Padraic Fallon
Professor of Translational Immunology, Clinical Medicine
Interim IMM Director, Molecular Medicine Ireland

Biography

Professor Padraic Fallon heads the Translational Immunology Group. Prof Fallon is the Science Foundation Ireland Stokes Professor in Translational Immunology in the School of Medicine, TCD. Previously, Fallon was a Wellcome Trust Fellow in the University of Cambridge, UK, investigating immune modulation by schistosomes. Since returning to Ireland in 2001, he has continued his research, elucidating underlying mechanisms of aberrant immune function and novel therapeutic strategies for inflammatory diseases. The main diseases addressed are allergic lung inflammation (asthma), skin inflammation (eczema) and inflammatory bowel disease (ulcerative colitis and Crohn's disease). Fallon is the Director of the Paediatric Research in Translational Immunology (PRiTI) Programme, a strategic partnership between Trinity College Dublin and the National Children's Research Centre http://www.nationalchildrensresearchcentre.ie/ The PRiTI programme bridges basic and clinician scientists and focuses on the underlying inflammatory processes associated with a number of childhood diseases. Prof Fallon is also the current Director of Research for the School of Medicine.

Publications and Further Research Outputs

Peer-Reviewed Publications

Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne KJ., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer, Molecular Cancer, ( ), 2015, p0.1186/s12943-015-0310-8 Journal Article, 2015 DOI TARA - Full Text

Walker JA, Oliphant CJ, Englezakis A, Yu Y, Clare S, Rodewald HR, Belz G, Liu P, Fallon PG, McKenzie AN, Bcl11b is essential for group 2 innate lymphoid cell development, The Journal of Experimental Medicine, 212 , (6), 2015, - Journal Article, 2015 TARA - Full Text DOI

MacLeod AK, Fallon PG, Sharp S, Henderson CJ, Wolf CR, Huang JT., An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes., Molecular & Cellular Proteomics, 2015 Journal Article, 2015 TARA - Full Text DOI

Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG, PD-L1(hi) B cells are critical regulators of humoral immunity., Nature communications, 6, 2015, p5997 Journal Article, 2015 DOI

Cluxton, C.D., Caffrey, B.E., Kinsella, G.K., (...), Fares, M.A., Fallon, P.G., Functional conservation of an ancestral Pellino protein in helminth species, Scientific Reports, 5, 2015, p11687- Journal Article, 2015 DOI TARA - Full Text

Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., Journal of Allergy and Clinical Immunology, 137, (2), 2015, 482-491 Journal Article, 2015 TARA - Full Text DOI

Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., The Journal of allergy and clinical immunology, 2015 Journal Article, 2015 TARA - Full Text DOI

Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG., Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells., European Journal of Immunology, 2015 Journal Article, 2015 DOI TARA - Full Text

Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230- Journal Article, 2014 TARA - Full Text DOI

Gleeson EM, O'Donnell JS, Hams E, Ni Ainle F, Kenny BA, Fallon PG, Preston RJ. , Activated Factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine prodution from LPS-stimulated myeloid cells., Haematologica, 99, (1), 2014, p185 - 193 Journal Article, 2014 TARA - Full Text DOI

Fernandes P, O'Donnell C, Lyons C, Keane J, Regan T, O'Brien S, Fallon P, Brint E, Houston A, Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation., The Journal of Immunology, 2014 Journal Article, 2014 DOI

Khan AR, Amu S, Saunders SP, Fallon PG, The generation of regulatory B cells by helminth parasites., Methods in molecular biology (Clifton, N.J.), 1190, 2014, p143-62 Journal Article, 2014 DOI

Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN., MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion., Immunity, 41, 2014, p283 - 295 Journal Article, 2014 Other TARA - Full Text

Linehan E, Dombrowski Y, Snoddy R, Fallon PG, Kissenpfennig A, Fitzgerald DC., Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis., Aging Cell, 14, 2014, p69 - 708 Journal Article, 2014 DOI TARA - Full Text

Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Löhning M, Belkaid Y, Fallon PG, Powrie F., The alarmin IL-33 promotes regulatory T-cell function in the intestine., Nature, Jul 16, 2014 Journal Article, 2014 TARA - Full Text DOI

Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 Journal Article, 2014 DOI TARA - Full Text

Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG, IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis., Proceedings of the National Academy of Sciences of the United States of America, 111, (1), 2014, p367-72 Journal Article, 2014 DOI TARA - Full Text

Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA., Btk regulates macrophage polarization in response to lipopolysaccharide., PloS One, 21, 2014, pe85834. Journal Article, 2014 DOI TARA - Full Text

Aviello G, Amu S, Saunders SP, Fallon PG., A mineral extract from red algae ameliorates chronic spontaneous colitis in IL-10 deficient mice in a mouse strain dependent manner., Phytother Res., 28, 2014, p300 - 304 Journal Article, 2014 TARA - Full Text DOI

Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778 Journal Article, 2014 TARA - Full Text DOI

Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, Donowitz M, Fallon PG, Keely SJ., Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo., Gut, 63, 2014, p808 - 817 Journal Article, 2014 DOI TARA - Full Text

Khan AR, Fallon PG., Helminth therapies: translating the unknown unknowns to known knowns., Int. J. Para., 2013, p293 - 299 Review Article, 2013 DOI TARA - Full Text

O'Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, Simpson AJ, Millar AB, McGrath EE, Whyte MK, Hirani N, Hogaboam CM, Donnelly SC., The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis., Am J Respir Crit Care Med., 188, 2013, p1442 - 1450 Journal Article, 2013 DOI

Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT, Regulation of IL-1ß-induced NF-"B by hydroxylases links key hypoxic and inflammatory signaling pathways., Proceedings of the National Academy of Sciences of the United States of America, 110, (46), 2013, p18490-5 Journal Article, 2013 TARA - Full Text DOI

Hams E, Aviello G, Fallon PG., The schistosoma granuloma: friend or foe?, Front Immunol, 15, 2013, p48- Journal Article, 2013 TARA - Full Text DOI

Hams E, Locksley RM, McKenzie AN, Fallon PG., Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice., Journal of Immunology, 191, 2013, p5349 - 5353 Journal Article, 2013 TARA - Full Text DOI

Kelly OB, Mroz MS, Ward JB, Colliva C, Scharl M, Pellicciari R, Gilmer JF, Fallon PG, Hofmann AF, Roda A, Murray FE, Keely SJ., Ursodeoxycholic acid attenuates colonic epithelial secretory function., Journal of Physiology, 2013, p2307-2318 Journal Article, 2013 DOI TARA - Full Text

Enoksson M, Möller-Westerberg C, Wicher G, Fallon PG, Forsberg-Nilsson K, Lunderius-Andersson C, Nilsson G., Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent., Blood, 121, 2013, p530 - 536 Journal Article, 2013 TARA - Full Text DOI

Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, Huang LC, Johnson D, Scanlon ST, McKenzie AN, Fallon PG, Ogg GS, A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis., The Journal of experimental medicine, 210, (13), 2013, p2939-50 Journal Article, 2013 DOI TARA - Full Text

Sedhom MA, Pichery M, Murdoch JR, Foligné B, Ortega N, Normand S, Mertz K, Sanmugalingam D, Brault L, Grandjean T, Lefrancais E, Fallon PG, Quesniaux V, Peyrin-Biroulet L, Cathomas G, Junt T, Chamaillard M, Girard JP, Ryffel B., Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice., Gut, 62, 2013, p1714 - 1723 Journal Article, 2013 TARA - Full Text DOI

Scalfone LK, Nel HJ, Gagliardo LF, Cameron JL, Al-Shokri S, Leifer CA, Fallon PG, Appleton JA., Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis., Infect Immun, 81, 2013, p1354 - 1363 Journal Article, 2013 DOI TARA - Full Text

Knosp CA, Schiering C, Spence S, Carroll HP, Nel HJ, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald DC, Powrie F, Fallon PG, Johnston JA, Kissenpfennig A., Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2., J. Immunol., 190, 2013, p3235 - 3245 Journal Article, 2013 DOI TARA - Full Text

Russell SE, Stefanska AM, Kubica M, Horan RM, Mantovani A, Garlanda C, Fallon PG, Walsh PT, Toll IL-1R8/Single Ig IL-1-Related Receptor Regulates Psoriasiform Inflammation through Direct Inhibition of Innate IL-17A Expression by "" T Cells., Journal of immunology (Baltimore, Md. : 1950), 191, (6), 2013, p3337-3346 Journal Article, 2013 DOI TARA - Full Text

Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT., Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways., Proc Natl Acad Sci U S A, 110, 2013, p18490 - 18495 Journal Article, 2013 DOI TARA - Full Text

Saunders, S.P., Goh, C.S.M., Brown, S.J., Palmer, C.N.A., Porter, R.M., Cole, C., Campbell, L.E., Gierlinski, M., Barton, G.J., Schneider, G., Balmain, A., Prescott, A.R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y.-A., Tavendale, R., Mukhopadhyay, S., Turner, S.W., Madhok, V.B., Sullivan, F.M., Relton, C., Burn, J., Meggitt, S., Smith, C.H., Allen, M.A., Barker, J.N.W.N., Reynolds, N.J., Cordell, H.J., Irvine, A.D., McLean, W.H.I., Sandilands, A., Fallon, P.G., Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects, Journal of Allergy and Clinical Immunology, 132, (5), 2013, p1121-1129 Journal Article, 2013 DOI TARA - Full Text

