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Genetics

Visiting student co-ordinator: Professor. Kevin Devine , Kevin.Devine@tcd.ie
Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE3M07 BACTERIAL GENETICS)

(05 ECTS credits) Semester 2 Basic knowledge of principles of Genetics/Biology Written exam 30 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

This module presents an evidence-based description of the basic cellular processes of transcription, translation and DNA replication in bacteria. The approach is to discuss in detail the players involved and their roles in each of the processes. The major mechanisms by which bacteria regulate expression of genetic material as well as aspects of bacterial replication and recombination will be discussed. The module covers the major events in transcription initiation, positive and negative control of transcription, coordinated control of transcription, the operon, the regulon, the stimulon, an introduction to global regulation, DNA structure and gene regulation, environmental adaptation through variations in gene expression, stereotypic and stochastic responses, and transposition - including insertion sequences IS1 and IS3 and transposons Tn3 Tn5, Tn7, Tn10 and bacteriophage Mu. Major features of the genetic code and suppression will be discussed together with mechanisms for the initiation, elongation and termination of translation. We will discuss DNA polymerases, the origin of chromosomal DNA replication (oriC) in Escherichia coli and the mechanisms by which the DNA replication is initiated and controlled. The special problems associated with replicating linear genomes and how they are surmounted will be discussed. In this context, the structure of telomeres, how they are replicated with telomerase and their association with aging will be discussed.

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE3M09 EUKARYOTIC MOLECULAR GENETICS)

(5 ECTS credits) Semester 2 Basic knowledge of principles of Genetics/Biology Written exam 30 Prof. Frank Wellmer(wellmerf@tcd.ie)

Description

This module introduces the molecular biology and genetics of eukaryotic organisms. Topics include:

  • Eukaryotic molecular and cell biology;
  • Eukaryotic gene expression;
  • Protein turnover;
  • The cell cycle;
  • Plant molecular genetics;
  • Epigenetics

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE3M11 GENOMICS)

(05 ECTS credits) Semester 1 Basic knowledge of principles of Genetics/Biology Written exam 30 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

The module will introduce core concepts in genomics, bioinformatics, and systems biology. Beginning with the sequencing of the first bacterial genome in 1995 and first draft of the human genome in 2001, our ability to determine the DNA sequences of complete genomes has revolutionized the way that genetic analysis is carried out. The result that the study of genomes is central to all modern genetics. This module provides an introduction to:

  • the methods and technologies used to sequence genomes;
  • molecular genetics techniques that can exploit genomic data to be used to study the function of genes; bioinformatics, which is the use of computers to store and analyse genomic and other large-scale molecular biological data;
  • and systems biology, which is the study of how genetic networks and whole cells work.

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE3M13 NEUROGENETICS AND DROSOPHILA)

(05 ECTS credits) Semester 2 Basic knowledge of principles of Genetics/Biology Written exam 30 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

The module will introduce the fundamentals of neuronal architecture, neuronal excitability and synaptic function, sensory systems, circadian rhythms, perception and learning and their analysis by genetic methods in model organisms (M. Ramaswami). It will introduce the genetics of neural development and behaviour, including psychiatric and cognitive genetics, and principles of nervous system evolution (K. Mitchell). These topics will also describe methods for neurogenetics in the fruitfly Drosophila melanogaster, the mouse and in humans. The module will also consider more generally the principles and logic of genetic analysis, using detailed examples from Drosophila (P. Labrador).

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE3M15 MEDICAL GENETICS)

(05 ECTS credits) Semester 2 Basic knowledge of principles of Genetics/Biology Written exam 30 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

The module introduces the genetics of human disease, from simple Mendelian traits to complex multigenic diseases and gene/drug interactions. Topics include the development of medical genetics from 1752 to the 'post-genome' era; the spectrum of human autosomal recessive diseases; RFLP analysis and the statistical evaluation of linkage data; localization and isolation of the Huntington disease gene; congenital diseases caused by chromosomal imbalance; diseases involving repeat expansions; developments and setbacks in the use of gene and molecular therapies for treatment of hereditary diseases; and pharmacogenomics (interaction of genetic background with drug response). The module also covers analysis of quantitative traits: complex human diseases such as type 2 diabetes; approaches to mapping genetic variants responsible for complex traits; heritability; genome wide association mapping.

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE3M17 EVOLUTIONARY GENETICS)

(05 ECTS credits) Semester 1 Basic knowledge of principles of Genetics/Biology Written exam 30 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

This module provides an introduction to genetic variation - its origins and its evolutionary consequences. The information in DNA is not always transmitted accurately from one generation to the next. DNA sequences can change spontaneously by the process of mutation and inaccurate DNA repair, resulting in genetic variation (polymorphism) within populations. Variable sites at different positions in the genome get shuffled into new combinations by the process of genetic recombination that occurs during sexual reproduction. Whether a particular variant (allele) survives for a long time in a population or goes extinct depends on the evolutionary forces acting on the population. If a new allele is advantageous to the population, Darwinian natural selection will tend to increase its frequency in the population; alternatively, if the new allele is disadvantageous natural selection will tend to eliminate it. However, if the population is small, random events (genetic drift) can overcome the power of natural selection.

Senior Sophister (4th Year) Modules

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4037 Transgenic Animals & Gene Therapy)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4049 Prion-like Proteins)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4051 Apoptosis)

(5 ECTS credits) Semester 2 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4276 Stem Cell Biology)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4057 Plant Development Genetics)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4061 Genetics and Immunology of Neural Diseases)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4025 Molecular Evolution II)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4029 Microbial Molecular Genetics)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4031 Plant Molecular Genetics II)

(5 ECTS credits) Semester 2 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4032 Developmental Genetics of Drosophila)

(5 ECTS credits) Semester 2 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4034 Human Evolutionary Genetics)

(5 ECTS credits) Semester 1 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4053 Genetics of Neural Development)

(5 ECTS credits) Semester 2 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4054 Behavioural Genetics)

(5 ECTS credits) Semester 2 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

(GE4055 Epigenetics)

(5 ECTS credits) Semester 2 Prof. Frank Wellmer (wellmerf@tcd.ie)

Description

TBC