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Professor Patrick Prendergast
Research Professor, Mechanical, Manuf & Biomedical Eng

Biography

Dr. Patrick Prendergast, BA, BAI, PhD, ScD, C.Eng, FIEI, FTCD, MRIA is Provost of Trinity College Dublin. Following his election on 2nd April 2011, he commenced his 10-year term as the 44th Provost of the College on 1st August 2011. Dr Prendergast held the Chair of Bio-engineering from 2007 to 2011. He is a Principal Investigator of the Trinity Centre for Bioengineering. Prior to working in TCD he held post-doctoral positions in Rizzoli Orthopaedic Institute, Bologna and the University of Nijmegen. On a sabbatical year (2001-2002) he was Visiting Professor, Institute of Fundamental Technological Research, Poland and Senior Research Fellow, Koiter Institute, Technical University of Delft, The Netherlands. He is a Chartered Engineer and a Fellow of the Institution of Engineers of Ireland. He is a past-president of the Section of Bioengineering of the Royal Academy of Medicine in Ireland (2000-2002), and a Past-President of the European Society of Biomechanics (2002-2004). He won the Parsons Medal in Engineering Science from the Royal Irish Academy in 2003. His research interests are in biomechanics and implant design, and in tissue engineering and mechanobiology. He was Dean of Graduate Studies at the University of Dublin from 2004-2007. In 2007 he was President of the European Alliance of Medical and Biological Engineering Societies. Also in 2007 he obtained a Chair in Bio-Engineering. In March 2008 he was elected to membership of the Royal Irish Academy. In July 2009 he was invited to deliver the Wartenweiler Memorial Lecture at the International Society of Biomechanics in Capetown, South Africa. He was Director of the Trinity Centre for Bioengineering from 2002 to 2008. He was Vice Provost/Chief Academic Officer from July 2008 to October 2010. He obtained a ScD from the University of Dublin in 2009.

Publications and Further Research Outputs

Peer-Reviewed Publications

Kelly, D.J. and O'Brien, F.J. and Prendergast, P.J., A Short History of Bioengineering Research in Ireland, Journal of Biomechanical Engineering, 140, (2), 2018, p021005 Journal Article, 2018 DOI

Xue, F. Lennon, A.B. McKayed, K.K. Campbell, V.A. Prendergast, P.J., Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells, Computer Methods in Biomechanics and Biomedical Engineering, 18, (5), 2015, p468 - 476 Journal Article, 2015 URL TARA - Full Text DOI

Taylor, M. Prendergast, P.J., Four decades of finite element analysis of orthopaedic devices: Where are we now and what are the opportunities?, Journal of Biomechanics, 48, (5), 2015, p767 - 778 Journal Article, 2015 TARA - Full Text DOI URL

Khayyeri H, Isaksson H, Prendergast PJ, Corroboration of computational models for mechanoregulated stem cell differentiation., Computer methods in biomechanics and biomedical engineering, 18, (1), 2015, p15-23 Journal Article, 2015 DOI TARA - Full Text

Rolfe,Rebecca A. , Nowlan,Niamh C. , Kenny,Elaine M. , Cormican,Paul , Morris,Derek W. , Prendergast, Patrick J. ., Kelly, Daniel John ., Murphy, P., Identification of mechanosensitive genes during skeletal development: Alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways, BMC Genomics, 15, (1), 2014, p48- Journal Article, 2014 TARA - Full Text DOI URL

Khayyeri H, Prendergast PJ, The emergence of mechanoregulated endochondral ossification in evolution., Journal of biomechanics, 46, (4), 2013, p731-7 Journal Article, 2013

Boyle CJ, Lennon AB, Prendergast PJ, Application of a mechanobiological simulation technique to stents used clinically., Journal of biomechanics, 46, (5), 2013, p918-24 Journal Article, 2013

Galibarov PE, Prendergast PJ, Lennon AB, A probabilistic modelling scheme for analysis of long-term failure of cemented femoral joint replacements., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 226, (12), 2012, p927-38 Journal Article, 2012

Nowlan, N.C., Dumas, G., Tajbakhsh, S., Prendergast, P.J., Murphy, P., Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis., Biomechanics and Modelling in Mechanobiology, 11, 2012, p207 - 219 Journal Article, 2012

Newe, C., Cunningham, E., Buchanan, F., Walker, G., Prendergast, P.J., Lennon, A., Dunne, N., Static and dynamic degradation of sintered calcium phosphate ceramics, Key Engineering Materials, 493-494, 2012, p861 - 865 Journal Article, 2012 DOI

Karen A. Roddy, Geraldine M. Kelly, Maarten H. van Esc, Paula Murphy, and Patrick J. Prendergast, Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint, Journal of Biomechanics, 44, (11), 2011, p143-149 Journal Article, 2011 TARA - Full Text

Boyle, C.J., Lennon, A.B., Prendergast P.J., In silico prediction of the mechanobiological response of arterial tissue: application to angioplasty and stenting, Journal of Biomechanical Engineering, 133, (8), 2011, p081001/1 - 081001/10 Journal Article, 2011 DOI TARA - Full Text

Byrne, D.P., Lacroix, D., Prendergast, P.J., Simulation of fracture healing in the tibia: Mechanoregulation of cell activity using a lattice modeling approach, Journal of Orthopaedic Research, 29, (10), 2011, p1496 - 1503 Journal Article, 2011 URL DOI

De Santis, G., Lennon, A.B., Boschetti, F., Verhegghe, B., Verdonck, P., Prendergast, P.J., How can cells sense the elasticity of a substrate? An analysis using a cell tensegrity model, European Cells and Materials, 22, 2011, p202 - 213 Journal Article, 2011

Checa, S. , Prendergast, P.J., Duda, G.N, Inter-species investigation of the mechano-regulation of bone healing: Comparison of secondary bone healing in sheep and rat, Journal of Biomechanics , 44, (7), 2011, p1237-1245 Journal Article, 2011 DOI

Nowlan, N.C., Dumas, G., Tajbakhsh, S., Prendergast, P.J., Murphy, P. , Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis , Biomechanics and Modeling in Mechanobiology, 11, (1-2), 2011, p207-219 Journal Article, 2011 TARA - Full Text

Kelly, G.M., Kilpatrick, J.I., van Es, M.H., Weafer, P.P., Prendergast, P.J., Jarvis, S.P. , Bone cell elasticity and morphology changes during the cell cycle , Journal of Biomechanics , 44, (8), 2011, p1484-1490 Journal Article, 2011 DOI

Nowlan N.C., Dumas, G., Tajbakhsh S., Prendergast P. And Murphy P. , Passive Movement Due to External Mechanical Stimulation Plays a Role in Embryonic Skeletal Development. , Biomechanics and Modeling in Mechanobiology , epub ahead of print, 2011 Journal Article, 2011

Khayyeri, H., Checa, S., Tägil, M., Aspenberg, P., Prendergast, P.J, Variability observed in mechano-regulated in vivo tissue differentiation can be explained by variation in cell mechano-sensitivity, Journal of Biomechanics , 44, (6), 2011, p1051-1058 Journal Article, 2011 DOI

Checa S, Prendergast PJ, Duda GN, Inter-species investigation of the mechano-regulation of bone healing: comparison of secondary bone healing in sheep and rat., Journal of biomechanics, 44, (7), 2011, p1237-45 Journal Article, 2011

P.J. Prendergast, P.E. Galibarov, C. Lowrey, A.B. Lennon, Computer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesis, Journal of the Mechanical Behavior of Biomedical Materials, 4, (8), 2011, p1880-1887 Journal Article, 2011 TARA - Full Text

Roddy KA, Prendergast PJ, Murphy P, Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos., PloS one, 6, (2), 2011, pe17526 Journal Article, 2011 DOI TARA - Full Text

Biomechanical modelling of cells in mechanoregulation in, editor(s)Gefen, A. , Cellular and Biomolecular Mechanics and Mechanobiology, Berlin, Springer, 2011, pp297 - 329, [Lennon, A.B., Khayyeri, H., Xue, F., Prendergast, P.J.] Book Chapter, 2011

Computational techniques for selection of biomaterial scaffolds for tissue engineering in, editor(s)P.R. Fernandes, P. Bártolo , Advances on Modelling in Tissue Engineering , Berlin, Springer, 2011, [Checa, S, Sandino, C, Byrne DP, Kelly, DJ, Lacroix, D & Prendergast, PJ] Book Chapter, 2011

Khayyeri, H, Checa, S, Tagil, M, O'Brien, FJ, Prendergast, PJ, Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness, Journal of Materials Science: Materials in Medicine, 21, (8), 2010, p2331-2336 Journal Article, 2010 DOI

Kearney EM, Farrell E, Prendergast PJ, Campbell VA, Tensile strain as a regulator of mesenchymal stem cell osteogenesis., Annals of Biomedical Engineering, 38, (5), 2010, p1767-1779 Journal Article, 2010 DOI

Niamh C. Nowlan, Céline Bourdon, Shahragim Tajbakhsh, Gérard Dumas, Patrick J. Prendergast and Paula Murphy, Developing bones are differentially affected by compromised skeletal muscle formation, Bone, 46, 2010, p1275-1285 Journal Article, 2010 DOI TARA - Full Text

Predictive modelling in mechanobiology: combining algorithms for cell activities in response to physical stimuli using a lattice-modelling approach in, editor(s)M Kuczma, K Wilmanski , Computer Methods in Mechanics, Berlin Heidelberg, Springer-Verlag, 2010, pp423 - 435, [Checa, S, Prendergast, PJ] Book Chapter, 2010

Flannery, O.M., Britton, J.R., O'Reilly, P., Mahony, N., Prendergast, P.J., Kenny, P.J, The threshold force required for femoral impaction grafting in revision hip surgery: A preliminary study in sow femurs, Acta Orthopaedica, 81, (3), 2010, p303-307 Journal Article, 2010 URL DOI

Nowlan, N. C., Sharpe, J., Prendergast P.J. and Murphy P. , Mechanobiology of Embryonic Skeletal Development: Insights from Animal Models., Birth Defects Research Part C: Embryo Today, 90, (3), 2010, p203-213 Journal Article, 2010 DOI

Galibarov, P.E., Prendergast, P.J., Lennon, A.B., A method to reconstruct patient-specific proximal femur surface models from planar pre-operative radiographs, Medical Engineering and Physics, 32, (101), 2010, p1180-1188 Journal Article, 2010 DOI

Checa, S, Prendergast, PJ, Effect of cell seeding and mechanical loading on vascularization and tissue formation inside a scaffold: a mechanobiological model using a lattice approach to simulate cell activity, Journal of Biomechanics, 43, (5), 2010, p961-968 Journal Article, 2010

Mulvihill, BM, Prendergast, PJ, Mechanobiological regulation of the remodelling cycle in trabecular bone and possible pathways for osteoporosis, Clinical Biomechanics, 25, 2010, p491 - 498 Journal Article, 2010

Sandino, C, Checa, S, Prendergast, PJ, Lacroix, D, Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach, Biomaterials, 31, (8), 2010, p2446 - 2452 Journal Article, 2010 TARA - Full Text

Computational models of tissue differentiation in, editor(s)S. De, F. Guilak, M. Mofrad , Computational Methods in Biomechanics, New York, Springer, 2010, pp353 - 372, [Prendergast, PJ, Checa, S, Lacroix, D] Book Chapter, 2010 DOI

Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents., Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, (1921), 2010, p2919-35 Journal Article, 2010 TARA - Full Text DOI URL