Yang S, Wang B, Humphries F, Jackson R, Healy M, Bergin R, Aviello G, Hall B, McNamara D, Walsh P, Russell S, Hussey S, O'Sullivan M, Darby T, Quinlan A, Shanahan F, Melgar S,Fallon PG, Moynagh P, Pellino3 ubiquitinates RIP2 and mediates NOD2-induced signaling and protective effects in colitis, Nature Immunology, 14, (9), 2013, p927 - 936 Journal Article, 2013 TARA - Full Text DOI

Young A, Linehan E, Hams E, O'Hara Hall AC, McClurg A, Johnston JA, Hunter CA, Fallon PG, Fitzgerald DC., Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27., J. Immunol., 186, 2012, p2079 - 2083 Journal Article, 2012 DOI

Bowie RV, Donatello S, Lyes C, Owens MB, Babina IS, Hudson L, Walsh SV, O'Donoghue DP, Amu S, Barry SP, Fallon PG, Hopkins AM., Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier., Am J Physiol Gastrointest Liver Physiol., 302, 2012, p781 - 791 Journal Article, 2012 DOI

Hams E, Fallon PG., Innate type 2 cells and asthma. , Curr. Opin. Pharmacol., 12, 2012, p503 - 509 Review Article, 2012 DOI

Viejo-Borbolla A, Martinez-Martín N, Nel HJ, Rueda P, Martín R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcamí A., Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses., PLoS Pathogens, 8, (2), 2012, pFeb;8(2):e1002497 Journal Article, 2012

Verma NK, Dempsey E, Long A, Davies A, Barry SP, Fallon PG, Volkov Y, Kelleher D, Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-ß signaling., The Journal of biological chemistry, 287, (32), 2012, p27204-16 Journal Article, 2012 DOI

Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P., Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice., PloS Pathog, 8, 2012, p1002883 Journal Article, 2012 DOI

Russell SE, Moore AC, Fallon PG, Walsh PT, Soluble IL-2R" (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice., PloS one, 7, (10), 2012, pe47748 Journal Article, 2012 TARA - Full Text DOI

Wong SH, Walker JA, Jolin HE, Drynan LF, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, McKenzie AN., Transcription factor RORα is critical for nuocyte development., Nature Immunology, 13, 2012, p229 - 236 Journal Article, 2012 DOI

Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD., The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses., Science, 335, 2012, p984 - 989 Journal Article, 2012 DOI

Kezic S, O'Regan GM, Lutter R, Jakasa I, Koster ES, Saunders S, Caspers P, Kemperman PM, Puppels GJ, Sandilands A, Chen H, Campbell LE, Kroboth K, Watson R, Fallon PG, McLean WH, Irvine AD, Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency., The Journal of allergy and clinical immunology, 129, (4), 2012, p1031-9.e1 Journal Article, 2012 DOI TARA - Full Text

Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN., Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia., Nat Commun, 3, 2012, p1119 Journal Article, 2012 DOI

Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H, Kubota Y., Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies., Am. J. Path., 181, 2012, p969 - 977 Journal Article, 2012 DOI

Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN., The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α., J Biol Chem., 287, 2012, p25440 - 25553 Journal Article, 2012 DOI

Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy, Jennifer K. Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J. O'Connell, Brian Keogh, Charles O. Morton, Thomas R. Rogers, Padraic G. Fallon, Luke A. O'Neill, Dermot Kelleher, Christine E. Loscher , A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins, PLoS Pathogens, 7, (6, e1002076), 2011 Journal Article, 2011 TARA - Full Text

Knosp CA, Carroll HP, Elliott J, Saunders SP, Nel HJ, Amu S, Pratt JC, Spence S, Doran E, Cooke N, Jackson R, Swift J, Fitzgerald DC, Heaney LG, Fallon PG, Kissenpfennig A, Johnston JA., SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses., Journal of Experimental Medicine, 208, (7), 2011, p1523-1531 Journal Article, 2011 TARA - Full Text

Miajlovic H, Fallon PG, Irvine AD, Foster TJ., Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus, Journal of Allergy and Clinical Immunology, 126, (6), 2011, p1184-1190 Journal Article, 2011 TARA - Full Text DOI

Enoksson M, Lyberg K, Möller-Westerberg C, Fallon PG, Nilsson G, Lunderius-Andersson C., Mast Cells as Sensors of Cell Injury through IL-33 Recognition., Journal of Immunology, 186, (4), 2011, p2523-2528 Journal Article, 2011 DOI

Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O'Connor A, Gallagher WM, Lenihan CR, Garvey JF, Howell K, Fallon PG, Cummins EP, Taylor CT., An intact canonical NF-?B pathway is required for inflammatory gene expression in response to hypoxia., Journal of Immunology, 186, (2), 2011, p1091-1096 Journal Article, 2011 DOI

Emily Hams, Mark J. McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen and Padraic G. Fallon, Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells , The Journal of Immunology, 186, (10), 2011, p5648-5655 Journal Article, 2011 TARA - Full Text URL

