The School of Pharmacy and Pharmaceutical Sciences

Contact Us The School of Pharmacy & Pharmaceutical Sciences
Panoz Institute
Trinity College Dublin
The University of Dublin
Dublin 2
Ireland
D02VF25

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pharmacy@tcd.ie
Dr. John Walsh

Dr. John Walsh

Associate Professor, Pharmacy

3531896 2806http://people.tcd.ie/jjwalsh

Biography

John J. Walsh, BA (Mod.), PhD (TCD), is an Associate Professor of Pharmacognosy and Associate Director of the NatPro Centre for Natural Product Research in Trinity College Dublin. A particular theme of his research is the evaluation of plant-based metabolites for potential use in the treatment of inflammatory conditions, microbial and insect-related infections, allergies and cancer. In parallel, he also runs drug design based projects with particular emphasis on the design, synthesis and evaluation of hybrid-based compounds and designed multiple ligands as potential therapies for both malaria and cancer. As Senior Author he has published widely across many of the leading journals in his field. including Journal of Natural Products, European Journal of Medicinal Chemistry, British Journal of Pharmacology, Bioorganic and Medicinal Chemistry, Angiogenesis, Current Pharmaceutical Design, Pharmaceutical Research, Current Medicinal Chemistry, Pharmaceutics and Chemical Communications. Funding for his research has been secured from Enterprise Ireland, Cancer Research Ireland, Research Ireland, Higher Education Authority and Department of Justice, Ireland. As principal supervisor he has supervised 20 PhD and 4 MSc students to completion. He is a very strong advocate of research-led teaching and has published eight papers in the Journal of Chemical Education on miniaturised and sustainable methods for the isolation of medicinally important natural products. He is a former Director of Undergraduate Teaching and Learning in the School of Pharmacy and Pharmaceutical Sciences and is currently a member of Committee 13B (Phytochemistry) of the European Pharmacopoeia.

