Professor Laure Marignol
Professor In Radiation Biology, Radiation Therapy
Biography
Professor Laure Marignol is Professor in Radiation Biology and Head of the Discipline of Radiation Therapy in the School of Medicine at Trinity College Dublin. She is an Elected Fellow of the University and founder of Applied Radiation Therapy Trinity (ARTT), one of Ireland's leading multidisciplinary radiation biology research programmes. Her research seeks to understand why biologically similar tumours respond differently to radiotherapy and how biological discovery can improve cancer care. Over the past two decades, her work has advanced understanding of tumour hypoxia, radioresistance, molecular biomarkers and tumour response modelling. More recently, her research has focused on tumour sex chromosome biology, leading to the development of OSIRIS, a research programme investigating tumour sex chromosome state as a novel determinant of tumour behaviour and radiation response. Professor Marignol's research integrates laboratory biology, computational approaches and clinical datasets to identify previously overlooked biological determinants of treatment response. While grounded in radiation biology, her work increasingly spans multidisciplinary collaborations with clinicians, physicists, computer scientists and researchers across emerging fields to accelerate the translation of biological discoveries into precision oncology. Alongside her research, Professor Marignol has played a leading role in advancing radiation biology through education, mentorship and international scientific leadership. She has established research capacity within radiation therapy through ARTT, supervised doctoral researchers, developed innovative research education programmes adopted across Trinity College Dublin, and contributed extensively to international education through the European Society for Radiotherapy and Oncology (ESTRO). She serves as Associate Editor for leading international oncology journals and contributes to research funding, professional societies and clinical guideline development across Europe. Professor Marignol believes that the greatest advances in cancer research arise from combining scientific curiosity with multidisciplinary collaboration. Her vision is to expand the contribution of radiation biology beyond its traditional boundaries, ensuring that biological discovery informs research, clinical practice and ultimately improves outcomes for people living with cancer.
Publications and Further Research Outputs
Peer-Reviewed Publications
Sarah Barrett , Mohammad Zahid , Conor K McGarry , Heiko Enderling , Gerard M Walls , Laure Marignol, External Validation of The Proliferation Saturation Index Model in Predicting Tumour Volume Regression in Patients with Non-Small Cell Lung Cancer Undergoing Radiation Therapy, International Journal of Radiation Oncology, Biology, Physics, 2026
Sarah Barrett, Laure Marignol, Gerard G Hanna, Conor K McGarry , Gerard M Walls, Monitoring lung tumour volume on daily cone beam CT; is it achievable in a real-world setting?, Technical Innovations & Patient Support in Radiation Oncology, 2025
Townsend, L. and Dunne, J. and Sui, J. and Sanchez Perez, C. and McElheron, M. and Reid, C. and McCormack, W. and Bergin, C. and Fleming, C. and O'Farrelly, C. and Brady, G. and Conlon, N., Immune response in vaccinated healthcare workers with frequent COVID-19 infections is characterised by blunted IFNγ and IL-2 responses to SARS-CoV-2 variants, Clinical Immunology, (110371), 2024
Ward M.E., Geary U., Brennan R., Vining R., McKenna L., O'Connell B., Bergin C., Byrne D., Creagh D., Fogarty M., Healy U., McDonald G., Ebiele M., Crane M., Pham M.-K., Bendechache M., Bezbradica M., Liang J., Doyle B., Guilfoyle J., Shuhaiber A., McDonald N., A systems approach to managing the risk of healthcare acquired infection in an acute hospital setting supported by human factors ergonomics, data science, data governance and AI, Ergonomics, 2024
McDermott A., Murphy N., Reddin C., Bergin C., The experiences of individuals living with HIV in Ireland attending out-patient physiotherapy, AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 36, (3), 2024, p368 - 373, p368-373
Collier, R. and Leech, M. and Marignol, L. and Gaffney, J. and Leijenaar, R. and Malone, C., Creating a 3D-printed pelvic phantom to explore the impact of Magnetic Resonance (MR) scanner noise in radiomics analysis, a technical note., Annals of 3D Printed Medicine, 13, (100143), 2024
Ripoll-Viladomiu, I. and Prina-Mello, A. and Movia, D. and Marignol, L., Extracellular vesicles and the â six Rsâ in radiotherapy, Cancer Treatment Reviews, 129, (102799), 2024
SK Zazzera , C Poole & L Marignol, Investigating the Needs and Concerns of Lesbian, Gay, Bisexual, Transgender, Queer, or Questioning Cancer Patients, Journal of Homosexuality, 2024
Marignol, L. and McMahon, S.J., Research Trends in the Study of the Relative Biological Effectiveness: A Bibliometric Study, Radiation Research, 202, (2), 2024, p177-184
Marignol, L. and Pugh, C.W., Time, location and function of hypoxia-inducible factors are critical to therapeutic tumour response, BMJ Oncology, 3, (1), 2024
Sarah Barrett, Mohammad U. Zahid, Heiko Enderling, Laure Marignol., Predicting Individual Tumor Response Dynamics in Locally Advanced Non-Small Cell Lung Cancer Radiation Therapy: A Mathematical Modelling Study, International Journal of Radiation Oncology Biology and Physics, 121, (4), 2024, p1077 - 1087
Grimes, D.R. and Rassamegevanon, T. and Marignol, L., In silico analysis of overall survival with YBX1 in male and female solid tumours, Scientific Reports, 14, (1), 2024
Hughes G., Cunney R., Mockler D., Talento A.F., Leary A.O., Bergin C., Use of complexity theory to inform antimicrobial stewardship: a scoping review, Journal of Hospital Infection, 2024
