Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search

Professor Maeve Caldwell
Professor in Neuroscience, Physiology
Professor in Neuroscience, Trinity Inst. of Neurosciences (TCIN)

Publications and Further Research Outputs

Peer-Reviewed Publications

Maughan, J. and Gouveia, P.J. and Gonzalez, J.G. and Leahy, L.M. and Woods, I. and O'Connor, C. and McGuire, T. and Garcia, J.R. and O†Shea, D.G. and McComish, S.F. and Kennedy, O.D. and Caldwell, M.A. and Dervan, A. and Coleman, J.N. and O'Brien, F.J., Collagen/pristine graphene as an electroconductive interface material for neuronal medical device applications, Applied Materials Today, 29, (101629), 2022 Journal Article, 2022 TARA - Full Text DOI

McComish S.F., MacMahon Copas A.N., Caldwell M.A., Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson"s Disease Research and Therapeutic Development, Frontiers in Neuroscience, 16, 2022 Journal Article, 2022 DOI

Crompton L.A., McComish S.F., Stathakos P., Cordero-Llana O., Lane J.D., Caldwell M.A., Efficient and scalable generation of human ventral midbrain astrocytes from human-induced pluripotent stem cells, Journal of Visualized Experiments, (176), 2021 Journal Article, 2021 DOI

Stathakos P., Jimenez-Moreno N., Crompton L.A., Nistor P.A., Badger J.L., Barbuti P.A., Kerrigan T.L., Randall A.D., Caldwell M.A., Lane J.D., A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons, Autophagy, 17, (4), 2021, p855 - 871, p855-871 Journal Article, 2021 DOI

MacMahon Copas AN, McComish SF, Fletcher JM, Caldwell MA., The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?, Frontiers in neurology, 12, 2021, p666737 Journal Article, 2021 DOI

Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Caldwell MA, Lane JD, Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research., Methods in molecular biology (Clifton, N.J.), 2019 Journal Article, 2019

Maeve A. Caldwell, Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes, Nature Nanotechnology, 13, 2018, p427 - 433 Journal Article, 2018 DOI

Sarah F. McComish, Maeve A. Caldwell, Generation of defined neural populations from pluripotent stem cells, Philosophical Transactions of the Royal Society B: Biological Sciences, 373, (1750), 2018, p20170214 Journal Article, 2018 DOI

Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells, 2018, pp3 - 20, [Maeve A. Caldwell] Book Chapter, 2018

Jiménez-Moreno N, Stathakos P, Caldwell MA, Lane JD, Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease., Cells, 2017 Journal Article, 2017 DOI

Crompton LA, Cordero-Llana O, Caldwell MA, Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders., Brain pathology (Zurich, Switzerland), 2017 Journal Article, 2017 DOI

McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA, Loss of MicroRNA-7 Regulation Leads to "-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo., Molecular therapy : the journal of the American Society of Gene Therapy, 2017 Journal Article, 2017 DOI

Zhu B, Caldwell M, Song B, Development of stem cell-based therapies for Parkinson's disease., The International journal of neuroscience, 2016 Journal Article, 2016 DOI

Wang W, Wang X, Fujioka H, Hoppel C, Whone AL, Caldwell MA, Cullen PJ, Liu J, Zhu X, Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes., Nature medicine, 2016 Journal Article, 2016 URL

Cordero-Llana Ó, Houghton BC, Rinaldi F, Taylor H, Yáñez-Muñoz RJ, Uney JB, Wong LF, Caldwell MA, Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease., Molecular therapy : the journal of the American Society of Gene Therapy, 2015 Journal Article, 2015

Damseh N, Danson CM, Al-Ashhab M, Abu-Libdeh B, Gallon M, Sharma K, Yaacov B, Coulthard E, Caldwell MA, Edvardson S, Cullen PJ, Elpeleg O, A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration., Neurogenetics, 2015 Journal Article, 2015

Nistor Paul A., May Paul W., Tamagnini Francesco, Randall Andrew D., Caldwell Maeve A., Long-term culture of pluripotent stem-cell-derived human neurons on diamonds" A substrate for neurodegeneration research and therapy , Biomaterials , 61 , ( ), 2015, p139 - 149 Journal Article, 2015 TARA - Full Text URL DOI

