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Daniel J Kelly
Professor, Mechanical & Manuf. Eng

Biography

Dr Daniel Kelly is the Professor of Tissue Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering (TCBE). He is also one of the founding Principal Investigators of the Advanced Materials and Bioengineering Research (AMBER) centre based in Trinity College Dublin. Prof Kelly is a current or past recipient of a Science Foundation Ireland President of Ireland Young Researcher Award, a Fulbright Visiting Scholar grant (at the Department of Biomedical Engineering in Columbia University, New York) and three European Research Council awards (Starter grant 2010; Consolidator grant 2015; Proof of Concept grant 2017). His research focuses on developing novel tissue engineering and 3D bioprinting strategies to regenerate damaged and diseased musculoskeletal tissues. To date he has published over 130 articles in peer-reviewed journals.

Publications and Further Research Outputs

Peer-Reviewed Publications

Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436 Journal Article, 2017

Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 Journal Article, 2017

Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 2017 Journal Article, 2017

Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 2017 Journal Article, 2017

Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 2017 Journal Article, 2017

Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 2017 Journal Article, 2017

Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436 Journal Article, 2017

Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436 Journal Article, 2017

Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 2017 Journal Article, 2017

Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691 Journal Article, 2017

Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 2017 Journal Article, 2017

Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 Journal Article, 2017

Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691 Journal Article, 2017

Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 Journal Article, 2017

Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436 Journal Article, 2017

Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764 Journal Article, 2017

Dikina, A.D., Almeida, H.V., Cao, M., Kelly, D.J., Alsberg, E., Scaffolds Derived from ECM Produced by Chondrogenically Induced Human MSC Condensates Support Human MSC Chondrogenesis, ACS Biomaterials Science and Engineering, 3, (7), 2017, p1426-1436 Journal Article, 2017

Harris, E., Liu, Y., Cunniffe, G., Morrissey, D., Carroll, S., Mulhall, K., Kelly, D.J., Biofabrication of soft tissue templates for engineering the bone-ligament interface, Biotechnology and Bioengineering, 2017 Journal Article, 2017

Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 2017 Journal Article, 2017

Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764 Journal Article, 2017

Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 2017 Journal Article, 2017

Henrique V. Almeida, Anna D. Dikina, Kevin J. Mulhall, Fergal J. O"Brien, Eben Alsberg, Daniel J. Kelly, Porous Scaffolds Derived from Devitalized Tissue Engineered Cartilaginous Matrix Support Chondrogenesis of Adult Stem Cells, ACS Biomaterials Science & Engineering, 2017 Journal Article, 2017

Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691 Journal Article, 2017

Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691 Journal Article, 2017

Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 Journal Article, 2017

Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764 Journal Article, 2017

Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764 Journal Article, 2017

Gonzalez-Fernandez, T., Sathy, B.N., Hobbs, C., Cunniffe, G.M., McCarthy, H.O., Dunne, N.J., Nicolosi, V., O'Brien, F.J., Kelly, D.J., Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector, Acta Biomaterialia, 55, 2017, p226-238 Journal Article, 2017

Sathy, B.N., Olvera, D., Gonzalez-Fernandez, T., Cunniffe, G.M., Pentlavalli, S., Chambers, P., Jeon, O., Alsberg, E., McCarthy, H.O., Dunne, N., Haut Donahue, T.L., Kelly, D.J., RALA complexed "-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo, Journal of Materials Chemistry B, 5, (9), 2017, p1753-1764 Journal Article, 2017

Pentlavalli, S., Chambers, P., Sathy, B.N., O'Doherty, M., Chalanqui, M., Kelly, D.J., Haut-Donahue, T., Mccarthy, H.O., Dunne, N.J., Simple Radical Polymerization of Poly(Alginate-Graft-N-Isopropylacrylamide) Injectable Thermoresponsive Hydrogel with the Potential for Localized and Sustained Delivery of Stem Cells and Bioactive Molecules, Macromolecular Bioscience, 2017 Journal Article, 2017

Rodenas-Rochina, J., Kelly, D.J., Gómez Ribelles, J.L., Lebourg, M., Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds, Journal of Biomedical Materials Research - Part A, 105, (6), 2017, p1684-1691 Journal Article, 2017

Rodenas-Rochina, J., Kelly, D.J., Gomez Ribelles, J., Lebourg, M. , Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells, Biomedical Physics & Engineering Express , 2, 2016, p035005 Journal Article, 2016 DOI

Almeida, H.V., Mulhall, K.J., O'Brien, F.J., Kelly, D.J., Stem cells display a donor dependent response to escalating levels of growth factor release from extracellular matrix-derived scaffolds, Journal of Tissue Engineering and Regenerative Medicine, 2016, p1-9- Journal Article, 2016 DOI

Steward, A.J., Kelly, D.J., Wagner, D.R., Purinergic Signaling Regulates the Transforming Growth Factor-ß3-Induced Chondrogenic Response of Mesenchymal Stem Cells to Hydrostatic Pressure, Tissue Engineering - Part A, 22, (11-12), 2016, p831-839 Journal Article, 2016 DOI

Pauly, H.M., Kelly, D.J., Popat, K.C., Trujillo, N.A., Dunne, N.J., McCarthy, H.O., Haut Donahue, T.L., Mechanical properties and cellular response of novel electrospun nanofibers for ligament tissue engineering: Effects of orientation and geometry, Journal of the Mechanical Behavior of Biomedical Materials, 61, 2016, p258-270 Journal Article, 2016 DOI

Saha, A., Rolfe, R., Carroll, S., Kelly, D.J., Murphy, P., Chondrogenesis of embryonic limb bud cells in micromass culture progresses rapidly to hypertrophy and is modulated by hydrostatic pressure, Cell and Tissue Research, 2016, p1-13 Journal Article, 2016 DOI

OReilly, A., Hankenson, K.D., Kelly, D.J., A computational model to explore the role of angiogenic impairment on endochondral ossification during fracture healing, Biomechanics and Modeling in Mechanobiology, 15, 2016, p1279-1294 Journal Article, 2016 DOI

Luo, L., O'Reilly, A.R., Thorpe, S.D., Buckley, C.T., Kelly, D.J., Engineering zonal cartilaginous tissue by modulating oxygen levels and mechanical cues through the depth of infrapatellar fat pad stem cell laden hydrogels, Journal of Tissue Engineering and Regenerative Medicine, 2016 Journal Article, 2016 DOI

Mesallati T., Buckley C.T. and Kelly D.J. , Engineering cartilaginous grafts using chondrocyte-laden hydrogels supported by a superficial layer of stem cells, Journal of Tissue Engineering and Regenerative Medicine , 5, (18), 2016, p2353-2362 Journal Article, 2016 DOI

Daly A.C, Cunniffe G.M, Sathy B.N, Jeon O, Alsberg E, Kelly D.J, 3D Bioprinting: 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering (Adv. Healthcare Mater. 18/2016), Advanced Healthcare Materials, 5, (18), 2016, p2352- Journal Article, 2016 DOI URL

O'Reilly, A., Kelly, D.J, The role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects., Journal of Orthopaedic Research , 34, (6), 2016, p1026-36 Journal Article, 2016 DOI

Daly, A.C., Critchley, S.E., Rencsok, E.M., Kelly, D.J., A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage, Biofabrication, 8, (4), 2016, p045002- Journal Article, 2016 DOI

Verrier, S., Alini, M., Alsberg, E., Buchman, S.R., Kelly, D., Laschke, M.W., Menger, M.D., Murphy, W.L., Stegemann, J.P., Schütz, M., Miclau, T., Stoddart, M.J., Evans, C., Tissue engineering and regenerative approaches to improving the healing of large bone defects, European Cells and Materials, 32, 2016, p87-110 Journal Article, 2016 TARA - Full Text URL

Thompson, E.M., Matsiko, A., Kelly, D.J., Gleeson, J.P., O'Brien, F.J., An Endochondral Ossification-Based Approach to Bone Repair: Chondrogenically Primed Mesenchymal Stem Cell-Laden Scaffolds Support Greater Repair of Critical-Sized Cranial Defects Than Osteogenically Stimulated Constructs in Vivo, Tissue Engineering - Part A, 22, (5-6), 2016, p556-567 Journal Article, 2016 DOI

Burke D, Kelly D.J, A mechanobiological model of endothelial cell migration and proliferation, Computer Methods in Biomechanics and Biomedical Engineering, 19, (1), 2016, p74 - 83 Journal Article, 2016 DOI URL

Daly, A.C., Cunniffe, G.M., Sathy, B.N., Jeon, O., Alsberg, E., Kelly, D.J., 3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering, Advanced Healthcare Materials, 2016 Journal Article, 2016 DOI

Lu, L., Chu, J., Rajalakshmanan, E., Mulhall, K., Kelly, D. J., Engineering tissues that mimic the zonal nature of articular cartilage using decellularized cartilage explants seeded with adult stem cells., ACS Biomaterials Science & Engineering , 2016 Journal Article, 2016 DOI

Almeida, H.V., Eswaramoorthy, R., Cunniffe, G.M., Buckley, C.T., O'Brien, F.J., Kelly, D.J., Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration, Acta Biomaterialia, 36, 2016, p55-62 Journal Article, 2016 DOI

Gonzalez-Fernandez, T., Tierney, E.G., Cunniffe, G.M., O'Brien, F.J., Kelly, D.J., Gene Delivery of TGF-ß3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering, Tissue Engineering - Part A, 22, (9-10), 2016, p776-787 Journal Article, 2016 DOI

O'Reilly, A., Kelly, D.J., Unravelling the Role of Mechanical Stimuli in Regulating Cell Fate During Osteochondral Defect Repair, Annals of Biomedical Engineering, 44, (2), 2016, 3446-3459 Journal Article, 2016 DOI

Steward AJ, Kelly DJ, Mechanical regulation of mesenchymal stem cell differentiation., Journal of anatomy, 227, (6), 2015, 717-731 Journal Article, 2015 DOI

Gannon, A.R., Nagel, T., Bell, A.P., Avery, N.C., Kelly, D.J., The changing role of the superficial region in determining the dynamic compressive properties of articular cartilage during postnatal development, Osteoarthritis and Cartilage, 23, (6), 2015, p975-984 Journal Article, 2015 DOI

Mesallati T, Sheehy E.J, Vinardell T, Buckley C.T, Kelly D.J, Tissue engineering scaled-up, anatomically shaped osteochondral constructs for joint resurfacing, European Cells and Materials, 30, 2015, p163 - 186 Journal Article, 2015 URL URL TARA - Full Text

Luo L., Thorpe S.D., Buckley C.T. and Kelly D.J. , The effects of dynamic compression on the development of cartilage grafts engineered using bone marrow and infrapatellar fat pad derived stem cells, Biomedical Materials, 21, (10(5)), 2015, p055011 Journal Article, 2015 DOI

