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David Hoey
Associate Professor, Mechanical & Manuf. Eng

Biography

Dr. David Hoey is an Associate Professor in Biomedical Engineering within the Department of Mechanical and Manufacturing Engineering and PI within the Trinity Centre for Bioengineering in Trinity College Dublin (TCD). Dr. Hoey leads a multidisciplinary experimental mechanobiology research group where his goal is to integrate engineering mechanics into the understanding of the molecular basis of physiology and disease. Dr. Hoey's research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, he is focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new therapeutics that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis. In 2009 Dr. Hoey received his PhD in Bioengineering from the Trinity Centre for Bioengineering and went on to complete postdoctoral fellowships in Columbia University in the US and the Royal College of Surgeons in Ireland under the Marie-Curie/IRCSET programme. In 2012 he joined the University of Limerick as a Lecturer and was awarded the European Research Council Starting Grant in 2013 to explore the role the primary cilium in stem cell mechanobiology in bone and has recently returned to TCD in 2015 as Associate Professor to continue this work.

Publications and Further Research Outputs

Peer-Reviewed Publications

Flanagan AM, Stavenschi E, Basavaraju S, Gaboriau D, Hoey DA, Morrison CG, Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification., 2017 Journal Article, 2017

Labour MN, Riffault M, Christensen ST, Hoey DA, TGFß1 - induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner., 2016 Journal Article, 2016

O'Connor Mooney R, Davis NF, Hoey D, Hogan L, McGloughlin TM, Walsh MT, On the Automatic Decellularisation of Porcine Aortae: A Repeatability Study Using a Non-Enzymatic Approach., 2016 Journal Article, 2016

Corrigan M, Lee K, Labour M, Jacobs C, Hoey D, Fluid flow-induced bending of the primary cilium triggers a distinct intraciliary calcium flux in mesenchymal stem cells., 2015 Journal Article, 2015

Chen JC, Hoey DA, Chua M, Bellon R, Jacobs CR, Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015 Journal Article, 2015 TARA - Full Text DOI

Labour M, Christensen S, Hoey D, TGFß1 Signalling in human mesenchymal stem cells is regulated by the primary cilium., 2015 Journal Article, 2015

Brady RT, O'Brien FJ, Hoey DA, Mechanically stimulated bone cells secrete paracrine factors that regulate osteoprogenitor recruitment, proliferation, and differentiation., Biochemical and biophysical research communications, 459, (1), 2015, p118 - 123 Journal Article, 2015 TARA - Full Text

Espinha L., Espinha L., Hoey D., Hoey D., Fernandes P., Rodrigues H., Jacobs C., Oscillatory fluid flow influences primary cilia and microtubule mechanics, Cytoskeleton, 71, (7), 2014, p435 - 445 Journal Article, 2014 TARA - Full Text DOI

Downs M., Nguyen A., Herzog F., Hoey D., Hoey D., Hoey D., Jacobs C., An experimental and computational analysis of primary cilia deflection under fluid flow, Computer Methods in Biomechanics and Biomedical Engineering, 17, (1), 2014, p2 - 10 Journal Article, 2014 DOI

Browne L., O'Callaghan S., Hoey D., Griffin P., McGloughlin T., Walsh M., Correlation of Hemodynamic Parameters to Endothelial Cell Proliferation in an End to Side Anastomosis, Cardiovascular Engineering and Technology, 5, (1), 2014, p110 - 118 Journal Article, 2014 DOI

Lee K., Hoey D., Hoey D., Hoey D., Spasic M., Spasic M., Tang T., Tang T., Hammond H., Hammond H., Jacobs C., Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo, FASEB Journal, 28, (3), 2014, p1157 - 1165 Journal Article, 2014 DOI

Jacobs C, Downs M, Nguyen A, Herzog F, Hoey D, Mechanical behavior of primary cilia., 2012 Journal Article, 2012