Nowlan, N.C. , Prendergast, P.J. , Tajbakhsh, S., Murphy, P., Identifying candidate mechanoregulators of skeletal development, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, 11th ASME Summer Bioengineering Conference, SBC2009, Lake Tahoe, 17-21 June, PART A,, 2009, pp149-150 Conference Paper, 2009

Prendergast PJ, Lally C, Lennon AB, Finite element modelling of medical devices., Medical engineering & physics, 31, (4), 2009, p419 Journal Article, 2009

Khayyeri, H, Checa, S, Tagil, M, Prendergast, PJ, Corroboration of mechanobiological simulations of tissue differentiation in an in vivo bone chamber using a lattice-modelling approach, Journal of Orthopaedic Research, 27, (12), 2009, p1659 - 1666 Journal Article, 2009 DOI

Boyle, C.J., Lally, C., Prendergast, P.J, Injury driven biological model of restenotic lesion development predicts the effects of stent geometry on restenosis, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, 11th ASME Summer Bioengineering Conference, SBC2009, Lake Tahoe, edited by 17-21 June , PART B, ASME, 2009, pp1055-1056 Conference Paper, 2009

Lacroix, D, Plannel, JA, Prendergast PJ, Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering , Philosophical Transactions of the Royal Society A: Mathematical, Engineering and Physical Sciences , 367, 2009, p1993 - 2009 Journal Article, 2009 DOI

Karen A. Roddy, Niamh C Nowlan, Patrick J. Prendergast, and Paula Murphy, 3D representation of the developing chick knee joint: a novel approach integrating multiple components, Journal of Anatomy, 214, (3), 2009, p374 - 387 Journal Article, 2009 DOI URL

Scannell PT, Prendergast PJ, Cortical and interfacial bone changes around a non-cemented hip implant: simulations using a combined strain/damage remodelling algorithm, Medical Engineering and Physics, 31, 2009, p477 - 488 Journal Article, 2009 DOI

Michael Early; Catriona Lally; Patrick J. Prendergast; Daniel J. Kelly, Stresses in peripheral arteries following stent placement: a finite element analysis, Computer Methods in Biomechanics and Biomedical Engineering, 12, (1), 2009, p25 - 33 Journal Article, 2009 URL TARA - Full Text DOI

Medical Engineering & Physics: Special Issue on Finite Element Modelling of Medical Devices, 31, (2009), 419 - 494p, Prendergast, PJ, Lally, C, Lennon, AB, [eds.] Journal, 2009 DOI

Checa, S, Prendergast, PJ, A mechanobiological model for tissue differentiation that includes angiogenesis: a lattice-based modeling approach, Annals of Biomechanical Engineering, 37, 2009, p129 - 145 Journal Article, 2009 DOI

De Santis, G., Boschetti, F., Lennon, A.B., Prendergast, P.J., Verdonck, P., Verhegghe, B, How an eukaryotic cell senses the substrate stiffness? An exploration using a finite element model with cytoskeleton modelled as tensegrity structure, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009 , ASME Summer Bioengineering Conference 2009, SBC2009 , Lake Tahoe, CA, 17-21 June, PART A, 2009, pp559-560 Conference Paper, 2009

Prendergast, P.J., Lally, C., Lennon, A.B., Finite element modelling of medical devices , Medical Engineering and Physics, 31, (4), 2009, 419 Journal Article, 2009 DOI

Andreykiv, A, van Keulen, F, Prendergast, PJ, Computational mechanobiology to study the effect of surface geometry on peri-implant tissue differentiation, Journal of Biomechanical Engineering, 130, 2008, p051015.1 - 051015.11 Journal Article, 2008

Nowlan N, Murphy P, Prendergast PJ, Dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones, Journal of Biomechanics, 41, (3), 2008, p249 - 258 Journal Article, 2008 DOI URL TARA - Full Text

McMahon, L.A. , Prendergast, P.J. , Campbell, V.A., A comparison of the involvement of p38, ERK1/2 and PI3K in growth factor-induced chondrogenic differentiation of mesenchymal stem cells, Biochemical and Biophysical Research Communications , 368, (4), 2008, p990 - 995 Journal Article, 2008 DOI URL

Galibarov, P, Lennon, A.B., and Prendergast, P.J., Retrospective evaluation of an automated method for generating patient-specific FE femur models, 16th Congress of European Society of Biomechanics, Conference, Lucerne, Switzerland, 6-9 July, 2008 Conference Paper, 2008

J.G. McGarry, P. Maguire, P.J. Prendergast, V.A. Campbell, B.C. O'Connell and S.P. Jarvis, Stimulating Nitric Oxide response in single osteoblasts using atomic force microscopy', Journal of Orthopaedic Research, 26, (4), 2008, p513-520 Journal Article, 2008 DOI URL

MacNiocaill RF, Guerin S, Britton JR, Lennon AB, Prendergast PJ, Kenny PJ, Experimental investigation of negative pressure intrusion techniques of acetabular cementation in total hip arthroplasty, Acta Orthopaedica Belgica, 74, (1), 2008, p64 - 71 Journal Article, 2008 URL URL

Simms CK & Prendergast PJ (eds.), Perspectives in Design and Bioengineering, Essays in honour of CG Lyons, Trinity College Dublin, Dublin, Trinity Centre for Bioengineering, 2008 Book, 2008

Vard, J.P., Kelly, D.J., Blayney, A.W. and Prendergast, P.J. , The influence of ventilation tube design on the magnitude of stress imposed at the implant/tympanic membrane interface, Medical Engineering and Physics, 30, (2), 2008, p154-163 Journal Article, 2008 TARA - Full Text URL DOI

McMahon, L.A., Reid, A.J., Campbell, V.A. & Prendergast, P.J. , Regulatory Effects of Mechanical Strain on the Chondrogenic Differentiation of MSCs in a Collagen-GAG Scaffold: Experimental and Computational Analysis , Annals of Biomedical Engineering, 36, (2), 2008, p185-194 Journal Article, 2008 DOI URL

Prendergast, PJ, Brown, SH, Britton, JR, Research programmes that promote novel, ambitious, unconventional, and high risk research: an analysis, Industry and Higher Education, 22, (4), 2008, p215 - 221 Journal Article, 2008

Galibarov, P, Lennon, A.B., and Prendergast, P.J. , Quantitative assessment of a technique for patient-specific geometry from planar radiographs., 4th European Congress For Medical and Biomedical Engineering 2008, "Engineering for Health", FCCC Antwerp, 23-27 November, International Federation for Medical and Biomedical Engineering, 2008 Conference Paper, 2008

McMahon, L.A., Campbell, V.A., Prendergast, P.J., Involvement of stretch-activated ion channels in strain-regulated glycosaminoglycan synthesis in mesenchymal stem cell-seeded 3D scaffolds , Journal of Biomechanics, 41, (9), 2008, p2055-2059 Journal Article, 2008 DOI

Nowlan, N., Prendergast P.J. and Murphy, P., Identification of Mechanosensitive Genes during Embryonic Bone Formation. , PLoS Computational Biology, 4, (12), 2008, pe1000250- Journal Article, 2008 TARA - Full Text

McMahon LA, O'Brien FJ, Prendergast PJ, Biomechanics and mechanobiology in osteochondral tissues, Regenerative Medicine, 3, 2008, p743 - 759 Journal Article, 2008 DOI

Boccaccio A, Prendergast PJ, Pappalettere C, Kelly DJ, Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period, Medical and Biological Engineering and Computing, 46, (3), 2008, p283 - 298 Journal Article, 2008 DOI TARA - Full Text URL

Kearney EM, Farrell E, Prendergast PJ, Campbell VA, Mechanobiology of a tensile strain-induced osteogenic response in mesenchymal stem cells, Annals of Biomedical Engineering, 2008 Journal Article, 2008

Byrne, D. P., Lacroix, D., Kelly, D. J., Prendergast, P. J., Modelling cell dispersal in the fracture callus., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Kearney EM, Prendergast PJ, Campbell VA, Mechanisms of strain-mediated mesenchymal stem cell apoptosis, Journal of Biomechanical Engineering, 130, 2008 Journal Article, 2008 DOI

Lennon, A.B. and Prendergast, P.J. , Assessing the influence of bone remodelling on revision risk of cemented hip prostheses: a patient-specific retrospective study, Proceedings of 17th EORS Meeting, 17th EORS Meeting, Madrid, Spain, 91B, (Suppl), 2008, pp71 Conference Paper, 2008 URL

McGarry, JG, Maguire, P, Prendergast, PJ, Campbell, VA, O'Connell, BC, Jarvis, SP, Stimulation of nitric oxide mechanotransduction in single osteoblasts using atomic force microscopy, Journal of Orthopaedic Research, 26, (4), 2008, p513 - 521 Journal Article, 2008 DOI URL

Mulvihill, BM, Prendergast PJ, An algorithm for bone mechanoresponsiveness: implementation to study the effect of patient-specific cell mechanosensitivity on trabecular bone loss, Computer Methods in Biomechanics and Biomedical Engineering, 11, 2008, p443 - 451 Journal Article, 2008 DOI

Foolen J., van Donkelaar C., Nowlan N., Murphy P., Huiskes R. and Ito K., Collagen orientation in periosteum and perichondrium is aligned with preferential directions of tissue growth., Journal of Orthopaedic Research, 26, (9), 2008, p1263 - 1268 Journal Article, 2008 DOI URL

Kearney M, Prendergast PJ, Campbell VA, Mechanisms of strain-mediated mesenchymal stem cell apoptosis, Journal of Biomechanical Engineering, 130, (6), 2008, pArticle number 061004 Journal Article, 2008 DOI

McMahon LA, Reid AJ, Campbell VA, Prendergast PJ, Regulatory effects of mechanical strain on the chondrogenic differentiation of MSCs in a collagen-GAG scaffold: experimental and computational analysis., Annals of biomedical engineering, 36, (2), 2008, p185-94 Journal Article, 2008

Stops AJF, McMahon LA, O'Mahoney D, Prendergast PJ, McHugh PE, A finite element prediction of the strain on cells in a highly porous collagen glycosaminoglycan scaffold, Journal of Biomechanical Engineering, 130, 2008, p061001.1 - 061001.11 Journal Article, 2008

Lennon, A.B., Mac Niocaill, R.F., Kenny, P.J., Prendergast, P.J. , Assessing the influence of age-dependent bone stiffness on aseptic loosening of cemented total hip stems: an in silico study, Transactions of the Orthopaedic Research Society, San Francisco, USA, 3-5 March, 2008 Conference Paper, 2008

Prendergast PJ, "May the force be with you": 14th Samuel Haughton Lecture, Irish Journal of Medical Science, 177, 2008, p289 - 292 Journal Article, 2008 DOI

McMahon LA, Campbell VA, Prendergast PJ, Involvement of stretch-activated ion channes in strain-regulated glycosaminoglycan synthesis in mesenchymal stem cell-seeded 3D scaffolds, Journal of Biomechanics, 41, 2008, p2055 - 2059 Journal Article, 2008 DOI URL

Mulvihill BM, McNamara LM, Prendergast PJ., Loss of trabeculae by mechano-biological means may explain rapid bone loss in osteoporosis., Journal of the Royal Society - Interface, 5, 2008, p1243 - 1253 Journal Article, 2008 URL TARA - Full Text DOI

Lennon, A.B. and Prendergast, P.J. , The cement-bone interface: is it susceptible to damage adaptive remodeling?, IFMBE Proceedings, 4th European Congress For Medical and Biomedical Engineering, Antwerp, Belgium, 23-27 November 2008, edited by Vander Sloten, J, Verdonck, P., Nyssen, M., Haueisen, J. , 22, Springer-Verlag, 2008, pp1990 - 1993 Conference Paper, 2008 DOI

Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , Dublin, 2008, 28 p Proceedings of a Conference, 2008

Kanichai M, Ferguson D, Prendergast PJ, Campbell VA, Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: A role for AKT and hypoxia-inducible factor (HIF)-1, Journal of Cellular Physiology, 216, (3), 2008, p708 - 715 Journal Article, 2008 DOI

Andreykiv A, van Keulen F, Prendergast PJ, Computational mechanobiology to study the effect of surface geometry on peri-implant tissue differentiation., Journal of biomechanical engineering, 130, (5), 2008, p051015 Journal Article, 2008

Andreykiev, A, van Keulen, F, Prendergast, PJ, Simulation of fracture healing incorporating mechanoregulation of tissue differentiation and dispersal / proliferation on cell populations, Biomechanics and Modelling in Mechanobiology, 7, 2008, p443 - 461 Journal Article, 2008

Byrne, E.M., Farrell, E., McMahon, L.A., Haugh, M.G., O'Brien, F.J., Campbell, V.A., Prendergast, P.J., O'Connell, B.C., Gene expression by marrow stromal cells in a porous collagen- glycosaminoglycan scaffold is affected by pore size and mechanical stimulation , Journal of Materials Science: Materials in Medicine, 19, (11-12), 2008, p3455-3463 Journal Article, 2008 DOI

Keeling, P, Prendergast, P.J., Lennon, A.B., Kenny, P.J., Cement-in-cement revision hip arthroplasty: an analysis of clinical and biomechanical literature, Archives of Orthopaedic Trauma Surgery, 128, (10), 2008, p1193 - 1199 Journal Article, 2008 DOI

D.J. Kelly, A. Crawford, S.C. Dickinson, T.J. Sims, A.P. Hollander, P.J. Prendergast and P.V. Hatton, Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage, Journal of Materials Science: Materials in Medicine, 18, (2), 2007, p273-281 Journal Article, 2007 URL DOI TARA - Full Text

Byrne, D.P., Lacroix, D., Kelly, D.J., Prendergast, P.J., Finite element modeling of dissolution of a regular structured scaffold for tissue engineering, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp134-135 Conference Paper, 2007

Byrne, DP, Lacroix, D, Kelly, DJ, Plannel, J, Prendergast, PJ, Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus, and dissolution rate of a scaffold: application of mechanobiological models in tissue engineering, Biomaterials, 28, (36), 2007, p5544 - 5554 Journal Article, 2007 URL DOI

Jeffers, JRT, Browne, M, Lennon, AB, Prendergast, PJ, Taylor, M, Cement mantle fatigue failure in total hip replacement: experimental and computational testing, Journal of Biomechanics, 40, (7), 2007, p1525 - 1533 Journal Article, 2007 URL DOI

A.J.F. Stops, L.A. McMahon, D. O'Mahoney, P.E. McHugh and P.J. Prendergast, A finite element prediction of cellular strain in a GAG-scaffold', 2007 Summer Bioengineering Conference, Colorado, American Society of Mechanical Engineers, 2007 Conference Paper, 2007

McNamara LM, Prendergast PJ, Bone remodelling algorithms incorporating both strain and microdamage stimuli , Journal of Biomechanics, 40, (6), 2007, p1381 - 1391 Journal Article, 2007 DOI URL

Galibarov, P.E., Lennon, A.B., Prendergast, P.J., Automated generation of 3D bone model from planar X-ray image for patient-specific finite element modelling, Proceedings of the International Symposium CompIMAGE 2006 , Computational Modelling of Objects Represented in Images. Fundamentals, Methods and Applications, Coimbra, Portugal , 20-21 October 2006 , edited by J. M. R.S. Tavares and R.M. Natal Jorge , Taylor and Francis Group, London , 2007, pp191 - 195 Conference Paper, 2007

Galibarov, P.E., Lennon, A.B., Prendergast, P.J. , Patient-specific finite element models based on radiographs for pre-operative planning , Proceedings of the 2007 Summer Workshop of the European Society of Biomechanics, Finite Element Modelling in Biomechanics and Mechanobiology , Trinity College Dublin, 26-28 August 2007, edited by Lennon, A.B., Prendergast, P.J. , Trinity Centre for Bioengineering, Trinity College Dublin, Ireland, 2007, pp201 - 202 Conference Paper, 2007

Marenzana, M, Kelly, DJ, Prendergast, PJ, Brown, RA, A collagen-based interface construct for the assessment of cell-dependent mechanical integration of tissue surfaces, Cell and Tissue Research, 327, (2), 2007, p293 - 300 Journal Article, 2007 DOI URL

Prendergast, PJ, Pérez, MA, Random-walk models of cell dispersal included in mechano-biological simulations of tissue differentiation, Journal of Biomechanics, 40, (10), 2007, p2244 - 2253 Journal Article, 2007 URL DOI

De Santis, G., McGarry, J.G., Lennon, A.B., Prendergast, P.J. , Finite element models of AFM indentation of adherent cell , Proceedings of the 2007 Summer Workshop of the European Society of Biomechanics, Finite Element Modelling in Biomechanics and Mechanobiology , Trinity College Dublin, 26-28 August 2007, edited by Lennon, A.B., Prendergas, P.J. , Trinity Centre for Bioengineering, Trinity College Dublin, Ireland, 2007, pp187 - 188 Conference Paper, 2007

Farrell, E, Byrne, EM, Fischer, J, O'Brien, FJ, O'Connell, BC, Prendergast, PJ, Campbell, VA, A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds., Technology and Healthcare, 15, (1), 2007, p19 - 31 Journal Article, 2007 TARA - Full Text URL

Nowlan, NC, Murphy, P, Prendergast, PJ, Mechanobiology of embryonic limb development, Annals of the New York Academy of Sciences, 1101, 2007, p389 - 411 Journal Article, 2007 URL DOI TARA - Full Text

P.J. Prendergast and A.B. Lennon, An introduction to the workshop on finite element modelling in biomechanics and mechanobiology, Finite Element Modelling in Biomechanics and Mechanobiology European Society of Biomechanics, Dublin, Ireland , 2007, pp1-4 Conference Paper, 2007 URL

Maguire P, Kilpatrick JI, Kelly G, Prendergast PJ, Campbell VA, O'Connell BC, Jarvis SP, Direct mechanical measurement of geodesic structures in rat meseenchymal stem cells, Human Frontiers Science Program Journal, 1, (3), 2007, p181 - 191 Journal Article, 2007 DOI URL

N. Nowlan, P. Murphy and P.J. Prendergast, Mechanical stimuli resulting from embryonic muscle contractions promote avian periosteal bone collar formation', Summer Bioengineering Conference,, Colorado , American Society of Mechanical Engineers, 2007 Conference Paper, 2007

A.B. Lennon, P.J. Prendergast(ed.), Finite Element Modelling in Biomechanics and Mechanobiology , Proceedings of the 2007 Summer Workshop of the European Society of Biomechancis , 26-28 August 2007, Trinity Centre for Bioengineering: Dublin ISBN-10: 0-9549593-1-X , 2007, 213 + xiv p Proceedings of a Conference, 2007

European Society of Biomechanics, Lennon AB, Prendergast PJ (Eds.) , Finite Element Modelling in Biomechanics and Mechanobiology,, Dublin, Trinity College Dublin, European Society of Biomechanics, 2007, i-xiv + 1-212pp Book, 2007

O'Brien, F.J.; Harley, B.A.; Waller, M.A.; Yannas, I.V; Gibson, L.J and Prendergast, P.J., The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering., Technology and Healthcare , 15, (1), 2007, p3 - 17 Journal Article, 2007 TARA - Full Text URL

Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 75 p Proceedings of a Conference, 2007

B.M. Mulvihill, L.M. McNamara and P.J. Prendergast, The effect of patient-specific bone remodelling rates on remodelling/repair in trabecular bone, Proceedings of the 3rd International Conference on Computational Bioengineering, 3rd International Conference on Computational Bioengineering, Universidad Central de Venezuela, Caracas, edited by M. Cerrolaza , 2007, pp237-242 Conference Paper, 2007

Lennon, A.B., Britton, J.R., Mac Niocaill, R.F., Byrne, D.P., Kenny, P.J., Prendergast, P.J., Predicting revision risk for aseptic loosening of femoral components in total hip arthroplasty in individual patients - a finite element study, Journal of Orthopaedic Research, 25, (6), 2007, p779-788 Journal Article, 2007 URL DOI

Prendergast, P.J. , Computational modelling of cell and tissue mechanoresponsiveness', Gravitational and Space Biology, 20, (2), 2007, p43-49 Journal Article, 2007 URL

P. Maguire, J.I. Kilpatrick, G. Kelly, P.J. Prendergast, V.A. Campbell, B.C. O'Connell and S.P. Jarvis, Direct mechanical measurement of geodesic structures in rat mesenchymal stem cells', Human Frontiers Science Program Journal, 1, (3), 2007, 181-191 Journal Article, 2007 URL DOI

D.P. Byrne, D. Lacroix, D.J. Kelly and P.J. Prendergast, The effect of loading on bone regeneration in a regular structured scaffold, Proceedings of the 3rd International Conference on Computational Bioengineering, 3rd International Conference on Computational Bioengineering, Universidad Central de Venezuela, Caracas , edited by M. Cerrolaza , 2007, pp215-220 Conference Paper, 2007

Lennon, A.B. , Sources of nonlinearities in biomechanical models, Proceedings of the European Society of Biomechanics Workshop, Finite Element Modelling in Biomechanics and Mechanobiology, Trinity Centre for Bioengineering, Trinity College Dublin, Ireland, 26-28 August , edited by A.B. Lennon and P.J. Prendergast , 2007, pp10-15 Conference Paper, 2007

O'Brien, FJ, Waller, MA, Harley, BA, Yannas, IV, Gibson, LJ, Prendergast, PJ, The effect of pore size on permeability and cell attachment in collagen scaffolds for tissue engineering, Technology and Healthcare, 15, (1), 2007, p3 - 17 Journal Article, 2007 URL

Automated generation of 3D bone models from planar X-ray images for patient-specific finite element modeling applications in, editor(s)JMRS Tavares, RM Natal Jorge , Computational Modelling of Objects Represented in Images, London, Taylor & Francis Group, 2007, pp191 - 195, [Galibarov, PE, Lennon, AB, Prendergast, PJ] Book Chapter, 2007

Combining mechanoregulation algorithms for bone remodeling and tissue differentiation in, editor(s)Gonzalez Y , Bioengineering Modelling and Computer Simulations, Madrid, CIMNE Editorial, 2007, pp238 - 248, [Prendergast PJ] Book Chapter, 2007

Combining mechanoregulation algorithms for bone remodelling and tissue differentiation in, editor(s)Y González, M Cerrolaza , Bioengineering Modelling and Computer Simulation, Barcelona, 2007, pp238 - 248, [Prendergast, PJ] Book Chapter, 2007

Lennon, AB, Britton, JR, MacNiochaill, R, Byrne, D, Prendergast, PJ, Predicting revision risk for aseptic loosening of femoral components in total hip arthroplasty in individual patients - a finite element study, Journal of Orphopaedic Research, 25, (6), 2007, p779 - 788 Journal Article, 2007 URL DOI

Prendergast PJ, Computational modelling of cell and tissue mechanoresponsiveness, Gravitational and Space Biology, 20, (2), 2007, p43 - 49 Journal Article, 2007 URL

P.J. Prendergast, Combining mechanoregulation algorithms for bone remodelling and tissue differentiation, International Center for Numerical Methods in Engineering, Barcelona, edited by Y. González and M. Cerrolaza , 2007, pp238-248 Conference Paper, 2007 URL