Almeida, A.V, Cunniffe, G.M., Vinardell, T., Buckley, C.T., O'Brien, F.J., Kelly, D.J. , Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis. , Advanced Healthcare Materials, 4, (7), 2015, 1043-1053 Journal Article, 2015 DOI

Almeida H.V, Cunniffe G.M, Vinardell T, Buckley C.T, O'Brien F.J, Kelly D.J, Coupling Freshly Isolated CD44<sup>+</sup> Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis, Advanced Healthcare Materials, 4, (7), 2015, p1043 - 1053 Journal Article, 2015 DOI URL

Sheehy E.J., Mesallati T., Vinardell T., Kelly L., Buckley C.T. and Kelly D.J., Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx, BioResearch, 4, (1), 2015, p229 - 241 Journal Article, 2015 TARA - Full Text DOI

Sheehy EJ, Mesallati T, Vinardell T, Kelly DJ, Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels., Acta biomaterialia, 13, 2015, p245-253 Journal Article, 2015 DOI TARA - Full Text

Sridharan, R., Cameron, A.R., Kelly, D.J., Kearney, C.J., O'Brien, F.J., Biomaterial based modulation of macrophage polarization: A review and suggested design principles, Materials Today, 18, (6), 2015, 313-325 Journal Article, 2015 DOI TARA - Full Text

Luo L, Eswaramoorthy R, Mulhall K.J, Kelly D.J, Decellularization of porcine articular cartilage explants and their subsequent repopulation with human chondroprogenitor cells, Journal of the Mechanical Behavior of Biomedical Materials, 55, 2015, p21 - 31 Journal Article, 2015 URL DOI

O'Reilly, A., Kelly, D.J., Role of oxygen as a regulator of stem cell fate during the spontaneous repair of osteochondral defects, Journal of Orthopaedic Research, 34, (6), 2015, p1026-36 Journal Article, 2015 DOI

Gannon, A, Nagel, T., Kelly, D.J., Postnatal changes to the mechanical properties of articular cartilage are driven by the evolution of its collagen network, European Cells and Materials, 29, 2015, p105-123 Journal Article, 2015 TARA - Full Text DOI

Cunniffe, G.M., Vinardell, T., Murphy, J.M., (...), O'Brien, F.J., Kelly, D.J., Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing, Acta Biomaterialia, 23, 2015, p82-90 Journal Article, 2015 TARA - Full Text DOI

Thompson EM, Matsiko A, Farrell E, Kelly DJ, O'Brien FJ, Recapitulating endochondral ossification: a promising route to in vivo bone regeneration., Journal of tissue engineering and regenerative medicine, 9, (8), 2015, p889-902 Journal Article, 2015 DOI

Olvera D, Daly A, Kelly D.J, Mechanical testing of cartilage constructs, Methods in Molecular Biology, 1340, 2015, p279-287 Journal Article, 2015 DOI URL

Cunniffe G.M, Vinardell T, Thompson E.M, Daly A.C, Matsiko A, O'Brien F.J, Kelly D.J, Chondrogenically primed mesenchymal stem cell-seeded alginate hydrogels promote early bone formation in critically-sized defects, European Polymer Journal, 72, 2015, p464 - 472 Journal Article, 2015 DOI URL

Steward,Andrew J. A.J., Kelly,Daniel John D.J., Wagner,Diane R. D.R., The role of calcium signalling in the chondrogenic response of mesenchymal stem cells to hydrostatic pressure, European Cells and Materials, 28, 2014, p358-371 Journal Article, 2014

Ahearne M, Liu Y, Kelly DJ, Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair, Tissue Engineering Part A, 20, (5-6), 2014, p930 - 939 Journal Article, 2014 DOI TARA - Full Text

Almeida HV, Liu Y, Cunniffe GM, Mulhall KJ, Matsiko A, Buckley CT, O'Brien FJ, Kelly DJ, Controlled release of transforming growth factor-ß3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells., Acta biomaterialia, 10, (10), 2014, p4400-9 Journal Article, 2014 TARA - Full Text DOI

Rolfe,Rebecca A. , Nowlan,Niamh C. , Kenny,Elaine M. , Cormican,Paul , Morris,Derek W. , Prendergast, Patrick J. ., Kelly, Daniel John ., Murphy, P., Identification of mechanosensitive genes during skeletal development: Alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways, BMC Genomics, 15, (1), 2014, p48- Journal Article, 2014 TARA - Full Text DOI

Boccaccio, A., Kelly, D.J., Pappalettere, C., A mechano-regulation model to optimize design of minimally invasive percutaneous fixation devices for treatment of fractured vertebrae, Conference Proceedings of the Society for Experimental Mechanics Series, 2013 Annual Conference on Experimental and Applied Mechanics; , Lombard, IL; United States, 3-5 June, 3, 2014, pp93-98 Conference Paper, 2014 DOI

Broderick J.M, Kelly D.J, Mulhall K.J, Optimizing stem cell engineering for orthopaedic applications, Journal of the American Academy of Orthopaedic Surgeons, 22, (1), 2014, p63 - 65 Journal Article, 2014 DOI URL

Mesallati T, Buckley CT, Kelly DJ, A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes., Tissue engineering. Part C, Methods, 20, (1), 2014, p52-63 Journal Article, 2014 TARA - Full Text DOI

Rolfe, RA, Nowlan, NC, Kenny, EM, Cormican, P, Morris, DW, Prendergast, PJ, Kelly, D, Murphy, P, Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways, BMC Genomics, 15, 2014, p48- Journal Article, 2014 TARA - Full Text DOI

Mesallati,Tariq T., Buckley,Conor Timothy C.T., Kelly,Daniel John D.J., Engineering articular cartilage-like grafts by self-assembly of infrapatellar fat pad-derived stem cells, Biotechnology and Bioengineering, 111, (8), 2014, p1686-1698 Journal Article, 2014 DOI

Sheehy EJ, Vinardell T, Toner ME, Buckley CT, Kelly DJ, Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation., PloS one, 9, (3), 2014, pe90716 Journal Article, 2014 DOI TARA - Full Text

Steward AJ, Wagner DR, Kelly DJ, Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression., Journal of the mechanical behavior of biomedical materials, 38, 2014, p174-82 Journal Article, 2014 TARA - Full Text DOI

Liu Y, Buckley CT, Almeida HV, Mulhall KJ, Kelly DJ, Infrapatellar Fat Pad-Derived Stem Cells Maintain Their Chondrogenic Capacity in Disease and Can be Used to Engineer Cartilaginous Grafts of Clinically Relevant Dimensions., Tissue engineering. Part A, 20, (21-22), 2014, p3050-62 Journal Article, 2014 DOI TARA - Full Text

Mauck, R., Kelly, D., Editorial. The mechanical behaviour of cells, tissues and biomaterials, Journal of the mechanical behavior of biomedical materials, 38, 2014 Journal Article, 2014

Ahearne,Mark M., Liu,Yurong Y., Kelly,Daniel John D.J., Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair, Tissue Engineering - Part A, 20, (5-6), 2014, p930-939 Journal Article, 2014 DOI

Liu,Yurong Y., Buckley,Conor Timothy C.T., Almeida,Henrique V. H.V., Mulhall,Kevin J. K.J., Kelly,Daniel John D.J., Infrapatellar fat pad-derived stem cells maintain their chondrogenic capacity in disease and can be used to engineer cartilaginous grafts of clinically relevant dimensions, Tissue Engineering - Part A, 20, (21-22), 2014, p3050-3062 Journal Article, 2014 DOI

Carroll, S.F., Buckley, C.T., Kelly, D.J., Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad. , Journal of Biomechanics, 47, (9), 2014, p2115 - 2121 Journal Article, 2014 TARA - Full Text

Burke DP, Khayyeri H, Kelly DJ, Substrate stiffness and oxygen availability as regulators of mesenchymal stem cell differentiation within a mechanically loaded bone chamber., Biomechanics and modeling in mechanobiology, 14, (1), 2014, p93-105 Journal Article, 2014 TARA - Full Text DOI

Rolfe RA, Nowlan NC, Kenny EM, Cormican P, Morris DW, Prendergast PJ, Kelly D, Murphy P., Identification of mechanosensitive genes during skeletal development: alteration of genes associated with cytoskeletal rearrangement and cell signalling pathways., BioMedCentral Genomics, 15, 2014, p1 - 23 Journal Article, 2014 TARA - Full Text

Steward, A.J., Wagner, D.R., Kelly, D.J., Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression, Journal of the Mechanical Behavior of Biomedical Materials , 2013 Journal Article, 2013 DOI TARA - Full Text

Liu, Y., Buckley, C.T., Mulhall, K.J., Kelly, D.J., Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells, Biomaterials Science, 1, (7), 2013, p745-752 Journal Article, 2013 DOI TARA - Full Text

Burke D, Dishowitz M, Sweetwyne M, Miedel E, Hankenson KD, Kelly DJ, The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice., Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31, (10), 2013, p1585-96 Journal Article, 2013

Mesallati, T., Buckley, C.T., Nagel, T., Kelly, D.J., Scaffold architecture determines chondrocyte response to externally applied dynamic compression. , Biomechanics and Modeling in Mechanobiology, 12, (5), 2013, p889-899 Journal Article, 2013 DOI

Steward AJ, Wagner DR, Kelly DJ, The pericellular environment regulates cytoskeletal development and the differentiation of mesenchymal stem cells and determines their response to hydrostatic pressure., European cells & materials, 25, 2013, p167-178 Journal Article, 2013 TARA - Full Text URL

Nagel T, Kelly D.J, The composition of engineered cartilage at the time of implantation determines the likelihood of regenerating tissue with a normal collagen architecture, Tissue Engineering - Part A, 19, (7-8), 2013, p824 - 833 Journal Article, 2013 DOI URL

Steward, A.J., Kelly, D.J., Wagner, D.R., Calcium signaling is a key regulator of mesenchymal stem cell response to hydrostatic pressure, ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 A, 2013 Journal Article, 2013

Sheehy, E.J., Vinardell, T., Buckley, C.T., Kelly, D.J., Towards engineering whole bones via endochondral ossification, ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 B, 2013 Journal Article, 2013

Ahearne M, Kelly DJ, A comparison of fibrin, agarose and gellan gum hydrogels as carriers of stem cells and growth factor delivery microspheres for cartilage regeneration., Biomedical materials (Bristol, England), 8, (3), 2013, p035004 Journal Article, 2013 DOI

Nagel, T., Kelly, D.J., Altering the swelling pressures within in vitro engineered cartilage is predicted to modulate the configuration of the collagen network and hence improve tissue mechanical properties, Journal of the Mechanical Behavior of Biomedical Materials, 22, 2013, p22-29 Journal Article, 2013 DOI

Cilla, M., Peña, E., Martínez, M.A., Kelly, D.J., Comparison of the vulnerability risk for positive versus negative atheroma plaque morphology, Journal of Biomechanics , 46, (7), 2013, p1248-1254 Journal Article, 2013 DOI

