E. H. E.H., Chipuk,Jerry E Edward J.E., Cidlowski,John Anthony J.A., Ciechanover,Aaron J. A.J., Dawson,T. M. T.M., Dawson,V. L. V.L., De Laurenzi,Vincenzo V., De Maria,Ruggero R., Debatin,K. M. K.M., Di Daniele,Nicola Di N.D., Dixit,V. M. V.M., Dynlacht,Brian David B.D., El-Deiry,Wafik S. W.S., Fimia,Gian María G.M., Flavell,R. A. R.A., Fulda,Simone S., Garrido,C. C., Gougeon,Marie Lise M.L., Green,Douglas R. D.R., Gronemeyer,Hinrich J. H.J., Hajnóczky,György G., Hardwick,J. M. J.M., Hengartner,Michael Otmar M.O., Ichijo,H. H., Joseph,B. B., Jost,P. J. P.J., Kaufmann,T. T., Kepp,Oliver O., Klionsky,Daniel J. D.J., Knight,Richard Austen R.A., Kumar,Sharad S., Lemasters,John J. J.J., Levine,B. B., Linkermann,Andreas A., Lipton,S. A. S.A., Lockshin,R. A. R.A., López-Otín,Carlos C., Lugli,Enrico E., Madeo,Frank F. F.F., Malorni,Walter W., Marine,Jean Christophe W J.C.W., Martin,Seamus J. S.J., Martinou,J. C. J.C., Medema,Jan Paul J.P., Meier,P. P., Melino,S. S., Mizushima,N. N., Möll,Ute M. U.M., Muñoz-Pinedo,Cristina C., Nuñez,G. G., Oberst,A. A., Panaretakis,Theocharis T., Penninger,Josef Martin J.M., Peter,M. E. M.E., Piacentini,Mauro M., Pinton,Paolo P., Prehn,Jochen H M J.H.M., Puthalakath,Hamsa H., Rabinovich,Gabriel Adrián G.A., Ravichandran,K. S. K.S., Rizzuto,Rosario R. R.R., Rodrigues,C. M. C.M., Rubinsztein,David C. D.C., Rudel,T. T., Shi,Y. Y., Simon,H. U. H.U., Stockwell,B. R. B.R., Szabadkai,György G., Tait,S. W. S.W., Tang,H. L. H.L., Tavernarakis,Nektarios N., Tsujimoto,Y. Y., Vanden Berghe,Tom T., Vandenabeele,Peter P., Villunger,A. A., Wagner,E. F. E.F., Walczak,H. H., White,E. E., Wood,W. G. W.G., Yuan,J. J., Zakeri,Z. Z., Zhivotovsky,Boris D. B.D., Melino,Gerry G., Kroemer,Guido G., Essential versus accessory aspects of cell death: recommendations of the NCCD 2015, Cell Death and Differentiation, 2014 Journal Article, 2014 DOI TARA - Full Text

Carroll,Richard G. R.G., Hollville,Ã milie E., Martin,Seamus S., Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1, Cell Reports, 9, (4), 2014, p1538-1553 Journal Article, 2014 TARA - Full Text DOI

Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ, Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells., Molecular cell, 49, 2013, p1-15 Journal Article, 2013 DOI TARA - Full Text

Henry,Conor M. C.M., Hollville,Ã milie E., Martin,Seamus J. S.J., Measuring apoptosis by microscopy and flow cytometry, Methods, 61, (2), 2013, p90-97 Journal Article, 2013 DOI

Kearney CJ, Sheridan C, Cullen SP, Tynan GA, Logue SE, Afonina IS, Vucic D, Lavelle EC, Martin SJ, Inhibitor of Apoptosis Proteins (IAPs) and Their Antagonists Regulate Spontaneous and Tumor Necrosis Factor (TNF)-induced Proinflammatory Cytokine and Chemokine Production., The Journal of biological chemistry, 288, (7), 2013, p4878-4890 Journal Article, 2013 DOI TARA - Full Text

Martin,Seamus J. S.J., Henry,Conor M. C.M., Distinguishing between apoptosis, necrosis, necroptosis and other cell death modalities, Methods, 61, (2), 2013, p87-89 Journal Article, 2013 DOI

Carroll RG, Martin SJ, Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You., Cancer cell, 23, (4), 2013, p425-426 Journal Article, 2013 DOI TARA - Full Text

Kearney,Conor J. C.J., Martin,Seamus J. S.J., Competition for growth factors: A lot more death with a little less Aktion, Cell Death and Differentiation, 20, (10), 2013, p1291-1292 Journal Article, 2013 DOI

Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., (...), Zuckerbraun, B., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, (4), 2012, p445-544 Review Article, 2012 DOI

Martin SJ, Henry CM, Cullen SP, A perspective on mammalian caspases as positive and negative regulators of inflammation., Molecular cell, 46, (4), 2012, p387-397 Journal Article, 2012 DOI TARA - Full Text

Hollville, E., Martin, S.J., Greasing the path to BAX/BAK activation, Cell, 148, (5), 2012, p845-846 Journal Article, 2012 DOI TARA - Full Text

Walsh JG, Logue SE, Luthi AU, Martin SJ, Caspase-1 promiscuity is counterbalanced by rapid inactivation of the processed enzyme., The Journal of Biological Chemistry, 286, (37), 2011, p32513-32524 Journal Article, 2011 TARA - Full Text DOI