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ, Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation., Current biology : CB, 2014 Journal Article, 2014

Rinaldi F, Hartfield EM, Crompton LA, Badger JL, Glover CP, Kelly CM, Rosser AE, Uney JB, Caldwell MA, Cross-regulation of Connexin43 and ß-catenin influences differentiation of human neural progenitor cells., Cell death & disease, 2014 Journal Article, 2014

Cordero-Llana O, Rinaldi F, Brennan PA, Wynick D, Caldwell MA, Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain., Experimental neurology, 2014 Journal Article, 2014

Rinaldi F, Caldwell MA, Modeling astrocytic contribution toward neurodegeneration with pluripotent stem cells: focus on Alzheimer's and Parkinson's diseases., Neuroreport, 2013 Journal Article, 2013

Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA, Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling., Stem cell research, 2013 Journal Article, 2013

Höglinger GU, Barker RA, Hagg T, Arias-Carrión O, Caldwell MA, Hirsch EC, Quantitative evaluation of the human subventricular zone., Brain : a journal of neurology, 2012 Journal Article, 2012

Badger JL, Byrne ML, Veraitch FS, Mason C, Wall IB, Caldwell MA, Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts., Regenerative medicine, 2012 Journal Article, 2012

Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Case CP, Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness., Nature nanotechnology, 2011 Journal Article, 2011

Cordero-Llana O, Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Caldwell MA, Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells., Cell Death and Differentiation, 2011 Journal Article, 2011

Hartfield EM, Rinaldi F, Glover CP, Wong LF, Caldwell MA, Uney JB, Connexin 36 expression regulates neuronal differentiation from neural progenitor cells., PloS one, 2011 Journal Article, 2011

Barraud P, He X, Zhao C, Caldwell MA, Franklin RJ, FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures., Experimental cell research, 2010 Journal Article, 2010

Cogan N, Baird DM, Phillips R, Crompton LA, Caldwell MA, Rubio MA, Newson R, Lyng F, Case CP, DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase., Mutation research, 2010 Journal Article, 2010

Thomas M, Tyers P, Lazic SE, Caldwell MA, Barker RA, Beazley L, Ziman M, Graft outcomes influenced by co-expression of Pax7 in graft and host tissue., Journal of anatomy, 2009 Journal Article, 2009

O'Keeffe GC, Barker RA, Caldwell MA, Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain., Cell cycle (Georgetown, Tex.), 2009 Journal Article, 2009

Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB, Twist-1 regulates the miR-199a/214 cluster during development., Nucleic acids research, 2009 Journal Article, 2009

Kelly S, Caldwell M, Keasey MP, Cooke JA, Uney JB, Identifying neural progenitor cells in the adult brain., Methods in molecular biology (Clifton, N.J.), 2009 Journal Article, 2009

O'Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA, Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF., Proceedings of the National Academy of Sciences of the United States of America, 2009 Journal Article, 2009

Ormerod BK, Palmer TD, Caldwell MA, Neurodegeneration and cell replacement., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008 Journal Article, 2008

Hall PE, Lathia JD, Caldwell MA, Ffrench-Constant C, Laminin enhances the growth of human neural stem cells in defined culture media., BMC neuroscience, 2008 Journal Article, 2008

Barraud P, He X, Caldwell MA, Franklin RJ, Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures., BMC neuroscience, 2008 Journal Article, 2008

O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell MA, Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease., Brain : a journal of neurology, 2008 Journal Article, 2008

Chandran S, Caldwell M, Allen N, Introduction: stem cells and brain repair., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008 Journal Article, 2008

Prosser HM, Bradley A, Caldwell MA, Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation., The European journal of neuroscience, 2007 Journal Article, 2007

Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA, Rao MS, Mattson MP, ffrench-Constant C, Patterns of laminins and integrins in the embryonic ventricular zone of the CNS., The Journal of comparative neurology, 2007 Journal Article, 2007

Anderson L, Caldwell MA, Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease., Neurobiology of disease, 2007 Journal Article, 2007