Downer EJ, Clifford E, Gran B, Nel HJ, Fallon PG, Moynagh PN , Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis., The Journal of Biological Chemistry, 286, (12), 2011, p10316-10328 Journal Article, 2011 TARA - Full Text

Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207 Journal Article, 2011 TARA - Full Text

Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG. , Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. , Journal of Immunology, 186, (8), 2011, p4631-4639 Journal Article, 2011 TARA - Full Text URL

Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne AT, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG ., The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells., Shock, 36, (3), 2011, p295-302 Journal Article, 2011 TARA - Full Text

Murtaza M. Tambuwala, Eoin P. Cummins, Colin R. Lenihan, Judith Kiss, Markus Stauch, Carsten C. Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P. Saunders, Patrick H. Maxwell, Peter Carmeliet, Padraic G. Fallon, Martin Schneider, Cormac T. Taylor, Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function, Gastroenterology, 139, (6), 2010, p2093-2101 Journal Article, 2010 TARA - Full Text

Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN., Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity., Nature, 464, 2010, p1367 - 1310 Journal Article, 2010 DOI TARA - Full Text

Saunders SP, Barlow JL, Walsh CM, Bellsoi A, Smith P, McKenzie AN, Fallon PG., C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide., Journal Immunology, 184, (5), 2010, p2627 - 2637 Journal Article, 2010 DOI

Alexander Ludwig, Grant P. Otto, Kirsi Riento, Emily Hams, Padraic G. Fallon, and Ben J. Nichols, Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment, Journal of Cell Biology, 191, (4), 2010, p771-781 Journal Article, 2010 TARA - Full Text

Court N, Vasseur V, Vacher R, Frémond C, Shebzukhov Y, Yeremeev VV, Maillet I, Nedospasov SA, Gordon S, Fallon PG, Suzuki H, Ryffel B, Quesniaux VF., Partial Redundancy of the Pattern Recognition Receptors, Scavenger Receptors, and C-Type Lectins for the Long-TermControl of Mycobacterium tuberculosis Infection., Journal of Immunology, 184, 2010, p7057 -7070 Journal Article, 2010 DOI

Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG., Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model., Journal of Allergy and Clinical Immunology, 125, (5), 2010, p1114 - 1124 Journal Article, 2010 TARA - Full Text

Pathogen-derived immunomodulatory molecules. Preface. in, editor(s)Fallon, P.G. , Pathogen-derived immunomodulatory molecules. , USA, Landes Bioscience, 2009, [Fallon, P.G.] Book Chapter, 2009

Smith P, Mangan NE, Fallon PG., Generation of parasite antigens for use in Toll-like receptor research., Methods Molecular Biology, 517, 2009, p401 - 413 Journal Article, 2009 DOI

Ruiz Marquez JF, Radics G, Windle H, Serra HO, Simplicio AL, Kedziora K, Fallon PG, Kelleher DP, Gilmer GF, Design, Synthesis, and Pharmacological Effects of a Cyclization-activated Steroid Prodrug for Colon Targeting in Inflammatory Bowel Disease, Journal of Medicinal Chemistry, 52, (10), 2009, p3205 - 3211 Journal Article, 2009 DOI

Fallon, PG, Sasaki, T, Sandilands, A, Campbell, LE, Saunders, SP, Mangan, NE, Callanan, JJ, Kawasaki, H, Shiohama, A, Kubo, A, Sundberg, JP, Presland, RB, Fleckman, P, Shimizu, N, Kudoh, J, Irvine, AD, Amagai, M, McLean, WH, A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming., Nature Genetics, 41, (5), 2009, p602 - 608 Journal Article, 2009 DOI

Saunders SP, Walsh CM, Barlow JL, Mangan NE, Taylor PR, McKenzie AN, Smith P, Fallon PG, The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection, Infection and Immunity, 77, (1), 2009, p399 - 404 Journal Article, 2009 DOI TARA - Full Text

Adisakwattana P, Saunders SP, Nel HJ, Fallon PG., Helminth-derived immunomodulatory molecules., by Adisakwattana P, Saunders SP, Nel HJ, Fallon PG. , Advances in experimental medicine and biology , 666, 2009, p95-107 Review, 2009 DOI

Alison E. Adams, Orla Hanrahan, Derek N. Nolan, H. Paul Voorheis, Padraic Fallon and Richard K. Porter, Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy , Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777, (2), 2008, p115 - 117 Journal Article, 2008 DOI TARA - Full Text

Fallon PG, Why does work on same mouse models give different results?, Nature, 454, (7205), 2008, p691 - 691 Journal Article, 2008 DOI

Cummins EP, Seeballuck F, Keely SJ, Mangan NE, Callanan JJ, Fallon PG, Taylor CT, The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis, Gastroenterology, 134, (1), 2008, p156 - 165 Journal Article, 2008 DOI

