Paul Browne
Professor/Consultant Haematologist, Haematology

Publications and Further Research Outputs

Peer-Reviewed Publications

Giebel S, Labopin M, Socié G, Beelen D, Browne P, Volin L, Kyrcz-Kr Zemien S, Yakoub-Agha I, Aljurf M, Wu D, Michallet M, Arnold R, Mohty M, Nagler A, Improving results of allogeneic hematopoietic cell transplantation for adults with acute lymphoblastic leukemia in first complete remission: An analysis from the Acute Leukemia Working party of the European Society for Blood and Marrow Transplantation, Haematologica, 102, (1), 2017, p139 - 149 Journal Article, 2017 DOI URL

Elhassadi E, Flavin R, Browne P, Conneally E, Hayden P, Quinn F, Higgins E, Vandenberghe E, Transformed follicular lymphoma (tFL): consolidation therapy may improve survival, 2017, 1 - 7 Miscellaneous, 2017 DOI URL

Smyth L, Browne PV, Conneally E, Flynn C, Hayden P, Jeffers M, O'Brien D, Quinn F, Kelly J, Perera M, Crotty GM, Leahy M, Hennessy B, Jackson F, Ryan M, Vandenberghe E, Burkitt leukaemia/lymphoma: R-CODOX-M/R-IVAC remains gold standard treatment in BL., 2016 Journal Article, 2016

Lavin M, Brophy T.M, Rawley O, O'Sullivan J.M, Hayden P.J, Browne P.V, Ryan K, O'Connell N, O'Donnell J.S, Lenalidomide as a novel treatment for refractory acquired von Willebrand syndrome associated with monoclonal gammopathy, Journal of Thrombosis and Haemostasis, 14, (6), 2016, p1200 - 1205 Journal Article, 2016 URL DOI

Faller E, Chapman L, Enright H, Browne P, McHugh J, Desmond R, Immune thrombocytopenia purpura associated with multiple myeloma, Annals of Hematology, 95, (8), 2016, p1371 - 1372 Journal Article, 2016 URL DOI

Giebel S, Labopin M, Ibatici A, Browne P, Czerw T, Socie G, Unal A, Kyrcz-Krzemien S, Bacigalupo A, Goker H, Potter M, Furness C.L, McQuaker G, Beelen D, Milpied N, Campos A, Craddock C, Nagler A, Mohty M, Association of macroeconomic factors with nonrelapse mortality after allogeneic hematopoietic cell transplantation for adults with acute lymphoblastic leukemia: An analysis from the acute leukemia working party of the EBMT, Oncologist, 21, (3), 2016, p377 - 383 Journal Article, 2016 DOI URL

Baron F, Labopin M, Blaise D, Lopez-Corral L, Vigouroux S, Craddock C, Attal M, Jindra P, Goker H, Socié G, Chevallier P, Browne P, Sandstedt A, Duarte R.F, Nagler A, Mohty M, Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: A report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation, Bone Marrow Transplantation, 49, (3), 2014, p389 - 396 Journal Article, 2014 DOI URL

Hillmen P, Muus P, Röth A, Elebute MO, Risitano AM, Schrezenmeier H, Szer J, Browne P, Maciejewski JP, Schubert J, Urbano-Ispizua A, de Castro C, Socié G, Brodsky RA, Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria., British journal of haematology, 2013 Journal Article, 2013

Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46 Journal Article, 2013 DOI

Fahy CM, Fortune A, Quinn F, McMenamin ME, Browne PV, Langabeer S, McCarron S, Hayden P, Marren P, Ni Chonghaile M, Irvine AD, Vandenberghe E, Barnes L, Development of mycosis fungoides after bone marrow transplantation for chronic myeloid leukaemia; transmission from allogeneic donor., The British journal of dermatology, 2013 Journal Article, 2013

Langabeer SE, O'Brien D, McElligott AM, Lavin M, Browne PV, BRAF V600E-Negative Hairy Cell Leukaemia., Case reports in hematology, 2013, 2013, p513049 Journal Article, 2013

