Professor Athanasios (Sakis) Mantalaris
Don Panoz Professor of Pharmaceutical Bi, Pharmacy
Publications and Further Research Outputs
Peer-Reviewed Publications
Mauricio Zamorano, C. Aguilar, Alessandra Lugo, Luis Felipe Herrera Jiménez, Jorge G. Farías, Athanasios Mantalaris, Engineering an Integrated Bioprocess to Produce Human Dental Pulp Stem Cell-Alginate-Based Bone Organoids, International Journal of Molecular Sciences, 26, (9), 2025, p4348 - 4348, p4348-4348
Nicki Panoskaltsis, Athanasios Mantalaris, The promise of human bone marrow organoids for drug discovery and testing in myeloid and lymphoid cancers, Expert Opinion on Drug Discovery, 2025, p1 - 4, p1-4
Gray M.A., de Janon A., Seeler M., Heller W.T., Panoskaltsis N., Mantalaris A., Champion J.A., Intracellular Biomacromolecule Delivery by Stimuli-Responsive Protein Vesicles Loaded by Hydrophobic Ion Pairing, ACS Omega, 10, (3), 2025, p2628 - 2639, p2628-2639
Murnane C., Gardiner N., Crehan O., Bacon C.L., McHugh R., Gilmer J.F., Mantalaris A., Panoskaltsis N., Chimeric Antigen Receptor-T (CAR-T) Cells as " Living Drugs ": A Clinical Pharmacist Perspective, Journal of Clinical Pharmacy and Therapeutics, 2024, 2024
Mingee, A. and Campano, A.L.Q. and Mantalaris, A., Monoclonal antibodies, 2024, 261-271pp
Mantalaris A, Panoskaltsis N, Killard F, Personalization in advanced cellular ImmunoTherapeutics: activities in Ireland., Cell & Gene Therapy Insights, 10, (11), 2024, p1645 - 1656
Klontzas M.E., Vernardis S.I., Batsali A., Papadogiannis F., Panoskaltsis N., Mantalaris A., Machine Learning and Metabolomics Predict Mesenchymal Stem Cell Osteogenic Differentiation in 2D and 3D Cultures, Journal of Functional Biomaterials, 15, (12), 2024
Fang, Z. and Ford, A.J. and Hu, T. and Zhang, N. and Mantalaris, A. and Coskun, A.F., Subcellular spatially resolved gene neighborhood networks in single cells, Cell Reports Methods, 3, (5), 2023
Alejandro de Janon, Aashis Thapa, Fang Zhou, Ahmet F. Coskun, Athanasios Mantalaris, Douglas K. Graham, Deborah DeRyckere, Nicki Panoskaltsis, Self-Supporting Human Acute Myeloid Leukemia (AML) Bone Marrow Organoids Established from Patient-Derived Xenografts Mimic the Human AML Microenvironment, with Distinct Cytokine Kinetics Correlating with Dynamic Cell Proliferation and Metabolic Shifts, Blood, 142, (Supplement 1), 2023, p1337 - 1337, p1337-1337
Alsobaie, S. and Alsobaie, T. and Alshammary, A.F. and Mantalaris, A. and Abudawood, M., Alginate Beads as a Promising Tool for Successful Production of Viable and Pluripotent Human-Induced Pluripotent Stem Cells in a 3D Culture System, Stem Cells and Cloning: Advances and Applications, 16, 2023, p61-73
de Janon A, Mantalaris A, Panoskaltsis N., Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesis., Journal of immunology (Baltimore, Md. : 1950), 210, (7), 2023, p895-904
Cha J.M., Hwang Y.-S., Kang D.-K., Lee J., Cooper E.S., Mantalaris A., Development of a Novel Perfusion Rotating Wall Vessel Bioreactor with Ultrasound Stimulation for Mass-Production of Mineralized Tissue Constructs, Tissue Engineering and Regenerative Medicine, 19, (4), 2022, p739 - 754, p739-754
