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Professor Jeffrey O'Sullivan
Assistant Professor in Biological Sciene, Dental Science
Assistant Professor in Biological Sciene, Sch Office - Biochemistry & Immunology


Publications and Further Research Outputs

Peer-Reviewed Publications

O'Grady I, O'Sullivan J., Alcohol consumption modulates Candida albicans-induced oral carcinogenesis and progression., Journal of oral biosciences, 2023, pS1349-0079(23)00130-5 Journal Article, 2023 DOI TARA - Full Text

Anderson A, O'Sullivan J., The two faces of autophagy in oral squamous cell carcinoma, Archives of Oral Biology, 2022 Journal Article, 2022 DOI

Magnano S, Hannon Barroeta P, Duffy R, O'Sullivan J, Zisterer DM., Cisplatin induces autophagy-associated apoptosis in human oral squamous cell carcinoma (OSCC) mediated in part through reactive oxygen species., Toxicology and applied pharmacology, 427, 2021, p115646 Journal Article, 2021 DOI

Ahmed WH, Boulet N, Briot A, Ryan BJ, Kinsella GK, O'Sullivan J, Les F, Mercader-Barceló J, Henehan GTM, Carpéné C., Novel Facet of an Old Dietary Molecule? Direct Influence of Caffeine on Glucose and Biogenic Amine Handling by Human Adipocytes., Molecules (Basel, Switzerland), 26, (13), 2021 Journal Article, 2021 DOI

Sinevici N, Harte N, O'Grady I, Xie Y, Min S, Hun Mok K, O'Sullivan J., The novel therapeutic potential of bovine "-lactalbumin made lethal to tumour cells and oleic acid in oral squamous cell carcinoma., European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2020 Journal Article, 2020 DOI

Haj Ahmed W, Peiro C, Fontaine J, Ryan BJ, Kinsella GK, O'Sullivan J, Grolleau JL, Henehan GTM, Carpéné C., Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue., Medicines (Basel), 7, (4), 2020 Journal Article, 2020 DOI

Ibrahim O, O'Sullivan J., Iron chelators in cancer therapy., Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 33, (4-5), 2020, p201-215 Journal Article, 2020 DOI

O'Grady I, Anderson A, O'Sullivan J., The interplay of the oral microbiome and alcohol consumption in oral squamous cell carcinomas., Oral oncology, 110, 2020, p105011 Journal Article, 2020 DOI

Bennett JH, Beeley JA, Anderson P, Belfield L, Brand HS, Didilescu AC, Dymock D, Guven Y, Hector MP, Holbrook P, Jayasinghe JAP, O'Sullivan J, Riggio M, Roger-Leroi V, Scheven B, Sloan AJ, Vandamme K, Manzanares MC., A core curriculum in the biological and biomedical sciences for dentistry., European journal of dental education : official journal of the Association for Dental Education in Europe, 24, (3), 2020, p433-441 Journal Article, 2020 DOI

A. Prasanth Saraswati, Nicola Relitti, Margherita Brindisi, Jeremy D. Osko, Giulia Chemi, Stefano Federico, Alessandro Grillo, Simone Brogi, Niamh H. McCabe, Richard C. Turkington, Ola Ibrahim, Jeffrey O'Sullivan, Stefania Lamponi, Magda Ghanim, Vincent P. Kelly, Daniela Zisterer, Rebecca Amet, Patricia Hannon, Francesca Vanni, Cristina Ulivieri, Daniel Herp, Federica Sarno, Antonella Di Costanzo, Fulvio Saccoccia, Giovina Ruberti, Manfred Jung, Lucia Altucci, Sandra Gemma, Stefania Butini, David W. Christianson, and Giuseppe Campiani, Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, 2 Synthesis, Structural Analysis, and Biological Evaluation , ACS Medicinal Chemistry Letters, 2020 Journal Article, 2020 DOI TARA - Full Text

Carvalho LFCS, Dos Santos L, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto LPM, Martin AA, Lyng FM, Byrne HJ., Can ethanol affect the cell structure? A dynamic molecular and Raman spectroscopy study., Photodiagnosis and photodynamic therapy, 30, 2020, p101675 Journal Article, 2020 DOI

