Professor Clive Williams
Fellow Emeritus, Fellows Emeritii
Publications and Further Research Outputs
Peer-Reviewed Publications
Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM, The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL"induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells., International journal of oncology, 49, (1), 2016, p74-88
Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M, Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells., Cancer biology & therapy, 17, (8), 2016, p849 - 858
Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells., Investigational new drugs, 34, (5), 2016, p663-76
Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15., Investigational new drugs, 34, (2), 2016, 159-167
Kelly PM, Bright SA, Fayne D, Pollock JK, Zisterer DM, Williams DC, Meegan MJ, Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles., Bioorganic & medicinal chemistry, 24, (18), 2016, p4075-99
Ryan GJ, Poynton FE, Elmes RB, Erby M, Williams DC, Quinn SJ, Gunnlaugsson T, Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(ii)-polypyridyl conjugates., Dalton transactions (Cambridge, England : 2003), 44, (37), 2015, p16332-44
O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54
Martínez-Calvo M, Orange KN, Elmes RB, la Cour Poulsen B, Williams DC, Gunnlaugsson T, Ru(ii)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents., Nanoscale, 8, (1), 2015, p563-74
Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505
Thorfinnur Gunnlaugsson, Miguel Martínez-Calvo, Kim Orange, Robert B. P. Elmes, Bjørn la Cour Poulsen and D. Clive Williams , Ru(II)-polypyridyl surface functionalised gold nano-particles as DNA targeting supramolecular structures and luminescent cellular imaging agents, Nanoscale, 2015
Spallarossa A, Caneva C, Caviglia M, Alfei S, Butini S, Campiani G, Gemma S, Brindisi M, Zisterer DM, Bright SA, Williams CD, Crespan E, Maga G, Sanna G, Delogu I, Collu G, Loddo R, Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents., European journal of medicinal chemistry, 102, 2015, p648-60
McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ, Synthesis and antiproliferative action of a novel series of maprotiline analogues., European journal of medicinal chemistry, 71, 2014, p333-53
Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells., Biochemical pharmacology, 87, (4), 2014, p611-24
Murphy S, Bright SA, Poynton FE, McCabe T, Kitchen JA, Veale EB, Williams DC, Gunnlaugsson T, Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases., Organic & biomolecular chemistry, 12, (34), 2014, p6610-23
Banerjee S, Bright SA, Smith JA, Burgeat J, Martinez-Calvo M, Williams DC, Kelly JM, Gunnlaugsson T, Supramolecular approach to enantioselective DNA recognition using enantiomerically resolved cationic 4-amino-1,8-naphthalimide-based Tröger's bases., The Journal of organic chemistry, 79, (19), 2014, p9272-83
Greene LM, Nolan DP, Regan-Komito D, Campiani G, Williams DC, Zisterer DM, Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells., International journal of oncology, 2013
Banerjee S, Kitchen JA, Bright SA, O'Brien JE, Williams DC, Kelly JM, Gunnlaugsson T, Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent., Chemical communications (Cambridge, England), 49, (76), 2013, p8522-8524
Bright SA, Brinkø A, Larsen MT, Sinning S, Williams DC, and Jensen HH. , . Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma, Bioorg Med Chem Lett. , 23, 2013, p1220 - 1224
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46
Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, Bifulco M, PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines., European journal of pharmacology, 2013
Elmes RB, Kitchen JA, Williams DC, Gunnlaugsson T, Pushing the limit: synthesis, photophysical and DNA binding studies of a NIR-emitting Ru(II)-polypyridyl probe with 'light switch' behaviour., Dalton transactions (Cambridge, England : 2003), 41, (22), 2012, p6607-10
Breen, JM, Clerac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, and Schmitt, W., Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages, Dalton Transactions, 41, (10), 2012, p2918 - 2926
Elmes RB, Erby M, Bright SA, Williams DC, Gunnlaugsson T, Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents., Chemical communications (Cambridge, England), 48, (20), 2012, p2588-90
Caboni L, Kinsella GK, Blanco F, Fayne D, Jagoe WN, Carr M, Williams DC, Meegan MJ, Lloyd DG, 'True' antiandrogens - selective non ligand-binding pocket disruptors of androgen receptor-coactivator interactions: Novel Tools for Prostate Cancer., Journal of Medicinal Chemistry, 55, (4), 2012, p1635 - 1644
Forde JC, Maginn EN, McNamara G, Martin LM, Campiani G, Williams DC, Zisterer D, McElligott AM, Lawler M, Lynch TH, Hollywood D, Marignol L, Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro., Cancer biology & therapy, 11, (4), 2011, p421-8