Tomov, M.L. and Perez, L. and Ning, L. and Chen, H. and Jing, B. and Mingee, A. and Ibrahim, S. and Theus, A.S. and Kabboul, G. and Do, K. and Bhamidipati, S.R. and Fischbach, J. and McCoy, K. and Zambrano, B.A. and Zhang, J. and Avazmohammadi, R. and Mantalaris, A. and Lindsey, B.D. and Frakes, D. and Dasi, L.P. and Serpooshan, V. and Bauser-Heaton, H., Correction to: A 3D Bioprinted In Vitro Model of Pulmonary Artery Atresia to Evaluate Endothelial Cell Response to Microenvironment (Advanced Healthcare Materials, (2021), 10, 20, (2100968), 10.1002/adhm.202100968), Advanced Healthcare Materials, 11, (13), 2022
Allenby M.C., Okutsu N., Brailey K., Guasch J., Zhang Q., Panoskaltsis N., Mantalaris A., A Spatiotemporal Microenvironment Model to Improve Design of a Three-Dimensional Bioreactor for Red Cell Production, Tissue Engineering - Part A, 28, (1-2), 2022, p38 - 53, p38-53
Gyorgy R., Kostoglou M., Mantalaris A., Georgiadis M.C., Development of a multi-scale model to simulate mesenchymal stem cell osteogenic differentiation within hydrogels in a rotating wall bioreactor, Biochemical Engineering Journal, 186, 2022
Ning L., Shim J., Tomov M.L., Liu R., Mehta R., Mingee A., Hwang B., Jin L., Mantalaris A., Xu C., Mahmoudi M., Goldsmith K.C., Serpooshan V., A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor-Endothelial Cell Interactions Contributing to Solid Tumor Aggressive Behavior, Advanced Science, 9, (23), 2022
Alsobaie S., Alsobaie T., Mantalaris S., Rho-Associated Protein Kinase Inhibitor and Hypoxia Synergistically Enhance the Self-Renewal, Survival Rate, and Proliferation of Human Stem Cells, Stem Cells and Cloning: Advances and Applications, 15, 2022, p43 - 52, p43-52
Panoskaltsis N., McCarthy N.E., Stagg A.J., Mummery C.J., Husni M., Arebi N., Greenstein D., Price C.L., Al-Hassi H.O., Koutinas M., Mantalaris A., Knight S.C., Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm, Cancer Immunology, Immunotherapy, 70, (4), 2021, p1127 - 1142, p1127-1142
Buldum G., Mantalaris A., Systematic understanding of recent developments in bacterial cellulose biosynthesis at genetic, bioprocess and product levels, International Journal of Molecular Sciences, 22, (13), 2021
Cetnar A.D., Tomov M.L., Ning L., Jing B., Theus A.S., Kumar A., Wijntjes A.N., Bhamidipati S.R., Do K.P., Mantalaris A., Oshinski J.N., Avazmohammadi R., Lindsey B.D., Bauser-Heaton H.D., Serpooshan V., Patient-Specific 3D Bioprinted Models of Developing Human Heart, Advanced Healthcare Materials, 10, (15), 2021
Tomov M.L., Perez L., Ning L., Chen H., Jing B., Mingee A., Ibrahim S., Theus A.S., Kabboul G., Do K., Bhamidipati S.R., Fischbach J., McCoy K., Zambrano B.A., Zhang J., Avazmohammadi R., Mantalaris A., Lindsey B.D., Frakes D., Dasi L.P., Serpooshan V., Bauser-Heaton H., A 3D Bioprinted In Vitro Model of Pulmonary Artery Atresia to Evaluate Endothelial Cell Response to Microenvironment, Advanced Healthcare Materials, 10, (20), 2021
Paunovska K., da Silva Sanchez A., Foster M.T., Loughrey D., Blanchard E.L., Islam F.Z., Gan Z., Mantalaris A., Santangelo P.J., Dahlman J.E., Increased PIP3 activity blocks nanoparticle mRNA delivery, Science Advances, 6, (30), 2020