O'Brien K.K., Erlandson K.M., Brown D.A., Carusone S.C., Vera J.H., Bergin C., Avery L., Bayoumi A.M., Hanna S.E., Harding R., Solomon P., Clair-Sullivan N.S., O'Shea N., Murray C., Boffito M., Da Silva G., Torres B., McDuff K., Davis A.M., Episodic disability questionnaire (EDQ) measurement properties among adults living with HIV in Canada, Ireland, United Kingdom, and United States, BMC Infectious Diseases, 24, (1), 2024
Harris E, Marignol L., Prehabilitation for Patients with Cancer Undergoing Radiation Therapy: a Scoping Review., Clinical oncology (Royal College of Radiologists (Great Britain)), 36, (4), 2024, p254-264
Vens, C. and van Luijk, P. and Vogelius, R.I. and El Naqa, I. and Humbert-Vidan, L. and von Neubeck, C. and Gomez-Roman, N. and Bahn, E. and Brualla, L. and Böhlen, T.T. and Ecker, S. and Koch, R. and Handeland, A. and Pereira, S. and Possenti, L. and Rancati, T. and Todor, D. and Vanderstraeten, B. and Van Heerden, M. and Ullrich, W. and Jackson, M. and Alber, M. and Marignol, L., A joint physics and radiobiology DREAM team vision â" Towards better response prediction models to advance radiotherapy, Radiotherapy and Oncology, 196, (110277), 2024
Quigley C., Stephenson K.A.J., Kenna P.F., Cassidy L., Peripapillary retinal nerve fibre layer thinning, perfusion changes and optic neuropathy in carriers of Leber hereditary optic neuropathy-associated mitochondrial variants, BMJ Open Ophthalmology, 9, (1), 2024
Temperley H.C., Mac Curtain B.M., O'Sullivan N.J., Mulhall C., Temperley T.S., Mehigan B.J., Larkin J.O., McCormick P.H., Kerr C., Gallagher D., Bergin C., Gillham C., Kelly M.E., Factors Influencing Outcomes and Survival in Anal Cancer, Current Oncology, 31, (9), 2024, p5151 - 5163, p5151-5163
Leech, M. and Leijenaar, R.T.H. and Hompland, T. and Gaffney, J. and Lyng, H. and Marignol, L., Exploring Hypoxia in Prostate Cancer With T2-weighted Magnetic Resonance Imaging Radiomics and Pimonidazole Scoring, Anticancer Research, 43, (1), 2023, p351-357
Marignol L., Generation of Radioresistant Prostate Cancer Cells., Methods in molecular biology (Clifton, N.J.), 2645, 2023, p129-138
Liu T, Dahle MA, Lystad MH, Marignol L, Karlsen M, Redalen KR., In vitro and in vivo characterization of [64Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors., European journal of nuclear medicine and molecular imaging, 50, (12), 2023, p3576-3588
Forde E, Robert C, Leech M, Marignol L., Spatial Resampling Combined with Intensity Discretization Improves Reproducibility of Radiomic Features of the Parotid Gland. (e-poster #604, European Congress of Medical Physics, Dublin, Ireland, August 2022, 2022
Radio-resistant in vitro models for cancer research in, editor(s)Adriele Prina-Mello Dania Movia , Methods in Cancer Cell Culture, Springer Nature, 2022, [Laure Marignol]
Forde E, Leech M, Robert C, Heron E, Marignol L, Influence of Inter-Observer Delineation Variability on Radiomic Features of the Parotid Gland, Physica Medica, (82), 2021, p240 - 248
Leech M, Leijenaar R, Hompland T, Gaffney J, Lyng H, Marignol L, Exploring hypoxia in prostate cancer with T2-weighted MRI radiomics and pimonidazole scoring, Radiotherapy and Oncology, ESTRO 2021, Madrid, Spain, 161, Elsevier, 2021, ppS1526 - S1527
Adrian Fuentes-Bonachera, Darragh Waters, A. Meunier, Rustom P. Manecksha, Laure Marignol, Thomas H. Lynch, Sex in Bladder cancer research: an overview, SN Comprehensive Clinical Medicine, 2021
Armelle Meunier, Laure Marignol, The radiotherapy cancer patient: female inclusive, but male dominated, International Journal of Radiation Biology, 2020, p1--21
Michelle Leech, Sarah Osman, Suneil Jain, Laure Marignol, Mini review: Personalization of the radiation therapy management of prostate cancer using MRI-based radiomics, Cancer Letters, 2020
Bates, Mark, Boland, Anna, McDermott, Niamh, Marignol, Laure, YB-1: The key to personalised prostate cancer management?, Cancer Letters, 2020
Sarah Barrett, Michelle Leech, Dr Laure Marignol, Time trend analysis of target volume auto-contouring in locally advanced NSCLC over the course of RT, ESTRO 2020, Vienna, Austria, 2020
Darragh Waters , Adrian Fuentes-Bonachera , Armelle Meunier , Rustom P. Manecksha, Laure Marignol and Thomas H. Lynch, Kidney Cancer Research: Sex-Inclusive but Sex-Unspecific, Clinical Oncology and Research, 2020
Clerkin, James and Connor, Kate and Sweeney, Kieron and White, Kieron and Shiels, Liam and Maher, Stephen and Marignol, Laure and Prehn, Jochen H. M. and O'Brien, David and Byrne, Annette, ESTABLISHING A CLINICALLY RELEVANT MODEL OF MESENCHYMAL GLIOBLASTOMA (GBM) TO STUDY RESPONSE TO STANDARD OF CARE TREATMENT AND IMMUNE CHECKPOINT INHIBITION (ICI)., 25th Virtual Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), ELECTR NETWORK, NOV 19-21, 2020, 22, (2), 2020, pp230
James Clerkin, Kate Connor, Kieron Sweeney, Kieron White, Stephen G. Maher, Laure Marignol, Jochen Prehn , David O'Brien, Annette T. Byrne, Establishing a clinically relevant model of Glioblastoma in young and aged mice, encompassing standard of care treatment and immune checkpoint inhibition (ICI, Irish Association for Cancer Research , Galway, February 2020, 2020
Barrett S , Simpkin AJ , Walls G , Leech M , Marigno Ll , Geometric and dosimetric evaluation of a commercially available auto-segmentation tool for gross tumour volume delineation in locally advanced Non-Small Cell Lung Cancer: a feasibility study, Journal of Clinical Oncology, 2020
Wei Ang, Laure Marignol, Pro-con of proton: dosimetric advantages of intensity-modulation over passive scatter for thoracic malignancies , Technical Innovations & Patient Support in Radiation Oncology, 2020
Elizabeth Forde, Michelle Leech, Charlotte Robert, Elizabeth Heron, Laure Marignol, Influence of Inter-Observer Delineation Variability on Radiomic Features of the Parotid Gland, Radiotherapy and Oncology, ESTRO2020, Online, August 2020, 2020
Laure Marignol, Radiobiology of particles therapy: principles and latest advances, ESTRO meets Asia , Singapore, 2019, European Society for Radiotherapy and Oncology