Cullen SP, Henry CM, Martin SJ, Staying alive: defensive strategies in the BCL-2 family playbook., Molecular cell, 44, (4), 2011, p509-10 Journal Article, 2011 TARA - Full Text DOI

Afonina, I.S., Tynan, G.A., Logue, S. E., Cullen, S.P., Bots, M., Lüthi, A.U., Reeves, E.P., McElvaney, N.G., Medema, J.P., Lavelle, E.C. and Martin, S.J., Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1, Molecular Cell, 44, (2), 2011, p465 - 478 Journal Article, 2011 TARA - Full Text DOI

Elgendy, M, Sheridan, C, Brumatti, G, Martin, SJ, Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival, Molecular Cell, 42, (1), 2011, p23-35 Journal Article, 2011 TARA - Full Text DOI

Martin, S.J., Oncogene-induced autophagy and the Goldilocks principle, Autophagy, 7, (8), 2011, p922-923 Journal Article, 2011 TARA - Full Text

Martin, S.J. , Mitochondrial fusion : Bax to the Fussure, Developmental Cell, 20, (2), 2011, p142-143 Journal Article, 2011 TARA - Full Text DOI

Martin, S.J., Opening the cellular poison cabinet., Science, 330, 2010, p1330-1331 Journal Article, 2010 DOI

Clare Sheridan and Seamus J. Martin, Mitochondrial fission/fusion dynamics and apoptosis, Mitochondrion, 10, (6), 2010, p640-648 Journal Article, 2010 TARA - Full Text

Sheridan, C., Brumatti G., Elgendy, M., Brunet, M. and S. J. Martin., An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs., Oncogene, 29, 2010, p6428-6441 Journal Article, 2010 DOI

von Kampen O, Lipinski S, Till A, Martin S.J., Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P., The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling, The Journal of Biological Chemistry, 285, 2010, p19921-19926 Journal Article, 2010 DOI

Sheridan, C, Brumatti, G, Elgendy, M, Brunet, M, Martin, SJ, An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs, Oncogene, 29, (49), 2010, p6428-6441 Journal Article, 2010 DOI

Afonina, I., Cullen S. P and S. J. Martin., Cytotoxic and non cytotoxic roles of the CTL/NK proteases granzyme B. , Immunological Reviews, 235, (1), 2010, p105-116 Journal Article, 2010 DOI

Autret A, Martin SJ, Bcl-2 family proteins and mitochondrial fission/fusion dynamics., Cellular and molecular life sciences : CMLS, 67, (10), 2010, p1599-1606 Journal Article, 2010 DOI

Cullen SP, Brunet M, Martin SJ, Granzymes in cancer and immunity., Cell death and differentiation, 2010, p616-623 Journal Article, 2010 DOI

Carney, K., Latkowski, S., Maldonado-Basilio, R., Landais, P., Lennox, R., Bradley, A.L., Characterization of a multi-electrode bulk-SOA for low NF in-line amplification in passive optical networks, Prodeedings of 12th International Conference on Transparent Optical Network, 12th International Conference on Transparent Optical Networks, ICTON , Munich; Germany, 27 Jun - 1 Jul, 2010, ppart. no. 5549103 Conference Paper, 2010 DOI

Autret A, Martin SJ, Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis., Molecular cell, 36, (3), 2009, p355-63 Journal Article, 2009 TARA - Full Text DOI

Adrain C, Martin SJ, Apoptosis: calling time on apoptosome activity., Science signaling, 2, (91), 2009, ppe62 Journal Article, 2009 DOI

Alexander U. Lüthi, Sean P. Cullen, Edel A. McNeela, Patrick J. Duriez, Inna S. Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C. Taylor, Kristof Kersse, Peter Vandenabeele, Ed C. Lavelle, and Seamus J. Martin, Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases, Immunity, 31, (1), 2009, p84-98 Journal Article, 2009 TARA - Full Text DOI

Logue SE, Elgendy M, Martin SJ, Expression, purification and use of recombinant annexin V for the detection of apoptotic cells., Nature protocols, 4, (9), 2009, p1383-95 Journal Article, 2009 DOI

SP Cullen, SJ Martin, Caspase activation pathways: some recent progress, Cell Death and Differentiation, 16, (7), 2009, p935 - 938 Journal Article, 2009 URL

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G, Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes., Cell death and differentiation, 16, (8), 2009, p1093-1107 Journal Article, 2009 DOI TARA - Full Text

Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ, Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival., PloS one, 4, (3), 2009, pe5055 Journal Article, 2009 TARA - Full Text DOI

Cullen SP, Afonina IS, Donadini R, Lüthi AU, Medema JP, Bird PI, Martin SJ, Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing., The Journal of biological chemistry, 284, (8), 2009, p5137-5147 Journal Article, 2009 DOI

Logue SE, Martin SJ., Caspase activation cascades in apoptosis., Biochem Soc Trans. , 36 , (1), 2008, p1-9. Journal Article, 2008 URL

Sheridan C, Martin SJ, Commitment in apoptosis: slightly dead but mostly alive., Trends in cell biology, 18, (8), 2008, p353-357 Journal Article, 2008 DOI

Sheridan C, Delivani P, Cullen SP, Martin SJ, Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release., Molecular Cell, 31, (4), 2008, p570-85 Journal Article, 2008 DOI

Cullen SP, Lüthi AU, Martin SJ, Analysis of apoptosis in cell-free systems., Methods (San Diego, Calif.), 44, (3), 2008, p273-279 Journal Article, 2008 DOI