Lennon, A.B, Britton, J.R., MacNicoill, R.F., Kenny, P.J., Prendergast, P.J , Can patient-specific finite element simulation be used for pre-operative assessment of early revision risk? , Engineers and Surgeons: Joined at the Hip: Refining future strategies in total hip replacement, One Great Georges St., London, U.K., 19-21 April 2007, Institution of Mechanical Engineers , 2007, pp21 - 24 Conference Paper, 2007

Stents in, editor(s)Akay M , Wiley Encyclopaedia of Biomedical Engineering, John Wiley & Sons, 2007, pp3345 - 3355, [Lally C, Prendergast PJ, Kelly D] Book Chapter, 2007 URL

Pérez, M.A. and Prendergast, P.J. , Random-walk models of cell dispersal included in mechano-biological simulations of tissue differentiation', Journal of Biomechanics, 40, (10), 2007, p2244 - 2253 Journal Article, 2007 URL DOI

B.M. Mulvihill, L.M. McNamara and P.J. Prendergast, Increases in elastic modulus of trabecular bone tissue leads to more rapid perforation of trabecular osteoporotic bone' , 2007 Summer Bioengineering Conference, Colorado , American Society of Mechanical Engineers, 2007 Conference Paper, 2007

Lennon, A.B., Britton, J.R., MacNiocaill, R.F., Kenny, P.J., Prendergast, P.J., Is high accuracy anatomical modelling necessary for computer simulation of implant loosening in total hip replacement?, Journal of Biomechanics,, 5th World Congress of Biomechanics incorporating 15th Congress of the European Society of Biomechanics, Munich, Germany, 29th July - 4th Aug, 39, (1), 2006, ppS425 Conference Paper, 2006

Byrne, D.P., Prendergast, P.J., Kelly, D.J., Optimisation of scaffold porosity using a stochastic model for cell proliferation and migration in mechanobiological simulations, Journal of Biomechanics , Proceedings of the V World Congress of Biomechanics, Munich, Germany., 39, (1), 2006, ppS413 Conference Paper, 2006

McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 106 p Proceedings of a Conference, 2006

Prina-Mello A, Farrell E, Prendergast PJ, Campbell V, Coey JMD, Influence of Strong Static Magnetic, Bioelectromagnetics, 27, (1), 2006, p35 - 42 Journal Article, 2006 URL

Nowlan, N.C. , Murphy P. and Prendergast, P.J. , The influence of mechanical forces in the growing embryonic limb, Proceedings of the 52 nd Annual Meeting of the Orthopaedic Research Society , 52 nd Annual Meeting of the Orthopaedic Research Society , Orthopaedic Research Society , 2006, pp31 Conference Paper, 2006

Prendergast P.J., Britton J.R., Scannell P.T., Lennon A.B. , Failure of biomaterials in implant fixation , Proceedings of the 16th European Conference on Fracture , Fracture of Nano and Engineering Materials and Structures , Greece , 2006, edited by E.E. Gdoutos , Springer, Berlin, ISBN 978-1-4020-4971-2 , 2006, pp1031 - 1032 Conference Paper, 2006 DOI

Nowlan, N.C. , Murphy P. and Prendergast, P.J., The characterisation of mechanical stresses in the growing avian embryonic limb, Proceedings of the 5th World Congress of Biomechanics, 5th World Congress of Biomechanics, 2006 Conference Paper, 2006

McNamara LM, Van der Linden JC, Weinans H, Prendergast PJ, Stress-concentrating effect of resorption lacunae in trabecular bone, Journal of Biomechanics, 39, (4), 2006, p734 - 741 Journal Article, 2006 URL DOI

Lennon A, Britton J, MacNiocaill R, Byrne D, Kenny P, Prendergast PJ, Predicting revision risk in a group of total hip replacement patients using finite element analysis, Proceedings of the American Society of Mechanical Engineers Summer Bioengineering Meeting, Summer Bioengineering Meeting, 52, American Society of Mechanical Engineers, 2006 Conference Paper, 2006

Prosthesis fixation for orthopaedics in, editor(s)Webster, JE , Wiley Encyclopaedia of Medical Devices and Instrumentation, New Jersey, John Wiley & Sons, 2006, pp192 - 198, [Prendergast, PJ] Book Chapter, 2006

Nowlan, N.C., Murphy P. and Prendergast, P.J., The calculation of mechanical stresses in the growing avian embryonic limb using optical projection tomography, Proceedings of the 2006 Summer Bioengineering Conference of the American Society of Mechanical Engineering, Summer Bioengineering Conference of the American Society of Mechanical Engineering, 2006 Conference Paper, 2006

McNamara, LM, Ederveen, AGH, Lyons, CG, Weinans, H, Price C, Schaffler, MB, Prendergast, PJ, Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing, Bone, 39, (2), 2006, p392 - 400 Journal Article, 2006 DOI URL

McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 82 p Proceedings of a Conference, 2006

McNamara LM, van der Linden J, Weinans H, Prendergast PJ, Stress-concentrating effect of resorption lacunae in trabecular bone, Journal of Biomechanics, 39, (4), 2006, p734 - 741 Journal Article, 2006 DOI URL

Prendergast, PJ, Lee, TC, Walking on water: The biomechanics of Professor MA MacConaill (1921-1987), Journal of the Irish Colleges of Physicians and Surgeons, 175, 2006, p69 - 73 Journal Article, 2006

Prina-Mello A., Farrell E., Prendergast P.J., Campbell V., Coey J.M.D. , Influence of Strong Static Magnetic Fields on Primary Cortical Neurons, Bioelectromagnetics, 27, (1), 2006, p35 - 42 Journal Article, 2006 DOI URL

E. Farrell., F.J. O'Brien., P. Doyle., J. Fischer., I. Yannas., B. O'Connell., P.J. Prendergast & V.A. Campbell , A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes., Tissue Engineering, 12, (3), 2006, p459 - 468 Journal Article, 2006 URL DOI

Prendergast, P.J., Kelly, D.J., McMahon, L.A., Campbell, V.A. , A computational optimization of scaffolds for tissue engineering of cartilage., Tissue Engineering, Abstracts of 8th TESI Annual Meeting 2005, Shanghai, China, October 22-25, 12, 2006, pp1024 Meeting Abstract, 2006

Kelly DJ, Prendergast PJ, Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair, Tissue Engineering, 12, (9), 2006, p2509 - 2519 Journal Article, 2006 TARA - Full Text URL DOI

Prina-Mello A, Farrell E, Prendergast PJ, Campbell V, Coey JMD , Influence of strong static magnetic fields on primary cortical neurons , Bioelectromechanics, 27, 1, (Jan), 2006, p35 - 42 Journal Article, 2006

European Journal of Morphology, 42, (2005), 1 - 2p, Lee, TC, Prendergast, PJ , [Guest Eds.], Editorial: Microdamage in Bone Journal, 2005

Nowlan NC, Prendergast PJ., Evolution of mechanoregulation of bone growth will lead to non-optimal bone phenotypes, Journal of Theoretical Biology, 235, (3), 2005, p408-18 Journal Article, 2005 URL DOI TARA - Full Text

McGarry, JG, Klein-Nulend, J, Mullender, MG, Prendergast, PJ, A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study, The FASEB Journal, 19, 2005, p482 - 484 Journal Article, 2005 DOI TARA - Full Text

Britton, JR, Prendergast, PJ, Preclinical testing of femoral hip components: an experimental investigation with four prostheses, Journal of Biomechanical Engineering, 127, 2005, p872 - 880 Journal Article, 2005 URL DOI

Hardiman DA, O'Brien FJ, Prendergast PJ, Croke DT, Staines A, Lee TC, Tracking the changes in uploaded bone: Morphology and gene expression, European Journal of Morphology, 42, (4-5), 2005, p208 - 216 Journal Article, 2005 URL DOI

Prendergast, P.J., Kelly, D.J., Perez, M.A., Computational models for the study of the mechanobiology of bone regeneration, European Society of Biomechanics Thematic Workshop: Mechanobiology of Cells and Tissue Regeneration, Leuven, Aug 2005, 2005, pp29-30 Conference Paper, 2005

Prina_Mello, A, Farrell, E, Prendergast, PJ, Campbell, V, Coey, JMD, Effects of static magnetic fields on Primary cortical neurons, Physica Scripta, T118, 2005, p205 - 207 Journal Article, 2005 DOI URL

Nowlan, N.C. , Murphy P. and Prendergast, P.J., Mechanical Stimuli Resulting From Embryonic Muscle Contractions Promote Avian Periosteal Bone Collar Formation, Proceedings of the 2007 Summer Bioengineering Conference of the American Society of Mechanical Engineering, 2007 Summer Bioengineering Conference of the American Society of Mechanical Engineering, American Society of Mechanical Engineering, 2005, pp833-834 Conference Paper, 2005

M Moretti, D Wendt, S C Dickinson, T J Sims, A P Hollander, D J Kelly, P J Prendergast, M Heberer, I Martin, Effects of in vitro pre-culture on the in vivo development of human engineered cartilage in an ectopic model, Tissue Engineering, 11, (9-10), 2005, p1421 - 1428 Journal Article, 2005 DOI URL

Scannell, PT, Prendergast PJ, Simulation of changes in bone around a hip prosthesis, Engineers Journal, 59, 2005, p319 - 324 Journal Article, 2005

Lally, C, Dolan, F, Prendergast, PJ, Cardiovascular stent design and blood vessel stress: a finite element analysis, Journal of Biomechanics, 38, (8), 2005, p1574 - 1581 Journal Article, 2005 DOI URL

McNamara LM, Prendergast PJ, Schaffler MB, Bone tissue material properties are altered during osteoporosis, Journal of Musculoskeletal and Neuronal Interactions, 5, (4), 2005, p342 - 343 Journal Article, 2005 TARA - Full Text URL

Nowlan, N.C., Murphy P. and Prendergast, P.J, Computation of stresses in the growing embryonic chick limb, Proceedings of the 2 nd International Conference on Computational Bioengineering , 2nd International Conference on Computational Bioengineering , edited by Rodrigues, et al., , 2, IST Press. Lisbon., 2005, pp861-872 Conference Paper, 2005

Kelly, DJ, Prendergast PJ, Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects, Journal of Biomechanics, 38, 2005, p1413 - 1422 Journal Article, 2005

Murphy, LA, Prendergast, PJ, Acromion-fixation of glenoid components in total shoulder arthroplasty, Journal of Biomechanics, 38, (8), 2005, p1702 - 1711 Journal Article, 2005 URL DOI

McGarry JG, Klein-Nulend, J, Prendergast, PJ, The effect of cytoskeletal modulation of pulsatile fluid flow-induced Nitric Oxide and Prosteoglandin E2 release in osteocytes and osteoblasts, Biochemical and Biophysical Research Communications, 330, 2005, p342 - 348 Journal Article, 2005

Lennon, A.B.; Britton, J.R.; Vard, J.; Byrne, D. & Prendergast, P.J., Simulation of creep and fatigue damage accumulation can predict clinical performance of total hip femoral components, Annual Symposium Irish Society for Scientific and Engineering Computation, Annual Symposium Irish Society for Scientific and Engineering Computation, Cork, Ireland, 2005, pp19 Conference Paper, 2005

Andreykiv, A, Prendergast, PJ, van Keulen, F, Swieszkowski, W, Rozing, PM, Bone ingrowth simulation for concept glenoid component design, Journal of Biomechanics, 38, (5), 2005, p1023 - 1033 Journal Article, 2005 DOI URL

