Dr. Suzanne Cloonan
Professor in Respiratory Biochemistry, Clinical Medicine Tallaght
Biography
Dr. Cloonan is a Professor in Respiratory Biochemistry in the School of Medicine at Trinity College Dublin as well as an Adjunct Assistant Professor of Biochemistry in Medicine at Weill Cornell Medical College. Dr. Cloonan received her PhD in Biochemistry in 2010 from Trinity College Dublin Ireland. She carried out her Post-Doctoral training in the lab of Dr. Augustine MK Choi in The Division of Pulmonary and Critical Care Medicine, Brigham and Women"s Hospital, Harvard Medical School, Boston. In 2014, she became faculty at Weill Cornell Medicine having obtained funding from the National Institute of Health (K99/R00 award) and the American Lung Association to understand the role of mitochondrial dysfunction and iron metabolism in the development of Chronic Obstructive Pulmonary Disease (COPD). After obtaining Science Foundation Ireland Future Research Leaders Award, she relocated her lab to Trinity College Dublin as an Associate Professor in 2020. Her lab is focused on applying cutting edge techniques and concepts to aid in understanding the molecular mechanisms behind iron metabolism in normal and diseased lung; related to inflammation, alveolar epithelial cell biology, host-pathogen interactions in the lung microenvironment and subsequent systemic implications. She is currently Chair of Assembly 3.02, Airway cell biology and immunopathology and is a member of the fellowships and awards committee for the European Respiratory Society. She is also a program committee member for the Allergy, Immunology and Inflammation assembly of the American Thoracic Society and is an associate editor at Scientific Reports and Respiratory Research.
Publications and Further Research Outputs
Peer-Reviewed Publications
Chung, K.-P. and Cheng, C.-N. and Chen, Y.-J. and Hsu, C.-L. and Huang, Y.-L. and Hsieh, M.-S. and Kuo, H.-C. and Lin, Y.-T. and Juan, Y.-H. and Nakahira, K. and Chen, Y.-F. and Liu, W.-L. and Ruan, S.-Y. and Chien, J.-Y. and Plataki, M. and Cloonan, S.M. and Carmeliet, P. and Choi, A.M.K. and Kuo, C.-H. and Yu, C.-J., Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation, Nature Communications, 15, (1), 2024
Faherty, L. and Zhang, W.Z. and Salih, M.M. and Robinson, E.K. and Perez, E. and Kim, K. and Carpenter, S. and Cloonan, S.M., Transcriptomic analysis reveals distinct effects of cigarette smoke on murine airspace and bone-marrow derived macrophages, Respiratory Research, 25, (1), 2024
Salih MM, Robinson EK, Malekos E, Perez E, Capili A, Kim K, Zhang WZ, Cloonan SM, Carpenter S., LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages., American journal of respiratory cell and molecular biology, 68, (5), 2023, p511-522
Cloonan SM., "KEAP"ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease., American journal of respiratory and critical care medicine, 207, (8), 2023, p962-964
Kim K, Zhang WZ, Kikkers SA, O'Beirne SL, Strulovici-Barel Y, Kaner RJ, Crystal RG, Cloonan SM., Use of the Iron Chelator Deferiprone to Restore Function in BAL Fluid Macrophages in Smoking and Chronic Obstructive Pulmonary Disease., American journal of respiratory cell and molecular biology, 68, (4), 2023, p458-462
Salih, M.M. and Robinson, E.K. and Malekos, E. and Perez, E. and Capili, A. and Kim, K. and Zhang, W.Z. and Cloonan, S.M. and Carpenter, S., LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages, American journal of respiratory cell and molecular biology, 68, (5), 2023, p511-522
Cloonan, S.M., â KEAPâ ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine, 207, (8), 2023, p962-964
Fan LC, McConn K, Plataki M, Kenny S, Williams NC, Kim K, Quirke JA, Chen Y, Sauler M, Möbius ME, Chung KP, Area Gomez E, Choi AM, Xu JF, Cloonan SM., Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD., JCI insight, 8, (16), 2023, pe163403
