Dr. Oliviero Gobbo
Assistant Professor, Pharmacy
Publications and Further Research Outputs
Peer-Reviewed Publications
Gobbo O.L., Tackling obesity from a nanomedicine perspective, Review of Clinical Pharmacology and Pharmacokinetics, International Edition, 38, 2024, p15 - 17, p15-17
Mundzic M., Lazovic J., Mladenovic M., Pavlovic A., Ultimo A., Gobbo O.L., Ruiz-Hernandez E., Santos-Martinez M.J., Knezevic N.Z., MRI-based sensing of pH-responsive content release from mesoporous silica nanoparticles, Journal of Sol-Gel Science and Technology, 111, (1), 2024, p95 - 105, p95-105
Alanezi, S.T. and Almutairi, W.M. and Cronin, M. and Gobbo, O. and O'Mara, S.M. and Sheppard, D. and O'Connor, W.T. and Gilchrist, M.D. and Kleefeld, C. and Colgan, N., Whole-brain traumatic controlled cortical impact to the left frontal lobe: Magnetic resonance image-based texture analysis, Journal of Neuropathology and Experimental Neurology, 83, (2), 2024, p94-106
LCS Erthal, Y Shi, KJ Sweeney, OL Gobbo, E Ruiz-Hernandez, Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme, Scientific Reports, 13, (1), 2023, p5094-
Hannon, G. and Bogdanska, A. and Keogh, A. and Finn, S.P. and Gobbo, O.L. and Prina-Mello, A., Biodistribution and histological analysis of iron oxide-dextran nanoparticles in wistar rats, Nanotoxicology, 17, (8-9), 2023, p562-580
Fernandez, Y. and Movellan, J. and Foradada, L. and Gimenez, V. and Garcia-Aranda, N. and Mancilla, S. and Arminan, A. and Borgos, S.E. and Hyldbakk, A. and Bogdanska, A. and Gobbo, O.L. and Prina-Mello, A. and Ponti, J. and Calzolai, L. and Zagorodko, O. and Gallon, E. and Nino-Pariente, A. and Paul, A. and Schwartz Jr, S. and Abasolo, I. and Vicent, M.J., In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy, Advanced Healthcare Materials, 11, (7), 2022
Stavropoulou A.P., Theodosiou M., Sakellis E., Boukos N., Papanastasiou G., Wang C., Tavares A., Corral C.A., Gournis D., Chalmpes N., Gobbo O.L., Efthimiadou E.K., Bimetallic gold-platinum nanoparticles as a drug delivery system coated with a new drug to target glioblastoma, Colloids and Surfaces B: Biointerfaces, 214, 2022
Lynch M.J., Gobbo O.L., Advances in non-animal testing approaches towards accelerated clinical translation of novel nanotheranostic therapeutics for central nervous system disorders, Nanomaterials, 11, (10), 2021
Erthal LCS, Gobbo OL, Ruiz-Hernandez E, Biocompatible copolymer formulations to treat glioblastoma multiforme., Acta Biomaterialia, 121, (February 2021), 2021, p89 - 102
Bogdanska, A. and Gobbo, O.L. and Volkov, Y. and Prina-Mello, A., 3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment, Nanotoxicology, 15, (9), 2021, p1151-1167
GA Oluniran, M Cronin, O Gobbo, S O'mara, W O'Connor, N Colgan, M Gilchrist. Apparent diffusion changes in traumatic brain injury model following controlled cortical impact(ed.), European Society of Radiology, Insights into Imaging, Vienna, 10, 27 Feb-3 Mar 2019, 2019
Spirou SV, Costa Lima SA, Bouziotis P, Vranje -Djurić S, Efthimiadou EΚ, Laurenzana A, Barbosa A, Garcia-Alonso I, Jones C, Jankovic D, Gobbo OL., Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy., Nanomaterials (Basel). , 8(5), 2018, p10.3390/nano8050306
Oliviero L Gobbo, Aislinn Mc Phillips, Tara Hamilton, Jerrard Hayes, Gavin Davey, Assessment of Intravenous Immunoglobulin treatment on BBB function following inflammation, ISMRM, Paris, 2018, edited by ISMRM , 2018
