Biography
John J. Walsh, BA (Mod.), PhD (TCD), is an Associate Professor of Pharmacognosy and Associate Director of the NatPro Centre for Natural Product Research in Trinity College Dublin. A particular theme of his research is the evaluation of plant-based metabolites for potential use in the treatment of inflammatory conditions, microbial and insect-related infections, allergies and cancer. In parallel, he also runs drug design based projects with particular emphasis on the design, synthesis and evaluation of hybrid-based compounds and designed multiple ligands as potential therapies for both malaria and cancer. As Senior Author he has published widely across many of the leading journals in his field. including Journal of Natural Products, European Journal of Medicinal Chemistry, British Journal of Pharmacology, Bioorganic and Medicinal Chemistry, Angiogenesis, Current Pharmaceutical Design, Pharmaceutical Research, Current Medicinal Chemistry, Pharmaceutics and Chemical Communications. Funding for his research has been secured from Enterprise Ireland, Cancer Research Ireland, Research Ireland, Higher Education Authority and Department of Justice, Ireland. As principal supervisor he has supervised 20 PhD and 4 MSc students to completion. He is a very strong advocate of research-led teaching and has published eight papers in the Journal of Chemical Education on miniaturised and sustainable methods for the isolation of medicinally important natural products. He is a former Director of Undergraduate Teaching and Learning in the School of Pharmacy and Pharmaceutical Sciences and is currently a member of Committee 13B (Phytochemistry) of the European Pharmacopoeia.
Publications and Further Research Outputs
Peer-Reviewed Publications
Kavita Gadar; Maria Pigott; Cillian Jacques Gately; Ismael Obaidi; Shipra Nagar; John J. Walsh; Helen Sheridan; Ronan R McCarthy, Bogland plant Tormentil inhibits multidrug-resistant pathogen growth and potentiates antibiotics by disrupting iron homeostasis, Microbiology (Reading), 172, (3), 2026, p1 - 14
Mark J. Lyons, Brendan Twamley, John J. Walsh, CCDC 2554447: Experimental Crystal Structure Determination, Cambridge Crystallographic Data Centre, 2026
Whyms SE, Sheridan H, Walsh JJ, Design Considerations for Essential Oil Formulations: Emulsification, Encapsulation and Stabilisation Strategies, Pharmaceutics, 18, (8), 2026, p953 - 995
Khadijah Jabal, Phytochemical studies on Lusitanian heath species and their effects on angiogenesis and melanogenesis (PhD Thesis), Trinity College Dublin, 2026
Ronan R. McCarthy, Kavita Gadar, John Walsh, Wildflower once used to treat wounds and sore throats shows promise in fighting dangerous superbugs, The Conversation, 2026
Mark Lyons, Optimisation of analytical, biological, and synthetic methods relevant to the pre-clinical development of orellanine as a targeted therapeutic for renal cell carcinoma (PhD Thesis), Trinity College Dublin, 2026
Nagar, S., Pigott, M., Kukula-Koch, W., Sheridan, H., & Walsh, J., NMR Data of Lichenic Acids From Irish Cladonia Portentosa, nmrXiv, 2026
Erol, Ã-zlem and Nagar, Shipra and Selo, Mohammed Ali and Obaidi, Ismael and Walsh, John J. and Sheridan, Helen and Choi, Young Hae, Identification of anti-inflammatory and antimicrobial compounds from leaves and rhizome of Iris pseudacorus collected in Ireland bogland using chemical profiling techniques, Fitoterapia, 185, 2025
Minchao Guo, Muhammad Waleed Baig, Shane Carney, Ferdia O'Malley, Joshua Odidison, Amirul Helmi Idris, Stacey Li Hi Shing, John O'Brien, James W. Barlow, John Walsh, Studies on the Isolation and Structure Elucidation of Berberine, (")-ß-Hydrastine, and Jatrorrhizine from Goldenseal Root (Hydrastis canadensis L.) and Mahonia x media `Winter Sun" Stem Bark, Journal of Chemical Education, 102, (4), 2025, p1643 - 1650, p1643-1650
