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Professor Matthew Campbell
Professor, Genetics
Professor, Trinity Inst. of Neurosciences (TCIN)

Publications and Further Research Outputs

Peer-Reviewed Publications

Ozaki, E. and Delaney, C. and Campbell, M. and Doyle, S.L., Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration, Experimental Eye Research, 217, (108953), 2022 Journal Article, 2022 DOI TARA - Full Text

Dion-Albert, L. and Cadoret, A. and Doney, E. and Kaufmann, F.N. and Dudek, K.A. and Daigle, B. and Parise, L.F. and Cathomas, F. and Samba, N. and Hudson, N. and Lebel, M. and Aardema, F. and Ait Bentaleb, L. and Beauchamp, J. and Bendahmane, H. and Benoit, E. and Bergeron, L. and Bertone, A. and Bertrand, N. and Berube, F.-A. and Blanchet, P. and Boissonneault, J. and Bolduc, C.J. and Bonin, J.-P. and Borgeat, F. and Boyer, R. and Breault, C. and Breton, J.-J. and Briand, C. and Brodeur, J. and Brule, K. and Brunet, L. and Carriere, S. and Chartrand, C. and Chenard-Soucy, R. and Chevrette, T. and Cloutier, E. and Cloutier, R. and Cormier, H. and Cote, G. and Cyr, J. and David, P. and De Benedictis, L. and Delisle, M.-C. and Deschenes, P. and Desjardins, C.D. and Desmarais, G. and Dubreucq, J.-L. and Dumont, M. and Dumais, A. and Ethier, G. and Feltrin, C. and Felx, A. and Findlay, H. and Fortier, L. and Fortin, D. and Fortin, L. and Francois, N. and Gagne, V. and Gagnon, M.-P. and Gignac-Hens, M.-C. and Giguere, C.-E. and Godbout, R. and Grou, C. and Guay, S. and Guillem, F. and Hachimi-Idrissi, N. and Herry, C. and Hodgins, S. and Homayoun, S. and Jemel, B. and Joyal, C. and Kouassi, E. and Labelle, R. and Lafortune, D. and Lahaie, M. and Lahlafi, S. and Lalonde, P. and Landry, P. and Lapaige, V. and Larocque, G. and Larue, C. and Lavoie, M. and Leclerc, J.-J. and Lecomte, T. and Lecours, C. and Leduc, L. and Lelan, M.-F. and Lemieux, A. and Lesage, A. and Letarte, A. and Lepage, J. and Levesque, A. and Lipp, O. and Luck, D. and Lupien, S. and Lusignan, F.-A. and Lusignan, R. and Luyet, A.J. and Lynhiavu, A. and Melun, J.-P. and Morin, C. and Nicole, L. and Noel, F. and Normandeau, L. and O†Connor, K. and Ouellette, C. and Parent, V. and Parizeau, M.-H. and Pelletier, J.-F. and Pelletier, J. and Pelletier, M. and Plusquellec, P. and Poirier, D. and Potvin, S. and Prevost, G. and Prevost, M.-J. and Racicot, P. and Racine-Gagne, M.-F. and Renaud, P. and Ricard, N. and Rivet, S. and Rolland, M. and Sasseville, M. and Safadi, G. and Smith, S. and Smolla, N. and Stip, E. and Teitelbaum, J. and Thibault, A. and Thibault, L. and Thibault, S. and Thomas, F. and Todorov, C. and Tourjman, V. and Tranulis, C. and Trudeau, S. and Trudel, G. and Vacri, N. and Valiquette, L. and Vanier, C. and Villeneuve, K. and Villeneuve, M. and Vincent, P. and Wolfe, M. and Xiong, L. and Zizzi, A. and Campbell, M. and Turecki, G. and Mechawar, N. and Menard, C., Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue, Nature Communications, 13, (1), 2022 Journal Article, 2022 DOI

Greene, C. and Campbell, M., Immunohistochemical Analysis of Tight Junction Proteins, Methods in Molecular Biology, 2492, 2022, p307-314 Journal Article, 2022 DOI

Boyce, M. and Xin, Y. and Chowdhury, O. and Shang, P. and Liu, H. and Koontz, V. and Strizhakova, A. and Nemani, M. and Hose, S. and Zigler, J.S. and Campbell, M. and Sinha, D. and Handa, J.T. and Kaarniranta, K. and Qian, J. and Ghosh, S., Microgliaâ€"Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model, Cells, 11, (22), 2022 Journal Article, 2022 DOI

Greene, C. and Hanley, N. and Reschke, C.R. and Reddy, A. and MÀe, M.A. and Connolly, R. and Behan, C. and O†Keeffe, E. and Bolger, I. and Hudson, N. and Delaney, C. and Farrell, M.A. and O†Brien, D.F. and Cryan, J. and Brett, F.M. and Beausang, A. and Betsholtz, C. and Henshall, D.C. and Doherty, C.P. and Campbell, M., Microvascular stabilization via blood-brain barrier regulation prevents seizure activity, Nature Communications, 13, (1), 2022 Journal Article, 2022 DOI

Chang, J.-H. and Greene, C. and Frudd, K. and Araujo dos Santos, L. and Futter, C. and Nichols, B.J. and Campbell, M. and Turowski, P., Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier, Cell Reports Medicine, 3, (1), 2022 Journal Article, 2022 DOI