Adams AE, Carroll AM, Fallon PG, Porter RK., Mitochondrial uncoupling protein 1 expression in thymocytes., Biochimica et Biophysica Acta (BBA) - Bioenergetics , 1777, (7-8), 2008, p772 - 776 Journal Article, 2008 TARA - Full Text DOI

Walsh, C.M, Smith, P., & Fallon, P.G. , Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice. , Parasite Immunology, 29, (6), 2007, p293 - 308 Journal Article, 2007 DOI

Feighery LM, Smith P, O'Mahony L, Fallon PG, Brayden DJ., Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease., Digestive Diseases and Sciences, 53, (9), 2007, p2495 - 2506 Journal Article, 2007 DOI

Moens L, Jeurissen A, Wuyts G, Fallon PG, Louis B, Ceuppens JL, Bossuyt X, Specific intracellular adhesion molecule-grabbing nonintegrin R1 is not involved in the murine antibody response to pneumococcal polysaccharides., Infection and Immunity, 75, (12), 2007, p2495 - 2506 Journal Article, 2007 DOI TARA - Full Text

Walsh CM, Smith P, Fallon PG., Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice, Parasite Immunology, 29, (6), 2007, p293 - 308 Journal Article, 2007 DOI

Smith, P., Mangan, N.E., Walsh, C.M, Fallon, R.E., van Rooijen, N., McKenzie, & Fallon, P.G. , Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. , Journal of Immunology , 178, (7), 2007, p4557 - 4566 Journal Article, 2007 URL

Mangan, N.E., Dasvarma, A., McKenzie, A.N. & Fallon, P.G. , T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. , European Journal of Immunology , 37, (5), 2007, p1302 - 1312 Journal Article, 2007 DOI

Fallon, P.G., Mangan, N.E., Suppression of TH2-type allergic inflammation by helminth infection., Nature Reviews in Immunology, 7, 2007, p220 - 230 Journal Article, 2007 DOI

Fallon PG, Ballantyne SJ, Mangan NE, Barlow JL, Dasvarma A, Hewett DR, McIlgorm A, Jolin HE, McKenzie AN., Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion., The Journal of Experimental Medicine, 203, (4), 2006, p1105 - 1116 Journal Article, 2006 DOI TARA - Full Text

Mangan, N.E., Rooijen, N. McKenzie, A.N.J. & Fallon, P.G. , Helminth-modified pulmonary response protects mice from allergen-induced airway hyper-responsiveness. , The Journal of Immunology, 176, 2006, p138 - 147 Journal Article, 2006 URL

Fallon, P.G., Alcami. A., Pathogen-dervied immunomodulatory molecules: future immunotherapeutics?, Trends in Immunology, 27, (10), 2006, p470 - 476 Journal Article, 2006 DOI

Hewett, D.R., Simons, A.L., Mangan, N.E., Jolin, H.E., Green, S.M., Fallon, P.G. & McKenzie, A.N.J., Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome, Human Molecular Genetics, 14, (2), 2005, p335 - 346 Journal Article, 2005 DOI TARA - Full Text

Carroll, A.M., Haines, L.R., Pearson, T.W., Fallon, P.G., Walsh, C.M., Brennan, C., Breen, E. & Porter, R.K., Identification of a functioning mitochondrial uncoupling protein 1 in thymus, Journal of Biological Chemistry, 280, 2005, p155534 - 155543 Journal Article, 2005 TARA - Full Text DOI

Smith, P., Fallon, R.E., Mangan, N.E., Walsh, C.M., Saraiva, M., Sayers, J.R., McKenzie, A.N., Alcami, A. & Fallon P.G. , Schistosoma mansoni secretes a chemokine binding protein with anti-inflammatory activity. , Journal of Experimental Medicine , 202, (10), 2005, p1319 - 1325 Journal Article, 2005 DOI

Mangan, N.E., Fallon, R.E., Smith, P., Rooijen, N. McKenzie, A.N.J. & Fallon, P.G., Helminth infection protects mice from anaphylaxis via IL-10 producing B cells, Journal of Immunology, 173, 2004, p6346 - 6356 Journal Article, 2004 TARA - Full Text

Lanoue, A., Clatworthy, M.R., Smith, P. Green, S., Townsend, M.J., Jolin, H.E., Smith, K.G.S., Fallon, P.G. & McKenzie, A.N.J., SIGN-R1 contributes to protection against lethal pneumococcal infection in mice, Journal of Experimental Medicine, 200, (11), 2004, p1383 - 1393 Journal Article, 2004 TARA - Full Text DOI

Lauder, A.J., Jolin, H.E., Smith, P., van den Berg, J.G., Jones, A., Wisden, W., Smith. K., Dasvarma, A., Fallon, P.G. & McKenzie, A.N.J., Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines, Journal of Immunology, 173, 2004, p113 - 122 Journal Article, 2004 TARA - Full Text