Sinevici N, Mittermayer S, Davey GP, Bones J, O'Sullivan J, Salivary N-glycosyalation as a biomarker of Oral Cancer: A pilot study., Glycobiology, 2019 Journal Article, 2019 DOI

Shanahan, P. and O'Sullivan, J. and Tipton, K.F. and Kinsella, G.K. and Ryan, B.J. and Henehan, G.T.M., Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase, Journal of Food Biochemistry, 2019, pe12697- Journal Article, 2019 DOI

Margherita Brindisi, Cristina Ulivieri, Gloria Alfano, Sandra Gemma,Francisco de Asís Balaguer, Tuhina Khan, Alessandro Grillo, Giulia Chemi, Grégory Menchon, Andrea E. Prota, Natacha Olieric, Daniel Lucena-Agell, Isabel Barasoain, J. Fernando Diaz, Angela Nebbioso, Maria Rosaria Conte, Ludovica Lopresti, Stefania Magnano, Rebecca Amet, Paula Kinsella, Daniela M. Zisterer, Ola Ibrahim, Jeff O'Sullivan, Lucia Morbidelli, Roberta Spaccapelo, Cosima Baldari, Stefania Butini, Ettore Novellino, Giuseppe Campiani, Lucia Altucci, Michel Steinmetz, Simone Brogi, Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, European Journal of Medicinal Chemistry, 2019, p290-320 Journal Article, 2019 URL TARA - Full Text DOI

Carvalho LFCS, Bonnier F, Tellez C, Dos Santos L, O'Callaghan K, O'Sullivan J, Soares LES, Flint S, Martin AA, Lyng FM, Byrne HJ., Raman spectroscopic analysis of oral cells in the high wavenumber region., Experimental and molecular pathology, 103, (3), 2017, p255-262 Journal Article, 2017 DOI

Al Ghazal L, O'Sullivan J, Claffey N, Polyzois I, Comparison of two different techniques used for the maintenance ofperi-implant soft tissue health: a pilot randomized clinical trial., Acta Odontologica Scandinavica , 75, (7), 2017, p542-549 Journal Article, 2017 DOI

Sinevici N, O'sullivan J, Oral cancer: Deregulated molecular events and their use as biomarkers, Oral Oncology, 61, 2016, p12 - 18 Journal Article, 2016 URL DOI

Carvalho LF, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Byrne HJ, Lyng FM, Raman micro-spectroscopy for rapid screening of oral squamous cell carcinoma., Experimental and molecular pathology, 98, (3), 2015, p502-9 Journal Article, 2015 DOI

Carvalho L.F.C.S, Bonnier F, O'Callaghan K, O'Sullivan J, Flint S, Neto L.P.M, Soto C.A.T, Dos Santos L, Martin A.A, Byrne H.J, Lyng F.M, Raman spectroscopic analysis of oral squamous cell carcinoma and oral dysplasia in the high-wavenumber region, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2015, 9531, 2015 Conference Paper, 2015 URL DOI

O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54 Journal Article, 2015 DOI TARA - Full Text

Olivieri A, Tipton K, O'Sullivan J, Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine., Biochimica et biophysica acta, 1820, (4), 2012, p482-487 Journal Article, 2012 DOI

Olivieri A, Rico D, Khiari Z, Henehan G, O'Sullivan J, Tipton K, From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase., Journal of neural transmission (Vienna, Austria : 1996), 118, (7), 2011, p1079-1089 Journal Article, 2011 DOI

Aldo Olivieri, Jeff O'Sullivan, Luis Raimon Alvarez Fortuny, Itziar Larrauri Vives, Keith F. Tipton, Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions, BBA - Proteins and Proteomics, 1804, (4), 2010, p941-947 Journal Article, 2010 TARA - Full Text

Olivieri A, O'Sullivan J, Fortuny LR, Vives IL, Tipton KF, Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions., Biochimica et biophysica acta, 1804, 2010, p941 - 947 Journal Article, 2010 DOI

Olivieri A, Davey G, O'Sullivan M I, Tipton K F, Boyce S, McDonald A G, O'Sullivan J(ed.), European Conference on Chemistry for Life Sciences, Poland, 2007, 2008, 51-57 p Proceedings of a Conference, 2008