Amoo, M. and O'Halloran, P.J. and Henry, J. and Ben Husien, M. and Brennan, P. and Campbell, M. and Caird, J. and Curley, G.F., Permeability of the Blood-Brain Barrier after Traumatic Brain Injury: Radiological Considerations, Journal of Neurotrauma, 39, (1-2), 2022, p20-34 Journal Article, 2022 DOI

Hashimoto, Y. and Poirier, K. and Boddaert, N. and Hubert, L. and Aubart, M. and Kaminska, A. and Alison, M. and Desguerre, I. and Munnich, A. and Campbell, M., Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia, Brain : a journal of neurology, 145, (10), 2022, p3374-3382 Journal Article, 2022 DOI

Gibbons, L. and Ozaki, E. and Greene, C. and Trappe, A. and Carty, M. and Coppinger, J.A. and Bowie, A.G. and Campbell, M. and Doyle, S.L., SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration, Frontiers in Neuroscience, 16, (852114), 2022 Journal Article, 2022 DOI TARA - Full Text

Cassidy, P.S. and Kelly, R.A. and Reina-Torres, E. and Sherwood, J.M. and Humphries, M.M. and Kiang, A.-S. and Farrar, G.J. and O'Brien, C. and Campbell, M. and Stamer, W.D. and Overby, D.R. and Humphries, P. and O'Callaghan, J., siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model, Molecular Therapy - Methods and Clinical Development, 20, 2021, p86-94 Journal Article, 2021 DOI TARA - Full Text

Amoo, Michael and Henry, Jack and O'Halloran, Philip J and Brennan, Paul and Husien, Mohammed Ben and Campbell, Matthew and Caird, John and Javadpour, Mohsen and Curley, Gerard F, S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy, Neurosurgical review, 2021 Journal Article, 2021 DOI

O'Leary, Fionn and Campbell, Matthew, The blood-retina barrier in health and disease, The FEBS journal, 2021 Journal Article, 2021 DOI TARA - Full Text

Harford, D.A. and Delaney, C. and O'Callaghan, J. and Hudson, N. and Connolly, R. and Doyle, S. and Farrell, M. and Doherty, C.P. and Cahill, M. and Campbell, M., Decreased CSF1R Signaling and the Accumulation of Reticular Pseudo- Drusen?, Ophthalmic Surgery Lasers and Imaging Retina, 52, (12), 2021, p666-671 Journal Article, 2021 DOI

Hashimoto, Yosuke and Campbell, Matthew and Tachibana, Keisuke and Okada, Yoshiaki and Kondoh, Masuo, Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier, Biological & pharmaceutical bulletin, 44, (10), 2021, p1380â€"1390 Journal Article, 2021 DOI TARA - Full Text

Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A., Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction, Brain, 2021 Journal Article, 2021

Li, Xiaoqing and Vemireddy, Vamsidhara and Cai, Qi and Xiong, Hejian and Kang, Peiyuan and Li, Xiuying and Giannotta, Monica and Hayenga, Heather N and Pan, Edward and Sirsi, Shashank R and Mateo, Celine and Kleinfeld, David and Greene, Chris and Campbell, Matthew and Dejana, Elisabetta and Bachoo, Robert and Qin, Zhenpeng, Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles, Nano letters, 21, (22), 2021, p9805â€"9815 Journal Article, 2021 DOI

Amoo, M. and Henry, J. and Pender, N. and Brennan, P. and Campbell, M. and Javadpour, M., Blood-brain barrier permeability imaging as a predictor for delayed cerebral ischaemia following subarachnoid haemorrhage. A narrative review, Acta Neurochirurgica, 163, (5), 2021, p1457-1467 Journal Article, 2021 DOI

Reschke, C.R. and Silva, L.F.A. and Vangoor, V.R. and Rosso, M. and David, B. and Cavanagh, B.L. and Connolly, N.M.C. and Brennan, G.P. and Sanz-Rodriguez, A. and Mooney, C. and Batool, A. and Greene, C. and Brennan, M. and Conroy, R.M. and RÃŒber, T. and Prehn, J.H.M. and Campbell, M. and Pasterkamp, R.J. and Henshall, D.C., Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy, Molecular Therapy, 29, (6), 2021, p2041-2052 Journal Article, 2021 TARA - Full Text DOI

Delaney, C. and Farrell, M. and Doherty, C.P. and Brennan, K. and O†Keeffe, E. and Greene, C. and Byrne, K. and Kelly, E. and Birmingham, N. and Hickey, P. and Cronin, S. and Savvides, S.N. and Doyle, S.L. and Campbell, M., Attenuated CSF-1R signalling drives cerebrovascular pathology, EMBO Molecular Medicine, 13, (2), 2021 Journal Article, 2021 TARA - Full Text DOI

Scott, L.M. and Vincent, E.E. and Hudson, N. and Neal, C. and Jones, N. and Lavelle, E.C. and Campbell, M. and Halestrap, A.P. and Dick, A.D. and Theodoropoulou, S., Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors, JCI Insight, 6, (8), 2021 Journal Article, 2021 DOI TARA - Full Text

Kelly, Ruth A and Perkumas, Kristin M and Campbell, Matthew and Farrar, G Jane and Stamer, W Daniel and Humphries, Pete and O'Callaghan, Jeffrey and O'Brien, Colm J, Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma, International journal of molecular sciences, 22, (17), 2021 Journal Article, 2021 DOI TARA - Full Text

Hudson, Natalie and Campbell, Matthew, Tight Junctions of the Neurovascular Unit, Frontiers in molecular neuroscience, 14, 2021, p752781 Journal Article, 2021 TARA - Full Text DOI