, A study on the antiproliferative activity of the triterpenoid constituents in Erica erigena, 69, 2025, pp103623-103623
Jabal, Khadijah A. and Pigott, Maria and Sheridan, Helen and Walsh, John J., Mediterranean Basin Erica Species: Traditional Uses, Phytochemistry and Pharmacological Properties, Molecules, 30, (12), 2025
MJ Lyons, C Ehrhardt, JJ Walsh, Orellanine: From fungal origins to a future cancer treatment, J Nat Prod, 86, (6), 2023, p620-1631
Quanxiang Yan, Tao Zhang, Christine O'Connor, James W. Barlow, John Walsh, Gaia Scalabrino, Feng Xu, Helen Sheridan, The biological responses of vitamin K2: A comprehensive review, Food Science & Nutrition, 00, 2023, p1 - 23
Gary Stack, Stereoselective synthesis of novel tubulin inhibitors with diverse functionality for integration into molecular conjugates and designed multiple ligands (Ph.D. Thesis), Trinity College Dublin, 2023
(ed.), A study on the triterpenoid constituents in Erica Erigena, 89, (14), 2023, 1326 - 1326 p, 1326-1326 p
Herng Mak, John Walsh, Short Lecture Where nature's toxins meet biologics: digital teaching of antibody-drug conjugates", 89, (14), 2023, pp1300 - 1300, pp1300-1300
Anwar N, Khan A, Shah M, Walsh JJ, Saleem S, Anwar Z, Aslam S, Irshad M., Hybridization of green synthesized silver nanoparticles with poly(ethylene glycol) methacrylate and their biomedical applications., PeerJ , (10), 2022, p1 - 28
Collyer, Samuel E., Gary D. Stack, and John J. Walsh, Selective Delivery of Clinically Approved Tubulin Binding Agents through Covalent Conjugation to an Active Targeting Moiety, CURRENT MEDICINAL CHEMISTRY, 29, (31), 2022, p5179 - 5211
Ryan TJ, Ryder SA, D'Arcy DM, Quigley JM, Ng NN, Ong WQ, Tey ZH, O'Dwyer M, Walsh JJ., Development of Professional Attributes through Integration of Science and Practice at First-Year Pharmacy Level, Pharmacy, 2021
Natasha Anwar, Abbas Khan, Mohib Shah, John Walsh, Zeeshan Anwar, Hybridization of Gold Nanoparticles with Poly(ethylene glycol) Methacrylate and Their Biomedical Applications, Russian Journal of Physical Chemistry A, 95, (13), 2021, p2619 - 2631, p2619-2631
Ijaz S, Shoaib Khan HM, Anwar Z, Talbot B, Walsh JJ, HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential, Biomedicine & Pharmacotherapy, 109, 2019, p865 - 875
Ryan, T.J.; Grimes, T.; Henman, M.C.; Sheachnasaigh, E.N.; O'Dwyer, M.; Roche, C.; Ryder, S.A.; Sasse, A.; Walsh, J.J. & D'Arcy, D.M, Design and Implementation of an Integrated Competency-Focused Pharmacy Programme: A Case Report., Pharmacy, 7, (3), 2019
Zeeshan Anwar, Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties, Trinity College Dublin, 2019
Denise Ropero, Phytochemical studies on Choisya x dewitteana 'Aztec Pearl', 2018
(ed.), Aromatic Substitution Reaction of Ergothioneine; a Novel Mechanism of Xenobiotic Deactivation, 31, (S1), 2017
, Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo, 30, (S1), 2016
Zhang T, Finn D.F, Barlow J.W, Walsh J.J, Mast cell stabilisers, European Journal of Pharmacology, 778, 2016, p158 - 168
(ed.), OCTN1"Mediated Ergothioneine Uptake Protects Lung Epithelial Cells From Tobacco Smoke"Induced Damage, 29, (S1), 2015
Linker technologies and release mechanisms for antibody-drug conjugates in, editor(s)Professor Norbert Sewald , Optimizing antibody-drug conjugates for targeted delivery of therapeutics, Future press, 2015, pp40 - 55, [John J. Walsh and Gary D. Stack ]
G. Sturman(ed.), NOVEL MAST CELL-STABILISING ALCOHOLDERIVATIVES OF 3,4 DIHYDRONAPHTHALEN-1(2H)-ONE and 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-ONE, Inflammation Research, Malaga, Spain, 64, (Suppl 1), May 6-9, 2015, 2015, 15 - 15 p