Gannon, A.R., Kelly, D.J., The changing depth dependant properties of articular cartilage during postnatal development, ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 A, 2013 Journal Article, 2013

Sheehy EJ, Vinardell T, Buckley CT, Kelly DJ, Engineering osteochondral constructs through spatial regulation of endochondral ossification., Acta biomaterialia, 9, (3), 2013, p5484-5492 Journal Article, 2013 TARA - Full Text DOI

Thorpe SD, Nagel T, Carroll SF, Kelly DJ, Modulating Gradients in Regulatory Signals within Mesenchymal Stem Cell Seeded Hydrogels: A Novel Strategy to Engineer Zonal Articular Cartilage., PloS one, 8, (4), 2013, pe60764 Journal Article, 2013 TARA - Full Text DOI

Burke, D., Dishowitz, M., Sweetwyne, M., Miedel, E., Hankenson, K.D., Kelly, D.J., The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice, Journal of Orthopaedic Research, 31, (10), 2013, 1585-1596 Journal Article, 2013 DOI

Nagel, T., Kolditz, O., Kelly, D.J., Enhanced poromechanical properties of tissue engineered cartilage via swelling induced collagen remodelling, Poromechanics V - Proceedings of the 5th Biot Conference on Poromechanics, 5th Biot Conference on Poromechanics, BIOT 2013;, Vienna, 10-12 July, 2013, pp2158-2165 Conference Paper, 2013 DOI

Kelly, D.J., Barrie, M.B., Ross, R.A., Temple, B.A., Moses, L.M., Bausch, D.G., Housing equity for health equity: A rights-based approach to the control of Lassa fever in post-war Sierra Leone, BMC International Health and Human Rights, 2013 Journal Article, 2013

Nagel, T., Kelly, D.J. , The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture., Tissue Engineering Part A, 19, (7-8), 2013, 824-833 Journal Article, 2013 TARA - Full Text DOI

O'heireamhoin S, Buckley CT, Jones E, McGonagle D, Mulhall KJ, Kelly DJ, Recapitulating Aspects of the Oxygen and Substrate Environment of the Damaged Joint Milieu for Stem Cell-Based Cartilage Tissue Engineering., Tissue engineering. Part C, Methods, 19, (2), 2013, p117-127 Journal Article, 2013 DOI TARA - Full Text

C.T. Buckley, D.J. Kelly, Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs, Journal of the Mechanical Behavior of Biomedical Materials, 11, 2012, p102-111 Journal Article, 2012 TARA - Full Text DOI

Nagel, T., Kelly, D.J., Remodelling of collagen fibre transition stretch and angular distribution in soft biological tissues and cell-seeded hydrogels., Biomechanics and Modeling in Mechanobiology, 11, (3-4), 2012, p325-339 Journal Article, 2012 DOI

Tatiana Vinardell, Rebecca A. Rolfe, Conor T. Buckley, Eric G. Meyer, Mark Ahearne, Paula Murphy and Daniel J. Kelly, Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells, european Cells and Materials, 23, 2012, p121 - 134 Journal Article, 2012

Burke DP, Kelly DJ, Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: a mechanobiological model., PloS one, 7, (7), 2012, pe40737 Journal Article, 2012 TARA - Full Text DOI

Vinardell T, Rolfe RA, Buckley CT, Meyer EG, Ahearne M, Murphy P, Kelly DJ, Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells., European Cells & Materials, 23, 2012, p121-134 Journal Article, 2012 URL TARA - Full Text

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations., Biomechanics and Modeling in Mechanobiology, 11, (6), 2012, p869-882 Journal Article, 2012 DOI

Eoghan Maher, Arthur Creane, Caitríona Lally, Daniel J. Kelly, An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue, Journal of the Mechanical Behavior of Biomedical Materials, 12, 2012, p9-19 Journal Article, 2012 URL DOI TARA - Full Text

A.J. Steward, S.D. Thorpe, C.T. Buckley, D.R. Wagner, D.J. Kelly, Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure, Acta Biomaterialia, 8, (6), 2012, p2153-2159 Journal Article, 2012 TARA - Full Text DOI

Computational Mechanobiology in Cartilage and Bone Tissue Engineering: From Cell Phenotype to Tissue Structure in, Studies in Mechanobiology, Tissue Engineering and Biomaterials, Springer, 2012, pp341-377 , [Nagel, T., Kelly, D.J.] Book Chapter, 2012 DOI

Patient Specific Computational Modeling in Cardiovascular Mechanics in, Patient-Specific Computational Modeling, 2012, pp61-79 , [A Creane, DJ Kelly, C Lally. ] Book Chapter, 2012 DOI

Buckley CT, Meyer EG, Kelly DJ, The influence of construct scale on the composition and functional properties of cartilaginous tissues engineered using bone marrow-derived mesenchymal stem cells., Tissue engineering. Part A, 18, (3-4), 2012, p382-396 Journal Article, 2012 DOI TARA - Full Text

Maher E, Early M, Creane A, Lally C, Kelly DJ, Site specific inelasticity of arterial tissue., Journal of biomechanics, 45, (8), 2012, p1393-1399 Journal Article, 2012 TARA - Full Text DOI

Boccaccio A, Kelly DJ, Pappalettere C, A model of tissue differentiation and bone remodelling in fractured vertebrae treated with minimally invasive percutaneous fixation., Medical & biological engineering & computing, 50, (9), 2012, p947-959 Journal Article, 2012 DOI

Vinardell T, Sheehy EJ, Buckley CT, Kelly DJ, A comparison of the functionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cell sources., Tissue engineering. Part A, 18, (11-12), 2012, p1161-1170 Journal Article, 2012 DOI

Haugh, M.G., Thorpe, S.D., Vinardell, T., Duffy, G.P. and Kelly, D.J. , The application of plastic compression to modulate fibrin hydrogel mechanical properties., Journal of the Mechanical Behavior of Biomedical Materials, 16, 2012, p66-72 Journal Article, 2012 DOI

Nagel T, Kelly DJ, Mechanically induced structural changes during dynamic compression of engineered cartilaginous constructs can potentially explain increases in bulk mechanical properties., Journal of the Royal Society, Interface / the Royal Society, 9, (69), 2012, p777-89 Journal Article, 2012 TARA - Full Text DOI

T. E. Martin, D. J. Kelly, N. T. Keogh, D. Heriyadi, H. A. Singer & G. A. Blackburn, The avifauna of Lambusango Forest Reserve, Buton Island, south-east Sulawesi, with additional sightings from southern Buton, Forktail, 28, 2012, p107 - 112 Journal Article, 2012

Thomas Nagel, Daniel J. Kell, Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations, Journal of the Mechanical Behavior of Biomedical Materials, 9, 2012, p122-129 Journal Article, 2012 TARA - Full Text

Thorpe SD, Buckley CT, Steward AJ, Kelly DJ, European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate., Journal of biomechanics, 45, (15), 2012, p2483-2492 Journal Article, 2012 DOI TARA - Full Text

Gannon AR, Nagel T, Kelly DJ, The role of the superficial region in determining the dynamic properties of articular cartilage., Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, 20, (11), 2012, p1417-1425 Journal Article, 2012 DOI TARA - Full Text

Sheehy EJ, Buckley CT, Kelly DJ, Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells., Biochemical and biophysical research communications, 417, (1), 2012, p305-310 Journal Article, 2012 DOI

Liu Y, Buckley CT, Downey R, Mulhall KJ, Kelly DJ, The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad-derived stem cells., Tissue engineering. Part A, 18, (15-16), 2012, p1531-1541 Journal Article, 2012 TARA - Full Text DOI

Haugh, M.G., Meyer, E.G., Thorpe, S.D., Vinardell, T., Duffy, G.P. and Kelly, D.J., Temporal and Spatial Changes in Cartilage-Matrix Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression., Tissue Engineering Part A , 23-24, 2011, p3085-3093 Journal Article, 2011 DOI

Meyer, E.G., Buckley, C.T., and Kelly, D.J. , The Effect of Cyclic Hydrostatic Pressure on the Functional Development of Cartilaginous Tissues Engineered Using Bone Marrow Derived Mesenchymal Stem Cells., ASME 2011 Summer Bioengineering Conference, Pennsylvania, US, June 22nd-25th, ASME, 2011 Poster, 2011

Meyer, E.G., Buckley, C.T., and Kelly, D.J. , The Functional Properties of Cartilaginous Tissues Engineered Using Bone-Marrow Derived MSCs Improve As They Are Scaled Towards Geometries of Clinical Relevance. , Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA., January 13th-16th, 2011 Poster, 2011

Steward, A.J., Thorpe, S.D., Vinardell, T., Buckley, C.T., Wagner, D.R., Kelly, D.J., Cell-Matrix interactions regulate mesenchymal stem cell response to extrinsic mechanical signals, 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011 Journal Article, 2011

Jacobs, C.R., Kelly, D.J., Cell mechanics: The role of simulation, Computational Methods in Applied Sciences, 20, 2011, p1-14 Journal Article, 2011

Kasiri, S., Kelly, D.J., An argument for the use of multiple segment stents in curved arteries, Journal of Biomechanical Engineering, 133, (8), 2011 Journal Article, 2011

Boccaccio A, Kelly D.J, Pappalettere C, A mechano-regulation model of fracture repair in vertebral bodies, Journal of Orthopaedic Research, 29, (3), 2011, p433 - 443 Journal Article, 2011 DOI URL

Hoey, D.A., Kelly, D.J., Jacobs, C.R., A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 412, (1), 2011, p182-187 Journal Article, 2011 TARA - Full Text

Cummins F, Reilly PO, Flannery O, Kelly D, Kenny P, Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty. A human cadaveric mechanical study., Acta Orthopaedica, 82, (4), 2011, p433-7 Journal Article, 2011 DOI TARA - Full Text

Thorpe S.D., Buckley C.T., Steward, A.J and Kelly D.J. , Cell-Matrix Interactions Modulate Mesenchymal Stem Cell Response To Dynamic Compression, ASME 2011 Summer Bioengineering Conference, Pennsylvania, USA, June 22nd-25th, ASME, 2011 Poster, 2011

Nagel, T., Kelly, D.J., Compaction and anisotropy induced by remodeling of the collagen network's state of tension-compression transition, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p597-598 Journal Article, 2011

Early, M., Kelly D.J. , The consequences of the mechanical environment of peripheral arteries for nitinol stenting., Medical and Biological Engineering and Computing, 49, (11), 2011, p1279-1288 Journal Article, 2011 DOI

Sheehy, E.J., Vinardell, T., Meyer, E.G., Buckley, C.T. and Kelly, D.J. , The oxygen environment regulates mesenchymal stem cell expansion and chondrogenic differentiation in an in vitro cartilage defect model., Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA, January 13th-16th, 2011 Poster, 2011