Goncalves, Andreia and Dreffs, Alyssa and Lin, Cheng-Mao and Sheskey, Sarah and Hudson, Natalie and Keil, Jason and Campbell, Matthew and Antonetti, David A, Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes, Diabetes, 70, (7), 2021, p1549â€"1560 Journal Article, 2021 DOI

Laksari K, Fanton M, Wu LC, Nguyen TH, Kurt M, Giordano C, Kelly E, O'Keeffe E, Wallace E, Doherty C, Campbell M, Tiernan S, Grant G, Ruan J, dummy-AUTHOR_name, Camarillo DB, Multi-Directional Dynamic Model for Traumatic Brain Injury Detection., Journal of neurotrauma, 2020 Journal Article, 2020

Hudson, N. and Cahill, M. and Campbell, M., Inner blood-retina barrier involvement in dry age-related macular degeneration (AMD) pathology, Neural Regeneration Research, 15, (9), 2020, p1656-1657 Journal Article, 2020 DOI

Hashimoto, Y. and Campbell, M., Tight junction modulation at the blood-brain barrier: Current and future perspectives, Biochimica et Biophysica Acta - Biomembranes, 1862, (9), 2020 Journal Article, 2020 DOI

Kenna, P.F. and Humphries, M.M. and Kiang, A.-S. and Brabet, P. and Guillou, L. and Ozaki, E. and Campbell, M. and Jane Farrar, G. and Koenekoop, R. and Humphries, P., Advanced late-onset retinitis pigmentosa with dominant-acting D477G RPE65 mutation is responsive to oral synthetic retinoid therapy, BMJ Open Ophthalmology, 5, (1), 2020 Journal Article, 2020 DOI TARA - Full Text

Veksler, R. and Vazana, U. and Serlin, Y. and Prager, O. and Ofer, J. and Shemen, N. and Fisher, A.M. and Minaeva, O. and Hua, N. and Saar-Ashkenazy, R. and Benou, I. and Riklin-Raviv, T. and Parker, E. and Mumby, G. and Kamintsky, L. and Beyea, S. and Bowen, C.V. and Shelef, I. and O'Keeffe, E. and Campbell, M. and Kaufer, D. and Goldstein, L.E. and Friedman, A., Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players, Brain, 143, (6), 2020, p1826-1842 Journal Article, 2020 DOI

Greene, C. and Hanley, N. and Campbell, M., Blood-brain barrier associated tight junction disruption is a hallmark feature of major psychiatric disorders, Translational Psychiatry, 10, (1), 2020 Journal Article, 2020 DOI TARA - Full Text

Tiernan S, Meagher A, O'Sullivan D, O'Keeffe E, Kelly E, Wallace E, Doherty CP, Campbell M, Liu Y, Domel AG, Concussion and the severity of head impacts in mixed martial arts., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 234, 2020, 1472 - 1483 Journal Article, 2020 TARA - Full Text

Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL., Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration., Cell reports, 30, (7), 2020, p2209-2224.e5 Journal Article, 2020 DOI TARA - Full Text

Ozaki, Ema, Gibbons, Luke, Neto, Nuno GB, Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew and Doyle, Sarah L, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020 Journal Article, 2020 TARA - Full Text DOI

Naylor, A. and Hopkins, A. and Hudson, N. and Campbell, M., Tight junctions of the outer blood retina barrier, International Journal of Molecular Sciences, 21, (1), 2020 Journal Article, 2020 TARA - Full Text DOI

O'Keeffe, E. and Kelly, E. and Liu, Y. and Giordano, C. and Wallace, E. and Hynes, M. and Tiernan, S. and Meagher, A. and Greene, C. and Hughes, S. and Burke, T. and Kealy, J. and Doyle, N. and Hay, A. and Farrell, M. and Grant, G.A. and Friedman, A. and Veksler, R. and Molloy, M.G. and Meaney, J.F. and Pender, N. and Camarillo, D. and Doherty, C.P. and Campbell, M., Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury, Journal of neurotrauma, 37, (2), 2020, p347-356 Journal Article, 2020 DOI

Kiang, A.-S. and Kenna, P.F. and Humphries, M.M. and Ozaki, E. and Koenekoop, R.K. and Campbell, M. and Jane Farrar, G. and Humphries, P., Properties and therapeutic implications of an enigmatic d477g rpe65 variant associated with autosomal dominant retinitis pigmentosa, Genes, 11, (12), 2020, p1-21 Journal Article, 2020 TARA - Full Text DOI

O†Callaghan, J. and Campbell, M. and Humphries, P., Intracameral delivery of AAV to corneal endothelium for expression of secretory proteins, Methods in Molecular Biology, 1950, 2019, p263-270 Journal Article, 2019 DOI

Farrell, M. and Aherne, S. and O'Riordan, S. and O'Keeffe, E. and Greene, C. and Campbell, M., Blood-brain barrier dysfunction in a boxer with chronic traumatic encephalopathy and schizophrenia, Clinical Neuropathology, 38, (2), 2019, p51-58 Journal Article, 2019 DOI

O'Connor, C. and Ramanath, N. and Campbell, M., Pharmacokinetics of Systemic Drug Delivery, 2019, 39-56pp Book, 2019 DOI

Greene, C. and Campbell, M. and Janigro, D., Fundamentals of Brain-Barrier Anatomy and Global Functions, 2019, 3-20pp Book, 2019 DOI

Augustine, J. and Pavlou, S. and Ali, I. and Harkin, K. and Ozaki, E. and Campbell, M. and Stitt, A.W. and Xu, H. and Chen, M., IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment, Journal of Neuroinflammation, 16, (1), 2019 Journal Article, 2019 TARA - Full Text DOI