Martin SJ., Improvement by death in immunity., Cell Death Differ., 15, (2), 2008, p221-2 Journal Article, 2008 DOI URL

Sheridan C, Brumatti G, Martin SJ, Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim., The Journal of biological chemistry, 283, (32), 2008, p22128-35 Journal Article, 2008 DOI

Lüthi, A.U., Cullen, S.P., Martin, S.J., Chapter Seventeen Two-Dimensional Gel-Based Analysis of the Demolition Phase of Apoptosis, Methods in Enzymology , 442, 2008, p343-354 Journal Article, 2008

Taylor RC, Cullen SP, Martin SJ., Apoptosis: controlled demolition at the cellular level., Nature Reviews in Molecular Cell Biology, 9, (3), 2008, p231 - 241 Journal Article, 2008 URL DOI

Walsh JG, Cullen SP, Sheridan C, Lüthi AU, Gerner C, Martin SJ, Executioner caspase-3 and caspase-7 are functionally distinct proteases., Proceedings of the National Academy of Sciences of the United States of America, 105, (35), 2008, p12815-12819 Journal Article, 2008 DOI

Martin SJ., Getting the measure of apoptosis., Methods, 44, (3), 2008, p197-9 Journal Article, 2008 URL DOI

Cullen SP, Martin SJ, Mechanisms of granule-dependent killing., Cell death and differentiation, 15, (2), 2008, p251-62 Journal Article, 2008 DOI

Lüthi AU, Cullen SP, Martin SJ, Two-dimensional gel-based analysis of the demolition phase of apoptosis., Methods in enzymology, 442, 2008, p343-54 Journal Article, 2008 DOI

Brumatti G, Sheridan C, Martin SJ., Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells., Methods., 44, (3), 2008, p235-40 Journal Article, 2008 DOI URL

Cullen SP, Adrain C, Lüthi AU, Duriez PJ, Martin SJ, Human and murine granzyme B exhibit divergent substrate preferences., The Journal of Cell Biology, 176, (4), 2007, p435 - 444 Journal Article, 2007 DOI URL

Lüthi AU, Martin SJ., The CASBAH: a searchable database of caspase substrates., Cell Death and Differentiation, 14, (4), 2007, p641 - 650 Journal Article, 2007 URL DOI

Taylor RC, Brumatti G, Ito S, Hengartner MO, Derry WB, Martin SJ., Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease., J. Biol. Chem., 282, (20), 2007, p15011 - 15021 Journal Article, 2007 URL DOI

Adrain, C. and S. J. Martin , Double knockout blow for caspases. , Science, 311, 2006, p785 - 786 Journal Article, 2006 DOI URL

Adrain, C., Duriez, P. J., Brumatti, G., Delivani, P., and S. J. Martin , The cytotoxic lymphocyte protease, Granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics., J. Biol. Chem, 281, (12), 2006, p8118 - 8125 Journal Article, 2006 DOI URL

Adrain, C., Brumatti, G. and S. J, Martin, Apoptosomes: caspase activation platforms to die from., TRENDS IN BIOCHEMICAL SCIENCES, 31, (5), 2006, p243 - 247 Journal Article, 2006 URL DOI

Delivani P, Martin SJ., Mitochondrial membrane remodeling in apoptosis: an inside story., Cell Death Differ. , 13, (12), 2006, p2007-10 Journal Article, 2006 DOI URL

Delivani, P., Adrain, C., Taylor, RC., Duriez, P.J & S. J. Martin , Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics., MOLECULAR CELL, 21, (6), 2006, p761 - 773 Journal Article, 2006 URL DOI

Peter J. Delves, Seamus J. Martin, Dennis Burton & Ivan M. Roitt, ESSENTIAL IMMUNOLOGY, 11th Edition, UK, Blackwell Scientific, 2006 Book, 2006

Kroemer G, Martin SJ., Caspase-independent cell death., NATURE MEDICINE, 11, (7), 2005, p725 - 730 Journal Article, 2005 URL DOI

Adrain, C., Murphy, B. M., and S. J. Martin , Molecular Ordering of the Caspase Activation cascade Initiated by the CTL/NK Protease Granzyme B., J. Biol. Chem, 280, (6), 2005, p4663 - 4673 Journal Article, 2005 DOI URL

Taylor RC, Adrain C, Martin SJ, Proteases, proteasomes and apoptosis: breaking Ub is hard to do., CELL DEATH & DIFFERENTIATION, 12, (9), 2005, p1213 - 1217 Journal Article, 2005 DOI URL

Brunner T, Martin SJ, c-Myc - Where death and division collide, CELL CYCLE, 3, (4), 2004, p456 - 459 Journal Article, 2004 URL

Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ, Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (26), 2004, p26906 - 26914 Journal Article, 2004 TARA - Full Text DOI URL

Martin SJ, An Apollon vista of death and destruction, NATURE CELL BIOLOGY, 6, (9), 2004, p804 - 806 Journal Article, 2004 DOI URL

Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K, Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex , J. Biol. Chem, 279, (19), 2004, p19665 - 19682 Journal Article, 2004 DOI URL

Murphy BM, Creagh EM, Martin SJ, Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36916 - 36922 Journal Article, 2004 TARA - Full Text