McNamara, LM, Prendergast, PJ, Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis, European Journal of Morphology, 42, (1-2), 2005, p99 - 109 Journal Article, 2005 URL DOI

DJ Kelly and PJ Prendergast, Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects, Journal of Biomechanics, 38, (7), 2005, p1413 - 1422 Journal Article, 2005 URL DOI TARA - Full Text

Nowlan, NC, Prendergast PJ, Evolution of mechanoregulation of bone growth will lead to non-optimal bone phenotypes, Journal of Theoretical Biology, 235, (3), 2005, p408 - 418 Journal Article, 2005 DOI TARA - Full Text URL

Moretti, M, Wendt, D, Dickinson, S, Hollander, AP, Kelly, DJ, Prendergast, PJ, Herber, M, Martin, I, Effects of in vitro pre-culture on the in vivo development of human engineered cartilage, Tissue Engineering, 11, (9-10), 2005, p1421 - 1428 Journal Article, 2005 DOI URL

Nowlan, N.C. and Prendergast P.J., Evolution of Mechanoregulation of Bone Growth Will Lead to Non-optimal Bone Phenotypes, Journal of Theoretical Biology, 235, (3), 2005, p408 - 418 Journal Article, 2005 DOI

DJ Kelly and PJ Prendergast, Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis, Medical & Biological Engineering & Computing, 45, (1), 2004, p9 - 13 Journal Article, 2004 URL DOI

The state-of-the-art in cartilage bioreactors. in, editor(s)PJ Prendergast, PE McHugh , Topics in Bio-Mechanical Engineering, Dublin, Trinity Centre for Bioengineering & National Centre for Biomedical Engineering Science, 2004, pp94 - 146, [McMahon LA, Barron V, Prina-Mello A, Prendergast PJ ] Book Chapter, 2004

Britton, JR, Lyons, CG, Prendergast, PJ, Measurement of the relative motion between an implant and bone under cyclic loading, Strain, 40, 2004, p193 - 202 Journal Article, 2004

Farrell, E., O'Brien, F., Prendergast, P. J., Campbell, V. A., Mesenchymal stem cells and bioengineering, Journal of Anatomy, 205, (6), 2004, p504 - 536 Journal Article, 2004 URL

Modelling the response of cells to mechanical stimulation in, editor(s)Józef Joachim Telega , Modelling in Biomechanics: Lecture Notes 19 of AMAS, Warsaw, Institute of Fundamental Technological Research, 2004, pp159-189 , [PJ Prendergast, DJ Kelly, JG McGarry.] Book Chapter, 2004

Kelly, DJ, Prendergast, PJ, Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis, Medical and Biological Engineering and Computing, 42, 2004, p9 - 13 Journal Article, 2004 TARA - Full Text

Moretti, M, Barron, V, Prina Mello, A, Reid, AJ, Prendergast, PJ, Endothelial cell alignment on cyclically-stretched silicone surfaces, Journal of Materials Science: Materials in Medicine, 15, 2004, p1159 - 1164 Journal Article, 2004

Moretti M., Prina_Mello A., Reid A.J., Barron V., Prendergast P.J. 2004. , Endothelial cell alignment on cyclically-stretched silicone surfaces., Journal of Materials Science: Materials in Medicine , 15, (10), 2004, p1159 - 1164 Journal Article, 2004 DOI URL

McGarry, JG, Prendergast, PJ, A three-dimensional computational model of an adherent eukaryotic cell, European Cells and Materials, 7, 2004, p27 - 34 Journal Article, 2004

A scheme for investigating the evolution of bone remodelling laws in, Book of Abstracts of the International Workshop for Numerical Models of Bone Adaptation and Repair , International Workshop for Numerical Models of Bone Adaptation and Repair , 2004, pp22 - [Nowlan, N.C. and Prendergast, P.J. ] Book Chapter, 2004

DJ Kelly, PJ Prendergast, A Mechanobiological analysis of osteochondral defect repair, Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, California, 2004, 2004 Poster, 2004

Lennon, A.B.; McCormack, B.A.O. & Prendergast, P.J., Implications of acrylic bone cement porosity for computational modelling of variable failure of cemented joint reconstructions, Proceedings of 14th EORS Meeting, 14th EORS Meeting, Amsterdam, Netherlands, 2004 Conference Paper, 2004

Lally, C, Reid, AJ, Prendergast, PJ, Elastic behaviour of porcine coronary arteries under uniaxial and equibiaxial tension, Annals of Biomedical Engineering, 32, 2004, p1355 - 1364 Journal Article, 2004

Prendergast, PJ, Lally, C, Daly, S, Lee, TC, Quinn, D, Dolan, F, Analysis of prolapse in cardiovascular stents: a constitutive equation for vascular tissue and finite element modelling, Journal of Biomechanical Engineering , 125, 2003, p692-699 Journal Article, 2003

Prina-Mello A., Volkov Y., Kelleher D., Prendergast P.J., Comparative locomotory behaviour of T Lymphocytes versus T Lymphoma cells on flat and grooved surfaces., Annals of Biomedical Engineering. , 31, 2003, p1106 - 1113 Journal Article, 2003 DOI

Kelly, DJ, Prendergast, PJ, Blayney, AW, The effect of prosthesis design on the vibration of reconstructed ossicular chain: a comparative finite element analysis of four prostheses, Otology and Neurotology , 24, 2003, p11-19 Journal Article, 2003

Stolk J, Maher SA, Verdonschot N, Prendergast PJ, Huiskes R, Can finite element models detect clinically inferior cemented hip implants?, Clinical orthopaedics and related research, (409), 2003, p138-50 Journal Article, 2003

Britton, JR, Walsh, LA, Prendergast, PJ, Mechanical simulation of muscle loading on the proximal femur: analysis of cemented femoral component migration with and without muscle loading , Clinical Biomechanics, 18, 2003, p637-646 Journal Article, 2003

Lennon, AB, McCormack, BAO, Prendergast, PJ, The relationship between cement fatigue damage and implant surface finish in proximal femoral prostheses, Medical Engineering and Physics, 25, (10), 2003, p833-841 Journal Article, 2003 DOI

Stolk, J, Verdonschot, N, Murphy, BP, Prendergast, PJ, Huiskes, R, Finite element simulation of anisotropic damage accumulation and creep in acrylic bone cement, Engineering Fracture Mechanics, 71, 2003, p513-528 Journal Article, 2003

Prina Mello, A, Volkov, Y, Delleher, D, Prendergast, PJ, Comparative locomotory behavious of T lymphocytes and T lymphoma cells on flat and grooved surfaces, Annals of Biomedical Engineering, 31, 2003, p1106-1113 Journal Article, 2003

Kelly, DJ, Prendergast, PJ, Mechanical properties of the cartilage component in tissue-engineered cartilage constructs determined by poroelastic finite element modelling, Medical and Biological Engineering and Computing, 2003 Journal Article, 2003

Lennon, A.B. And Prendergast, P.J., Aspects of the mechanical performance of PMMA as an orthopaedic fixation cement, Proceeding of the Ninth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Ninth Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Ireland, 25-26 January, edited by FitzPatrick, D.P., McCormack, B.A.O., McCormack, D , 2003, ppXX Conference Paper, 2003

Kelly, DJ, Blayney, AW, Prendergast, PJ, Biomechanics of ossiculoplasty, CME Bulletin Otorhinolaryngology Head and Neck Surgery, 7, 2003, p64 - 66 Journal Article, 2003 TARA - Full Text

Kelly, DJ, Blayney, AW, Prendergast, PJ, Biomechanics of ossiculoplasty, CME Bulletin Otorhinolaryngology Head and Neck Surgery, 7, 2003, p64 - 66 Journal Article, 2003 URL

Swieszkowski, W, Bednarz, P, Prendergast, PJ, Contact stresses in the glenoid component in total shoulder arthroplasty, Journal of Engineering in Medicine; Proceedings of the Institution of Mechanical Engineers, Part H - 217, 2003, p49-57 Journal Article, 2003

Murphy, BP, Prendergast, PJ, Multi-axial fatigue of orthopaedic bone cement - experiments with tubular specimens, Journal of Materials Science: Materials in Medicine, 14, 2003, p857-861 Journal Article, 2003

Kelly, D J; Prendergast, P J; Blayney, A W, The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses, Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology, 24, (1), 2003, p11 - 19 Journal Article, 2003 TARA - Full Text URL

Prina_Mello A., Bari M.A. Prendergast, P.J. , A comparison of excimer laser etching and dry etching process for surface fabrication of biomaterials., Journal of Materials Processing Technology , 124, 2002, p284 - 292 Journal Article, 2002 URL

Murphy, LA, Prendergast, PJ, Resch, H, Structural analysis of an offset-keel design glenoid component compared to a centre-keel design, Journal of Shoulder and Elbow Surgery, 10, 2002, p568-579 Journal Article, 2002

Lacroix, D, Prendergast, PJ, A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading, Journal of Biomechanics, 35, 2002, p1163 - 1171 Journal Article, 2002

Lacroix, D, Prendergast, PJ, Li, G, Marsh, D, Biomechanical model to simulate tissue differentiation and bone regeneration: application to fracture healing, Medical & Biomechanical Engineering & Computing, 40, 2002, p14-21 Journal Article, 2002

Murphy, BP, Prendergast, PJ, The relationship between stress, porosity, and nonlinear damage accumulation in acrylic bone cement, Journal of Biomedical Materials Research, 59, 2002, p646-654 Journal Article, 2002

Prendergast, PJ, Mechanics applied to skeletal ontogeny and phylogeny, Meccanica, 37, 2002, p317-334 Journal Article, 2002 TARA - Full Text DOI

Lally, C., Prendergast, P.J., Lennon, A.B., Quinn, D., Dolan, F, Finite element analysis of tissue prolapse within intravascular stents. Calculations using a single repeating unit of a stent and a 3D model of a stent, 13th Conference of the European Society of Biomechanics, Wroclaw, Poland, 2002 Conference Paper, 2002

Mello, AP, Bari, MA, Prendergast, PJ, A comparison of excimer laser etching and dry etching process for surface fabrication of biomaterials, Journal of Materials Processing Technology, 124, 2002, p284 - 292 Journal Article, 2002

Lacroix, D, Prendergast, PJ, Three-dimensional simulation of fracture repair in the human tibia, Computer Methods in Biomechanics and Biomedical Engineering, 5, 2002, p369 - 376 Journal Article, 2002

Van Doorn, WJ, Van Biezen, FC, Prendergast, PJ, Fracture of an exeter stem 3 years after impaction allografting - a case report, Acta Orthopaedica Scandinavica, 73, 2002, p111-113 Journal Article, 2002

Meccanica - Special Issue on "Mechanics of Tissues and Implants", 37, 4/5, (2002), 315 - 488p, Prendergast, PJ, Contro, R, [Guest Eds.] Journal, 2002

Lennon, AB, Prendergast, PJ, Residual stress due to curing can initiate damage in porous bone cement: experimental and theoretical evidence, Journal of Biomechanics, 35, (3), 2002, p311 - 321 Journal Article, 2002 DOI

Maher, SA, Prendergast, PJ, Discriminating the loosening behaviour of cemented hip prostheses using measurements of migration and inducible displacement, Journal of Biomechanics, 35, 2002, p257 - 265 Journal Article, 2002

Prendergast, PJ, McCormack, BAO, ESB Keynote Lecture - Dublin 2000 - Outcomes of the 12th Conference of the European Society of Biomechanics, Editorial, 2002, - 399-400 Miscellaneous, 2002