Lim JC, Wolpaw AJ, Caldwell MA, Hladky SB, Barrand MA, Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells., Brain research, 2007 Journal Article, 2007

Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA, Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo., Experimental neurology, 2007 Journal Article, 2007

Barraud P, He X, Zhao C, Ibanez C, Raha-Chowdhury R, Caldwell MA, Franklin RJ, Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells., The European journal of neuroscience, 2007 Journal Article, 2007

Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S, Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells., Brain : a journal of neurology, 2007 Journal Article, 2007

Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C, Integrins are markers of human neural stem cells., Stem cells (Dayton, Ohio), 2006 Journal Article, 2006

Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S, Astrocytes promote neurogenesis from oligodendrocyte precursor cells., The European journal of neuroscience, 2006 Journal Article, 2006

Joannides A, Fiore-Hériché C, Westmore K, Caldwell M, Compston A, Allen N, Chandran S, Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion., Stem cells (Dayton, Ohio), 2006 Journal Article, 2006

Caldwell MA, He X, Svendsen CN, 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro., The European journal of neuroscience, 2005 Journal Article, 2005

Watts C, McConkey H, Anderson L, Caldwell M, Anatomical perspectives on adult neural stem cells., Journal of anatomy, 2005 Journal Article, 2005

Strappe PM, Hampton DW, Brown D, Cachon-Gonzalez B, Caldwell M, Fawcett JW, Lever AM, Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage., Retrovirology, 2005 Journal Article, 2005

Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN, Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF., Experimental neurology, 2004 Journal Article, 2004

Le Belle JE, Caldwell MA, Svendsen CN, Improving the survival of human CNS precursor-derived neurons after transplantation., Journal of neuroscience research, 2004 Journal Article, 2004

Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA, Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease., The international journal of biochemistry & cell biology, 2004 Journal Article, 2004

Lewis SJ, Caldwell MA, Barker RA, Modern therapeutic approaches in Parkinson's disease., Expert reviews in molecular medicine, 2003 Journal Article, 2003

Barker RA, Jain M, Armstrong RJ, Caldwell MA, Stem cells and neurological disease., Journal of neurology, neurosurgery, and psychiatry, 2003 Journal Article, 2003

Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN, Gene expression in human neural stem cells: effects of leukemia inhibitory factor., Journal of neurochemistry, 2003 Journal Article, 2003

Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P, Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study., Lancet (London, England), 2002 Journal Article, 2002

Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN, Regional specification of rodent and human neurospheres., Brain research. Developmental brain research, 2002 Journal Article, 2002

Caldwell MA, Recent advances in neuralstem cell technologies., Trends in neurosciences, 2001 Journal Article, 2001

Caldwell MA, He X, Wilkie N, Pollack S, Marshall G, Wafford KA, Svendsen CN, Growth factors regulate the survival and fate of cells derived from human neurospheres., Nature biotechnology, 2001 Journal Article, 2001

Svendsen CN, Caldwell MA, Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation., Progress in brain research, 2000 Journal Article, 2000

Besret L, Caldwell MA, Torres EM, Dunnett SB, Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats., European journal of pharmacology, 2000 Journal Article, 2000

Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, Svendsen CN, Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation., Experimental neurology, 2000 Journal Article, 2000

Ostenfeld T, Horn P, Aardal C, Orpen I, Caldwell MA, Svendsen CN, Mouse epidermal growth factor-responsive neural precursor cells increase the survival and functional capacity of embryonic rat dopamine neurons in vitro., Neuroreport, 1999 Journal Article, 1999

Svendsen CN, Caldwell MA, Ostenfeld T, Human neural stem cells: isolation, expansion and transplantation., Brain pathology (Zurich, Switzerland), 1999 Journal Article, 1999

Caldwell MA, Svendsen CN, Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells., Experimental neurology, 1998 Journal Article, 1998

Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA, A new method for the rapid and long term growth of human neural precursor cells., Journal of neuroscience methods, 1998 Journal Article, 1998

Watts C, Caldwell MA, Dunnett SB, The development of intracerebral cell-suspension implants is influenced by the grafting medium., Cell transplantation, 1998 Journal Article, 1998

Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P, Karmiol S, Dunnett SB, Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease., Experimental neurology, 1997 Journal Article, 1997

Caldwell MA, Reymann JM, Allain H, Leonard BE, Bentué-Ferrer D, Lisuride prevents learning and memory impairment and attenuates the increase in extracellular dopamine induced by transient global cerebral ischemia in rats., Brain research, 1997 Journal Article, 1997

Earley B, Canney M, Clune B, Caldwell M, Leonard BE, Junien JL, The effects of MK-801, ifenprodil, JO 1784, JO 1994 and JO 1997 on PK 11195 receptor binding, nitric oxide synthase (NO synthase) activity and infarct volume in a mouse model of focal cerebral ischaemia., Neurochemistry international, 1996 Journal Article, 1996

Caldwell MA, Reymann JM, Bentue-Ferrer D, Allain H, Leonard BE, The dopamine agonists lisuride and piribedil protect against behavioural and histological changes following 4-vessel occlusion in the rat., Neuropsychobiology, 1996 Journal Article, 1996

O'Neill M, Caldwell M, Earley B, Canney M, O'Halloran A, Kelly J, Leonard BE, Junien JL, The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia., European journal of pharmacology, 1995 Journal Article, 1995

Caldwell M, O'Neill M, Earley B, Kelly JP, Leonard BE, NG-nitro-L-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia., European journal of pharmacology, 1995 Journal Article, 1995

Maginn M, Caldwell M, Kelly JP, Leonard BE, The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia., European journal of pharmacology, 1995 Journal Article, 1995

Caldwell M, O'Neill M, Earley B, Leonard B, NG-Nitro-L-arginine protects against ischaemia-induced increases in nitric oxide and hippocampal neuro-degeneration in the gerbil., European journal of pharmacology, 1994 Journal Article, 1994

Non-Peer-Reviewed Publications

Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells , 2018, pp3 - 20, [Maeve A. Caldwell] Book Chapter, 2018 DOI

Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells, 2018, pp3 - 20, [Maeve A. Caldwell] Book Chapter, 2018 DOI

Research Expertise


  • Title
    • Examining the interplay of the immune system with brain cells in Parkinson's disease
  • Summary
    • Age is the primary risk factor for the development of a neurodegenerative disease such as Parkinson's disease with projected disease burden expected to increase 2-fold in Ireland by 2036. The overall burden is likely to keep increasing unless mechanistic based strategies for alleviating this age related neural decline are discovered and exploited for prevention or therapy. The potential role of the astrocytes as either a cellular target or as a secondary participant in the pathogenesis of neurodegenerative disease has gained attention in recent years as has the role of the immune system. However, our understanding of astrocytic mechanisms in response to stress/injury is incomplete compared to that of neurons and our understanding of the role the immune system plays is still in its infancy. The aim of this project is to determine the interplay between T cells (specifically Th17 cells) and astrocytes and how either cell type alone or following stimulation of the astrocytes with microglial secreted factors affects the survival of midbrain dopamine neurons. We will generate midbrain dopamine neurons and midbrain astrocytes from a number of induced pluripotent stem cell lines, including idiopathic Parkinson's and normal controls and we will isolate Th17 lymphocytes from whole blood of Parkinson's patients and controls. In addition, we will utilise Mass Spectroscopy to determine what factors are secreted by astrocytes. Specifically we will collect astrocyte conditioned media before and after their exposure to Th17 cells or microglial secreted factors and determine what factors are detrimental to dopamine neuronal survival. This body of work will determine how the interplay of the immune system with cells of the brain is implicated in the pathogenesis of Parkinson's disease
  • Funding Agency
    • HRB
  • Date From
    • 01/04/2020
  • Date To
    • 31/01/2024
  • Title
    • Apolipoprotein-E genotype influences inflammation in Alzheimer's Disease
  • Funding Agency
    • SFI
  • Date From
    • 01/10/2020
  • Date To
    • 31/09/2024
  • Title
    • PARKIE: Parkinson's community Awareness of Research; emphasis on Knowledge and Information Exchange
  • Funding Agency
    • HRB
  • Date From
    • 01/11/2022
  • Date To
    • 31/10/2023