Ahearne M, Buckley CT, Kelly DJ, A growth factor delivery system for chondrogenic induction of infrapatellar fat pad-derived stem cells in fibrin hydrogels., Biotechnology and Applied Biochemistry, 58, (5), 2011, p345-352 Journal Article, 2011 DOI

Computational modelling in tissue engineering; providing light in times of darkness. in, editor(s)Alyssa D. Murphy , Computational Fluid Dynamics: Theory, Analysis and Applications, Nova Science Publishers., 2011, pp1 - 70, [McCoy, R., Kelly, DJ, O'Brien, F.J. ] Book Chapter, 2011

Computational techniques for selection of biomaterial scaffolds for tissue engineering in, editor(s)P.R. Fernandes, P. Bártolo , Advances on Modelling in Tissue Engineering , Berlin, Springer, 2011, [Checa, S, Sandino, C, Byrne DP, Kelly, DJ, Lacroix, D & Prendergast, PJ] Book Chapter, 2011

Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J., Inelasticity of Human Carotid Atherosclerotic Plaque. , Annals of Biomedical Engineering, 39, (9), 2011, p2445-2455 Journal Article, 2011 DOI

Buckley, C.T., Meyer, E.G. and Kelly, D.J. , Expansion in the Presence of FGF-2 Modulates the Temporal Development of Cartilaginous Tissues Engineered Using Infrapatellar Fat Pad Derived MSCs, Annual Meeting of the Orthopaedic Research Society, Long Beach, California, USA, January 13th-16th, 2011 Poster, 2011

Cell mechanics: The role of stimulation. In: Advances on modeling in tissue engineering. in, Computational Methods in Applied Science, 20, 1-14, Nova Publishers, 2011, [Jacobs, CR, Kelly DJ. ] Book Chapter, 2011

Kasiri, S., Kelly DJ. , An Argument for the Use of Multiple Segment Stents in Curved Arteries, Journal of Biomechanical Engineering, 133, (8), 2011, p084501 Journal Article, 2011 DOI TARA - Full Text

Burke, D., Kelly, D.J., Could substrate stiffness and oxygen tension regulate stem cell differentiation during fracture healing?, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p609-610 Journal Article, 2011

Kasiri, S., Kelly, D.J. Taylor, D. , Can The Theory of Critical Distances Predict the Failure of Shape Memory Alloys?, Computer Methods in Biomechanics and Biomedical Engineering , 14, (6), 2011, p491-496 Journal Article, 2011 DOI

Cummins F, Reilly P.O', Flannery O, Kelly D, Kenny P, Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty, Acta Orthopaedica, 82, (4), 2011, p433 - 437 Journal Article, 2011 URL DOI

Sheehy E.J., Buckley C.T. and Kelly D.J., Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions., Tissue Engineering & Regenerative Medicine., 5, (9), 2011, p747-758 Journal Article, 2011 DOI

Vinardell T., Buckley C.T., Meyer E.G. and Kelly D.J. , Hydrostatic pressure and TGF-beta3 interact to regulate chondrogenesis of joint derived mesenchymal stem cells., Tissue Engineering and Regenerative Medicine International Society (TERMIS), Granada, Spain, 7th-10th June, 2011 Poster, 2011

T. Vinardell, C.T. Buckley, S. D. Thorpe, and D. J. Kelly, Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad, Journal of Tissue Engineering and Regenerative Medicine, 5, (9), 2011, p673-683 Journal Article, 2011 TARA - Full Text

E.G. Meyer, C.T. Buckley, A.J. Steward, D.J. Kelly, The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells, Journal of the Mechanical Behavior of Biomedical Materials, 4, (7), 2011, p1257-1265 Journal Article, 2011 DOI TARA - Full Text URL

Thorpe S.D., Buckley C.T., and Kelly D.J., Can dynamic compression in the absence of growth factors induce chondrogenic differentiation of bone marrow derived MSCs encapsulated in agarose hydrogels?, IFMBE Proceedings, IFMBE, 30, 2011, pp43-46 Conference Paper, 2011

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Nagel, T., Kelly, D.J., Prediction of fibre architecture and adaptation in diseased carotid bifurcations. , Biomechanics and Modeling in Mechanobiology , 10, (6), 2011, p831-843 Journal Article, 2011 DOI

Mesallati T., Buckley C.T., Nagel T. and Kelly D.J., Introducing microchannels into chondrocyte-seeded agarose hydrogels influences matrix accumulation in response to dynamic compression and TGF-â3 stimulation., IFMBE Proceedings , 8th International Conference on Cell & Stem Cell Engineering (ICCE) , 30, 2011, pp26-30 Conference Paper, 2011 DOI

Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA , 2010 Poster, 2010

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. , Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography., Computers in Biology and Medicine, 40, (4), 2010, p419-429 Journal Article, 2010 DOI

Meyer EG, Buckley CT, Thorpe SD, Kelly DJ., Low oxygen tension is a more potent promoter of chondrogenic, Journal of Biomechanics, 43, (13), 2010, p2516-2523 Journal Article, 2010 TARA - Full Text

Early, M., Kelly, D.J. , The role of vessel geometry and material properties on the mechanics of stenting in the coronary and peripheral arteries., Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 224, (3), 2010, p465-476 Journal Article, 2010

Buckley C.T., Vinardell T. and Kelly D.J., Infrapatellar Fat Pad Derived MSCs as a Potential Alternative to Chondrocytes for Cartilage Repair- Chondrogenesis in a Physiologically Relevant Low Oxygen Tension Environment., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April, 2010 Poster, 2010

Buckley, C T; Vinardell, T; Thorpe, S D; Jones, E; McGonagle, D; Kelly, D J. , Functional Properties of Cartilaginous Tissues Engineered From Infrapatellar Fat Pad Derived Mesenchymal Stem Cells. , Journal of Biomechanics , 43, (5), 2010, p920-926 Journal Article, 2010 TARA - Full Text

Daniel J. Kelly, Christopher R. Jacobs, The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells, Birth Defects Research Part C: Embryo Today: Reviews, 90, (1), 2010, p75-85 Journal Article, 2010 TARA - Full Text

Meyer EG, Haugh MG, Buckley CT, Kelly DJ., Monolayer expansion and cell seeding density influence the functional properties of cartilaginous tissues engineered using MSCs., Orthopedic Research Society Meeting, New Orleans, LA, 2010 Meeting Abstract, 2010

Buckley CT, Vinardell T, Kelly DJ., Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes., Osteoarthritis Cartilage., 18, (10), 2010, p1345-1354 Journal Article, 2010 TARA - Full Text

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Stress analysis in patient-specific models of carotid bifurcation: automated geometry reconstruction based on in vivo CT images, Computers in Biology and Medicine , 2010 Journal Article, 2010

A. Boccaccio , D.J. Kelly & C. Pappalettere, A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies, Journal of Orthopaedic Research, 29, (3), 2010, p433-443 Journal Article, 2010 TARA - Full Text

Nagel, T., Kelly, D.J. , The Influence of Fibre Orientation on the Equilibrium Properties of Neutral and Charged Biphasic Tissues, Journal of Biomechanical Engineering , 132, (11), 2010, p1-19 Journal Article, 2010

Zahedmanesh, H., Kelly, D.J., Lally, C. , Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy, Journal of Biomechanics, 43, (11), 2010, p2126-2132 Journal Article, 2010 DOI

Sheehy, E.J., Buckley C.T., and Kelly D.J. , Cartilaginous tissue engineering using chondrocytes and bone marrow derived MSCs by a combination of rotational culture and modified scaffold architecture, Tissue Engineering and Regenerative Medicine International Society - EU Meeting, Galway, Ireland,, 2010 Oral Presentation, 2010

Meyer EG, Buckley CT, Thorpe SD, Kelly DJ., Low oxygen tension: A more potent chondrogenic stimulus than dynamic compression for bone marrow derived MSCs in agarose hydrogel culture., . 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 6 - 9, 2010 Poster, 2010

Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents., Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, (1921), 2010, p2919-35 Journal Article, 2010 DOI URL TARA - Full Text

Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic compression of mesenchymal stem cells following cytokine induced differentiation augments glycosaminoglycan synthesis., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April, 2010 Poster, 2010

Meyer E.G., Buckley C.T., Haugh M.G. and Kelly D.J., The influence of expansion on the resulting functional properties of cartilaginous tissues generated from MSCs., 4th UK Mesenchymal Stem Cell Meeting, University of Leeds, UK, 14th April , 2010 Poster, 2010

Nagel T, Kelly D.J, The influence of fiber orientation on the equilibrium properties of neutral and charged biphasic tissues., Journal of biomechanical engineering, 132, (11), 2010, p114506- Journal Article, 2010 URL

Nagel, T., Kelly D.J., Modelling the Evolution of Tissue Phenotype and Structure During Skeletal Regeneration, Tissue Engineering and Regenerative Medicine International Society - EU Meeting, Galway, Ireland, 2010 Conference Paper, 2010

Mesallati, T.S., Buckley, C.T., Kelly, D.J., The effect of introducing microchannels into dynamically compressed chondrocyte-seeded hydrogels, 8th International Conference on Cell & Stem Cell Engineering (ICCE), , Dublin, 11-12th June 2010. , 2010 Oral Presentation, 2010

Thorpe, S. D., Buckley, C. T., Vinardel, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , The response of bone marrow derived mesenchymal stem cells to dynamic compression following TGF-â3 induced chondrogenic differentiation, Annals of Biomedical Engineering , 38, (9), 2010, p2896-2909 Journal Article, 2010 DOI

Meyer E.G., Buckley C.T., Thorpe S.D. and Kelly D.J., Low oxygen tension: A more potent chondrogenic stimulus than dynamic compression for bone marrow derived MSCs in agarose hydrogel culture., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010 Poster, 2010

Thorpe S.D., Buckley C.T., Vinardell T., O'Brien F.J., Campbell V.A. and Kelly D.J., Dynamic Compression Post TGF-â3 Induced Differentiation Augments Chondrogenesis of Mesenchymal Stem Cells., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010 Poster, 2010

Partap S, Plunkett N, Kelly DJ, O'Brien F., Rest Periods During Bioreactor Culture Restore Mechanosensitivity and Enhance Osteogenesis, 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, USA, March 6 - 9, 2010 Poster, 2010

Meyer E.G., Buckley C.T., Thorpe, S.D. and Kelly D.J. , Low Oxygen Tension is a More Potent Regulator of Chondrogenic Differentiation Than Dynamic Compression for Bone Marrow Derived Mesenchymal Stem Cells., Tissue Engineering and Regenerative Medicine International Society - EU Meeting, Galway, Ireland, 2010 Conference Paper, 2010

Meyer E.G., Buckley C.T., Kelly D.J, The Effect of Cyclic Hydrostatic Pressure and Low Oxygen Tension on the Chondrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells., 8th International Conference on Cell & Stem Cell Engineering (ICCE), , Dublin, 11-12th June, 2010 Oral Presentation, 2010