S Inder, M Bates, N Ni Labhrai, N McDermott, J Schneider, G Erdmann, T Jamerson, AN Flores, A Prina-Mello, P Thirion, PR Manecksha, D Cormican, S Finn, T Lynch, L Marignol, Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance, Scientific Reports, 9, 2019, p1 - 12
Laure Marignol, Molecular radiation response of breast cancer: advances and clinical potential, ESTRO meets Asia , Singapore, 6-8th December, 2019, European Society for Radiotherapy and Oncology
Barrett S, Thirion P, Harper D, Simpkin A, Leech M, Hickey K, Ryan L, Marignol L, Dosimetric impact of uncorrected systematic yaw rotation in VMAT for peripheral lung SABR, . Reports of Practical Oncology & Radiotherapy, 24, (6), 2019, p520 - 527
Marignol L., Predicting Treatment Outcomes: The Case for Hypoxia Gene Signatures., EBioMedicine, 2018
Griffin F., Marignol L., Therapeutic potential of melatonin for breast cancer radiation therapy patients, International Journal of Radiation Biology, 94, (5), 2018, p472 - 477
Wall V, Marignol L, ElBeltagi N., Image-Guided Radiotherapy in Paediatrics: A Survey of International Patterns of Practice., Journal of medical imaging and radiation sciences, 49, (3), 2018, p265-269
Elbeltagi M.N., Wall V., Marignol L., Planning target volume (PTV) margin practice patterns in adults and paediatrics among the Paediatric Radiation Oncology Society (PROS) members: An international survey, Journal of Radiotherapy in Practice, 17, (4), 2018, p373 - 376
Sarah Barrett, Gerard G. Hanna, Laure Marignol, An overview on personalisation of radiotherapy prescriptions in locally advanced non-small cell lung cancer: Are we there yet?, Radiotherapy and Oncology, 128, (3), 2018, p520 - 533
Glynn A, Marignol L, Forde E, Focal therapy: A treatment option for localized prostate cancer? , Advances in Modern Oncology Research, 2018
Mascan, B. and Marignol, L., Aspirin in the management of patients with prostate cancer undergoing radiotherapy: Friend or Foe?, Anticancer Research, 38, (4), 2018, p1897-1902
Mascan, B., Marignol, L., Aspirin in the management of patients with prostate cancer undergoing radiotherapy: Friend or Foe?, Anticancer Research, 38, (4), 2018, p1897-1902
Elbeltagi, M.N., Wall, V., Marignol, L., Planning target volume (PTV) margin practice patterns in adults and paediatrics among the Paediatric Radiation Oncology Society (PROS) members: An international survey, Journal of Radiotherapy in Practice, 17, (4), 2018, p373-376
Inder, S, Bates, M, McDermott, N, Saluzzo, J, Ni Labhrai, N , Schneider, J, Erdmann, G, Lynch, , Marignol, L, Lessons from isogenic models of radioresistant prostate cancer cells, 37th Meeting of the European-Society-for-Radiotherapy-and-Oncology (ESTRO), Barcelona, SPAIN, 2018
Fiona Griffin, Laure Marignol, Therapeutic potential of melatonin for breast cancer radiation therapy patients, International Journal of Radiation Biology, 2018, p1--6
Wall, V., Marignol, L., ElBeltagi, N., Image-Guided Radiotherapy in Paediatrics: A Survey of International Patterns of Practice, Journal of Medical Imaging and Radiation Sciences, 49, (3), 2018, p265-269
Sarah Caufield, Laure Marignol, Gerard Menezes, Claire Poole, Nomograms are key decision making tools in prostate cancer radiation therapy, Urologic Oncology: Seminars and Original Investigations, 36, (6), 2018, p283 - 292
McDermott N, Inder S, Schneider J, Erdmann G,Meunier A., Lynch T, Marignol L, Radioresistance profiling identifies Notch-3 signalling as a molecular switch to molecular radiation response of prostate cancer cells , 15th International Wolfsberg Meeting, Switzerland, 2017
Inder, S., O'Rourke, S., McDermott, N., (...), Lynch, T., Marignol, L. , The Notch-3 receptor: A molecular switch to tumorigenesis?, Cancer treatment reviews, 60, 2017, p69-76
Fitzpatrick C, Lynch O, Marignol L., 68Ga-PSMA-PET/CT Has a Role in Detecting Prostate Cancer Lesions in Patients with Recurrent Disease., Anticancer research, 37, (6), 2017, p2753-2760
McDermott, N. and Meunier, A. and Jameson, T. and Mansour, A. and Haynes, C. and Flores, A. and O'Callaghan, A. and Marignol, L., Novel molecular radiobiology for personalised prostate cancer radiotherapy, RADIOTHERAPY AND ONCOLOGY, 123, (1), 2017, pS200
Haruna, F., Lipsett, A., Marignol, L. , Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis., Anticancer research, 37, (10), 2017, p5343-5353
McDermott, N., Meunier, A., Wong, S., Buchete, V., Marignol, L., Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs, Clinical and Translational Radiation Oncology, 2, 2017, p63-68
McDermott N,Inder S, Schneider J, Erdmann G, Meunier A., Lynch T, Marignol L, Identifying a novel molecular switch of the radiation response of prostate cancer cells, Radiation Research Society Annual Meeting, Cancun, Mexico, October 15-18, 2017
Inder, S. and Bates, M. and McDermott, N. and Domad, J. and Schneider, J. and Erdmann, G. and Finn, S. and Manecksha, R. P. and Lynch, T. H. and Marignol, L., Profiling of radioresistant prostate cancer cells identifies deregulation of key protein, BJU INTERNATIONAL, 120, (2, SI), 2017, p24
Fitzpatrick, C., Lynch, O., Marignol, L., 68Ga-PSMA-PET/CT has a role in detecting prostate cancer lesions in patients with recurrent disease, Anticancer Research, 37, (6), 2017, p2753-2760
Hutchinson, J., Marignol, L. , Clinical Potential of Statins in Prostate Cancer Radiation Therapy., Anticancer research, 37, (10), 2017, p5363-5372
Laure Marignol, Gene editing: How this technique can be used to study radiation responses?, 2017, S1 - S1pp
O'Brien, R. and Marignol, L., The Notch-1 receptor in prostate tumorigenesis, Cancer Treatment Reviews, 56, 2017, p36-46
Marignol, L., Notch signalling: The true driver of small cell lung cancer?, Translational Cancer Research, 6, 2017, pS1191-S1196
McDermott N., Meunier A., Wong S., Buchete V., Marignol L., Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs, Clinical and Translational Radiation Oncology, 2, 2017, p63 - 68