Brian Moran, The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents (PhD Thesis), Trinity College Dublin, 2015
Egan M, Connors E.M, Anwar Z, Walsh J.J, Nature's Treatment for Irritable Bowel Syndrome: Studies on the Isolation of (-)-Menthol from Peppermint Oil and Its Conversion to (-)-Menthyl Acetate, Journal of Chemical Education, 92, (10), 2015, p1736 - 1740
Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug, Pharmaceuticals, 7, (6), 2014, p676 - 694
Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion, Pharmaceuticals, 7, (5), 2014, p595 - 620
Bopha Chrea, Juliette A. O'Connell, Orlando Silkstone-Carter, John O'Brien, and John J. Walsh, Nature's Antidepressant for Mild to Moderate Depression: Isolation and Spectral Characterization of Hyperforin from a Standardized Extract of St. John's Wort (Hypericum perforatum), Journal of Chemical Education, 91, (3), 2014, p440 - 442
Finn, D.F., Walsh, J.J., Twenty-first century mast cell stabilizers, British Journal of Pharmacology, 170, (1), 2013, p23-37
Prokopiou EM, Ryder SA, Walsh JJ, Tumour vasculature targeting agents in hybrid/conjugate drugs., Angiogenesis, 16, (3), 2013, p503 - 524
Emma L. Walsh, Siobhan Ashe, and John J. Walsh, Nature's Migraine Treatment: Isolation and Structure Elucidation of Parthenolide from Tanacetum parthenium, Journal of Chemical Education, 89, 2012, p134 - 137
Gary D. Stack and John J. Walsh, Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation., Pharmaceutical Research, 29, (11), 2012, p2972 - 2984
Anne-Marie Carroll, David J. Kavanagh, Fiona P. McGovern, Joe W. Reilly, and John J. Walsh, Nature's Chiral Catalyst and Anti-Malarial Agent: Isolation and Structure Elucidation of Cinchonine and Quinine from Cinchona calisaya, Journal of Chemical Education, 89, 2012, p1578 - 1581
Maisarah Mohd Nazri, Farah D. Samat, Pierce V. Kavanagh, and John J. Walsh, Nature's Cholesterol-Lowering Drug: Isolation and Structure Elucidation of Lovastatin from Red Yeast Rice-Containing Dietary Supplements, Journal of Chemical Education, 89, 2012, p138 - 140
Carroll, A.-M., Kavanagh, D.J., McGovern, F.P., Reilly, J.W., Walsh, J.J., Natures chiral catalyst and anti-malarial agent: Isolation and structure elucidation of cinchonine and quinine from cinchona calisaya, Journal of Chemical Education, 89, (12), 2012, p1578-1581
James W. Barlow, Tao Zhang, Orla Woods, Adam J. Byrne, John Walsh, Novel Mast Cell-Stabilising Amine Derivatives of 3,4-Dihydronaphthalen-1(2H)-one and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-one, Medicinal Chemistry, 7, (3), 2011, p213 - 223, p213-223
James W. Barlow, Aengus P. McHugh, Orla Woods, John J. Walsh, Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds, European Journal of Medicinal Chemistry, 46, (5), 2011, p1545-1554
Adam J. Byrne, James W. Barlow, John J. Walsh, Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent, Bioorganic & Medicinal Chemistry Letters, 21, (4), 2011, p1191-1194
Barlow JW, Walsh JJ., Synthesis and evaluation of dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity., European Journal of Medicinal Chemistry, 45, (1), 2010, p25 - 37
Breen EC and Walsh JJ, Tubulin-targeting agents in hybrid drugs., Current Medicinal Chemistry, 17, (7), 2010, p609 - 639
O'Byrne PM, Williams R, Walsh JJ, Gilmer JF., The aqueous stability of bupropion, Journal of Pharmaceutical and Biomedical Analysis, 53, (3), 2010, p376 - 381
Ellen C. Breen, John Walsh, Tubulin-Targeting Agents in Hybrid Drugs, Current Medicinal Chemistry, 17, (7), 2010, p609 - 639, p609-639
Catherine M. Halpin, Ciara Reilly, and John J. Walsh, Nature's Anti-Alzheimer's Drug: Isolation and Structure Elucidation of Galantamine from Leucojum aestivum, Journal of Chemical Education, 87 , (11), 2010, p1242 - 1243