Papadogiannis F., Batsali A., Klontzas M.E., Karabela M., Georgopoulou A., Mantalaris A., Zafeiropoulos N.E., Chatzinikolaidou M., Pontikoglou C., Osteogenic differentiation of bone marrow mesenchymal stem cells on chitosan/gelatin scaffolds: Gene expression profile and mechanical analysis, Biomedical Materials (Bristol), 15, (6), 2020
Tsipa A., Pitt J.A., Banga J.R., Mantalaris A., A dual-parameter identification approach for data-based predictive modeling of hybrid gene regulatory network-growth kinetics in Pseudomonas putida mt-2, Bioprocess and Biosystems Engineering, 43, (9), 2020, p1671 - 1688, p1671-1688
Karakostas P., Panoskaltsis N., Mantalaris A., Georgiadis M.C., Optimization of CAR T-cell therapies supply chains, Computers and Chemical Engineering, 139, 2020
Doron G., Klontzas M.E., Mantalaris A., Guldberg R.E., Temenoff J.S., Multiomics characterization of mesenchymal stromal cells cultured in monolayer and as aggregates, Biotechnology and Bioengineering, 117, (6), 2020, p1761 - 1778, p1761-1778
Buldum G., Tsipa A., Mantalaris A., Linking Engineered Gene Circuit Kinetic Modeling to Cellulose Biosynthesis Prediction in Escherichia coli: Toward Bioprocessing of Microbial Cell Factories, Industrial and Engineering Chemistry Research, 59, (10), 2020, p4659 - 4669, p4659-4669
Novosel E., Borchers K., Kluger P.J., Mantalaris A., Matheis G., Pistolesi M., Schneider J., Wenz A., Lelkes P.I., New approaches to respiratory assist: Bioengineering an ambulatory, miniaturized bioartificial lung, ASAIO Journal, 65, (5), 2019, p422 - 429, p422-429
Kappatou C.D., Altunok O., Mhamdi A., Mantalaris A., Mitsos A., Sequential and Simultaneous Optimization Strategies for Increased Production of Monoclonal Antibodies, Computer Aided Chemical Engineering, 46, 2019, p1021 - 1026, p1021-1026
Mortera-Blanco T., Rende M., Panoskaltsis N., Mantalaris A., Tissue engineering of normal and abnormal bone marrow, Comprehensive Biotechnology, 2019, p225 - 235, p225-235
Allenby M.C., Panoskaltsis N., Tahlawi A., Dos Santos S.B., Mantalaris A., Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry, Biomaterials, 188, 2019, p24 - 37, p24-37
Klontzas M.E., Reakasame S., Silva R., Morais J.C.F., Vernardis S., MacFarlane R.J., Heliotis M., Tsiridis E., Panoskaltsis N., Boccaccini A.R., Mantalaris A., Oxidized alginate hydrogels with the GHK peptide enhance cord blood mesenchymal stem cell osteogenesis: A paradigm for metabolomics-based evaluation of biomaterial design, Acta Biomaterialia, 88, 2019, p224 - 240, p224-240
Grilo A.L., Mantalaris A., Apoptosis: A mammalian cell bioprocessing perspective, Biotechnology Advances, 37, (3), 2019, p459 - 475, p459-475
Grilo A.L., Mantalaris A., The Increasingly Human and Profitable Monoclonal Antibody Market, Trends in Biotechnology, 37, (1), 2019, p9 - 16, p9-16
Grilo A.L., Mantalaris A., A Predictive Mathematical Model of Cell Cycle, Metabolism, and Apoptosis of Monoclonal Antibody-Producing GS"NS0 Cells, Biotechnology Journal, 14, (11), 2019
Devito, Liani and Klontzas, Michail E. and Cvoro, Aleksandra and Galleu, Antonio and Simon, Marisa and Hobbs, Carl and Dazzi, Francesco and Mantalaris, Athanasios and Khalaf, Yacoub and Ilic, Dusko, Comparison of human isogeneic Whartonâ s jelly MSCs and iPSC-derived MSCs reveals differentiation-dependent metabolic responses to IFNG stimulation, Cell Death and Disease, 10, (4), 2019