Samsuri, N.A.B. and Leech, M. and Marignol, L., Metformin and improved treatment outcomes in radiation therapy â" A review, Cancer Treatment Reviews, 55, 2017, p150-162
Inder, S. and Bates, M. and McDermott, N. and Domad, J. and Schneider, J. and Erdmann, G. and Finn, S. and Manecksha, R. P. and Lynch, T. H. and Marignol, L., Identification of a protein signature of radioresistance in a prostate cancer model, The British Association for Urological Surgeons, 120, 2017, pp24-24
Devine, A. and Marignol, L., Meta-analysis: can amifostine reduce chemoradiotherapy and radiotherapy toxicity in advanced NSCLC?, RADIOTHERAPY AND ONCOLOGY, 119, (1), 2016, pS964
McDermott, N.; Meunier, A.; Haynes, C.; Flores, A.; O'Callaghan, A.; Marignol, L., Therapeutic potential of the YB-1/Notch-3 interaction in prostate cancer, 35th Scientific Meeting of the European Society for Radiotherapy and Oncology (ESTRO), Turin, Italy, 2016
Michelle Leech, John Gaffney, Laure Marignol, Improving non-invasive detection of prostate cancer using diffusion-weighted MRI, Advances in Modern Oncology Research , 2, (6), 2016
Meunier A., Flores A., McDermott N., Rivera-Figueroa K., Perry A., Lynch T., Redalen K., Marignol L., Hypoxia regulates Notch-3 mRNA and receptor activation in prostate cancer cells, Heliyon, 2, (5), 2016
Wall, V. and Marignol, L. and Elbeltagi, M. N., Radiotherapy in Paediatrics: A Survey of International Patterns of Practice of Image Guided Radiation Therapy and Planning Target Volume, 63, 2016, ppS64-S64
Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397
Devine A, Marignol L, Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis., Anticancer research, 36, (1), 2016, p5-12
McDermott N., Meunier A., Mooney B., Nortey G., Hernandez C., Hurley S., Hurley S., Lynam-Lennon N., Barsoom S., Bowman K., Marples B., Jones G., Marignol L., Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells, Scientific Reports, 6, 2016
Lawlor H, Meunier A, McDermott N, Lynch TH, Marignol L, Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells., Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36, (8), 2015, p6019-28
Dullea A, Marignol L, MGMT testing allows for personalised therapy in the temozolomide era., Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015
Moran DC, Marignol L, Fagan AJ, Dunne R, Perry AS, O'Driscoll D, Gaffney E, Lynch TH, Meaney JFM, Hollywood DH, Threshold-based parametric analysis of diffusion-weighted magnetic resonance imaging at 3.0 Tesla to identify men with prostate cancer, Adv Mod Oncol Res , 1, (2), 2015, p141 - 150
McDermott, N. and Meunier, A. and Hernandez, C. and Bowman, K. J. and Jones, G. D. and Marignol, L., Identification of a miRNAs signature of radioresistance in a prostate cancer model, 75, 2015
Lim D, Quah DS, Leech M, Marignol L, Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer., Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015
McDermott, N. and Meunier, A. and Hernandez, C. and Bowman, K. J. and Jones, G. D. and Marignol, L., Identification of MiRNAs associated with radioresistance in a prostate cancer model, RADIOTHERAPY AND ONCOLOGY, 115, (1), 2015, pS670
, A novel Interactive Health Communication Application (IHCA) for parents of children with long-term conditions: development, implementation and feasibility assessment, Inform Health Soc Care, 2015
Floyd, R. and McDermott, N. and Meunier, A. and Marignol, L., Radiosensitisation properties of PI3K/AKT inhibitor GDC-0941 in prostate cancer cells, RADIOTHERAPY AND ONCOLOGY, 115, (1), 2015, pS572
McLaughlin, J., Marignol, L., Radiotherapy scheduling using prime numbers, Journal of Radiotherapy in Practice , 13, (3), 2014, p317-321
Marignol, L., Targeting notch in prostate cancer - Combination is the key, 11, (7), 2014
Kelada O, Marignol L, Erythropoietin-stimulating agents and clinical outcomes in metastatic breast cancer patients with chemotherapy-induced anemia: a closed debate?, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35, (6), 2014, p5095-100
Martin, L.M., Marples, B., Lynch, T.H., Hollywood, D., Marignol, L., Erratum to Exposure to low dose ionizing radiation: Molecular and clinical consequences [Cancer Lett. 338 (2) (2013) 209-218], 349, (1), 2014
Flores AN, McDermott N, Meunier A, Marignol L, NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer., Nature reviews. Urology, 11, (9), 2014, p499-507
Scientific Report, Nature, [eds.], 2014
Azmi A, Dillon RA, Borghesi S, Dunne M, Power RE, Marignol L, O'Neill BD, Active surveillance for low-risk prostate cancer: diversity of practice across Europe., Irish journal of medical science, 2014
Martin LM, Marples B, Davies AM, Atzberger A, Edwards C, Lynch TH, Hollywood D, Marignol L, DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells., Cancer letters, 2013
Vajda A, Marignol L, Barrett C, Madden SF, Lynch T, Hollywood D, Perry AS, Gene expression in prostate cancer: the importance of the endogenous control. , The Prostate, 2013
McDermott N, Meunier A, Lynch T, Hollywood D, Marignol L, Isogenic radiation resistant cell lines: Development and Validation strategies., International journal of radiation biology, 2013
Perry, A.S. and O'Hurley, G. and Raheem, O.A. and Brennan, K. and Wong, S. and O'Grady, A. and Kennedy, A.M. and Marignol, L. and Murphy, T.M. and Sullivan, L. and Barrett, C. and Loftus, B. and Thornhill, J. and Hewitt, S.M. and Lawler, M. and Kay, E. and Lynch, T. and Hollywood, D., Erratum: Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer (International Journal of Cancer (2013) 132:8 (1771-80) DOI: 10.1002/ijc.27798)), International Journal of Cancer, 132, (11), 2013
Bolton, E. M. and Moran, D. and Meunier, A. and Vajda, A. and O'Kelly, F. and Thurman, J. and O'Connor, R. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A. S., Epigenetic profiling in urine for the detection of aggressive prostate cancer, 100, 2013, pp63-63
Martin LM, Marples B, Lynch TH, Hollywood D, Marignol L, Exposure to Low Dose Ionizing Radiation: Molecular and Clinical Consequences., Cancer letters, 2013