Walsh JJ and Bell A, Hybrid Drugs for Malaria, Current Pharmaceutical Design, 15(25), 2009, p2970-85
Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930
Sheridan H, Walsh JJ, Jordan M, Cogan C, Frankish N., A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties., European Journal of Medicinal Chemistry, 44, (12), 2009, p5018 - 5022
Sheridan, H. Walsh, J. J. Jordan, M. Cogan, C. Frankish, N, A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties, Eur J Med Chem, 44, (12), 2009, p5018-22
Sheridan H, Butterly S, Walsh JJ, Cogan C, Jordan M, Nolan O, Frankish N, Synthesis and pharmacological activity of aminoindanone dimers and related compounds, Bioorganic and Medicinal Chemistry, 16, (1), 2008, p248 - 254
Barlow JW, Walsh JJ, Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds, European Journal of Medicinal Chemistry, 43, (12), 2008, p2891 - 2900
Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A., A Novel Artemisinin-Quinine Hybrid with Potent Antimalarial Activity., Bioorganic and Medicinal Chemistry Letters, 17, (13), 2007, p3599 - 3602
Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A, A novel artemisinin-quinine hybrid with potent antimalarial activity, Bioorganic and Medicinal Chemistry Letters, 17, (13), 2007, p3599 - 3602
Douglas RH, Muldowney CA, Mohamed R, Keohane F, Shanahan C, Kavanagh PV, Walsh JJ, Detection and quantification of valerenic acid in commercially available valerian products, Journal of Chemical Education, 84, (5), 2007, p829 - 831
Gillian Hudson, Design, synthesis and evaluation of novel tumour vasculature-targeting agents (PhD Thesis), 2007
Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A., A novel artemisinin-quinine hybrid with antimalarial activity., 11th International Congress of Parasitology, Glasgow, Aug, 2006
Walsh JJ, Treacy S, Dunne A, Kavanagh PV, A Simple Method For The Identification of Common Herbal/Alternative health products by Gas Chromatography/Mass Spectrometry, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp334-
Kavanagh PV, McCarthy S, Walsh JJ, Identification and quantitation of lovastatin in red yeast rice, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp335-
Byrne A, Walsh JJ, Studies on the Mast cell stabilising properties of plant extracts with reputed anti-inflammatory activity, 34th meeting of the European histamine research society, Bled, Slovenia, 2005 May 11-14, 2005, pp7-
White M, Walsh JJ., Sodium Azide: A mild and selective deprotecting reagent for use in the synthesis of novel inhibitors of endothelial cell proliferation, Fifth interdisciplinary euroconference on angiogenesis, Sitges, Spain , May 27-30, 2005, pp114-
Screening for aminopeptidase inhibitors using silica gel thin layer chromatography, Hudson GJ, Ryan EP, Walsh JJ, British Microcirculation Society, 41st Scientific meeting and symposium: Tumour microcirculation: Development and Therapeutic targets, Sheffield, Apr 5-6, 2004, pp37-
A.L. Simplício, J.F. Gilmer, N. Frankish, H. Sheridan, J.J. Walsh and J.M. Clancy, Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1-2), 2004, p233 - 238
Simplício AL, Gilmer JF, Frankish N, Sheridan H, Walsh JJ, Clancy JM., Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1/2), 2004, p233 - 238
Doyle AM, Reilly J, Murphy N, Kavanagh PV, O'Brien JE, Walsh MS, Walsh JJ, Nature's sedative: Isolation and structural elucidation of valtrate from Centranthus ruber, Journal Of Chemical Education, 81, (10), 2004, p1486 - 1487
Byrne A, Donnelly C, Mills C, Walsh JJ, A study on the mast cell stabilising properties of Sargentodoxa cuneata, 33rd annual meeting of theEuropean histamine research society, Düsseldorf / Köln, Germany, Apr 28-May2, 2004, pp29-