Faherty, L. and Kenny, S. and Cloonan, S.M., Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD, Clinical science (London, England : 1979), 137, (3), 2023, p219-237
Cloonan SM., OLA1 Phosphorylation: A Distress Signal from Damaged Endothelial Mitochondria?, American journal of respiratory cell and molecular biology, 68, (4), 2023, p347-348
Cuevas Ocaña S, El-Merhie N, Kuipers ME, Lehmann M, Enes SR, Voss C, Dean LSN, Loxham M, Boots AW, Cloonan SM, Greene CM, Heijink IH, Joannes A, Mailleux AA, Mansouri N, Reynaert NL, van der Does AM, Wagner DE, Ubags N., ERS International Congress 2022: highlights from the Basic and Translational Science Assembly., ERJ open research, 9, (2), 2023, p561-2022
Cui, Y. and Gutierrez, S. and Ariai, S. and Ã-berg, L. and Thörn, K. and Gehrmann, U. and Cloonan, S.M. and Naessens, T. and Olsson, H., Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress, Frontiers in Immunology, 13, (998059), 2022
Williams, N.C. and Ryan, D.G. and Costa, A.S.H. and Mills, E.L. and Jedrychowski, M.P. and Cloonan, S.M. and Frezza, C. and O'Neill, L.A., Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages, Journal of Biological Chemistry, 298, (2), 2022
Sayles, N.M. and Southwell, N. and McAvoy, K. and Kim, K. and Pesini, A. and Anderson, C.J. and Quinzii, C. and Cloonan, S. and Kawamata, H. and Manfredi, G., Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy, Cell Reports, 38, (10), 2022
Ramchandani, D. and Berisa, M. and Tavarez, D.A. and Li, Z. and Miele, M. and Bai, Y. and Lee, S.B. and Ban, Y. and Dephoure, N. and Hendrickson, R.C. and Cloonan, S.M. and Gao, D. and Cross, J.R. and Vahdat, L.T. and Mittal, V., Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis, Nature Communications, 12, (1), 2021
Hisata, S. and Racanelli, A.C. and Kermani, P. and Schreiner, R. and Houghton, S. and Palikuqi, B. and Kunar, B. and Zhou, A. and McConn, K. and Capili, A. and Redmond, D. and Nolan, D.J. and Ginsberg, M. and Ding, B.-S. and Martinez, F.J. and Scandura, J.M. and Cloonan, S.M. and Rafii, S. and Choi, A.M.K., Reversal of emphysema by restoration of pulmonary endothelial cells, Journal of Experimental Medicine, 218, (8), 2021
Zhang, W.Z. and Hoffman, K.L. and Schiffer, K.T. and Oromendia, C. and Rice, M.C. and Barjaktarevic, I. and Peters, S.P. and Putcha, N. and Bowler, R.P. and Wells, J.M. and Couper, D.J. and Labaki, W.W. and Curtis, J.L. and Han, M.K. and Paine, R. and Woodruff, P.G. and Criner, G.J. and Hansel, N.N. and Diaz, I. and Ballman, K.V. and Nakahira, K. and Choi, M.E. and Martinez, F.J. and Choi, A.M.K. and Cloonan, S.M., Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort, Respiratory Research, 22, (1), 2021
Robinson, E.K. and Jagannatha, P. and Covarrubias, S. and Cattle, M. and Smaliy, V. and Safavi, R. and Shapleigh, B. and Abu-Shumays, R. and Jain, M. and Cloonan, S.M. and Akeson, M. and Brooks, A.N. and Carpenter, S., Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of aim2, eLife, 10, (e69431), 2021
Healy, C. and Munoz-Wolf, N. and Strydom, J. and Faherty, L. and Williams, N.C. and Kenny, S. and Donnelly, S.C. and Cloonan, S.M., Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease, Respiratory Research, 22, (1), 2021
Lam, H.C. and Cloonan, S.M. and Bhashyam, A.R. and Haspel, J.A. and Singh, A. and Fah Sathirapongsasuti, J. and Cervo, M. and Yao, H. and Chung, A.L. and Mizumura, K. and An, C.H. and Shan, B. and Franks, J.M. and Haley, K.J. and Owen, C.A. and Tesfaigzi, Y. and Washko, G.R. and Quackenbush, J. and Silverman, E.K. and Rahman, I. and Kim, H.P. and Mahmood, A. and Biswal, S.S. and Ryter, S.W. and Choi, A.M.K., Erratum: Histone deacetylase 6â"mediated selective autophagy regulates COPD-associated cilia dysfunction (Journal of Clinical Investigation (2013) 123:12 (5212-5230) DOI: 10.1172/JCI69636), Journal of Clinical Investigation, 130, (11), 2020, p6189