Davies, A.M., Vajda, A., Ryan, S.L., Marignol, L., New approaches to cell based assays for high content screening and analysis, 18, (3), 2013, p23-28
Marignol L, Rivera-Figueroa K, Lynch T, Hollywood D, Hypoxia, notch signalling, and prostate cancer., Nature reviews. Urology, 10, (7), 2013, p405-13
Bolton, E. M. and Moran, D. C. and Meunier, A. and O'Kelly, F. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A. S., Real time expression analysis of a microRNA signature of prostate cancer in prostate cell lines and tissue specimens, 100, 2013, pp63-63
Schoenherr D, Krueger SA, Martin L, Marignol L, Wilson GD, Marples B, Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: A cell line study in four glioblastoma multiforme (GBM) cell lines., International journal of radiation biology, 2013
Mongan, A. M. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J. N. and Reynolds, J. V., Obesity and radiosensitivity status influence genomic instability events: Anaphase bridge formation and spindle assembly checkpoint gene expression in oesophageal cancer, 100, 2013, pp48-48
Røe K, Bratland A, Vlatkovic L, Ragnum HB, Saelen MG, Olsen DR, Marignol L, Ree AH, Hypoxic Tumor Kinase Signaling Mediated by STAT5A in Development of Castration-Resistant Prostate Cancer., PloS one, 8, (5), 2013, pe63723
Mongan, A. M. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and O'Farrell, N. J. and Pidgeon, G. and O'Sullivan, J. and Reynolds, J. V., Obesity fuels genomic instability and radioresistance in oesophageal cancer, 182, 2013, ppS38-S38
Mongan, A. M. and Reynolds, J. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J., Obesity Status Influence Nuclear Instability Events: Anaphase Bridge Formation and Spindle Assembly Checkpoint Gene Expression in Oesophageal Cancer, 181, 2012, ppS152-S153
James C. Forde, Laure Marignol, Ophelia Blake, Ted McDermott, Ronald Grainger, Vivien E. Crowley, Thomas H. Lynch, Standardization of assay methods reduces variability of total PSA measurements: an Irish study, 2012
Azmi, Aini and Dillon, Ruth and Marignol, Laure and Borghesi, Simona and Dunne, Mary and Power, Richard and O'Neill, Brian, Active surveillance for low-risk prostate cancer: Practice across Europe, Journal of Clinical Oncology, 30, (5), 2012
O'Kelly F, Marignol L, Meunier A, Lynch TH, Perry AS, Hollywood D, MicroRNAs as putative mediators of treatment response in prostate cancer., Nature reviews. Urology, 2012
Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, Barrett C, Loftus B, Thornhill J, Hewitt SM, Lawler M, Kay E, Lynch T, Hollywood D, Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer., International journal of cancer. Journal international du cancer, 2012
Roe, K. and Mikalsen, L. T. G. and van der Kogel, A. J. and Bussink, J. and Lyng, H. and Ree, A. H. and Marignol, L. and Olsen, D. R., DCEMRI IN ASSESSMENT OF TUMOR NEOVASCULARIZATION AFTER ANDROGEN-DEPRIVATION IN EXPERIMENTAL PROSTATE CANCER: CORRELATION TO QUANTITATIVE IMMUNOHISTOCHEMISTRY, RADIOTHERAPY AND ONCOLOGY, 102, (1), 2012, pS68
O'Kelly, F. and Perry, A. S. and Meunier, A. and Wong, S. and Hollywood, D. and Marignol, L. and Lynch, T. H., Over-expression of a novel microRNA, miR-24, affects prostate cancer cell growth and proliferation, and contributes to radio-senstivity of prostate cancer cells in vitro, 11, (1), 2012, ppE849-U790
Røe K, Mikalsen LT, van der Kogel AJ, Bussink J, Lyng H, Ree AH, Marignol L, Olsen DR, Vascular responses to radiotherapy and androgendeprivation therapy in experimental prostate cancer., Radiation oncology (London, England), 7, (1), 2012, p75
Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012
Bolton, E. and Moran, D. and Meunieur, A. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A., Real Time Expression Analysis of a Microrna Signature of Prostate Cancer in Prostate Cell Lines and Tissue Specimens, 181, 2012, ppS169-S170
Lynam-Lennon, Niamh and Reynolds, John V. and Marignol, Laure and Sheils, Orla M. and Pidgeon, Graham P. and Maher, Stephen G., miR-31 modulates tumor sensitivity to radiation in esophageal cancer by regulation of DNA repair genes, CANCER RESEARCH, 71, (8), 2011
Hennessey, D. and Coffey, M. and Lynch, T. and Lawler, M. and Hollywood, D. and Marignol, L., Adaptation to low oxygenation levels modify the radioresponse of prostate cancer cells in vitro, 98, (6), 2011, ppE8-E8
Forde JC, Maginn EN, McNamara G, Martin LM, Campiani G, Williams DC, Zisterer D, McElligott AM, Lawler M, Lynch TH, Hollywood D, Marignol L, Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro., Cancer biology & therapy, 11, (4), 2011, p421-8
Forde, J. C. and Perry, A. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L., Downregulation of HIF-1 A and lowered TUBB3 expression levels leads to preferential sensitivity of hypoxic prostate cancer cells tol docetaxel, 98, (6), 2011, ppE8-E8
Hennessey D, Martin LM, Atzberger A, Lynch TH, Hollywood D, Marignol L, Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells., Urologic oncology, 1, 2011
Moran, D. and Marignol, L. and Fagan, A. and Hollywood, D. and Meaney, J. and Lynch, T., Functional endorectal MRI at 3 Tesla for the detection and staging of prostate cancer: Correlation with prostatectomy specimens, 180, 2011, ppS269-S270
Foley R, Marignol L, Keane JP, Lynch TH, Hollywood D., Androgen hypersensitivity in prostate cancer: molecular perspectives on androgen deprivation therapy strategies, Prostate, 71, (5), 2011
Forde, James and Blake, Ophelia and Marignol, Laure and McDermott, T. E. D. and Grainger, Ronald and Crowley, Vivion and Lynch, Thomas, DEMONSTRATION OF THE VARIABILITY OF THE DIFFERENT TOTAL PSA ASSAYS CURRENTLY IN USE THROUGHOUT IRISH HOSPITALS, JOURNAL OF UROLOGY, 185, (4, S), 2011, pE817