Mills C, Cleary BJ, Gilmer JF, Walsh JJ, Inhibition of acetylcholinesterase by Tea Tree oil, Journal Of Pharmacy and Pharmacology, 56, (3), 2004, p375 - 379
Walsh JJ, McCormack EM, Shah R, Endothelium as a target in the design of novel tumour vasculature targeting agents, Anticancer Research: Special edition, 24, 2004, p527 - 528
Richard Shah, The design and synthesis of novel inhibitors of tubulin polymerisation (Ph.D. Thesis), 2003
Cunningham D, Grayson DH, McArdle P, Walsh JJ, The bromination of (-)-camphorquinone, Tetrahedron-Asymmetry, 14, (9), 2003, p1197 - 1200
Emmet McCormack, Design, synthesis and in vitro evaluation of novel anti-cancer compounds (PhD Thesis), 2003
Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752
Walsh JJ, Frankish NF, Sheridan H, Byrne W, Jordan M, Indane compounds and their pharmaceutical use, 2002, US6433021
Carolan JC, Hook ILI, Walsh JJ, Hodkinson TR, Using AFLP markers for species differentiation and assessment of genetic variability of in vitro-cultured Papaver bracteatum (section Oxytona), In Vitro Cellular & Developmental Biology-Plant, 38, (3), 2002, p300 - 307
Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2001, US6297399
Walsh JJ, Frankish NF, Sheridan H, Byrne W. Farrell R, Indane dimer compounds and their pharmaceutical use, 2001, US6300376
Walsh JJ, Walsh MS, Ni Bhrangain S, Kavanagh PV and Feely J, Red Valerian-Nature's Sedative, Irish Journal of Medical Science, 168, (141), 1999, p143-
Comey N, Hook I, Sheridan H, Walsh J, James P., Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl-4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal of Natural Products., 60, (2), 1997, p148 - 148-149
Walsh JJ, Hook I, Kavanagh P, Reininger R., Naphthoquinone production by cultures of cape sundew (Drosera capensis), Pharmacy/Pharmacoloy Letters, 7, 1997, p93 - 95
Comey N, Hook I, Sheridan H, Walsh J. , Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl - 4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal Of Natural Products (Lloydia) , 60, (2), 1997, p148-149
Davis AP, Walsh JJ., Steroid-based receptors with tunable cavities; Stepwise and direct syntheses of a C-3-symmetrical prototype, Chemical Communications, 1996, p449 - 451
Davis AP, Menzer S, Walsh JJ. , Steroid-based receptors with tunable cavities; A series of polyhydroxylated macrocycles of varying size and flexibility, Chemical Communications , 1996, p453 - 456
Davis AP, Walsh JJ, Amide bond formation via pentafluorothiophenyl active esters, Tetrahedron Letters, 35, (27), 1994, p4865 - 4868
Non-Peer-Reviewed Publications
Whyms SE, Nagar S, Luker HA, Lopez AD, Pigott M, Hodkinson TR, Sheridan H, Hansen IA & Walsh JJ, Repellent activity against Aedes aegypti and metabolomic profiling of Myrica gale L. essential oils from Irish boglands, Scientific Reports, 2026, phttps://doi.org/10.1038/s41598
Samuel Collyer, Design and Synthesis of Potent and Selective Anticancer Compounds Targeting Tubulin Polymerisation and Aminopeptidase N (Ph.D. Thesis), 2025
O'Dwyer M, Ryan T, Ryder S, D'Arcy DM, Walsh J. , Innovative Development and Evaluation of Professional Attributes through Integration of Science and Practice at First Year Pharmacy Level , Irish Network of Healthcare Educators Conference, TBSI, Trinity College Dublin, Dublin, Ireland , February 2020, 2020
CG Clerkin, M Matzinger, MA Selo, BN Talbot, JJ Walsh, C Ehrhardt, Nucleophilic substitution reactions of ergothioneine might be a novel xenobiotic deactivation mechanism, 32nd Annual Meeting of the Japanese Society for the Study of Xenobiotics, Tokyo, Japan, 29/11-01/12/2017, 2017
C Ehrhardt, S Nickel, MA Selo, CG Clerkin, JJ Salomon, B Talbot, JJ Walsh, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, FASEB J, Experimental Biology Meeting 2015, Boston, MA, 28/03-01/04/2015, 29, 2015, pp970.7