Munarriz, E., Barcaroli, D., Stephanou, A., Townsend, P.A., Maisse, C., Terrinoni, A., Neale, M., Martin, S. J., Latchman, D. S., Knight, R.A., Melino, G. and De Laurenzi, V. , PIAS-1 Is a Check Point Regulator Which Affects Exit from G1 and G2 by Sumoylation of p73., Molecular and Cellular Biology, 24, (24), 2004, p10593 - 10610 Journal Article, 2004 URL DOI

Yang J.Y., Michod D., Walicki J., Murphy B.M., Kasibhatla S., Martin S. J., and Widmann C. , Partial Cleavage of RasGAP by Caspases Is Required for Cell Survival in Mild Stress Conditions., Molecular and Cellular Biology, 24, (23), 2004, p10425 - 10436 Journal Article, 2004 URL DOI

Adrain C, Creagh EM, Cullen SP, Martin SJ, Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, (35), 2004, p36923 - 36930 Journal Article, 2004 URL TARA - Full Text DOI

Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ, Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes, EMBO JOURNAL, 23, (10), 2004, p2134 - 2145 Journal Article, 2004

Adrain C, Creagh EM, Martin SJ, Defying death: showing Bcl-2 the way home, NATURE CELL BIOLOGY, 5, (1), 2003, p9 - 11 Journal Article, 2003

Glaser M, Collingridge DR, Aboagye EO, Bouchier-Hayes L, Hutchinson OC, Martin SJ, Price P, Brady F, Luthra SK, Iodine-124 labelled Annexin-V as a potential radiotracer to study apoptosis using positron emission tomography, APPLIED RADIATION AND ISOTOPES, 58, (1), 2003, p55 - 62 Journal Article, 2003

Creagh, E. M. and S. J. Martin., Cell stress-associated caspase activation: Intrinsically complex? , SCIENCE Stke, 175, 2003, p1 - 11 Journal Article, 2003

Murphy, B. M., O'Neill, A. J., Adrain, C., Watson, R. W. G. and S. J. Martin , The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c., THE JOURNAL OF EXPERIMENTAL MEDICINE, 197, 2003, p625 - 632 Journal Article, 2003

Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EO, In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope , BRITISH JOURNAL OF CANCER, 89, (7), 2003, p1327 - 1333 Journal Article, 2003

Hill MM, Adrain C, Martin SJ., Portrait of a killer: the mitochondrial apoptosome emerges from the shadows., Molecular Interventions , 3, 2003, p19 - 26 Journal Article, 2003

Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity., Immunological reviews, 193, 2003, p10-21 Journal Article, 2003

Creagh EM, Conroy H, Martin SJ, Caspase-activation pathways in apoptosis and immunity, IMMUNOLOGICAL REVIEWS, 193, (1), 2003, p10 - 21 Journal Article, 2003

Bouchier-Hayes, L & Martin SJ, CARD games in apoptosis and immunity, EMBO REPORTS, 3, (7), 2002, p616-621 Journal Article, 2002

van Loo G, Saelens X, van Gurp M, MacFarlane M, Martin SJ, Vandenabeele P, The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet., CELL DEATH AND DIFFERENTIATION, 9, 2002 Review, 2002

Martin, SJ, Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. , CELL, 109, 2002 Review, 2002

Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., The Journal of biological chemistry, 276, (47), 2001, p44069-77 Journal Article, 2001 DOI TARA - Full Text

Creagh EM, Martin SJ, Caspases: cellular demolition experts., BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p696 - 702 Journal Article, 2001

Adrain, C & Martin, SJ, The mitochondrial apoptosome: a killer unleashed by the cytochrome seas, TRENDS IN BIOCHEMICAL SCIENCES, 26, 2001 Review, 2001

Adrain C, Martin SJ, Search for Drosophila caspases bears fruit: STRICA enters the fray, CELL DEATH & DIFFERENTIATION, 8, (4), 2001, p319 - 323 Journal Article, 2001

Slee EA, Adrain C, Martin SJ, Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis., Journal of Biological Chemistry, 276, 2001, p7320 - 7326 Journal Article, 2001 TARA - Full Text

Adrain C, Creagh EM, Martin SJ, Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2, THE EMBO JOURNAL, 20, 2001, p6627 - 6636 Journal Article, 2001 TARA - Full Text

Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ., CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 2001, p44069 - 44077 Journal Article, 2001

Slee, E.A., Keogh, S. A., and Martin, S. J, Cleavage of BID During Cytotoxic Drug and UV Radiation-Induced Apoptosis Occurs Downstream of the Point of Bcl-2 Action and is Catalysed by Caspase-3: a Potential Feedback Loop for Amplification of Apoptosis-Associated Mitochondrial Cytochrome c Release, Cell Death & Differentiation, 7, 2000, p556 - 565 Journal Article, 2000

Eleouet, J.-F., Slee, E. A., Saurini, F., Castagné, N., Poncet, D., Garrido, C., Solary, E. and Martin, S. J, The viral nucleoprotein of the transmissible gastroenteritis coronavirus, TGEV, is cleaved by caspases -6 and -7 during TGEV-induced apoptosis: a potential host-defense mechanism for limiting virus replication during infection, The Journal of Virology , 74, 2000, p3975 - 3983 Journal Article, 2000

Keogh SA, Walczak H, Bouchier-Hayes L, Martin SJ, Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis, FEBS LETTERS, 471, 2000, p93 - 98 Journal Article, 2000