Nagler A, Labopin M, Shimoni A, Mufti GJ, Cornelissen JJ, Blaise D, Janssen JJ, Milpied N, Vindelov L, Petersen E, Gribben J, Bacigalupo A, Malm C, Niederwieser D, Socié GJ, Arnold R, Brown P, Goker H, Rocha V, Mohty M, Mobilized peripheral blood stem cells compared with bone marrow from HLA-identical siblings for reduced-intensity conditioning transplantation in acute myeloid leukemia in complete remission: a retrospective analysis from the Acute Leukemia Working Party of EBMT., European journal of haematology, 89, (3), 2012, p206-13 Journal Article, 2012

Langabeer SE, O'Brien D, Liptrot S, Flynn CM, Hayden PJ, Conneally E, Browne PV, Vandenberghe E, Correlation of the BRAF V600E mutation in hairy cell leukaemia with morphology, cytochemistry and immunophenotype., International journal of laboratory hematology, 34, (4), 2012, p417-21 Journal Article, 2012

Spyridonidis A, Labopin M, Schmid C, Volin L, Yakoub-Agha I, Stadler M, Milpied N, Socie G, Browne P, Lenhoff S, Sanz MA, Aljurf M, Mohty M, Rocha V, Outcomes and prognostic factors of adults with acute lymphoblastic leukemia who relapse after allogeneic hematopoietic cell transplantation. An analysis on behalf of the Acute Leukemia Working Party of EBMT., Leukemia, 26, (6), 2012, p1211-7 Journal Article, 2012

Langabeer SE, Quinn F, O'Brien D, McElligott AM, Kelly J, Browne PV, Vandenberghe E, Incidence of the BRAF V600E mutation in chronic lymphocytic leukaemia and prolymphocytic leukaemia., Leukemia research, 36, (4), 2012, p483-4 Journal Article, 2012

Morgan G, Johnsen HE, Goldschmidt H, Palumbo A, Cavo M, Sonneveld P, Miguel JS, Chim CS, Browne P, Einsele H, Waage A, Turesson I, Spencer A, Hajek R, Ludwig H, Hemminki K, Houlston R, MyelomA Genetics International Consortium., Leukemia & lymphoma, 53, (5), 2012, p796-800 Journal Article, 2012

Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM, PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells., British journal of cancer, 104, (2), 2011, p281-9 Journal Article, 2011

Fortune AF, Kelly K, Sargent J, O'Brien D, Quinn F, Chadwick N, Flynn C, Conneally E, Browne P, Crotty GM, Thornton P, Vandenberghe E, Large granular lymphocyte leukemia: natural history and response to treatment., Leukemia & lymphoma, 51, (5), 2010, p839-45 Journal Article, 2010

Hillmen P, Elebute M, Kelly R, Urbano-Ispizua A, Hill A, Rother RP, Khursigara G, Fu CL, Omine M, Browne P, Rosse W, Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria., American journal of hematology, 85, (8), 2010, p553-9 Journal Article, 2010

Haslam K, Chadwick N, Kelly J, Browne P, Vandenberghe E, Flynn C, Conneally E, Langabeer SE, Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia., Irish journal of medical science, 179, (4), 2010, p507-10 Journal Article, 2010

Ryan J, Quinn F, Meunier A, Boublikova L, Crampe M, Tewari P, O'Marcaigh A, Stallings R, Neat M, O'Meara A, Breatnach F, McCann S, Browne P, Smith O, Lawler M, Minimal residual disease detection in childhood acute lymphoblastic leukaemia patients at multiple time-points reveals high levels of concordance between molecular and immunophenotypic approaches., British journal of haematology, 144, (1), 2009, p107-15 Journal Article, 2009

McElligott, AM, Maginn, EN, Greene, LM, McGuckin, S, Hayat, A, Browne, PV, Butini, S, Campiani, G, Catherwood, MA, Vandenberghe, E, Williams, DC, Zisterer, DM, Lawler, M, The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia., Cancer Research, 69, (21), 2009, p8366 - 8375 Journal Article, 2009 DOI