Forde, J. C. and Maginn, E. and McElligott, A. M. and Martin, L. M. and Williams, D. C. and Zisterer, D. and Lawler, M. and Hollywood, D. and Lynch, T. H. and Marignol, L., AN IN VITRO INVESTIGATION OF THE CYTOTOXIC AND RADIO-SENSITISING PROPERTIES OF A NOVEL MICROTUBULE TARGETING AGENT, PBOX-15, IN HYPOXIC PROSTATE CANCER CELL LINES, European Urology Supplements, EAU, 10, (2), 2011, pp292-292
Lennon, N. Lynam and Reynolds, J. V. and Marignol, Laura and Sheils, O. M. and Pidgeon, G. P. and Maher, S. G., MiR-31 modulates tumour sensitivity to radiation in oesophageal cancer, 180, 2011, ppS276-S276
Mongan, A. M. and Reynolds, J. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J., Levels of obesity influences a nuclear instability event: Anaphase bridge formation in oesophageal cancer, 180, 2011, ppS262-S262
Vajda A, Marignol L, Foley R, Lynch TH, Lawler M, Hollywood D, Clinical potential of gene-directed enzyme prodrug therapy to improve radiation therapy in prostate cancer patients., Cancer treatment reviews, 37, (8), 2011, p643-54
Forde, J. C. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L. and Marignol, L., Investigation of the cytotoxic properties of a novel microtubule-targeting compound, PBOX-15, in hypoxic prostate cancer cell lines, Bju International, 106, (1), 2010, pp52-53
Foley R, Marignol L, Keane JP, Lynch TH, Hollywood D, Comment on "Androgen-hypersensitive preclinical model of prostate cancer" by Kawata et al., The Prostate, 71, (6), 2010, p559 - 560
Forde, J. C. and Maginn, E. and McElligott, A. M. and Martin, L. M. and Williams, D. C. W. and Zisterer, D. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L., RADIOSENSITIZATION OF HYPOXIC PROSTATE CANCER CELL LINES USING A NOVEL MICROTUBULE TARGETING AGENT: PBOX-15, Irish Journal of Medical Science, IACR, 179, 2010, ppS372-S372
Hennessey, D. and Martin, L. and Hollywood, D. and Lynch, T. H. and Marignol, L., EXPOSURE TO REDUCED OXYGENATION FOLLOWING RADIATION EXPOSURE ENHANCES THE SURVIVAL OF PROSTATE CANCER CELLS IN VITRO: IMPLICATIONS FOR RADIATION THERAPY DELIVERY, Irish Medical Science Journal , IACR, 179, 2010, ppS351-S351
Marignol, L., 5-STEP GUIDE TO THE MANAGEMENT OF A RESEARCH PROJECT, RADIOTHERAPY AND ONCOLOGY, 96, (1), 2010, pS164
Martin L, Coffey M, Lawler M, Hollywood D, Marignol L, DNA mismatch repair and the transition to hormone independence in breast and prostate cancer., Cancer letters, 291, (2), 2010, p142-9
Martin LM, Marples B, Coffey M, Lawler M, Lynch TH, Hollywood D, Marignol L, DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data., Cancer treatment reviews, 36, (7), 2010, p518-27
Keane, J. P. and Foley, R. and Marignol, L. and Hollywood, D. and Lynch, T. H., THE EFFECT OF CALPAIN ACTIVATION IN THE 22Rv1 PROSTATE CANCER CELL LINE, 179, 2010, ppS350-S350
Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG, Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma., Radiation research, 174, (6), 2010, p703 - 711
Kelada, O. J. and Marignol, L., DOES THE USE OF ERYTHROPOIETIN-STIMULATING AGENTS IN BREAST CANCER PATIENTS WITH CHEMOTHERAPY-INDUCED ANAEMIA IMPACT ON CLINICAL OUTCOMES ? A CRITICAL REVIEW OF THE LITERATURE, RADIOTHERAPY AND ONCOLOGY, 96, (1), 2010, pS578
Forde JC, Perry AS, Brennan K, Martin LM, Lawler MP, Lynch TH, Hollywood D, Marignol L, Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells., Urologic oncology, 1, 2010
Forde, J. C. and Blake, O. and Casey, R. G. and Marignol, L. and McDermott, T. E. and Grainger, R. and Crowley, V. E. and Lynch, T. H., THE INTER-HOSPITAL VARIABILITY OF 6 DIFFERENT PSA ASSAY KITS CURRENTLY IN USE THROUGHOUT IRELAND, Irish Journal of Medical Science, IACR, 179, 2010, ppS372-S372
Marignol, L. and Martin, L. and Coffey, M. and Lawler, M. and Lynch, T. and Hollywood, D., REDUCED OXYGENATION DOES NOT PROTECT ALL PRO STATE CANCER CELLS FROM RADIATION: A NEW ROLE FOR HYPOXIA IN RADIATION THERAPY?, RADIOTHERAPY AND ONCOLOGY, 96, (1), 2010, pS596
Perry, Antoinette S. and O'Hurley, Gillian and Raheem, Omer A. and O'Grady, Anthony and Kennedy, Anne -Marie and Barrett, Ciara and Marignol, Laure and Murphy, Therese M. and Sullivan, Linda and Loftus, Barbara and Hewitt, Stephen M. and Kay, Elaine and Lawler, Mark, Epigenetic discovery screen identifies SFRP2 as a novel biomarker of high grade prostate cancer, CANCER RESEARCH, 70, (8), 2010
Thomas, A. Z. and Foley, R. and Marignol, L. and Hollywood, D. and Lynch, T. and Lawlor, M., The effect of the HIF-1 alpha C1772T heterozygous genotype on prostate cancer risk and HIF-1 alpha expression in prostate tissue, 97, 2010, pp3-4
Raheem, O. A. and Perry, A. S. and Kennedy, A. M. and Murphy, T. M. and Foley, R. and Marignol, L. and Suillvan, L. and Loftus, B. and Lawler, M. and Lynch, T. H., INVESTIGATING PROMOTER METHYLATION OF WNT SIGNALLING ANTAGONISTS IN PROSTATE CANCER, EUROPEAN UROLOGY SUPPLEMENTS, 9, (2), 2010, p310
Marignol, L., Foley, R., Southgate, T.D., Coffey, M., Hollywood, D., Lawler, M., Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro., The Journal of Gene Medicine , 11, (2), 2009, p169-179
Raheem, O. A. and Powell, A. and Kennedy, A. M. and Murphy, T. and Foley, R. and Marignol, L., Investigation into methylation of the Secreted Frizzled Related Proteins (SFRP) family of Wnt antagonists in prostate cancer, 103, 2009, pp19-20
Lynn Martin, Brian Marples, Mary Coffey, Mark Lawler, Donal Hollywood, Laure Marignol, Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity., Radiation Research, 172, (4), 2009, p405 - 413
Foley R, Marignol L, Thomas AZ, Cullen IM, Perry AS, Tewari P, O'Grady A, Kay E, Dunne B, Loftus B, Watson WR, Fitzpatrick JM, Woodson K, Lehman T, Hollywood D, Lynch TH, Lawler M, The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers., Cancer biology & therapy, 8, (2), 2009, p118-24
Vajda, Alice and Marignol, Laure and Foley, Ruth and Hollywood, Donal and Lawler, Mark, Hypoxia, androgen and radiation-inducible suicide gene therapy for the treatment of prostate cancer, 20, (11), 2009, pp1519-1519