Gyorgy R., Klontzas M.E., Kostoglou M., Panoskaltsis N., Mantalaris A., Georgiadis M.C., Capturing mesenchymal stem cell heterogeneity during osteogenic differentiation: an experimental-modeling approach, Industrial and Engineering Chemistry Research, 58, (31), 2019, p13900 - 13909, p13900-13909
Tahlawi A., Klontzas M.E., Allenby M.C., Morais J.C.F., Panoskaltsis N., Mantalaris A., RGD-functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation, Journal of Tissue Engineering and Regenerative Medicine, 13, (2), 2019, p232 - 243, p232-243
Kappatou C.D., Mhamdi A., Campano A.Q., Mantalaris A., Mitsos A., Model-Based Dynamic Optimization of Monoclonal Antibodies Production in Semibatch Operation - Use of Reformulation Techniques, Industrial and Engineering Chemistry Research, 57, (30), 2018, p9915 - 9924, p9915-9924
Buldum G., Bismarck A., Mantalaris A., Recombinant biosynthesis of bacterial cellulose in genetically modified Escherichia coli, Bioprocess and Biosystems Engineering, 41, (2), 2018, p265 - 279, p265-279
Allenby M.C., Tahlawi A., Morais J.C.F., Li K., Panoskaltsis N., Mantalaris A., Ceramic hollow fibre constructs for continuous perfusion and cell harvest from 3D hematopoietic organoids, Stem Cells International, 2018, 2018
Tsipa A., Koutinas M., Usaku C., Mantalaris A., Optimal bioprocess design through a gene regulatory network " Growth kinetic hybrid model: Towards replacing Monod kinetics, Metabolic Engineering, 48, 2018, p129 - 137, p129-137
Misener R., Allenby M.C., Fuentes-Gari M., Gupta K., Wiggins T., Panoskaltsis N., Pistikopoulos E.N., Mantalaris A., Stem cell biomanufacturing under uncertainty: A case study in optimizing red blood cell production, AIChE Journal, 64, (8), 2018, p3011 - 3022, p3011-3022
Quiroga-Campano A.L., Panoskaltsis N., Mantalaris A., Energy-based culture medium design for biomanufacturing optimization: A case study in monoclonal antibody production by GS-NS0 cells, Metabolic Engineering, 47, 2018, p21 - 30, p21-30
Totti S., Allenby M.C., Dos Santos S.B., Mantalaris A., Velliou E.G., A 3D bioinspired highly porous polymeric scaffolding system for: In vitro simulation of pancreatic ductal adenocarcinoma, RSC Advances, 8, (37), 2018, p20928 - 20940, p20928-20940
Krieger, Alexandra and NaÅ cu, Ioana and Panoskaltsis, Nicki and Mantalaris, Athanasios and Georgiadis, Michael C. and Pistikopoulos, Efstratios N., Volatile Anaesthesia, 2017, 67 â" 102pp
Cha, Jae Min and Mantalaris, Athanasios and Jung, Sunyoung and Ji, Yurim and Bang, Oh Young and Bae, Hojae, Mesoderm Lineage 3D Tissue Constructs Are Produced at Large-Scale in a 3D Stem Cell Bioprocess, Biotechnology Journal, 12, (9), 2017
Gyorgy R., Klontzas M.E., Kostoglou M., Panoskaltsis N., Georgiadis M.C., Mantalaris A., An Integrated Experimental-Modelling Approach of Mesenchymal Stem Cell Bioprocess towards Osteogenic Differentiation, IFAC-PapersOnLine, 50, (1), 2017, p9877 - 9882, p9877-9882