Prendergast, PJ, Murphy, BP, Taylor, D, Fatigue testing of orthopaedic bone cement: a comment on Cristofolini et al., Fatigue and Fracture of Engineering Materials and Structures, 25, 2002, p315 - 316 Journal Article, 2002

Prendergast, PJ, Maher, SA, Issues in pre-clinical testing of implants, Journal of Materials Processing Technology, 118, 2002, p337-342 Journal Article, 2002

Murphy, BJ, Prendergast, PJ, The relationship between stress, porosity and on-linear damage accumulation in acrylic bone cement, Journal of Biomedical Biomaterials Research, 59, 2001, p646-654 Journal Article, 2001

Prendergast, PJ, Maher, SA, Issues in pre-clinical testing of implants, Journal of materials processing technology, 118, 2001, p337-342 Journal Article, 2001

Maher, SA, Prendergast, PJ, Lyons, CG, Measurement of the migration of a cemented hip prosthesis in an in-vitro test, Clinical Biomechanics, 16, 2001, p307-314 Journal Article, 2001

Lennon, A.B. and Prendergast, P.J., Finite element modelling of the formation of pre-load damage in cement mantles of orthopaedic joint replacements, Summer Bioengineering Conference, Snowbird, Utah, June 27 - July 1, 2001 Conference Paper, 2001

Lennon, AB, Prendergast, PJ, Evaluation of cement stresses in finite element analyses of cemented orthopaedic implants, Journal of Biomechanical Engineering, 123, (6), 2001, p623-628 Journal Article, 2001 DOI

Lennon, A.B., Murphy, B.P., and Prendergast, P.J. , Modelling fatigue failure of PMMA specimens as a stochastic process , Computer Methods in Biomechanics & Biomedical Engineering-4, Rome, Italy, 2001, edited by J. Middleton, M.L. Jones, N.G. Shrive, and G.N. Pande , 2001, ppCDROM Conference Paper, 2001

Murphy, LA, Prendergast, PJ, Resch, H, Structural analysis of an offset-keel design glenoid component compared to a centre-keel design, Journal of Shoulder and Elbow Surgery, 10, 2001, p568-679 Journal Article, 2001

Lennon, A.B. and Prendergast, P.J., Can implant surface finish affect cement damage accumulation around femoral stems in total hip replacement?, Proceedings of 7th Annual Conference of Section of the Royal Academy of Medicine in Ireland, Bioengineering in Ireland, Arklow , Co. Louth, Ireland, 27-28 January , edited by Fitzpatrick, D.P. and Carr, A.J. , Royal Academy of Medicine in Ireland, 2001, 33 Conference Paper, 2001

Prendergast, PJ, The functional performance of orthopaedic bone cement, Key Engineering Materials, 198-1, 2001, p291-299 Journal Article, 2001

Maher, SA, Prendergast, PJ, Reid, AJ, Waide, DV, Toni, A, Design and validation of a machine for reproducible precision insertion of femoral hip prostheses for preclinical testing, Journal of Biomechanical Engineering-Transactions of the ASME, 122, 2001, p203-207 Journal Article, 2001

Prendergast, PJ, An analysis of theories in biomechanics, Engineering Transactions, 49, 2001, p117-133 Journal Article, 2001

van der Meulen, MCH, Prendergast, PJ, Mechanics in skeletal development, adaptation and disease, Philosophical Transactions of the Royal Society of London Series A - Mathematical Physical and Engineering Sciences, 358, 2000, p565-578 Journal Article, 2000

Prendergast, PJ, Kelly, DJ, Rafferty, M, Blayney, AW, The effect of ventilation tubes on stresses and vibration motion in the tympanic membrane: a finite element analysis, Clinical Otolaryngology, 24, 2000, p542-548 Journal Article, 2000

Lacroix, D, Murphy, LA, Prendergast PJ, Three-dimensional finite element analysis of glenoid replacement prostheses: a comparison of keeled and pegged anchorage systems, Journal of Biomechanical Engineering-Transactions of the ASME, 123, 2000, p430-436 Journal Article, 2000

Lennon, A.B., Prendergast, P.J., Whelan, M.P., Kenny, R.P., Cavalli, C, Modelling of temperature history and residual stress generation due to curing in polymethylacrylate, Proceedings of the 12th Conference of the European Society of Biomechanics, 12th Conference of the European Society of Biomechanics, Dublin, Royal Academy of Medicine in Ireland, 2000, pp253 Conference Paper, 2000

Lennon, A.B.; Prendergast, P.J.; Lacroix, D.; Revie, I. & Pfleiderer, M., Stress analysis of cement mantle of a polished femoral hip replacement, Proceedings of the 12th Conference of the European Society of Biomechanics, 12th Conference of the European Society of Biomechanics, Dublin, Royal Academy of Medicine in Ireland, 2000, pp189 Conference Paper, 2000

Whelan, M.P., Kenny, R.P., Cavalli, C., Lennon, A.B., and Prendergast, P.J., Application of optical fibre Bragg grating sensors to the study of PMMA curing, Proceedings of the 12th Conference of the European Society of Biomechanics, 12th Conference of the European Society of Biomechanics, Dublin, Royal Academy of Medicine in Ireland, 2000, pp252 Conference Paper, 2000

Maher, SA, Prendergast, PJ, Reid, AJ, Waide, DV, Toni, A, Design and validation of a machine for reproducible precision insertion of femoral hip prostheses for pre-clinical testing, Journal of Biomechanical Engineering, 123, 2000, p203-7 Journal Article, 2000

Murphy, BP, Prendergast, PJ, On the magnitude and variability of the fatigue strength of acrylic bone cement, International Journal of Fatigue, 22, 2000, p855-864 Journal Article, 2000

Ferris, P, Prendergast, PJ, Middle-ear dynamics before and after ossicular replacement, Journal of Biomechanics, 33, 2000, p581-590 Journal Article, 2000

Prendergast, PJ, Gorey, TF, Collaborative bioengineering: clinical activities in Ireland, 1999, - 2-2 Miscellaneous, 1999

Murphy, BP, Prendergast, PJ, Measurement of non-linear micro-crack accumulation rates in polymethylmethacrylate bone cement under cyclic loading, Journal of Materials Science: Materials in Medicine, 10, 1999, p779-81 Journal Article, 1999

Prendergast, P J; Kelly, D J; Rafferty, M; Blayney, A W, The effect of ventilation tubes on stresses and vibration motion in the tympanic membrane: a finite element analysis, Clinical Otolaryngology And Allied Sciences, 24, (6), 1999, p542 - 548 Journal Article, 1999 DOI URL

McCormack, BAO, Prendergast, PJ, Microdamage accumulation in the cement layer of hip replacements under flexural loading, Journal of Biomechanics, 32, 1999, p467-475 Journal Article, 1999

McCormack, BAO, Prendergast, PJ, ODwyer, B, Fatigue of cemented hip replacements under torsional loads, Fatigue & Fracture of Engineering Materials & Structures, 22, 1999, p33-40 Journal Article, 1999

Prendergast, PJ, Lee, TC, On a wing and a prayer: the biomechanics of the Rev. Dr. Samuel Haughton (1821-1897), Journal of the Irish Colleges of Physicians and Surgeons, 28, 1999, p38-43 Journal Article, 1999

Prendergast, PJ, Beverland, DE, Blayney, AW, Dunne, NJ, Gorey, TF, Grace, PA, McCormack, BAO, McGloughlin, T, OConnell, PR, Orr, JF, Modelling medical devices: the application of bioengineering in surgery, Irish Journal of Medical Science, 168, 1999, p3-7 Journal Article, 1999

McCormack BA, Prendergast PJ, Microdamage accumulation in the cement layer of hip replacements under flexural loading., Journal of biomechanics, 32, (5), 1999, p467-75 Journal Article, 1999

Prendergast, PJ, Kelly, D, Rafferty, M, Blayney AW, The effect of ventilation tubes on stresses and vibration motion in the tympanic membrane: a finite element analysis, Clinical Otolaryngology, 24, 1999, p542-48 Journal Article, 1999

Prendergast, PJ, Birthistle, P, Waide, DV, Kumar, NVG, An investigation of the performance of biostop G and Hardinge bone plugs, Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine, 213, 1999, p361-365 Journal Article, 1999

Prendergast, PJ, Ferris, P, Rice, HJ, Blayney, AW, Vibro-acoustic modelling of the outer and middle ear using the finite-element method, Audiology and Neuro-Otology, 4, 1999, p185-191 Journal Article, 1999

Murphy, BP, Prendergast, PJ, Measurement of non-linear microcrack accumulation rates in polymethylmethacrylate bone cement under cyclic loading, Journal of Materials Science-Materials in Medicine, 10, 1999, p779-781 Journal Article, 1999

Lennon, A.B., McCormack, B.A.O., and Prendergast, P.J., Issues in modelling mechanical failure of cemented orthopaedic joint replacements., Annual Symposium Irish Society for Scientific and Engineering Computation, Dublin, May , 1998 Conference Paper, 1998

Lacroix, D, Prendergast, PJ, Stress analysis of glenoid component designs for shoulder arthroplasty, Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine, 211, 1998, p467-474 Journal Article, 1998

Lennon, A.B. McCormack, B.A.O., and Prendergast, P.J., Calculation of the maximum transient stresses and 'locked-in' residual stresses in bone cement in THR., Bioengineering in Ireland/TUBES Joint Conference, Dundalk, Co. Louth, February , 1998 Conference Paper, 1998

McCormack, BAO, Walsh, CD, Wilson, SP, Prendergast, PJ, A statistical analysis of microcrack accumulation in PMMA under fatigue loading: applications to orthopaedic implant fixation, International Journal of Fatigue, 20, 1998, p581-593 Journal Article, 1998

Simon P. Wilson, B.A.O. McCormack, C.D. Walsh and P.J. Prendergast, A statistical analysis of microcrack accumulation in PMMA under fatigue loading: applications to orthopaedic implant fixation, International Journal of Fatigue, 20, (3), 1998, p581 - 593 Journal Article, 1998 DOI

Huiskes, R, Vandriel, WD, Prendergast, PJ, Soballe, K, A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation, Journal of Materials Science-Materials in Medicine, 8, 1997, p785-788 Journal Article, 1997

Lacroix, D, Prendergast, PJ, Stress analysis of glenoid component design for shoulder arthroplasty, Journal of Engineering in Medicine, Proceedings of the Institution of Mechanical Engineers, Part H - 211, 1997, p467-74 Journal Article, 1997

Taylor D, Prendergast PJ, A model for fatigue crack propagation and remodelling in compact bone., Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, 211, (5), 1997, p369-75 Journal Article, 1997

Prendergast, PJ, Finite element analysis in tissue mechanics and orthopaedic implant design, Clinical Biomechanics, 12, 1997, p343-368 Journal Article, 1997

Taylor, D, Prendergast, PJ, A model for fatigue crack propatation and remodelling in compact bone, Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineerign in Medicine, 211, 1997, p369-375 Journal Article, 1997

Prendergast, PJ, Biophysical stimuli on cells during tissue differentiation at implant interfaces, Journal of Biomechanics, 30, 1997, p539-548 Journal Article, 1997

Prendergsast, PJ, The bioengineering design forum: developing an innovation network, Industry and Higher Education, 11, 1997, p116-9 Journal Article, 1997

Lennon, A.B., McCormack, B.A.O. & Prendergast, P.J, Structural analysis of physical models of THRs using analytical and finite element methods., Computer Methods in Biomechanics & Biomedical Engineering-2, Barcelona, Spain, 1997 Conference Paper, 1997