D'Arcy, F. and Foley, R. and Perry, A. and Marignol, L. and Lawler, M. and Gaffney, E. and Watson, R. G. W. and Fitzpatrick, J. M. and Lynch, T. H., No evidence of XMRV in irish prostate cancer patients with the R462q mutation, 7, (3), 2008, pp271-271
Marignol L, Coffey M, Lawler M, Hollywood D., Hypoxia in prostate cancer: a powerful shield against tumour destruction?, Cancer Treatment Reviews, 34, (4), 2008, p313-327
Marignol L, Robson T, McCarthy HO, Worthington J, Murray MM, Hollywood D, Lawler M, Hirst DG., The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?, Journal of Gene Medicine, 10, (9), 2008, p1032-1038
Marignol, L. and Foley, R. and Southgate, T. D. and Coffey, M. and Hollywood, D. and Lawler, M., Hypoxia-inducible suicide gene therapy approach radiosensitises prostate cancer cells, 100, 2007, pp32-32
Thomas, A. Z. and Marignol, L. and Foley, R. and Perry, A. and Tewari, P. and O'Grady, T. and Kay, E. and Dunne, B. and Loftus, B. and Hollywood, D. and Lynch, T. and Lawler, M., Enhanced expression of hypoxia markers in cell lines and in clinical specimens of malignant prostate tissue: A factor in disease progression?, 100, 2007, pp40-41
D'Arcy, F. and Foley, R. and Perry, A. and Marignol, L. and Gaffney, E. and Dunne, B. and Lawler, M. P. and Watson, R. W. G. and Fitzpatrick, J. M. and Lynch, T. H., RNASEL and its role in Irish prostate cancer patients, 100, 2007, pp12-13
Martin, L. and Marignol, L., Sequence effect on the survival of prostate cancer cells may potentiate daily radiation therapy delivery, 84, 2007, ppS281-S281
Foley, R. and Marignol, L. and Lawler, M., Prodrug activation therapy kills prostate cancer cells in a three-dimensional culture model, 100, 2007, pp24-24
Thomas, A. Z. and Marignol, L. and Foley, R. and Perry, A. and Tewari, P. and O'Grady, T. and Kay, E. and Dunne, B. and Loftus, B. and Hollywood, D. and Lynch, T. and Lawler, M., Enhanced expression of hypoxia markers in cell lines and in clinical specimens of malignant prostate tissue: A factor in disease progression?, 100, 2007, pp40-41
Marignol L, Coffey M, Hollywood D, Lawler M., Radiation to Control Transgene Expression in Tumors., Cancer Biological Therapy, 6, (7), 2007, p1005 - 1012
Traynor, S. and Gilham, C. and Foley, R. and Fairbairn, L. J. and Southgate, T. D. and Worthington, J. and Coffey, M. and Hollywood, D. and Lawler, M. and Marignol, L., Utilising a hypoxia-inducible suicide gene therapy strategy in combination with radiation to target prostate cancer cells, 81, 2006, ppS477-S477
Marignol L, Lawler M, Coffey M, Hollywood D., Achieving Hypoxia-Inducible Gene Expression in Tumors., Cancer Biological Therapy, 4, (4), 2005, p359-364.
Research Expertise
Description
Radiation biology seeks to understand why tumours respond differently to radiotherapy. This question has driven my research throughout my career and continues to shape the direction of my laboratory today. My research focuses on uncovering the hidden biological determinants of tumour radiation response and translating these discoveries into more precise approaches to cancer treatment. Over the past two decades, my work has investigated multiple dimensions of tumour biology, including hypoxia, radioresistance, DNA damage responses, molecular signalling pathways, mathematical modelling and predictive biomarkers. Together, these studies have sought to explain why biologically similar tumours often respond differently to the same treatment. As my research programme has evolved, I have become increasingly interested in biological variables that remain overlooked despite their potential to influence tumour behaviour. This has led to the development of the OSIRIS research programme, which investigates tumour sex chromosome state as a novel determinant of tumour heterogeneity and radiation response. By integrating laboratory biology, computational analysis and large-scale clinical datasets, our work aims to establish a more complete understanding of the biological factors that shape treatment outcomes. My laboratory combines experimental radiation biology with multidisciplinary collaborations spanning clinical oncology, medical physics, computational biology and artificial intelligence. While our discoveries originate within radiotherapy, they increasingly provide insights into fundamental tumour biology with implications for precision oncology and future cancer care. Alongside scientific discovery, I am committed to expanding the contribution of radiation biology through education, collaboration and research capacity building. I believe that the greatest advances in cancer research arise when biological understanding is integrated across disciplines and translated into meaningful improvements for patients.Projects
- Title
- Tumours have a sex: impact on the response of bladder cancer to therapy.
- Summary
- Years of experience with ionising radiation and/or chemical poisons has taught us that damaging the genome - cutting the DNA molecule that it consists of - can block the development of cancer and delay death. This project will investigate sex as a biological variable affecting the ability of bladder cancer to overcome these cuts and escape destruction. This work will compare the presence of the tools required to repair this damage in female and male bladder cancer patients, experimentally manipulate their availability and test their relationship with the cancer development process in laboratory models.
- Funding Agency
- PhD Provost Award 2021
- Date From
- October 2021
- Date To
- October 2025
- Title
- Creating the next-generation Cancer cell DNA damaging agent
- Summary
- Our insufficient, biologically challenged or poorly targeted ability to generate fatal DNA damage in cancer cells is recognised as an underlying major limiting factor to therapeutic efficacy of current cancer treatments. While efforts to modify the DNA damage response are yielding encouraging results, few novel anti-cancer DNA damaging agents are emerging. This project aims to create the next generation cancer cell DNA damaging agent.