Slee, E.A., Harte, M.T., Kluck, R.M., Wolf, B.B., Casiano, C.A., Newmeyer, D.D., Wang, H.-G., Reed, J.C., Nicholson, D.W., Alnemri, E.S., Green D.R., and Martin S.J, Ordering the Cytochrome c-Initiated Caspase Cascade: Hierarchical Activation of Caspases -2, -3, -6, -7, -8 and -10 in a Caspase-9-Dependent Manner, THE JOURNAL OF CELL BIOLOGY, 144, 1999, p281 - 292 Journal Article, 1999

Adrain, C., Slee, E.A., Harte, M. T., and Martin S. J, Regulation of Apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region, The Journal of Biological Chemistry , 274, 1999, p20855 - 20860 Journal Article, 1999

Slee, E.A., Adrain, C. and Martin, S.J, Serial killers: Ordering caspase activation events in apoptosis, Cell Death and Differentiation, 6, 1999, p1067 - 1074 Journal Article, 1999

Slee, E.A., Adrain, C. and Martin, S.J, Serial killers: Ordering caspase activation events in apoptosis, Cell Death and Differentiation, 6, 1999, p1067 - 1074 Journal Article, 1999

Slee, E.A. and Martin, S.J, Regulation of caspase activation in apoptosis; implications for transformation and drug resistance, Cytotechnology, 27, 1999, p309 - 320 Journal Article, 1999

Martin, S. J, Apoptosis, In The Encyclopedia of Immunology 2nd edition, 1998, p220 - 227 Journal Article, 1998

Slee, E.A., Harte, M.T., and Martin, S.J, A duel to the death: activated caspases meet their substrates, Sepsis , 2, 1998, p21 - 29 Journal Article, 1998

Van Antwerp DJ, Martin SJ, Verma IM, Green DR, Inhibition of TNF-induced apoptosis by NF-kappa B, Trends in Cell Biology , 8, 1998, p107 - 111 Journal Article, 1998

Amarante-Mendes, GP, Finucane, DM, Martin, SJ, Cotter, TG, Salvesen, GS, Green, DR, Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death., Cell Death and Differentiation , 5, 1998, p298 - 306 Journal Article, 1998

Apoptosis in, editor(s)I. M. Roitt and P. J. Delves , In The Encyclopedia of Immunology 2nd edition, London, UK, Academic Press, 1998, pp220 - 227, [S. J Martin] Book Chapter, 1998

Kluck, R.M., Martin, S. J., Hoffman, B.M., Zhou, J.S., Green, D.R., and Newmeyer, D.D, cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. , EMBO Journal , 16, 1997, p4639 - 4649 Journal Article, 1997

Morphological features of apoptosis in, L.A. Herzenberg, D. M. Weir, L. Herzenberg, and C. Blackwell , In Weir's Handbook of Experimental Immunology 5th Edition , Blackwell Science, S. J Martin and Green, D. R, 1997, [S. J Martin ] Book Chapter, 1997

Di Stefano, L., Boland, F., A new phase extraction algorithm for phase profilometry, Machine Vision and Applications, 10, (4), 1997, p188-200. Journal Article, 1997 DOI URL

Tan, X., Martin, S. J., Green, D. R., and Wang, Jean Y. J, Degradation of retinoblastoma protein in TNF- and CD95-induced cell death, The Journal of Biological Chemistry , 272, 1997, p9613 - 9616 Journal Article, 1997

McGahon, A. J., Brown, D., Martin, S. J., Amarante-Mendes, G., Cotter, T. G., Cohen, G. M., and D. R., Green, Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death, Cell Death and Differentiation , 4, 1997, p95 - 104 Journal Article, 1997

Corbeil, J., and Martin, S. J, Apoptosis in HIV-1 induced pathogenesis, Trends in Experimental and Clinical Medicine, 7, 1997, p61 - 71 Journal Article, 1997

Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS,, Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases, The Journal of Neuroscience , 17, 1997, p6165 - 6178 Journal Article, 1997

Santana, P., Pena, L. A., Haimovitz-Friedman, A., Martin, S. J., Green, D. R., Cordon-Cardo, C., Schuchman, E. H., Fuks, Z., and Kolesnick, R, Acid sphingomyelinase-deficient mice and human lymphoblasts are defective in radiation-induced apoptosis, Cell, 86, 1996, p189 - 199 Journal Article, 1996

Green, D. R., and Martin, S. J, Cell Death and Differentiation The ICE/Ced-3 family proteases as the apoptot , Cell Death and Differentiation, 3, 1996, p339 - 340 Journal Article, 1996

Van Antwerp, D., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M, Suppression of TNF-a-induced apoptosis by NFkB, SCIENCE , 274, 1996, p787 - 789 Journal Article, 1996

Green, D. R., McGahon, A., and Martin S. J, Regulation of apoptosis by oncogenes , Journal of Cellular Biochemistry , 60, 1996, p33 - 38 Journal Article, 1996

Casiano, C. A., Martin, S. J., Green, D. R., and Tan E. M, The Journal of Experimental Medicine Proteolysis of a subset of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis, The Journal of Experimental Medicine, 184, 1996, p765 - 770 Journal Article, 1996

Meisenholder, G. W., Martin, S. J., Green, D. R., Nordberg, J., Babior, B. M., and Gottlieb, R. A, Events in apoptosis: acidification is downstream of protease activation and Bcl-2 protection, The Journal of Biological Chemistry , 271, 1996, p16260 - 16262 Journal Article, 1996

Martin, S. J., Finucane, D., Amarante-Mendes, G., O'Brien, G. A., and Green, D. R, Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. , The Journal of Biological Chemistry, 271, 1996, p28753 - 28756 Journal Article, 1996