Greene, C. and Hanley, N. and Campbell, M., Claudin-5: Gatekeeper of neurological function, Fluids and Barriers of the CNS, 16, (1), 2019 Journal Article, 2019 DOI TARA - Full Text

Hudson, N. and Celkova, L. and Hopkins, A. and Greene, C. and Storti, F. and Ozaki, E. and Fahey, E. and Theodoropoulou, S. and Kenna, P.F. and Humphries, M.M. and Curtis, A.M. and Demmons, E. and Browne, A. and Liddie, S. and Lawrence, M.S. and Grimm, C. and Cahill, M.T. and Humphries, P. and Doyle, S.L. and Campbell, M., Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy, JCI Insight, 4, (15), 2019, p130273- Journal Article, 2019 TARA - Full Text DOI

Hudson, N. and Campbell, M., Inner Blood-Retinal Barrier Regulation in Retinopathies, Advances in Experimental Medicine and Biology, 1185, 2019, p329-333 Journal Article, 2019 DOI

Campbell, M. and Doyle, S.L., Current perspectives on established and novel therapies for pathological neovascularization in retinal disease, Biochemical Pharmacology, 164, 2019, p321-325 Journal Article, 2019 DOI

Crosbie, D.E. and Keaney, J. and Tam, L.C.S. and Daniel Stamer, W. and Campbell, M. and Humphries, P., Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI, Magnetic Resonance Imaging, 59, 2019, p10-16 Journal Article, 2019 DOI

Doherty, C.P., O'Keeffe. E., Keaney, J., Lawlor, B.A., Coen, R.F., Farrell, M., Campbell, M., Neuropolypathology as a result of severe traumatic brain injury? , Clinical Neuropathology, 38, (1), 2019, p14 - 22 Journal Article, 2019 DOI

Kealy, J. and Greene, C. and Campbell, M., Blood-brain barrier regulation in psychiatric disorders, Neuroscience Letters, 2018 Journal Article, 2018 TARA - Full Text DOI

Campbell, M. and Cassidy, P.S. and O'Callaghan, J. and Crosbie, D.E. and Humphries, P., Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension, Progress in Retinal and Eye Research, 62, 2018, p120-133 Journal Article, 2018 TARA - Full Text DOI

Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbroucke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Correction: Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017 [Fluids Barriers CNS 14, (2017) (31)] DOI: 10.1186/s12987-017-0079-9, Fluids and Barriers of the CNS, 15, (1), 2018, p3- Journal Article, 2018 DOI TARA - Full Text

Alamillo-Ferrer, C. and Curle, J.M. and Davidson, S.C. and Lucas, S.C.C. and Atkinson, S.J. and Campbell, M. and Kennedy, A.R. and Tomkinson, N.C.O., Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines, Journal of Organic Chemistry, 83, (12), 2018, p6728-6740 Journal Article, 2018 DOI

Theodoropoulou S, Copland D.A, Liu J, Wu J, Gardner P.J, Ozaki E, Doyle S.L, Campbell M, Dick A.D, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye, Journal of Pathology, 241, (1), 2017, p45 - 56 Journal Article, 2017 URL DOI

C Greene, J Kealy, M M Humphries, Y Gong, J Hou, N Hudson, L M Cassidy, R Martiniano, V Shashi, S R Hooper, G A Grant, P F Kenna, K Norris, C K Callaghan, M dN Islam, S M O'Mara, Z Najda, S G Campbell, J S Pachter, J Thomas, N M Williams, P Humphries, K C Murphy, M Campbell, Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia, Molecular Psychiatry, 2017 Journal Article, 2017 DOI

O'Callaghan, J. and Crosbie, D.E. and Cassidy, P.S. and Sherwood, J.M. and FlÃŒgel-Koch, C. and LÃŒtjen-Drecoll, E. and Humphries, M.M. and Reina-Torres, E. and Wallace, D. and Kiang, A.-S. and Campbell, M. and Stamer, W.D. and Overby, D.R. and O'Brien, C. and Tam, L.C.S. and Humphries, P., Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma, Human Molecular Genetics, 26, (7), 2017, p1230-1246 Journal Article, 2017 DOI

Shah T.M, Gupta S.M, Chatterjee P, Campbell M, Martins R.N, Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer†s disease, Molecular Psychiatry, 22, 2017, p353-363- Journal Article, 2017 DOI URL

Menard, C. and Pfau, M.L. and Hodes, G.E. and Kana, V. and Wang, V.X. and Bouchard, S. and Takahashi, A. and Flanigan, M.E. and Aleyasin, H. and Leclair, K.B. and Janssen, W.G. and Labonté, B. and Parise, E.M. and Lorsch, Z.S. and Golden, S.A. and Heshmati, M. and Tamminga, C. and Turecki, G. and Campbell, M. and Fayad, Z.A. and Tang, C.Y. and Merad, M. and Russo, S.J., Social stress induces neurovascular pathology promoting depression, Nature Neuroscience, 20, (12), 2017, p1752-1760 Journal Article, 2017 DOI

Tam L.C.S, Reina-Torres E, Sherwood J.M, Cassidy P.S, Crosbie D.E, LÃ"tjen-Drecoll E, FlÃ"gel-Koch C, Perkumas K, Humphries M.M, Kiang A.-S, O'Callaghan J, Callanan J.J, Read A.T, Ethier C.R, O'Brien C, Lawrence M, Campbell M, Stamer W.D, Overby D.R, Humphries P, Enhancement of outflow facility in the murine eye by targeting selected tight-junctions of Schlemm's canal endothelia, Scientific Reports, 7, 2017, p40717- Journal Article, 2017 URL TARA - Full Text DOI