McNamara, BP, Taylor, D, Prendergast PJ, Computer prediction of adaptive bone-remodelling around noncemented femoral prostheses: the relationship between damage-based and strain-based algorithms, Medical Engineering and Physics, 19, 1997, p454-63 Journal Article, 1997

Weinans, H, Prendergast, PJ, Tissue adaptation as a dynamical process far from equilibrium, Bone, 19, (2), 1996, p143-149 Journal Article, 1996 DOI URL

Prendergast, PJ, Huiskes, R, Microdamage and osteocyte-lacuna strain in bone: a microstructural finite element analysis, Journal of Biomechanical Engineering, 118, (2), 1996, p240-6 Journal Article, 1996 URL DOI

Prendergast, PJ, Huiskes, R, Finite element analysis of fibrous tissue morphogenesis: a study of the 'osteogenic index' using a biphasic approach, Mechanics of composite materials, 32, 1996, p209-18 Journal Article, 1996

McCormack, BAO, Prendergast, PJ, Gallagher, DG, An experimental study of damage accumulation in cemented hip prostheses, Clinical Biomechanics, 11, (4), 1996, p214-219 Journal Article, 1996 URL DOI

Prendergast, PJ, van Driel, WD, Kuiper, JH, A comparison of finite element codes for the solution of biphasic poroelastic problems, Journal of Engineering in Medicine; Proceedings of the Institution of Mechanical Engineers, Part H 210, 1996, p124-130 Journal Article, 1996 URL

McCormack, BAO, Prendergast, PJ, An analysis of crack propagation paths at implant/bone-cement interfaces, Journal of Biomechanical Engineering-Transactions of the ASME, 118, (4), 1996, p579-585 Journal Article, 1996 DOI URL

Prendergast, PJ, The biomechanics of Wolff's Law - recent advances, Irish Journal of Medical Science, 164, 1995, p152-154 Journal Article, 1995

Prendergast, PJ, Taylor, D, Prediction of bone adaptation using damage accumulation, Journal of Biomechanics, 27, (8), 1994, p1067-1076 Journal Article, 1994 URL DOI

Prendergast, PJ , Finite element models in tissue mechanics and orthopaedic implant design , Journal of Biomechanics , 12, (6), 1994, p343-366 Journal Article, 1994 DOI URL

Prendergast, PJ, Toland, SJ, Corrigan, JP, Finite element analysis and experimental testing of external fixator frame designs, Journal of Engineering in Medicine, Proceedings of the Institution of Mechanical Engineers, Part H, 208, 1994, p103-10 Journal Article, 1994 DOI URL

Culleton, TP, Prendergast, PJ, Taylor, D, Fatigue failure in the cement mantle of an artificial hip joint, Clinical Materials, 12, (2), 1993, p95-102 Journal Article, 1993 URL DOI

McNamara, BP, Prendergast, PJ, Taylor, D, Prediction of bone adaptation in the ulnar-osteotomized sheeps forelimb using an anatomical finite-element model, Journal of Biomedical Engineering, 14, (3), 1992, p209-216 Journal Article, 1992 URL

Prendergast, PJ, Taylor, D, The design of intramedullary prostheses to prevent bone loss: predictions based on damage-stimulated remodelling, Journal of Biomedical Engineering, 14, (6), 1992, p499-506 Journal Article, 1992 URL DOI

Prendergast, PJ, Taylor, D, Stress-analysis of the proximomedial femur after total hip-replacement, Journal of Biomedical Engineering, 12, (5), 1990, p379-382 Journal Article, 1990 DOI URL

Prendergast, PJ, Monaghan, J, Taylor, D, Materials selection in the artificial hip joint using finite element stress analysis, Clinical Materials, 4, (2-3), 1989, p361-76 Journal Article, 1989 URL DOI

Finite element modelling in orthopaedic implant design in, editor(s)RW Lindsey, Z Gugala , Orthopaedic Implants: Applications, Complications and Management, [Prendergast, PJ, Taylor, M] Book Chapter,

Non-Peer-Reviewed Publications

Simulation of in-stent restenosis for the design of cardiovascular stents in, G. Holzpafel & R. Ogden , Mechanics of Biological Tissue, Springer, 2006, pp255 - 267, [Lally, C, Prendergast, PJ] Book Chapter, 2006

Experiment and computation in mechanobiology, with new applications in cardiology and evolution in, editor(s)J. Piekarski , Tissue Remodelling, Warsaw, Centre of Excellence for Applied Biomedical Modelling and Diagnostics, 2005, pp219 - 240, [Prendergast, PJ, Nowlan, NC, Lally C] Book Chapter, 2005

Analysis of joint and muscle loads in, editor(s)Mow, VC, Huiskes, R , Basic Orthopaedic Biomechanics and Mechanobiology, Lippencodt Williams & Wilkins, 2005, [Prendergast, PJ, van der Helm, FCT, Duda, GN] Book Chapter, 2005

Modelling the response of cells to mechanical stimulation in, editor(s)Józef Joachim Telega , Modelling in Biomechanics: Lecture Notes 19 of AMAS (Polish Academy of Sciences), Warsaw, Institute of Fundamental Technological Research, 2005, pp159 - 189, [Prendergast, PJ, Kelly, DJ, McGarry, JG ] Book Chapter, 2005

Mechanobiology: Experiment and Computation in, editor(s)PJ Prendergast, PE McHugh , Topics in Bio-Mechanical Engineering, Dublin, Trinity Centre for Bioengineering & National Centre for Biomedical Engineering Science, 2004, pp41 - 57, [Prendergast, PJ] Book Chapter, 2004

Computational mechanobiology in, editor(s)M Cerrolaza, M Doblaré, G Martínez, B Calvo , Computational Bioengineering: Current Trends and Applications, Imperial College Press, 2004, [Prendergast, PJ] Book Chapter, 2004

Prendergast PJ, McHugh PE (Editors), Topics in Bio-Mechanical Engineering, Dublin, Trinity Centre for Bioengineering & National Centre for Biomedical Engineering Science, 2004, 1 - 249pp Book, 2004

What a piece of work is a man in, editor(s)EP O'Neill , New Irish Writing in Science, Dublin, Trinity College Dublin, 2003, [Prendergast, PJ] Book Chapter, 2003

Prendergast, PJ, Life and Limb: The Bioengineering of Prostheses and Implants (R.I.A. Parsons Medal Lecture), Dublin, Trinity College Dublin, 2003, 30pp Book, 2003

Bone prostheses and implants in, editor(s)Cowin, SC , Handbook of Bone Mechanics, Boca Raton, CRC Press, 2001, pp35.1-35.39 , [Prendergast, PJ] Book Chapter, 2001

Prendergast, PJ, Biomechanical Techniques for Pre-Clinical Testing of Prostheses and Implants, Warsaw, Institute of Fundamental Technological Research, 2001, 67pp Book, 2001

Skeletal structure: synthesis of mechanics and cell biology in, editor(s)JMT Thompson , Visions of the Future: Chemistry and Life Science, Cambridge University Press, 2001, pp113 - 125, [van der Meulen, MCH, Prendergast PJ] Book Chapter, 2001

Mechanics of Bone Regeneration in, editor(s)Cowin, SC , Bone Mechanics Handbook, Boca Raton, Crc Press, 2001, pp32.1-32.13 , [Prendergast, PJ, van der Meulen, MCH] Book Chapter, 2001

Prendergast, PJ, Murphy, LA, Selection of glenoid prosthesis-type based on an assessment of glenoid bone quality, Proceedings of the 3rd Conference of the International Shoulder Group, edited by Chadwick, EKJ, Veeger, HEJ, van der Helm, FCT, Nagels, J , (ISBN 90-4070-2268-4), DUP Science, 2001, pp83-86 Conference Paper, 2001

Prendergast, PJ, Lee, TC, Carr AJ(ed.), 12th Conference of the European Society of Biomechanics, Dublin, 2000, Royal Academy of Medicine in Ireland, 2000, 476 + xvii p Proceedings of a Conference, 2000

Prendergast, PJ, Biomechanics in Ireland and Europe, Proceedings of the 12th Conference of the European Society of Biomechanics, Dublin, edited by Prendergast, PJ, Lee, TC, Carr, AJ , Royal Academy of Medicine in Ireland, 2000, pp1-4 Conference Paper, 2000

Prendergast, PJ, Maher, SA, Issues in pre-clinical testing of implants, Proceedings Advances in Materials and PRocessing Technologies 99 & 16th Irish Manufacturing Conference, Dublin, edited by MSJ Hashmi, L Looney , Dublin City University, 1999, pp1195-1202 Conference Paper, 1999

Tissue adaptation as a discrete-dynamical process in time and space in, editor(s)Pedersen, P, Bendsoe, M , Synthesis in Bio Solid Mechanics, Dordrecht, Kluwer Academic Publishers, 1999, pp321-332 , [Prendergast, PJ, Weinans, H] Book Chapter, 1999

Prendergast, PJ, Dickson, GR(ed.), The Ulster Biomedical Engineering Society Scientific Meeting, Proceedings of Bioengineering in Ireland, Trinity College, Dublin, 1998, 73 + viii p Proceedings of a Conference, 1998

Lacroix, D, Prendergast, PJ, Murray, R, McAlinden, S, D'Arcy, E, The use of quantitative computed tomography to generate a finite element model of the scapula bone, Proceedings of the 14th Irish Manufacturing Conference: Sustainable Technology for Manufacturing Industries, Dublin, September 1997, edited by Monaghan, J, Lyons, G , Trinity College Dublin, 1997, pp257-64 Conference Paper, 1997

Prendergast, PJ, A non-linear dynamical analysis of the bone-remodelling equations, ASME/AICHE/ASCE Summer Bioengineering Conference, edited by Chandran, KB, Vanderby, R, JR, Hefzy, MS , American Society of Mechanical Engineers, 1997, pp493-4 Conference Paper, 1997

Mathematical modelling of microdamage in bone remodelling and adaptation in, editor(s)Odgaard, A, Weinans, H , Bone Structure and Remodelling, Singapore, World Scientific Publishers, 1995, pp213-24 , [Prendergast, PJ, Huiskes, R] Book Chapter, 1995

Prendergast, PJ, McCormack, BAO, Taylor, D, Innovation initiatives in bioengineering: The Design Forum, Proceedings 11th Irish Manufacturing Conference, Lean Production: From Concept to Product, Belfast, edited by A Storrer , Queen's University of Belfast, 1994, pp319-325 Conference Paper, 1994

Prendergast, PJ, Huiskes, R, The osteon-debonding hypothesis of haversian bone remodelling: osteocytes or bone-lining cells as sensors?, Advances in Bioengineering, edited by Askew, MJ , American Society of Mechanical Engineers, 1994, pp263-4 Conference Paper, 1994

Culleton, TP, Prendergast, PJ, Taylor, D, Problems associated with experimental acelerated fatigue testing of the artificial hip joint, Proceedings 8th Irish Materials Forum, Key Engineering Materials, 86-87, 1993, pp199-205 Conference Paper, 1993

Prendergast, PJ, Weinans, H, Huiskes, R, Taylor, D, Bone structure and the dynamics of bone adaptation in response to accumulative damage, Proceedings 8th Irish Materials Forum, Key Engineering Materials, 86-87, 1993, pp187-192 Conference Paper, 1993

Prendergast, PJ, McNamara, BP, Taylor, D, A model to predict bone adaptation based on accumulative damage and repair: finite element simulations, Recent advances in computer methods in Biomechanics and biomedical engineering, edited by Middleton, J, Pande, G, Williams, KR , IBJ Publishers: Swansea, 1993, pp40-49 Conference Paper, 1993

Prendergast, PJ, McCormack, B, Gunawardhana, T, Taylor, D, The effect of prosthesis orientation on stress shielding using finite element analysis: indications as to bone remodelling, Interfaces in Medicine and Mechanics II, edited by Williams, KR, Toni, A, Middleton, J, Pallotti, G , Elsevier Applied Science, 1991, pp329-339 Conference Paper, 1991

Henn, G, Prendergast, PJ, Taylor, D, An assessment of a particulate composite for use in hip joint prostheses, Proceedings of 6th Irish Materials Forum, Advanced Engineered Materials, Dublin, Parsons Press, 1990, pp283-300 Conference Paper, 1990

Prendergast, PJ, Taylor, D, A continuum damage approach to bone remodelling, Proceedings of 6th Irish Materials Forum, Advanced Engineered Materials, Dublin, Parsons Press, 1990, pp301-327 Conference Paper, 1990

Research Expertise

Description

His research interests are in biomechanics and implant design, and in tissue engineering and mechanobiology.