Publications and Further Research Outputs

  • Zhang T, Finn D.F, Barlow J.W, Walsh J.J, Mast cell stabilisers, European Journal of Pharmacology, 778, 2016, p158 - 168Journal Article, 2016, DOI , URL
  • Egan M, Connors E.M, Anwar Z, Walsh J.J, Nature's Treatment for Irritable Bowel Syndrome: Studies on the Isolation of (-)-Menthol from Peppermint Oil and Its Conversion to (-)-Menthyl Acetate, Journal of Chemical Education, 92, (10), 2015, p1736 - 1740Journal Article, 2015, DOI , URL
  • Brian Moran, The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents (PhD Thesis), Trinity College Dublin, 2015Thesis, 2015, URL
  • Denise Ropero, Phytochemical studies on Choisya x dewitteana 'Aztec Pearl', 2018Thesis, 2018
  • Ijaz S, Shoaib Khan HM, Anwar Z, Talbot B, Walsh JJ, HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential, Biomedicine & Pharmacotherapy, 109, 2019, p865 - 875Journal Article, 2019, DOI , URL , TARA - Full Text
  • G. Sturman(ed.), NOVEL MAST CELL-STABILISING ALCOHOLDERIVATIVES OF 3,4 DIHYDRONAPHTHALEN-1(2H)-ONE and 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE, Inflammation Research, Malaga, Spain, 64, (Suppl 1), May 6-9, 2015, 2015, 15 - 15 pProceedings of a Conference, 2015
  • Zeeshan Anwar, Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties, Trinity College Dublin, 2019Thesis, 2019, URL
  • Ryan, T.J.; Grimes, T.; Henman, M.C.; Sheachnasaigh, E.N.; O'Dwyer, M.; Roche, C.; Ryder, S.A.; Sasse, A.; Walsh, J.J. & D'Arcy, D.M, Design and Implementation of an Integrated Competency-Focused Pharmacy Programme: A Case Report., Pharmacy, 7, (3), 2019Journal Article, 2019, DOI , URL
  • Ryan TJ, Ryder SA, D'Arcy DM, Quigley JM, Ng NN, Ong WQ, Tey ZH, O'Dwyer M, Walsh JJ., Development of Professional Attributes through Integration of Science and Practice at First-Year Pharmacy Level, Pharmacy, 2021Journal Article, 2021, DOI , URL , TARA - Full Text
  • Doyle AM, Reilly J, Murphy N, Kavanagh PV, O'Brien JE, Walsh MS, Walsh JJ, Nature's sedative: Isolation and structural elucidation of valtrate from Centranthus ruber, Journal Of Chemical Education, 81, (10), 2004, p1486 - 1487Journal Article, 2004, DOI , URL
  • Mills C, Cleary BJ, Gilmer JF, Walsh JJ, Inhibition of acetylcholinesterase by Tea Tree oil, Journal Of Pharmacy and Pharmacology, 56, (3), 2004, p375 - 379Journal Article, 2004, DOI , URL
  • Cunningham D, Grayson DH, McArdle P, Walsh JJ, The bromination of (-)-camphorquinone, Tetrahedron-Asymmetry, 14, (9), 2003, p1197 - 1200Journal Article, 2003, DOI , URL
  • Carolan JC, Hook ILI, Walsh JJ, Hodkinson TR, Using AFLP markers for species differentiation and assessment of genetic variability of in vitro-cultured Papaver bracteatum (section Oxytona), In Vitro Cellular & Developmental Biology-Plant, 38, (3), 2002, p300 - 307Journal Article, 2002, DOI , URL
  • Anwar N, Khan A, Shah M​, Walsh JJ, Saleem S, Anwar Z, Aslam S, Irshad M., Hybridization of green synthesized silver nanoparticles with poly(ethylene glycol) methacrylate and their biomedical applications., PeerJ , (10), 2022, p1 - 28Journal Article, 2022, DOI
  • A.L. Simplício, J.F. Gilmer, N. Frankish, H. Sheridan, J.J. Walsh and J.M. Clancy, Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1-2), 2004, p233 - 238Journal Article, 2004, DOI
  • Simplício AL, Gilmer JF, Frankish N, Sheridan H, Walsh JJ, Clancy JM., Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1/2), 2004, p233 - 238Journal Article, 2004, URL
  • Quanxiang Yan, Tao Zhang, Christine O'Connor, James W. Barlow, John Walsh, Gaia Scalabrino, Feng Xu, Helen Sheridan, The biological responses of vitamin K2: A comprehensive review, Food Science & Nutrition, 00, 2023, p1 - 23Journal Article, 2023
  • Collyer, Samuel E., Gary D. Stack, and John J. Walsh, Selective Delivery of Clinically Approved Tubulin Binding Agents through Covalent Conjugation to an Active Targeting Moiety, CURRENT MEDICINAL CHEMISTRY, 29, (31), 2022, p5179 - 5211Journal Article, 2022, DOI
  • MJ Lyons, C Ehrhardt, JJ Walsh, Orellanine: From fungal origins to a future cancer treatment, J Nat Prod, 86, (6), 2023, p620-1631Journal Article, 2023, DOI , URL
