Assoc. Prof. Stephen G. Maher
Associate Professor in Translational Oncology
- Research Institute:
Cancer Chemoradiation Research Group, Trinity Translational Medicine Institute (TTMI)
- Contact e-mail:
- Research Area(s):
Pancreatic cancer, Oesophageal cancer, radiotherapy, radiobiology, chemotherapy, microRNAs, drug trafficking/flux, multi-omics, pancreatic cystic lesions, biobank.
Research Description:
The focus of my research group lies in gastrointestinal malignancies, particularly pancreatic and oesophageal cancer. Here, my research aims to understand the cellular and molecular mechanisms underpinning responses and resistance to anti-cancer therapeutics, particular radiotherapy and chemotherapy. Consequently, we have identified several promising new drug target candidates for radio- and chemo-sensitisation. I am also interested in transcriptomic and proteomic signatures that are predictive of patient response to therapy. More recently I have significant interest in pre-malignant pancreatic cystic lesions and cancer risk stratification. We are working towards the establishment of a new multi-omic risk stratification algorithm for patients with pancreatic cystic lesions. Furthermore, I have significant interest in the molecular and cellular biology, including immunology, behind malignant progression during the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Our cancer research is of a highly translational nature and involves close collaboration with scientist and clinician colleagues at Trinity College Dublin, St. James's Hospital, Tallaght University Hospital, and abroad.
