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Dr. Mary Canavan
Assistant Professor, Biochemistry

Biography

My research focuses on understanding the immunological mechanisms which drive the development of autoimmune diseases,such Rheumatoid Arthritis. We explore the role of innate and adaptive immunity in the pathogenesis of RA. By using physiologically relevant ex-vivo models, across multiple disease stages, we aim to identify new biomarkers for disease onset, therapeutic response and disease severity. Finally, we collaborate with several pharmaceutical companies, clinicians, translational scientists and patients to maximise the impact of our work and ensure the successful translation of our findings from bench to bedside.

Publications and Further Research Outputs

Peer-Reviewed Publications

Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022 Journal Article, 2022

Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021 Journal Article, 2021 DOI

Viviana Marzaioli, Mary Canavan, Alex Donnolly, Siobhan Wade, Alexander Fraser, Tim O'Sullivan, Sinead Harney, Arthritis Ireland, Douglas J. Veale, Ursula Fearon, Knowledge of disease, diagnosis, adherence and impact of research in an Irish cohort of patients with inflammatory arthritis, HRB Open Research, 4, 2021, p60 Journal Article, 2021 DOI

Hanlon MM, Canavan M, Barker BE, Fearon U., Metabolites as drivers and targets in Rheumatoid Arthritis., Clinical and experimental immunology, 2021 Journal Article, 2021 DOI

Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ, Fearon U., ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis, Cells, ;10(3):, (64), 2021, pdoi: 10.33- Journal Article, 2021

Canavan M, Marzaioli V, Bhargava V, Nagpal S, Gallagher P, Hurson C, Mullan R, Veale DJ, Fearon U, Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium., Frontiers in immunology, 2021 Journal Article, 2021 DOI

Foley, C., Floudas, A., Canavan, M., Biniecka, M., MacDermott, E. J., Veale, D. J., Mullan, R. H., Killeen, O. G., Fearon, U., Increased T Cell Plasticity With Dysregulation of Follicular Helper T, Peripheral Helper T, and Treg Cell Responses in Children With Juvenile Idiopathic Arthritis and Down Syndrome"Associated Arthritis, Arthritis & Rheumatology, 72, (4), 2020, p677-686 Journal Article, 2020 DOI

Canavan M, Wade SM, Veale DJ, Fearon U, Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al., Annals of the rheumatic diseases, 2020 Journal Article, 2020 DOI

Canavan M, Marzaioli V, McGarry T, Bhargava V, Nagpal S, Veale DJ, Fearon U., Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells., Clin Exp Immunol, Nov;202(2):226-238., 2020 Journal Article, 2020

Marzaioli V, Canavan M, Floudas A, Wade SC, Low C, Veale DJ, Fearon U., Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation., Front Immunol, Jul 7;11:1406., 2020 Journal Article, 2020

Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U., Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis., EBioMedicine. , Sep;47:, 2019, p402 - 413 Journal Article, 2019

Wade SM, Canavan M, McGarry T, Low C, Wade SC, Mullan RH, Veale DJ, Fearon U, Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis., (Jan 10th), 2019 Journal Article, 2019

Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U, Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis., JCI Insight, 3, (23), 2018, p95228- Journal Article, 2018 TARA - Full Text DOI

Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale, Fearon U, Nagpal S, Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression., PloS one, 2018 Journal Article, 2018

O'Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M, The pathogenic role of dendritic cells in non-infectious anterior uveitis., Experimental eye research, 2018, p121 - 128 Journal Article, 2018 DOI

Wade SM, Trenkmann M, McGarry T, Canavan M, Marzaioli V, Wade SC, Veale DJ, Fearon U, Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B., J Autoimmunity, S0896-84, (S0896-84), 2018 Journal Article, 2018

McGarry T 1 , Biniecka M 1 , Gao W 1 , Cluxton D 2 , Canavan M 1 , Wade S 3 , Wade S 1 , Gallagher L 1 , Orr C 1 , Veale DJ 1 , Fearon U , Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis, Science Reports, 7, (22), 2017, p43165- Journal Article, 2017

Nikiphorou E, Studenic P, Alunno A, Canavan M, Jani M, Berenbaum F, 'Twitterland': a brave new world?, Annals of the rheumatic diseases, 2017 Journal Article, 2017 DOI

Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C, McGarry T, Canavan M, Kelly S, Lin TA, Liu X, Proudman SM, Veale DJ, Pitzalis C, Nagpal S., CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression., Journal of immunology (Baltimore, Md. : 1950), 198, (11), 2017, p4490-4501 Journal Article, 2017 DOI

Nikiphorou E, Studenic P, Ammitzbøll CG, Canavan M, Jani M, Ospelt C, Berenbaum F, EMEUNET., Social media use among young rheumatologists and basic scientists: results of an international survey by the Emerging EULAR Network (EMEUNET)., Annals of the rheumatic diseases, 76, (4), 2017, p712-715 Journal Article, 2017 DOI

Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells, Journal of Immunology, 2017 Journal Article, 2017 DOI

Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200 Journal Article, 2016 DOI

Fearon U, Canavan M, Biniecka M, Veale DJ, Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis., 2016 Journal Article, 2016

Basdeo, S.A., Moran, B., Cluxton, D., (...), Fearon, U., Fletcher, J.M., Polyfunctional, pathogenic CD161+ Th17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity, Journal of Immunology, 195, (2), 2015, p528-540 Journal Article, 2015 DOI

Draper E, DeCourcey J, Higgins SC, Canavan M, McEvoy F, Lynch M, Keogh B, Reynolds C, Roche HM, Mills KH, Loscher CE, Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses., The Journal of nutritional biochemistry, 25, (7), 2014, p741-9 Journal Article, 2014 DOI

Canavan, M., McCarthy, C., Larbi, N.B., Dowling, J.K., Collins, L., O'Sullivan, F., Hurley, G., Murphy, C., Quinlan, A., Moloney, G., Darby, T., Macsharry, J., Kagechika, H., Moynagh, P., Melgar, S., Loscher, C.E., Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-"Bp50, Innate Immunity, 20, (7), 2014, p675-687 Journal Article, 2014 DOI

Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928 Journal Article, 2013 TARA - Full Text DOI

Eve Draper, Clare M. Reynolds, Mary Canavan, Kingston H. Mills, Christine E. Loscher, and Helen M. Roche, Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma, Journal of Nutritional Biochemistry, 22, (8), 2011, p784-790 Journal Article, 2011 TARA - Full Text

Research Expertise

Keywords

Innate immunology; Rheumatology and rheumatological disorders