  • Erol, Ã-zlem and Nagar, Shipra and Selo, Mohammed Ali and Obaidi, Ismael and Walsh, John J. and Sheridan, Helen and Choi, Young Hae, Identification of anti-inflammatory and antimicrobial compounds from leaves and rhizome of Iris pseudacorus collected in Ireland bogland using chemical profiling techniques, Fitoterapia, 185, 2025Journal Article, 2025, DOI , URL
  • Jabal, Khadijah A. and Pigott, Maria and Sheridan, Helen and Walsh, John J., Mediterranean Basin Erica Species: Traditional Uses, Phytochemistry and Pharmacological Properties, Molecules, 30, (12), 2025Journal Article, 2025, DOI , URL
  • Whyms SE, Sheridan H, Walsh JJ, Design Considerations for Essential Oil Formulations: Emulsification, Encapsulation and Stabilisation Strategies, Pharmaceutics, 18, (8), 2026, p953 - 995Journal Article, 2026, DOI
  • Mark J. Lyons, Brendan Twamley, John J. Walsh, CCDC 2554447: Experimental Crystal Structure Determination, Cambridge Crystallographic Data Centre, 2026Dataset, 2026, DOI
  • Ronan R. McCarthy, Kavita Gadar, John Walsh, Wildflower once used to treat wounds and sore throats shows promise in fighting dangerous superbugs, The Conversation, 2026Journal Article, 2026, DOI
  • , A study on the antiproliferative activity of the triterpenoid constituents in Erica erigena, 69, 2025, pp103623-103623Meeting Abstract, 2025, DOI
  • Minchao Guo, Muhammad Waleed Baig, Shane Carney, Ferdia O'Malley, Joshua Odidison, Amirul Helmi Idris, Stacey Li Hi Shing, John O'Brien, James W. Barlow, John Walsh, Studies on the Isolation and Structure Elucidation of Berberine, (")-ß-Hydrastine, and Jatrorrhizine from Goldenseal Root (Hydrastis canadensis L.) and Mahonia x media `Winter Sun" Stem Bark, Journal of Chemical Education, 102, (4), 2025, p1643 - 1650, p1643-1650Journal Article, 2025, DOI
  • Herng Mak, John Walsh, Short Lecture Where nature's toxins meet biologics: digital teaching of antibody-drug conjugates", 89, (14), 2023, pp1300 - 1300, pp1300-1300Oral Presentation, 2023, DOI
  • (ed.), A study on the triterpenoid constituents in Erica Erigena, 89, (14), 2023, 1326 - 1326 p, 1326-1326 pProceedings of a Conference, 2023, DOI
  • Natasha Anwar, Abbas Khan, Mohib Shah, John Walsh, Zeeshan Anwar, Hybridization of Gold Nanoparticles with Poly(ethylene glycol) Methacrylate and Their Biomedical Applications, Russian Journal of Physical Chemistry A, 95, (13), 2021, p2619 - 2631, p2619-2631Journal Article, 2021, DOI
  • (ed.), Aromatic Substitution Reaction of Ergothioneine; a Novel Mechanism of Xenobiotic Deactivation, 31, (S1), 2017Proceedings of a Conference, 2017, DOI
  • , Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo, 30, (S1), 2016Published Abstract, 2016, DOI
  • (ed.), OCTN1"Mediated Ergothioneine Uptake Protects Lung Epithelial Cells From Tobacco Smoke"Induced Damage, 29, (S1), 2015Proceedings of a Conference, 2015, DOI
  • James W. Barlow, Tao Zhang, Orla Woods, Adam J. Byrne, John Walsh, Novel Mast Cell-Stabilising Amine Derivatives of 3,4-Dihydronaphthalen-1(2H)-one and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-one, Medicinal Chemistry, 7, (3), 2011, p213 - 223, p213-223Journal Article, 2011, DOI
  • Ellen C. Breen, John Walsh, Tubulin-Targeting Agents in Hybrid Drugs, Current Medicinal Chemistry, 17, (7), 2010, p609 - 639, p609-639Journal Article, 2010, DOI
  • Gary Stack, Stereoselective synthesis of novel tubulin inhibitors with diverse functionality for integration into molecular conjugates and designed multiple ligands (Ph.D. Thesis), Trinity College Dublin, 2023Thesis, 2023, URL
  • Gillian Hudson, Design, synthesis and evaluation of novel tumour vasculature-targeting agents (PhD Thesis), 2007Thesis, 2007, URL
  • Khadijah Jabal, Phytochemical studies on Lusitanian heath species and their effects on angiogenesis and melanogenesis (PhD Thesis), Trinity College Dublin, 2026Thesis, 2026, URL
  • Mark Lyons, Optimisation of analytical, biological, and synthetic methods relevant to the pre-clinical development of orellanine as a targeted therapeutic for renal cell carcinoma (PhD Thesis), Trinity College Dublin, 2026Thesis, 2026, URL
  • Emmet McCormack, Design, synthesis and in vitro evaluation of novel anti-cancer compounds (PhD Thesis), 2003Thesis, 2003, URL