Papathanasiou, Maria M. and Quiroga-Campano, Ana L. and Steinebach, Fabian and Elviro, Montaña and Mantalaris, Athanasios and Pistikopoulos, Efstratios N., Advanced model-based control strategies for the intensification of upstream and downstream processing in mAb production, Biotechnology Progress, 33, (4), 2017, p966 â" 988
Zavitsanou, Stamatina and Mantalaris, Athanasios and Georgiadis, Michael C. and Pistikopoulos, Efstratios N., Part A: Type 1 Diabetes Mellitus: Modelling, Model Analysis and Optimization, 2017, 159 â" 224pp
Kang, Yunyi and Georgiou, Anastasia I. and MacFarlane, Robert J. and Klontzas, Michail E. and Heliotis, Manolis and Tsiridis, Eleftherios and Mantalaris, Athanasios, Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells, Journal of Tissue Engineering and Regenerative Medicine, 11, (7), 2017, p1929 â" 1940
Papathanasiou, Maria M. and Steinebach, Fabian and Morbidelli, Massimo and Mantalaris, Athanasios and Pistikopoulos, Efstratios N., Intelligent, model-based control towards the intensification of downstream processes, Computers and Chemical Engineering, 105, 2017, p173 â" 184
Velliou, Eirini G. and Pefani, Eleni and dos Santos, Susana Brito and Fuentes-Gari, Maria and Misener, Ruth and Panoskaltsis, Nicki and Mantalaris, Athanasios and Georgiadis, Michael C. and Pistikopoulos, Efstratios N., In vitro Studies: Acute Myeloid Leukaemia, 2017, 233 â" 264pp
Gyorgy R., Klontzas M.E., Kostoglou M., Panoskaltsis N., Mantalaris A., Georgiadis M.C., A Population Balance Model for Stem Cell Differentiation Bioprocesses, Computer Aided Chemical Engineering, 40, 2017, p2761 - 2766, p2761-2766
Kappatou, Chrysoula D. and Mhamdi, Adel and Campano, Ana Quiroga and Mantalaris, Athanasios and Mitsos, Alexander, Dynamic Optimization of the Production of Monoclonal Antibodies in Semi-batch Operation, Computer Aided Chemical Engineering, 40, 2017, p2161 â" 2166
Reissis, Dimitris and Tang, Quen Oak and Cooper, Nina Catherine and Carasco, Clare Francesca and Gamie, Zakareya and Mantalaris, Athanasios and Tsiridis, Eleftherios, Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair, Expert Opinion on Biological Therapy, 16, (4), 2016, p535 â" 557
Tsipa, Argyro and Koutinas, Michalis and Pistikopoulos, Efstratios N. and Mantalaris, Athanasios, Transcriptional kinetics of the cross-talk between the ortho-cleavage and TOL pathways of toluene biodegradation in Pseudomonas putida mt-2, Journal of Biotechnology, 228, 2016, p112 â" 123
Campano, Ana Quiroga and Papathanasiou, Maria M. and Pistikopoulos, Efstratios N. and Mantalaris, Athanasios, A Predictive Model for Energy Metabolism and ATP Balance in Mammalian Cells: Towards the Energy-Based Optimization of mAb Production, Computer Aided Chemical Engineering, 38, 2016, p1581 â" 1586
Klontzas, Michail E. and Kenanidis, Eustathios I. and MacFarlane, Robert J. and Michail, Theodoros and Potoupnis, Michael E. and Heliotis, Manolis and Mantalaris, Athanasios and Tsiridis, Eleftherios, Investigational drugs for fracture healing: Preclinical & clinical data, Expert Opinion on Investigational Drugs, 25, (5), 2016, p585 â" 596
Papathanasiou, Maria M. and Mantalaris, Athanasios and Pistikopoulos, Efstratios N., Advanced control strategies for a periodic, two-column chromatographic process, 2016