Maginn EN, Browne PV, Hayden P, Vandenberghe E, McDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM., PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells., British Journal of Cancer, 104, (2), 2011, p281 - 289
O'Boyle, N.M., Knox, A.J.S., Price, T.P., Williams, D.C., Zisterer, D.M., Lloyd, D.G., Meegan, M.J., Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90, Bioorganic & Medicinal Chemistry, 19, (20), 2011, p6055-6068
Yvonne M. McNamara, Suzanne M. Cloonan, Andrew J.S. Knox, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams, Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry, 19, (3), 2011, p1328 - 1348
Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T, Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents., Journal of the American Chemical Society, 133, (40), 2011, p15862 - 15865
Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, p686 - 688
Forde JC., Maginn EN., McNamara G., Martin LM., Campiani GC. , Williams DC, Zisterer D.M, McElligott AM., Lawler M, , Lynch TH, Hollywood D., Marignol L, Microtubule-Targeting-Compound PBOX-15 Radiosensitizes Cancer Cells In Vitro , Cancer Biology and Therapy, 11, (4), 2011, p6 - 13
Cloonan, S.M. and Williams, D.C. , The antidepressants maprotiline and fluoxetine induce Type-II autophagic cell death in drug resistant Burkitt's lymphoma, International Journal of Cancer, 128, 2011, p1712 - 1723
Nathwani,SM, Butler, S, Fayne,D, McGovern,NN, Sarkardi,B, Meegan,MJ, Lloyd,DG, Campiani,G, Lawler,M, Williams,DC, and Zisterer, DM, Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 66, (3), 2010, p585 - 596
Yang Y, Carta G, Peters MB, Price T, O'Boyle N, Knox AJ, Fayne D, Williams DC, Meegan MJ, Lloyd DG , 'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha, Molecular Informatics, 29, 2010, p421 - 430
S A Bright, A M McElligott, J W O'Connell, L O'Connor, P Carroll, G Campiani, M W Deininger, E Conneally, M Lawler, D C Williams, and D.M Zisterer, Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo , British Journal of Cancer, 102, 2010, p1474 - 1482
Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507
Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted á-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 18, 2010, p4009 - 4031
Onnis, Valeria; Kinsella, Gemma; Carta, Giorgio; Jagoe, William; Price, Trevor; Williams, Clive; Fayne, Darren; Lloyd, David, Virtual Screening for the identification of novel non-steroidal Glucocorticoid Modulators, Journal of Medicinal Chemistry, 53, 2010, p3065 - 3074
Nathwani, S-M., Butler, S., Meegan, M.J., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M., Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines., Cancer Chemotherapy and Pharmacology, 65, (2), 2010, p289-300
Sandra A. Bright, Giuseppe Campiani, Michael W. Deininger, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment , Biochemical Pharmacology, 80, 2010, p31 - 38
Cloonan SM, Dr0zgowska A, Fayne D and Williams DC, The antidepressants maprotiline and fluoxetine have potent antiproliferative effects against Burkitt's lymphoma independently of the norepinephrine and serotonin transporters, Leukemia and Lymphoma, 51, (3), 2010, p523 - 539
Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG, Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin., Journal of medicinal chemistry, 52, (8), 2009, p2177-80
Bright S.A., Greene, L.M., Greene, T.F., Campiani, G., Buitini, S., Brindisi, M., Lawler, M., Meegan, M.J., Williams, D.C. and Zisterer, D.M. , The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells, Biochemical Pharmacology, 77, (3), 2009, p310-321
McElligott, AM, Maginn, EN, Greene, LM, McGuckin, S, Hayat, A, Browne, PV, Butini, S, Campiani, G, Catherwood, MA, Vandenberghe, E, Williams, DC, Zisterer, DM, Lawler, M, The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia., Cancer Research, 69, (21), 2009, p8366 - 8375
Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888
Bane, F.T., Pennington, S.R., Campiani, G., Williams, D.C., Zisterer, D.M. & Mc Gee, M.M. , The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells., Journal of Pharmacology and Experimental Therapeutics, 329, 2009, p38-47
Greene, LM, Campiani, GC, Lawler, M, Williams, DC and Zisterer, DM, BubR1 is Required for a Sustained Mitotic Spindle checkpoint arrest in Human Cancer cells treated with a tubulin-targetting pyrrolo-1,5-benzoxazepine, Molecular Pharmacology, 73, (2), 2008, p419 - 430
Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y., A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin., Journal of Molecular Medicine, 86, (4), 2008, p457-469
Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM., STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells., Journal of Pharmacology and Experimental Therapeutics, 321, (1), 2007, p288-297
Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG., Target specific virtual screening: optimization of an estrogen receptor screening platform., Journal of Medicinal Chemistry, 50, (22), 2007, p5301-5310
McGrath, LB, Onnis, V, Campiani, G, Williams, DC, Zisterer, DM and McGee, MM, Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn(2+)-dependent acidic endonuclease activity., Apoptosis, 11, (9), 2006, p1473 - 1487
Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70
McGee, MM, Gemma, S, Rammunno, A, Zisterer,DM, Fatterusso, C, Catalanotti, B, Butini, S, Fiorini,I, Pisano, C, Cucco, C, Novellino, E, Nacci, V, Williams, DC and Campiani, G, Pyrolo [1,5] benzoxathiazepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target., Journal of Medicinal Chemistry, 48, (13), 2005, p4367 - 4377
Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363
Magnani F, Tate CG, Wynne S, Williams DC , and Haase,J., Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin, J. Biol.Chem., 279, 2004, p38770 - 38778
Lloyd DG, Hughes RB, Zisterer DM, Williams DC, Fattorusso C, Catalanotti B, Campiani G, Meegan MJ., Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor, Journal of Medicinal Chemistry, 47, (23), 2004, p5612 - 5615
M. M. Mc Gee, L. M. Greene, S. Ledwidge, G. Campiani, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL, The Journal of pharmacology and experimental therapeutics, 310, (3), 2004, p1084-1095
Lloyd, D.G., Hughes, R.B., Zisterer, D.M., Williams, D.C., Fattorusso, C., Catalanotti, B. Campiani, G.C., and Meegan, M.J., Benzoxepin-derived estrogen receptor modulators - a novel molecular scaffold for the estrogen receptor, J Med Chem, 47, 2004, p5612 - 5615
Rogers, A, Schmuck, G, Scholz, G, and Williams D.C., c-fos mRNA expression in rat cortical neurons during glutamate-mediated excitotoxicity, Toxicol. Sci., 82, 2004, p562 - 569
Tate, C.G., Haase, J., Baker, C.M., Boorsma, M., Magnani, F., Vallis, Y., and Williams, D.C., Comparison of seven different protein expression systems for the production of the serotonin transporter, Biochim. Biophys. Acta., 1610, 2003, p141 - 153
M. M. Mc Gee, G. Campiani, A. Ramunno, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells, The Journal of Biological Chemistry, 277, (21), 2002, p18383-18389
Campiani, G., Ramuno, A., Fiorini, I., Nacci, V., Morelli, E., Novellino, E., Menninni, T., Zisterer, D.M., Williams, D.C. , Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral-type benzodiazepine receptors (PBR)., Journal Medicinal Chemistry, 45, (19), 2002, p4276 - 4281
ZISTERER, DM, MCGEE, MM, CAMPIANI, G, RAMUNNO, A, FATTORUSSO, C, NACCI, V, LAWLER, M, WILLIAMS, DC, PYRROLO-1,5-BENZOXAZEPINES: A NEW CLASS OF APOPTOTIC AGENTS, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p704 - 706
MEEGAN, MJ, HUGHES, RB, LLOYD, DG, WILLIAMS, DC, ZISTERER, DM, FLEXIBLE ESTROGEN RECEPTOR MODULATORS: DESIGN, SYNTHESIS, AND ANTAGONISTIC EFFECTS IN HUMAN MCF-7 BREAST CANCER CELLS, JOURNAL OF MEDICINAL CHEMISTRY, 44, 2001, p1072 - 1084
SCANLON, SM, WILLIAMS, DC, SCHLOSS, P, MEMBRANE CHOLESTEROL MODULATES SEROTONIN TRANSPORTER ACTIVITY, BIOCHEMISTRY, 40, 2001, p10507 - 10513
MEEGAN, MJ, HUGHES, RB, LLOYD, DG, WILLIAMS, DC, ZISTERER, DM, ETHYL SIDE-CHAIN MODIFICATIONS IN NOVEL FLEXIBLE ANTIESTROGENS - DESIGN, SYNTHESIS AND BIOLOGICAL EFFICACY IN ASSAY AGAINST THE MCF-7 BREAST TUMOR CELL LINE, ANTI-CANCER DRUG DESIGN, 16, 2001, p57 - 69
D. M. Zisterer, M. M. McGee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler and D. C. Williams, Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents, Biochemical Society transactions, 29, (6), 2001, p704-706
M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl, The Journal of Pharmacology and Experimental Therapeutics, 296, (1), 2001, p31-40
MC GEE, MM, CAMPIANI, G, RAMUNNO, A, FATTORUSSO, C, NACCI, V, LAWLER, M, WILLIAMS, DC, ZISTERER, DM, PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS IN CHRONIC MYELOGENOUS LEUKEMIA (CML) CELLS BY BYPASSING THE APOPTOTIC SUPPRESSOR BCR-ABL, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 296, 2001, p31 - 40
Williams. D.C., and Haase, J. ( eds), Neurotransmitter Transporters: Molecular mechanism and regulation, Biochem. Soc. Trans., 29, 2001, 707 - 750
Meegan, M., Hughes, R., Lloyd, D.G., Zisterer, D.M. & Williams, D.C. , Flexible estrogen receptor modulators: design, synthesis and antagonistic effects in human MCF-7 breast cancer cells. , Journal Medicinal Chemistry, 44, (7), 2001, p1072 - 1084
M. Marangolo, M. M. McGee, K. F. Tipton, D. C. Williams and D. M. Zisterer, Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B, Neurotox Research, 3, (4), 2001, p397-409