  • Kavita Gadar; Maria Pigott; Cillian Jacques Gately; Ismael Obaidi; Shipra Nagar; John J. Walsh; Helen Sheridan; Ronan R McCarthy, Bogland plant Tormentil inhibits multidrug-resistant pathogen growth and potentiates antibiotics by disrupting iron homeostasis, Microbiology (Reading), 172, (3), 2026, p1 - 14Journal Article, 2026, DOI
  • Richard Shah, The design and synthesis of novel inhibitors of tubulin polymerisation (Ph.D. Thesis), 2003Thesis, 2003, URL
  • Nagar, S., Pigott, M., Kukula-Koch, W., Sheridan, H., & Walsh, J., NMR Data of Lichenic Acids From Irish Cladonia Portentosa, nmrXiv, 2026Dataset, 2026, URL
  • Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A., A Novel Artemisinin-Quinine Hybrid with Potent Antimalarial Activity., Bioorganic and Medicinal Chemistry Letters, 17, (13), 2007, p3599 - 3602Journal Article, 2007, DOI , URL
  • Sheridan H, Butterly S, Walsh JJ, Cogan C, Jordan M, Nolan O, Frankish N, Synthesis and pharmacological activity of aminoindanone dimers and related compounds, Bioorganic and Medicinal Chemistry, 16, (1), 2008, p248 - 254Journal Article, 2008, DOI , URL
  • Davis AP, Walsh JJ, Amide bond formation via pentafluorothiophenyl active esters, Tetrahedron Letters, 35, (27), 1994, p4865 - 4868Journal Article, 1994, DOI , URL
  • Davis AP, Menzer S, Walsh JJ. , Steroid-based receptors with tunable cavities; A series of polyhydroxylated macrocycles of varying size and flexibility, Chemical Communications , 1996, p453 - 456Journal Article, 1996, URL
  • Davis AP, Walsh JJ., Steroid-based receptors with tunable cavities; Stepwise and direct syntheses of a C-3-symmetrical prototype, Chemical Communications, 1996, p449 - 451Journal Article, 1996, URL
  • Walsh JJ, Hook I, Kavanagh P, Reininger R., Naphthoquinone production by cultures of cape sundew (Drosera capensis), Pharmacy/Pharmacoloy Letters, 7, 1997, p93 - 95Journal Article, 1997
  • Comey N, Hook I, Sheridan H, Walsh J, James P., Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl-4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal of Natural Products., 60, (2), 1997, p148 - 148-149Journal Article, 1997, URL
  • Walsh JJ, Walsh MS, Ni Bhrangain S, Kavanagh PV and Feely J, Red Valerian-Nature's Sedative, Irish Journal of Medical Science, 168, (141), 1999, p143-Journal Article, 1999
  • Walsh JJ, Frankish NF, Sheridan H, Byrne W. Farrell R, Indane dimer compounds and their pharmaceutical use, 2001, US6300376Patent, 2001
  • Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2001, US6297399Patent, 2001
  • Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752Patent, 2002
  • Walsh JJ, Frankish NF, Sheridan H, Byrne W, Jordan M, Indane compounds and their pharmaceutical use, 2002, US6433021Patent, 2002
  • Walsh JJ, McCormack EM, Shah R, Endothelium as a target in the design of novel tumour vasculature targeting agents, Anticancer Research: Special edition, 24, 2004, p527 - 528Journal Article, 2004
  • Douglas RH, Muldowney CA, Mohamed R, Keohane F, Shanahan C, Kavanagh PV, Walsh JJ, Detection and quantification of valerenic acid in commercially available valerian products, Journal of Chemical Education, 84, (5), 2007, p829 - 831Journal Article, 2007, DOI , URL
  • Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A, A novel artemisinin-quinine hybrid with potent antimalarial activity, Bioorganic and Medicinal Chemistry Letters, 17, (13), 2007, p3599 - 3602Journal Article, 2007, URL
  • Walsh JJ, Treacy S, Dunne A, Kavanagh PV, A Simple Method For The Identification of Common Herbal/Alternative health products by Gas Chromatography/Mass Spectrometry, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp334-Meeting Abstract, 2006
  • Kavanagh PV, McCarthy S, Walsh JJ, Identification and quantitation of lovastatin in red yeast rice, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp335-Meeting Abstract, 2006
  • White M, Walsh JJ., Sodium Azide: A mild and selective deprotecting reagent for use in the synthesis of novel inhibitors of endothelial cell proliferation, Fifth interdisciplinary euroconference on angiogenesis, Sitges, Spain , May 27-30, 2005, pp114-Meeting Abstract, 2005
  • Byrne A, Walsh JJ, Studies on the Mast cell stabilising properties of plant extracts with reputed anti-inflammatory activity, 34th meeting of the European histamine research society, Bled, Slovenia, 2005 May 11-14, 2005, pp7-Meeting Abstract, 2005