Elaine Breen, The design, synthesis and preliminary evaluation of prodrugs and hybrid drugs with tubulin polymerisation inhibitory activity and anti-proliferative activity (Ph.D. Thesis), 2013
Ekatherine M. Prokopiou, Preclinical evaluation of novel tumour vasculature disrupting agents (Ph.D. Thesis), 2013
Adrian Coogan, Design and synthesis of tubulin-binding agents, and their incorporation into novel dual-acting hybrid molecules targeting the tumour vasculature (Ph.D. Thesis), 2013
Deirdre Finn, Studies on the design, synthesis and stability of novel anti-allergy agents, 2012
Tao Zhang, The synthesis of novel mast cell stabilisers from benzocycloalkanones (Ph.D. Thesis)), Trinity College Dublin, 2010
Paul O'Byrne, Pharmaceutical stability and prodrug studies on the antidepressant bupropion (Ph.D Thesis), 2010
James Barlow, Synthesis and pharmacological studies on a novel series of mast cell-stabilising tetrahydronaphthalenes and related compounds (Ph.D. Thesis), 2003
Neil Frankish, Helen Sheridan, John Walsh, Michael Jordan,, 'Indane compounds and their pharmaceutical use', N/A, US 6,433,021 B1, 2002, 2 September 2026, Venantius Limited, Dublin
Research Expertise
Description
My research is multidisciplinary, spanning pharmacognosy, chemical/pharmacological sciences, and educational research. This breadth is reflected in my publications as Senior Author, including papers in Chemical Communications, European Journal of Medicinal Chemistry, Current Pharmaceutical Design, Current Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Scientific Reports, Journal of Natural Products, European Journal of Pharmacology, British Journal of Pharmacology, Angiogenesis, Pharmaceutical Research, and Pharmaceutics, as well as in Journal of Chemical Education and Pharmacy . To date, funding for my research has been secured from Enterprise Ireland, Cancer Research Ireland, Research Ireland, the Irish Research Council for Science, Engineering and Technology, the Higher Education Authority, and the Department of Justice, Ireland. Support has also included funded PhD studentships from students" home institutions. As primary/sole supervisor, I have mentored and trained 19 PhD students to completion and a further student as secondary supervisor. In addition, I supervised five Pakistani-registered PhD students who completed substantial parts of their research during a six-month secondment to my laboratory. For the next four years, my research is supported through funding secured from Research Ireland. Looking ahead, herbal medicinal plant production must increasingly shift from wild cultivation to plant biotechnological production, as climate change is already destabilizing both supply and quality. This is evident from my work with the European Pharmacopoeia, where specifications for certain plant-based medicines needed to be revised to ensure regulatory compliance. In this regard, I am collaborating with the Luxembourg Institute of Science and Technology (LIST, https://www.list.lu/) and other EU partners on large-scale (300 L) biotechnological production of Irish medicinal and agriculturally important plants. We are in the final stages, with a 17 September deadline, of submitting a Horizon grant application titled "Forging solutions for agricultural applications through scalable plant cell factories." The requested total budget is €4 million, including €574,000 allocated to my work packages.Projects
- Title
- Pre-clinical Development of Novel Anti-allergic Compounds
- Summary
- The work involved synthesis of lead compounds and evaluation of their effects in vitro and in vivo against passive cutaneous anaphylaxis.