Greenwood, J. and Hammarlund-Udenaes, M. and Jones, H.C. and Stitt, A.W. and Vandenbrouke, R.E. and Romero, I.A. and Campbell, M. and Fricker, G. and Brodin, B. and Manninga, H. and Gaillard, P.J. and Schwaninger, M. and Webster, C. and Wicher, K.B. and Khrestchatisky, M., Current research into brain barriers and the delivery of therapeutics for neurological diseases: A report on CNS barrier congress London, UK, 2017, Fluids and Barriers of the CNS, 14, (1), 2017, p31- Journal Article, 2017 DOI TARA - Full Text

Delaney, C. and Campbell, M., The blood brain barrier: Insights from development and ageing, Tissue Barriers, 5, (4), 2017, pe1373897 - Journal Article, 2017 DOI

O'Keeffe E, Campbell M, Modulating the paracellular pathway at the bloodâ€"brain barrier: current and future approaches for drug delivery to the CNS, Drug Discovery Today: Technologies, 20, 2016, p35 - 39 Journal Article, 2016 URL DOI

5. S Theodoropoulou, S Doyle, D Copland, J Liu, J Wu, M Campbell, A Dick, Interleukin 33/ST2 signaling regulates inflammatory response in choroidal stroma and ocular angiogenesis: implications for age‐related macular degeneration., Acta Ophthalmologica, 93, (S255), 2016 Conference Paper, 2016

Doherty C.P, O'Keefe E, Wallace E, Loftus T, Keaney J, Kealy J, Humphries M.M, Molloy M.G, Meaney J.F, Farrell M, Campbell M, Blood-Brain Barrier Dysfunction as a Hallmark Pathology in Chronic Traumatic Encephalopathy, Journal of Neuropathology and Experimental Neurology, 75, (7), 2016, p656 - 662 Journal Article, 2016 URL DOI

Oleszycka, E., Moran, H.B.T., Tynan, G.A., Hearnden, C.H., Coutts, G., Campbell, M., Allan, S.M., Scott, C.J. and Lavelle, E.C. , IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination. , FEBS Journal, 283, (1), 2016, p9 - 24 Journal Article, 2016 DOI

Greene C, Campbell M, Tight junction modulation of the blood brain barrier: CNS delivery of small molecules, Tissue Barriers, 4, (1), 2016, pe1138017- Journal Article, 2016 DOI URL

Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203 Journal Article, 2015 DOI TARA - Full Text

Ranzinger R, Aoki-Kinoshita K.F, Campbell M.P, Kawano S, Lütteke T, Okuda S, Shinmachi D, Shikanai T, Sawaki H, Toukach P, Matsubara M, Yamada I, Narimatsu H, GlycoRDF: An ontology to standardize glycomics data in RDF, Bioinformatics, 31, (6), 2015, p919 - 925 Journal Article, 2015 URL DOI TARA - Full Text

Campbell M.P, Royle L, Rudd P.M, Glycobase and autoGU: Resources for interpreting HPLC-glycan data, Glycoinformatics: Methods in Molecular Biology, 1273, 2015, 17-28 Journal Article, 2015 DOI URL

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M., Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier., Science Advances, 1, (8), 2015, p10.1126/sci adv.1500472 Journal Article, 2015

Doyle SL, López FJ, Humphries P, Adamson P, Campbell M, Author Response: The Role of IL-18 in the Treatment of AMD., Invest Ophthalmol Vis Sci, 56, (3), 2015, p8237-8 Journal Article, 2015 DOI

Keaney J, Campbell M, The dynamic blood-brain barrier, FEBS Journal, 282, (21), 2015, p4067 - 4079 Journal Article, 2015 URL DOI

Abrahams J.L, Packer N.H, Campbell M.P, Relative quantitation of multi-antennary N-glycan classes: Combining PGC-LC-ESI-MS with exoglycosidase digestion, Analyst, 140, (16), 2015, p5444 - 5449 Journal Article, 2015 URL DOI

Ozaki E, Campbell M, Doyle S.L, Targeting the NLRP3 inflammasome in chronic inflammatory diseases: Current perspectives, Journal of Inflammation Research, 8, 2015, p15 - 27 Journal Article, 2015 TARA - Full Text URL DOI

Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M, IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates., Invest Ophthalmol Vis Sci, 56, (9), 2015, p5424-30 Journal Article, 2015 DOI

Ozaki, E., Campbell, M., Kiang, A.S., (...), Doyle, S.L., Humphries, P. , Inflammation in age-related macular degeneration., Advances in experimental medicine and biology, 801, 2014, p229-235 Journal Article, 2014 DOI

Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC, Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1 alpha-dependent inflammation., Diabetes, 63, (3), 2014, p2037-2050 Journal Article, 2014 TARA - Full Text DOI

York W.S, Agravat S, Aoki-Kinoshita K.F, Mcbride R, Campbell M.P, Costello C.E, Dell A, Feizi T, Haslam S.M, Karlsson N, Khoo K.-H, Kolarich D, Liu Y, Novotny M, Packer N.H, Paulson J.C, Rapp E, Ranzinger R, Rudd P.M, Smith D.F, Struwe W.B, Tiemeyer M, Wells L, Zaia J, Kettner C, MIRAGE: The minimum information required for a glycomics experiment, Glycobiology, 24, (5), 2014, p402 - 406 Journal Article, 2014 URL DOI