  • Byrne A, Donnelly C, Mills C, Walsh JJ, A study on the mast cell stabilising properties of Sargentodoxa cuneata, 33rd annual meeting of theEuropean histamine research society, Düsseldorf / Köln, Germany, Apr 28-May2, 2004, pp29-Meeting Abstract, 2004
  • Screening for aminopeptidase inhibitors using silica gel thin layer chromatography, Hudson GJ, Ryan EP, Walsh JJ, British Microcirculation Society, 41st Scientific meeting and symposium: Tumour microcirculation: Development and Therapeutic targets, Sheffield, Apr 5-6, 2004, pp37-Meeting Abstract, 2004
  • Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A., A novel artemisinin-quinine hybrid with antimalarial activity., 11th International Congress of Parasitology, Glasgow, Aug, 2006Meeting Abstract, 2006
  • Barlow JW, Walsh JJ, Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds, European Journal of Medicinal Chemistry, 43, (12), 2008, p2891 - 2900Journal Article, 2008, DOI , URL
  • Walsh JJ and Bell A, Hybrid Drugs for Malaria, Current Pharmaceutical Design, 15(25), 2009, p2970-85Journal Article, 2009, DOI , URL
  • Comey N, Hook I, Sheridan H, Walsh J. , Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl - 4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal Of Natural Products (Lloydia) , 60, (2), 1997, p148-149Journal Article, 1997, DOI
  • Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930Journal Article, 2009, DOI
  • Breen EC and Walsh JJ, Tubulin-targeting agents in hybrid drugs., Current Medicinal Chemistry, 17, (7), 2010, p609 - 639Journal Article, 2010, URL
  • Sheridan H, Walsh JJ, Jordan M, Cogan C, Frankish N., A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties., European Journal of Medicinal Chemistry, 44, (12), 2009, p5018 - 5022Journal Article, 2009, URL
  • Barlow JW, Walsh JJ., Synthesis and evaluation of dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity., European Journal of Medicinal Chemistry, 45, (1), 2010, p25 - 37Journal Article, 2010, DOI , URL
  • O'Byrne PM, Williams R, Walsh JJ, Gilmer JF., The aqueous stability of bupropion, Journal of Pharmaceutical and Biomedical Analysis, 53, (3), 2010, p376 - 381Journal Article, 2010, DOI , URL
  • Adam J. Byrne, James W. Barlow, John J. Walsh, Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent, Bioorganic & Medicinal Chemistry Letters, 21, (4), 2011, p1191-1194Journal Article, 2011, DOI , URL , TARA - Full Text
  • James W. Barlow, Aengus P. McHugh, Orla Woods, John J. Walsh, Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds, European Journal of Medicinal Chemistry, 46, (5), 2011, p1545-1554Journal Article, 2011, DOI , URL , TARA - Full Text
  • Catherine M. Halpin, Ciara Reilly, and John J. Walsh, Nature's Anti-Alzheimer's Drug: Isolation and Structure Elucidation of Galantamine from Leucojum aestivum, Journal of Chemical Education, 87 , (11), 2010, p1242 - 1243Journal Article, 2010, DOI , URL
  • Sheridan, H. Walsh, J. J. Jordan, M. Cogan, C. Frankish, N, A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties, Eur J Med Chem, 44, (12), 2009, p5018-22Journal Article, 2009, DOI
  • Gary D. Stack and John J. Walsh, Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation., Pharmaceutical Research, 29, (11), 2012, p2972 - 2984Journal Article, 2012, URL
  • Anne-Marie Carroll, David J. Kavanagh, Fiona P. McGovern, Joe W. Reilly, and John J. Walsh, Nature's Chiral Catalyst and Anti-Malarial Agent: Isolation and Structure Elucidation of Cinchonine and Quinine from Cinchona calisaya, Journal of Chemical Education, 89, 2012, p1578 - 1581Journal Article, 2012, URL
  • Maisarah Mohd Nazri, Farah D. Samat, Pierce V. Kavanagh, and John J. Walsh, Nature's Cholesterol-Lowering Drug: Isolation and Structure Elucidation of Lovastatin from Red Yeast Rice-Containing Dietary Supplements, Journal of Chemical Education, 89, 2012, p138 - 140Journal Article, 2012, DOI , URL
  • Emma L. Walsh, Siobhan Ashe, and John J. Walsh, Nature's Migraine Treatment: Isolation and Structure Elucidation of Parthenolide from Tanacetum parthenium, Journal of Chemical Education, 89, 2012, p134 - 137Journal Article, 2012, DOI , URL