Zhang William Z, Oromendia Clar, Kikkers Sarah An, Butler James J, Oâ Beirne Sara, Kim Kihwa, Oâ Neal Wanda K, Freeman Christine M, Christenson Stephanie A, Peters Stephen P, Wells J. Michae, Doerschuk Clair, Putcha Nirupam, Barjaktarevic Igo, Woodruff Prescott G, Cooper Christopher B, Bowler Russell P, Comellas Alejandro P, Criner Gerard J, Paine Rober, Hansel Nadia N, Han Meilan K, Crystal Ronald G, Kaner Robert J, Ballman Karla V, Curtis Jeffrey L, Martinez Fernando J, Cloonan Suzanne M, Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS, Scientific Reports, 10, (1), 2020, p10562-
Zhang, W.Z. and Cloonan, S.M., To â Feâ ed or not to â Feâ ed: Iron depletion exacerbates emphysema development in murine smoke model, American Journal of Respiratory Cell and Molecular Biology, 62, (5), 2020, p541-542
Cloonan, S.M. and Kim, K. and Esteves, P. and Trian, T. and Barnes, P.J., Mitochondrial dysfunction in lung ageing and disease, European Respiratory Review, 29, (157), 2020
Bessman, Nicholas J and Mathieu, Jacques R R and Renassia, Cyril and Zhou, Lei and Fung, Thomas C and Fernandez, Keith C and Austin, Christine and Moeller, Jesper B and Zumerle, Sara and Louis, Sabine and Vaulont, Sophie and Ajami, Nadim J and Sokol, Harry and Putzel, Gregory G and Arvedson, Tara and Sockolow, Robbyn E and Lakhal-Littleton, Samira and Cloonan, Suzanne M and Arora, Manish and Peyssonnaux, Carole and Sonnenberg, Gregory F, Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing, Science (New York, N.Y.), 368, (6487), 2020, p186â"189
Aghapour, Mahyar and Remels, Alexander H V and Pouwels, Simon D and Bruder, Dunja and Hiemstra, Pieter S and Cloonan, Suzanne M and Heijink, Irene H, Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease, American journal of physiology. Lung cellular and molecular physiology, 318, (1), 2020, pL149â"L164
Zhang, William Z and Rice, Michelle C and Hoffman, Katherine L and Oromendia, Clara and Barjaktarevic, Igor Z and Wells, J Michael and Hastie, Annette T and Labaki, Wassim W and Cooper, Christopher B and Comellas, Alejandro P and Criner, Gerard J and Krishnan, Jerry A and Paine, Robert and Hansel, Nadia N and Bowler, Russell P and Barr, R Graham and Peters, Stephen P and Woodruff, Prescott G and Curtis, Jeffrey L and Han, Meilan K and Ballman, Karla V and Martinez, Fernando J and Choi, Augustine Mk and Nakahira, Kiichi and Cloonan, Suzanne M and Choi, Mary E and {SPIROMICS Investigators, Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort, JCI insight, 5, (3), 2020
O'Beirne, Sarah L and Kikkers, Sarah Ann and Oromendia, Clara and Salit, Jacqueline and Rostmai, Mahboubeh R and Ballman, Karla V and Kaner, Robert J and Crystal, Ronald G and Cloonan, Suzanne M, Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease, American journal of respiratory and critical care medicine, 201, (6), 2020, p735â"739
Zhang, William Z and Cloonan, Suzanne M, To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model, American journal of respiratory cell and molecular biology, 62, (5), 2020, p541â"542
Perez, E. and Baker, J.R. and Giandomenico, S.D. and Kermani, P. and Parker, J. and Kim, K. and Yang, J. and Barnes, P.J. and Vaulont, S. and Scandura, J.M. and Donnelly, L.E. and Stout-Delgado, H. and Cloonan, S.M., Hepcidin is essential for alveolar macrophage function and is disrupted by smoke in a murine chronic obstructive pulmonary disease model, Journal of Immunology, 205, (9), 2020, p2489-2498
Plataki, Maria and Fan, LiChao and Sanchez, Elizabeth and Huang, Ziling and Torres, Lisa K and Imamura, Mitsuru and Zhu, Yizhang and Cohen, David E and Cloonan, Suzanne M and Choi, Augustine Mk, Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity, JCI insight, 5, 2019
Najafinobar, Neda and Venkatesan, Shalini and von Sydow, Lena and Klarqvist, Magnus and Olsson, Henric and Zhou, Xiao-Hong and Cloonan, Suzanne M and Malmberg, Per, ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients, Scientific reports, 9, (1), 2019, p10060
