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Biochemistry - Junior Sophister (3rd Year) Modules - Full Academic Year

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3110 - Protein Structure

10 ECT Credits MT NA 100% by examination 30 hours Derek Nolan

Description

This module introduces the concept of proteins as molecular nanomachines that act as the workhorses in living cells. The relationship between protein structure and function and how drugs can be exploited to target proteins to treat diseases will also be covered. Topics covered in this module will include functional group chemistry and reaction mechanisms, protein structure and function as well as enzyme behaviour, kinetics, reaction mechanisms and regulation.

THIS MODULE IS LECTURE ONLY

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3140 - Biochemistry in health and disease

10 ECT Credits HT NA 100% by examination 21 hours Derek Nolan

Description

This module will cover aspects of biochemistry that are relevant in pathological, infectious and diseased states. The module will introduce: metabolism relevant to diabetes, cancer and immune cell function, components of the innate immune system and describe how they function to eliminate pathogen, the mechanism of enzyme inhibitors and propose how this can be exploited for drug therapy and the processes of drug target identification, validation and development.

THIS MODULE IS LECTURE ONLY

NOTE: BI3935 cannot be taken together with either BI3915 or BI3925 in MT. Otherwise all other combinations are fine.

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3115 - Biochemical Analysis

5 ECT Credits MT NA 100% coursework & continuous assessment TBC Derek Nolan

Description

This module will provide instruction in basic biochemistry laboratory skills with a focus on preparation of solutions and the use of dilutions etc. (Molarity exercise & buffers) and also how to keep a laboratory note book. The latter will be assessed by a mid-term inspection of your laboratory note book. There will also be a series of lectures on data handling (statistics) and a project relating to the material covered in these lectures.

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3120 - Membrane & Cell Biology

10 ECT Credits MT NA 30% coursework & 70% by examination Lectures: 32 hours Practicals: 25 hours Derek Nolan

Description

This module covers the structure and function of biological membranes, the cytoskeleton, related signal transduction pathways and associated pathological conditions important in human health. Topics will include: the structure, function and organization of biological membranes as well as describing the bioenergetic and transport processes that occur across them. The module will also introduce the tubulin, intermediate and actin based cytoskeleton and will cover some aspects of vesicle traffic in cells. Some basic cell signalling pathways will also be covered.
As well as lectures the module includes a set of linked practical sessions. These sessions will include (i) ion transport, thin layer chromatography, (ii) use of radioisotopes in research, assay of a phosphodiesterase and cAMP binding studies, (iii) use and application of tissue culture techniques.

On successful completion of this Module, students should be able to:

  • Membrane structure
  • Describe the chemistry and biochemistry of the major lipid classes.
  • Demonstrate an understanding of lipid metabolism and how it relates to human diseases
  • Recall and integrate key knowledge and concepts concerning the role of lipids in membrane structure and function.
  • Demonstrate how physical chemical principles contribute to our understanding of how lipid structure relates to lipid function.
  • Explain what lipidomics is all about.
  • Describe the evidence for and methods used to determine the asymmetric distribution of membrane proteins within the bilayer structure.
  • Describe the factors that determine the mobility of membrane proteins and explain the role their mobility has in signal and energy transduction
  • Demonstrate knowledge of the biosynthesis of membrane proteins and the mechanisms of insertion and transport to their various final locations.
  • Compare and contrast the structure of prokaryotic and eukaryotic membrane transporters; explain the various mechanisms of membrane transport, the procedures for assaying membrane transport and describe the way membrane potentials and ion gradients are generated and used physiologically.
  • Describe the structure and function of tubulin, the two microtubular motors and the major microtubular accessory proteins.
  • Explain the mechanism and regulation of the assembly and disassembly of microtubules and the role of microtubule organizing centers and nucleotides.
  • Explain the mechanism of both anterograde and retrograde cytoplasmic streaming.
  • Discuss the tubulin gene families and the regulation of their expression.
  • Describe the polymerisation, structure, function and biomedical relevance of Intermediate Filaments.
  • Describe the structure and function of the actin cytoskeleton in non-muscle cells.
  • Explain how the assembly and disassembly of actin filaments is regulated. 
  • Compare and contrast the actin nucleation machinery in eukaryotes.         
  • Describe molecular basis for conformational switch of small GTPases, such as Rab and Arf and the role of small GTPases in the formation, transport and docking of vesicles in eukaryotes.
  • Describe the signalling mechanisms activated downstream of G protein coupled receptors and receptor tyrosine kinases
  • Describe the molecular basis underlying transcriptional regulation by steroid hormones and their cognate receptors
Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3010 - Nucleic Acids