Martin, S. J., Amarante-Mendes, G. P., Shi, L., Chuang, T.-H., Casiano, C. A., O'Brien, G. A., Fitzgerald, P., Tan, E. M., Bokoch, G. M., Greenberg, A. H., and Green, D. R., The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism. , The EMBO Journal , 15, 1996, p2407 - 2416 Journal Article, 1996

Martin, S. J., McGahon, A. J., Nishioka, W. K., La Face, D., Guo, X., Th'ng, J., Bradbury, E. M., and Green, D. R, p34cdc2 and apoptosis, Science, 269, 1995, p106 - 107 Journal Article, 1995

Martin, S. J. and D. R. Green , Critical Reviews in Oncology and Hematology , Apoptosis and Cancer: The failure of controls on cell death and cell survival, 18, 1995, p616 - 621 Journal Article, 1995

Martin, S. J., Reutelingsperger, C. P. M., McGahon, A. J., Rader, J., van Schie, R. C. C. A., LaFace, D., and Green, D. R, Redistribution of plasma membrane phospholipids is an early and widespread event during apoptosis: inhibition by overexpression of Bcl-2 and Abl, THE JOURNAL OF EXPERIMENTAL MEDICINE, 182, 1995, p1545 - 1556 Journal Article, 1995

Green, D. R., and Martin, S, The killer and the executioner: how apoptosis controls malignancy, The Current Opinion in Immunology, 7, 1995, p694 - 703 Journal Article, 1995

Martin, S. J., and Green, D. R, ICE/CED-3 protease (caspase) activation during apoptosis: death by a thousand cuts, Cell, 82, 1995, p349 - 352 Journal Article, 1995

McGahon, A. J., Nishioka, W. K., Martin, S. J., Cotter, T. G., and Green, T. G, Inhibition of Fas-induced apoptosis by Abl, The Journal of Biological Chemistry, 270, 1995, p22625 - 22631 Journal Article, 1995

Martin, S. J., Takayama, S., McGahon, A. J., Corbeil, J., Kolesnick, R. N., Reed, J. C., and Green, D. R, Inhibition of ceramide-induced apoptosis by Bcl-2, Cell Death and Differentiation, 2, 1995, p253 - 257 Journal Article, 1995

Brunner, T., Mogil, R., Mahboubi, A., La Face, D., Yoo, N., Echeverri, F., Martin, S. J., Force, R.W., Lynch, D. H., Ware, C., and Green, D. , Cell autonomous Fas (CD95)/Fas-ligand interaction involved in apoptosis of activated T cells, NATURE, 373, 1995, p441 - 444 Journal Article, 1995

Martin, S. J., Newmeyer, D. D., Mathias, S., Farschon, D., Wang, H.-G., Reed, J. C., Kolesnick, R. N., and Green, D. R, Cell-free reconstitution of Fas - UV radiation- and ceramide-induced apoptosis., The EMBO Journal, 14, 1995, p5191 - 5200 Journal Article, 1995

Gulbins, E., Bissonnette, R., Mahboubi, A., Martin, S. J., Brunner, T., Nishioka, W., Baier, G., Bitterlich-Baier, G., Byrd, C., Lang, F., Koelsnick, R., Altman, A., and Green, D. R, Fas-induced apoptosis is mediated by a ceramide-initiated Ras signalling pathway, IMMUNITY, 2, 1995, p341 - 351 Journal Article, 1995

Martin, S. J., O'Brien, G. A., McGahon, A. J., Nishioka, W. K., Saido, T., and Green, D, Proteolysis of fodrin (nonerythroid spectrin) during apoptosis, The Journal of Biological Chemistry...., 270, 1995, p6425 - 6428 Journal Article, 1995

Vyakarnam, A., Matear, P., and S. J. Martin and Wagstaff, M, Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells, Immunology, 86, 1995, p85 - 96 Journal Article, 1995

McGahon, A. J., Martin, S. J., Bissonnette, R. P., Mahboubi, A., Shi, Y., Mogil, R. J., Nishioka, W. K., and D. R. Green , The end of the (cell) line: Methods for the study of apoptosis in vitro , Methods in Cell Biology, 46, 1995, p153 - 185 Journal Article, 1995

Martin, S. J., Matear, P. M. and A. Vyakarnam, HIV-1 infection of human CD4+ T cells in vitro: Differential induction of apoptosis in these cells, Journal of Immunology , 152, 1994, p330 - 342 Journal Article, 1994

Martin , S. J., and Green, D. R, Apoptosis as a goal of cancer therapy, Current Opinion in Oncology, 6, 1994, p616 - 621 Journal Article, 1994

Martin S. J., Green, D. R., and T. G. Cotter , Dicing with death: dissecting the components of the apoptosis machinery, Trends in Biochemical Sciences, 19, 1994, p26 - 30 Journal Article, 1994

Martin, S. J., Vyakarnam, A., Cheingsong-Popov, R., Callow, D., Senior, J., Jones, K., Adams, S., Kingsman, A., Gotch, F., McMichael, A., Roitt, I. M., and J. N. Weber , Human HIV-seronegative volunteers immunized with recombinant p17/p24:Ty-virus like particles (p17/p24:Ty-VLP) develop p24-specific cellular and humoral immune responses, AIDS, 7, 1993, p1315 - 1323 Journal Article, 1993