HAASE, J, KILLIAN, AM, MAGNANI, F, WILLIAMS, C, REGULATION OF THE SEROTONIN TRANSPORTER BY INTERACTING PROTEINS, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p722 - 728
ZISTERER, DM, CAMPIANI, G, NACCI, V, WILLIAMS, DC, PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS IN HL-60, JURKAT, AND HUT-78 CELLS: A NEW CLASS OF APOPTOTIC AGENTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 293, 2000, p48 - 59
Zisterer, D.M., Campiani., Nacci, V. & Williams, D.C. , Pyrrolobenzoxazepines induce apoptosis in HL-60, Jurkat and Hut-78 cells: A new class of apoptotic agents., Journal Pharmacology and Experimental Therapeutics, 293, (1), 2000, p48 - 59
Zisterer D.M., Campiani, G., Garafalo, A., Nacci, V. and Williams, D.C. , Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site, Biochemical Pharmacology, 55, (4), 1998, p397 - 403
ZISTERER, DM, HANCE, N, CAMPIANI, G, GAROFALO, A, NACCI, V, WILLIAMS, DC, ANTIPROLIFERATIVE ACTION OF PYRROLOBENZOXAZEPINE DERIVATIVES IN CULTURED CELLS: ABSENCE OF CORRELATION WITH BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE, BIOCHEMICAL PHARMACOLOGY, 55, 1998, p397 - 403
SCHLOSS, P, WILLIAMS, DC, THE SEROTONIN TRANSPORTER: A PRIMARY TARGET FOR ANTIDEPRESSANT DRUGS, JOURNAL OF PSYCHOPHARMACOLOGY, 12, 1998, p115 - 121
Zisterer, D.M. and Williams, D.C., Peripheral-type benzodiazepine receptors, General Pharmacology, 29, (3), 1997, p305 - 314
ZISTERER, DM, MOYNAGH, PN, WILLIAMS, DC, HEXACHLOROCYCLOHEXANES INHIBIT STEROIDOGENESIS IN Y1 CELLS - ABSENCE OF CORRELATION WITH BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE, BIOCHEMICAL PHARMACOLOGY, 51, 1997, p1303 - 1308
WOODS, MJ, ZISTERER, DM, WILLIAMS, DC, TWO CELLULAR AND SUBCELLULAR LOCATIONS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR IN RAT LIVER, BIOCHEMICAL PHARMACOLOGY, 51, 1997, p1283 - 1292
ZISTERER, DM, WILLIAMS, DC, CALMIDAZOLIUM AND OTHER IMIDAZOLE COMPOUNDS AFFECT STEROIDOGENESIS IN Y1 CELLS: LACK OF INVOLVEMENT OF THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 60, 1997, p189 - 195
D. M. Zisterer, P. N. Moynagh and D. C. Williams, Hexachlorocyclohexanes inhibit steroidogenesis in Y1 cells. Absence of correlation with binding to the peripheral-type benzodiazepine binding site, Biochemical Pharmacology, 51, (10), 1996, p1303-1308
DUNICAN, DJ, GRIFFITHS, R, WILLIAMS, DC, ONEILL, LAJ, ENDOTHELIN-1 INCREASES ARACHIDONIC ACID RELEASE IN C6 GLIOMA CELLS THROUGH A POTASSIUM-MODULATED INFLUX OF CALCIUM, JOURNAL OF NEUROCHEMISTRY, 67, 1996, p830 - 837
Woods MJ, Zisterer DM, Williams DC. , Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. , Biochemical Pharmacology, 51, (10), 1996, p1283 - 1292
WOODS, MJ, WILLIAMS, DC, MULTIPLE FORMS AND LOCATIONS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, BIOCHEMICAL PHARMACOLOGY, 52, 1996, p1805 - 1814
CAMPIANI, G, NACCI, V, FIORINI, I, DEFILIPPIS, MP, GAROFALO, A, CIANI, SM, GRECO, G, NOVELLINO, E, WILLIAMS, DC, ZISTERER, DM, WOODS, MJ, MIHAI, C, MANZONI, C, MENNINI, T, SYNTHESIS, BIOLOGICAL ACTIVITY, AND SARS OF PYRROLOBENZOXAZEPINE DERIVATIVES, A NEW CLASS OF SPECIFIC ''PERIPHERAL-TYPE'' BENZODIAZEPINE RECEPTOR LIGANDS, JOURNAL OF MEDICINAL CHEMISTRY, 39, 1996, p3435 - 3450
Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Ciani SM, Greco G, Novellino E, Williams DC, Zisterer DM, Woods MJ, Mihai C, Manzoni C, Mennini T. , Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands., Journal of Medicinal Chemistry, 39, (18), 1996, p3435 - 3450
DUNICAN, DJ, GRIFFITHS, R, ONEILL, LAJ, WILLIAMS, DC, DEPOLARIZING LEVELS OF KCI INHIBIT ENDOTHELIN-1-MEDIATED RELEASE OF ARACHIDONIC-ACID IN RAT C6 GLIOMA-CELLS, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS285 - S285
ZISTERER, DM, SUNOL, C, MOYNAGH, PN, WILLIAMS, DC, RODRIGUEZFARRE, E, PK-11195 REDUCES THE BRAIN AVAILABILITY OF LINDANE IN RATS AND THE CONVULSIONS INDUCED BY THIS NEUROTOXIC AGENT, LIFE SCIENCES, 57, 1995, p2359 - 2364
TARRANT, HM, WILLIAMS, DC, DITHIOTHREITHOL PROMOTES A HIGHER AFFINITY STATE OF THE SEROTONIN TRANSPORTER FOR THE TRICYCLIC ANTIDEPRESSANT, IMIPRAMINE, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS41 - S41
ZISTERER, DM, WILLIAMS, DC, IDENTIFICATION BF NOVEL LIGANDS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS371 - S371
D. M. Zisterer, C. Sunol, P. N. Moynagh, D. C. Williams and E. Rodriguez-Farre, PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent, Life Sciences, 57, (25), 1995, p2359-2364
TARRANT, HM, WILLIAMS, DC, RECONSTITUTION OF THE RAT-BRAIN SEROTONIN TRANSPORTER, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS40 - S40
WORRALL, DM, SODIUM ION-DEPENDENT TRANSPORTERS FOR NEUROTRANSMITTERS - A REVIEW OF RECENT DEVELOPMENTS, by WILLIAMS, DC , BIOCHEMICAL JOURNAL, 297, 1994, p425 - 436