Faner, R. and Morrow, J.D. and Casas-Recasens, S. and Cloonan, S.M. and Noell, G. and López-Giraldo, A. and Tal-Singer, R. and Miller, B.E. and Silverman, E.K. and AgustÃ, A. and Hersh, C.P., Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology, Respiratory Research, 20, (1), 2019
Faner, Rosa and Morrow, Jarrett D and Casas-Recasens, Sandra and Cloonan, Suzanne M and Noell, Guillaume and López-Giraldo, Alejandra and Tal-Singer, Ruth and Miller, Bruce E and Silverman, Edwin K and AgustÃ, Alvar and Hersh, Craig P, Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis, Respiratory research, 20, (1), 2019, p5
Chung, Kuei-Pin and Hsu, Chia-Lang and Fan, Li-Chao and Huang, Ziling and Bhatia, Divya and Chen, Yi-Jung and Hisata, Shu and Cho, Soo Jung and Nakahira, Kiichi and Imamura, Mitsuru and Choi, Mary E and Yu, Chong-Jen and Cloonan, Suzanne M and Choi, Augustine M K, Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis, Nature communications, 10, (1), 2019, p3390
Zhang, William Z and Butler, James J and Cloonan, Suzanne M, Smoking-induced iron dysregulation in the lung, Free radical biology & medicine, 133, 2019, p238â"247
Ward, Diane M and Cloonan, Suzanne M, Mitochondrial Iron in Human Health and Disease, Annual review of physiology, 81, 2019, p453â"482
Burstein, S.R. and Valsecchi, F. and Kawamata, H. and Bourens, M. and Zeng, R. and Zuberi, A. and Milner, T.A. and Cloonan, S.M. and Lutz, C. and Barrientos, A. and Manfredi, G., In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions, Human Molecular Genetics, 27, (1), 2018, p160-177
Ma, Kevin C and Schenck, Edward J and Siempos, Ilias I and Cloonan, Suzanne M and Finkelsztein, Eli J and Pabon, Maria A and Oromendia, Clara and Ballman, Karla V and Baron, Rebecca M and Fredenburgh, Laura E and Higuera, Angelica and Lee, Jin Young and Chung, Chi Ryang and Jeon, Kyeongman and Yang, Jeong Hoon and Howrylak, Judie A and Huh, Jin-Won and Suh, Gee Young and Choi, Augustine Mk, Circulating RIPK3 levels are associated with mortality and organ failure during critical illness, JCI insight, 3, (13), 2018
Racanelli, Alexandra C and Kikkers, Sarah Ann and Choi, Augustine M K and Cloonan, Suzanne M, Autophagy and inflammation in chronic respiratory disease, Autophagy, 14, (2), 2018, p221â"232
Pabón, Maria A and Patino, Edwin and Bhatia, Divya and Rojas-Quintero, Joselyn and Ma, Kevin C and Finkelsztein, Eli J and Osorio, Juan C and Malick, Faryal and Polverino, Francesca and Owen, Caroline A and Ryter, Stefan W and Choi, Augustine Mk and Cloonan, Suzanne M and Choi, Mary E, Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease, JCI insight, 3, (18), 2018
Cloonan, S.M. and Mumby, S. and Adcock, I.M. and Choi, A.M.K. and Chung, K.F. and Quinlan, G.J., The iron-y of iron overload and iron deficiency in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, 196, (9), 2017, p1103-1112
Morrow, Jarrett D and Zhou, Xiaobo and Lao, Taotao and Jiang, Zhiqiang and DeMeo, Dawn L and Cho, Michael H and Qiu, Weiliang and Cloonan, Suzanne and Pinto-Plata, Victor and Celli, Bartholome and Marchetti, Nathaniel and Criner, Gerard J and Bueno, Raphael and Washko, George R and Glass, Kimberly and Quackenbush, John and Choi, Augustine M K and Silverman, Edwin K and Hersh, Craig P, Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue, Scientific reports, 7, 2017, p44232
Cloonan, Suzanne M, Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis, American journal of respiratory and critical care medicine, 196, (12), 2017, p1502â"1504
Cloonan, Suzanne M and Mumby, Sharon and Adcock, Ian M and Choi, Augustine M K and Chung, Kian Fan and Quinlan, Gregory J, The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease, American journal of respiratory and critical care medicine, 196, (9), 2017, p1103â"1112