Copper amine oxidases: structures, catalytic mechanisms and role in pathophysiology in, editor(s)Giovanni Floris Bruno Mondovi , Nomenclature and Potential Functions of the Mammalian Copper Amine Oxidases, London, Taylor & Francis Group, 2008, [Boyce S, Tipton KF, O'Sullivan M I, Davey G P, Motherway Gildea M, McDonald A G, Olivieri A, O'Sullivan J] Book Chapter, 2008

Andrew McDonald, Keith Tipton, Jeff O'Sullivan, Aldo Olivieri, Gavin Davey, Anne-marie Coonan and Wenhao Fu, Modelling the roles of MAO and SSAO in glucose transport, Journal of Neural Transmission, 114, (6), 2007, p783 - 786 Journal Article, 2007

Aldo Olivieri, Keith Tipton and Jeff O'Sullivan, L-Lysine as a recognition molecule for the VAP-1 function of SSAO, Journal of Neural Transmission, 6, (114), 2007, p747 - 749 Journal Article, 2007

Jeff O'Sullivan, Gavin Davey, Michael O'Sullivan and Keith F. Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, Journal of Neural Transmission, 6, (114), 2007, p751 - 756 Journal Article, 2007

O'Sullivan, J., O'Sullivan, M. I., Tipton, K.F., Davey, G., Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine, Journal of Neural Transmission, Suppl, (71), 2007, p105 - 112 Journal Article, 2007

O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF., Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do., Neurotoxicology, Jan 25, (1-2), 2004, p303 - 315 Journal Article, 2004

Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J, Monoamine oxidases: Certainties and uncertainties, Current Medicinal Chemistry, Aug 11, (15), 2004, p1965 - 1982 Journal Article, 2004

Monoamine oxidase (MAO):functions in the central nervous system in, editor(s)George Adelman And Barry H. Smith. , Encylopedia of Neuroscience 2004 , Elsevier, 2004, [Tipton KF, O'Sullivan J. Youdim MBH] Book Chapter, 2004

Tipton KF, O'Sullivan M, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme., Biochemical Society Transactions, Jun:31, (Pt. 3), 2003, p711 - 715 Journal Article, 2003

O'Sullivan J, O'Sullivan M, Tipton K F, Unzeta M, Hernandez M, Davey G, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses. , Biochemica et biophysica acta, Apr 11, (1647), 2003, p367 - 371 Journal Article, 2003

Non-Peer-Reviewed Publications

Magnano, S., O'Sullivan, J. and Zisterer, D.M., Pre-clinical evaluation of targeting autophagy for the treatment of Oral Squamous Cell Carcinoma , IADR Irish Divison, Belfast, November 2nd 2017, 2017 Poster, 2017

Research Expertise


Oral Cancer; Oral inflammation; Amine Oxidases, Protein Science


  • Title
    • The development of in-vitro models of alcohol induced oral carcinogenesis
  • Funding Agency
    • Dublin Dental University Hospital/ Trinity College Dublin
  • Date From
    • Oct 2010
  • Title
    • Cloning and charaterisation of dental pulp SSAO
  • Title
    • The role of dental pulp stem cells in neurotrophic support
  • Title
    • The influence of Periodontitis in Diabetes


Biochemistry; Biochemistry, metabolism; Biochemistry, Nucleic Acid; Biochemistry, Proteins; Biological Modeling; Biological Sciences; Cell and tissue development; Cell Communication; Cellular Biology; Dental education; Developmental neurobiology; Enzymes Catalysis; Enzymology and catalysis; Immune system; Immunology, Immunotherapy; Mathematical modelling; Molecular Biology; Neurodegeneration; Neuroscience; Peridontology; Protein chemistry, structure and folding; Proteins, enzymology and protein engineering; Proteomes, proteomics; Systematic Biology; Tissue Culture



Irish Division IADR Council Member President 2018-19 2012

ASEiD Council Member 2011

Awards and Honours

Irish Society of Toxicology Scholarship 2001


European Association for Cancer Research 2011

Biochemistry Society 2000

International Association of Dental Research 2006

Association of Basic Science Teachers in Dentistry 2008

Institute of Physics (IoP) Sept 2017