Hoey D., Hoey D., Hoey D., Chen J., Jacobs C., The primary cilium as a novel extracellular sensor in bone, Frontiers in Endocrinology, 3, (JUN), 2012 Journal Article, 2012 DOI

Hoey, D.A., Downs, M.E., Jacobs, C.R., The mechanics of the primary cilium: An intricate structure with complex function, Journal of Biomechanics, 45, (1), 2012, p17-26 Journal Article, 2012

Hoey D., Hoey D., Hoey D., Tormey S., Ramcharan S., O'Brien F., O'Brien F., Jacobs C., Primary cilia-mediated mechanotransduction in human mesenchymal stem cells, Stem Cells, 30, (11), 2012, p2561-2570 Journal Article, 2012 DOI

Hoey, D.A., Kelly, D.J., Jacobs, C.R., A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 412, (1), 2011, p182-187 Journal Article, 2011 TARA - Full Text

Grande D., Shah N., Catanzano A., Nelson F., Hoey D., Hoey D., Jacobs C., On the horizon from the ORS, Journal of the American Academy of Orthopaedic Surgeons, 19, (1), 2011, p59-62 Journal Article, 2011

Hoey, D.A., Jacobs, C.R., Oscillatory fluid flow affects the osteogenic differentiation of human bone marrow stromal cells in a primary cilium dependent manner, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p331-332 Journal Article, 2011

Lee, K.L., Hoey, D.A., Jacobs, C.R., Primary cilia-mediated mechanotransduction in bone, Clinical Reviews in Bone and Mineral Metabolism, 8, (4), 2010, p201-212 Journal Article, 2010

Herzog, F.A., Geraedts, J., Hoey, D., Jacobs, C.R., A mathematical approach to study the bending behavior of the primary cilium, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010, 2010 Journal Article, 2010

Hoey D and Taylor D, The effect of mixing technique on fatigue of bone cement when stress concentrations are present., International Journal of Nano and Biomaterials, 3, 2010, p36 - 48 Journal Article, 2010 DOI

Hoey, D., Carette, D., O'Reilly, P., Taylor, D., The role of stress concentrations in the bone cement mantle, Proceedings of the ASME Summer Bioengineering Conference, SBC2008, (PART A), 2009, p463-464 Journal Article, 2009

Hoey D and Taylor D, Quantitative analysis of the effect of porosity on the fatigue strength of bone cement., Acta Biomaterialia, 5, 2009, p719 - 726 Journal Article, 2009 DOI

Hoey D and Taylor D, Comparison of the fatigue behaviour of two different forms of PMMA, Fatigue and Fracture of Engineering Materials and Structures, 32, 2009, p261 - 269 Journal Article, 2009 DOI

Hoey D and Taylor D, Statistical distribution of the fatigue strength of porous bone cement. , Biomaterials, 30, 2009, p6309 - 6317 Journal Article, 2009 DOI

Taylor D and Hoey D, High cycle fatigue of welded joints: the TCD experience, International Journal of Fatigue, 31, 2009, p20 - 27 Journal Article, 2009 DOI

Hoey D and Taylor D , Fatigue in porous PMMA: the effect of stress concentrations, International Journal of Fatigue, 30, 2008, p989 - 995 Journal Article, 2008

Hoey, D., O'Reilly, P., Taylor, D., Fatigue in PMMA: The effect of notches and pores predicted using the TCD, 17th European Conference on Fracture 2008: Multilevel Approach to Fracture of Materials, Components and Structures, 2, 2008, p1570-1575 Journal Article, 2008

Taylor, D., Hoey, D., Sanz, L., O'Reilly, P., Fracture and fatigue of bone and bone cement: The critical distance approach, Fracture of Nano and Engineering Materials and Structures - Proceedings of the 16th European Conference of Fracture, 2006, p1025-1026 Journal Article, 2006

Research Expertise

Description

Orthopaedic Biomechanics and Mechanobiology Mechanotransduction mechanisms Biomaterials Primary Cilia Cancer Mechanobiology