  • Prokopiou EM, Ryder SA, Walsh JJ, Tumour vasculature targeting agents in hybrid/conjugate drugs., Angiogenesis, 16, (3), 2013, p503 - 524Journal Article, 2013, DOI , URL , TARA - Full Text
  • Finn, D.F., Walsh, J.J., Twenty-first century mast cell stabilizers, British Journal of Pharmacology, 170, (1), 2013, p23-37Journal Article, 2013, DOI , TARA - Full Text
  • Carroll, A.-M., Kavanagh, D.J., McGovern, F.P., Reilly, J.W., Walsh, J.J., Natures chiral catalyst and anti-malarial agent: Isolation and structure elucidation of cinchonine and quinine from cinchona calisaya, Journal of Chemical Education, 89, (12), 2012, p1578-1581Journal Article, 2012, DOI
  • Linker technologies and release mechanisms for antibody-drug conjugates in, editor(s)Professor Norbert Sewald , Optimizing antibody-drug conjugates for targeted delivery of therapeutics, Future press, 2015, pp40 - 55, [John J. Walsh and Gary D. Stack ]Book Chapter, 2015, DOI
  • Bopha Chrea, Juliette A. O'Connell, Orlando Silkstone-Carter, John O'Brien, and John J. Walsh, Nature's Antidepressant for Mild to Moderate Depression: Isolation and Spectral Characterization of Hyperforin from a Standardized Extract of St. John's Wort (Hypericum perforatum), Journal of Chemical Education, 91, (3), 2014, p440 - 442Journal Article, 2014, DOI , URL
  • Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion, Pharmaceuticals, 7, (5), 2014, p595 - 620Journal Article, 2014, DOI , TARA - Full Text
  • Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug, Pharmaceuticals, 7, (6), 2014, p676 - 694Journal Article, 2014, DOI , TARA - Full Text
  • C Ehrhardt, S Nickel, MA Selo, CG Clerkin, JJ Salomon, B Talbot, JJ Walsh, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, FASEB J, Experimental Biology Meeting 2015, Boston, MA, 28/03-01/04/2015, 29, 2015, pp970.7Meeting Abstract
  • CG Clerkin, M Matzinger, MA Selo, BN Talbot, JJ Walsh, C Ehrhardt, Nucleophilic substitution reactions of ergothioneine might be a novel xenobiotic deactivation mechanism, 32nd Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 29/11-01/12/2017, 2017Oral Presentation
  • O'Dwyer M, Ryan T, Ryder S, D'Arcy DM, Walsh J. , Innovative Development and Evaluation of Professional Attributes through Integration of Science and Practice at First Year Pharmacy Level , Irish Network of Healthcare Educators Conference, TBSI, Trinity College Dublin, Dublin, Ireland , February 2020, 2020Oral Presentation
  • Whyms SE, Nagar S, Luker HA, Lopez AD, Pigott M, Hodkinson TR, Sheridan H, Hansen IA & Walsh JJ, Repellent activity against Aedes aegypti and metabolomic profiling of Myrica gale L. essential oils from Irish boglands, Scientific Reports, 2026, phttps://doi.org/10.1038/s41598Journal Article, DOI , URL
  • Tao Zhang, The synthesis of novel mast cell stabilisers from benzocycloalkanones (Ph.D. Thesis)), Trinity College Dublin, 2010Thesis, URL
  • Adrian Coogan, Design and synthesis of tubulin-binding agents, and their incorporation into novel dual-acting hybrid molecules targeting the tumour vasculature (Ph.D. Thesis), 2013Thesis, URL
  • Elaine Breen, The design, synthesis and preliminary evaluation of prodrugs and hybrid drugs with tubulin polymerisation inhibitory activity and anti-proliferative activity (Ph.D. Thesis), 2013Thesis, URL
  • Samuel Collyer, Design and Synthesis of Potent and Selective Anticancer Compounds Targeting Tubulin Polymerisation and Aminopeptidase N (Ph.D. Thesis), 2025Thesis, URL
  • Paul O'Byrne, Pharmaceutical stability and prodrug studies on the antidepressant bupropion (Ph.D Thesis), 2010Thesis, URL
  • James Barlow, Synthesis and pharmacological studies on a novel series of mast cell-stabilising tetrahydronaphthalenes and related compounds (Ph.D. Thesis), 2003Thesis, URL
  • Deirdre Finn, Studies on the design, synthesis and stability of novel anti-allergy agents, 2012Thesis, URL
  • Ekatherine M. Prokopiou, Preclinical evaluation of novel tumour vasculature disrupting agents (Ph.D. Thesis), 2013Thesis, URL
  • Neil Frankish, Helen Sheridan, John Walsh, Michael Jordan,, 'Indane compounds and their pharmaceutical use', N/A, US 6,433,021 B1, 2002, 2 September 2026, Venantius Limited, DublinPatent