Bogers, J. P., Chatterjee, S., Jacobs, W., Fallon, P.G., Dunne, D.W., Langermans, J.A.M., Deelder, A., Thomas, A.W. & van Marck. E., Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni, Virchows Archiv, 445, 2004, p285 - 291 Journal Article, 2004

Smith, P., Walsh, C.M, Mangan, N.E., Fallon, R.E., Sayers, J.R., McKenzie, A.N. & Fallon, P.G., Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages, Journal of Immunology, 173, (2), 2004, p1240 - 1248 Journal Article, 2004 TARA - Full Text

Achatz-Straussberger, G., Geisberger, R., Oberndorfer, I., Infuhr, D., Luger, E., Fallon, P., Lamers, M. & Achatz, G., Construction of a sIgE:FLAG-mIgE:GFP reporter mouse strain, International Archives of Allergy and Immunology, 130, (4), 2003, p280 - 287 Journal Article, 2003 DOI

Jarnicki, A.G. & Fallon, P.G., T helper type-2 cytokine responses: potential therapeutic targets, Current Opinion in Pharmacology, 3, (4), 2003, p449 - 455 Journal Article, 2003 DOI

Fallon, P.G., Gibbons, J., Vervenne, R.A., Richardson, E.J., Fulford, A.J., Sturrock, R.F., Coulson, P.S. Deelder, A.M., Langermans, J.A.M., Thomas, A.W. & Dunne, D.W., Juvenile Rhesus monkeys have lower type 2 cytokine responses than adults following primary infection with Schistosoma mansoni, Journal of Infectious Diseases, 187, 2003, p939 - 945 Journal Article, 2003 DOI

McKenzie, A.N.J. and Fallon, P.G., Decoy receptors in the regulation of T Helper cell type 2 response, Journal of Experimental Medicine, 197, (6), 2003, p675 - 679 Journal Article, 2003 TARA - Full Text DOI

Fallon, P.G., Jolin, H.E., Smith, P., Emson, C.L., Townsend, M.J., Fallon, R., Smith, P. & McKenzie, A.N.J., IL-4 induces characteristic Th2 response even in the combined absence of IL-5, IL-9 and IL-13, Immunity, 17, (1), 2002, p7 - 17 Journal Article, 2002 DOI

Buendia, A.J., Fallon, P.G., Del Rio, L., Ortega, N., Caro, M.R., Gallego, M.C. & Salinas, J., Previous infection with the nematode Nippostrongylus brasiliensis alters the immune specific response against Chlamydophila abortus infection, Microbial Pathogenesis, 33, (1), 2002, p7 - 15 Journal Article, 2002 DOI

Cunningham, A.F., Fallon, P.G., Khan, M., Vacheron, S., Acha-Orbea, H., MacLennan, I.C.M., McKenzie, A. & Toellmer, K-M., Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13 and B cells, Journal of Immunology, 169, 2002, p2900 - 2906 Journal Article, 2002 URL

Saraiva, M., Smith, P., Fallon, P.G. and Alcami, A., Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus, Journal of Experimental Medicine, 196, (6), 2002, p829 - 839 Journal Article, 2002 DOI

Brint, E.K., Fitzgerald, K.A., Smith, P., Coyle, A.J., Gutierrez-Ramos, J-C., Fallon, P.G. & O'Neill, L.A.J., Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction, Journal of Biological Chemistry, 277, (51), 2002, p49205 - 49211 Journal Article, 2002 DOI TARA - Full Text

Fallon, P.G., Allen, R.L. & Rich, T., Primitive Toll signaling: bugs, flies, worms and man, Tends in Immunology, 22, (2), 2001, p63 - 66 Journal Article, 2001 DOI

Smith, P., Dunne, D.W. & Fallon, P.G., Defective in vivo induction of functional type 2 cytokine responses in aged mice, European Journal of Immunology, 31, (5), 2001, p1495 - 1502 Journal Article, 2001 DOI

Fallon, P.G., Emson, C.L., Smith, P. & McKenzie, A.N.J., Interleukin-13 overexpression predisposes to anaphylaxis following antigen sensitization, Journal of Immunology, 166, (4), 2001, p2712 - 2716 Journal Article, 2001 URL

Fallon, P.G., Smith, P, Richardson, E.J., Jones, F.M., Faulkner, H.C., Van Snick, J., Renauld, J-C, Grencis, R.K. &, Dunne, D.W., Expression of Interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections, Infection and Immunity, 68, (10), 2000, p6005 - 6011 Journal Article, 2000 DOI

Fallon, P.G., Immunopathology of schistosomiasis: a cautionary tale of mice and men, Immunology Today, 21, (1), 2000, p29 - 35 Journal Article, 2000 DOI

Fallon, P.G., Richardson, E.J., McKenzie, G.J. & McKenzie, A.N.J., Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent, Journal of Immunology, 164, 2000, p2585 - 2591 Journal Article, 2000 URL

