Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search

Dr. Nigel John Stevenson
Assistant Professor in Immunology, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

Efstathiou C, Abidi SH, Harker J and Stevenson NJ., Revisiting Respiratory Syncytial Virus's Interaction with Host Immunity, Towards Novel Therapeutics, Cellular and Molecular Life Sciences, 2020 Journal Article, 2020

Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C and Stevenson NJ, The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3, The FASEB Journal, 33, (8), 2019, p8732 - 8744 Journal Article, 2019 TARA - Full Text

Gargan, S. and Ahmed, S. and Mahony, R. and Bannan, C. and Napoletano, S. and O'Farrelly, C. and Borrow, P. and Bergin, C. and Stevenson, N.J., HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction, EBioMedicine, 30, 2018, p203-216 Journal Article, 2018 TARA - Full Text DOI

Bourke NM, Napoletano S, Bannan C, Ahmed S, Bergin C, McKnight à , Stevenson NJ., Control of HIV infection by IFN-alpha: implications for latency and a cure., Cellular and molecular life sciences : CMLS, 75, (5), 2018, p775-783 Journal Article, 2018 DOI TARA - Full Text

Raftery N and Stevenson NJ, Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway., Cellular and Molecular Life Sciences, 74, (14), 2017, p2525-2535 Review Article, 2017 DOI TARA - Full Text

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ, A novel anti-viral role for STAT3 in IFN-alpha signalling responses. , Cellular and Molecular Life Sciences, 74, (9), 2017, p1755 - 1764 Journal Article, 2017 TARA - Full Text DOI

Mahony R, Ahmed S, Diskin C, Stevenson NJ, SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?, Cellular and Molecular Life Sciences, 73, (17), 2016, p3323 - 3336 Review Article, 2016 TARA - Full Text

Lui PY, Jin DY, Stevenson NJ., MicroRNA: master controllers of intracellular signaling pathways., Cellular and Molecular Life Sciences, 72, (18), 2015, p3531 - 3542 Review Article, 2015 URL TARA - Full Text

Murray C1, Griffin ÉW, O'Loughlin E, Lyons A, Sherwin E, Ahmed S, Stevenson NJ, Harkin A, Cunningham C., Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C., Brain, Behaviour and Immunity,, 48, 2015, p274 - 286 Journal Article, 2015 URL TARA - Full Text

HCV Immune Evasion in, Hepatitis C Virus: Molecular Pathways and Treatments, OMICS group, 2014, [Napoletano S, Bannan C, Bergin C and Stevenson NJ] Book Chapter, 2014 DOI

Bourke NM, O'Neill M, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ and O'Farrelly C., In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients., Journal of Translational Medicine, 2014, p204- Journal Article, 2014 TARA - Full Text DOI

Collins AS, Ahmed S Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C and Stevenson NJ. , Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses. , The Journal of Leukocyte Biology, 96, (2), 2014, p255-63 Journal Article, 2014 TARA - Full Text DOI

Collins AS, McCoy CE, Lloyd AT, O'Farrelly C and Stevenson NJ. , miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling. , PLoS ONE, 8, (7), 2013, pe69090 Journal Article, 2013 TARA - Full Text DOI

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C, Hepatitis C Virus targets the Interferon-" JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes., FEBS letters, 587, (10), 2013, p1571-1578 Journal Article, 2013 DOI TARA - Full Text

Stevenson NJ, Murphy AG, Bourke NB, Keogh CA, Hegarty JE, O'Farrelly C, Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV, PLoS One, 6, (11), 2011, pe27866 Journal Article, 2011 TARA - Full Text

De La Vega, M., Kelvin, A.A., Dunican, D.J., McFarlane, C., Burrows, J.F., Jaworski, J., Stevenson, N.J., Dib, K., Rappoport, J.Z., Scott, C.J., Long, A., Johnston, J.A., The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility, Nature Communications, 2, (1), 2011, p259 Journal Article, 2011 TARA - Full Text DOI

Ryan, E.J., Stevenson, N.J., Hegarty, J.E., O'Farrelly, C., Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation, Journal of Viral Hepatitis , 18, (12), 2011, p840-851 Journal Article, 2011 TARA - Full Text DOI

Ryan, E.J., Dring, M., Ryan, C.M., McNulty, C., Stevenson, N.J., Lawless, M.W., Crowe, J., Nolan, N., Hegarty, J.E., O'Farrelly, C., Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection, Human Immunology, 71, (8), 2010, p829-832 Journal Article, 2010 DOI TARA - Full Text

Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C and Johnston JA, Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11, FEBS Letters, 584, (21), 2010, p4469-4474 Journal Article, 2010 TARA - Full Text

Stevenson, N.J., Addley, M.R., Ryan, E.J., Boyd, C.R., Carroll, H.P., Paunovic, V., Bursill, C.A., Miller, H.C., Channon, K.M., McClurg, A.E., Armstrong, M.A., Coulter, W.A., Greaves, D.R., Johnston, J.A., CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression, Journal of Leukocyte Biology, 85, (2), 2009, p289-297 Journal Article, 2009 TARA - Full Text DOI

Elliott, J., Lynch, O.T., Suessmuth, Y., Qian, P., Boyd, C.R., Burrows, J.F., Buick, R., Stevenson, N.J., Touzelet, O., Gadina, M., Power, U.F., Johnston, J.A., Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase, Journal of Virology, 81, (7), 2007, p3428-3436 Journal Article, 2007 DOI TARA - Full Text

The Role of the Immune System in Cancer. in, Infection in the cancer patient., Oxford University Press, 2006, pp19 - 41, [Stevenson NJ and Johnston JA. ] Book Chapter, 2006

Stevenson, Nigel, Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation, The Journal of Biological Chemistry, 280, (36), 2005, p31478 - 31488 Journal Article, 2005 DOI

Sommer, U., Schmid, C., Sobota, R.M., Lehmann, U., Stevenson, N.J., Johnston, J.A., Schaper, F., Heinrich, P.C., Haan, S., Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation: Contributions of Src- and receptor-tyrosine kinases, Journal of Biological Chemistry, 280, (36), 2005, p31478-31488 Journal Article, 2005 TARA - Full Text DOI

Stevenson, N.J., Haan, S., McClurg, A.E., McGrattan, M.J., Armstrong, M.A., Heinrich, P.C., Johnston, J.A., The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression, Journal of Immunology, 173, (5), 2004, p3243-3249 Journal Article, 2004 TARA - Full Text

Non-Peer-Reviewed Publications

Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly and Nigel J. Stevenson, The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)- a via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK) - mediated induction of suppressor of cytokine signaling (SOCS)3, The FASEB Journal, Aug, 2019, p8732 - 8744 Journal Article, 2019 DOI

Kelly A, Fahey R, Keogh C, Stevenson NJ, CarrollA , Siddachari R, Geoghegan J, Hegarty JE, Ryan EJ, O'Farrelly C, Cd141+ (bdca-3+) interferon lambda (ifn-λ)-producing dendritic cells are depleted in hepatitis C virus-infected liver, Immunology, 2011, 135, 2011, pp111 Conference Paper, 2011

Stevenson NJ, Ryan EJ, Keogh CA, Lloyd AT, Cormican P, Hegarty JE, O'Farrelly C. , Hepatitis C virus (HCV) regulates signal transducer and activator of transcription (STAT) protein expression to escape interferon-alpha (IFN-alpha) responses. , Immunology, 125, (1), 2008, pp71 Conference Paper, 2008

Armstrong MA, McClurg AE, Stevenson NJ, Hawkins SA, Johnston JA. , Timing of exposure to interferon beta can alter conventional dendritic cell precursor cell differentiation by upregulating IKBzeta and downregulating NFkB2/p52. , Immunology, 120, (1), 2007, pp36 Conference Paper, 2007

Stevenson NJ, Addely M, Greaves D, Johnston J. , Chemokines regulate innate immunity and chemotaxis through Suppressor Of Cytokine Signalling (SOCS) proteins., Clinical Immunology, 2006, ppS127 Conference Paper, 2006

Stevenson NJ, Haan S, McClurg A, Armstrong MA, Heinrich P, Johnston JA. , The chemoattractants IL-8 and fMLP regulate G-CSF signalling by inducing suppressor of cytokine signalling (SOCS)-1 expression., Immunology, 116, (1), 2005, pp73 Conference Paper, 2005

Stevenson NJ, Haan S, McClurg AE, McGrattan MJ, Armstrong MA, Heinrich PC, JA Johnston, The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine, Journal of Immunology, 173, (5), 2004, pp3243 - 3249 Conference Paper, 2004

Research Expertise