Mizumura, Kenji and Cloonan, Suzanne and Choi, Mary E and Hashimoto, Shu and Nakahira, Kiichi and Ryter, Stefan W and Choi, Augustine M K, Autophagy: Friend or Foe in Lung Disease?, Annals of the American Thoracic Society, 13 Suppl 1, 2016, pS40â"7
Cloonan, Suzanne M and Glass, Kimberly and Laucho-Contreras, Maria E and Bhashyam, Abhiram R and Cervo, Morgan and Pabón, Maria A and Konrad, Csaba and Polverino, Francesca and Siempos, Ilias I and Perez, Elizabeth and Mizumura, Kenji and Ghosh, Manik C and Parameswaran, Harikrishnan and Williams, Niamh C and Rooney, Kristen T and Chen, Zhi-Hua and Goldklang, Monica P and Yuan, Guo-Cheng and Moore, Stephen C and Demeo, Dawn L and Rouault, Tracey A and D'Armiento, Jeanine M and Schon, Eric A and Manfredi, Giovanni and Quackenbush, John and Mahmood, Ashfaq and Silverman, Edwin K and Owen, Caroline A and Choi, Augustine M K, Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice, Nature medicine, 22, (2), 2016, p163â"174
Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria in lung disease, The Journal of clinical investigation, 126, (3), 2016, p809â"820
Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505
Cloonan, S.M. and Lam, H.C. and Ryter, S.W. and Choi, A.M., Ciliophagy : The consumption of cilia components by autophagy, Autophagy, 10, (3), 2014, p532-534
Mizumura, Kenji and Cloonan, Suzanne M and Nakahira, Kiichi and Bhashyam, Abhiram R and Cervo, Morgan and Kitada, Tohru and Glass, Kimberly and Owen, Caroline A and Mahmood, Ashfaq and Washko, George R and Hashimoto, Shu and Ryter, Stefan W and Choi, Augustine M K, Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD, The Journal of clinical investigation, 124, (9), 2014, p3987â"4003
Cloonan, Suzanne M and Lam, Hilaire C and Ryter, Stefan W and Choi, Augustine M, "Ciliophagy": The consumption of cilia components by autophagy, Autophagy, 10, (3), 2014, p532â"534
McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ, Synthesis and antiproliferative action of a novel series of maprotiline analogues., European journal of medicinal chemistry, 71, 2014, p333-53
Nakahira, Kiichi and Cloonan, Suzanne M and Mizumura, Kenji and Choi, Augustine M K and Ryter, Stefan W, Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease, Antioxidants & redox signaling, 20, (3), 2014, p474â"494
Lam, Hilaire C and Cloonan, Suzanne M and Bhashyam, Abhiram R and Haspel, Jeffery A and Singh, Anju and Sathirapongsasuti, J Fah and Cervo, Morgan and Yao, Hongwei and Chung, Anna L and Mizumura, Kenji and An, Chang Hyeok and Shan, Bin and Franks, Jonathan M and Haley, Kathleen J and Owen, Caroline A and Tesfaigzi, Yohannes and Washko, George R and Quackenbush, John and Silverman, Edwin K and Rahman, Irfan and Kim, Hong Pyo and Mahmood, Ashfaq and Biswal, Shyam S and Ryter, Stefan W and Choi, Augustine M K, Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction, The Journal of clinical investigation, 123, (12), 2013, p5212â"5230
Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: sensors and mediators of innate immune receptor signaling, Current opinion in microbiology, 16, (3), 2013, p327â"338
Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: sensors and mediators of innate immune receptor signaling, Current opinion in microbiology, 16, (3), 2013, p327â"338
Ryter, Stefan W and Cloonan, Suzanne M and Choi, Augustine M K, Autophagy: a critical regulator of cellular metabolism and homeostasis, Molecules and cells, 36, (1), 2013, p7â"16
Breen, JM, Clerac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, and Schmitt, W., Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages, Dalton Transactions, 41, (10), 2012, p2918 - 2926
Mizumura, Kenji and Cloonan, Suzanne M and Haspel, Jeffrey A and Choi, Augustine M K, The emerging importance of autophagy in pulmonary diseases, Chest, 142, (5), 2012, p1289â"1299
Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: commanders of innate immunity and disease?, Current opinion in immunology, 24, (1), 2012, p32â"40