Martin, S. J. , Programmed cell death and AIDS, SCIENCE, 262, 1993, p1355 - 1356 Journal Article, 1993

Martin, S. J, Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts, Immunology Letters, 35, 1993, p125 - 134 Journal Article, 1993

Martin, S. J, Apoptosis: Suicide, Execution or Murder? Conflicting evidence for protein and RNA synthesis requirements for apoptosis , Trends in Cell Biology, 3, 1993, p141 - 144 Journal Article, 1993

Martin, S. J. and T. G. Cotter , Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis, International Journal of Radiation Biology , 59, 1991, p1001 - 1016 Journal Article, 1991

Martin, S. J., Madzai, G., Strain, J. J., Cotter, T. G. and B. M. Hannigan, Clinical and Experimental.Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency, Immunology, 83, 1991, p338 - 343 Journal Article, 1991

Lennon, S. V., Martin, S. J. and T. G. Cotter , apoptosis in human tumour cell lines by widely diverging stimuli , Cell Proliferation, 24, 1991, p203 - 214 Journal Article, 1991

Martin, S. J., Bradley, J. G. M. and T. G. Cotter , HL-60 cells induced to differentiate towards neutrophils subsequently undergo a programmed cell death (apoptosis), Clinical and Experimental Immunology, 79, 1990, p448 - 453 Journal Article, 1990

Martin, S. J., Lennon, S. V., Bonham, A. M. and T. G. Cotter , Induction of apoptosis (programmed cell death) in human leukaemic HL-60 cells by inhibiton of RNA or protein synthesis, The Journal of Immunology, 145, 1990, p1859 - 1867 Journal Article, 1990

Cotter, T. G., Lennon, S. V., Glynn, J. and S. J. Martin, Cell death via apoptosis and its relationship to growth development and differentiation of both tumoral and normal cells, AntiCancer Research, 10, 1990, p1153 - 1160 Journal Article, 1990

Martin, S. J. and T. G. Cotter , Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells, Cell and Tissue Kinetics, 23, 1990, p545 - 559 Journal Article, 1990

Downing, C.P., Boland, F.M., Foley, J.B., Improved noise canceller performance by means of an adaptive arrangement , Proceedings of IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP , 3, 1989, pp2005-2008 Conference Paper, 1989 URL

Fahy, E., Martin, S. J. and Mulrooney, M, Interactions of roach and bream in an Irish reservoir, Archives of Hydrobiology, 114, 1988, p291 - 309 Journal Article, 1988

Martin, S. J. and Fahy, E, Food and growth of cyprinids in a Co. Dublin reservoir, Irish Naturalists Journal, 22, 1986, p107 - 110 Journal Article, 1986

Non-Peer-Reviewed Publications

Bouchier-Hayes L & Martin SJ, CARDINAL roles in apoptosis and NFkappaB activation., Vitamins and Hormones, 67, 2004, p133 - 147 Journal Article, 2004

Martin, S. J. , Caspase activation cascades in apoptosis., Chemtracts-Biochemistry and Molecular Biology, 16, 2003, p352 - 360 Journal Article, 2003

Caspase detection and analysis in, editor(s)Edited by D. Hughes and H. Mehmet , Cell Proliferation and Apoptosis , Oxford, UK, Bios Scientific Publishers, 2003, pp233 - 253, [Creagh, E. M., Adrain C., and S.J Martin] Book Chapter, 2003

Caspases: Structure, activation pathways and substrates in, X.-M. Yin and Z. Dong , In Essentials of Apoptosis-A guide for basic and Clinical Research, New Jersey,USA, Humana Press, 2003, pp3 - 12, [Murphy, B.M. and S.J Martin] Book Chapter, 2003

Caspase cascades in apoptosis in, editor(s)M. Los and H. Walczak , In Caspases-Their role in Cell Death and Cell Survival, New York, USA, Landes Bioscience/Kluwer Academic/Plenum Publishers, 2002, pp41 - 51, [S.J Martin] Book Chapter, 2002

Apoptosis and Cancer: an overview in, editor(s)S. J. Martin , In Apoptosis and Cancer , Austin, Texas, USA, S.J. Martin, 1997, pp1 - 8, [S.J. Martin] Book Chapter, 1997

Apoptosis: an introduction in, S. J. Martin , In Apoptosis and Cancer , Austin, Texas, USA, Landes Bioscience Publishers, 1997, pp9 - 24, [Martin, S. J] Book Chapter, 1997

Cell-free apoptosis in, editor(s)Martin, S. J., and D. R. Green , In Techniques in Apoptosis: A User's Guide , Portland Press, London, S.J Martin and D. R. Green, 1996, [S.J Martin] Book Chapter, 1996

Annexin V in, editor(s)Edited by T. G. Cotter and S. J. Martin , a specific probe for apoptotic cells. In Techniques in Apoptosis: A User's Guide , Portland Press, London, S. J Martin,C.P.M, Reutelingsperger and D. R. Green, 1996, [S. J Martin] Book Chapter, 1996

S. J Martin,Amarante-Mendes, G. P., and Green, D. R, Cytotoxic lymphocyte killing enters the ICE age, Adv. Exp. Med. Biol, 406, 1996, p29 - 37 Journal Article, 1996

Martin, S. J., and Green, D. R, HIV-induced apoptosis: a cytopathic effect of HIV or an important host-defense mechanism against viruses in general, Advances in Experimental Medicine and Biology , 374, 1995, p129 - 138 Journal Article, 1995