Research Expertise

My research is multidisciplinary, spanning pharmacognosy, chemical/pharmacological sciences, and educational research. This breadth is reflected in my publications as Senior Author, including papers in Chemical Communications, European Journal of Medicinal Chemistry, Current Pharmaceutical Design, Current Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Scientific Reports, Journal of Natural Products, European Journal of Pharmacology, British Journal of Pharmacology, Angiogenesis, Pharmaceutical Research, and Pharmaceutics, as well as in Journal of Chemical Education and Pharmacy .

To date, funding for my research has been secured from Enterprise Ireland, Cancer Research Ireland, Research Ireland, the Irish Research Council for Science, Engineering and Technology, the Higher Education Authority, and the Department of Justice, Ireland. Support has also included funded PhD studentships from students" home institutions. As primary/sole supervisor, I have mentored and trained 19 PhD students to completion and a further student as secondary supervisor. In addition, I supervised five Pakistani-registered PhD students who completed substantial parts of their research during a six-month secondment to my laboratory.

For the next four years, my research is supported through funding secured from Research Ireland. Looking ahead, herbal medicinal plant production must increasingly shift from wild cultivation to plant biotechnological production, as climate change is already destabilizing both supply and quality. This is evident from my work with the European Pharmacopoeia, where specifications for certain plant-based medicines needed to be revised to ensure regulatory compliance.