Townsend, M.J., Fallon, P.G., Matthews, D.J., Smith, P., Jolin, H.E. & McKenzie, A.N.J., IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development, Immunity, 13, (4), 2000, p573 - 583 Journal Article, 2000 DOI

Fallon, P.G., Richardson, E.J., Smith, P. & Dunne, D.W., Elevated type 1, diminished type 2 cytokines and impaired antibody responses are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice, European Journal of Immunology, 30, (2), 2000, p470 - 480 Journal Article, 2000 DOI

Townsend, M.J., Fallon, P.G., Matthews, D.J., Jolin, H.E. & McKenzie, A.N.J., T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary Th2 responses to immunization, Journal of Experimental Medicine, 191, (6), 2000, p1069 - 1075 Journal Article, 2000 DOI

McKenzie, G.J., Fallon, P.G., Emson, C.L., Grencis, R.K. & McKenzie, A.N.J., Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T Helper cell Type 2-mediated responses, Journal of Experimental Medicine, 189, 1999, p1565 - 1572 Journal Article, 1999

Fallon, P.G. & Dunne, D.W., Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection, Journal of Immunology, 162, 1999, p4122 - 4132 Journal Article, 1999 URL

Hamilton, J.V., Chiodini, P.L., Fallon, P.G. & Doenhoff, M.J., Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens, Parasitology, 118, 1999, p83 - 89 Journal Article, 1999 DOI

Fallon, P.G., Schistosome resistance to praziquantel, Drug Resistance Updates, 1, (4), 1998, p236 - 241 Journal Article, 1998 DOI

Fallon, P.G., Smith, P. & Dunne, D.W., Type 1 and Type 2 cytokine- producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection, European Journal of Immunology, 28, (4), 1998, p1408 - 1416 Journal Article, 1998 DOI

Pereira, C., Fallon, P.G., Cornette, J., Capron, A., Doenhoff, M.J. & Pierce, R.J., Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni., Parasitology, 117, (1), 1998, p63 - 73 Journal Article, 1998

McKenzie, G.J., Emson, C.L., Bell, S.E., Fallon, P.G., Krishna, M., Zurawski, G., Murray, R. Grencis, R. & McKenzie, A.N.J., Impaired development of Th2 cells in IL-13-deficient mice, Immunity, 9, (3), 1998, p423 - 432 Journal Article, 1998 DOI

Fallon, P.G., Richardson, E.J., Jones, F.M. & Dunne, D.W., Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni, Clinical and Diagnostic Laboratory Immunology, 5, (2), 1998, p251 - 253 Journal Article, 1998 URL

Fallon, P.G., Mubarak, J., Fookes, R.E., Sturrock, R.F., Butterworth, A.E., Niang, M. & Doenhoff, M.J., Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates., Experimental Parasitology, 86, (1), 1997, p29 - 36 Journal Article, 1997 DOI

Webster, M., Fulford, A.J.C., Fallon, P.G., Butterworth, A.E., Ouma, J.H., Kimani, G. & Dunne, D.W., Effect of Praziquantel or Oxamniquine on human isotype responses to Schistosoma mansoni: elevated IgE to adult worm, Parasite Immunology, 19, (7), 1997, p333 - 335 Journal Article, 1997 DOI

Webster, M., Fallon, P.G., Fulford, A.J.C., Butterworth, A.E., Ouma, J.H., Kimani, G. & Dunne, D.W., IgG4 and IgE responses to Schistosoma mansoni adult worms after treatment, Journal of Infectious Diseases, 175, 1997, p493 - 494 Journal Article, 1997

Millership, J., Chappell, L.H. & Fallon, P.G., Synergistic action of Cyclosporin A and polyspecific rabbit anti-sera against murine Schistosoma mansoni, Parasite Immunology, 18, (2), 1996, p71 - 77 Journal Article, 1996 DOI

Redman, C.A., Robertson, A., Fallon, P.G., Modha, J., Kusel, J.R., Doenhoff, M.J. & Martin, R.J., Praziquantel, an urgent and exciting challenge, Parasitology Today, 12, (1), 1996, p14 - 20 Journal Article, 1996 DOI

Sayers, J.R., Price, H.P., Fallon, P.G. & Doenhoff, M.J., AGA/AGG codon usage in parasites: reply, Parasitology Today, 12, 1996, p124 - 125 Journal Article, 1996

Fallon, P.G., Fookes, R.E. & Doenhoff, M.J., Protection of mice against Schistosoma mansoni infection by passive transfer of sera from infected rabbits, Parasite Immunology, 18, (1), 1996, p7 - 14 Journal Article, 1996 DOI

Fallon, P.G., Teixeria, M.M., McNeice, C., Williams, T.J., Hellewell, P.G. & Doenhoff, M.J., Enhancement of Schistosoma mansoni infectivity by intradermal injections of larval extracts: A putative role for larval protease's, Journal of Infectious Diseases, 173, (6), 1996, p1460 - 1466 Journal Article, 1996 URL

