Models of Disease
Researchers in TCIN have developed a range of models offering the ability to study the following diseases:
Alzheimer’s disease and cognitive impairment |
Stroke, Ischemia and Cell Stress |
- Transgenic models of Alzheimer’s disease
- Aβ infusion models
- Aged model
- Basal forebrain cholinergic lesion model
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- Middle Cerebral Artery Occlusion (MCAO) model
- Traumatic brain injury
- Oxygen-glucose deprivation
- Hypoxia/re-oxygenation
- Excitotoxicity (glutamate, NMDA, kainate)
- Oxidative stress
- Inflammatory stress
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Depression |
Other disease models: |
- Interferon-α-induced depression
- Olfactory bulbectomy
- Chronic mild stress
- Restraint stress
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- Prion disease: ME7 mouse model
- Motor neurone disease
- Macular degeneration and retinitis pigmentosa
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Multiple Sclerosis |
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| EAE (including relapsing/remitting); mice and rats |
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Therapeutic Interventions
Researchers in TCIN use both pharmacological and non-pharmacological interventions to ameliorate pathology in a variety of disease models.
Methodologies for CNS delivery of therapeutics |
Non-pharmacological interventions |
- Intrahippocampal and other deep sites
- Intracerebroventricular
- Osmotic minipump chronic infusion
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- Electroconvulsive stimulation
- Deep brain stimulation
- Exercise protocols
- Dietary manipulation
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