In this regard, I am collaborating with the Luxembourg Institute of Science and Technology (LIST, https://www.list.lu/) and other EU partners on large-scale (300 L) biotechnological production of Irish medicinal and agriculturally important plants. We are in the final stages, with a 17 September deadline, of submitting a Horizon grant application titled "Forging solutions for agricultural applications through scalable plant cell factories." The requested total budget is €4 million, including €574,000 allocated to my work packages.

  • Title
    Studies on Novel Mast Cell Stabilising Compounds
    Summary
    The project involved in vitro and in vivo studies on novel mast cell stabilising compounds.
    Funding Agency
    Irish Research Council For Science Engineering and Technology
    Date From
    01-10-2008
    Date To
    30-09-2009
  • Title
    Endothelium as a Target in the Design of Novel Anti-cancer agents
    Summary
    The purpose of the funding was to design novel inhibitors of tumour- angiogenesis and vascularisation.
    Funding Agency
    Cancer Research Ireland
    Date From
    Oct. 2003
    Date To
    Sept. 2006
  • Title
    Synthesis and evaluation of tunable cyclolactams for antimalarial therapy
    Summary
    The project involved the synthesis of peptide-based tunable cyclolactams and their in vitro evaluation against Plasmodium falciparum. In collaboration with Dr Angus Bell, Department of Microbiology, TCD.
    Funding Agency
    Enterprise Ireland
    Date From
    Jan. 2004
    Date To
    Apr. 2005
  • Title
    Design of Tumour Homing Vasculature Targeting Agents
    Summary
    The project involved the synthesis of designed multiple ligands with homing properties to tumour vasculature.
    Funding Agency
    Irish Research Council for Science Engineering and Technology
    Date From
    01-10-2008
    Date To
    30-09-2011
  • Title
    Discovery of Novel Anti-cancer compounds
    Summary
    HE/98/249: Applied Research Grant
    Funding Agency
    Enterprise Ireland
    Date From
    Oct. 1998
    Date To
    Mar. 2001
  • Title
    Design of Hybrid-based Tumour Homing Anti-angiogenesis Agents
    Summary
    The purpose of this work was to design, synthesise and evaluate the homing properties of hybrid-based anti cancer compounds.
    Funding Agency
    Irish Research Council for Science Engineering and Technology
    Date From
    01-10-2008
    Date To
    30-09-2011
  • Title
    Pre-clinical Development of Novel Anti-allergic Compounds
    Summary
    Allergy Research: IF/2001/014: Research Innovation Fund.
    Funding Agency
    Enterprise Ireland
    Date From
    Dec 2001
    Date To
    Apr. 2004
  • Title
    Pre-clinical Development of Novel Anti-allergic Compounds
    Summary
    The work involved synthesis of lead compounds and evaluation of their effects in vitro and in vivo against passive cutaneous anaphylaxis.
    Funding Agency
    Enterprise Ireland
    Date From
    Oct 2004
    Date To
    Mar 2009
  • Title
    Appraisal of Wound Healing Potentials of Bergenia purpurascens in Photodynamic therapy (PDT): A Combined Chemical, In Vitro and In Vivo Approach
    Summary
    The proposal aims to evaluate the potential of the phytochemical constituents in Bergenia purpurascens in photodynamic wound healing healing.
    Funding Agency
    Research Ireland
    Date From
    01-03-2026
    Date To
    28-02-2030

Recognition

  • Commendation for being shortlisted for a Provost's Teaching Award 2013
  • Henkel Award (Organic Chemistry) 1988
  • Deans Award for Innovation in Teaching 2015
  • European Histamine Research Society date
  • Phytochemical Society of Europe date
  • The Society for Medicinal Plant Research date
  • Ireland representative on Committee 13b of the European Pharmacopoeia, Strasbourg. 2016
  • Ireland representative on Committee 13b of the European Pharmacopoeia, Strasbourg. 2016