Partap, S., Plunkett, N.A., Kelly, D.J., O'Brien, F.J. , Stimulation of Osteoblasts Using Rest Periods during Bioreactor Culture on Collagen-Glycosaminoglycan Scaffolds., Journal of Material Science, 21, (8), 2010, p2325-2330 Journal Article, 2010 URL DOI

Meyer E.G., Haugh M.G., Buckley C.T. and Kelly D.J. , Monolayer expansion and cell seeding density influence the functional properties of cartilaginous tissues engineered using MSCs., 56th Annual Meeting of the Orthopaedic Research Society, Morial Convention Center Hall H, New Orleans, Louisiana, March 6 - 9, 2010 Poster, 2010

Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C., Kelly, D.J., Mechanical characterization of fresh human carotid atherosclerotic plaque, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART B), 2009, p1307-1308 Journal Article, 2009

Early, M., Kelly, D.J., Why are rates of restenosis higher in peripheral arteries than coronary arteries? A computational study, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p385-386 Journal Article, 2009

Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. , Tensile and compressive properties of fresh human carotid atherosclerotic plaques. , Journal of Biomechanics, 42, (16), 2009, p2760-2767 Journal Article, 2009 DOI TARA - Full Text

Buckley CT, Thorpe SD, O'Brien FJ, Robinson AJ, Kelly DJ, The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels., Journal of the Mechanical Behavior of Biomedical Materials, 2, (5), 2009, p512-21 Journal Article, 2009 DOI URL

Vinardell, T., Thorpe, S., Buckley, C., Kelly, D.J., Chondrocytes demonstrate superior integration than mesenchymal stem cells in a cartilage explant defect model., Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009 Poster, 2009

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Patient specific finite element modelling of the carotid bifurcation, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p529-530 Journal Article, 2009

Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 3rd International Conference on Mechanics of Biomaterials and Tissues, Clearwater Beach, USA, 2009 Oral Presentation, 2009

Vinardell, T; Thorpe, S D; Buckley, C T; Kelly, D J, Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model, Annals of Biomedical Engineering, 37, (12), 2009, p2556-2565 Journal Article, 2009 TARA - Full Text

Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., A comparative study of shear stresses in collagen-GAG and calcium phosphate scaffolds in bone tissue-engineering bioreactors., Tissue Engineering Part A, 15, (5), 2009, p1141-1149 Journal Article, 2009 URL DOI

Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., A comparative study of shear stresses in collagen-glycosaminoglycan and calcium phosphate scaffolds in bone tissue-engineering bioreactors, Tissue Engineering - Part A, 15, (5), 2009, p1141-1149 Journal Article, 2009

Buckley C.T., Thorpe S.D. and Kelly D.J., The Influence of Dynamic Rotational Culturing on Chondrocyte Seeded Microchanneled Agarose Hydrogels, Tissue Engineering Part A, 15, (11), 2009, p3213-3220 Journal Article, 2009

Vinardell T, Thorpe S, Buckley C, Kelly D., Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, USA, 2009 Poster, 2009

Vinardell T, Buckley C, Thorpe S, Kelly D , Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., European Cells and Materials , X European Cells and Materials Conference, Stem Cells for musculoskeletal regeneration, Davos, Switzerland, June 29- July 1, 18, (1), 2009, pp63 Poster, 2009

Jungreuthmayer, C., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J., Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model., Medical Engineering and Physics , 31, (4), 2009, p420-427 Journal Article, 2009 TARA - Full Text URL DOI

Pericevic, I., Lally, C., Toner, D., Kelly, D.J. , The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents, Medical Engineering and Physics , 31, (4), 2009, p428-433 Journal Article, 2009 TARA - Full Text DOI URL

Vinardell T., Thorpe S.D., Buckley C.T. and Kelly D.J. , Chondrogenesis and integration of bone marrow derived mesenchymal stem cells and chondrocytes within an in vitro cartilage defect repair model. , Annals of Biomedical Engineering , 37, (12), 2009, p2556 - 2565 Journal Article, 2009

Buckley, C.T., Thorpe, S.D., Kelly, D.J. , Engineering of large cartilaginous constructs through the use of microchanneled hydrogels and rotational culture, Tissue Engineering A, 15, (11), 2009, p3213-3220 Journal Article, 2009 TARA - Full Text DOI

Thorpe, S., Vinardell, T., Buckley, C., Kelly, D.J., Dynamic Compressive Loading can Inhibit Chondrogenesis of Bone Marrow Derived Mesenchymal Progenitor Cells, Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009 Poster, 2009

Buckley, C.T., Thorpe, S.D., O'Brien, F.J., Robinson, A.J., Kelly, D.J. , The effect of concentration, cooling rate and cell seeding density on the initial mechanical properties of agarose hydrogels., Mechanical Behaviour of Biomedical Materials , 2, (5), 2009, p512 - 521 Journal Article, 2009 DOI TARA - Full Text

Vinardell T, Buckley C.T. and Kelly D.J. , Mechanical Behaviour of Cartilaginous Tissues Engineered from Mesenchymal Stem Cells Isolated from Different Tissue Sources, Third International Conference on Mechanics of Biomaterials and Tissues, Clearwater Beach, Florida, USA, 13 - 17 December , 2009 Poster, 2009

Vinardell T, Thorpe S, Buckley C, Kelly D. , Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 3rd UK Mesenchymal Stem Cell Meeting, Sheffield, UK, 2009 Poster, 2009

Thomas Nagel and Daniel J. Kelly, Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair, Biomechanics and Modeling in Mechanobiology, 9, (3), 2009, p359-372 Journal Article, 2009 TARA - Full Text

Haut Donadue, T., Thorpe, S., Buckley, C., Kelly, D.J., The Response of Inner vs. Outer Zone Meniscal Cells to Unconfined Compression. , Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009 Poster, 2009

Michael Early; Catriona Lally; Patrick J. Prendergast; Daniel J. Kelly, Stresses in peripheral arteries following stent placement: a finite element analysis, Computer Methods in Biomechanics and Biomedical Engineering, 12, (1), 2009, p25 - 33 Journal Article, 2009 DOI TARA - Full Text URL

Buckley, C., Thorpe, S., Kelly, D.J. , The Effect of Dynamic Rotational Culturing on Chondrocytes in a Microchannel Agarose Hydrogel Environment., Trans. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, 2009 Poster, 2009

Thorpe, S., Buckley, C., Kelly, D.J., Chondrogenesis of Mesenchymal Stem Cells is Differentially Regulated by Temporal Application of Dynamic Compression, ECM X: Stem Cells for Musculoskeletal Regeneration, Davos, Switzerland, 2009 Poster, 2009

Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J, A comparative numerical 3D CFD of two tissue engineering scaffolds subjected to fluid flow., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Thorpe, S. D., Buckley, C. T., Vinardell, T., O'Brien, F. J., Campbell, V. A., Kelly, D. J. , Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 337, (2), 2008, p458-462 Journal Article, 2008 URL TARA - Full Text DOI

Early, M., Kelly, D.J, Influence of stent type and arterial properties and geometry on stent-artery interactions, 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2008, 30 p Proceedings of a Conference, 2008

Reilly, G., Fitzpatrick, D.(ed.), Proceedings of Bioengineering in Ireland, 2008, 97 p Proceedings of a Conference, 2008

Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , Dublin, 2008, 28 p Proceedings of a Conference, 2008

Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2008, 44 p Proceedings of a Conference, 2008

Pericevic, I., Lally, C., Toner, D., Kelly, D.J., FE analysis of stent expansion considering the influence of plaque composition and inflation pressure., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Boccaccio A, Prendergast PJ, Pappalettere C, Kelly DJ, Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period, Medical and Biological Engineering and Computing, 46, (3), 2008, p283 - 298 Journal Article, 2008 URL DOI TARA - Full Text

Byrne, D. P., Lacroix, D., Kelly, D. J., Prendergast, P. J., Modelling cell dispersal in the fracture callus., 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Vard, J.P., Kelly, D.J., Blayney, A.W. and Prendergast, P.J. , The influence of ventilation tube design on the magnitude of stress imposed at the implant/tympanic membrane interface, Medical Engineering and Physics, 30, (2), 2008, p154-163 Journal Article, 2008 TARA - Full Text URL DOI

Reilly, G., Fitzpatrick, D.(ed.), Proceedings of Bioengineering in Ireland, Dublin, 2008, 7 p Proceedings of a Conference, 2008

Kearney, P., Lally, C., Kelly, D.J., An iterative diffusive-convective model of drug transport and binding in the artery wall, 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2008, 31 p Proceedings of a Conference, 2008

Reilly, G., Fitzpatrick, D.(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, 2008, 59 p Proceedings of a Conference, 2008

Reilly, G., Fitzpatrick, D.(ed.), Proceedings of Bioengineering in Ireland, Dublin, 2008, 2008, 49 p Proceedings of a Conference, 2008

Buckley, C., Gallagher, J., Thorpe, S., Kelly, D.J. , In vitro dynamic loading of micro-channelled chondrocyte seeded hydrogel constructs. , 16th Congress of the European Society of Biomechanics, Lucerne, Switzerland, edited by July 6th-9th , 2008 Conference Paper, 2008

Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 63 p Proceedings of a Conference, 2007

Boccaccio, A., Pappalettere, C., Kelly, D.J, The influence of expansion rates on mandibular distraction osteogenesis: a computational analysis, Annals of Biomedical Engineering, 35, (11), 2007, p1940 - 1960 Journal Article, 2007 URL DOI TARA - Full Text

D.J. Kelly, A. Crawford, S.C. Dickinson, T.J. Sims, A.P. Hollander, P.J. Prendergast and P.V. Hatton, Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage, Journal of Materials Science: Materials in Medicine, 18, (2), 2007, p273-281 Journal Article, 2007 TARA - Full Text DOI URL

Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 75 p Proceedings of a Conference, 2007

Byrne, DP, Lacroix, D, Kelly, DJ, Plannel, J, Prendergast, PJ, Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus, and dissolution rate of a scaffold: application of mechanobiological models in tissue engineering, Biomaterials, 28, (36), 2007, p5544 - 5554 Journal Article, 2007 DOI URL

Marenzana, M, Kelly, DJ, Prendergast, PJ, Brown, RA, A collagen-based interface construct for the assessment of cell-dependent mechanical integration of tissue surfaces, Cell and Tissue Research, 327, (2), 2007, p293 - 300 Journal Article, 2007 URL DOI

Byrne, D.P., Lacroix, D., Planell, J.A., Kelly, D.J., Prendergast, P.J., Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: Application of mechanobiological models in tissue engineering, Biomaterials, 28, (36), 2007, p5544-5554 Journal Article, 2007

Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 78 p Proceedings of a Conference, 2007

