Biography
Having graduated from Trinity College Dublin (TCD) in 2012 with a first class honours degree in Biochemistry with Immunology, I was awarded an Irish Research Council-Enterprise Partnership Scheme Scholarship to undertake a PhD in the School of Biochemistry and Immunology at TCD. This work, which had a focus on mucosal vaccine adjuvant discovery, was performed in the Adjuvant Research Group under the supervision of Professor Ed Lavelle at the Trinity Biomedical Sciences Institute. I successfully defended my PhD thesis in September 2016 and continued my research as a Post-doc in the same group until December 2017. In January 2018 I accepted a position as a Research Associate at the University of Manchester, working under the supervision of Professor Mark Travis. Here I investigated novel roles for TGFß-activating integrins in the context of anti-viral memory T cell biology, work I presented at a number of national and international conferences. I also contributed to work published in the Journal of Experimental Medicine, Science and the Journal of Immunology. In February 2021 I was awarded a Marie Sk"odowska-Curie Individual Fellowship by the European Commission to investigate the role of PYHIN family proteins in dendritic cell-mediated regulation of anti-viral memory T cell responses. I undertook this project in the Immune Sensing and Signalling Research Group, led by Prof. Andrew Bowie in the School of Biochemistry and Immunology at TCD and in July 2023 was awarded an eight year University Research Fellowship from The Royal Society to establish my own group at TCD, building on my previous work to investigate how modulating early innate immune responses following viral infection can influence protective memory T cell differentiation and function.
Publications and Further Research Outputs
Peer-Reviewed Publications
Ed C. Lavelle, Craig P. McEntee, Vaccine adjuvants: Tailoring innate recognition to send the right message, Immunity, 57, (4), 2024, p772-789
Dow J, Cytlak UM, Casulli J, McEntee CP, Smedley C, Hodge SH, D'Elia RV, Hepworth MR, Travis MA., Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis., Journal of immunology (Baltimore, Md. : 1950), 210, (5), 2023, p618-627
Muñoz-Wolf, N. and Ward, R.W. and Hearnden, C.H. and Sharp, F.A. and Geoghegan, J. and O'Grady, K. and McEntee, C.P. and Shanahan, K.A. and Guy, C. and Bowie, A.G. and Campbell, M. and Roces, C.B. and Anderluzzi, G. and Webb, C. and Perrie, Y. and Creagh, E. and Lavelle, E.C., Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles, Cell Reports Medicine, 4, (1), 2023
Turley, J.L. and Moran, H.B.T. and McEntee, C.P. and O'Grady, K. and Muñoz-Wolf, N. and Jin, L. and Follmann, F. and Andersen, P. and Andersson, M. and Lavelle, E.C., Chitin-derived polymer deacetylation regulates mitochondrial reactive oxygen species dependent cGAS-STING and NLRP3 inflammasome activation, Biomaterials, 275, (120961), 2021
Albutti, A. and Longet, S. and McEntee, C.P. and Quinn, S. and Liddicoat, A. and Rîmniceanu, C. and Lycke, N. and Lynch, L. and Cardell, S. and Lavelle, E.C., Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines, Vaccines, 9, (6), 2021
Craig P. McEntee, Hannah B.T. Moran, Natalia Muñoz-Wolf, Alex M. Liddicoat, Elizabeth C. Carroll, Jeanette Erbo-Wern, Ivan S. Coulter, Peter Andersen, Frank Follmann, Ed C. Lavelle, Type I IFN signalling is required for cationic adjuvant formulation (CAF)01-induced cellular immunity and mucosal priming, Vaccine, 38, (3), 2020, p635--643
McEntee, Craig P., Gunaltay, Sezin, Travis, Mark A., Regulation of barrier immunity and homeostasis by integrin"mediated transforming growth factor ß activation, Immunology, 160, (2), 2020, p139-148
McEntee, C.P. and Finlay, C.M. and Lavelle, E.C., Divergent roles for the IL-1 family in gastrointestinal homeostasis and inflammation, Frontiers in Immunology, 10, (JUN), 2019
Longet, S. and Abautret-Daly, A. and Davitt, C.J.H. and McEntee, C.P. and Aversa, V. and Rosa, M. and Coulter, I.S. and Holmgren, J. and Raghavan, S. and Lavelle, E.C., An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses, npj Vaccines, 4, (1), 2019
Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR., Migratory DCs activate TGF-ß to precondition naïve CD8+ T cells for tissue-resident memory fate., Science (New York, N.Y.), 366, (6462), 2019, peaav5728
Davitt, C.J.H. and Longet, S. and Albutti, A. and Aversa, V. and Nordqvist, S. and Hackett, B. and McEntee, C.P. and Rosa, M. and Coulter, I.S. and Lebens, M. and Tobias, J. and Holmgren, J. and Lavelle, E.C., Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines, Mucosal Immunology, 12, (4), 2019, p1055-1064
Kelly A, Gunaltay S, McEntee CP, Shuttleworth EE, Smedley C, Houston SA, Fenton TM, Levison S, Mann ER, Travis MA., Human monocytes and macrophages regulate immune tolerance via integrin "vß8-mediated TGFß activation., The Journal of experimental medicine, 215, (11), 2018, p2725-2736
Carroll, E.C., Jin, L., Mori, A., Muñoz-Wolf, N., Oleszycka, E., Moran, H.B.T., Mansouri, S., McEntee, C.P., Lambe, E., Agger, E.M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K.A., Bowie, A.G., Lavelle, E.C., The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons, Immunity, 44, (3), 2016, p597 - 608
Davitt, C.J.H., McNeela, E.A., Longet, S., Tobias, J., Aversa, V., McEntee, C.P., Rosa, M., Coulter, I.S., Holmgren, J., Lavelle, E.C., A novel adjuvanted capsule based strategy for oral vaccination against infectious diarrhoeal pathogens, Journal of Controlled Release, 233, 2016, p162-173
Non-Peer-Reviewed Publications
CP McEntee, S Houston, CM Finlay, S Rossi, G Liu, TN Shaw, J Casulli, M Fife, C Smedley, View ORCID ProfileTS Griffith, View ORCID ProfileM Pepper, T Hussell, PM Hansbro, View ORCID ProfileJ-M Schwartz, H Paidassi, MA Travis, A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFß, BioRxiv, (2023.03.02.527395), 2023
Chapter 63 - Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune-Stimulating Complexes (ISCOMs) in, editor(s)Jiri Mestecky Michael W. Russell Hilde Cheroutre Warren Strober Brian L. Kelsall Bart N. Lambrecht , Mucosal Immunology (Fourth Edition), https://doi.org/10.1016/B978-0-12-415847-4.00063-X, 2015, pp1211 - 1231, [C. McEntee, E.C. Lavelle and D.T. O'Hagan]
Research Expertise
Recognition
Representations
Selected to represent the School of Biochemistry & Immunology as a postdoctoral representative in audit meetings with both independent external reviewers and stakeholders (Science Foundation Ireland).
Awards and Honours
7th European Congress of Immunology Bright Sparks Award
Royal Society University Research Fellowship
Marie Curie Individual Fellowship
Irish Research Council Enterprise Partnership Scheme Scholarship
Memberships
Irish Society for Immunology
British Society for Immunology