Doyle S.L, Adamson P, López F.J, Humphries P, Campbell M, Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration, Nature Medicine, 20, (12), 2014, p1376 - 1377 Journal Article, 2014 DOI URL

Doyle, S.L., Adamson, P., López, F.J., Humphries, P., Campbell, M. , Interleukin-18 bioactivity and dose: Data interpretation at a crossroads, Investigative Ophthalmology and Visual Science, 55, (12), 2014, p8349 Journal Article, 2014 DOI

Nguyen, A.T., Campbell, M., Kiang, A.S., Humphries, M.M., Humphries, P. , Current therapeutic strategies for P23H RHO-linked RP., Advances in experimental medicine and biology, 801, 2014, p471-476 Journal Article, 2014 DOI

Kiang, A.S., Humphries, M.M., Campbell, M., Humphries, P. , Antioxidant therapy for retinal disease., Advances in experimental medicine and biology, 801, 2014, p783-789 Journal Article, 2014 DOI

Hudson N, Powner M.B, Sarker M.H, Burgoyne T, Campbell M, Ockrim Z.K, Martinelli R, Futter C.E, Grant M.A, Fraser P.A, Shima D.T, Greenwood J, Turowski P, Differential apicobasal VEGF signaling at vascular blood-neural barriers, Developmental Cell, 30, (5), 2014, p541 - 552 Journal Article, 2014 TARA - Full Text DOI URL

Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230- Journal Article, 2014 TARA - Full Text DOI

7. S Doyle, PS Adamson, FJ Lopez, P Humphries, M Campbell , IL-18 promotes wound healing and has anti-angiogenic properties in the eye., Investigative Ophthalmology & Visual Science, ARVO, Orlando, 56 (7), , 2014, pp2462-2462 Conference Paper, 2014

Campbell, M., Doyle, S.L., Ozaki, E., (...), Humphries, M.M., Humphries, P. , An overview of the involvement of interleukin-18 in degenerative retinopathies., Advances in experimental medicine and biology, 801, 2014, p409-415 Journal Article, 2014 DOI

Campbell, M., Doyle, S., Humphries, P. , IL-18: A new player in immunotherapy for age-related macular degeneration?, Expert Review of Clinical Immunology, 10, (10), 2014, p1273-1275 Journal Article, 2014 DOI

Rouine, J, Gobbo, OL, Campbell, M, Gigliucci, V, Ogden, I, Smith, KM, Duffy, P, Behan, B, Byrne, D, Kelly, ME, Blau, CW, Kerskens, CM, Harkin, A, MDMA "ecstasy' increases cerebral cortical perfusion determined by bolus-tracking arterial spin labelling (btASL) MRI, BRITISH JOURNAL OF PHARMACOLOGY, 169, (5), 2013, p974-987 Journal Article, 2013 DOI TARA - Full Text

Barrier modulation in drug delivery to the retina. in, Retinal Degeneration, 2013, pp371-80 , [Campbell M, Humphries MM, Humphries P] Book Chapter, 2013 DOI

Humphries P, Humphries MM, Tam LC, Farrar GJ, Kenna PF, Campbell M, Kiang A-S. , Hereditary retinopathies: progress in development of genetic and molecular therapies., SpringerBriefs in Genetics, Springer NY. , 2013 Book, 2013

9. M Campbell, E Ozaki, MM Humphries, PS Adamson, P Humphries, NLRP3 independent mechanisms of RPE cell death, Investigative Ophthalmology & Visual Science, ARVO, Seattle, 55 (13), 2013, pp1318-1318 Conference Paper, 2013

Campbell M, Doyle SL, An eye on the future of inflammasomes and drug development in AMD., Journal of molecular medicine (Berlin, Germany), 91, (9), 2013, p1059-70 Journal Article, 2013 DOI

Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Jane Farrar G, Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy., European journal of human genetics : EJHG, 21, (1), 2013, p62-8 Journal Article, 2013 TARA - Full Text DOI

Campbell M, Humphries P, The blood-retina barrier: tight junctions and barrier modulation., Advances in experimental medicine and biology, 763, 2012, p70-84 Journal Article, 2012 DOI

Tam LC, Kiang AS, Campbell M, Keaney J, Farrar GJ, Humphries MM, Kenna PF, Humphries P, Protein misfolding and potential therapeutic treatments in inherited retinopathies., Advances in experimental medicine and biology, 723, 2012, p567-72 Journal Article, 2012 DOI

Nguyen AT, Campbell M, Kenna PF, Kiang AS, Tam L, Humphries MM, Humphries P, Calpain and photoreceptor apoptosis., Advances in experimental medicine and biology, 723, 2012, p547-52 Journal Article, 2012 DOI

Campbell*, M, Doyle*, SL, Ozaki, E, Salomon, RG, Mori, A, Kenna, PF, Kiang, AS, Humphries, MM, Lavelle, EC, O'Neill, LAJ, Hollyfield, JG, and Humphries, P, NLRP3 plays a protective role during the development of age related macular degeneration through the induction of IL-18 by drusen components., Nature Medicine, 18, (5), 2012, p791 - 798 Journal Article, 2012 DOI

Hanrahan, F, Campbell, M, Nguyen, AT, Suzuki, M, Kiang, AS, Tam, LC, Gobbo, OL, Dhubhghaill, SN, Humphries, MM, Kenna, PF, Humphries, P, LaVail, MM, Ash, JD, Anderson, RE, Hollyfield, JG, Grimm, C, On Further Development of Barrier Modulation as a Technique for Systemic Ocular Drug Delivery, RETINAL DEGENERATIVE DISEASES, 723, 2012, p155-159 Journal Article, 2012 DOI