Apoptosis of human leukaemia cells: Induction, morphology, and molecular mechanisms in, editor(s)F. Cope and D. Tomei , Apoptosis II: the molecular basis of apoptosis in disease , Cold Spring Harbour, Cold Spring Harbour Laboratory Press, 1994, pp185 - 229, [Martin, S. J. and Cotter, T. G. ] Book Chapter, 1994

Assays of cellular activity in, editor(s)PJ Delves , Cellular Immunology LabFax , Oxford, UK, Bios Scientific Publishers, 1994, pp95 - 113, [McCulloch, J. and S. J. Martin ] Book Chapter, 1994

S.J. Martin. and T. G. Cotter , Specific loss of microtubules leads to programmed cell death , Biochemical Society Transactions , 18, 1990, p299 - 301 Journal Article, 1990

Lennon, S. V., Martin, S. J. and T. G. Cotter , Induction of apoptosis (programmed cell death) in tumor cell lines by widely diverging stimuli, Biochemical Society Transactions , 18, 1990, p343 - 345 Journal Article, 1990

S.J Martin,J.G Bradley, M. and T. G. Cotter , Identification and characterization of a low molecular mass cell surface differentiation antigen which is deposited extracellularly by differentiating U-937 cells. , Biochemical Society Transactions , 17, 1989, p418 - 419 Journal Article, 1989

Apoptosis as a mode of cell death in cultures of differentiating human leukemia cells in, editor(s)K. H. Chadwick, C. Seymour, and B. Barnhart , Transformation and radiation-induced cancer, Bristol, Adam Hilger, 1989, pp25 - 32, [Cotter, T. G. and Martin, S. J.] Book Chapter, 1989

Research Expertise


Molecular Control of Apoptosis (programmed cell death). Natural Killer Cell and CTL proteases (particularly granzyme B) and their mode of action. The role of caspases in inflammation. The role of Bcl-2 family proteins in chemoresistance in cancer. Cancer chemotherapy.


Antisera; Apoptosis; Apoptosis, molecular control; Autophagy; Biochemical Markers; Biological Markers; Biological Response Modifiers; Biology; Biomedical sciences; Caenorhabditis elegans; Cancer Biology; Cancer chemotherapeutic drugs- mode of action; Cancer chemotherapy; Cancer genetics and cell biology including metastasis; Cancer/Carcinogenesis; Caspase proteases; Cell and tissue maintenance, repair and ageing; Cell Communication; Cell Components; Cell cycle control; Cell Death; Cell Lines; Cellular, molecular and developmental immunology; Chemotherapeutic Agents; Chemotherapy; Chronic inflamation; Commercialisation of scientific research; Cytotoxic T cell Killing; DIABLO; Genetics; Genomic structure and function, molecular approaches to gene function; Granzymes; HIV virology and pathogenesis; Immune Enhancers; Immune system; Immune System Disorders; Immunity; Immunization; Immunogenetics; Immunology; Immunopathology; Immunotherapies for Cancer; Immunotherapy; In Vitro Testing, Trial Methods; Inflammation; INHIBITION; Innate immunology; Intra and intercellular signalling; Leukemia; Leukemias and lymphomas; Leukocyte Biology; Lymphocytes; Lymphoma; Medical Sciences, Research; Mitochondrial fission & fusion mechanisms; Molecular Biology; Molecular Cloning; Molecular Genetics; Molecular/Cellular Entities; Monoclonal Antibodies; OLIGOMERIZATION; Oncogenes, apoptosis and tumour development; Programmed Cell Death; PROTEIN; Proteins and Macromolecules; Proteomics; Screening of Drugs/Agents; SMAC; Tissue Culture; Toxicity and toxinology; Tumour immunology and immunotherapy; Vaccine; Virology and viral pathogenesis



Scientific Consultant, Clontech Inc. Palo Alto, USA. 1995-present

Appointed to the Board of the European working group on Apoptosis. 1994

Appointed to Editorial Board, Cell Death & Differentiation. 1996-present

Senior Editor, 'Cell Death & Differentiation', Nature Publishing Group 2000-present

Scientific Advisory Board, Association for International Cancer Research, UK. 2003-present

PhD examiner for The University of Dundee, University of Bristol, University of Leicester, Dublin Institute of Technology, NUI Maynooth.

Medical Research Council, UK Appointments & Tenure committees 2003, 2005

External Assessor for full professor & Personal Chair appointments, Scripps Institute, La Jolla, USA; University of Dundee, UK; University of Melbourne, Australia. 2004 & 2005

Awards and Honours

Institute of Biology of Ireland Gold Medal 1987

Human Frontier Science Program Organization Long-term Fellowship Award 1994

Wellcome Trust International Prize Travelling Fellowship Award. 1994

Wellcome Trust Senior Fellowship in Biomedical Science 1997

Elected to Fellowship of Trinity College Dublin. 2002

Science Foundation Ireland Fellow 2001

Scientific Advisory Board, Association of International Cancer Research, UK 2003

Short-listed for The Royal Irish Academy Boyle Medal 2002

Elected to the Board of Directors, International Cell Death Society, New York 2004

Elected to the Board of Directors of ECDO 2005

The BA Charles Darwin Award Lecture 2005

GlaxoSmithKline Award (Biochemical Society UK) 2005 2005


American Society for Biochemistry and Molecular Biology. 1999 – present

American Association for the Advancement of Science. 1998 – present

The Biochemical Society. 1987 – present