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Dr. Andrei Budanov
Ussher Assistant Professor, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardi M, Budanov A, Garcia-Prat L, Sandri M, Thomson D, Karin M, Lee JH, and Munoz-Canoves P., Sestrin prevents muscle atrophy from disuse and aging by integrating anabolic and catabolic signals., Nature Communications, 11, (1), 2020, p189- Journal Article, 2020 TARA - Full Text DOI

Irina E. Kovaleva, Artem V. Tokarchuk, Andrei O. Zheltukhin, Alexandra A. Dalina, Grigoriy Safronov, Aleksandra G. Evstafieva, Konstantin G. Lyamzaev,, Peter M. Chumakov2, and Andrei V. Budanov1,2*, Mitochondrial localization of SESN2, PLOS One, 15, (4), 2020, pe0226862- Journal Article, 2020 TARA - Full Text DOI

Kovaleva IE, Tokarchuk AV, Zheltukhin AO, Dalina AA, Lyamzaev KG, Haidurov A, Chumakov PM, and Budanov AV, Mitochondrial Localization and Function of SESN2, FASEBJ, Experimental Biology 2020, San Diego, April 4-7, 2020, 33, 2020 Conference Paper, 2020

Haidurov A and Budanov AV., Sestrin family - the stem controlling healthy ageing, Mechanisms of Ageing and Development, 192, (111379), 2020, p10 Journal Article, 2020 TARA - Full Text

Ding B, Haidurov A, Chawla A, Parmigiani A, Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, and Budanov AV., p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis., Oncotarget, 10, (65), 2019, p6997 - 7009 Journal Article, 2019 DOI TARA - Full Text

Budanov A, Dalina A, Kovaleva I, Haidurovs A, Tokarchuk A, Zheltukhin A., Sestrins regulate respiration and cell death through interaction with mitochondria., FEBS Open Bio, The 44th FEBS Congress, Krakow, Poland, July 6-11, 2019, 9, 2019, pp144 - 145 Conference Paper, 2019 DOI TARA - Full Text

Budanov AV, Ding B, Parmigiani A, Chumakov PM, Lee JH, Chawla A, Grossman S., Sestrin2 supports lung tumor growth in early stages of cancer development in mice but might play a tumor suppressive role in the late stages of carcinogenesis., FASEB Journal, Experimental Biology 2018, San Diego, April 21-25, 32, (1), 2018, ppS Lb150- Conference Paper, 2018 URL

Zeltukhin AO, Ilyinskaya GV, Budanov AV, and Chumakov PM., Some Phenotypic Characteristics of Nematode Caenorhabditis elegans Strains with Defective Functions of the Sestrin (cSesn) gene., Biomedical & Pharmacology Journal, 11, (2), 2018, p759 - 767 Journal Article, 2018 DOI

Dalina AA, Kovaleva IE, and Budanov AV., Sestrins are Gatekeepers in the Way from Stress to Aging and Disease., Molecular Biology, 52, (6), 2018, p823 - 835 Journal Article, 2018 DOI

Evstafieva AG, Kovaleva IE, Shoshinova MS, Budanov AV, and Chumakov PM., Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response., PLOS one, 13, (2), 2018, pe0191107- Journal Article, 2018 DOI

Budanov A, Evstafieva A, Dalina A, Kovaleva I, Zheltukhin A, Chumakov P, Taylor J., Sestrin2 protects against cell death in response to DNA-damaging drugs through regulation of ROS and mitochondrial function., FEBS Open Bio, FEBS 2018, Prague, Czech Republic, July 7-12, 2018, 8, (342), 2018, pp10-149-T- Conference Paper, 2018 URL

Oricchio E, Katanayeva N, Donaldson MC, Sungalee S, Pasion JP, Béguelin W, Battistello E, Sanghvi VR, Jiang M, Jiang Y, Teater M, Parmigiani A, Budanov AV, Chan FC, Shah SP, Kridel R, Melnick AM, Ciriello G, Wendel HG., Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma., Science Translational Medicine, 9, (396), 2017, peaak9969- Journal Article, 2017 DOI