Campbell M, Hanrahan F, Gobbo OL, Kelly ME, Kiang AS, Humphries MM, Nguyen AT, Ozaki E, Keaney J, Blau CW, Kerskens CM, Cahalan SD, Callanan JJ, Wallace E, Grant GA, Doherty CP, Humphries P, Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury., Nature communications, 3, 2012, p849 Journal Article, 2012 DOI

Humphries MM, Kenna PF, Campbell M, Tam LC, Nguyen AT, Farrar GJ, Botto M, Kiang AS, Humphries P, C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa., European journal of human genetics : EJHG, 20, (1), 2012, p64-8 Journal Article, 2012 DOI

Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., Agholme, L., (...), Zuckerbraun, B., Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 8, (4), 2012, p445-544 Review Article, 2012 DOI

Bowne, SJ, Humphries, MM, Sullivan, LS, Kenna, PF, Tam, LCS, Kiang, AS, Campbell, M, Weinstock, GM, Koboldt, DC, Ding, L, Fulton, RS, Sodergren, EJ, Allman, D, Millington-Ward, S, Palfi, A, McKee, A, Blanton, SH, Slifer, S, Konidari, I, Farrar, GJ, Daiger, SP, Humphries, P, A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement, EUROPEAN JOURNAL OF HUMAN GENETICS, 19, (10), 2011, p1074-1081 Journal Article, 2011 DOI

Campbell M, Humphries MM, Nguyen ATH, Gobbo OL, Tam LCS, Suzuki M, Hanrahan F, Ozaki E, Farrar G-J, Kiang A-S, Kenna PF, Humphries P. , Systemic low-molecular weight drug delivery to pre-selected neuronal regions, EMBO Molecular Medicine, 3, (4), 2011, p235-245 Journal Article, 2011 TARA - Full Text

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE, Wnt signaling mediates pathological vascular growth in proliferative retinopathy., Circulation, 124, (17), 2011, p1871-81 Journal Article, 2011 DOI

Dagdan E, Morris D, Campbell M, Hill M, Rothermundt M, Kastner F, Hofoff C, Von Eiff, Krakowitzky P, Gill M, McKeon P, Roche S, Functional Assessment of a Promoter Polymorphism in S100B, a putative Risk Variant for Bipolar Disorder, Neuropsychiatric Genetics, 156, (6), 2011, p691 - 699 Journal Article, 2011 DOI

Keaney J, Campbell M, Humphries P, From RNA interference technology to effective therapy: how far have we come and how far to go?, Therapeutic delivery, 2, (11), 2011, p1395-406 Journal Article, 2011 DOI

Campbell M, Humphries P, Size-selective and in vitro assessment of inner blood retina barrier permeability., Methods in molecular biology (Clifton, N.J.), 763, 2011, p355-67 Journal Article, 2011 DOI

Bowne, S.J., Humphries, M.M., Sullivan, L.S., Kenna, P.F., Tam, L.C.S., Kiang, A.S., Campbell, M., (...), Humphries, P. , Erratum: A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (European Journal of Human Genetics (2011) 19 (1074-1081) DOI: 10.1038/ejhg.2011.86), 2011, - 1109 Miscellaneous, 2011 DOI

Ni Dhubhghaill SS, Cahill MT, Campbell M, Cassidy L, Humphries MM, Humphries P, The pathophysiology of cigarette smoking and age-related macular degeneration., Advances in Experimental Medicine and Biology, 664, (Part 4), 2010, p437-46 Journal Article, 2010 DOI

Hanrahan, F., Humphries, P., Campbell, M., RNAi-mediated barrier modulation: Synergies of the brain and eye, Therapeutic Delivery , 1, (4), 2010, p587-594 Journal Article, 2010 DOI

Campbell M, Nguyen AT, Kiang AS, Tam L, Kenna PF, Dhubhghaill SN, Humphries M, Farrar GJ, Humphries P, Reversible and size-selective opening of the inner Blood-Retina barrier: a novel therapeutic strategy., Advances in Experimental Medicine and Biology, 664, (Part 3), 2010, p301-8 Journal Article, 2010 DOI

Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P, Protection of photoreceptors in a mouse model of RP10., Advances in Experimental Medicine and Biology, 664, (Part 5), 2010, p559-65 Journal Article, 2010 DOI

Lawrence C. S. Tam, Anna-Sophia Kiang, Matthew Campbell, James Keaney, G. Jane Farrar, Marian M. Humphries, Paul F. Kenna and Pete Humphries, Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Human Molecular Genetics, 19, (22), 2010, p4421-4436 Journal Article, 2010 TARA - Full Text

Campbell M, Ozaki E, Humphries P, Systemic delivery of therapeutics to neuronal tissues: a barrier modulation approach., Expert Opinion on Drug Delivery, 7, (7), 2010, p859-69 Journal Article, 2010 DOI

O. Gobbo, M. Campbell, A.Kiang, P. Kenna, C. Kerskens, G. J. Farrar, P. Humphries, RNAi-MEDIATED REVERSIBLE OPENING OF THE BLOOD-BRAIN AND BLOODRETINA BARRIER, MRI Satellite Symposium, 2009 Meeting Abstract, 2009