Bianchi, A., Gobbo, O.L., Dufort, S., Sancey, L., Lux, F., Tillement, O., Coll, J.-L., Crémillieux, Y., Orotracheal manganese-enhanced MRI (MEMRI): An effective approach for lung tumor detection, NMR in Biomedicine, 2017
Edge, D., Shortt, C.M., Johns, E.J., Gobbo, O.L., Markos, F., Abdulla, M.H., Barry, E.F., Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles, Canadian Journal of Physiology and Pharmacology, 95, (4), 2017, p443-446
Tewes, F, Gobbo, OL, Ehrhardt, C, Healy, AM, Amorphous calcium carbonate based-microparticles for peptide pulmonary delivery, ACS Applied materials and interfaces, 8, (2), 2016, p1164-1175
Edge D, Shortt CM, Gobbo OL, Teughels S, Prina-Mello A, Volkov Y, MacEneaney P, Radomski MW, Markos F, Pharmacokinetics and bio-distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig., Clinical and experimental pharmacology & physiology, 43, (3), 2016, p319-326
Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203
Gobbo, O.L., Sjaastad, K., Radomski, M.W., Volkov, Y., Prina-Mello, A, Magnetic nanoparticles in cancer theranostics, Theranostics, 5, 2015, p1249 - 1263
Gobbo, O.L., Wetterling, F., Vaes, P., Teughels, S., Markos, F., Edge, D., Shortt, C. M., Crosbie-Staunton, K., Radomski, M.W., Volkov, Y., Prina-Mello, A, Biodistribution and pharmacokinetic studies of SPION using particle Electron Paramagnetic Resonance, MRI and ICP-MS, Nanomedicine (Lond.), 10, 2015, p1751 - 1760
Amaro MI, Tewes F, Gobbo O, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation, International Journal of Pharmaceutics, 483, (1-2), 2015, p6-18
Oliviero L Gobbo, Andrew J Fagan, Colin Ryan, Deirdre Edge, Christine Shortt, Marek Radomski, Adriele Prina-Mello, Farouk Markos, Yuri Volkov, Quantification of Iron Oxide Nanoparticles in a large animal model using MRI, Proc. Intl. Soc. Mag. Reson. Med, ISMRM, Milan, 2014, 22, 2014, pp2214-
Mansergh FC, Chadderton N, Kenna PF, Gobbo OL, Farrar GJ, Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy, European Journal of Human Genetics, 22, (11), 2014, p1314-20
Shortt, Christine, Edge, Deirdre, Teughels, Stephanie, Roskin, Eric, Verbiest, Joeri, Gobbo, Oliviero, Prina"Mello, Adriele, Volkov, Yuri, Markos, Farouk, Bio"distribution of superparagmetic iron oxide nanoparticles (SPION"s) in the pig (LB578), The FASEB Journal, 28, (S1), 2014
Swaminathan J, Gobbo OL, Tewes F, Healy AM, Ehrhardt C, Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27, (1), 2014, p1-11
N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, M Carrigan, M O'Reilly, M Campbell, C Ehrhardt, U Wolfrum, P Humphries, PF Kenna, GJ Farrar, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy, Eur J Hum Genet, 21, (1), 2013, p62-68
Rouine J, Gobbo OL, Campbell M, Gigliucci V, Ogden I, McHugh Smith K, Duffy P, Behan B, Byrne D, Kelly ME, Blau CW, Kerskens CM, Harkin A, MDMA 'ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI., British journal of pharmacology, 169, (5), 2013, p974-87
MM Gaspar, A Radomska, OL Gobbo, MW Radomski, C Ehrhardt, Targeted delivery of transferrin-conjugated liposomes to an orthotopic model of lung cancer in nude rats, J Aerosol Med Pulm Drug Deliv, 25, (6), 2012, p310-318
Hanrahan F, Campbell M, Nguyen AT, Suzuki M, Kiang AS, Tam LC, Gobbo OL, Dhubhghaill SN, Humphries MM, Kenna PF, Humphries P, On further development of barrier modulation as a technique for systemic ocular drug delivery., Advances in experimental medicine and biology, 723, 2012, p155-9