Curtis, R.H.C., Fallon, P.G. & Doenhoff, M.J., Sm480: a high molecular weight Schistosoma mansoni antigen associated with protection, Parasite Immunology, 18, 1996, p149 - 157 Journal Article, 1996 DOI

Fallon, P.G., Warren, J. & Behnke, J.M., Evaluation of immune dependence of anthelmintic treatment of Heligmosomoides polygyrus in CBA/Ca mice, International Journal for Parasitology, 26, (5), 1996, p557 - 560 Journal Article, 1996 DOI

Fallon, P.G. & Hagan, P., Blood and Guts at Bangor, Parasitology Today, 12, (12), 1996, p460 - 462 Journal Article, 1996 DOI

Fallon, P.G., Tao, L-F., Ismail, M.M. & Bennett, J.M., Schistosome resistance to praziquantel: fact or artifact, Parasitology Today, 12, (8), 1996, p316 - 320 Journal Article, 1996 DOI

Fallon, P.G., Fookes, R.E. & Wharton, G., Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: implications for drug-antibody synergy, Parasitology, 112, 1996, p47 - 58 Journal Article, 1996 DOI

Sayers, J.R., Price, H.P., Fallon, P.G. & Doenhoff, M.J., AGA/AGG codon usage in parasites: implications for gene expression in Escherichia coli, Parasitology Today, 11, (9), 1995, p345 - 346 Journal Article, 1995 DOI

Fallon, P.G. & Doenhoff, M.J., Active immunization of mice with Schistosoma mansoni worm membrane antigens enhances efficacy of praziquantel, Parasite Immunology, 17, (5), 1995, p261 - 268 Journal Article, 1995 DOI

Fallon, P.G., Hamilton, J.V. & Doenhoff, M.J., Efficacy of treatment of murine Schistosoma mansoni infections with praziquantel and oxamniquine correlates with infection intensity: role of host antibody, Parasitology, 111, (1), 1995, p59 - 66 Journal Article, 1995 DOI

Fallon, P.G., Sturrock, R.F., Capron, A., Niang, M. & Doenhoff, M.J., Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni, American Journal of Tropical Medicine and Hygiene, 53, (1), 1995, p61 - 62 Journal Article, 1995 URL

Fallon, P.G., McNeice, C., Probert, A.J. & Doenhoff, M.J., Quantification of praziquantel-induced damage on the surface of adult Schistosoma mansoni worms: estimation of esterase and alkaline phosphatase activity, Parasitology Research, 80, (7), 1994, p623 - 625 Journal Article, 1994 DOI

Fallon, P.G. & Doenhoff, M.J., Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific, American Journal of Tropical Medicine and Hygiene, 51, (1), 1994, p83 - 88 Journal Article, 1994 URL

Fallon, P.G., Smith, P., Nichols, T., Modha, J. & Doenhoff, M.J., Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase: drug-antibody synergy which acts preferentially against female worms, Parasite Immunology, 16, (10), 1994, p529 - 535 Journal Article, 1994 DOI

Badawi, A.F., Cooper, D.P., Mostafa, M.H., Doenhoff, M.J., Probert, A., Fallon, P.G., Cooper, R, & O'Connor, P.J., Promutagenic methylation damage in liver DNA of mice infected with Schistosoma mansoni, Carcinogenesis, 14, (4), 1993, p653 - 657 Journal Article, 1993 URL

Fallon, P.G., Cooper, R.O., Probert, A.J. & Doenhoff, M.J., Immune-dependent chemotherapy of schistosomiasis, Parasitology, 105, 1992, pS41 - S48 Journal Article, 1992 DOI

Research Expertise

Description

My research involves two overlapping translational immunology themes. i. The use of mouse models to study pathogen modulation of human inflammatory diseases. ii. Immune phenotyping of patients, in particular children, with inflammatory diseases such as atopic dermatitis and pulmonary fibrosis. Research aims to elucidate new mechanism of modulation of immunity that can alter inflammation and have therapeutic potential. Collaborative activity involves the phenotyping of new transgenic mice. The main diseases addressed are allergic lung and skin inflammation and inflammatory bowel disease. A growing emphasis is applying extensive expertise in animal models of human inflammatory diseases and general pathophysiology of inflammation to functional analysis of new therapeutic molecules/strategies with clinical collaborators and Pharma.

Keywords

Allergies; ALLERGY; Animal Models; ANIMAL-MODELS; Asthma; CYTOKINE RESPONSES; DISEASE MODELS; EXPERIMENTAL COLITIS; Helminths; Immunotherapies; INFECTION; Inflammatory Bowel Disease; MATERNAL-FETAL INTERFACE; Parasites; Transgenic Mice

Recognition

Awards and Honours

Member Royal Irish Academy (MRIA) 2014

Fellow Trinity College Dublin (FTCD) 2009

Stokes Professorship from Science Foundation Ireland. 2008