Matthew Campbell, Anh T. H. Nguyen, Anna-Sophia Kiang, Lawrence C. S. Tam, Oliviero L. Gobbo, Christian Kerskens, Sorcha Ni Dhubhghaill, Marian M. Humphries, G.-Jane Farrar, Paul F. Kenna and Peter Humphries, An experimental platform for systemic drug delivery to the retina, Proceedings of the National Academy of Sciences of the United States, 106, (42), 2009, p17817 - 17822 Journal Article, 2009 DOI TARA - Full Text

Tam, LC, Kiang, AS, Kennan, A, Kenna, PF, Chadderton, N, Ader, M, Palfi, A, Aherne, A, Ayuso, C, Campbell, M, Reynolds, A, McKee, A, Humphries, MM, Farrar, GJ, Humphries, P, Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)., Human Molecular Genetics, 17, (14), 2008, p2084-2100 Journal Article, 2008 TARA - Full Text DOI

Campbell, M, Kiang, AS, Kenna, PF, Kerskens, C, Blau, C, O'Dwyer, L, Tivnan, A, Kelly, JA, Brankin, B, Farrar, GJ, Humphries, P, RNAi-mediated reversible opening of the blood-brain barrier., The Journal of Gene Medicine, 10, (8), 2008, p930 - 947 Journal Article, 2008 DOI

Campbell, M, Humphries, M, Kenna, P, Humphries, P, Brankin, B, Altered expression and interaction of adherens junction proteins in the developing OLM of the Rho(-/-) mouse., Experimental Eye Research, 85, (5), 2007, p714-720 Journal Article, 2007 DOI

Campbell M, Humphries MM, Kennan A, Kenna PF, Humphries P and Brankin B., Aberrant Retinal Tight Junction and Adherens junction protein expression in an animal model of autosomal recessive retinitis pigmentosa: The Rho (-/-) mouse, Exp. Eye Res, 83, (3), 2006, p484 - 492 Journal Article, 2006

Non-Peer-Reviewed Publications

1. K Mulfaul, E Ozaki, K Brennan, M Campbell, S Doyle, Investigating a role for Toll like receptor signaling in the pathogenesis of Age Related Macular Degeneration (AMD). , Investigative Ophthalmology & Visual Science, , ARVO, Seattle, 57 (12), (5010-5010), 2016 Conference Paper, 2016

12. GA Grant, C Wilson, M Campbell, S Li, P Humphries, A Johnson, Reversible Opening of the Blood-brain Barrier by Targeted Suppression of Claudin 5 To Enhance Drug Delivery into Brain Tumors. , Annals of Neurology , 2012 Conference Paper, 2012

10. C Doherty, E Wallace, M Campbell, P Humphries, Evaluation of an Acute RNAi-Mediated Therapeutic for Visual Dysfunction Associated with Traumatic Brain Injury., Neurology 2012, SAINT JAMES HOSPITAL DUBLIN (IRELAND), 2012 Conference Paper, 2012

Brankin B, Campbell M, Humphries M, Kennan A, Kenna P, Humphries P, Zonulas occluden 1 expression in retinas from Rho-/-C129 mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, (Suppl. 2), 2004, ppU179 - U179 Meeting Abstract, 2004

Research Expertise


  • Title
    • Eye-D: Therapeutic target identification for degenerative eye disease
  • Summary
    • This project is focused on identifying the molecular cause of blindness including age related macular degeneration (AMD), glaucoma and inherited retinal diseases. It is an industry academic consortium and involves collaboration with Roche, Eli Lilly and Progressive Vision as well as a collaboration with the Irish charity Fighting Blindness Ireland.
  • Funding Agency
    • SFI
  • Date From
    • 1/11/2021
  • Date To
    • 31/10/2025
  • Title
    • Retina Rhythm:Investigating the role of the inner retina in age-related macular degeneration (AMD)
  • Summary
    • This is an ERC project focused on identifying the earliest causes of age related macular degeneration (AMD). The central hypothesis is that AMD is driven by a dysfunction of blood vessels in the inner retina and that regulating the integrity of these vessels may stabilise the condition.
  • Funding Agency
    • European Research Council
  • Date From
    • 1/7/2020
  • Date To
    • 30/6/2025


AGE-RELATED MACULOPATHY; Alzheimer's Disease; BLOOD-BRAIN-BARRIER; Cell signalling, proliferation & differentiation; Cellular Biology; ENDOTHELIAL CELLS; Genetics; INFLAMMATION; Molecular Biology; Molecular Genetics; Neurobiology; neurodegeneration; Neuroscience; siRNA technology; TIGHT JUNCTIONS; Transgenics; Vision



Member of the scientific review committee of Moorfields Eye Charity, UK. 2020 - present

Awards and Honours

Science Foundation Ireland, Young Researcher of the year 2020

European Research Council Consolidator Award 2020

Irish Research Council Laureate Award. 2018

Association for Ocular Pharmacology and Therapeutics, National Eye Institute (NEI) award 2015

Association for Research in Vision and Ophthalmology, NEI travel Award 2015

Genentech/ARVO fellowship in recognition of my research on AMD 2015

Science Foundation Ireland, President of Ireland Young Researcher Award (PIYRA) 2013

"Pro-Retina" travel award for XVth International Symposium on Retinal Degenerations 2012

Appointed Senior Research Fellow, TCD 2012

Roche Research Award, Smurfit Institute of Genetics 2010

Fighting Blindness Ireland Research Scholarship 2002


Associate Editor, Fluids and Barriers of the CNS 2021 – Present

Member of International Society for Eye Research. 2010-present: International Brain Barriers Society (IBBS). 2014 – Present