Hayat A, McGuckin S, Conneally E, Brown PV, McCann SR, Lawler M, Quinn F, Delaney E, O'Rourke P, Liptrot S, O'Brien D, Vandenberghe E, Fludarabine, Cyclophosphamide and Rituximab: an effective chemoimmunotherapy combination with high remission rates for chronic lymphocytic leukaemia., Irish journal of medical science, 178, (4), 2009, p441-6 Journal Article, 2009

Bacon CL, Daly P, Sheane B, Conneally EC, Browne PV, McCann S, Ni Chongaile M, O'Brian DS, Mc Dermott R, Hollywood D, Wilson L, Vandenberghe E, Successful outcome of patients with relapsed/refractor Hodgkin lymphoma treated with high dose chemotherapy at the National Adult Bone Marrow Transplant Unit at St. James's Hospital., Irish medical journal, 102, (1), 2009, p26-8 Journal Article, 2009

Schubert J, Hillmen P, Röth A, Young NS, Elebute MO, Szer J, Gianfaldoni G, Socié G, Browne P, Geller R, Rother RP, Muus P, Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysmal nocturnal haemoglobinuria., British journal of haematology, 142, (2), 2008, p263-72 Journal Article, 2008

Hayden PJ, Tewari P, Morris DW, Staines A, Crowley D, Nieters A, Becker N, de Sanjosé S, Foretova L, Maynadié M, Cocco PL, Boffetta P, Brennan P, Chanock SJ, Browne PV, Lawler M, Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma., Human molecular genetics, 16, (24), 2007, p3117-27 Journal Article, 2007

Hayat A, O'Brien D, O'Rourke P, McGuckin S, Fitzgerald T, Conneally E, Browne PV, McCann SR, Lawler MP, Vandenberghe E, CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia., Leukemia & lymphoma, 47, (11), 2006, p2371-9 Journal Article, 2006

Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu CL, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L, The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria., The New England journal of medicine, 355, (12), 2006, p1233-43 Journal Article, 2006

Boublikova, L, Kalinova, M, Ryan, J, Quinn, F, O'Marcaigh, A, Smith, O, Browne, P, Stary, J, McCann, SR, Trka, J, Lawler, M, Wilms' tumor gene 1 (WT1) expression in childhood acute lymphoblastic leukemia: a wide range of WT1 expression levels, its impact on prognosis and minimal residual disease monitoring., Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 20, (2), 2006 Journal Article, 2006 DOI

O'Donghaile D, Hayden PJ, McCarron SL, Doyle EM, Lawler M, Browne PV, Conneally E, Vandenberghe E, McCann SR, Marrow aplasia developing 13 years after HLA-identical sibling allogeneic transplantation for chronic myeloid leukaemia: successful treatment with antithymocyte globulin and peripheral blood stem cell infusion from the original donor., European journal of haematology, 76, (3), 2006, p258-60 Journal Article, 2006

Hennessy B, McCaffrey JA, Daly P, Browne P, Kennedy MJ, High dose chemotherapy and stem cell support for poor risk and recurrent nonseminomatous germ cell cancer: initial experience with sequential therapy., Irish journal of medical science, 171, (3), 2005, p158-60 Journal Article, 2005

Hayden PJ, O'Driscoll A, Gardiner N, Swords R, Sargent J, Ni Ainle F, Fortune A, Murphy PT, Leahy M, Jackson F, Ryan M, Hennessy B, Cahill M, Crotty GM, Enright H, Conneally E, Vandenberghe E, McCann SR, Browne PV, Autologous stem cell transplantation in myeloma: the St James's Hospital experience, 1997-2003., Irish journal of medical science, 174, (2), 2005, p26-32 Journal Article, 2005

McCann S, Byrne JL, Rovira M, Shaw P, Ribaud P, Sica S, Volin L, Olavarria E, Mackinnon S, Trabasso P, VanLint MT, Ljungman P, Ward K, Browne P, Gratwohl A, Widmer AF, Cordonnier C, Outbreaks of infectious diseases in stem cell transplant units: a silent cause of death for patients and transplant programmes., Bone marrow transplantation, 33, (5), 2004, p519-29 Journal Article, 2004