OL Gobbo, M Zurek, F Tewes, C Ehrhardt, Y Crémillieux, Manganese: a new contrast agent for lung imaging?, Contrast Media Mol I, 7, (6), 2012, p542-546
Gobbo, O.L., Petit, F., Gurden, H., Dhenain, M., In vivo detection of excitotoxicity by manganese- enhanced MRI: Comparison with physiological stimulation, Magnetic Resonance in Medicine, 68, (1), 2012, p234-240
Campbell M, Hanrahan F, Gobbo OL, Kelly ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW, Kerskens CM, Cahalan SD, Callanan JJ, Wallace E, Grant GA, Doherty CP, Humphries P, Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury., Nature communications, 3, 2012, p849
Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C, In vitro and in vivo characterisation of PEG-lipid based micellar complexes of salmon calcitonin for pulmonary delivery, Pharm Res, 29, (6), 2012, p1425-1434
Lesburguères, E., Gobbo, O.L., Alaux-Cantin, S., Hambucken, A., Trifilieff, P., Bontempi, B., Early tagging of cortical networks is required for the formation of enduring associative memory, Science, 331, (6019), 2011, p924-928
Campbell M, Humphries MM, Nguyen ATH, Gobbo OL, Tam LCS, Suzuki M, Hanrahan F, Ozaki E, Farrar G-J, Kiang A-S, Kenna PF, Humphries P. , Systemic low-molecular weight drug delivery to pre-selected neuronal regions, EMBO Molecular Medicine, 3, (4), 2011, p235-245
Tewes F, Gobbo OL, Amaro MI, Tajber L, Corrigan OI, Ehrhardt C, Healy AM, Evaluation of HPβCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery, Molecular Pharmaceutics, 8, (5), 2011, p1887 - 1898
Dunleavy M, Shinoda S, Schindler C, Ewart C, Dolan R, Gobbo OL, Kerskens CM, Henshall DC, Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis., The American journal of pathology, 176, (1), 2010, p330-42
Michael E Kelly, Christoph W Blau, Karen M Griffin, Oliviero L Gobbo, James FX Jones and Christian M Kerskens, Quantitative functional magnetic resonance imaging of brain activity using bolus-tracking arterial spin labeling , Journal of Cerebral Blood Flow & Metabolism, 2010
MM Gaspar, O Gobbo, C Ehrhardt, Generation of liposome aerosols with the Aeroneb Pro and the AeroProbe nebulisers, J Liposome Res, 20, (1), 2010, p55-61
Gobbo, Oliviero L., Models of neurodegeneration in the hippocampus., Saarbrucken, Germany, LAP Lambert Academic Publishing, 2010
Colgan NC, Cronin MM, Gobbo OL, O'Mara SM, O'Connor WT, Gilchrist MD. , Quantitative MRI analysis of brain volume changes due to controlled cortical impact. , Journal of Neurotrauma, 27, (7), 2010, p1265-1274
O. Gobbo, M. Campbell, A.Kiang, P. Kenna, C. Kerskens, G. J. Farrar, P. Humphries, RNAi-MEDIATED REVERSIBLE OPENING OF THE BLOOD-BRAIN AND BLOODRETINA BARRIER, MRI Satellite Symposium, 2009
Friedrich Wetterling, Oliviero Gobbo, Martin Tabbert, Sven Junge, Andrew J Fagan Sodium MRI Using a Two-Element Phased Array Coil: A Quantification Accuracy Study(ed.), ISMRM, Proc. Intl. Soc. Mag. Reson. Med, Honolulu, 17, (3281), 2009, 2009
M. E. Kelly, C. W. Blau, O. L. Gobbo, K. M. Griffin, J. F. Jones, and C. M. Kerskens, Functional bolus-tracking arterial spin labeling; a new approach to quantitative fMRI , International Society for Magnetic Resonance in Medicine, 17th scientific meeting and exhibition, 2009
Matthew Campbell, Anh T. H. Nguyen, Anna-Sophia Kiang, Lawrence C. S. Tam, Oliviero L. Gobbo, Christian Kerskens, Sorcha Ni Dhubhghaill, Marian M. Humphries, G.-Jane Farrar, Paul F. Kenna and Peter Humphries, An experimental platform for systemic drug delivery to the retina, Proceedings of the National Academy of Sciences of the United States, 106, (42), 2009, p17817 - 17822
