Selected Publications:

Lee B, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB. (2024). The influence of flocculation upon global gene transcription in a yeast CYC8 mutant. Microb Genom. Mar; 10(3):001216. doi: 10.1099/mgen.0.001216. PMID: 38529898 

Alves de Castro P, Figueiredo Pinzan C, Dos Reis TF, Valero C, Van Rhijn N, Menegatti C, de Freitas Migliorini IL, Bromley M, Fleming AB, Traynor AM, Sarikaya-Bayram Ö, Bayram Ö, Malavazi I, Ebel F, Barbosa JCJ, Fill T, Pupo MT, Goldman GH. (2024). Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection. Nat Commun. Jan 2;15(1):33. doi: 10.1038/s41467-023-44329-1. PMID: 38167253

Karahoda B, Pfannenstiel BT, Sarikaya-Bayram Ö, Dong Z, Ho Wong K, Fleming AB, Keller NP, Bayram Ö. (2023). The KdmB-EcoA-RpdA-SntB (KERS) chromatin regulatory complex controls development, secondary metabolism and pathogenicity in Aspergillus flavus. Fungal Genet Biol. 2023 Dec;169:103836. doi: 10.1016/j.fgb.2023.103836. PMID: 37666447 

Lee B, Church M, Hokamp K, Alhussain MM, Bamagoos AA, Fleming AB. (2023). Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex. PLoS Genet. Aug 11;19(8):e1010876. doi: 10.1371/journal.pgen.1010876. PMID: 37566621.

Karahoda B, Pardeshi L, Ulas M, Dong Z, Shirgaonkar N, Guo S, Wang F, Tan K, Sarikaya-Bayram Ö, Bauer I, Dowling P, Fleming AB, Pfannenstiel BT, Luciano-Rosario D, Berger H, Graessle S, Alhussain MM, Strauss J, Keller NP, Wong KH, Bayram Ö. (2022). ‘The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis’. Nucleic Acids Res. Sep 23;50(17):9797-9813.

Silva LP, Frawley D, Assis LJ, Tierney C, Fleming AB, Bayram O, Goldman GH. (2020).  'Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources.', mSphere, 5, 5 (2020), 1-14

Frawley D, Stroe MC, Oakley BR, Heinekamp T, Straßburger M, Fleming AB, Brakhage AA, Bayram Ö. (2020). 'The Pheromone Module SteC-MkkB-MpkB-SteD-HamE Regulates Development, Stress Responses and Secondary Metabolism in Aspergillus fumigatus.', Frontiers in Microbiology, 11, 811, 10.3389/fmicb.2020.00811.

Frawley D, Greco C, Oakley B, Alhussain MM, Fleming AB, Keller NP, Bayram Ö. (2020). 'The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus.', Cellular Microbiology, 22, 6 (2020), 1-14

Kröger C, Schauer K, Clerkin S, Maertlbauer E and Fleming AB*. (2019). 'Draft Genome Sequence and Annotation of Acinetobacter junii MHI21018, Isolated from Bovine Colostrum', Microbiology Resource Announcements (2019).

Church MC and Fleming AB. (2017). A role for histone acetylation in regulating transcription elongation. Transcription. 2017 Dec 8:1-8. doi: 10.1080/21541264.2017.1394423. PMID:29219750

Young CPᵻ, Hillyer C, Hokamp Kᵻ, Fitzpatrick DJ, Konstantinov NK, Welty JS, Ness SA, Werner-Washburne M, Fleming ABᵻ*, Osley MAᵻ*. (2017). Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast. BMC Genomics. Jan 26;18(1):107. doi: 10.1186/s12864-017-3509-9.

Church M, Smith KC, Alhussain MM, Pennings S, Fleming AB. (2017). Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene. Nucleic Acids Res. Jan 23. pii: gkx028. doi: 10.1093/nar/gkx028.

Haran J, Boyle H, Hokamp K, Yeomans T, Liu Z, Church M, Fleming AB , Anderson MZ, Berman J, Myers LC, Sullivan DJ, Moran GP. ( 2014 ). Telomeric ORFs (TLOs) in Candida spp. Encode Mediator Subunits That Regulate Distinct Virulence Traits. PLoS Genet . Oct 30;10(10):e1004658.

Fleming, AB, Beggs S, Church M, Tsukihashi Y, Pennings S. ( 2014 ). The yeast Cyc8-Tup1 complex cooperates with Hda1p and Rpd3p histone deacetylases to robustly repress transcription of the subtelomeric FLO1 gene. Biochim Biophys Acta . GRM, Nov; 1839(11):1242-55.

Shieh GS, Pan CH, Wu JH, Sun YJ, Wang CC, Hsiao WC, Lin CY, Tung L, Chang TH, Fleming AB , Hillyer C, Lo YC, Berger SL, Osley MA, Kao CF. ( 2011 ). H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast. BMC Genomics ., Dec 22;12:627.

Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A.B., et al., ( 2010 ). Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol., 17, 629-634

Fleming, A.B ., Kao, C.K., Hillier, C., Pickaart, M. and Osley, M. A. ( 2008 ). H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. Mol Cell ., 31 , 57-66 .

Fleming, A.B . and Pennings, S. ( 2007 ). Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene. Nucleic Acids Res ., 35 , 5520-31 .

Osley, MA, Fleming, AB , and Kao, CK. ( 2006 ). Histone ubiquitylation and the regulation of transcription, in “Chromatin Dynamics in Cellular Function”, Springer Verlag, Results Probl Cell Differ . , 41, 47-75.

Tsukuda, T., Fleming, A.B ., Nickoloff, J.A. and Osley, M.A. ( 2005 ). Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae . Nature . 438, 379-383.

Fleming, A.B . and Osley, M.A. (2004) . Silence of the Rings. Cell . 119, 449-451.

Fleming, A.B . and Pennings, S. (2001) . Antagonistic remodelling by Swi-Snf and Tup1-Ssn6 of an extensive chromatin region forms the background for FLO1 gene regulation. EMBO J . 18, 5219-5231.