D.P. Byrne, D. Lacroix, D.J. Kelly and P.J. Prendergast, The effect of loading on bone regeneration in a regular structured scaffold, Proceedings of the 3rd International Conference on Computational Bioengineering, 3rd International Conference on Computational Bioengineering, Universidad Central de Venezuela, Caracas , edited by M. Cerrolaza , 2007, pp215-220 Conference Paper, 2007

Byrne, D.P., Lacroix, D., Kelly, D.J., Prendergast, P.J., Finite element modeling of dissolution of a regular structured scaffold for tissue engineering, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp134-135 Conference Paper, 2007

Guerin, S., O'Reilly, P., O'Byrne, J., Kelly, D.J, Hydrogen peroxide as a clinical irrigation solution: A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface, Biomedical Materials and Engineering, 17, (6), 2007, p379 - 386 Journal Article, 2007 URL TARA - Full Text

Guerin, S.R., MacNiochaill, R., O'Reilly, P., O'Byrne, J., Kelly, D.J., A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface, Bio-Medical Materials and Engineering, 17, (6), 2007, p379-386 Journal Article, 2007

Early, M. & Kelly, DJ, A study of the factors affecting stresses in peripheral arteries following stent placement, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp58-59 Conference Paper, 2007

Jungreuthmayer, C., Jaasma, M.J., Kelly, D.J., O'Brien, F.J., 3D numerical simulation of a flow perfusion bioreactor for bone tissue engineering, Proceedings of the 2007 Workshop of the European Society of Biomechanics, Workshop of the European Society of Biomechanics, Dublin, Ireland, 2007, pp108-109 Conference Paper, 2007

Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 33 p Proceedings of a Conference, 2007

Buchanan, F., Dunne, N., Orr, J.,(ed.), Bioengineering in Ireland, Proceedings of Bioengineering in Ireland, Dublin, 2007, 77 p Proceedings of a Conference, 2007

McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 82 p Proceedings of a Conference, 2006

McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 106 p Proceedings of a Conference, 2006

McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 115 p Proceedings of a Conference, 2006

McHugh, P.E., O'Mahoney, D., FitzPatrick, D.(ed.), Bioengineering in Ireland , Proceedings of Bioengineering in Ireland , 2006, 56 p Proceedings of a Conference, 2006

Early, M., Kelly, D.J., An analysis of stresses in peripheral arteries following stenting using the finite element method, Journal of Biomechanics, Proceedings of the V World Congress of Biomechanics, Munich, Germany, 39, (Supp 1), 2006, ppS328 Conference Paper, 2006

Byrne, D.P., Prendergast, P.J., Kelly, D.J., Optimisation of scaffold porosity using a stochastic model for cell proliferation and migration in mechanobiological simulations, Journal of Biomechanics , Proceedings of the V World Congress of Biomechanics, Munich, Germany., 39, (1), 2006, ppS413 Conference Paper, 2006

Stents in, editor(s)Akay M , Wiley Encyclopaedia of Biomedical Engineering, John Wiley & Sons, 2006, [C Lally, DJ Kelly, PJ Prendergast] Book Chapter, 2006 URL

Kelly, D.J. & Prendergast, P.J., Computational optimization of the mechanical properties for a scaffold used in osteochondral defect repair, American Society of Mechanical Engineers Summer Bioengineering Meeting, 52, 2006 Meeting Abstract, 2006

Prendergast, P.J., Kelly, D.J., McMahon, L.A., Campbell, V.A. , A computational optimization of scaffolds for tissue engineering of cartilage., Tissue Engineering, Abstracts of 8th TESI Annual Meeting 2005, Shanghai, China, October 22-25, 12, 2006, pp1024 Meeting Abstract, 2006

Kelly DJ, Prendergast PJ, Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair, Tissue Engineering, 12, (9), 2006, p2509 - 2519 Journal Article, 2006 URL DOI TARA - Full Text

Crawford, A., Kelly, D.J., Dickinson, S.C., Sims, T.J., Mundy, J., Hollander, A.P., Prendergast, P.J., Hatton, P.V., Matrix proteins as predictive markers of the mechanical strength of engineered cartilage, European Cells and Materials, 11, (SUPPL.2), 2006 Journal Article, 2006

Kelly, D.J. & Boccaccio, A, Tissue differentiation and bone regeneration in an osteootmized and distracted mandible, Journal of Biomechanics, Proceedings of the V World Congress of Biomechanics, Munich, Germany, 39, (Supp 1), 2006, ppS415 Conference Paper, 2006

M Moretti, D Wendt, S C Dickinson, T J Sims, A P Hollander, D J Kelly, P J Prendergast, M Heberer, I Martin, Effects of in vitro pre-culture on the in vivo development of human engineered cartilage in an ectopic model, Tissue Engineering, 11, (9-10), 2005, p1421 - 1428 Journal Article, 2005 DOI URL

Mechanobiological models of Skeletal Tissue Differentiation in, editor(s)Tomasz Lekszycki & Pawel Maldyk , Biomaterials in Orthopaedic Practice, Warsaw, Polish Academy of Sciences,, 2005, pp1 - 20, [DJ Kelly] Book Chapter, 2005 TARA - Full Text

Vard, J.P., Prendergast, P.J., Kelly, D. & Blayney, A.J., Investigating the theory of grommet induced tympanosclerosis using finite element analysis, Proceedings of Bioengineering in Ireland , Bioengineering in Ireland , edited by FitzPatrick, D.P., Senouci, M., , 2005, pp7 Conference Paper, 2005

Prendergast, P.J., Kelly, D.J., Perez, M.A., Computational models for the study of the mechanobiology of bone regeneration, European Society of Biomechanics Thematic Workshop: Mechanobiology of Cells and Tissue Regeneration, Leuven, Aug 2005, 2005, pp29-30 Conference Paper, 2005

DJ Kelly and PJ Prendergast, Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects, Journal of Biomechanics, 38, (7), 2005, p1413 - 1422 Journal Article, 2005 URL DOI TARA - Full Text

Kelly, D.J. & Prendergast, P.J. , Using a mechano-regulation model for tissue differentiation to design an optimised scaffold for osteochondral defect repair, Proceedings of the 14th Conference of the European Society of Biomechanics, 14th Conference of the European Society of Biomechanics, S-Hertogenbosch, The Netherlands, 2004 Conference Paper, 2004

DJ Kelly, PJ Prendergast, A Mechanobiological analysis of osteochondral defect repair, Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, California, 2004, 2004 Poster, 2004

DJ Kelly and PJ Prendergast, Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis, Medical & Biological Engineering & Computing, 45, (1), 2004, p9 - 13 Journal Article, 2004 DOI URL

Modelling the response of cells to mechanical stimulation in, editor(s)Józef Joachim Telega , Modelling in Biomechanics: Lecture Notes 19 of AMAS, Warsaw, Institute of Fundamental Technological Research, 2004, pp159-189 , [PJ Prendergast, DJ Kelly, JG McGarry.] Book Chapter, 2004

Kelly, D.J., Waller, M.A., Dickinson, S.C., Hollander, A.P., Crawford, A.C., Hatton, P.V. & Prendergast, P.J., Can a functional engineered cartilage tissue be grown in a static culture?, Proceedings of Bioengineering in Ireland, Bioengineering in Ireland, edited by Fitzpatrick, D.P., McCormack, B.A.O., McCormack, D. , 2004, pp20 Conference Paper, 2004

Kelly, D.J. & Prendergast, P.J. , The poor quality repair tissue that forms in osteochonrdal defects can be attributed to the local mechanical environment within the defect, Proceedings of Bioengineering in Ireland, Bioengineering in Ireland, edited by Fitzpatrick, D.P., McCormack, B.A.O., McCormack, D. , 2003, pp75 Conference Paper, 2003

D.J. Kelly, P.J. Prendergast, Variations in chondrocyte deformation throughout cartilage during loading: A poroelastic finite element analysis, ACTA of Bioengineering and Biomechanics: Proceedings of the 13th Conference of European Society of Biomechanics, 2003, 2003 Meeting Abstract, 2003

Lyons, A.D., Lally, C., Kelly, D.J., Lang, E., Blayney, A.W. & Prendergast, P.J. , Elasticity of tragal cartilage and Temporalis Fascia, and tympanic membrane vibration after tympanoplasty using these tissues, Proceedings of Bioengineering in Ireland, Bioengineering in Ireland, edited by Fitzpatrick, D.P., McCormack, B.A.O., McCormack, D. , 2003, pp57 Conference Paper, 2003

Kelly, D.J. & Prendergast, P.J., The influence of defect size and scaffold material properties on osteochondral defect repair., Proceedings of the 2003 Annual Fall Meeting of the Biomedical Engineering Society, Proceedings of the 2003 Annual Fall Meeting of the Biomedical Engineering Society, 2003 Conference Paper, 2003

Kelly, D.J. & Prendergast, P.J., A mechanobiological analysis of osteochondral defect repair, Trans. U.S. 48th Orthopaedic Research Society, 14th Conference of the European Society of Biomechanics, San Francisco, 2003, pp666 Conference Paper, 2003

Kelly, D J; Prendergast, P J; Blayney, A W, The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses, Otology & Neurotology: Official Publication Of The American Otological Society, American Neurotology Society [And] European Academy Of Otology And Neurotology, 24, (1), 2003, p11 - 19 Journal Article, 2003 URL TARA - Full Text

Moretti, M., Wendt, D., Dickinson, S., Hollander, A., Kelly, D.J., Prendergast, P.J., Herberer, M. & Martin, I. , In vivo development of human engineered cartilage is enhanced by the in vivo pre-culture, only under specific conditions., Trans. U.S. 48th Orthopaedic Research Society, 14th Conference of the European Society of Biomechanics, San Francisco, 2003, pp698 Conference Paper, 2003

Kelly, D.J. & Prendergast, P.J. , Variations in chondrocyte deformation throughout cartilage during loading: a poroelastic finite element analysis. , Acta of Biomechanics and Bioengineering, 4, (1), 2002, pp439-440 Conference Paper, 2002

Kelly, D.J. & Prendergast, P.J., An investigation of middle-ear biomechanics using finite element modelling,, American Society of Mechanical Engineers Summer Bioengineering Meeting, 50, 2001, pp369-370 Conference Paper, 2001

Kelly, D.J., Prendergast, P.J., Rafferty, M. & Blayney, A.W., Grommet design affects the vibratory motion of the tympanic membrane, Proceedings of the 12th Conference of the European Society of Biomechanics, 12th Conference of the European Society of Biomechanics, Royal Academy of Medicine in Ireland, Dublin, 2000, pp191 Conference Paper, 2000

Prendergast, P J; Kelly, D J; Rafferty, M; Blayney, A W, The effect of ventilation tubes on stresses and vibration motion in the tympanic membrane: a finite element analysis, Clinical Otolaryngology And Allied Sciences, 24, (6), 1999, p542 - 548 Journal Article, 1999 URL DOI