- Date From
- October 2020
- Date To
- Present
- Title
- Tumours have a sex: Impact on disease development and treatment response.
- Summary
- The issue of sex bias or sex dismorphism in science is rapidly gaining momentum. Sex is a variable that affects several biological functions including both the innate and adaptive immune systems, the mode of stress-induced cell death and pain responses. Sex-specific studies have highlighted that drugs may affect males and females differently. But the impact of sex on the radiation response remains largely unstudied. Our lab investigates the impact of sex as a biological variable in the response to anti-cancer treatment. This work would involve the generation of in vitro survival curves using both female and male cancer cell lines, the review of published and recorded clinical data, and a solid evaluation of the potential sex-specific differences in the behaviour of cancer cells.
- Date From
- October 2019
- Date To
- Ongoing
- Title
- Development of a Companion diAgnostic teSt for radiotheraPy prostAte canceR patients (CASPAR)
- Summary
- There is an unmet need to develop companion diagnostic tests that can guide patients and their clinicians through the treatment decision process. This project propose assesses a novel protein for its prognostic and therapeutic potential in high risk radiotherapy prostate cancer patients. The long-term focus of CASPAR is to develop a novel companion diagnostic test and therapeutic combination that can allow personalized prescription of radiotherapy for these patients.
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/01/2017
- Date To
- 31/128/2017
- Title
- Prognosis potential of miRNAs in high risk radiotherapy prostate cancer patients
- Summary
- Failure to identify tumours with a radioresistant phenotype in the 1,000+ Irish prostate cancer patients/year receiving radiation therapy (RT) is associated with recurrence and decreased overall survival in approximatively 300-400 of these men, particularly those with localised Gleason 8-10 prostate carcinoma. This study aims to identify a miRNA panel that can be detected in diagnostic tissue biopsy specimen from high-risk patients, which will assist the identification of the 30-50% who are at greater risk of biochemical failure following RT.
- Funding Agency
- Irish Cancer Society
- Date From
- 01 December 2012
- Date To
- 01 December 2016
- Title
- Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?
- Summary
- Oxygen is essential for optimal cytotoxicity of radiation therapy. In the absence of oxygen at the time of radiation exposure, cell survival is commonly expected to increase by up to three-fold. We proposed that the proportion of cells completely deprived of oxygen within tumours may not be sufficiently large to be clinically significant and hypothesised that the surrounding hypoxic cells in fact may govern tumour response to radiotherapy. To test this hypothesis, this study proposed to re-examine the radioresponse of hypoxic prostate cancer cells and determine the consequences of these potentially clinically relevant oxygen levels.
Recognition
Representations
Specialist Examiner (Radiobiology), Royal College of Radiologists FRCR examinations, UK
Member, History Committee, Radiation Research Society (USA).
Prostate Cancer Research UK. Invited member, Research Advisory committee.
Editor, Clinical and Translational Radiation Oncology (Elsevier)
Invited member, The Advisory Committee for Radiation Oncology Practice (ACROP) committee.
Clinical and Translational Radiation Oncology, Editorial Board Member.
Environmental Protection Agency (EPA) Advisory Committee (Ireland) ( Minister Appointed Radiobiology advisor)
Cancers (Special Issue Invited Guest Editor)
European Society for Radiotherapy and Oncology, ESTRO 2021 Conference Scientific Advisory Group (Radiobiology Symposium development, Session chair, Abstract Reviewer)
Basic Radiobiology Teaching Course, European Society for Radiotherapy and Oncology (Faculty member)
University of Manchester, UK (PhD external Examiner)
Royal College of Surgeons in Ireland, Faculty of Radiologists, FRCR Radiobiology Examination Preparation course (Radiation Oncology Registrars) (Radiobiology Course development, Instructor (Radiobiology); Tutor (Statistics))
University College Dublin, School of Medicine. Professional Certificate in Radiation Safety. (Curriculum developer, Instructor).
Protocol for treatment interruption Compensation, Lung Radiation Therapy due to COVID-19 (Radiobiology Advisor)
European Society for Radiotherapy and Oncology, ESTRO 2020 Conference Scientific Advisory Group (Radiobiology Symposium development, Session chair, Abstract Reviewer)
Irish Radiation Research Society (Chair)
European Society for Radiotherapy and Oncology, Radiobiology Committee (Invited Member)
St Luke's Radiation Oncology Network - Radiobiology Steering Committee (Invited member)
Nature Scientific Reports (Editor)
Journal Reviewer - Molecular Biology Reports Urology Advances in Radiation Oncology Experimental and Therapeutic Medicine Physics and Imaging in Radiation Oncology technical innovations and patient support in radiation oncology International Journal of Molecular Medicine Cancers
The Wellcome - HRB Irish Clinical Academic Training Programme (Supervisor)
Grant Reviewer - Medical Research Council (UK), COST Action (European Commission), EIT Health COVID Rapid response (European Commission), ERA PerMed (European Commission)
Journal reviewer - Frontiers Oncology Clinical breast cancer Journal of Clinical Medicine Cells Molecular Oncology Oncology reports Oncology letters Oncotarget
GANIL (Grand Accélérateur d'Ions Lourds) - Application Reviewing Committee member
Queen's University Belfast, Northern Ireland (PhD external examiner)
Irish Radiation Research Society (Deputy Chair)
Irish Radiation Research Society (Secretary)
Grant Reviewer - Leading Fellows Postdoc Programme (The Netherlands)
University of Cape Town, South Africa (PhD external examiner)
Irish Radiation Research Society (Treasurer)
International Exchange, Global Health Disparities Research Training Program, Division of Public Health, Icahn School of Medicine at Mount Sinai, New York, USA. (Invited Mentor)
University of New South Wales, Australia (PhD external examiner)
Awards and Honours
Election to Fellowship, Trinity College Dublin
Faculty of Health Sciences, Dean's Research Award
Cancer Immunology Stimulus Award
GANIL (Grand Accélérateur d'Ions Lourds) Beam Access Award
Faculty of Health Sciences, Dean's Teaching Award
Science Foundation Ireland, TIDA
Early Career Investigator Award, Radiation Research Society (USA)
Irish Cancer Society, Prostate Cancer Project Grant
Travel Award, Radiation Research Society, USA
6th St Lukes Young Investigator Award
Early investigator award, Association for Radiation Research (UK)
Memberships
Irish Radiation Research Society
European Society for Radiotherapy and Oncology (ESTRO)
Radiation Research Society (USA)
Irish Association for Cancer Research