MOYNAGH, PN, SCHOUSBOE, A, WILLIAMS, DC, THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR IS PRESENT IN ASTROCYTES BUT IS NOT A PRIMARY SITE OF ACTION FOR CONVULSANTS/ANTICONVULSANTS, JOURNAL OF NEUROCHEMISTRY, 62, 1994, p673 - 679
ATTERWILL, CK, BRUININK, A, DREJER, J, DUARTE, E, ABDULLA, EM, MEREDITH, C, NICOTERA, P, REGAN, C, RODRIGUEZFARRE, E, SIMPSON, MG, SMITH, R, VERONESI, B, VIJVERBERG, H, WALUM, E, WILLIAMS, DC, IN-VITRO NEUROTOXICITY TESTING - THE REPORT AND RECOMMENDATIONS OF ECVAM WORKSHOP-3, ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 22, 1994, p350 - 362
MOYNAGH, PN, WILLIAMS, DC, ONEILL, LAJ, ACTIVATION OF NF-KAPPA-B AND INDUCTION OF VASCULAR CELL-ADHESION MOLECULE-1 AND INTRACELLULAR ADHESION MOLECULE-1 EXPRESSION IN HUMAN GLIAL-CELLS BY IL-1 - MODULATION BY ANTIOXIDANTS, JOURNAL OF IMMUNOLOGY, 153, 1994, p2681 - 2690
MOYNAGH, PN, INTERLEUKIN-1 ACTIVATES TRANSCRIPTION FACTOR NF-KAPPA-B IN GLIAL-CELLS, 1993, -
MOYNAGH, PN, ONEILL, LAJ, WILLIAMS, DC, INTERLEUKIN-1 AND PHORBOL-MYRISTATE ACETATE MODULATE THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR IN LYMPHOCYTES AND GLIAL-CELLS, BIOCHEMICAL PHARMACOLOGY, 46, 1993, p821 - 827
Zisterer DM, Gorman AM, Williams DC, Murphy MP. , The effects of the peripheral-type benzodiazepine acceptor ligands, Ro5-4864 and PK 11195, on mitochondrial respiration. , Methods and Findings in Experimental and Clinical Pharmacology, 14, (2), 1992, p85 - 90
MOYNAGH, PN, WILLIAMS, DC, STABILIZATION OF THE PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTOR BY SPECIFIC PHOSPHOLIPIDS, BIOCHEMICAL PHARMACOLOGY, 43, 1992, p1939 - 1945
WILLIAMS, DC, PHILLIPS, OM, PROBING THE PLATELET PLASMA-MEMBRANE 5-HYDROXYTRYPTAMINE TRANSPORTER, BIOCHEMICAL SOCIETY TRANSACTIONS, 19, 1991, p112 - 115
REGAN, CM, LARSSON, OM, MARTIN, ML, SCHOUSBOE, A, WILLIAMS, DC, INVITRO SCREENING FOR ANTICONVULSANT-INDUCED TERATOGENESIS - STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE BARBITURATE AND BRANCHED-CHAIN CARBOXYLIC-ACID CLASSES, TOXICOLOGY IN VITRO, 5, 1991, p77 - 82
MOYNAGH, PN, BAILEY, CJ, BOYCE, SJ, WILLIAMS, DC, IMMUNOLOGICAL STUDIES ON THE RAT PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTOR, BIOCHEMICAL JOURNAL, 275, 1991, p419 - 425
REGAN, CM, GORMAN, AMC, LARSSON, OM, MAGUIRE, C, MARTIN, ML, SCHOUSBOE, A, WILLIAMS, DC, INVITRO SCREENING FOR ANTICONVULSANT-INDUCED TERATOGENESIS IN NEURAL PRIMARY CULTURES AND CELL-LINES, INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 8, 1990, p143 - 150
RONAYNE, L, MCINERNEY, M, PHILLIPS, OM, REGAN, CM, WILLIAMS, DC, A MONOCLONAL ANTI-IMIPRAMINE ANTIBODY WITH ANTIDEPRESSANT BINDING-PROPERTIES SIMILAR TO THE MUSCARINIC RECEPTOR, BIOCHEMICAL PHARMACOLOGY, 39, 1990, p507 - 511
ORIORDAN, C, PHILLIPS, OM, WILLIAMS, DC, 2 AFFINITY STATES FOR [H-3] IMIPRAMINE BINDING TO THE HUMAN PLATELET 5-HYDROXYTRYPTAMINE CARRIER - AN EXPLANATION FOR THE ALLOSTERIC INTERACTION BETWEEN 5-HYDROXYTRYPTAMINE AND IMIPRAMINE, JOURNAL OF NEUROCHEMISTRY, 54, 1990, p1275 - 1280
OBEIRNE, GB, WOODS, MJ, WILLIAMS, DC, 2 SUBCELLULAR LOCATIONS FOR PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTORS IN RAT-LIVER, EUROPEAN JOURNAL OF BIOCHEMISTRY, 188, 1990, p131 - 138
BARRY, S, PHILLIPS, OM, WILLIAMS, DC, DINAN, TG, PLATELET 5-HT UPTAKE IN POSTSTROKE DEPRESSION, ACTA PSYCHIATRICA SCANDINAVICA, 82, 1990, 88 - 89
GORMAN, AMC, OBEIRNE, GB, REGAN, CM, WILLIAMS, DC, ANTIPROLIFERATIVE ACTION OF BENZODIAZEPINES IN CULTURED BRAIN-CELLS IS NOT MEDIATED THROUGH THE PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTOR, JOURNAL OF NEUROCHEMISTRY, 53, 1989, p849 - 855
SMYTHE, E, WILLIAMS, DC, A SIMPLE RAPID PURIFICATION SCHEME FOR HYDROXYMETHYLBILANE SYNTHASE FROM HUMAN-ERYTHROCYTES, BIOCHEMICAL JOURNAL, 251, 1988, p237 - 241
SMYTHE, E, WILLIAMS, DC, RAT-LIVER UROPORPHYRINOGEN-III SYNTHASE HAS SIMILAR PROPERTIES TO THE ENZYME FROM EUGLENA-GRACILIS, INCLUDING ABSENCE OF A REQUIREMENT FOR A REVERSIBLY BOUND COFACTOR FOR ACTIVITY, BIOCHEMICAL JOURNAL, 253, 1988, p275 - 279
OBEIRNE, GB, WILLIAMS, DC, THE SUBCELLULAR LOCATION IN RAT-KIDNEY OF THE PERIPHERAL BENZODIAZEPINE ACCEPTOR, EUROPEAN JOURNAL OF BIOCHEMISTRY, 175, 1988, p413 - 421
ONEILL, C, WILLIAMS, DC, THE EFFECT OF TRITON X-100 ON BOVINE BRAIN SYNAPTIC-MEMBRANES, NEUROCHEMICAL RESEARCH, 13, 1988, p871 - 877
PHILLIPS, OM, WOOD, KM, WILLIAMS, DC, KINETICS OF THE INTERACTION OF SERTRALINE WITH THE HUMAN-PLATELET PLASMA-MEMBRANE 5-HYDROXYTRYPTAMINE CARRIER, EUROPEAN JOURNAL OF PHARMACOLOGY, 146, 1988, p299 - 306
WILLIAMS, DC, OBEIRNE, GB, HIGH-AFFINITY PERIPHERAL-TYPE BENZODIAZEPINE-BINDING SITES, BIOCHEMICAL SOCIETY TRANSACTIONS, 15, 1987, p220 - 220
OCALLAGHAN, AM, PHILLIPS, OM, WILLIAMS, DC, ANTISERA RAISED AGAINST THE DRUG IMIPRAMINE, JOURNAL OF NEUROCHEMISTRY, 49, 1987, p1091 - 1095