Non-Peer-Reviewed Publications

Sheehy E.J., Buckley C.T. and Kelly D.J., Rotational culture differentially regulates chondrogenesis of bone marrow derived MSCs and chondrocytes., Proceedings of the 16th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland. , 2010 Oral Presentation, 2010

Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells, Department of Orthopedics, Rush University Medical Center, Chicago, Apr 21, 2010 Invited Talk, 2010

Kelly DJ., The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , , 2010., Graduate Seminar Series, Engineering Mechanics Department, Michigan Technological University, Mar 25, 2010 Invited Talk, 2010

Kelly DJ., "The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells". , Aerospace and Mechanical Engineering, University of Notre Dame, Apr 22, 2010 Invited Talk, 2010

Vinardell T, Buckley C, Thorpe S, Kelly D, Functional properties of cartilaginous tissues generated from mesenchymal stem cells isolated from different tissue sources., 16th Annual Conference of the Section of Bioengineering, Dublin, Ireland, 2010 Oral Presentation, 2010

Meyer, Eric, Low oxygen tension is a more potent regulator of chondrogenic differentiation than dynamic compression. , Bioengineering in Ireland., Malahide, Ireland, Jan. 22, 2010 Conference Paper, 2010

Kelly DJ, The role of environmental factors in regulating chondrogenesis of mesenchymal stem cells , Dept of Biomedical Engineering Graduate Seminar Series, Columbia University, New York, Nov 6,, 2009 Invited Talk, 2009

Kelly DJ., Mechanobiology of mesenchymal stem cells for articular cartilage repair , Seminars in Orthopaedic Science, REMEDI, NUI Galway, Ireland, May 1, 2009 Invited Talk, 2009

Kelly DJ., In Vitro and In Silico Models of Mechano-regulated Skeletal Tissue Differentiation, New York City Bone Seminar Series, CUNY Graduate Center, New York, Dec 8, 2009 Invited Talk, 2009

Vinardell T, Thorpe S, Buckley C, Kelly D. , Chondrogenesis of bone marrow mesenchymal stem cells and chondrocytes- an in vitro cartilage defect repair model., 15th Annual Conference of the Section of Bioengineering, Limerick, Ireland, edited by McGloughlin and M. Walsh , 2009 Oral Presentation, 2009

Kelly DJ., In vitro and in silico models of cell based therapies for cartilage repair , QUB Biomaterials Symposium & Workshop, Queens University Belfast, April 7, 2009 Invited Talk, 2009

Kelly DJ., Cartilage and Bone Mechanobiology and Tissue Engineering, Short course delivered to the Interpolytechnic School of Doctorate, Politecnico di Bari, Italy, June 8-10, 2009 Invited Talk, 2009

Kelly DJ., Computational Modelling in the Design of Scaffolds for Bone and Cartilage Tissue Engineering., Institution of Mechanical Engineers Seminar: Computer Simulations in Medical Engineering, London, Nov 19, 2008 Invited Talk, 2008

Kelly DJ., Linear elastic analysis and building a finite element model, Workshop of the European Society of Biomechanics, Dublin, Ireland, August 26-28, 2007 Invited Talk, 2007

Kelly DJ., Linear elastic analysis and building a finite element model, 2007 Workshop of the European Society of Biomechanics, Dublin, Ireland, August 26-28, 2007 Invited Talk, 2007

Kelly DJ., Tissue differentiation steps towards bone formation., European Cells and Materials Conference on Bone Tissue Engineering,, Davos, Switzerland, June 25-28, 2007 Invited Talk, 2007

Mechanobiological Models of Skeletal Tissue Differentiation in, editor(s)Tomasz Lekszycki & Pawel Maldyk , Biomaterials in Orthopaedic Practice, Warsaw, Polish Academy of Sciences, 2005, pp49 - 68, [Kelly DJ] Book Chapter, 2005

Kelly DJ., Mechanobiological models of skeletal tissue differentiation. , Biomaterials in Orthopaedic Practice Workshop, Warsaw, Poland, June , 2005 Invited Talk, 2005

Modelling the response of cells to mechanical stimulation in, editor(s)Józef Joachim Telega , Modelling in Biomechanics, Warsaw, Polish Academy of Sciences, 2005, pp159 - 189, [Prendergast, PJ, Kelly, DJ, McGarry, JG] Book Chapter, 2005

Portmann D.; Huy P.T.B.; Aran J.M.; Blayney A.W.; Fraysse B.; Katz B.H.; Kelly D.J.; Prendergast P.J., The symphonix symposium understanding the ear advances in knowledge, Revue de Laryngologie Otologie Rhinologie, 121, (1), 2000, p65 - 72 Journal Article, 2000

Research Expertise

Description

Articular cartilage tissue engineering: Dr. Kelly's lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic. Bone, joint and limb regeneration: Dr. Kelly's lab have also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting. Stem cell mechanobiology: Dr. Kelly's lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.