- Funding Agency
- Enterprise Ireland
- Date From
- Oct 2004
- Date To
- Mar 2009
- Title
- Design of Tumour Homing Vasculature Targeting Agents
- Summary
- The project involved the synthesis of designed multiple ligands with homing properties to tumour vasculature.
- Funding Agency
- Irish Research Council for Science Engineering and Technology
- Date From
- 01-10-2008
- Date To
- 30-09-2011
- Title
- Design of Hybrid-based Tumour Homing Anti-angiogenesis Agents
- Summary
- The purpose of this work was to design, synthesise and evaluate the homing properties of hybrid-based anti cancer compounds.
- Funding Agency
- Irish Research Council for Science Engineering and Technology
- Date From
- 01-10-2008
- Date To
- 30-09-2011
- Title
- Studies on Novel Mast Cell Stabilising Compounds
- Summary
- The project involved in vitro and in vivo studies on novel mast cell stabilising compounds.
- Funding Agency
- Irish Research Council For Science Engineering and Technology
- Date From
- 01-10-2008
- Date To
- 30-09-2009
- Title
- Synthesis and evaluation of tunable cyclolactams for antimalarial therapy
- Summary
- The project involved the synthesis of peptide-based tunable cyclolactams and their in vitro evaluation against Plasmodium falciparum. In collaboration with Dr Angus Bell, Department of Microbiology, TCD.
- Funding Agency
- Enterprise Ireland
- Date From
- Jan. 2004
- Date To
- Apr. 2005
- Title
- Endothelium as a Target in the Design of Novel Anti-cancer agents
- Summary
- The purpose of the funding was to design novel inhibitors of tumour- angiogenesis and vascularisation.
- Funding Agency
- Cancer Research Ireland
- Date From
- Oct. 2003
- Date To
- Sept. 2006
- Title
- Pre-clinical Development of Novel Anti-allergic Compounds
- Summary
- Allergy Research: IF/2001/014: Research Innovation Fund.
- Funding Agency
- Enterprise Ireland
- Date From
- Dec 2001
- Date To
- Apr. 2004
- Title
- Discovery of Novel Anti-cancer compounds
- Summary
- HE/98/249: Applied Research Grant
- Funding Agency
- Enterprise Ireland
- Date From
- Oct. 1998
- Date To
- Mar. 2001
- Title
- Appraisal of Wound Healing Potentials of Bergenia purpurascens in Photodynamic therapy (PDT): A Combined Chemical, In Vitro and In Vivo Approach
- Summary
- The proposal aims to evaluate the potential of the phytochemical constituents in Bergenia purpurascens in photodynamic wound healing healing.
- Funding Agency
- Research Ireland
- Date From
- 01-03-2026
- Date To
- 28-02-2030
Recognition
Representations
Ireland representative on Committee 13b of the European Pharmacopoeia, Strasbourg.
Awards and Honours
Henkel Award (Organic Chemistry)
Deans Award for Innovation in Teaching
Commendation for being shortlisted for a Provost's Teaching Award
Memberships
The Society for Medicinal Plant Research
Phytochemical Society of Europe
European Histamine Research Society