WILLIAMS, DC, POSSIBLE ARTIFACTS IN IMPIRAMINE BINDING ASSAYS - RESPONSE, 1985, -
O'Beirne, G. B. & Williams D.C., Binding of Benzodiazepines to Blood Platelets from Various Species, Biochem. Pharmacol., 33, 1984, p1563 - 1571
WILLIAMS, DC, CHARACTERIZATION OF THE MULTIPLE FORMS OF HYDROXYMETHYLBILANE SYNTHASE FROM RAT SPLEEN, BIOCHEMICAL JOURNAL, 217, 1984, p675 - 683
PHILLIPS, OM, WILLIAMS, DC, MULTIPLE AFFINITY STATES FOR [H-3]IMIPRAMINE BINDING-SITES ON HUMAN-PLATELET MEMBRANES, EUROPEAN JOURNAL OF PHARMACOLOGY, 100, 1984, 247 - 248
PHILLIPS, OM, WOOD, KM, WILLIAMS, DC, BINDING OF [H-3]IMIPRAMINE TO HUMAN-PLATELET MEMBRANES WITH COMPENSATION FOR SATURABLE BINDING TO FILTERS AND ITS IMPLICATION FOR BINDING-STUDIES WITH BRAIN MEMBRANES, JOURNAL OF NEUROCHEMISTRY, 43, 1984, p479 - 486
Williams, D.C., Characterisation of the Multiple Forms of Hydroxymethylbilane Synthase From Rat Spleen, Biochem. J., 217, 1984, p675 - 683
GRIFFITHS, R, WILLIAMS, DC, ONEILL, C, DEWHURST, IC, EKUWEM, CE, SINCLAIR, CD, SYNERGISTIC INHIBITION OF [H-3]MUSCIMOL BINDING TO CALF-BRAIN SYNAPTIC-MEMBRANES IN THE PRESENCE OF L-HOMOCYSTEINE AND PYRIDOXAL 5'-PHOSPHATE - A POSSIBLE MECHANISM FOR HOMOCYSTEINE-INDUCED SEIZURES, EUROPEAN JOURNAL OF BIOCHEMISTRY, 137, 1984, p467 - 478
Phillips, O.M. & Williams, D.C., Multiple Affinity States for [3H]-Imipramine Binding Sites on Human Platelet Membranes, Eur. J. Pharmacol., 100, 1984, p247 - 248
OBEIRNE, GB, BINDING OF BENZODIAZEPINES TO BLOOD-PLATELETS FROM VARIOUS SPECIES, 1984, -
Phillips, O.M., Wood, K.M. & Williams, D.C., Binding of [3H]-Imipramine to Human Platelet Membranes with Compensation for Saturable Binding to Filters and the Implication for Binding Studies with Brain Membranes, J. Neurochem., 43, 1984, p479 - 485
Griffiths, R., Williams, D.C., O'Neill, C., Dewhurst, I.C., Ekuwem, C.E. & Sinclair, C.D., Synergistic Inhibition of [3H]Muscimol Binding to Calf Brain Synaptic Membranes in the Presence of L-Homocysteine and Pyridoxal 5'-Phosphate. A Possible Mechanism for Homocysteine-Induced Seizures, Eur. J. Biochem., 1983, p467 - 478
Battersby, A.R., Buckley, D.G., Johnson, D.W., Mander, L.N., McDonald, E. & Williams, D.C., Biosynthesis of Porphyrins and Related Macrocycles. Part 15. Chemical and Enzymic Formation of Uroporphyrinogen Isomers From Unrearranged Aminoethylpyrromethane : Separation of Isomeric Coproporphyrin Esters, J. Chem. Soc. Perkin I., 1981, p2279 - 2785
Williams, D.C., Morgan, G.S., McDonald, E. & Battersby, A.R., Purification of Porphobilinogen Deaminase from Euglena Gracilis and Studies of its Kinetics, Biochem. J., 193, 1981, p301 - 310
Battersby, A.R., McDonald, E., Hollenstein, R., Ihara, M., Satoh, F. & Williams D.C., Biosynthesis of Porphyrinogens and Related Macrocycles.Vitamin B-12. Biochemical Derivation of Cobyrinic Acid From Uroporphyrinogen III. Studies With The Corresponding Ring-C-Methyl Heptacarboxylic Porphyrinogen and Proof of Seven Intact Methyl Transfers, J. Chem. Soc. Chem. Perkin I., 1977, p166 - 178
Battersby, A.R., Buckley, D.G., McDonald, E. & Williams, D.C., Enzymic Formation of the Type III Porphyrin Macrocycle from Unrearranged AP.AP Pyrromethane, J. Chem. Soc. Chem. Commun., 1977, p115 - 117
Ahrens, E.H., Williams, D.C. & Battersby, A.R., Biosynthesis of Porphyrins and Related Macrocycles. Part 11. Studies of Biosynthesis of the Phytyl Chain of Chlorophyll A Using Carbon-13, J. Chem. Soc. Chem. Perkin I., 1977, p2540 - 2545
Battersby, A.R., McDonald, E., Williams, D.C. & Wurziger, H.K.W., Biosynthesis of the Natural (Type III) Porphyrins. Proof that Rearrangement Occurs after Head-to-tail Bilane Formation, J. Chem. Soc. Chem. Commun., 1977, p113 - 115
Battersby, A.R., McDonald, E., Morris, H.R., Thompson, M., Williams, D.C., Bykhovsky, V.Y., Zaitseva, N.I. & Bukin, V. N., Biosynthesis of Vitamin B-12. Structural Studies On the Corriphyrins from Propionibacterium Shermanii and Link with Sirodihydrochlorin, Tetrahedron Letters, 25, 1977, p2217 - 2220
Battersby, A.R., Johnson, D.W., McDonald, E. & Williams, D.C., Mechanistic Study of the Enzymic Incorporation of Unrearranged AP.AP Pyrromethane into Uroporphyrinogen III, J. Chem. Soc. Chem. Commun., 1977, p117 - 118
Battersby, A.R., Hollenstein, R., McDonald, E. & Williams, D.C., Biosynthesis of Vitamin B-12. Evidence from Double-labelling Studies (13-CD3) for the Intact Incorporation of Seven Methyl Groups, J. Chem. Soc. Chem. Commun., 1976, p543 - 544
Williams, D.C. & Jones, J.G., Dissociation and Catalysis in Yeast Hexokinase A, Biochem. J., 155, 1976, p661 - 667
Bryce, C.F.A., Williams, D.C., John, R.A. & Fasella, P., Anomalous Kinetics of Coupled Aspartate Aminotransferase and Malate Dehydrogenase Evidence for Compartmentation of Oxaloacetate, Biochem. J, 1976, p571 - 577