Projects

  • Title
    • Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports
  • Summary
    • Osteoarthritis (OA), the most common form of arthritis, is a serious disease of the joints affecting nearly 10% of the population worldwide. The onset of OA has been associated with defects to articular cartilage that lines the bones of synovial joints. Current strategies to treat articular cartilage defects are ineffective and/or prohibitively expensive. The aim of ANCHOR is to develop and commercialise a new medicinal product for articular cartilage regeneration that recruits endogenous bone marrow derived stem cells into an extracellular matrix derived scaffold anchored to the subchondral bone by 3D printed polymeric supports. By recruiting endogenous cells into a supporting scaffold, ANCHOR will obviate the need for pre-seeding scaffolds with cells prior to implantation into cartilage defects, thereby dramatically reducing the cost and complexity of the repair procedure. It will also overcome the need for suturing of a scaffold into a cartilage defect, which is a very time consuming and technically challenging surgical procedure. Finally, the inherent chondro-inductivity of the cartilage ECM derived scaffolds developed by the applicant will maximise the potential for hyaline cartilage regeneration. The project will leverage the applicants extensive experience in ECM derived biomaterials and 3D printing to develop a new product with significant commercial potential. The impact of ANCHOR will be multi-faceted: it will transform how damaged joints are treated by orthopaedic surgeons, it will create economic value through the commercialization of IP, and most importantly it will improve patient experience and their long-term health and well-being.
  • Funding Agency
    • European Research Council
  • Date From
    • Jan 2018
  • Date To
    • June 2019
  • Title
    • PreclinicAl Infrastructure Resource
  • Summary
    • A significant investment has been made in Ireland in the research underpinning the development of new medical devices and implants to treat a range of diseases - from heart failure to arthritis. In order to commercialise this basic research and to ensure its translation into the clinic, there is a clear need for improved pre-clinical facilities to assess the safety and efficacy of these new approaches. This project will enable the development of a state of the art surgical facility for the pre-clinical evaluation of Advanced Therapeutic Medicinal Products (ATMPs) and next generation medical devices.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • Jan 2017
  • Date To
    • Dec 2018
  • Title
    • CarBon - Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis
  • Summary
    • Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. Understanding and controlling the dual character of cartilage is pivotal: insufficient transition impairs bone healing, and undesired transition to bone leads to osteoarthritis. In CarBon, state of the art in vitro, in silico and in vivo models will be uniquely combined to elucidate how this transition is orchestrated and how it can be modulated. In a multifactorial approach, a network of 14 young scientists will aim to identify the biological and physical factors that determine the fate of cartilage. Knowledge from the fields of tissue engineering, cartilage and bone developmental biology and pathobiology will be combined with skills from the disciplines of cell biology, computational modelling, biotechnology (bioreactors, biomaterials) and drug discovery.
  • Funding Agency
    • H2020
  • Date From
    • Jan 2017
  • Date To
    • Dec 2020
  • Title
    • 3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration. (ERC-2014-CoG -647004)
  • Summary
    • Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide 'off-the-shelf', patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate anatomically accurate, biomimetic constructs that can be used to regenerate both the cartilage and bone in a diseased joint. If successful, such an implant would form the basis of a truly transformative therapy for treating degenerative joint disease.
  • Funding Agency
    • European Research Council
  • Date From
    • 2015
  • Date To
    • 2020
  • Title
    • A decellularised extracellular matrix derived scaffold incorporating freshly isolated joint tissue derived cells as a bioactive implant for cartilage repair. (CF/2014/4325)
  • Summary
    • We have developed a new 'single-stage' or 'off-the-shelf' approach to articular cartilage regeneration that consists of a chondro-inductive extracellular matrix (ECM) derived scaffold seeded with freshly isolated joint tissue derived stromal cells that are processed 'in-theatre'. The primary objective of this project is to evaluate the efficacy of this 'single-stage' or 'in-theatre' therapy for articular cartilage regeneration in a large animal model study.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2014
  • Date To
    • 2017
  • Title
    • A tissue engineered biological joint replacement prosthesis for the treatment of degenerative joint disease (12/IA/1554)
  • Summary
    • Realising an efficacious therapeutic solution for treating osteoarthritis remains elusive and is considered one of the greatest challenges in the field of orthopaedic medicine. Tissue engineering aims to replace or regenerate damaged or diseased tissues through the combined use of cells, scaffolds and physio-chemical cues. The aim of this proposal is to tissue engineer a biological joint replacement prosthesis using mesenchymal stem cells (MCSs) as the basis of a novel therapy for treating degenerative joint disease. This will be achieved in part by recapitulating key aspects of normal bone and joint development, specifically the process of endochondral ossification where a hypertrophic cartilaginous intermediary is replaced by bone. The first phase of the project will attempt to tissue engineer a hypertrophic cartilaginous construct using MSCs that mimics the anatomy of the knee joint and then demonstrate that such a construct will be replaced by bone in vivo. The second phase of the project will use MSCs to engineer a stable layer of articular cartilage on the surface of the hypertrophic construct. The final phase of the project will evaluate the potential of the proposed biological prosthesis to regenerate both the articular cartilage and underlying bone of the medial femorotibial joint.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2013
  • Date To
    • 2018
  • Title
    • Porous decellularized hypertrophic tissue engineered cartilage as a scaffold for large bone defect healing
  • Summary
    • Most bones develop by endochondral ossification, the replacement of hypertrophic cartilaginous templates with bone. It has recently been demonstrated that adult human bone marrow derived mesenchymal stem cells (MSCs) can be used to engineer cartilaginous tissues that act as a template for bone formation in vivo21. While conceptually appealing as a treatment option for bone regeneration, clinical translation of any cell-based therapy is hampered by high costs and significant regulatory challenges. The hypothesis of this proposal is that a porous scaffold derived from decellularized hypertrophic cartilage engineered using allogenic bone marrow derived MSCs will be highly osteoinductive, support vascularisation, allow osteoclastic resorption and will promote bone formation by host progenitor cells. This scaffold will be compared to a highly porous collagen-hydroxyapatite scaffold which has been designed specifically for bone repair. The scaffold will be evaluated by demonstrating its ability to induce ectopic bone formation in a subcutaneous nude mouse model. If proven effective, such a treatment option would provide an off-the-shelf solution for the treatment of large bone defects.
  • Funding Agency
    • AO Foundation
  • Date From
    • 01/01/2012
  • Date To
    • 31/12/2013
  • Title
    • Novel mesenchymal stem cell based therapies for articular cartilage repair
  • Summary
    • Once damaged articular cartilage has a limited reparative capacity and thus lesions often progress to arthritis. This has motivated the development of cell based therapies for the repair of cartilage defects such as autologous chondrocyte implantation (ACI). Such therapies are limited in two ways. Firstly, they do not result in the regeneration of hyaline cartilage and hence the repair is temporary. Secondly, widespread adaptation into the clinical setting is impeded by practical issues such as the high cost and time required for culture expansion of chondrocytes. The applicant is of the belief that both issues cannot currently be addressed by a single new therapy. Therefore the proposed project will put forward separate solutions to both issues. The first theme of the project will determine whether freshly isolated (not culture expanded) infrapatellar fat pad derived cells, embedded in a hydrogel containing microbead-encapsulated growth factors, can used to engineer functional cartilage tissue. A component of this theme will involve magnetic microbead selection for cells with surface markers associated with mesenchymal stem cells (MSCs). Theme 2 of the proposed project will explore an alternative therapy for cartilage defect repair. Specifically, the objective is to tissue engineer in vitro a functional tissue with a zonal structure mimicking that of normal articular cartilage using MSCs. It is hypothesised that such a zonal structure can be generated by controlling the oxygen tension and mechanical environment within the developing tissue. The final theme of the project will be to determine if repairing high-load bearing cartilage defects using such tissue engineered grafts will result in significantly improved repair compared to ACI.
  • Funding Agency
    • European Research Council
  • Date From
    • 2010
  • Date To
    • 2015
  • Title
    • Mechanobiology of mesenchymal stem cells for articular cartilage repair
  • Summary
    • Mesenchymal stem cells (MSCs) have the ability to differentiate into distinctive end-stage cell types, such as those that synthesise specific mesenchymal tissues including cartilage, bone, tendon and muscle. MSCs have a number of advantages over primary chondrocytes for cartilage repair, including their ease of expansion and maintenance of phenotype. It has been shown that MSCs isolated from patients with knee OA show greater chondrogenic capability than primary chondrocytes obtained from articular cartilage biopsies from the same OA joints. However the clinical use of MSCs is restricted by insufficient knowledge of how the environment such cells will experience in vivo will influence the long-term stability of the repair tissue. The objective of this research is to provide a better understanding of how the mechanical loading experienced by MSCs or engineered tissues in vivo will influence their differentiation pathway and the quality and type of tissue they produce. Furthermore we wish to investigate whether the mechanical properties of scaffolds used to provide functional support to implanted cells can be optimised to promote and enhance chondrogenesis of the repair tissue.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2008
  • Date To
    • 2013
  • Title
    • A new constitutive framework to investigate the role of mechanical forces on protein synthesis and organization during differentiation of mesenchymal progenitor cells
  • Summary
    • It is believed that the mechanical environment of mesenchymal stem cells can influence their differentiation pathway. A number of different hypotheses have been proposed which describe how mechanical forces can regulate this pathway. It has been possible to test many of these ideas by encapsulating the hypothesis into an algorithm, and then conducting 'numerical experiments' to determine if the hypotheses on which the algorithm is based can predict realistic patterns of tissue differentiation. It is still unclear as to how the mechanical properties of tissues change during the differentiation process due to changes in protein synthesis, assembly, cross-linking, orientation etc. The hypothesis under investigation here is that mechanical forces regulate protein synthesis and organization during the differentiation of cells of the mesenchymal lineage, and hence the resulting mechanical properties of the differentiating tissue.
  • Funding Agency
    • IRCSET
  • Date From
    • 2008
  • Date To
    • 2012
  • Title
    • Design and development of a novel device to control the fabrication, confined compression and in situ delivery of cell-seeded collagen gel scaffolds
  • Summary
    • Tissue engineering strategies offer a potential solution for cartilage defect repair, however results to date have been mixed. Delivering a functional cell-seeded construct to the defect site would appear to be critical for successful cartilage repair. Recently it has been shown that plastic compression of collagen gel scaffolds leads to significant increase in the mechanical properties of the scaffold. The objective of this project is to develop a hand-held clinical device to control the gelation and levels of confined compression applied to cell-seeded collagen gels prior to implantation. By controlling the rate and magnitude of the confined compression, it is hypothesised that a gradient scaffold with depth dependant mechanical properties similar to normal articular cartilage can be fabricated and delivered directly to the defect site
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2008
  • Date To
    • 2009
  • Title
    • The influence of biophysical stimuli on tissue differentiation and matrix synthesis in vitro.
  • Summary
    • Recent in vitro studies have demonstrated that both chondrogenesis and osteogeneis of bone marrow-derived mesenchymal stem cells (MSCs) can be induced using specific growth factors. Mechanical loading is known to influence the biosynthetic activity of osteoblasts and chondrocytes, however the effects of mechanical stimulation on regulating the differentiation pathway of MSCs remains unclear. The question that this proposal wishes to addresses is whether cartilage and bone like tissues can be selectively engineered using the same scaffold type and the same cell type (marrow-derived MSCs) by varying the mechanical environment of the cells.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2007
  • Date To
    • 2010
  • Title
    • Development of a method to predict which carotid plaques will rupture using Computerised Tomographic Angiography(CTA) and Duplex Ultrasound(US) with Grey-Scale Median imaging, numerical modelling, tissue testing and human serum markers
  • Summary
    • Many atherosclerotic plaques form in arteries, some cause stenosis and symptoms of ischemia, whilst others lie in regions of expansive remodelling unrestricting blood flow. It is these vulnerable plaques that can be prone to sudden rupture and lead to an acute stroke or sudden death without warning. The aim of this project is therefore to identify the key characteristics normally associated with vulnerable carotid plaques, such as geometry and plaque material properties using CTA and Duplex US with GSM imaging techniques. It is then proposed to use these images to generate 3-D realistic numerical models of the vessel to estimate the stresses in the plaque under physiological loading conditions
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2007
  • Date To
    • 2010
  • Title
    • A novel device to control in situ the thermal gelation and concentration of cell-seeded hydrogels
  • Summary
    • It is believed that injuries to cartilage predispose a person to osteoarthritis in later life and eventually to a requirement for joint replacement surgery. Injectable chondrocyte-seeded hydrogels can potentially be used to fill cartilage defects with a functional repair tissue. Ensuring that the hydrogel has the appropriate mechanical properties in situ (e.g. stiffness, permeability, porosity) is critical for successful repair. The objective of this project is to develop a clinical device capable of controlling the hydrogel concentration and the rate of cooling during gelation in situ, which can be used to alter the depth dependant mechanical properties of the construct.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2007
  • Date To
    • 2009
  • Title
    • Mini Stents: A novel stent system consisting of multiple, independent stents delivered from a single device
  • Summary
    • While successful in preventing elastic recoil following balloon angioplasty, stenting results in increased injury and ultimately restenosis in 10-40% of cases. Complication rates are higher in long and tortuous vessels, in many cases due to the inability of a relatively stiff stent to conform to the vessel's curvature. The objective of this project is design a novel stent system that can comply with any vessel wall, regardless of its tortuosity, thereby minimising vessel injury.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2006
  • Date To
    • 2008
  • Title
    • Design and Manufacture of a Novel Bone-Protecting Handheld Distractor.
  • Summary
    • Orthopaedic bone spreaders (distractors) are surgical instruments designed for the distraction and holding apart of segments of bone and are commonly used surgical tool. Existing versions are rigid and non-jointed steel instruments which have a tendency to cut or dig into or otherwise crush or damage bone along their edges or corners, especially when placed between angled or nonparallel surfaces. Our aim is to construct a instrument which is surface conforming and evenly applies its contact stress This is intended as being protective of the pathologically fragile bone of osteoporosis which is specifically vulnerable to the kind of intra-operative damage existing instruments can inflict.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2007
  • Date To
    • 2008
  • Title
    • Computational modelling of in-stent restenosis
  • Summary
    • The major limitation of angioplasty with or without stenting is restenosis of the target vessel. There are a number of possible mechanisms responsible for restenosis, including neointimia formation and negative remodelling due to uncontrolled cell proliferation, migration and matrix synthesis following injury to the vessel wall. Drug-eluting stents have been successful in reducing the incidence of restenosis by targeting some (but not all) of the biological processes contributing to the condition, although even their effectiveness has recently been queried. The objective of this project is to develop a computational model of the biochemical and physical mechanisms responsible for in-stent restenosis.
  • Funding Agency
    • Irish Research Council for Science, Engineering and Technology
  • Date From
    • 2006
  • Date To
    • 2009
  • Title
    • OPTIMIZING THE DESIGN OF PERIPHERAL STENTS USING FINITE ELEMENT MODELLING
  • Summary
    • Peripheral vascular disease (PVD) is a condition in which there is insufficient blood flow through the arms or legs, causing pain, cramping or heaviness in the muscle. Causes of PVD include atherosclerosis, scar tissue and blood clots. In patients with PVD, balloon angioplasty, with or without stenting, may be used to open up a blocked iliac or femoral artery that supplies blood to the leg; however the procedural and long-term success of peripheral stenting has been inferior to coronary stenting. Restenosis rates are high, and technical difficulties have been encountered with delivering these large stents from a balloon catheter. The objective of this project is to use finite element modelling to understand how the design of a peripheral stent influences (i) its deployment from a balloon, and (ii) the stresses developed in the vessel wall, which are known to influence restenosis rates. Ultimately the objective if this project will be to optimise the design of a peripheral stent so that it can be deployed successfully from a balloon catheter and will minimise the stresses generated in the vessel wall.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2005
  • Date To
    • 2007

Keywords

Arthritis; Bioengineering; Biomaterials; Biomechanics; Biomechanics, Biomedical Engineering; Biomolecules, Bioplastics, Biopolymers; Bioreactors; Cardiovascular System; Computational Biology; Computer-Aided Engineering; Mathematical modelling; Mechanical Engineering; Mechanics; Medical Devices Engineering; Solid Mechanics; Stem Cell; STEM-CELLS; STENTS; Tissue Engineering

Recognition

Awards and Honours

Norman Gamble Award in Otology 2002

Hewlett Packard Prize 1999

Science Foundation Ireland President of Ireland Young Researcher Award (PIYRA) 2008

Fulbright Award 2009

Fellow of Trinity College Dublin 2010

European Research Council Starter Award, 2010

Senior author of paper awarded the 2012 Perren Award of the European Society of Biomechanics for best scientific paper (presented at 18th Congress of the ESB). 2012

European Research Council Consolidator Award 2015