Zhao B, Shah P, Qiang L, He TC, Budanov A, He YY, Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes., Photochemistry and photobiology, 93, (1), 2017, p375 - 381 Journal Article, 2017 DOI

Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV, Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death., Scientific Reports, 6, (22538), 2016, p14 Journal Article, 2016 TARA - Full Text DOI

Sensing the Environment Through Sestrins: Implications for Cellular Metabolism. in, editor(s)Kwan W. Jeon and Lorenzo Galluzzi , International Review of Cell and Molecular Biology, Elsevier, 2016, pp1 - 24, [Parmigiani A, Budanov AV] Book Chapter, 2016 DOI

Tsilioni I, Filippidis AS, Kerenidi T, Budanov AV, Zarogiannis SG, Gourgoulianis KI, Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells., Clinical Biochemistry, 49, (9), 2016, p726 - 728 Journal Article, 2016 TARA - Full Text DOI

Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J, Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart., FASEB Journal, 29, (2), 2015, p408 - 417 Journal Article, 2015 DOI

Zhao, B; Shah, P ; Budanov, A ; Qiang, L ; Ming, M ; Aplin, A ; Sims, D ; He, Y, Sestrin2 positively regulates AKT signaling and survival in human squamous cell carcinoma and melanoma cells, JOURNAL OF INVESTIGATIVE DERMATOLOGY, Annual Meeting of the Society-for-Investigative-Dermatology, Atlanta, GA, MAY 06-09, 135, NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA, 2015, ppS18 - S18 Conference Paper, 2015 URL

Ding B, Parmigiani A, Yang C, Budanov AV, Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation., Cell Cycle, 14, (20), 2015, p3231 - 3241 Journal Article, 2015 DOI

Budanov AV, SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR., Molecular & Cellular Oncology, 2, (3), 2015, p3 Journal Article, 2015 DOI

The role of tumor suppressor p53 in the antioxidant defense and metabolism. in, editor(s)Swati Palit Deb and Sumitra Deb , Mutant p53 and MDM2 in Cancer, Netherlands, Springer, 2014, pp337 - 358, [Budanov AV] Book Chapter, 2014 DOI

Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV, Sestrins inhibit mTORC1 kinase activation through the GATOR complex., Cell Reports, 9, (4), 2014, p1281 - 1291 Journal Article, 2014 TARA - Full Text DOI

Zhao B, Shah P, Budanov AV, Qiang L, Ming M, Aplin A, Sims DM, He YY, Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells., Journal of Biological Chemistry, 289, (52), 2014, p35806 - 3514 Journal Article, 2014 DOI

Lee JH, Budanov AV, Karin M, Sestrins orchestrate cellular metabolism to attenuate aging., Cell Metabolism, 18, (6), 2013, p792 - 801 Journal Article, 2013 DOI TARA - Full Text

Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF, Bost F, Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death., Cell Death and Differentiation, 20, (4), 2013, p611 - 619 Journal Article, 2013 DOI

Morrison-Nozik, A ; Tong, C ; Lee, JH ; Budanov, A ; Karin, M ; Li, J , Sestrin2 is cardioprotective against ischemia/reperfusion injury by promoting LKB1-mediated AMPK activation, FASEB JOURNAL, Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), Boston, MA, APR 20-24, 27, FEDERATION AMER SOC EXP BIOL, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA, 2013, pp1 Conference Paper, 2013 URL

Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M, Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3., Cell Metabolism, 16, (3), 2012, p311 - 321 Journal Article, 2012 TARA - Full Text DOI

Sestrins Link Tumor Suppressors with the AMPK -TOR Signaling Network in, editor(s)Cai Huang , Protein Phosphorylation in Human Health, Nvi Sad, Croatia, InTech, 2012, pp51 - 96, [Andrei V. Budanov] Book Chapter, 2012 URL TARA - Full Text