Battersby, A.R., Sheldrake, P.W., Staunton, J. & Williams, D.C., Studies on Enzyme-mediated Reactions Part VII : Stereo Specific Syntheses of Tritium Labelled (2R)- and (2S)- Dopamine. Stereochemical Course of Hydroxylation of Dopamine by Dopamine-Beta-Hydroxylase, J. Chem. Soc. Perkin I., 1976, p1056 - 1062
Battersby, A.R., Ihara, M., McDonald, E., Satoh, F. & Williams, D.C., Biosynthesis of Vitamin B-12: Derivation of Cobyrinic Acid From Uroporphyrinogen III, J. Chem. Soc. Chem. Commun., 1975, p436 - 437
Battersby, A.R., Sheldrake, P.W., Staunton, J. & Williams, D.C., Stereochemical Course of Hydroxylation of Dopamine by Dopamine-Beta-Hydroxylase, J. Chem. Soc. Chem. Commun., 1974, p566 - 567
Non-Peer-Reviewed Publications
Haase, J., Killian, A-M., Magnani, F., and Williams, D.C., Regulation of the serotonin transporter by interacting proteins, Biochem. Soc. Trans., 29, 2001, p722 - 728
Zisterer, D.M., McGee, M.M., Campiani.G.C., Ramunno, A., Fattorusso, C., Nacci, V., Lawler,M., and Williams, D.C., Pyrrolo-1,5, benzoxazepines: a new class of apoptotic agents, Biochem. Soc. Trans., 29, 2001, 704 - 706
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., Zisterer, D.M., Campiani, G.C., Fattorusso, C., and Catalanotti, B., Novel conformationally restrained estrogen receptor modulators - design, synthesis, and antagonistic effects in human breast cancer cells, Proceedings of the Molecular Graphics and Modelling Society Symposium on Structure-Based Drug Design, St. Catherine's College, University of Oxford, 2000
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 23rd Annual Pharmacy Joint Research Seminar, Trinity College Dublin, 2000
Griffiths, R., Grieve, A., Scollon, J., Scott, M., Williams., D.C. and Meredith, C., Preliminary validation of an in vitro test for assessment of excitotoxicity by measurement of early c-fos mRNA levels, J. Neurochem., 73, 1999, pS146A
Hughes, R.B., Meegan, M.J., Lloyd, D.G., Williams, D.C. and Zisterer, D.M., Investigation of diaryl benzoxepines as novel antiestrogens and selective estrogen receptor modulators (SERMs), Proceedings of the 22nd Annual Pharmacy Joint Research Seminar, Queens University Belfast, 1999, 1999
Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 10th International RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK, 1999
Haase, J., Schloss, P., and Williams, D.C., Regulation of the serotonin transporter: Identification of interacting proteins using a yeast two-hybrid system, J.Neurochem., 73, 1999, pS98D
Elliott, G., Campiani, G., Drejer, J., Griffiths, R., Hildebrand, H., Meredith, C., Schousboe, A., Schmuck, G. and Williams, D.C., Demonstration of an in vitro test for excitotoxicity based on early response gene measurement, Alternatives to Laboratory Animals (ATLA), 27, 1999, p289
Marangolo, M., Zisterer, D., Williams, D.C., Tipton, K., Dixon, H. and Della Corte, L., Different specificities for taurine analogues and their target sites, J. Neurochem., 66, (suppl. 2), 1996, pS102D
Zisterer, D.M. & Williams, D.C., Hexachlorocyclohexanes inhibits steroidogenesis in Y1 cells: Absence of correlation with binding to the peripheral-type benzodiazepine receptor, J. Neurochem., 66, (suppl. 2), 1996, pS87C
Baker, C.R., Williams, D.C., Titgemeyer, F. & Robillard, G.T., Towards overexpression of the serotonin transporter in bacteria and yeast, J. Neurochem., 66, (suppl. 2), 1996, pS43C
Tarrant, H.M. & Williams, D.C., Reconstitution of the rat brain serotonin transporter, Biochem. Soc. Trans., 23, 1995, p40S
Tarrant, H.M. & Williams, D.C., Dithiothreitol promotes a higher affinity state of the serotonin transporter for the tricyclic antidepressant imipramine, Biochem. Soc. Trans., 23, 1995, p41S
Dunican, D.J., Griffiths, R., O'Neill, L.A.J., & Williams, D.C., Depolarizing levels of KCl inhibit endothelin-1-mediated release of arachidonic acid in rat C6 glioma cells, Biochem. Soc. Trans., 23, 1994, p285S
Moynagh, P.N., Williams, D.C., Gearing, A.J.H. & O'Neill, L.A.J., Induction of VCAM-1 and ICAM-1 in human glioma cells by IL-1, Lymphokine and Cytokine Research, 12, 1993, p224
Williams, D.C.(ed.), CEC Biotechnology Programme In-vitro Pharmacotoxicology Sectoral Meeting, Dublin, 1992
Williams, D.C., Abstracts of 9th General Meeting of the European Neurochemical Society, Neurochem. Int. (suppl), 21, 1992
Moynagh, P.N. & Williams, D.C., Molecular studies on the peripheral-type benzodiazepine acceptor, Biochem. Soc. Trans., 20, 1992, p267S
Moynagh, P.N., O'Neill, L.A.J. & Williams, D.C., Modulation of the peripheral-type benzodiazepine acceptor by IL-1 and PMA, Neurochem. Int., 21, 1992, pC63
Worrall, D.M., Tarrant, H.M., Mabjeesh, N.J., Williams, D.C. & Kanner, B.I., Partial purification of the human platelet 5-HT transporter and cross-reactivity with antibodies to the rat brain GABA transporter, Proceedings of the 21st FEBS Meeting, Dublin, 1992, ppTh77