O'Brien DA, Flynn CM, Chuk P, Gorman C, Wild B, Browne PV, Haemoglobin Etobicoke, an incidental finding in an Irish diabetic., Clinical and laboratory haematology, 25, (4), 2003, p259-62 Journal Article, 2003

Solovey AN, Gui L, Chang L, Enenstein J, Browne PV, Hebbel RP, Identification and functional assessment of endothelial P1H12., The Journal of laboratory and clinical medicine, 138, (5), 2001, p322-31 Journal Article, 2001

O'Connell N, Gardiner N, Duggan C, Enright H, Kennedy MJ, McCann SR, Daly PA, Browne PV, Effective progenitor cell mobilization in lymphoproliferative disorders using ifosfamide, epirubicin and etoposide (IEV)., European journal of haematology. Supplementum, 64, 2001, p33-6 Journal Article, 2001

Browne PV, Weisdorf DJ, DeFor T, Miller WJ, Davies SM, Filipovich A, McGlave PB, Ramsay NK, Wagner J, Enright H, Response to thalidomide therapy in refractory chronic graft-versus-host disease., Bone marrow transplantation, 26, (8), 2000, p865-9 Journal Article, 2000

Knowles S, Herra C, Devitt E, O'Brien A, Mulvihill E, McCann SR, Browne P, Kennedy MJ, Keane CT, An outbreak of multiply resistant Serratia marcescens: the importance of persistent carriage., Bone marrow transplantation, 25, (8), 2000, p873-7 Journal Article, 2000

Browne P, Shalev O, Hebbel RP, The molecular pathobiology of cell membrane iron: the sickle red cell as a model., Free radical biology & medicine, 24, (6), 1998, p1040-8 Journal Article, 1998

Verfaillie CM, Bhatia R, Browne P, Key NS, Interferon-alpha restores beta1-integrin-dependent, collagen-mediated platelet aggregation in a patient with chronic myelogenous leukemia., The Journal of laboratory and clinical medicine, 131, (2), 1998, p163-9 Journal Article, 1998

Browne PV, Shalev O, Kuypers FA, Brugnara C, Solovey A, Mohandas N, Schrier SL, Hebbel RP, Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia., The Journal of clinical investigation, 100, (6), 1997, p1459-64 Journal Article, 1997

Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP, Circulating activated endothelial cells in sickle cell anemia., The New England journal of medicine, 337, (22), 1997, p1584-90 Journal Article, 1997

Gupta K, Ramakrishnan S, Browne PV, Solovey A, Hebbel RP, A novel technique for culture of human dermal microvascular endothelial cells under either serum-free or serum-supplemented conditions: isolation by panning and stimulation with vascular endothelial growth factor., Experimental cell research, 230, (2), 1997, p244-51 Journal Article, 1997

Browne PV, Mosher DF, Steinberg MH, Hebbel RP, Disturbance of plasma and platelet thrombospondin levels in sickle cell disease., American journal of hematology, 51, (4), 1996, p296-301 Journal Article, 1996

Browne PV, Hebbel RP, CD36-positive stress reticulocytosis in sickle cell anemia., The Journal of laboratory and clinical medicine, 127, (4), 1996, p340-7 Journal Article, 1996

Maher J, Browne P, Daly L, McCann SR, Daly PA, A circadian distribution to febrile episodes in neutropenic patients., Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1, (2), 1993, p98-100 Journal Article, 1993

Browne PV, Lawler M, O'Riordan J, Humphries P, McCann SR, Early detection of leukaemic relapse after bone marrow transplantation using the polymerase chain reaction., Bone marrow transplantation, 7, (2), 1991, p167-9 Journal Article, 1991

Browne PV, Lawler M, Humphries P, McCann SR, Donor-cell leukemia after bone marrow transplantation for severe aplastic anemia., The New England journal of medicine, 325, (10), 1991, p710-3 Journal Article, 1991