Park, EJ ; Dhar, D ; Lee, J ; Kim, H ; Li, N ; Ali, SR ; Budanov, AV ; Paik, YH ; Iwaisako, K ; Karin, M ; Brenner, D ; Seki, E, IL-6/STAT3-INDUCED MTOR AND AUTOPHAGY SIGNALING IN OBESITY-PROMOTED LIVER CANCER, 62nd Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD), San Francisco, CA, NOV 04-08, 54, WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA, 2011, pp388A - 388A Conference Paper, 2011 URL

Budanov AV, Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling., Antioxidant & Redox Signaling, 15, (6), 2011, p1679 - 1690 Journal Article, 2011 DOI

Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M, Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies., Science, 327, ( 5970), 2010, p1223 - 1228 Journal Article, 2010 DOI

Budanov AV, Lee JH, Karin M, Stressin' Sestrins take an aging fight., EMBO Molecular Medicine, 2, (10), 2010, p388 - 400 Journal Article, 2010 DOI TARA - Full Text

Lee, JH ; Budanov, AV ; Bier, E ; Karin, M, Sestrin, a novel regulator of TOR-dependent cell growth and metabolism, DEVELOPMENTAL BIOLOGY, 68th Annual Meeting of the Society-for-Developmental-Biology, San Francisco, CA, JUL 23-27, 331, (2), ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA, 2009, pp481 - 481 Conference Paper, 2009 URL

Budanov AV, Karin M, p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling., Cell, 134, (3), 2008, p451 - 460 Journal Article, 2008 DOI TARA - Full Text

Kochetkov DV, Il'inskaia GV, Komarov PG, Strom E, Agapova LS, Ivanov AV, Budanov AV, Frolova EI, Chumakov PM, Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53, Molecular Biology, 41, (3), 2007, p515 - 523 Journal Article, 2007 URL TARA - Full Text

Sablina AA, Budanov AV, Ilyinskaya GV, Agapova LS, Kravchenko JE, Chumakov PM, The antioxidant function of the p53 tumor suppressor., Nature Medicine, 11, (12), 2005, p1306 - 1313 Journal Article, 2005 DOI

Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM, Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors., Molecular Biology, 39, (2), 2005, p286 - 293 Journal Article, 2005 URL TARA - Full Text

Razorenova OV, Agapova LS, Budanov AV, Ivanov AV, Strunina SM, Chumakov PM, [Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors]., Gene, 350, (1), 2005, p89 - 98 Journal Article, 2005 DOI

Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM, Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD., Science, 304, (5670), 2004, p596 - 600 Journal Article, 2004 DOI

Gurova KV, Rokhlin OW, Budanov AV, Burdelya LG, Chumakov PM, Cohen MB, Gudkov AV, Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells., Cancer Research, 63, (11), 2003, p2905 - 2912 Journal Article, 2003 URL

Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y, Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E, Leshkowitz D, Einat P, Skaliter R, Feinstein E, Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis., Molecular and Cellular Biology, 22, (7), 2002, p2283 - 2293 Journal Article, 2002 DOI

Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E, Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability., Oncogene, 21, (39), 2002, p6017 - 6031 Journal Article, 2002 DOI

Smirnov AS, Ruzov AS, Budanov AV, Prokhortchouk AV, Ivanov AV, Prokhortchouk EB, High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells., Cell Death and Differentiation, 8, (6), 2001, p621 - 630 Journal Article, 2001 DOI

Smirnov AS, Budanov AV, Ruzov AS, Ivanov AV, Prokhorchuk AV, Gnuchev NV, Prokhorchuk EB, A high constitutive level of NF-kappa B is necessary for viability of murine adenocarcinoma cells--possible role of p53, Molecular Biology, 35, (5), 2000, p775 - 782 Journal Article, 2000 URL

Neverova ME, Budanov AV, Adamskaia EI, Prasolov VS, Kalinin ME, Construction by using retrovirus vector of recombinant with synthetic bradykinin "gene" for investigations of human gene expression in mammalian cells., Vestnik Rossiiskoi akademii meditsinskikh nauk, 5, 2000, p33 - 35 Journal Article, 2000

Research Expertise

Keywords

(HUMAN); 2 ISOFORMS; Ageing; Apoptosis; Cancer; GATOR; Metabolism; Mitochondria; mTOR; Sestrins; Stress Response