Constantin, Myrna and Choi, Alexander J S and Cloonan, Suzanne M and Ryter, Stefan W, Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease, International journal of hypertension, 2012, 2012, p859235
Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T, Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents., Journal of the American Chemical Society, 133, (40), 2011, p15862 - 15865
Yvonne M. McNamara, Suzanne M. Cloonan, Andrew J.S. Knox, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams, Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry, 19, (3), 2011, p1328 - 1348
Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, p686 - 688
Cloonan, S.M. and Williams, D.C. , The antidepressants maprotiline and fluoxetine induce Type-II autophagic cell death in drug resistant Burkitt's lymphoma, International Journal of Cancer, 128, 2011, p1712 - 1723
Cloonan SM, Drozgowska A, Fayne D, Williams DC, The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters., Leukemia & lymphoma, 51, (3), 2010, p523-39
Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507
Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted á-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 18, 2010, p4009 - 4031
Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888
Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70
Research Expertise
Projects
- Title
- The Ironome of the Lung and Disease Pathogenesis
- Funding Agency
- Science Foundation Ireland
- Date From
- 2019
- Date To
- 2024
- Title
- IRONWARS: The battle for IRON in the alveolar space underlies susceptibility to COPD
- Summary
- COPD is the most prevalent respiratory disease in adults affecting over 170 million people globally and tops all non-communicable respiratory diseases combined in mortality. While COPD is already the third leading cause of death worldwide, death rates from COPD are predicted to rapidly intensify due to a rising and ageing global population, outweighing any potential improvements in care. With little or no advances in therapy in decades, COPD is irreversible and inexorably progressive leading to a severe impairment in quality of life. Given the burden of COPD on human health, new and better personalised therapies are therefore desperately needed.
- Funding Agency
- Irish Research Council
- Date From
- 01-01-2023
Recognition
Representations
Conference Organising Committee Pittsburgh International Lung Conference Dublin
Chair Assembly 3.02, Airway cell biology and immunopathology, European Respiratory Society
Programme Committee American Thoracic Society Assembly on Allergy, Immunology, and Inflammation (AII) This assembly is concerned with allergic, immunologic, and inflammatory mechanisms affecting the respiratory system in health and disease.
Associate Editor Respiratory Research
Associate Editor, Scientific Reports
Nominating Committee, RCMB Assembly, American Thoracic Society
CONFERENCE ORGANIZER International Biorion Society Scientific Committee member
CONFERENCE CHAIR/ORGANIZER European Respiratory Society Annual Conference 2019 Scientific Reviewer
CONFERENCE CHAIR/ORGANIZER American Thoracic Society Annual Conference Program Committee
CONFERENCE CHAIR/ORGANIZER American Thoracic Society Annual Conference. Chair: Mitochondrial dysfunction and reprogramming in lung aging and disease.
Awards and Honours
Irish Research Council Laureate Award
Science Foundation ireland Future Research Leaders Award
Kellen Fellowship for Junior Faculty, Weill Cornell Medicine
Weill Cornell Medicine, Junior Faculty Development Grant
American Thoracic Society Annual Conference Best Abstract Award
National Cancer Institute/Health Research Board Ireland Molecular Prevention/Control Scholar
Irish Association for Cancer Research Travel Award
Memberships
European Respiratory Society
American Thoracic Society
Bioiron Society
Irish Thoracic Society
American Association for Cancer Research
Irish Association for Cancer Research