M.E. Kelly, C.W. Blau, O.L. Gobbo, K.M. Griffin, J.FX. Jones, C.M. Kerskens, QUANTITATIVE FUNCTIONAL MAGNETIC RESONANCE IMAGING WITH BOLUSTRACKING ARTERIAL SPIN LABELLING, MRI Satellite Symposium, 2009
Wetterling, Friedrich; Gobbo, Oliviero; Tabbert, Martin; Junge, Sven; Fagan, Andrew, A Variable Inductively Coupled Two-Element Phased Array Coil for Rat Brain Na-MRI at 7T., MAGMA Magnetic Resonance Materials in Physics Biology and Medicine., 21.30, 2008
Larkin AE, Fahey B, Gobbo O, Callaghan CK, Cahill E, O'Mara SM, Kelly ÁM., Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat, Brain Research, 1199, 2008, p126 - 132
Gobbo OL, O'Mara SM., Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor., Behav Brain Res, 159, (1), 2005, p21 - 26
Gobbo, O.L. & O'Mara, S.M., Combining exercise and cyclooxygenase-2 inhibition does not ameliorate learning deficits after brain insult, despite an increase in BDNF levels, Brain Research, 1046, 2005, p224 - 229
Gobbo OL, O'Mara SM, Impact of enriched-environment housing on brain-derived neurotrophic factor and on cognitive performance after a transient global ischemia, BEHAVIOURAL BRAIN RESEARCH, 152, 2, (JUL 9), 2004, p231 - 241
Gobbo OL, O'Mara SM, Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration, NEUROSCIENCE, 125 , (2), 2004, p317 - 327
O Piot-Grosjean, F Wahl, OGobbo, J Stutzmann, Assessment of sensorimotor and cognitive deficits induced by a moderate traumatic injury in the right parietal cortex of the rat., Neurobiology of disease, 8, (6), 2001, p1082 - 1093
Non-Peer-Reviewed Publications
N Chadderton, A Palfi, S Millington-Ward, O Gobbo, N Overlack, M Carrigan, M O'Reilly, M Campbell, C Ehrhardt, U Wolfrum, P Humphries, PF Kenna, GJ Farrar, Intravitreal delivery of AAV-NDI1 for the treatment of Leber Hereditary Optic Neuropathy, Hum Gene Ther, Retina 2011 - Fighting Blindness, Dublin, Ireland, 11-12/11/2011, 23, (10), 2012, ppA55-A56
F Tewes, M Zurek, C Ehrhardt, Y Crémillieux, OL Gobbo, Manganese: A new contrast agent for lung imaging?, AAPS J, 25th Annual Meeting of the AAPS, Washington, DC, 23-27/10/2011, 13, (S2), 2011, ppT2069
J Rouine, B Behan, M Kelly, C Blau, O Gobbo, C Kerskens, A Harkin, PERFUSION MAGNETIC RESONANCE IMAGING USING SPIN LABELLING OF ARTERIAL WATER SHOWS INCREASED CORTICAL BLOOD FLOW FOLLOWING METHYLENEDIOXY-METHAMPHETAMINE, 179, 2010, pS108 - S109
Hennigan A., Larkin A., Gobbo O., Fahej B., O'Mara S. M., Kelly A. M., Spatial learning in the rat is NMDA-receptor dependent: evidence from an object displacement task, Acta Neurobiologiae Experimentalis, 65, (5), 2005, p52-
Assunta Imperato, Saliha Moussaoui, Carmen Obinu, Oliviero Gobbo, 'NEW THERAPEUTIC APPLICATION OF P SUBSTANCE ANTAGONISTS', Aventis Pharma SA, 1996, 22 November 2024, Aventis Pharma SA
Research Expertise
Recognition
Awards and Honours
Trinity Boost Funding Programme (€20,000)
European Cooperation in Science and Technology Actions (COST actions): Short Term Scientific Mission Award dedicated to group leaders
The Dean's Research Initiatives Fund Award (PI), Faculty of Health Sciences, TCD (€20,000)
Innovation Bursary for post-doctoral researchers (€5000)
Memberships
International Society for Magnetic Resonance in Medicine
European Technology Platform Nanomedicine
Federation of European Neuroscience Societies