Projects

  • Title
    • Primary Cilium Mediated Mesenchymal Stem Cell Mechanobiology in Bone
  • Summary
    • Every 30 seconds a person suffers an osteoporosis-related bone fracture in the EU, resulting in significant morbidity, mortality, and health-care costs estimated at €36 billion annually. Current therapeutics target bone resorbing osteoclasts, but these are associated with severe side effects. Osteoporosis arises when mesenchymal stem cells (MSC) fail to produce sufficient numbers of bone forming osteoblasts. A key regulator of MSC behaviour is physical loading, yet the mechanisms by which MSCs sense and respond to changes in their mechanical environment are virtually unknown. Primary cilia are nearly ubiquitous 'antennae-like' cellular organelles that have very recently emerged as extracellular mechano/chemo-sensors and thus, are strong candidates to play an important role in regulating MSC responses in bone. However, to date, research on the stem cell primary cilium is almost non-existent. Therefore, the objective of this research program is to determine the role of the understudied primary cilium and associated molecular components in the osteogenic differentiation and recruitment of human MSCs in loading-induced bone adaptation. This will be achieved through ground breaking in vitro and in vivo techniques developed by the applicant. The knowledge generated in this proposal will represent a profound advance in our understanding of stem cell mechanobiology. In particular, the identification of the cilium and associated molecules as central to stem cell behaviour will lead to the direct manipulation of MSCs via novel cilia-targeted therapeutics that mimic the regenerative influence of loading at a molecular level. These novel therapeutics would therefore target bone formation rather than resorption, providing an innovative alternative path to treatment, resulting in an improved supply of bone forming cells, preventing osteoporosis. Furthermore, these novel therapeutics will be incorporated into biomaterials generating novel bioactive osteoinductive scaffolds. These advances will not only improve quality of life for the patient but will significantly reduce the financial burden of bone loss diseases in the EU.
  • Funding Agency
    • European Research Council
  • Date From
    • 01/11/2013
  • Date To
    • 31/10/2018
  • Title
    • Osteoprogenitor Regulation in Loading-induced Bone Formation: An Alternative Approach to Treating Osteoporosis
  • Summary
    • Every 30 seconds a person suffers an osteoporosis-related bone fracture, resulting in significant morbidity, mortality, and health-care costs estimated at 36billion euro annually. Current therapeutics target osteoclasts but are associated with severe side effects. Osteoporosis arises when stem cells (MSCs) fail to produce sufficient numbers of osteoblasts. A key regulator of MSC behaviour is loading, yet the mechanisms by which MSCs proliferate, differentiate and are recruited to sites of loading to replace exhausted osteoblasts remain elusive. Osteocytes are ideally numbered and positioned to be sensors and regulators of bone formation. However research on osteocyte-MSC signalling is almost non-existent. Therefore the objective of this research project is to determine the role of the osteocyte and associated signalling mechanisms in regulating MSC contributions to bone formation and to develop novel 'Bone-on-a-Chip' microfluidic platforms for the validation of novel anabolic therapeutics for osteoporosis.
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2014
  • Date To
    • 2018

Keywords

BIOMATERIALS; BIOMECHANICS; Biomechanics, Biomedical Engineering; BONE ABNORMALITIES; BONE ADAPTATION; BONE CEMENT; BONE MASS; BONE METASTASIS; BONE REGENERATION; bone remodelling and repair; CELL BIOMECHANICS; MECHANOBIOLOGY; MESENCHYMAL STEM CELLS; Promotion of Bone Health throgh Exercise; Stem Cell Biology

Recognition

Awards and Honours

Senior author of paper awarded 1st prize at the Sir Bernard Crossland Symposium (Kian Eichholz) 2016

Marie-Skłodowska Curie COFUND Excellence award 2015

University of Limerick Award for Research Excellence (Early Career) 2014

European Research Council Starting Grant 2013

Memberships

Engineers Ireland (Treasurer of the Biomedical Division) 2006 – present

Orthopedic Research Society 2010 – present

Marie-Curie Fellow Association 2015 – present