Kiparissides, A. and Pistikopoulos, E.N. and Mantalaris, A., On the model-based optimization of secreting mammalian cell (GS-NS0) cultures, Biotechnology and Bioengineering, 112, (3), 2015, p536 â" 548
Fuentes-Ga", M., Misener, R., Georgiadis, M.C., Kostoglou, M., Panoskaltsis, N., Pistikopoulos, E.N., Mantalaris, A., Chemotherapy optimization in Leukemia: Selecting the right mathematical models for the right biological processes, IFAC-PapersOnLine, 28, (20), 2015, p534-539
Papathanasiou, Maria M. and Campano, Ana Quiroga and Steinebach, Fabian and Mueller-Spaeth, Thomas and Morbidelli, Massimo and Mantalaris, Athanasios and Pistikopoulos, Efstratios N., 424226 Advanced control strategies towards the intensification of monoclonal antibody production, 2015, pp429 â" 431
Savvopoulos, S., Misener, R., Panoskaltsis, N., Pistikopoulos, E.N., Mantalaris, A., Global Sensitivity Analysis for a Model of B-Cell Chronic Lymphocytic Leukemia Disease Trajectories, Computer Aided Chemical Engineering, 37, 2015, p185-190
Fuentes-Garí, M., Velliou, E., Misener, R., Pefani, E., Rende, M., Panoskaltsis, N., Mantalaris, A., Pistikopoulos, E.N., A systematic framework for the design, simulation and optimization of personalized healthcare: Making and healing blood, Computers and Chemical Engineering, 81, 2015, p80-93
Papathanasiou, Maria M. and Campano, Ana Quiroga and Steinebach, Fabian and Mueller-Spaeth, Thomas and Morbidelli, Massimo and Mantalaris, Athanasios and Pistikopoulos, Efstratios N., Advanced control strategies towards the intensification of monoclonal antibody production, 2, 2015, pp714 â" 716
Fauzi, I., Panoskaltsis, N., Mantalaris, A., In vitro differentiation of embryonic stem cells into hematopoietic lineage: Towards erythroid progenitor"s production, Methods in Molecular Biology, 1341, 2015, p217-234
Papantoniou, Ioannis and Mantalaris, Athanasios and Sonnaert, Maarten and Lambrechts, Toon and Aerts, Jean-Marie and Geris, Liesbet and Schrooten, Jan, Product and Process Design: Toward Industrial TE Manufacturing, 2014, 747 â" 781pp
Gamie, Zakareya and MacFarlane, Robert J. and Tomkinson, Alicia and Moniakis, Alexandros and Tran, Gui Tong and Gamie, Yehya and Mantalaris, Athanasios and Tsiridis, Eleftherios, Skeletal tissue engineering using mesenchymal or embryonic stem cells: Clinical and experimental data, Expert Opinion on Biological Therapy, 14, (11), 2014, p1611 â" 1639
Mortera-Blanco T., Mantalaris A., Bismarck A., Aqel N., Panoskaltsis N., Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds, Biomaterials, 32, (35), 2011, p9263 - 9270, p9263-9270
Non-Peer-Reviewed Publications
Nicki Panoskaltsis, Athanasios Mantalaris, Ana Luz Quiroga Campano, 'Methods and systems for personalized in-silico hematopoiesis and disease/leukemia simulation for treatment selection and optimization', WO, US, 2024, 18 March 2025, Emory University Georgia Tech Research Corp
Nicki Panoskaltsis, Athanasios Mantalaris, Ana Luz Quiroga CAMPANO, 'Methods and systems for personalized in-silico hematopoiesis and disease/leukemia simulation for treatment selection and optimization', US PTO, US20240428951A1, 2024, 18 March 2025, Emory University; Georgia Tech Research Corp