10 ECT Credits HT NA 30% coursework & 70% by examination Lectures: 33 hours Practicals: 23.5 hours Derek Nolan

Description

This module covers the structure and function of nucleic acids and the molecular basis of gene regulation including DNA replication and repair, transcription and translation.. As well as lectures the module includes a set of linked practical sessions which will involve two mini projects: (i) characterising a recombinant plasmid and (ii) expressing recombinant RAS.

On successful completion of this module students will be able to:

  • Recall and integrate key knowledge and concepts about DNA structure and function and process and assess the importance of DNA replication and DNA repair
  • Describe the molecular and structural features of transcription initiation, transfer RNA charging and ribosomal translation
  • Recognize the functional groups of nucleic acids and relate how the chemistry is linked to biological function
  • Recall and integrate key knowledge and concepts about how gene expression is regulated and demonstrate an understanding of the processes and importance of transcription and translation
  • Relate the theory behind techniques used in recombinant DNA technology and evaluate how these techniques can be applied to biological problems
Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3140 - Biochemistry in health and disease

10 ECT Credits HT NA 30% coursework & 70% by examination Lectures: 33 hours Practicals: 31 hours Derek Nolan

Description

This module will cover aspects of biochemistry that are relevant in pathological, infectious and diseased states. The module will introduce: metabolism relevant to diabetes, cancer and immune cell function, components of the innate immune system and describe how they function to eliminate pathogen, the mechanism of enzyme inhibitors and propose how this can be exploited for drug therapy and the processes of drug target identification, validation and development. The module includes a set of linked practical sessions covering: (i) RAS and cancer and (ii) culture and differentiation of a medically important protozoan parasite.

On successful completion of this module students will be able to:

  • Explain the relationship between carbohydrate, fatty acid and amino acid metabolism and the metabolic changes that occur in response to starvation, exercise and diabetes.
  • Define how metabolism is relevant to diabetes, cancer and immune cell function.
  • Identify cells, receptors and soluble components of the innate immune system and how they function to eliminate pathogen
  • Define how an adaptive immune response is initiated and how different types of adaptive immune responses are used to eliminate particular pathogens
  • Demonstrate an understanding of the mechanism of enzyme inhibitors and propose how this can be exploited for drug therapy
  • Appraise the processes of drug target identification, validation and development
  • Explain the process of computation drug design and its relevance to translational science 
Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3020 -Research Skills

10 ECT Credits HT NA 80% coursework & 20% by examination Varies Derek Nolan

Description

The purpose of this module is to develop research, critical analysis and communication skills that are essential for a graduate biochemist. Students will undertake a major written review of a subject area of biochemical relevance under the supervision of a member of staff of the school. The topic for this review will given to the student in the first week of the first semester with the review to be submitted at the beginning of the second semester. There will also be a tutorial session on the use of Endnote for referencing within the context of the minireview. In addition the student will prepare and present a short oral summary of their review. Critical analysis of primary data is a key skill and this addressed through a series of 4 separate quantitative problem sessions in the second semester. Each problem subject will involve three session: (i) introduction and training in problem solving, students will given a similar problem which they will answer as homework, (ii) there will be a solution session for this problem, and a final session will involve another version of the problem which students will solve under exam conditions and which counts towards the Module mark.

Immunology - Junior Sophister (3rd Year) Modules - Full Academic Year

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3210 - Biochemistry

10 ECT Credits HT NA

Description

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3215 - Analytical skills

5 ECT Credits MT NA

Description

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3220 - Core Concepts in Immunology

10 ECT Credits MT NA

Description

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3230 - Gene Regulation

10 ECT Credits HT NA

Description

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3240 - Microbiology & Immunology

10 ECT Credits HT NA

Description

Module Code & Name ECTs credits Duration and semester Prerequisite Subjects Assessment Contact Hours Contact Details

BI3020 - Research Skills

10 ECT Credits HT NA

Description