Moynagh, P.N., Williams, D.C. & O'Neill, L.A.J., Activation of NFB by IL-1 in glial cells, Neurochem. Int., 21, 1992, pC62
Moynagh, P.N., Bailey, C.J. & Williams, D.C., Purification and Immunological Studies on the Peripheral-type Benzodiazepine Acceptor, Biochem. Soc. Trans., 19, 1991, p115
Williams, D.C., Strategies for Studying Membrane Proteins of the Nervous System, Biochem. Soc. Trans., Joint Membrane Group, Neurochem. Group, Pharmacological Biochemical Group Colloquium, Biochemical Society Meeting No. 636, Trinity College, Dublin, September, 19, 1991, pp79 - 151
Williams, D.C. & Phillips, O.M., Probing the platelet plasma-membrane 5-hydroxytryptamine transporter, Biochem. Soc. Trans., 19, 1991, p112 - 114
Maher, W.J., Phillips, O.M. & Williams D.C., The Design of photo-affinity labels for the characterisation of the 5-hydroxytryptamine transporter on human platelet membranes, Biochem. Soc. Trans., 19, 1991, p105
Regan, C.M., Rodriguez-Farré, E., Schousboe, A. & Williams, D.C., CEC Biotechnology Action Programme, Final Report 1990 In-vitro sreening for Anticonvulsant-induced Teratogenesis in Neural Primary Cultures and Cell Lines, 1990
Phillips, O.M., Wood, K.M. & Williams, D.C., Kinetics of the Interaction of Sertraline with the Human Platelet Plasma Membrane 5-Hydroxytryptamine Carrier, Neuropsychopharmacology, 96, 1989, p269
Regan, C.M., Schousboe, A. & Williams, D.C., CEC Biotechnology Action Programme, Progress Report 1989. In-vitro sreening for Anticonvulsant-induced Teratogenesis in Neural Primary Cultures and Cell Lines, 1989
Regan, C.M., Schousboe, A. & Williams, D.C., CEC Biotechnology Action Programme, Progress Report 1988, In-vitro screening for Anticonvulsant-induced Teratogenesis in Neural Primary Cultures and Cell Lines, 1988
O'Callaghan, A.M., Phillips, O.M. & Williams, D.C., Production of Rabbit Anti-imipramine Antibodies, Biochem. Soc. Trans., 15, 1987, p274 - 275
McInerney, M. & Williams, D.C., Purification and properties of calmodulin-activated phosphodiesterase from bovine brain, Biochem. Soc. Trans., 15, 1987, p275 - 276
O'Beirne, G.B. & Williams, D.C., Enrichment of rat liver and kidney 'peripheral-type' benzodiazepine-binding sites in plasma membrane-derived fractions, Biochem. Soc. Trans., 14, 1986, p594 - 595
Williams, D.C., Gorman, A.M.C., O'Beirne, G.B. & Regan, C.M., Inhibition of brain cell proliferation by benzodiazepines, Biochem. Soc. Trans., 14, 1986, p595 - 596
O'Riordan, C., Phillips, O.M. & Williams, D.C., Solubilisation of Human Platelet Plasma Membrane 5-Hydroxytryptamine Carrier with Retention of Native Properties, Biochem. Soc. Trans., 14, 1986, p596 - 597
Williams, D.C., O'Riordan, C., Beattie, R.E. & O'Neill, C.M., Multiple Forms of Calmodulin on SDS-Polyacrylamide-gel Electrophoresis, Biochem. Soc. Trans., 12, 1984, p472 - 474
Griffiths, R., Williams, D.C., O'Neill, C., Dewhurst, I.C. & Ekuwem, C.E., Synergistic Inhibition of [3H]-Muscimol Binding to Calf Brain Synaptic Membranes by L-Homocysteine and Pyridoxal Phosphate, J Neurochem (Abstr), 41 (Suppl), 1983, p526
Summers, M.C. & Williams, D.C., Enzyme Chemistry, Ann. Reports Chem. Soc., B, (Chapter 14 (IV)), 1978, p432 - 446
John, R.A., Bryce, C.F.A., Williams D.C. & Fasella, P., Anomalous Kinetics of Coupled Aspartate Aminotransferase and Malic Dehydrogenase, Proc. 10th FEBS Meeting, Paris, 1975
Research Expertise
Description
Current Research Interests and ProjectsRecognition
Representations
Member and sometime Chair of The National Committee for Biochemistry
Secretary and Member of The Neurochemical Group Committee of The Biochemical Society
Member of HRB Mental Health and Neurology, and Post-doctoral Fellowship Research Grants Committees
Trustee of The Irish Area Section of The Biochemical Society FEBS Fund for Graduate students
External examiner for research degrees in St Andrews, Leeds, Cardiff, Galway, Cork, Aarhus, etc
Chairman Organising committee for EU TMR Euroconference on Neuronal Transporters Dublin 1998
Member Organising Committees for 636 and 648th Biochemical Society Meeting - Dublin 1990, 2002, 21st FEBS Meeting -Dublin 1992, INSERM Phillipe Laudet Conference on Neuronal transporters - Strasbourg, 1993
NUI Phelan Scholarship Evaluation Panel
Chair of Local Organising Committee, and Member of International Programme Committee for the 9th General Meeting of the European Society for Neurochemistry, Dublin 1992
Awards and Honours
Elected Fellow of Trinity College
Elected To Membership of Royal Irish Academy
Memberships
Member of the Society for Neuroscience
Member and Council Member of European Society for Neurochemistry
Member of The International Society for Neurochemistry
Royal Irish Academy
The Biochemical Society