Projects

  • Title
    • Computer simulation of biodegradation scaffolds: Validation against experiments and implementation for tissue engineering
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2009
  • Date To
    • 2011
  • Title
    • An International Symposium entitled "Innovation: the third pillar of Irish Higher education?"
  • Funding Agency
    • NAIRTL
  • Date From
    • 2009
  • Date To
    • 2010
  • Title
    • Mechanoresponsiveness of mesenchymal stem cells with ageing
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2008
  • Date To
    • 2010
  • Title
    • Mechanoregulation of patterning genes during development of the embryonic skeleton: growth and differentiation in the absence of muscle contractions.
  • Funding Agency
    • Wellcome Trust
  • Date From
    • 2008
  • Date To
    • 2010
  • Title
    • Computational Mechanobiology: fundamental advances and implementation for medical device engineering
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2007
  • Date To
    • 2010
  • Title
    • Evolution and Bone Morphology
  • Funding Agency
    • Embark Initiative
  • Date From
    • 2006
  • Date To
    • 2008
  • Title
    • Finite Element Modelling in Biomechanics & Mechanobiology Workshop
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2006
  • Date To
    • 2007
  • Title
    • Collaborative Project Grant
  • Funding Agency
    • French Embassy Dublin
  • Date From
    • 2007
  • Date To
    • 2007
  • Title
    • NEST - Promoting Research on Optimal Methodology and Impacts Supported by Experience
  • Funding Agency
    • European Commission
  • Date From
    • 2005
  • Date To
    • 2007
  • Title
    • Patient-specific analysis and monitoring of prosthetic implants using computational modelling
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2005
  • Date To
    • 2006
  • Title
    • The combined role of mechanics and genetics in joint morphogenesis in the developing limb, and identification of mechanosensitive genes
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • The development of an in-vitro and numerical pre-clinical testing technique to optimise the biomechanical and pharmacological characteristics of intravascular stent designs
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2005
  • Date To
    • 2007
  • Title
    • Tissue engineering of cartilage and bone in a hypoxic environment
  • Funding Agency
    • Health Research Board
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Automated patient-specific computer simulations of the biomechanical performance of medical implants
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • SmartCaP - Injectable macroporous biomaterial based on calcium phosphate cement for bone
  • Funding Agency
    • European Commission
  • Date From
    • 2004
  • Date To
    • 2008
  • Title
    • NEST-Promoting Research on Optimal Methodology and Impacts Supported by Experience
  • Funding Agency
    • Commission of the European Communities
  • Date From
    • 15/11/2005
  • Date To
    • 14/11/2007
  • Title
    • Computational analysis of the progression of the disease of osteoporosis
  • Funding Agency
    • Embark Initiative
  • Date From
    • 2004
  • Date To
    • 2007
  • Title
    • Optimization of medical implant design: application to ventilation tubes for ottis media with effusion
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2004
  • Date To
    • 2005
  • Title
    • Design of a bioreactor to induce stem cells to differentiate into specific cell phenotypes to produce cartilage/bone tissue
  • Funding Agency
    • Embark Initiative
  • Date From
    • 2003
  • Date To
    • 2006
  • Title
    • A scheme for investigating the evolution of bone remodelling laws
  • Funding Agency
    • Embark Initiative
  • Date From
    • 2003
  • Date To
    • 2006
  • Title
    • Patient-specific prosthesis analysis
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2002
  • Date To
    • 2005
  • Title
    • Trinity Centre for Bioengineering and joint programme of research with NUI, Galway
  • Funding Agency
    • Higher Education Authority - PRTLI
  • Date From
    • 2002
  • Date To
    • 2007
  • Title
    • Advanced decision support in medicine: integrating multimedia patient records with computer simulation and protocol based systems
  • Summary
    • MediLink: Prof. Jane Grimson, Principal Investigator
  • Funding Agency
    • Higher
  • Date From
    • 2000
  • Date To
    • 2003
  • Title
    • Novel bioresorbable scaffolds and culture methods for cartilage tissue engineering (SCAFCART)
  • Funding Agency
    • European Commission
  • Date From
    • 1999
  • Date To
    • 2003
  • Title
    • Mechanical integrity and architecture of bone relative to osteoporosis, ageing and drug treatment (MIAB)
  • Summary
    • Jointly obtained with Dr. Kevin O'Kelly of Dept. of Mechanical Engineering, TCD.
  • Funding Agency
    • European Commission
  • Date From
    • 1999
  • Date To
    • 2003
  • Title
    • HAS Glenoid acromion fixation prostheses
  • Funding Agency
    • Stryker-Howmedica
  • Date From
    • 2000
  • Date To
    • 2002
  • Title
    • Computer simulation for improved biofunctionality of implants for middle-ear surgery
  • Funding Agency
    • Health Research Board
  • Date From
    • 1999
  • Date To
    • 2002
  • Title
    • Biomechanical interactions in tissue engineering and surgical repair (BITES)
  • Funding Agency
    • European Commission
  • Date From
    • 1999
  • Date To
    • 2003
  • Title
    • Constitutive relationships for biomechanical modelling of vascular systems
  • Funding Agency
    • Medtronic/AVE & Enterprise Ireland
  • Date From
    • 1999
  • Date To
    • 2002

Keywords

ACCUMULATION; ACOUSTICS; ADAPTATION; ALTERED STRAIN ENVIRONMENTS; ALTERNATIVES TO ANIMAL TESTING; ANTHROPLASTY; ARTHRITIS; ARTHROPLASTIES; ARTHROPLASTY; ARTICULAR-CARTILAGE; BAYESIAN ANALYSIS; BEHAVIOR; BIMATERIAL INTERFACE; Bioengineering; BIOLOGICAL TISSUES; BIOMATERIALS; BIOMECHANICS; Biomechanics, Biomedical Engineering; Biomedical Engineering; Biomedical sciences; BIPHASIC ARTICULAR-CARTILAGE; BONE; BONE ADAPTATION; BONE CEMENT; BONE DAMAGE; BONE-CEMENT; CANCELLOUS BONE; CAT EARDRUM; CELL BIOMECHANICS; CELLS; CEMENT; CEMENT TECHNIQUE; COMPACT BONE; COMPONENTS; COMPUTER SIMULATION; CRACKS; DAMAGE; DAMAGE ACCUMULATION; DENSITY; DESIGN; EAR; Energy Release/Transport; Engineering underpinning biomedicine; EPIPHYSEAL-BASED DESIGNS; FAILURE; FATIGUE; FEMORAL STEMS; FEMUR; FINITE ELEMENT ANALYSIS; FINITE ELEMENT MODELS; FINITE ELEMENTS; FIXATION; FRACTURE FIXATION DEVICES; FRACTURE HEALING; FRACTURE MECHANICS; HAND-ACCESS PORT; HEARING; HIP PROSTHESIS; HIP REPLACEMENT; HIP-JOINT; HUMAN TEMPORAL BONES; HYDRATED SOFT-TISSUE; IMPLANT DESIGN; IMPLANT TESTING; IMPLANTS; INDUCIBLE DISPLACEMENT; INTERFACES; INTRAMEDULLARY PLUG; INTRAMEDULLARY PROSTHESES; LOOSENING; LUMBAR MOTION SEGMENT; MECHANISM; MECHANOBIOLOGY; Medical Devices; MESENCHYMAL STEM CELLS; MICROCRACKING; MICROMANUFACTURING; MICROTEXTURED; MIGRATION; MODEL; NANOBIOTECHNOLOGY; OBSTRUCTION; ORTHOPAEDICS; PRE-CLINICAL TEST; PROSTHESES; PROSTHESIS; PROSTHESIS COLLAR; PUSH-OUT TEST; REMODELLING; REPLACEMENT; STABILITY; STANDARDS; STEM; Stem Cell; STRENGTH; STRESS; STRESS-ANALYSIS; STRESSES; SUBSIDENCE; TIBIAL PLATEAU COMPONENTS; Tissue Banks, Engineering; Tissue Engineering; TOTAL HIP-ARTHROPLASTY; TOTAL HIP-REPLACEMENT; TOTAL KNEE REPLACEMENT; TOTAL SHOULDER ARTHROPLASTY

Recognition

Representations

President of the European Alliance of Medical and Biological Engineering Societies 2007

Chair, European Society of Biomechanics Workshop on Finite Element Modelling in Biomechanics and Mechanobiology 2007

External Examiner, Mechanical & Systems Engineering, University of Newcastle 2007

Examiner, Dottorato di Ricerca (VIII cycle) Scuola Interpolitecnica di Dottorato (Milano, Torino, Bari) 2006-

President, European Alliance of Medical and Biological Engineering Societies 2007

Guest Editor (with Prof. T.C. Lee) "Micro-damage in Bone", European Journal of Morphology, Vol. 42, Issue Nr. 1/2, 2005 2005

Editorial Board of the Journal of Orthopaedics and Traumatology 2004-

Editorial Board of the Journal of the Royal Society, Interface 2004-

Guest Editor with Prof. R. Contro, "Mechanics of Tissues and Implants", Meccanica Vol.35, Issue Nr. 4/5, 2002 2002

President, European Society of Biomechanics 2002-04

Director, Eblana Photonics, Trinity Enterprise Centre, Pearse St., Dublin, Ireland 2001-

Editorial board of European Cells and Materials (www.ecmjournal.org) 2000-

Chair, 12th Conference of the European Society of Biomechanics 2000

Editorial Board of the Journal of Biomechanics (2001-05 as Book Review Editor; 2005- as Surveys Editor) 1999-

President, Section of Bioengineering, Royal Academy of Medicine in Ireland 1998-00

Editorial Board of Clinical Biomechanics 1994-

Awards and Honours

Wartenweiler Memorial Lecture, International Society of Biomechanics July 2009

Elected Member of the Royal Irish Academy 17-03-2008

President Elect of European Alliance of Biomedical Engineering Societies 2006

Parsons Medal in Engineering Science, Royal Irish Academy 2003

President, European Society of Biomechanics 2002-04

Elected to Fellowship of Trinity College Dublin 1998

President, Section of Bioengineering, Royal Academy of Medicine in Ireland 1998-00

European Society of Biomechanics Research Award (S.M. Perren Award) 1996

Memberships

Member of the Institution of Engineers of Ireland 1987 – present

Member of the European Society of Biomechanics 1990 – present

Member of the American Society of Mechanical Engineers 1995 – present

Fellow of the Royal Academy of Medicine in Ireland 1995 – present

Member of the Biomedical Engineering Society (US) 2003 – present

Member of Tissue Engineering Society International 2004 – present

Founding Fellow, European Alliance of Biomedical Engineering Societies (EAMBES) 2005